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Research

Publications: Prof Sussan Nourshargh

Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J et al. ( 2022 ) . Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A . Nat Commun vol. 13 , ( 1 )
Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S ( 2021 ) . Endothelial cell autophagy keeps neutrophil trafficking under control . Autophagy vol. 17 , ( 12 ) 4509 - 4511 .
Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR et al. ( 2021 ) . Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome . Circulation vol. 144 , ( 22 ) 1777 - 1794 .
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al. ( 2021 ) . Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation . Immunity vol. 54 , ( 9 ) 1989 - 2004.e9 .
Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, Ortega-Nogales FJ, Balabasquer M, Gonzalo P, Khiar-Fernández N, Rolas L et al. ( 2021 ) . Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson-Gilford Progeria Syndrome . ACS Central Science vol. 7 , ( 8 ) 1300 - 1310 .
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al. ( 2021 ) . Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage . Immunity vol. 54 , ( 7 ) 1494 - 1510.e7 .
Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD et al. ( 2021 ) . Circulating bmp9 protects the pulmonary endothelium during inflammation-induced lung injury in mice . American Journal of Respiratory and Critical Care Medicine vol. 203 , ( 11 ) 1419 - 1430 .
Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M et al. ( 2020 ) . Local microvascular leakage promotes trafficking of activated neutrophils to remote organs . Journal of Clinical Investigation
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W, Voisin M-B ( 2019 ) . Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo . Frontiers in Immunology
Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N et al. ( 2019 ) . Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) . European Journal of Immunology vol. 49 , ( 10 ) 1457 - 1973 .
Voisin MB, Nourshargh S ( 2019 ) . Neutrophil trafficking to lymphoid tissues: physiological and pathological implications . Journal of Pathology vol. 247 , ( 5 ) 662 - 671 .
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C et al. ( 2019 ) . Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury . Journal of Pathology vol. 248 , ( 1 ) 88 - 102 .
Reglero-Real N, Rolas L, Nourshargh S ( 2019 ) . Leukocyte Trafficking: Time to Take Time Seriously . Immunity vol. 50 , ( 2 ) 273 - 275 .
NOURSHARGH S, ROLAS L, BARKAWAY A ( 2019 ) . Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome . Nature Medicine423 - 426 .
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al. ( 2019 ) . Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration . PLoS Biology vol. 17 , ( 12 )
GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E et al. ( 2018 ) . Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis . Immunity
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2018 ) . Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Med vol. 15 , ( 10 ) e1002694 - e1002694 .
Cossarizza A, Chang H-D, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V et al. ( 2018 ) . Guidelines for the use of flow cytometry and cell sorting in immunological studies . Eur J Immunol vol. 47 , ( 10 ) 1584 - 1797 .
Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M et al. ( 2018 ) . Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis . J Am Heart Assoc vol. 7 , ( 4 )
Schulz-Fincke A-C, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S et al. ( 2018 ) . Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers . Biochemistry vol. 57 , ( 5 ) 742 - 752 .
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN, Henson SM ( 2017 ) . Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK . Aging Cell
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al. ( 2017 ) . Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma . PLoS Medicine
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al. ( 2017 ) . Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study . PLoS Medicine vol. 14 , ( 7 )
Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D ( 2017 ) . Galectin-3: A positive regulator of leukocyte recruitment in the inflamed microcirculation . Journal of Immunology vol. 198 , ( 11 ) 4458 - 4469 .
VOISIN M ( 2017 ) . Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation . Scientific Reports
Barzilai S, Yadav SK, Morrell S, Roncato F, Klein E, Stoler-Barak L, Golani O, Feigelson SW et al. ( 2017 ) . Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments . Cell Reports vol. 18 , ( 3 ) 685 - 699 .
Herrera C, Voisin M-B, Escalante T, Rucavado A, Nourshargh S, Gutiérrez JM ( 2016 ) . Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle . PLoS One vol. 11 , ( 12 ) Article 0168643 , e0168643 - e0168643 .
Reglero-Real N, Colom B, Bodkin JV, Nourshargh S ( 2016 ) . Endothelial Cell Junctional Adhesion Molecules . Arteriosclerosis, Thrombosis and Vascular BiologyATVBAHA.116.307610 - ATVBAHA.116.307610 .
WHITEFORD J, Ma B, Woodfin, Nourshargh ( 2016 ) . Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment . Journal of Pathology
Nourshargh S, Renshaw SA, Imhof BA ( 2016 ) . Reverse Migration of Neutrophils: Where, When, How, and Why? . Trends in immunology
Woodfin A, Beyrau M, Voisin MB, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S ( 2016 ) . ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia . Blood vol. 127 , ( 7 ) 898 - 907 .
Madalli S, Beyrau M, Whiteford J, Duchene J, Nandhra IS, Patel NSA, Motwani MP, Gilroy DW et al. ( 2015 ) . Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states . Biology of Sex Differences vol. 6 , ( 1 )
Yeh JSM, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO et al. ( 2015 ) . Quantitative Ultrasound Molecular Imaging . Ultrasound in Medicine and Biology vol. 41 , ( 9 ) 2478 - 2496 .
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD ( 2015 ) . Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction . Blood vol. 126 , ( 10 ) e11 - e18 .
Yeh JSM, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO et al. ( 2015 ) . A targeting microbubble for ultrasound molecular imaging . PLoS ONE vol. 10 , ( 7 )
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al. ( 2015 ) . Leukotriene B<inf>4</inf>-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo . Immunity vol. 42 , ( 6 ) 1075 - 1086 .
Herrera C, Escalante T, Voisin MB, Rucavado A, Morazán D, Macêdo JKA, Calvete JJ, Sanz L et al. ( 2015 ) . Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage . PLoS Neglected Tropical Diseases vol. 9 , ( 4 )
Nourshargh S, Alon R ( 2014 ) . Leukocyte Migration into Inflamed Tissues . Immunity vol. 41 , ( 5 ) 694 - 707 .
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR ( 2014 ) . Shed syndecan-2 inhibits angiogenesis . J Cell Sci vol. 127 , ( Pt 21 ) 4788 - 4799 .
Finsterbusch M, Voisin M-B, Beyrau M, Williams TJ, Nourshargh S ( 2014 ) . Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF . J Exp Med vol. 211 , ( 7 ) 1307 - 1314 .
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al. ( 2014 ) . Leukotriene B<inf>4</inf>-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo . Immunity
Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A ( 2014 ) . ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo . J Cell Sci vol. 127 , ( Pt 3 ) 620 - 629 .
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T et al. ( 2013 ) . Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer . FASEB J vol. 27 , ( 10 ) 4244 - 4253 .
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S et al. ( 2013 ) . A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation . Blood vol. 122 , ( 4 ) 608 - 617 .
Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y et al. ( 2013 ) . Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis . Proc Natl Acad Sci U S A vol. 110 , ( 21 ) 8656 - 8661 .
Nourshargh S ( 2013 ) . L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation . Presse Med vol. 42 , ( 4 Pt 2 ) 498 - 499 .
Alon R, Nourshargh S ( 2013 ) . Learning in motion: pericytes instruct migrating innate leukocytes . Nat Immunol vol. 14 , ( 1 ) 14 - 15 .
Voisin M-B, Nourshargh S ( 2013 ) . Neutrophil transmigration: emergence of an adhesive cascade within venular walls . J Innate Immun vol. 5 , ( 4 ) 336 - 347 .
Beyrau M, Bodkin JV, Nourshargh S ( 2012 ) . Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity . Open Biol vol. 2 , ( 11 )
Kishore M, Ma L, Cornish G, Nourshargh S, MarelliBerg F ( 2012 ) . Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31 . Transplantation . vol. 94 ,
Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM ( 2012 ) . CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo . J Immunol vol. 189 , ( 8 ) 4104 - 4111 .
Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S, Priestley JV ( 2012 ) . The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats . Brain Behav vol. 2 , ( 4 ) 402 - 414 .
Proebstl D, Voisin M-B, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S ( 2012 ) . Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo . J Exp Med vol. 209 , ( 6 ) 1219 - 1234 .
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al. ( 2012 ) . The peritoneal tumour microenvironment of high-grade serous ovarian cancer . J Pathol vol. 227 , ( 2 ) 136 - 145 .
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD et al. ( 2012 ) . Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves . FASEB J vol. 26 , ( 3 ) 1064 - 1076 .
Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg FM ( 2012 ) . Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31 . PLoS One vol. 7 , ( 6 )
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR ( 2011 ) . Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148 . Mol Biol Cell vol. 22 , ( 19 ) 3609 - 3624 .
Woodfin A, Voisin M-B, Beyrau M, Colom B, Caille D, Diapouli F-M, Nash GB, Chavakis T et al. ( 2011 ) . The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo . Nat Immunol vol. 12 , ( 8 ) 761 - 769 .
Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H et al. ( 2011 ) . CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism . J Leukoc Biol vol. 89 , ( 3 ) 413 - 421 .
Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K et al. ( 2010 ) . Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance . Proc Natl Acad Sci U S A vol. 107 , ( 45 ) 19461 - 19466 .
Nourshargh S, Hordijk PL, Sixt M ( 2010 ) . Breaching multiple barriers: leukocyte motility through venular walls and the interstitium . Nat Rev Mol Cell Biol vol. 11 , ( 5 ) 366 - 378 .
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S, Perretti M ( 2010 ) . The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature . Br J Pharmacol vol. 160 , ( 1 ) 171 - 180 .
Woodfin A, Voisin M-B, Nourshargh S ( 2010 ) . Recent developments and complexities in neutrophil transmigration . Curr Opin Hematol vol. 17 , ( 1 ) 9 - 17 .
Voisin M-B, Pröbstl D, Nourshargh S ( 2010 ) . Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation . Am J Pathol vol. 176 , ( 1 ) 482 - 495 .
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al. ( 2009 ) . Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury . Arterioscler Thromb Vasc Biol vol. 29 , ( 10 ) 1509 - 1515 .
Voisin M-B, Woodfin A, Nourshargh S ( 2009 ) . Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo . Arterioscler Thromb Vasc Biol vol. 29 , ( 8 ) 1193 - 1199 .
Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B, Nourshargh S ( 2009 ) . Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1 . BLOOD vol. 113 , ( 24 ) 6246 - 6257 .
Woodfin A, Voisin M-B, Imhof BA, Dejana E, Engelhardt B, Nourshargh S ( 2009 ) . Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1 . Blood vol. 113 , ( 24 ) 6246 - 6257 .
Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT et al. ( 2009 ) . Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis . Am J Pathol vol. 174 , ( 4 ) 1212 - 1220 .
Woodfin A, Voisin M-B, Nourshargh S ( 2007 ) . PECAM-1: a multi-functional molecule in inflammation and vascular biology . Arterioscler Thromb Vasc Biol vol. 27 , ( 12 ) 2514 - 2523 .
Scheiermann C, Meda P, Aurrand-Lions M, Madani R, Yiangou Y, Coffey P, Salt TE, Ducrest-Gay D et al. ( 2007 ) . Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves . Science vol. 318 , ( 5855 ) 1472 - 1475 .
Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA ( 2007 ) . JAM family and related proteins in leukocyte migration (Vestweber series) . Arterioscler Thromb Vasc Biol vol. 27 , ( 10 ) 2104 - 2112 .
Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M et al. ( 2007 ) . JAM-C regulates unidirectional monocyte transendothelial migration in inflammation . Blood vol. 110 , ( 7 ) 2545 - 2555 .
Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin M-B, Scheiermann C, Haskard DO, Dejana E et al. ( 2007 ) . JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration . Blood vol. 110 , ( 6 ) 1848 - 1856 .
Ley K, Laudanna C, Cybulsky MI, Nourshargh S ( 2007 ) . Getting to the site of inflammation: the leukocyte adhesion cascade updated . Nat Rev Immunol vol. 7 , ( 9 ) 678 - 689 .
NOURSHARGH S, Krombach F, Dejana E, Khandoga A, Woodfin A, Reichal AC, Haskard DO, Scheiermann C et al. ( 2007 ) . JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration . Blood vol. 110 , ( 6 ) 1848 - 1856 .
Young RE, Voisin M-B, Wang S, Dangerfield J, Nourshargh S ( 2007 ) . Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice . Br J Pharmacol vol. 151 , ( 5 ) 628 - 637 .
Voisin MB, Woodfin A, Nourshargh S ( 2007 ) . Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo . FASEB JOURNAL . vol. 21 , A127 - A127 .
Woodfin A, Larbi K, Krombach F, Dejana E, Nourshargh S ( 2007 ) . PECAM-1 & JAM-A mediate leukocyte transmigration in a stimulus-specific manner: Is this phenomenon governed by the strain of mice investigated? . FASEB JOURNAL . vol. 21 , A127 - A127 .
Potter PK, Larbi KY, Nourshargh S, Botto M ( 2007 ) . Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1 . Mol Immunol vol. 44 , ( 6 ) 1135 - 1140 .
Voisin M-B, Nourshargh S ( 2007 ) . Role of α6β1 integrin in leukocyte adhesion and transmigration . Adhesion Molecules: Function and Inhibition ,
Nourshargh S, Krombach F, Dejana E ( 2006 ) . The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues . J Leukoc Biol vol. 80 , ( 4 ) 714 - 718 .
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L et al. ( 2006 ) . Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils . Journal of Cell Biology vol. 173 , ( 6 ) i11 - i11 .
Huang M-T, Larbi KY, Scheiermann C, Woodfin A, Gerwin N, Haskard DO, Nourshargh S ( 2006 ) . ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration . Blood vol. 107 , ( 12 ) 4721 - 4727 .
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L et al. ( 2006 ) . Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils . J Exp Med vol. 203 , ( 6 ) 1519 - 1532 .
Marelli-Berg FM, Nourshargh S ( 2006 ) . Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules . Leukocyte Trafficking: Molecular Mechanisms, Therapeutic Targets, and Methods ,
Woodfin A, Reichel C, Khandoga A, Corada M, Haskard D, Dejana E, Krombach F, Nourshargh S ( 2006 ) . JAM-A mediates leukocyte transmigration in a stimulus-specific manner . FASEB JOURNAL . vol. 20 , A862 - A862 .
Voisin MB, Woodfin A, Dawes T, Nourshargh S ( 2006 ) . Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury . FASEB JOURNAL . vol. 20 , A1083 - A1083 .
Voisin MB, Wang SJ, Larbi K, Scheiermann C, Sorokin L, Nourshargh S ( 2006 ) . Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions . FASEB JOURNAL . vol. 20 , A1322 - A1322 .
Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu S-Y, Munisamy S et al. ( 2006 ) . Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo . J Leukoc Biol vol. 79 , ( 3 ) 539 - 554 .
Reichel CA, Khandoga A, Woodfin A, Corada M, Dejana E, Nourshargh S, Krombach F ( 2006 ) . JAM-A mediates leukocyte transmigration dynamically and in a stimulus-specific manner . JOURNAL OF VASCULAR RESEARCH . vol. 43 , 576 - 576 .
Little MA, Bhangal G, Smyth CL, Nakada MT, Cook HT, Nourshargh S, Pusey CD ( 2006 ) . Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis . J Am Soc Nephrol . vol. 17 , 160 - 169 .
Ambrose LR, Little MA, Nourshargh S, Pusey CD ( 2005 ) . Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy . Kidney Int vol. 68 , ( 6 ) 2912 - 2913 .
Little MA, Pusey CD, Nourshargh S ( 2005 ) . Intravital microscopy in the study of ANCA-associated systemic vasculitis . Clin Nephrol . vol. 64 , 465 - 470 .
Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, Pusey CD ( 2005 ) . Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo . Blood vol. 106 , ( 6 ) 2050 - 2058 .
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ, Perretti M ( 2005 ) . Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro . J Leukoc Biol vol. 78 , ( 3 ) 639 - 646 .
Aurrand-Lions M, Lamagna C, Dangerfield JP, Wang S, Herrera P, Nourshargh S, Imhof BA ( 2005 ) . Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation . J Immunol vol. 174 , ( 10 ) 6406 - 6415 .
Wang S, Dangerfield JP, Young RE, Nourshargh S ( 2005 ) . PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration . J Cell Sci vol. 118 , ( Pt 9 ) 2067 - 2076 .
Huang MT, Larbi KY, Gerwin N, Nourshargh S ( 2005 ) . ICAM-2 mediates PECAM-1-independent neutrophil transmigration in vivo . FASEB JOURNAL . vol. 19 , A1504 - A1505 .
Voisin MB, Young R, Dangerfield J, Wijayasiri L, Wang SJ, Nourshargh S ( 2005 ) . LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo . FASEB JOURNAL . vol. 19 , A1717 - A1717 .
Wang SJ, Dangerfield J, Voisin MB, Tran M, Maxwell P, Sorokin L, Nourshargh S ( 2005 ) . Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane . FASEB JOURNAL . vol. 19 , A1504 - A1504 .
Nourshargh S, Marelli-Berg FM ( 2005 ) . Transmigration through venular walls: a key regulator of leukocyte phenotype and function . Trends Immunol vol. 26 , ( 3 ) 157 - 165 .
Dangerfield JP, Wang S, Nourshargh S ( 2005 ) . Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo . J Leukoc Biol vol. 77 , ( 2 ) 159 - 165 .
Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S et al. ( 2004 ) . Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo . Blood vol. 103 , ( 8 ) 3111 - 3116 .
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S ( 2004 ) . Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo . J Immunol vol. 172 , ( 7 ) 4493 - 4502 .
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ et al. ( 2004 ) . Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis . J Immunol vol. 172 , ( 6 ) 3406 - 3414 .
McMillan SJ, Kearley J, Campbell JD, Zhu X-W, Larbi KY, Shipley JM, Senior RM, Nourshargh S et al. ( 2004 ) . Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation . J Immunol vol. 172 , ( 4 ) 2586 - 2594 .
Yadav R, Larbi KY, Young RE, Nourshargh S ( 2003 ) . Migration of leukocytes through the vessel wall and beyond . THROMBOSIS AND HAEMOSTASIS vol. 90 , ( 4 ) 598 - 606 .
James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D et al. ( 2003 ) . Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism . Blood vol. 102 , ( 6 ) 2173 - 2179 .
Marshall D, Dangerfield JP, Bhatia VK, Larbi KY, Nourshargh S, Haskard DO ( 2003 ) . MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha . Rheumatology (Oxford) vol. 42 , ( 8 ) 929 - 934 .
Larbi KY, Dangerfield JP, Nourshargh S ( 2003 ) . MMP-9 regulates eosinophil transmigration and expression of CCR3 on transmigrated eosinophils in vivo . FASEB JOURNAL . vol. 17 , A1071 - A1071 .
Young RE, Thompson RD, Larbi KY, La M, Roberts C, Shapir SD, Perretti M, Nourshargh S ( 2003 ) . Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration . FASEB JOURNAL . vol. 17 , A1188 - A1188 .
Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S ( 2003 ) . P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses . J Leukoc Biol vol. 73 , ( 1 ) 65 - 73 .
Young RE, Thompson RD, Nourshargh S ( 2002 ) . Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules . Br J Pharmacol vol. 137 , ( 8 ) 1237 - 1246 .
Dangerfield J, Larbi KY, Huang M-T, Dewar A, Nourshargh S ( 2002 ) . PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane . J Exp Med vol. 196 , ( 9 ) 1201 - 1211 .
Marshall D, Dangerfield JD, Bhatia VK, Larbi KY, Nourshargh S, Haskard DO ( 2002 ) . MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha . RHEUMATOLOGY vol. 41 , 32 - 32 .
Young RE, Thompson RD, Nourshargh S ( 2002 ) . Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules . BRIT J PHARMACOL vol. 135 ,
Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW, Nourshargh S ( 2001 ) . Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane . Blood vol. 97 , ( 6 ) 1854 - 1860 .
Marshall D, Bhatia VK, Ahmed S, Lidington EA, Larbi KY, Nourshargh S, Haskard DO ( 2001 ) . Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis . FASEB J vol. 15 , ( 4 ) A328 - A328 .
Larbi KY, Allen AR, Tam FWK, Haskard DO, Lobb RR, Silva PMR, Nourshargh S ( 2000 ) . VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: Evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration . Blood vol. 96 , ( 10 ) 3601 - 3609 .
Thompson RD, Wakelin MW, Larbi KY, Dewar A, Asimakopoulos G, Horton MA, Nakada MT, Nourshargh S ( 2000 ) . Divergent effects of platelet-endothelial cell adhesion molecule-1 and β<inf>3</inf> integrin blockade on leukocyte transmigration in vivo . Journal of Immunology vol. 165 , ( 1 ) 426 - 434 .
Asimakopoulos G, Thompson R, Nourshargh S, Lidington EA, Mason JC, Ratnatunga CP, Haskard DO, Taylor KM et al. ( 2000 ) . An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation . Journal of Thoracic and Cardiovascular Surgery vol. 120 , ( 2 ) 361 - 369 .
Davies D, Larbi K, Allen A, Sanz MJ, Weg VB, Haskard DO, Lobb RR, Nourshargh S ( 1999 ) . VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB<inf>4</inf>: Evidence for basal expression of functional VCAM-1 in rat skin . Immunology vol. 97 , ( 1 ) 150 - 158 .
Nagai K, Larkin S, Hartnell A, Larbi K, Razi Aghakhani M, Windley C, Davies D, Lobb RR et al. ( 1999 ) . Human eotaxin induces eosinophil extravasation through rat mesenteric venules: Role of α<inf>4</inf> integrins and vascular cell adhesion molecule-1 . Immunology vol. 96 , ( 2 ) 176 - 183 .
Sanz MJ, Marinova-Mutafchieva L, Green P, Lobb RR, Feldmann M, Nourshargh S ( 1998 ) . IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-α and α<inf>4</inf> integrin/VCAM-1 adhesion pathways . Journal of Immunology vol. 160 , ( 11 ) 5637 - 5645 .
Sanz MJ, Ponath PD, Mackay CR, Newman W, Miyasaka M, Tamatani T, Flanagan BF, Lobb RR et al. ( 1998 ) . Human eotaxin-induces α<inf>4</inf> and β<inf>2</inf> integrin-dependent eosinophil accumulation in rat skin in vivo: Delayed generation of eotaxin in response to IL-4 . Journal of Immunology vol. 160 , ( 7 ) 3569 - 3576 .
Wakelin MW, Nourshargh S ( 1997 ) . TNFα and IFNγ act synergistically to induce leukocyte rolling and adhesion but not extravasation in vivo . FASEB Journal vol. 11 , ( 3 )
Sanz MJ, Hartnell A, Chisholm P, Williams C, Davies D, Weg VB, Feldmann M, Bolanowski MA et al. ( 1997 ) . Tumor necrosis factor α-induced eosinophil accumulation in rat skin is dependent on α<inf>4</inf> integrin/vascular cell adhesion molecule-1 adhesion pathways . Blood vol. 90 , ( 10 ) 4144 - 4152 .
Nourshargh S ( 1997 ) . Adhesion molecules and asthma . Journal of Pharmacy and Pharmacology . vol. 49 , 33 - 38 .
Wakelin MW, Sanz MJ, Dewar A, Albelda SM, Larkin SW, Boughton-Smith N, Williams TJ, Nourshargh S ( 1996 ) . An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane . Journal of Experimental Medicine vol. 184 , ( 1 ) 229 - 239 .
Nourshargh S, Larkin SW, Das A, Williams TJ ( 1995 ) . Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor . Blood vol. 85 , ( 9 ) 2553 - 2558 .
Sanz MJ, Weg VB, Bolanowski MA, Nourshargh S ( 1995 ) . IL-1 is a potent inducer of eosinophil accumulation in rat skin: Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody . Journal of Immunology vol. 154 , ( 3 ) 1364 - 1373 .
Weg VB, Walsh DT, Faccioli LH, Williams TJ, Feldmann M, Nourshargh S ( 1995 ) . LPS-induced <sup>111</sup>In-eosinophil accumulation in guinea-pig skin: Evidence for a role for TNF-α . Immunology vol. 84 , ( 1 ) 36 - 40 .
Das AM, Williams TJ, Lobb R, Nourshargh S ( 1995 ) . Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model . Immunology vol. 84 , ( 1 ) 41 - 46 .
Nourshargh S, Williams TJ ( 1995 ) . Molecular and cellular interactions mediating granulocyteaccumulation in vivo . Seminars in Cell Biology vol. 6 , ( 6 ) 317 - 326 .
Walsh DT, Weg VB, Williams TJ, Nourshargh S ( 1995 ) . Substance P‐induced inflammatory responses in guinea‐pig skin: The effect of specific NK<inf>1</inf> receptor antagonists and the role of endogenous mediators . British Journal of Pharmacology vol. 114 , ( 7 ) 1343 - 1350 .
Sanz MJ, Weg VB, Walsh DT, Williams TJ, Nourshargh S ( 1994 ) . Differential effects of the PAF receptor antagonist UK‐74,505 on neutrophil and eosinophil accumulation in guinea‐pig skin . British Journal of Pharmacology vol. 113 , ( 2 ) 513 - 521 .
Rossi AG, Pons F, Norman KE, Williams TJ, Nourshargh S ( 1994 ) . The role of PAF in platelet accumulation and oedema formation in rabbit skin . Journal of Lipid Mediators and Cell Signalling . vol. 10 , 119 - 121 .
Weg VB, Williams TJ, Lobb RR, Nourshargh S ( 1993 ) . A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo . Journal of Experimental Medicine vol. 177 , ( 2 ) 561 - 566 .
Yarwood H, Nourshargh S, Brain S, Williams TJ ( 1993 ) . Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action . British Journal of Pharmacology vol. 108 , ( 4 ) 959 - 966 .
Nourshargh S ( 1993 ) . Mechanisms of neutrophil and eosinophil accumulation in vivo . American Review of Respiratory Disease . vol. 148 ,
Pons F, Rossi AG, Norman KE, Williams TJ, Nourshargh S ( 1993 ) . Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505 . British Journal of Pharmacology vol. 109 , ( 1 ) 234 - 242 .
Nourshargh S, Perkins JA, Showell HJ, Matsushima K, Williams TJ, Collins PD ( 1992 ) . A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8 . Journal of Immunology vol. 148 , ( 1 ) 106 - 111 .
Von Uexkull C, Nourshargh S, Williams TJ ( 1992 ) . Comparative responses of human and rabbit interleukin-1 in vivo: Effect of a recombinant interleukin-1 receptor antagonist . Immunology vol. 77 , ( 4 ) 483 - 487 .
Seale JP, Nourshargh S, Hellewell PG, Williams TJ ( 1991 ) . Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung . British Journal of Pharmacology vol. 104 , ( 1 ) 251 - 257 .
WILLIAMS TJ, DAS A, von UEXKULL C, NOURSHARGH S ( 1991 ) . Neutrophils in Asthma . Annals of the New York Academy of Sciences vol. 629 , ( 1 ) 73 - 81 .
Faccioli LH, Nourshargh S, Moqbel R, Williams FM, Sehmi R, Kay AB, Williams TJ ( 1991 ) . The accumulation of <sup>111</sup>In-eosinophils induced by inflammatory mediators, in vivo . Immunology vol. 73 , ( 2 ) 222 - 227 .
Williams TJ, Von Uexkull C, Nourshargh S ( 1990 ) . Neutrophil-endothelial cell interactions in microvascular tone and permeability changes . European Journal of Pharmacology . vol. 183 ,
Nourshargh S, Williams TJ ( 1990 ) . Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo: Pretreatment of <sup>111</sup>In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo . Journal of Immunology vol. 145 , ( 8 ) 2633 - 2638 .
Nourshargh S, Rampart M, Hellewell PG, Jose PJ, Harlan JM, Edwards AJ, Williams TJ ( 1989 ) . Accumulation of <sup>111</sup>In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen . Journal of Immunology vol. 142 , ( 9 ) 3193 - 3198 .
Williams TJ, Brain SD, Hellewell PG, Jose PJ, Nourshargh S, Rampart M ( 1988 ) . Alteration in microvascular permeability induced by products released during inflammation . Progress in clinical and biological research vol. 263 , 55 - 69 .
Nourshargh S, Hoult JRS ( 1987 ) . Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion . British Journal of Pharmacology vol. 91 , ( 3 ) 557 - 568 .
Nourshargh S, Hoult JRS ( 1986 ) . Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors . European Journal of Pharmacology vol. 122 , ( 2 ) 205 - 212 .
Hoult JRS, Nourshargh S ( 1985 ) . Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis . British Journal of Pharmacology vol. 86 , ( 3 ) 533 - 537 .