Skip to main content
Research

Publications: Dr Ryan O'Shaughnessy

Tawfik SS, Thomas B, Robinson EJ, Ahmed R, Begum R, Khanam H, Kelsell D, O'Shaughnessy R et al. ( 2022 ) . Quality of life in Bangladeshi children and families with atopic eczema . BRITISH JOURNAL OF DERMATOLOGY . vol. 187 , E28 - E29 .
Hughes A, Thomas B, O'Toole E, O'Shaughnessy R ( 2022 ) . Reduced filaggrin expression is associated with increased BMP signalling . BRITISH JOURNAL OF DERMATOLOGY . vol. 186 , E221 - E222 .
O’Shaughnessy RFL ( 2021 ) . Understanding the paradoxical proinflammatory effects of an immunosuppressant . British Journal of Dermatology vol. 185 , ( 6 ) 1091 - 1092 .
Wotherspoon DJ, Rogerson C, O’Shaughnessy R ( 2021 ) . 111 Single cell RNA seq revealed altered cytoskeletal dynamics and the formation of cytoplasmic RNA-Lamin A bodies during keratinocyte terminal differentiation . Journal of Investigative Dermatology vol. 141 , ( 10 )
Hughes AJ, Thomas B, O’Toole EA, O’Shaughnessy R ( 2021 ) . 132 Increased BMP Signalling Correlates with Increased Eczema Severity . Journal of Investigative Dermatology vol. 141 , ( 10 )
Button R, Harwood C, O’Shaughnessy R ( 2021 ) . 282 Phosphoproteomic profiling of AKT-related changes in cutaneous squamous cell carcinoma identified DNA-dependent protein kinase (DNA-PK) and N-Myc downstream regulator 2 (NDRG2) as therapeutic vulnerabilities . Journal of Investigative Dermatology vol. 141 , ( 10 )
Hughes AJ, Thomas B, O'Toole EA, O'Shaughnessy R ( 2021 ) . Increased BMP Signalling Correlates with Increased Eczema Severity . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 141 , S170 - S170 .
Button R, Harwood C, O'Shaughnessy R ( 2021 ) . Phosphoproteomic profiling of AKT-related changes in cutaneous squamous cell carcinoma identified DNA-dependent protein kinase (DNA-PK) and N-Myc downstream regulator 2 (NDRG2) as therapeutic vulnerabilities . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 141 , S197 - S197 .
Wotherspoon DJ, Rogerson C, O'Shaughnessy R ( 2021 ) . Single cell RNA seq revealed altered cytoskeletal dynamics and the formation of cytoplasmic RNA-Lamin A bodies during keratinocyte terminal differentiation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 141 , S167 - S167 .
O’Shaughnessy RFL ( 2021 ) . Ceramide kinase-like protein, ‘the kinase that isn’t’, finds a role in skin cancer stress relief . British Journal of Dermatology vol. 185 , ( 1 ) 14 - 15 .
Wotherspoon D, Tommasi C, O'Shaughnessy R, Button R, Rogerson C ( 2021 ) . Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation . Cell Death and Differentiation
Hughes AJ, Tawfik SS, Baruah KP, O'Toole EA, O'Shaughnessy RFL ( 2020 ) . Tape Strips in Dermatology Research . Br J Dermatol
O'Shaughnessy R, Rogerson C, Wotherspoon D ( 2020 ) . Perspective: Controlling epidermal terminal differentiation with transcriptional bursting and RNA bodies . Journal of Developmental Biology vol. 8 , ( 4 )
O'Shaughnessy R ( 2020 ) . Ubiquitin, a novel therapeutic target in psoriasis? . British Journal of Dermatology
Tommasi C, Rogerson C, Depledge DP, Jones M, Naeem AS, Venturini C, Frampton D, Tutill HJ et al. ( 2020 ) . Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin . Journal of Investigative Dermatology vol. 140 , ( 4 ) 774 - 784.e11 .
O'Shaughnessy RFL ( 2019 ) . Understanding actinic keratosis to reduce squamous cell carcinoma incidence . British Journal of Dermatology
O'Shaughnessy R, Papaioannou E ( 2019 ) . Sonic Hedgehog-signalling limits chronic dermatitis via Gli2-driven immune regulatory function . Journal of Clinical Investigation
O'Shaughnessy RFL ( 2019 ) . Targeting tryptophan transport and breakdown in basal cell carcinoma . Br J Dermatol vol. 180 , ( 1 ) 16 - 17 .
O'SHAUGHNESSY RFL ( 2018 ) . Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts . British Journal of Dermatology
Rogerson C, O'Shaughnessy RF ( 2018 ) . Protein kinases involved in epidermal barrier formation: The AKT family and other animals . Exp Dermatol
Gutowska-Owsiak D, De La Serna JB, Fritzsche M, Naeem A, Podobas EI, Leeming M, Colin-York H, O'Shaughnessy R et al. ( 2018 ) . Orchestrated control of filaggrin-actin scaffolds underpins cornification . Cell Death and Disease vol. 9 , ( 4 )
Rogerson C, Bergamaschi D, O'Shaughnessy RFL ( 2017 ) . Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues . Nucleus1 - 9 .
Zhu Y, Underwood J, Macmillan D, Shariff L, O'Shaughnessy R, Harper JI, Pickard C, Friedmann PS et al. ( 2017 ) . Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity . Journal of Allergy and Clinical Immunology vol. 140 , ( 5 ) 1310 - 1322.e5 .
Janus JM, O’Shaughnessy RFL, Harwood CA, Maffucci T ( 2017 ) . Phosphoinositide 3-kinase-dependent signalling pathways in cutaneous squamous cell carcinomas . Cancers vol. 9 , ( 7 )
Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SAG, Moffatt M et al. ( 2017 ) . A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis . Journal of Allergy and Clinical Immunology vol. 139 , ( 4 ) 1228 - 1241 .
Duurland CL, Brown CC, O'Shaughnessy RFL, Wedderburn LR ( 2017 ) . CD161<sup>+</sup> Tconv and CD161<sup>+</sup> treg share a transcriptional and functional phenotype despite limited overlap in TCRβ repertoire . Frontiers in Immunology vol. 8 , ( MAR )
Akinduro O, Harwood CA, O'Shaughnessy R, Bergamaschi D ( 2016 ) . Epidermal autophagy and nucleophagy . JOURNAL OF INVESTIGATIVE DERMATOLOGY . Conference: European Society of Investigative Dermatology vol. 136 , S183 - S183 .
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP et al. ( 2016 ) . Constitutive Autophagy and Nucleophagy during Epidermal Differentiation . Journal of Investigative Dermatology vol. 136 , ( 7 ) 1460 - 1470 .
Thomas AC, Zeng Z, Rivière JB, O'Shaughnessy R, Al-Olabi L, St.-Onge J, Atherton DJ, Aubert H et al. ( 2016 ) . Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis . Journal of Investigative Dermatology vol. 136 , ( 4 ) 770 - 778 .
Naeem AS, Zhu Y, Di WL, Marmiroli S, O'Shaughnessy RFL ( 2015 ) . AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation . Cell Death and Differentiation vol. 22 , ( 12 ) 2123 - 2132 .
O'Shaughnessy RFL, Brown SJ ( 2015 ) . Insight from the air-skin interface . Journal of Investigative Dermatology vol. 135 , ( 2 ) 331 - 333 .
Kinsler VA, Drury S, Khan A, Waelchli R, Rukaite G, Barnicoat A, Lench N, Harper JI et al. ( 2015 ) . A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma . British Journal of Dermatology vol. 172 , ( 1 ) 262 - 264 .
Duurland C, Brooks T, Hubank M, O'Shaughnessy R, Wedderburn L ( 2014 ) . CD161+ regulatory t cells in immune regulation . Pediatric Rheumatology vol. 12 , ( Suppl 1 )
Youssef G, Ono M, Brown SJ, Kinsler VA, Sebire NJ, Harper JI, O'Shaughnessy RFL ( 2014 ) . Identifying a hyperkeratosis signature in autosomal recessive congenital Ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model . Journal of Investigative Dermatology vol. 134 , ( 3 ) 858 - 861 .
Duurland C, Chain G, O'Shaughnessy R, Pesenacker A, Wedderburn L ( 2013 ) . PReS-FINAL-1021: Further characterization of CD161+ regulatory t cells in health and disease . Pediatric Rheumatology vol. 11 , ( Suppl 2 )
Gerner L, Youssef G, O'Shaughnessy RFL ( 2013 ) . The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition . Experimental Dermatology vol. 22 , ( 11 ) 754 - 756 .
Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O'Neill CA, O'Shaughnessy RFL ( 2013 ) . Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition . Developmental Biology vol. 380 , ( 2 ) 274 - 285 .
Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C ( 2013 ) . The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling . Oncogene vol. 32 , ( 27 ) 3254 - 3262 .
Akinduro O, Sully K, Chikh A, O'shaughnessy RF, Bergamaschi D, Harwood CA, Philpott MP, Byrne C ( 2013 ) . Constitutive autophagy as a terminal differentiation mechanism . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 133 , S127 - S127 .
O'shaughnessy RFL, Chaudhury I, Harper JI ( 2013 ) . Insterleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of Lamellar ichthyosis . Human Molecular Genetics vol. 22 , ( 5 )
Furmanski AL, O'Shaughnessy RFL, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T ( 2013 ) . T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss . Journal of Investigative Dermatology vol. 133 , ( 5 ) 1221 - 1230 .
Akinduro O, Sully K, O'Shaughnessy R, Harwood CA, Bergamaschi D, Byrne C ( 2012 ) . A Novel Mechanism of Keratinocyte Terminal Differentiation - Autophagy? . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 132 , S78 - S78 .
Ekeowa-Anderson AL, Purdie KJ, Gibbon K, Byrne CR, Arbeit JM, Harwood CA, O'Shaughnessy RFL ( 2012 ) . AKT1 loss correlates with episomal HPV16 in Vulval intraepithelial neoplasia . PLoS ONE vol. 7 , ( 6 )
Akinduro O, Sully K, O'Shaughnessy RFL, Harwood CA, Bergamaschi D, Byrne C ( 2012 ) . Autophagy in epidermis . BRITISH JOURNAL OF DERMATOLOGY . vol. 166 , e31 - e31 .
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al. ( 2011 ) . TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier . Development vol. 138 , ( 11 ) 1681 - 1690 .
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al. ( 2011 ) . TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier . J Cell Sci vol. 124 , ( Pt 10 ) 1681 - 1690 .
Sully K, Akinduro O, O'Shaughnessy RF, Harwood CA, Byrne C ( 2011 ) . Understanding the tumour-suppressing role of rapamycin in epidermis . BRITISH JOURNAL OF DERMATOLOGY . vol. 164 , 909 - 909 .
Sully K, Akinduro OA, Philpott MP, Harwood CA, O'Shaughnessy RF, Byrne C ( 2011 ) . Rapamycin treatment increases mTORC2 activity and selectively activates the AKT1 isoform in epidermis by inhibition of the mTORC1-dependent feedback loop to IRS-1 . MOLECULAR BIOLOGY OF THE CELL . vol. 22 ,
O'Shaughnessy RFL, Choudhary I, Harper JI ( 2010 ) . Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis . Human Molecular Genetics vol. 19 , ( 13 ) 2594 - 2605 .
Byrne C, Avilion AA, O'Shaughnessy RF, Welti JC, Hardman MJ ( 2010 ) . Whole-mount assays for gene induction and barrier formation in the developing epidermis . Methods Mol Biol vol. 585 , 271 - 286 .
O'Shaughnessy RFL, Welti JC, Sully K, Byrne C ( 2009 ) . Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development . Development vol. 136 , ( 20 ) 3423 - 3431 .
O'Shaughnessy RFL, Welti JC, Byrne CR ( 2009 ) . AKT-dependent protein phosphatase 2A activity is necessary for epidermal barrier function and the correct formation of the cornified layer . BRITISH JOURNAL OF DERMATOLOGY . vol. 160 , 903 - 903 .
O'Shaughnessy RFL, Welti JC, Byrne CR ( 2008 ) . Akt-dependent, protein phosphatase 2A-mediated formation of tight junctions is an initial component of the epidermal permeability barrier . BRITISH JOURNAL OF DERMATOLOGY . vol. 158 , 879 - 879 .
O'Shaughnessy RFL, Akgũl B, Storey A, Pfister H, Harwood CA, Byrne C ( 2007 ) . Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors . Cancer Res vol. 67 , ( 17 ) 8207 - 8215 .
O'Shaughnessy RFL, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C ( 2007 ) . AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation . J Biol Chem vol. 282 , ( 23 ) 17297 - 17305 .
O'Shaughnessy RFL, Akgul B, Storey A, Pfister H, Harwood CA, Byrne C ( 2007 ) . Cutaneous human papillomavirus early genes downregulate serine phosphorylated Akt1 while upregulating Akt2 expression . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1109 - 1110 .
Welti JC, O'Shaughnessy RFL, Byrne C ( 2007 ) . Epidermal AKT signalling regulates SREBP transcription, epidermal lipogenesis and skin barrier activity . BRITISH JOURNAL OF DERMATOLOGY . vol. 156 , 1101 - 1102 .
O'Shaughnessy R, Welti J, Pfister H, Harwood C, Byrne C ( 2006 ) . Cutaneous HPV early genes target epidermal AKT activity, altering heat-shock protein regulation of cornification . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 126 , 108 - 108 .
O'Shaughnessy RFL, Yeo W, Gautier J, Jahoda CAB, Christiano AM ( 2004 ) . The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling . J Invest Dermatol vol. 123 , ( 4 ) 613 - 621 .
O'Shaughnessy RFL, Christiano AM, Jahoda CAB ( 2004 ) . The role of BMP signalling in the control of ID3 expression in the hair follicle . Experimental Dermatology vol. 13 , ( 10 ) 621 - 629 .
O'Shaughnessy RFL, Christiano AM ( 2004 ) . Inherited disorders of the skin in human and mouse: From development to differentiation . International Journal of Developmental Biology vol. 48 , ( 2-3 ) 171 - 179 .
Jahoda CAB, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M et al. ( 2004 ) . The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene . Genomics vol. 83 , ( 5 ) 747 - 756 .
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X et al. ( 2003 ) . Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris . Cell vol. 113 , ( 2 ) 249 - 260 .
O'Shaughnessy RFL, Christiano AM ( 2001 ) . Stem cells in the epidermis . Skin Pharmacology and Applied Skin Physiology vol. 14 , ( 6 ) 350 - 357 .
Aberger F, Costa-Pereira AP, Schlaak JF, Williams TM, O'Shaughnessy RFL, Hollaus G, Kerr IM, Frischauf AMM ( 2001 ) . Analysis of gene expression using high-density and IFN-γ-specific low-density cDNA arrays . Genomics vol. 77 , ( 1-2 ) 50 - 57 .
O'Shaughnessy RFL, Seery JP, Celis JE, Frischauf AM, Watt FM ( 2000 ) . PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation . FEBS Letters vol. 486 , ( 2 ) 149 - 154 .