Publications: Prof Vardhman Rakyan
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
(
2024
)
.
Author Correction: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
.
Genome Biology
vol.
25
,
(
1
)
Rodriguez-Algarra F, Evans DM, Rakyan VK
(
2024
)
.
Ribosomal DNA copy number variation associates with hematological profiles and renal function in the UK Biobank
.
Cell Genomics
vol.
4
,
(
6
)
Costeira R, Aduse-Opoku J, Vernon JJ, Rodriguez-Algarra F, Joseph S, Devine DA, Marsh PD, Rakyan V et al.
(
2023
)
.
Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis
.
mSystems
vol.
8
,
(
4
)
e01193
-
e01122
.
Holland ML, Rakyan VK
(
2022
)
.
A stochastic basis for metabolic phenotypes
.
Nature Metabolism
vol.
4
,
(
9
)
1091
-
1092
.
Rodriguez-Algarra F, Seaborne RAE, Danson AF, Yildizoglu S, Yoshikawa H, Law PP, Ahmad Z, Maudsley VA et al.
(
2022
)
.
Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states
.
Genome Biology
vol.
23
,
(
1
)
Ogunkolade BW, Adaikalakoteswari A, Cardoso SR, Lowe R, Patel N, Rakyan V, Finer S, Wabitsch M et al.
(
2022
)
.
An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes
.
Epigenetics
Marino S
(
2021
)
.
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma
.
Nature Communications
Åsenius F, Gorrie-Stone TJ, Brew A, Panchbhaya Y, Williamson E, Schalkwyk LC, Rakyan VK, Holland ML et al.
(
2020
)
.
The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations
.
PLOS Genetics
vol.
16
,
(
10
)
Lowe R, Danson AF, Rakyan VK, Yildizoglu S, Saldmann F, Viltard M, Friedlander G, Faulkes CG
(
2020
)
.
DNA methylation clocks as a predictor for ageing and age estimation in naked mole-rats, Heterocephalus glaber
.
Aging
vol.
12
,
Asenius F, Marzi SJ, Gorrie-Stone TJ, Brew A, Panchbaya Y, Williamson E, Schalkwyk L, Rakyan V et al.
(
2020
)
.
A lack of DNA methylation covariation between human blood and sperm make it unlikely to mediate intergenerational inheritance of acquired traits
.
HUMAN REPRODUCTION
.
vol.
35
,
112
-
112
.
Bell C, Lowe R, Adams P, Baccarelli A, Beck S, Bell J, Christensen B, Gladyshev V et al.
(
2019
)
.
DNA methylation aging clocks: challenges and recommendations
.
Genome Biology
Article
249 (2019)
,
Payne A, Holmes N, Rakyan V, Loose M
(
2018
)
.
BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files
.
Bioinformatics
vol.
35
,
(
13
)
2193
-
2198
.
DANSON AF, MARZI SJ, LOWE R, HOLLAND ML, RAKYAN V
(
2018
)
.
Early life diet conditions the molecular response to post-weaning protein restriction in the mouse
.
BMC Biology
vol.
16
,
(
51
)
LOWE R, BARTON C, Jenkins C, Ernst C, Forman O, Fernandez-Twinn D, Bock C, ROSSITER S et al.
(
2018
)
.
Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation amongst mammalian species
.
Genome Biology
vol.
19
,
Article
22
,
Thurner M, van de Bunt M, Torres JM, Mahajan A, Nylander V, Bennett AJ, Gaulton KJ, Barrett A et al.
(
2018
)
.
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
.
eLife
vol.
7
,
Brugha R, Lowe R, Henderson AJ, Holloway JW, Rakyan V, Wozniak E, Mahmud N, Seymour K et al.
(
2017
)
.
DNA methylation profiles between airway epithelium and proxy tissues in children
.
Acta Paediatrica
Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa J et al.
(
2017
)
.
Roadmap for investigating epigenome deregulation and environmental origins of cancer
.
International Journal of Cancer
vol.
142
,
(
5
)
874
-
882
.
Finer S, Lowe R, Ogunkolade W, Bhowmik B, Hussain A, Khan AKA, Rakyan V, Hitman GA
(
2017
)
.
The influence of maternal and offspring environment on genome-wide methylation of the offspring in Bangladesh
.
Manchester Central, Manchester
,
from:
08/03/2017
to:
10/03/2017
,
vol.
34
,
pp.
20
-
21
.
Abstract:
java.sql.Clob
org.hibernate.engine.jdbc.WrappedClob
java.io.Serializable
,
Paul DS, Teschendorff AE, Dang MAN, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S et al.
(
2016
)
.
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
.
Nat Commun
vol.
7
,
13555
-
13555
.
Breeze CE, Paul DS, van Dongen J, Butcher LM, Ambrose JC, Barrett JE, Lowe R, Rakyan VK et al.
(
2016
)
.
eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data
.
Cell Reports
vol.
17
,
(
8
)
2137
-
2150
.
Stunnenberg HG, Consortium TIHE, Abrignani S, Adams D, de Almeida M, Altucci L, Amin V, Amit I et al.
(
2016
)
.
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
.
Cell
vol.
167
,
(
5
)
1145
-
1149
.
Yang Z, Wong A, Kuh D, Paul DS, Rakyan VK, Leslie RD, Zheng SC, Widschwendter M et al.
(
2016
)
.
Correlation of an epigenetic mitotic clock with cancer risk
.
Genome Biology
vol.
17
,
(
1
)
Holland ML, Lowe R, Caton P, Gemma C, Carbajosa G, DANSON AF, Loche E, Carpenter AAM et al.
(
2016
)
.
Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice
.
Science
Paul DS, Jones A, Sellar RS, Mayor NP, Feber A, Webster AP, Afonso N, Sergeant R et al.
(
2015
)
.
A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
.
Genome Medicine
vol.
7
,
(
1
)
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al.
(
2015
)
.
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
.
Genome Biology
vol.
16
,
(
1
)
Kraiczy J, Nayak K, Ross A, Raine T, Mak TN, Gasparetto M, Cario E, Rakyan V et al.
(
2015
)
.
Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease
.
Mucosal Immunology
vol.
9
,
(
3
)
647
-
658
.
Lowe R, Gemma C, Rakyan VK, Holland ML
(
2015
)
.
Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development
.
BMC Genomics
vol.
16
,
(
1
)
Lowe R, Slodkowicz G, Goldman N, Rakyan VK
(
2015
)
.
The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues
.
Epigenetics
vol.
10
,
(
4
)
274
-
281
.
Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan VK, Hitman GA, Williams DJ
(
2015
)
.
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates
.
Epigenetics
vol.
10
,
(
1
)
50
-
61
.
Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D et al.
(
2015
)
.
Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring
.
Human molecular genetics
vol.
24
,
(
11
)
3021
-
3029
.
Lowe R, Rakyan VK
(
2014
)
.
Correcting for cell-type composition bias in epigenome-wide association studies
.
Genome Medicine
vol.
6
,
(
3
)
Mladkova N, Rakyan V, Proby C, Harwood C
(
2014
)
.
Genome-wide methylation profiling of cutaneous squamous cell carcinoma reveals novel epigenetically regulated genes and pathways
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
134
,
S6
-
S6
.
Hillman SL, Finer S, Smart MC, Rakyan V, Hitman GA, Williams DJ
(
2014
)
.
Identification of Novel DNA Methylation Profiles Associated with Gene Regulation and Metabolic Pathways in Growth Restricted Offspring
.
REPRODUCTIVE SCIENCES
vol.
21
,
(
3
)
166A
-
166A
.
Finer S, Mathews C, Smart M, Hillman S, Foo L, Lowe R, Rakyan V, Hitman G
(
2014
)
.
Maternal Gestational Diabetes Is Associated with Genome-Wide Methylation Variation in Placenta and Cord Blood of Exposed Offspring
.
DIABETES
.
vol.
63
,
A56
-
A56
.
Finer S, Iqbal S, Ogunkolade WB, Mathews C, Lowe R, Smart M, Rakyan VK, Alam DS et al.
(
2014
)
.
Variation in phenotype and DNA methylation is detectable in an observational cohort of young adult Bangladeshis exposed to famine during in utero and postnatal life
.
DIABETOLOGIA
vol.
57
,
S105
-
S106
.
Lowe R, Rakyan VK
(
2013
)
.
Marmal-aid--a database for Infinium HumanMethylation450
.
BMC Bioinformatics
vol.
14
,
Ke X, Cortina-Borja M, Silva BC, Lowe R, Rakyan V, Balding D
(
2013
)
.
Integrated analysis of genome-wide genetic and epigenetic association data for identification of disease mechanisms
.
Epigenetics
vol.
8
,
(
11
)
1236
-
1244
.
Ramagopalan SV, Rakyan VK
(
2013
)
.
The promise and challenges of blood spot methylomics
.
Epigenetics
vol.
8
,
(
8
)
775
-
777
.
Holland ML, Rakyan VK
(
2013
)
.
Transgenerational inheritance of non-genetically determined phenotypes
.
Biochemical Society Transactions
.
vol.
41
,
769
-
776
.
Holland ML, Rakyan VK
(
2013
)
.
Transgenerational inheritance of non-genetically determined phenotypes
.
Biochem Soc Trans
vol.
41
,
(
3
)
769
-
776
.
Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G et al.
(
2013
)
.
Inactive or moderately active human promoters are enriched for inter-individual epialleles
.
Genome Biol
vol.
14
,
(
5
)
Haesler R, Feng Z, Bäckdahl L, Spehlmann ME, Franke A, Teschendorff A, Rakyan V, Down TA et al.
(
2013
)
.
1032 Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study
.
Gastroenterology
vol.
144
,
(
5
)
s
-
193
.
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.
(
2013
)
.
Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies
.
Epigenetics : official journal of the DNA Methylation Society
vol.
8
,
(
4
)
445
-
454
.
Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.
(
2013
)
.
Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies
.
Epigenetics
vol.
8
,
(
4
)
445
-
454
.
Rakyan V
(
2013
)
.
A mouse model of non-genetic inter-generational effects
.
Endocrine Abstracts1
-
1
.
Brugha R, Lowe R, Henderson J, Holloway J, Rakyan V, Shaheen S
(
2013
)
.
Comparison of DNA methylation profiles between airway epithelium and proxy tissues
.
EUROPEAN RESPIRATORY JOURNAL
vol.
42
,
Haesler R, Feng Z, Baeckdahl L, Spehlmann ME, Franke A, Teschendorff A, Rakyan V, Down TA et al.
(
2013
)
.
Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study
.
GASTROENTEROLOGY
.
vol.
144
,
S193
-
S193
.
Bazeos A, Lowe R, Nteliopoulos G, Foroni L, Gerrard G, Goldman J, de Lavallade H, Rakyan V et al.
(
2013
)
.
THE CML EPIGENOME SHOWS DYNAMIC CHANGES IN THE CD34+COMPARTMENT IN PATIENTS WHO ACHIEVE COMPLETE CYTOGENETIC RESPONSE ON TYROSINE KINASE INHIBITORS
.
HAEMATOLOGICA
.
vol.
98
,
255
-
255
.
Häsler R, Feng Z, Bäckdahl L, Spehlmann ME, Franke A, Teschendorff A, Rakyan VK, Down TA et al.
(
2012
)
.
A functional methylome map of ulcerative colitis
.
Genome Res
vol.
22
,
(
11
)
2130
-
2137
.
Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G et al.
(
2012
)
.
Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans
.
Genome Res
vol.
22
,
(
11
)
2138
-
2145
.
Rakyan V
(
2012
)
.
The hunt for mammalian epialleles
.
BMC Proceedings
vol.
6
,
(
Suppl 6
)
Proudhon C, Duffié R, Ajjan S, Cowley M, Iranzo J, Carbajosa G, Saadeh H, Holland ML et al.
(
2012
)
.
Protection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametes
.
Mol Cell
vol.
47
,
(
6
)
909
-
920
.
GREENE NDE, COPP AJ, WARD A, LAKOWSKI J, HAN YT, PEARSON RA, GONZALEZ-CORDERO A, WEST EL et al.
(
2012
)
.
Abstracts of papers presented at the 22nd Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 17 November 2011
.
Genetics Research
vol.
94
,
(
1
)
49
-
55
.
Bazeos A, Lowe R, Apperley J, Marin D, Nteliopoulos G, de Lavallade H, Rezvani K, Bray E et al.
(
2012
)
.
A DNA METHYLATION CLASSIFIER PREDICTS RESPONSE TO IMATINIB IN PRE-TREATMENT CML SAMPLES
.
HAEMATOLOGICA
.
vol.
97
,
65
-
65
.
Saadeh H, Smallwood S, Proudhon C, Duffie R, Carbajosa G, Holland M, Rakyan V, Bourc'his D et al.
(
2012
)
.
A search for sequence-specific signals in maternally imprinted CGIs
.
GENETICS RESEARCH
.
vol.
94
,
355
-
355
.
Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B et al.
(
2012
)
.
BLUEPRINT to decode the epigenetic signature written in blood
.
NATURE BIOTECHNOLOGY
vol.
30
,
(
3
)
224
-
226
.
Saied MH, Marzec J, Khalid S, Smith P, Down TA, Rakyan VK, Molloy G, Raghavan M et al.
(
2012
)
.
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats
.
PLoS One
vol.
7
,
(
3
)
Mladkova N, McHugh A, Rakyan V, Proby C, Harwood C
(
2012
)
.
Methylation profiling of cutaneous squamous cell carcinoma reveals an embryonic stem cell signature among differentially methylated genes
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
166
,
e23
-
e23
.
Nanty L, Carbajosa G, Heap GA, Ratnieks F, van Heel DA, Down TA, Rakyan VK
(
2011
)
.
Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates
.
Genome Res
vol.
21
,
(
11
)
1841
-
1850
.
Mladkova N, McHugh A, Down T, Rakyan V, Proby C, Harwood C
(
2011
)
.
Identification of Differentially Methylated Genes in Cutaneous Squamous Cell Carcinoma from Epidermolysis Bullosa Patients and Normal Population
.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
.
vol.
131
,
S24
-
S24
.
Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al.
(
2011
)
.
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis
.
PLoS Genet
vol.
7
,
(
9
)
Rakyan VK, Down TA, Balding DJ, Beck S
(
2011
)
.
Epigenome-wide association studies for common human diseases
.
Nat Rev Genet
vol.
12
,
(
8
)
529
-
541
.
Mladkova N, McHugh A, Down T, Rakyan V, South A, Proby C, Harwood C
(
2011
)
.
Methylation profiling of cutaneous squamous cell carcinoma
.
BRITISH JOURNAL OF DERMATOLOGY
.
vol.
164
,
932
-
933
.
Feber A, Wilson GA, Zhang L, Presneau N, Idowu B, Down TA, Rakyan VK, Noon LA et al.
(
2011
)
.
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors
.
GENOME RESEARCH
vol.
21
,
(
4
)
515
-
524
.
Finer S, Holland ML, Nanty L, Rakyan VK
(
2011
)
.
The hunt for the epiallele
.
Environ Mol Mutagen
vol.
52
,
(
1
)
1
-
11
.
Thorne N, Marioni J, Rakyan V, Ibrahim A, Massie C, Curtis C, Brenton J, Murrell A et al.
(
2010
)
.
DNA Methylation Arrays
.
Microarray Innovations
,
vol.
20090856
,
Taylor & Francis
Bell CG, Teschendorff AE, Rakyan VK, Maxwell AP, Beck S, Savage DA
(
2010
)
.
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
.
BMC Med Genomics
vol.
3
,
Rakyan VK, Down TA, Maslau S, Andrew T, Yang T-P, Beyan H, Whittaker P, McCann OT et al.
(
2010
)
.
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
.
Genome Res
vol.
20
,
(
4
)
434
-
439
.
Novakovic B, Wong NC, Sibson M, Ng H-K, Morley R, Manuelpillai U, Down T, Rakyan VK et al.
(
2010
)
.
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta
.
J Biol Chem
vol.
285
,
(
13
)
9583
-
9593
.
Finer S, Holland M, Rakyan V, Hitman G
(
2010
)
.
A model of intrauterine hyperglycaemia provides evidence for fetal programming of glucose tolerance and a platform for epigenomic studies in mouse and human
.
Longitudinal and Life Course Studies: international journal
.
Conference:
The 5th Conference on Epidemiology and Longitudonal Studies in Europe
(
Paphos, Cyprus
)
from:
13/10/2010
to:
15/10/2010
,
vol.
1
,
Beyan H, Rakyan VK, Down TA, Hawa MI, Maslau S, Wallace C, Aden D, Mein CA et al.
(
2010
)
.
Identification of type 1 diabetes-associated methylation variable positions that precede disease diagnosis
.
DIABETOLOGIA
.
vol.
53
,
S145
-
S146
.
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendoff AE, Akan P, Stupka E et al.
(
2010
)
.
Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus
.
PLOS One
Beyan H, Rakyan VK, Down TA, Maslau S, Hawa MI, Boehm BO, Beck S, Leslie RD
(
2010
)
.
Whole-Genome Identification and Functional Analysis of Type 1 Diabetes-Associated Epigenetic Variation
.
DIABETES
.
vol.
59
,
A56
-
A56
.
Novakovic B, Sibson M, Ng HK, Manuelpillai U, Rakyan V, Down T, Beck S, Fournier T et al.
(
2009
)
.
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface
.
J Biol Chem
vol.
284
,
(
22
)
14838
-
14848
.
Papageorgiou EA, Fiegler H, Rakyan V, Beck S, Hulten M, Lamnissou K, Carter NP, Patsalis PC
(
2009
)
.
Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies
.
Am J Pathol
vol.
174
,
(
5
)
1609
-
1618
.
Thorne NP, Marioni JC, Rakyan VK, Ibrahim AEK, Massie CE, Curtis C, Brenton JD, Murrell A et al.
(
2009
)
.
DNA Methylation Arrays: Methods and Analysis
.
Microarray Innovations: Technology and Experimentation
,
Rakyan VK
(
2009
)
.
The Hunt for Epialleles
.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
.
vol.
50
,
543
-
543
.
Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou EM, Rakyan VK et al.
(
2008
)
.
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex
.
Genome Res
vol.
18
,
(
11
)
1778
-
1786
.
Rakyan VK, Down TA, Thorne NP, Flicek P, Kulesha E, Gräf S, Tomazou EM, Bäckdahl L et al.
(
2008
)
.
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
.
Genome Res
vol.
18
,
(
9
)
1518
-
1529
.
Novakovic B, Rakyan V, Ng HK, Manuelpillai U, Dewi C, Wong NC, Morley R, Down T et al.
(
2008
)
.
Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts
.
Mol Hum Reprod
vol.
14
,
(
9
)
547
-
554
.
Down TA, Rakyan VK, Turner DJ, Flicek P, Li H, Kulesha E, Gräf S, Johnson N et al.
(
2008
)
.
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
.
Nat Biotechnol
vol.
26
,
(
7
)
779
-
785
.
Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD et al.
(
2008
)
.
Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis
.
BMC Med Genomics
vol.
1
,
(
1
)
Beck S, Rakyan VK
(
2008
)
.
The methylome: approaches for global DNA methylation profiling
.
TRENDS IN GENETICS
vol.
24
,
(
5
)
231
-
237
.
Juran B, Lazaridis K
(
2007
)
.
Applying Genomics to the Study of Complex Disease
.
Seminars in Liver Disease
vol.
27
,
(
1
)
003
-
012
.
Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, Burger M, Burton J, Cox TV et al.
(
2006
)
.
DNA methylation profiling of human chromosomes 6, 20 and 22
.
Nat Genet
vol.
38
,
(
12
)
1378
-
1385
.
Rakyan VK, Beck S
(
2006
)
.
Epigenetic variation and inheritance in mammals
.
Curr Opin Genet Dev
vol.
16
,
(
6
)
573
-
577
.
Murrell A, Rakyan VK, Beck S
(
2005
)
.
From genome to epigenome
.
Hum Mol Genet
vol.
14 Spec No 1
,
R3
-
R10
.
RAKYAN V, Novik KL, Hildmann T, Lewin J
(
2004
)
.
DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project
.
PLoS Biol
vol.
2
,
(
12
)
e405
-
e405
.
Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KVK, Whitelaw E
(
2003
)
.
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission
.
Proc Natl Acad Sci U S A
vol.
100
,
(
5
)
2538
-
2543
.
Rakyan V, Whitelaw E
(
2003
)
.
Transgenerational epigenetic inheritance
.
Curr Biol
vol.
13
,
(
1
)
Rakyan VK, Blewitt ME, Druker R, Preis JI, Whitelaw E
(
2002
)
.
Metastable epialleles in mammals
.
Trends Genet
vol.
18
,
(
7
)
348
-
351
.
Rakyan VK, Preis J, Morgan HD, Whitelaw E
(
2001
)
.
The marks, mechanisms and memory of epigenetic states in mammals
.
Biochem J
vol.
356
,
(
Pt 1
)
1
-
10
.
RAKYAN VK, PREIS J, MORGAN HD, WHITELAW E
(
2001
)
.
The marks, mechanisms and memory of epigenetic states in mammals
.
Biochemical Journal
vol.
356
,
(
1
)
1
-
10
.
Morgan H, Preis J, Rakyan V, Whitelaw E
(
2001
)
.
Inheritance: Not only DNA
.
Today's Life Science
vol.
13
,
(
1
)
32
-
36
.
Van Der Weyden L, Rakyan V, Luttrell BM, Morris MB, Conigrave AD
(
2000
)
.
Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells
.
Immunology and Cell Biology
vol.
78
,
(
5
)
467
-
473
.