Publications: Prof Eric Parkinson

Schwertner B, Dahdal G, Jagla W, Grossmann L, Drexler K, Krahn MP, Evert K, Berneburg M et al. ( 2024 ) . Expression of the plasma membrane citrate carrier (pmCiC) in human cancerous tissues—correlation with tumour aggressiveness . Frontiers in Cell and Developmental Biology vol. 12 ,

Prime SS, Darski P, Hunter KD, Cirillo N, Parkinson EK ( 2024 ) . A Review of the Repair of DNA Double Strand Breaks in the Development of Oral Cancer . International Journal of Molecular Sciences vol. 25 , ( 7 )

Bertram MJ, Bérubé NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ et al. ( 2023 ) . Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes . Molecular and Cellular Biology vol. 19 , ( 2 ) 1479 - 1485 .

James EN, Sagi-Kiss V, Bennett M, Mycielska ME, Karen-Ng LP, Roberts T, Matta S, Dokal I et al. ( 2023 ) . Dyskeratosis Congenita Links Telomere Attrition to Age-Related Systemic Energetics . The Journals of Gerontology Series A vol. 78 , ( 5 ) 780 - 789 .

Prime SS, Cirillo N, Parkinson EK ( 2023 ) . Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy . Biology vol. 12 , ( 1 )

Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP, Braun KM ( 2022 ) . Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures . Journal of Dentistry vol. 125 ,

Tan ML, Parkinson EK, Yap LF, Paterson IC ( 2022 ) . Author Correction: Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-β1 . Scientific Reports vol. 12 , ( 1 )

Melo G, Silva CAB, Hague A, Parkinson EK, Rivero ERC ( 2022 ) . Anticancer effects of putative and validated BH3-mimetic drugs in head and neck squamous cell carcinomas: An overview of current knowledge . Oral Oncology vol. 132 ,

Parkinson EK, Haferkamp S, Mycielska ME ( 2022 ) . Cancer Cell Metabolism . International Journal of Molecular Sciences vol. 23 , ( 13 )

Karen-Ng LP, Ahmad US, Gomes L, Hunter KD, Wan H, Hagi-Pavli E, Parkinson EK ( 2022 ) . Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes . Cancers vol. 14 , ( 11 )

Ganapathy V, Haferkamp S, Parkinson EK, Mycielska ME ( 2022 ) . Editorial: Metabolite and Nutrient Transporters in Cancer-Cell Metabolism: Role in Cancer Progression and Metastasis . Frontiers in Cell and Developmental Biology vol. 10 ,

Parkinson EK, Prime SS ( 2022 ) . Oral Senescence: From Molecular Biology to Clinical Research . Frontiers in Dental Medicine vol. 3 ,

Mycielska ME, James EN, Parkinson EK ( 2022 ) . Metabolic Alterations in Cellular Senescence: The Role of Citrate in Ageing and Age-Related Disease . International Journal of Molecular Sciences vol. 23 , ( 7 )

Ahmad US, Parkinson EK, Wan H ( 2022 ) . Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells . Molecular Oncology vol. 16 , ( 8 ) 1625 - 1649 .

Huang Y, Jedlickova H, Cai Y, Rehman A, Gammon L, Ahmad US, Uttagomol J, Chance R et al. ( 2022 ) . Oxidative stress-mediated yes-associated protein dysregulation contributes to the pathogenesis of pemphigus vulgaris . BRITISH JOURNAL OF DERMATOLOGY . vol. 187 , E43 - E44 .

Parkinson EK, Adamski J, Zahn G, Gaumann A, Flores-Borja F, Ziegler C, Mycielska ME ( 2021 ) . Extracellular citrate and metabolic adaptations of cancer cells . Cancer and Metastasis Reviews vol. 40 , ( 4 ) 1073 - 1091 .

Agha A, Parker S, Parkinson EK, Patel M ( 2021 ) . Characteristics of experimental resin-modified glass-ionomer cements, containing alternate monomers to HEMA . Dental Materials vol. 37 , ( 10 ) 1542 - 1552 .

Karen-Ng LP, James EL, Stephen A, Bennett MH, Mycielska ME, Parkinson EK ( 2021 ) . The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression . Cancers vol. 13 , ( 16 )

Prime SS, Cirillo N, Cheong SC, Prime MS, Parkinson EK ( 2021 ) . Targeting the genetic landscape of oral potentially malignant disorders has the potential as a preventative strategy in oral cancer . Cancer Letters vol. 518 , 102 - 114 .

Huang Y, Jedličková H, Cai Y, Rehman A, Gammon L, Ahmad US, Uttagomol J, Parkinson EK et al. ( 2021 ) . Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris . Frontiers in Immunology vol. 12 ,

Drexler K, Schmidt KM, Jordan K, Federlin M, Milenkovic VM, Liebisch G, Artati A, Schmidl C et al. ( 2021 ) . Cancer-associated cells release citrate to support tumour metastatic progression . Life Science Alliance vol. 4 , ( 6 )

Tan ML, Parkinson EK, Yap LF, Paterson IC ( 2021 ) . Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF-β1 . Scientific Reports vol. 11 , ( 1 )

Haferkamp S, Drexler K, Federlin M, Schlitt HJ, Berneburg M, Adamski J, Gaumann A, Geissler EK et al. ( 2020 ) . Extracellular Citrate Fuels Cancer Cell Metabolism and Growth . Frontiers in Cell and Developmental Biology vol. 8 , 602476 - 602476 .

Mello FW, Kammer PV, Silva CAB, Parkinson EK, Monteiro L, Warnakulasuriya S, Rivero ERC ( 2020 ) . Prognostic and clinicopathological significance of podoplanin immunoexpression in oral and oropharyngeal squamous cell carcinoma: A systematic review . Journal of Oral Pathology and Medicine vol. 50 , ( 1 ) 1 - 9 .

Houacine S, Kang A, Parkinson EK, Wan H, Fortune F ( 2020 ) . Induction of p53 in keratinocyte cultures treated with Behçet's patient sera . Journal of Oral Pathology and Medicine vol. 49 , ( 5 ) 435 - 442 .

Lai SL, Tan ML, Hollows RJ, Robinson M, Ibrahim M, Margielewska S, Parkinson EK, Ramanathan A et al. ( 2019 ) . Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1 . Cancers vol. 11 , ( 11 )

Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al. ( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development

Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al. ( 2019 ) . The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 . Cell Death & Disease vol. 10 , ( 10 )

Veeramachaneni R, Walker T, Revil T, Weck AD, Badescu D, O’Sullivan J, Higgins C, Elliott L et al. ( 2019 ) . Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy . Scientific Reports vol. 9 , ( 1 )

PARKINSON E, JAMES E, Bennett M ( 2018 ) . The induction of the fibroblast extracellular senescence metabolome is a dynamic process . Scientific Reports

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF et al. ( 2018 ) . Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype . Carcinogenesis vol. 39 , ( 8 ) 1094 - 1094 .

Tan ML, Parkinson EK, Yap LF, Paterson IC ( 2018 ) . Abstract 458: Relationship between autophagy, activation and senescence in normal and cancer-associated human oral fibroblasts . Cancer Research . vol. 78 , 458 - 458 .

Kuo M, Irving RM, Parkinson EK ( 2018 ) . Molecular biology . Scott-Brown's Otorhinolaryngology and Head and Neck Surgery , vol. 1 ,

Bergmeier LA, Parkinson EK ( 2018 ) . Future Directions of Research in the Oral Mucosa . Oral Mucosa in Health and Disease , Springer Nature

Kenneth Parkinson E ( 2018 ) . Oral Cancer: Recent Developments and Future Challenges . Oral Mucosa in Health and Disease , Springer Nature

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF et al. ( 2018 ) . A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype . Carcinogenesis vol. 39 , ( 6 ) 798 - 807 .

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J ( 2018 ) . INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES . WOUND REPAIR AND REGENERATION . vol. 26 , A30 - A31 .

Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J, Braun KM ( 2018 ) . Investigating the differences in the wound healing responses of skin and gingival keratinocytes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E416 - E416 .

James EL, Lane JAE, Michalek RD, Karoly ED, Parkinson EK ( 2016 ) . Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism . Scientific Reports vol. 6 , 38489 - 38489 .

Cirillo N, Hassona Y, Celentano A, Lim KP, Manchella S, Parkinson EK, Prime SS ( 2016 ) . Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-ß-dependent pathways in genotype-specific oral cancer . Carcinogenesis vol. 38 , ( 1 ) Article 2503219 , 76 - 85 .

PARKINSON EK ( 2016 ) . A miR‐335/COX‐2/PTEN axis regulates the secretory phenotype of senescent cancerassociated fibroblasts . Aging

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James ENL et al. ( 2016 ) . Fibroblast activation and senescence in oral cancer . Journal Of Oral Pathology and Medicine

Parkinson EK, James EL, Prime SS ( 2015 ) . Senescence-Derived Extracellular Molecules as Modulators of Oral Cancer Development: A Mini-Review . Gerontology vol. 62 , ( 4 ) 417 - 424 .

Rehman A, Ali S, Lone MA, Atif M, Hassona Y, Prime SS, Pitiyage GN, James ELN et al. ( 2015 ) . Areca nut alkaloids induce irreparable DNA damage and senescence in fibroblasts and may create a favourable environment for tumour progression . Journal of Oral Pathology and Medicine vol. 45 , ( 5 ) 365 - 372 .

James EL, Parkinson EK ( 2015 ) . Serum metabolomics in animal models and human disease . Current Opinion in Clinical Nutrition & Metabolic Care vol. 18 , ( 5 ) 478 - 483 .

Dale TP, de Castro A, Kuiper NJ, Parkinson EK, Forsyth NR ( 2015 ) . Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner . PLOS ONE vol. 10 , ( 7 )

Rivero ERC, Hassona Y, Prime SS, Parkinson EK ( 2015 ) . Senescence Induced by Ethanol in Oral Fibroblasts . Oral Surgery Oral Medicine Oral Pathology and Oral Radiology vol. 119 , ( 3 ) e120 - e121 .

James EL, Michalek RD, Pitiyage GN, de Castro AM, Vignola KS, Jones J, Mohney RP, Karoly ED et al. ( 2015 ) . Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease . Journal of Proteome Research vol. 14 , ( 4 ) 1854 - 1871 .

de Castro A, Minty F, Hattinger E, Wolf R, Parkinson EK ( 2014 ) . The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators . Longevity & Healthspan vol. 3 , ( 1 )

Hassona Y, Cirillo N, Heesom K, Parkinson EK, Prime SS ( 2014 ) . Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion . Br J Cancer vol. 111 , ( 6 ) 1230 - 1237 .

Dale TP, De Castro A, Parkinson EK, Kuiper NJ, Forsyth NR ( 2014 ) . Immortalisation with hTERT impacts on sulphated glycosaminoglycan secretion and chondrogenic potential in a variable and cell specific manner . JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE vol. 8 , 366 - 366 .

Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT, Parkinson EK ( 2013 ) . Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2 . Carcinogenesis vol. N/A , Article N/A , 1 - 38 .

Hassona Y, Cirillo N, Lim KP, Herman A, Mellone M, Thomas GJ, Pitiyage GN, Parkinson EK et al. ( 2013 ) . Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-β . Carcinogenesis vol. 34 , ( 6 ) 1286 - 1295 .

Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK ( 2013 ) . The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin . Toxicol Lett vol. 218 , ( 2 ) 150 - 158 .

Pitiyage GN, Lim KP, Gemenitzidis E, Teh M-T, Waseem A, Prime SS, Tilakaratne WM, Fortune F et al. ( 2012 ) . Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indicators of oral sub-mucous fibrosis and ageing . J Oral Pathol Med vol. 41 , ( 6 ) 454 - 462 .

Hunter K, Parkinson EK, Thakker N ( 2011 ) . An overview of the molecular pathology of head and neck cancer, and its clinical implications . Periodontology 2000 vol. 57 , ( 1 ) 132 - 149 .

Pitiyage GN, Slijepcevic P, Gabrani A, Chianea YG, Lim KP, Prime SS, Tilakaratne WM, Fortune F et al. ( 2011 ) . Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases . J Pathol vol. 223 , ( 5 ) 604 - 617 .

Lim KP, Cirillo N, Hassona Y, Wei WB, Thurlow JK, Cheong SC, Pitiyage G, Parkinson EK et al. ( 2011 ) . Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma . J PATHOL vol. 223 , ( 4 ) 459 - 469 .

( 2011 ) . Correction: Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 71 , ( 1 ) 290 - 290 .

Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H ( 2011 ) . A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma . J Oral Pathol Med vol. 40 , ( 1 ) 67 - 76 .

Parkinson EK ( 2010 ) . Senescence as a modulator of oral squamous cell carcinoma development . Oral Oncol vol. 46 , ( 12 ) 840 - 853 .

Thurlow JK, Peña Murillo CL, Hunter KD, Buffa FM, Patiar S, Betts G, West CML, Harris AL et al. ( 2010 ) . Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma . J Clin Oncol vol. 28 , ( 17 ) 2881 - 2888 .

Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H, Teh MT ( 2010 ) . Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1 . Cancer Research vol. 70 , ( 22 ) Article N/A , 9515 - 9526 .

Nikolakopoulou Z, Michael-Titus AT, Parkinson EK ( 2009 ) . Abstract B152: The selective effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis . Molecular Cancer Therapeutics . vol. 8 , b152 - b152 .

Parkinson EK, Hume WJ, Potten CS ( 2009 ) . The Radiosensitivity of Cultured Human and Mouse Keratinocytes . International Journal of Radiation Biology vol. 50 , ( 4 ) 717 - 726 .

Syed ML, Syed S, Minty F, Harrower S, Singh J, Chin A, McLellan DR, Parkinson EK et al. ( 2009 ) . Gamma tubulin: A promising indicator of recurrence in squamous cell carcinoma of the larynx . OTOLARYNG HEAD NECK vol. 140 , ( 4 ) 498 - 504 .

Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK et al. ( 2009 ) . FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation . PLoS One vol. 4 , ( 3 )

Maclntyre A, Brouilette SW, Lamb K, Radhakrishnan K, McGlynn L, Chee MM, Parkinson EK, Freeman D et al. ( 2008 ) . Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion . ANN RHEUM DIS vol. 67 , ( 12 ) 1780 - 1782 .

Minty F, Thurlow JK, Harrison PR, Parkinson EK ( 2008 ) . Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile . Exp Cell Res vol. 314 , ( 13 ) 2434 - 2447 .

Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E et al. ( 2008 ) . Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis . J ORAL PATHOL MED vol. 37 , ( 6 ) 372 - 377 .

Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK et al. ( 2008 ) . An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity . J ORAL PATHOL MED vol. 37 , ( 4 ) 211 - 220 .

McCaul JA, Gordon KE, Minty F, Fleming J, Parkinson EK ( 2008 ) . Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells . Oral Oncol vol. 44 , ( 3 ) 261 - 269 .

Parkinson EK, Fitchett C, Cereser B ( 2008 ) . Dissecting the non-canonical functions of telomerase . Cytogenet Genome Res vol. 122 , ( 3-4 ) 273 - 280 .

Syed MI, Syed S, Harrower S, Singh J, Chin A, McLellan D, Parkinson EK, Clark LJ ( 2007 ) . Abstracts of the Autumn 2007 Meeting of the Otorhinolaryngological Research Society . Clinical Otolaryngology vol. 32 , ( 6 ) 511 - 511 .

CLARK LJ, MacKENZIE K, PARKINSON EK ( 2007 ) . Elevated levels of the p53 tumour suppressor protein in the basal layer of recurrent laryngeal papillomas . Clinical Otolaryngology vol. 18 , ( 1 ) 63 - 65 .

PROOPS DW, PARKINSON EK ( 2007 ) . Tissue culture of human cholesteatomatous keratinocytes . Clinical Otolaryngology vol. 8 , ( 3 ) 165 - 170 .

Parkinson EK, Minty F ( 2007 ) . Anticancer therapy targeting telomeres and telomerase : current status . BioDrugs vol. 21 , ( 6 ) 375 - 385 .

Hunter KD, Thurlow JK, Fleming J, Drake PJH, Vass JK, Kalna G, Higham DJ, Herzyk P et al. ( 2006 ) . Divergent routes to oral cancer . Cancer Res vol. 66 , ( 15 ) 7405 - 7413 .

Edington KG, Loughran OP, Berry IJ, Parkinson EK ( 2006 ) . Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss . Molecular Carcinogenesis vol. 13 , ( 4 ) 254 - 265 .

Berry IJ, Burns JE, Parkinson EK ( 2006 ) . Assignment of two human epidermal squamous cell carcinoma cell lines to more than one complementation group for the immortal phenotype . Molecular Carcinogenesis vol. 9 , ( 3 ) 134 - 142 .

Brown KW, Parkinson EK ( 2006 ) . Alteration of the extracellular matrix of cultured human keratinocytes by transformation and during differentiation . International Journal of Cancer vol. 35 , ( 6 ) 799 - 807 .

Parkinson EK, Newbold RF ( 2006 ) . Benzo(a)pyrene metabolism and DNA adduct formation in serially cultivated strains of human epidermal keratinocytes . International Journal of Cancer vol. 26 , ( 3 ) 289 - 299 .

Brown KW, Parkinson EK ( 2006 ) . Extracellular matrix components produced by SV40‐transformed human epidermal keratinocytes . International Journal of Cancer vol. 33 , ( 2 ) 257 - 263 .

Stanley MA, Parkinson EK ( 2006 ) . Growth requirements of human cervical epithelial cells in culture . International Journal of Cancer vol. 24 , ( 4 ) 407 - 414 .

Pring M, Prime S, Parkinson EK, Paterson I ( 2006 ) . Dysregulated TGF-beta 1-induced Smad signalling occurs as a result of defects in multiple components of the TGF-beta signalling pathway in human head and neck carcinoma cell lines . INT J ONCOL vol. 28 , ( 5 ) 1279 - 1285 .

Sedghizadeh PP, Mallery SR, Thompson SJ, Kresty L, Beck FM, Parkinson EK, Biancamano J, Lang JC ( 2006 ) . Expression of the serine protease Desc1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression . HEAD NECK-J SCI SPEC vol. 28 , ( 5 ) 432 - 440 .

Parkinson KE ( 2005 ) . Telomerase as a target for cancer therapy . Current Opinion in Investigational Drugs vol. 6 , ( 6 ) 605 - 610 .

Roberts RA, Spooncer E, Parkinson EK, Lord BI, Allen TD, Dexter TM ( 2005 ) . Metabolically inactive 3T3 cells can substitute for marrow stromal cells to promote the proliferation and development of multipotent haemopoietic stem cells . Journal of Cellular Physiology vol. 132 , ( 2 ) 203 - 214 .

Hunter KD, Parkinson EK, Harrison PR ( 2005 ) . Profiling early head and neck cancer . Nat Rev Cancer vol. 5 , ( 2 ) 127 - 135 .

Munro J, Barr NI, Ireland H, Morrison V, Parkinson EK ( 2004 ) . Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock . Exp Cell Res vol. 295 , ( 2 ) 525 - 538 .

Scott LA, Vass JK, Parkinson EK, Gillespie DAF, Winnie JN, Ozanne BW ( 2004 ) . Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53 . Mol Cell Biol vol. 24 , ( 4 ) 1540 - 1559 .

Gordon KE, Parkinson EK ( 2004 ) . Analysis of telomerase activity and telomere function in cancer . Methods Mol Biol vol. 281 , 333 - 348 .

Muntoni A, Fleming J, Gordon KE, Hunter K, McGregor F, Parkinson EK, Harrison PR ( 2003 ) . Senescing oral dysplasias are not immortalized by ectopic expression of hTERT alone without other molecular changes, such as loss of INK4A and/or retinoic acid receptor-beta: but p53 mutations are not necessarily required . Oncogene vol. 22 , ( 49 ) 7804 - 7808 .

Wootton M, Steeghs K, Watt D, Munro J, Gordon K, Ireland H, Morrison V, Behan W et al. ( 2003 ) . Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability . HUM GENE THER vol. 14 , ( 15 ) 1473 - 1487 .

Fitzsimmons SA, Ireland H, Barr NI, Cuthbert AP, Going JJ, Newbold RF, Parkinson EK ( 2003 ) . Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15 . Oncogene vol. 22 , ( 11 ) 1737 - 1746 .

Gordon KE, Ireland H, Roberts M, Steeghs K, McCaul JA, MacDonald DG, Parkinson EK ( 2003 ) . High levels of telomere dysfunction bestow a selective disadvantage during the progression of human oral squamous cell carcinoma . Cancer Res vol. 63 , ( 2 ) 458 - 467 .

Parkinson EK ( 2003 ) . Telomerase as a novel and potentially selective target for cancer chemotherapy . Ann Med vol. 35 , ( 7 ) 466 - 475 .

McGregor F, Muntoni A, Fleming J, Brown J, Felix DH, MacDonald DG, Parkinson EK, Harrison PR ( 2002 ) . Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine . Cancer Res vol. 62 , ( 16 ) 4757 - 4766 .

Forsyth NR, Morrison V, Craig NJ, Fitzsimmons SA, Barr NI, Ireland H, Gordon KE, Dowen S et al. ( 2002 ) . Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4 . Oncogene vol. 21 , ( 33 ) 5135 - 5147 .

McCaul JA, Gordon KE, Clark LJ, Parkinson EK ( 2002 ) . Telomerase inhibition and the future management of head-and-neck cancer . Lancet Oncol vol. 3 , ( 5 ) 280 - 288 .

Parkinson EK, Yeudall WA ( 2002 ) . The Epidermis . Culture of Epithelial Cells , Wiley

Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, Eveson JW, Robinson CM et al. ( 2002 ) . TGF-beta 1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest . ONCOGENE vol. 21 , ( 10 ) 1616 - 1624 .

Bryce SD, Morrison V, Craig NJ, Forsyth NR, Fitzsimmons SA, Ireland H, Cuthbert AP, Newbold RF et al. ( 2002 ) . A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23 . Neoplasia vol. 4 , ( 6 ) 544 - 550 .

Snaddon J, Parkinson EK, Craft JA, Bartholomew C, Fulton R ( 2001 ) . Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus . BRIT J CANCER vol. 84 , ( 12 ) 1630 - 1634 .

Munro J, Steeghs K, Morrison V, Ireland H, Parkinson EK ( 2001 ) . Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres . Oncogene vol. 20 , ( 27 ) 3541 - 3552 .

Paterson IC, Matthews JB, Huntley S, Robinson CM, Fahey M, Parkinson EK, Prime SS ( 2001 ) . Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma . J PATHOL vol. 193 , ( 4 ) 458 - 467 .

Owens DW, Brunton VG, Parkinson EK, Frame MC ( 2000 ) . E-Cadherin at the Cell Periphery Is a Determinant of Keratinocyte Differentiation in Vitro . Biochemical and Biophysical Research Communications vol. 269 , ( 2 ) 369 - 376 .

Parkinson EK, Munro J, Steeghs K, Morrison V, Ireland H, Forsyth N, Fitzsimmons S, Bryce S ( 2000 ) . Replicative senescence as a barrier to human cancer . Biochemical Society Transactions . vol. 28 , 226 - 233 .

Owens DW, McLean GW, Wyke AW, Paraskeva C, Parkinson EK, Frame MC, Brunton VG ( 2000 ) . The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell–Cell Contacts . Molecular Biology of the Cell vol. 11 , ( 1 ) 51 - 64 .

Agochiya M, Brunton VG, Owens DW, Parkinson EK, Paraskeva C, Keith WN, Frame MC ( 1999 ) . Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells . Oncogene vol. 18 , ( 41 ) 5646 - 5653 .

Munro J, Stott FJ, Vousden KH, Peters G, Parkinson EK ( 1999 ) . Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization . Cancer Research vol. 59 , ( 11 ) 2516 - 2521 .

Bryce SD, Forsyth NR, Fitzsimmons SA, Clark LJ, Bertram MJ, Cuthbert AP, Newbold RF, Pereira-Smith OM et al. ( 1999 ) . Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene . Cancer Research vol. 59 , ( 9 ) 2038 - 2040 .

Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D et al. ( 1999 ) . Telomere-dependent senescence . Nature Biotechnology vol. 17 , ( 4 ) 313 - 313 .

Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK, Black DM ( 1999 ) . Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines . Oncogene vol. 18 , ( 10 ) 1881 - 1890 .

Cuthbert AP, Bond J, Trott DA, Gill S, Broni J, Marriott A, Khoudoli G, Parkinson EK et al. ( 1999 ) . Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells . Journal of the National Cancer Institute vol. 91 , ( 1 ) 37 - 45 .

Prime SS, Eveson JW, Guest PG, Parkinson EK, Paterson IC ( 1997 ) . Early genetic and functional events in the pathogenesis of oral cancer . International Journal of Cancer . vol. 5 , 93 - 96 .

Zhao J-Q, Hoare SF, McFarlane R, Muir S, Parkinson EK, Black DM, Keith WN ( 1998 ) . Cloning and characterization of human and mouse telomerase RNA gene promoter sequences . Oncogene vol. 16 , ( 10 ) 1345 - 1350 .

Loughran O, Clark LJ, Bond J, Baker A, Berry IJ, Edington KG, Ly I-S, Simmons R et al. ( 1997 ) . Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes . Oncogene vol. 14 , ( 16 ) 1955 - 1964 .

Soder AI, Hoare SF, Muire S, Balmain A, Parkinson EK, Keith WN ( 1997 ) . Mapping of the Gene for the Mouse Telomerase RNA Component,Terc,to Chromosome 3 by Fluorescencein SituHybridization and Mouse Chromosome Painting . Genomics vol. 41 , ( 2 ) 293 - 294 .

Parkinson EK, Newbold RF, Keith WN ( 1997 ) . The genetic basis of human keratinocyte immortalisation in squatnous cell carcinoma development: The role of telomerase reactivation . European Journal of Cancer vol. 33 , ( 5 ) 727 - 734 .

Soder AI, Hoare SF, Muir S, Going JJ, Parkinson EK, Keith WN ( 1997 ) . Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer . Oncogene vol. 14 , ( 9 ) 1013 - 1021 .

Loughran Ö, Malliri A, Owens D, Ozanne B, Frame M, Parkinson E ( 1996 ) . EVIDENCE FOR A ROLE FOR P16 IN REPLICATIVE SENESCENCE AND IMMORTALITY IN HUMAN KERATINOCYTES . Biochemical Society Transactions vol. 24 , ( 4 ) 550s - 550s .

Fahey M, Paterson I, Stone A, Collier A, Heung Y, Davies M, Patel V, Parkinson E et al. ( 1996 ) . Dysregulation of autocrine TGF-beta isoform production and ligand responses in human tumour-derived and Ha-ras-transfected keratinocytes and fibroblasts . British Journal of Cancer vol. 74 , ( 7 ) 1074 - 1080 .

Malliri A, Yeudall WA, Nikolic M, Crouch DH, Parkinson EK, Ozanne B ( 1996 ) . Sensitivity to transforming growth factor beta 1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC down-regulation and p21waf1 induction are important early events . Molecular Cancer Research vol. 7 , ( 10 ) 1291 - 1304 .

Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B, Frame MC, Parkinson EK ( 1996 ) . Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia . Oncogene vol. 13 , ( 3 ) 561 - 568 .

Parkinson E ( 1996 ) . Do telomerase antagonists represent a novel anti-cancer strategy? . British Journal of Cancer vol. 73 , ( 1 ) 1 - 4 .

Loughran O, Edington KG, Berry IJ, Clark LJ, Parkinson EK ( 1994 ) . Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes . Cancer Research vol. 54 , ( 19 ) 5045 - 5049 .

Burns J, Clark L, Yeudall W, Mitchell R, Mackenzie K, Chang S, Parkinson E ( 1994 ) . The p53 status of cultured human premalignant oral keratinocytes . British Journal of Cancer vol. 70 , ( 4 ) 591 - 595 .

Stanton P, Richards S, Reeves J, Nikolic M, Edington K, Clark L, Robertson G, Souter D et al. ( 1994 ) . Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenografts . British Journal of Cancer vol. 70 , ( 3 ) 427 - 433 .

Burns JE, McFarlane R, Clark LJ, Clark LJ, Mitchell R, Robertson G, Soutar D, Parkinson EK ( 1994 ) . Maintenance of identical p53 mutations throughout progression of squamous cell carcinomas of the tongue . Oral Oncology vol. 30 , ( 5 ) 335 - 337 .

Clark L, Edington K, Swan I, McLay K, Newlands W, Wills L, Young H, Johnston P et al. ( 1993 ) . The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck . British Journal of Cancer vol. 68 , ( 3 ) 617 - 620 .

Parkinson EK, Graham GJ, Daubersies P, Burns JE, Heufler C, Plumb M, Schuler G, Pragnell IB ( 1993 ) . Hemopoietic Stem Cell Inhibitor (SCI/MIP-1∝) Also Inhibits Clonogenic Epidermal Keratinocyte Proliferation . Journal of Investigative Dermatology vol. 101 , ( 2 ) 113 - 117 .

Burns J, Baird M, Clark L, Burns P, Edington K, Chapman C, Mitchell R, Robertson G et al. ( 1993 ) . Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines . British Journal of Cancer vol. 67 , ( 6 ) 1274 - 1284 .

Parkinson EK ( 1992 ) . Epidermal keratinocyte stem cells: their maintenance and regulation . Seminars in Cell and Developmental Biology vol. 3 , ( 6 ) 435 - 444 .

Appleby MW, Greenfield IM, Crook T, Parkinson EK, Stanley MA ( 1989 ) . In vivo and in vitro effects of v-fos and EJ-Ha-ras oncogene expression in murine epidermal keratinocytes . Oncogene vol. 4 , ( 11 ) 1323 - 1330 .

Parkinson EK ( 1989 ) . The transformation of human epidermal keratinocytes by carcinogens and viruses in vitro . Carcinogenesis: A Comprehensive Survey vol. 11 , 349 - 368 .

Parkinson EK, Al-Yaman FM, Appleby MW ( 1987 ) . The effect of donor age on the proliferative response of human and mouse keratinocytes to phorbol, 12-myristate, 13-acetate . Carcinogenesis vol. 8 , ( 7 ) 907 - 912 .

Parkinson EK ( 1987 ) . Phospholipase C mimics the differential effects of phorbol-12-myristate-13-acetate on the colony formation and cornification of cultured normal and transformed human keratinocytes . Carcinogenesis vol. 8 , ( 6 ) 857 - 860 .

Parkinson EK, Hume WJ, Potten CS ( 1986 ) . The radiosensitivity of keratinocytes from tongue and skin; enhanced radioresistance following serial cultivation . British Journal of Cancer vol. 53 , ( SUPPL. 7 ) 81 - 83 .

Parkinson EK ( 1985 ) . Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding . British Journal of Cancer vol. 52 , ( 4 ) 479 - 493 .

Stanley MA, Crowcroft NS, Quigley JP, Parkinson EK ( 1985 ) . Responses of human cervical keratinocytes in vitro to tumour promoters and diethylstilboestrol . Carcinogenesis vol. 6 , ( 7 ) 1011 - 1015 .

Brown KW, Parkinson EK ( 1985 ) . Fibronectin Production by Cultured Keratinocytes . Journal of Investigative Dermatology vol. 84 , ( 4 )

Potten CS, Hume WJ, Parkinson EK ( 1984 ) . MIGRATION AND MITOSIS IN THE EPIDERMIS . British Journal of Dermatology vol. 111 , ( 6 ) 695 - 699 .

Parkinson EK, Pera MF, Emmerson A, Gorman PA ( 1984 ) . Differential effects of complete and second-stage tumour promoters in normal but not transformed human and mouse keratinocytes . Carcinogenesis vol. 5 , ( 8 ) 1071 - 1077 .

Parkinson EK, Emmerson A ( 1984 ) . Non-promoting hyperplasiogenic agents do not mimic the effects of phorbol, 12-myristate, 13-acetate on terminal differentiation of normal and transformed human keratinocytes . Carcinogenesis vol. 5 , ( 5 ) 687 - 690 .

Proops DW, Hawke WM, Parkinson EK ( 1984 ) . Tissue culture of migratory skin of the external ear and cholesteatoma: a new research tool . Journal of Otolaryngology vol. 13 , ( 2 ) 63 - 69 .

Nigel JL, Parkinson EK, Emmerson A ( 1984 ) . Benzoyl peroxide interferes with metabolic co-operation between cultured human epidermal keratinocytes . Carcinogenesis vol. 5 , ( 3 ) 419 - 421 .

BARNHILL RL, PARKINSON EK, RYAN TJ ( 1984 ) . Supernatants from cultured human epidermal keratinocytes stimulate angiogenesis . British Journal of Dermatology vol. 110 , ( 3 ) 273 - 281 .

Brown KW, Parkinson EK ( 1983 ) . Glycoproteins and glycosaminoglycans of cultured normal human epidermal keratinocytes . Journal of Cell Science vol. 61 , ( 1 ) 325 - 338 .

Parkinson EK, Grabham P, Emmerson A ( 1983 ) . A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation . Carcinogenesis vol. 4 , ( 7 ) 857 - 861 .

Parkinson EK, Emmerson A ( 1982 ) . The effects of tumour promoters on the multiplication and morphology of cultured human epidermal keratinocytes . Carcinogenesis vol. 3 , ( 5 ) 525 - 531 .

Macartney JC, Parkinson EK ( 1981 ) . The ultrastructure of whole cells from two human keratinocyte strains during cell spreading and island formation in vitro . Experimental Cell Research vol. 132 , ( 2 ) 411 - 421 .

Paraskeva C, Parkinson EK ( 1981 ) . Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity . Carcinogenesis vol. 2 , ( 6 ) 483 - 487 .

Parkinson EK ( 1981 ) . The effects of phorbol esters and mezerein on growth and differentiation of human epidermal keratinocytes . Proceedings of the American Association for Cancer Research vol. Vol. 22 ,

Parkinson EK, Edwards JG ( 1978 ) . Non-reciprocal contact inhibition of locomotion of chick embryonic choroid fibroblasts by pigmented retina epithelial cells . Journal of Cell Science vol. 33 , ( 1 ) 103 - 120 .