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Research

Publications: Prof Patricia Munroe

Jepson RE, Warren H, Wallace MD, Syme HM, Elliott J, Munroe PB ( 2022 ) . First genome-wide association study investigating blood pressure and renal traits in domestic cats . Scientific Reports vol. 12 , ( 1 )
Young WJ, Lahrouchi N, Isaacs A, Duong TV, Foco L, Ahmed F, Brody JA, Salman R et al. ( 2022 ) . Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways . Nature Communications vol. 13 , ( 1 )
Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples . Translational Psychiatry vol. 12 , ( 1 )
Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Trubetskoy V, Pluess M ( 2022 ) . Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation . Journal of Child Psychology and Psychiatry and Allied Disciplines vol. 63 , ( 10 ) 1140 - 1152 .
Ramírez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2022 ) . Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors . Circulation: Genomic and Precision Medicine vol. 15 , ( 5 ) 444 - 452 .
Petersen S, Raisi Estabragh Z, Munroe P ( 2022 ) . Incident clinical and mortality associations of myocardial native T1 in the UK Biobank: A prospective observational study . JACC: Cardiovascular Imaging
Ramírez J, Kiviniemi A, van Duijvenboden S, Tinker A, Lambiase PD, Junttila J, Perkiömäki JS, Huikuri HV et al. ( 2022 ) . ECG T-Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low-and Moderate-Risk Populations . Journal of the American Heart Association vol. 11 , ( 17 )
Raisi-Estabragh Z, Mccracken C, Condurache DG, Aung N, Vargas JD, Naderi H, Munroe PB, Neubauer S et al. ( 2022 ) . Erratum: Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study (European Heart Journal - Cardiovascular Imaging (2022) (jeab266) DOI: 10.1093/ehjci/jeab266) . European Heart Journal Cardiovascular Imaging vol. 23 , ( 9 )
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al. ( 2022 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids . American Journal of Human Genetics vol. 109 , ( 8 ) 1366 - 1387 .
Kelly TN, Sun X, He KY, Brown MR, Taliun SAG, Hellwege JN, Irvin MR, Mi X et al. ( 2022 ) . Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension . Hypertension vol. 79 , ( 8 ) 1656 - 1667 .
Ramírez J, Van Duijvenboden S, Young W, Tinker A, Lambiase P, Orini M, Munroe P ( 2022 ) . Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors . Atherosclerosis vol. 355 , 3 - 4 .
Shah RA, Asatryan B, Sharaf Dabbagh G, Aung N, Khanji MY, Lopes LR, Van Duijvenboden S, Holmes A et al. ( 2022 ) . Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy-Associated Putative Pathogenic Gene Variants in UK Biobank Participants . Circulation vol. 146 , ( 2 ) 110 - 124 .
Machlitt-Northen S, Keers R, Munroe PB, Howard DM, Pluess M ( 2022 ) . Gene–Environment Correlation over Time: A Longitudinal Analysis of Polygenic Risk Scores for Schizophrenia and Major Depression in Three British Cohorts Studies . Genes vol. 13 , ( 7 )
Petersen S, Aung N, Munroe P ( 2022 ) . Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function . Nature Genetics
Naderi H, Ramírez J, Van Duijvenboden S, Aung N, Fung K, Young W, Petersen S, Munroe P ( 2022 ) . PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK . Journal of hypertension . vol. 40 ,
Shah R, Asatryan B, Dabbagh GS, Khanji M, van Duijvenboden S, Muser D, Landstrom AP, Semsarian C et al. ( 2022 ) . EN-571-02 SCREENING FOR PUTATIVE PATHOGENIC VARIANTS IN DILATED CARDIOMYOPATHY GENES IDENTIFIES EARLY DISEASE AND PREDICTS MORTALITY . Heart Rhythm vol. 19 , ( 5 ) s101 - s102 .
Calabrese C, Pyle A, Griffin H, Coxhead J, Hussain R, Braund PS, Li L, Burgess A et al. ( 2022 ) . Heteroplasmic mitochondrial DNA variants in cardiovascular diseases . PLoS Genetics vol. 18 , ( 4 )
Warren H, Edwards T, Vaez A, Keaton J, Kamali Z, Xie T, Ani A, Evangelou E et al. ( 2022 ) . Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure .
Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M ( 2022 ) . Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study . Neurology vol. 98 , ( 4 ) E343 - E351 .
Petersen S, Aung N, Khanji M, Fung K, Raisi-Estabragh Z, Munroe P ( 2022 ) . Light to moderate coffee consumption is associated with lower risk of death: a UK Biobank study . European Journal of Preventive Cardiology
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen A et al. ( 2022 ) . A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries .
Trompet S, Postmus I, Warren HR, Noordam R, Smit RAJ, Theusch E, Li X, Arsenault B et al. ( 2022 ) . The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction . Frontiers in Pharmacology vol. 12 ,
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al. ( 2022 ) . A saturated map of common genetic variants associated with human height . Nature
Raisi-Estabragh Z, Harvey NC, Munroe P ( 2021 ) . Novel determinants of Cardiovascular disease: a population approach .
Graham SE, Clarke SL, Wu KHH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al. ( 2021 ) . The power of genetic diversity in genome-wide association studies of lipids . Nature vol. 600 , ( 7890 ) 675 - 679 .
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke S, Bhatti KF et al. ( 2021 ) . Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis .
Van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB ( 2021 ) . Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders . Human Molecular Genetics vol. 30 , ( 24 ) 2513 - 2523 .
Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study . European Heart Journal: Cardiovascular Imaging
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke S et al. ( 2021 ) . A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids .
Raisi-Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva J, Sanghvi M, Thomson R et al. ( 2021 ) . ASSOCIATIONS BETWEEN BONE AND VASCULAR HEALTH IN THE UK BIOBANK . OSTEOPOROSIS INTERNATIONAL . vol. 32 , S41 - S41 .
Olczak KJ, Taylor-Bateman V, Nicholls HL, Traylor M, Cabrera CP, Munroe PB ( 2021 ) . Hypertension genetics past, present and future applications . Journal of Internal Medicine vol. 290 , ( 6 ) 1130 - 1152 .
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9) . Nature Communications vol. 12 , ( 1 )
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al. ( 2021 ) . Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability . Nature Communications vol. 12 , ( 1 )
Young W, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Brody J, Salman R et al. ( 2021 ) . Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization .
Fung K, Biasiolli L, Hann E, Lukaschuk E, Ramírez J, van Duijvenboden S, Aung N, Paiva JM et al. ( 2021 ) . 9 Identification of thirty novel loci for cardiovascular magnetic resonance derived aortic distensibility in the UK Biobank . Heart . Conference: BSCMR 2021 vol. 107 , a6 - a8 .
Moksnes MR, Røsjø H, Richmond A, Lyngbakken MN, Graham SE, Hansen AF, Wolford BN, Gagliano Taliun SA et al. ( 2021 ) . Genome-wide association study of cardiac troponin i in the general population . Human Molecular Genetics vol. 30 , ( 21 ) 2027 - 2039 .
Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, Sung YJ, Bentley AR et al. ( 2021 ) . Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure . Molecular Psychiatry vol. 26 , ( 11 ) 6293 - 6304 .
Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Kolossvary M, Merkely B, Munroe PB et al. ( 2021 ) . Association of daily coffee consumption with cardiovascular health – results from the UK Biobank . European Heart Journal vol. 42 , ( Supplement_1 )
Ramirez J, van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Orini M, Munroe PB ( 2021 ) . Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors . GENETIC EPIDEMIOLOGY . vol. 45 , 783 - 783 .
McDonough CW, Warren HR, Jack JR, Motsinger-Reif AA, Armstrong ND, Bis JC, House JS, Singh S et al. ( 2021 ) . Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies . Clinical Pharmacology and Therapeutics vol. 110 , ( 3 ) 723 - 732 .
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )
Young W, Isaacs A, Lahrouchi N, Mifsud B, Munroe PB, Newton-Cheh CH, Sotoodehnia N, group OTCEW ( 2021 ) . B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL . Heart Rhythm vol. 18 , ( 8 )
Petersen S, Munroe P, Pugliese F, Lee A, Raisi-Estabragh Z ( 2021 ) . Automated quality-controlled cardiovascular magnetic resonance pericardial fat quantification using a convolutional neural network in the UK Biobank . Frontiers in Cardiovascular Medicine
Raisi-Estabragh Z, Martineau A, Curtis E, Moon R, Darling A, Lanham-New S, Ward K, Cooper C et al. ( 2021 ) . Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review . Aging Clinical and Experimental Research
van Duijvenboden S, Ramirez J, Orini M, Tinker A, Munroe P, Lambiase P ( 2021 ) . 85 Prognostic value of premature ventricular complexes during exercise stress testing in 56,000 individuals without known structural heart disease from UK biobank: is a single ectopic prognostic? . Heart . Conference: Cardiac rhythm management vol. 107 , a68 - a68 .
Young W, Warren H, Mook-Kanamori D, Ramirez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D et al. ( 2021 ) . BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study . Heart . Conference: Basic science vol. 107 , a159 - a160 .
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, Van Duijvenboden S, Orini M, Tinker A, Van Heemst D et al. ( 2021 ) . Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank . Circulation: Genomic and Precision Medicine vol. 14 , ( 3 )
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al. ( 2021 ) . The trans-ancestral genomic architecture of glycemic traits . Nature Genetics vol. 53 , ( 6 ) 840 - 860 .
Manandhar I, Alimadadi A, Aryal S, Munroe P, Joe B, Cheng X ( 2021 ) . Machine Learning of Gut Microbiome Composition for Diagnostic Classification of Inflammatory Bowel Diseases . The FASEB Journal vol. 35 , ( S1 )
Raisi-Estabragh Z, Mccracken C, Gkontra P, Jaggi A, Ardissino M, Cooper J, Biasiolli L, Aung N et al. ( 2021 ) . Higher consumption of red and processed meat is associated with adverse cardiovascular magnetic resonance morpho-functional phenotypes: A study of 19,408 UK Biobank participants . European Journal of Preventive Cardiology . vol. 28 ,
Petersen S, Munroe P, Aung N, Raisi-Estabragh Z ( 2021 ) . Associations of Meat and Fish Consumption With Conventional and Radiomics Cardiovascular Magnetic Resonance Phenotypes in the UK Biobank . Frontiers of Cardiovascular Medicine
Rezaei MJ, Woodward JR, Ramírez J, Munroe P ( 2021 ) . A novel two-stage heart arrhythmia ensemble classifier . Computers vol. 10 , ( 5 )
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2021 ) . Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x) . Nature Genetics vol. 53 , ( 5 )
Raisi-Estabragh Z, Kenawy AAM, Aung N, Cooper J, Munroe PB, Harvey NC, Petersen SE, Khanji MY ( 2021 ) . Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis . European Heart Journal Cardiovascular Imaging vol. 22 , ( 5 ) 494 - 504 .
Petersen S, Munroe P, Aung N ( 2021 ) . Prevalence of hypertrophic cardiomyopathy in the UK Biobank population . JAMA Cardiology
Petersen S ( 2021 ) . Women with diabetes are at increased relative risk of heart failure compared to men: Insights from UK Biobank . Frontiers in Cardiovascular Medicine
Warren H, Garofalidou T, Singh S, Melander O, Hiltunen T, Glorioso N, Cooper-Dehoff R, Dominiczak A et al. ( 2021 ) . GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS . Journal of Hypertension vol. 39 , ( Supplement 1 ) e258 - e259 .
Warren H, Traylor M, Garofalidou T, Ng FL, Gupta A, Sever P, Caulfield M, Munroe P ( 2021 ) . HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT . Journal of Hypertension vol. 39 , ( Supplement 1 )
Raisi-Estabragh Z, McCracken C, Cooper J, Fung K, Paiva J, Khanji M, Rauseo E, Biasiolli L et al. ( 2021 ) . Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: Findings from the UK Biobank . Aging Clinical and Experimental Research
Mensah-Kane J, Schmidt AF, Hingorani AD, Finan C, Chen Y, van Duijvenboden S, Orini M, Lambiase PD et al. ( 2021 ) . No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis . Frontiers in Genetics vol. 12 ,
Magavern EF, Warren HR, Ng FL, Cabrera CP, Munroe PB, Caulfield MJ ( 2021 ) . An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX . Hypertension vol. 77 , ( 2 ) 284 - 295 .
Manandhar I, Alimadadi A, Aryal S, Munroe PB, Joe B, Cheng X ( 2021 ) . Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases . Am J Physiol Gastrointest Liver Physiol
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Jones AR, Lambiase PD, Munroe PB, Tinker A ( 2021 ) . Analysing electrocardiographic traits and predicting cardiac risk in UK biobank . JRSM Cardiovasc Dis vol. 10 ,
Raisi-Estabragh Z, Jaggi A, Gkontra P, McCracken C, Aung N, Munroe PB, Neubauer S, Harvey NC et al. ( 2021 ) . Cardiac Magnetic Resonance Radiomics Reveal Differential Impact of Sex, Age, and Vascular Risk Factors on Cardiac Structure and Myocardial Tissue . Front Cardiovasc Med vol. 8 ,
Rezaei MJ, Woodward JR, Ramirez J, Munroe P ( 2021 ) . Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia . Proceedings of the International Conference on Biomedical Innovations and Applications, BIA 2021 . 45 - 50 .
Cartwright JH, Aziz Q, Harmer SC, Thayyil S, Tinker A, Munroe PB ( 2021 ) . Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function . Human Molecular Genetics vol. 29 , ( 5 ) 1797 - 1807 .
Raisi-Estabragh Z, Biasiolli L, Cooper J, Aung N, Fung K, Paiva JM, Sanghvi MM, Thomson RJ et al. ( 2021 ) . Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank . Journal of Bone and Mineral Research vol. 36 , ( 1 ) 90 - 99 .
Sebastian S, Nobles M, Tsisanova E, Ludwig A, Munroe PB, Tinker A ( 2021 ) . The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate . Physiological Genomics vol. 53 , ( 4 ) 150 - 159 .
Petersen S, Raisi-Estabragh Z ( 2020 ) . REPEATABILITY OF CARDIAC MAGNETIC RESONANCE RADIOMICS: A MULTICENTRE MULTI-VENDOR TEST-RETEST STUDY . Frontiers in Cardiovascular Medicine
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al. ( 2020 ) . Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals . Nature Genetics vol. 52 , ( 12 ) 1314 - 1332 .
Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD et al. ( 2020 ) . Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction . Nature Communications vol. 11 , ( 1 )
Cabrera CP, Pazoki R, Giri A, Hellwege JN, Evangelou E, Ramirez J, Wain LV, Tzoulaki I et al. ( 2020 ) . Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 28 , 105 - 105 .
Aung N, Sanghvi M, Piechnik SK, Naubauer S, Munroe P, Petersen S ( 2020 ) . The effect of lipids on the left ventricle: a Mendelian randomization study . JACC - Journal of the American College of Cardiology vol. 76 , ( 21 )
Aung N, Khanji MY, Munroe PB, Petersen SE ( 2020 ) . Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study . Frontiers in Genetics vol. 11 ,
Young WJ, van Duijvenboden S, Ramírez J, Jones A, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs . Biomedical Signal Processing and Control vol. 64 ,
Rezaei MJ, Woodward JR, Ramirez J, Munroe P ( 2020 ) . Data Augmentation for Heart Arrhythmia Classification . Proceedings - International Conference on Tools with Artificial Intelligence, ICTAI . vol. 2020-November , 929 - 934 .
Raisi-Estabragh Z, Jaggi A, Aung N, Neubauer S, Piechnik S, Munroe PB, Harvey NC, Lekadir K et al. ( 2020 ) . Variation of cardiac magnetic resonance radiomics features by age and sex in healthy participants from the UK Biobank . European Heart Journal . vol. 41 ,
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al. ( 2020 ) . Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci . Molecular Psychiatry vol. 25 , ( 10 ) 2392 - 2409 .
García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2020 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank . Translational Psychiatry vol. 10 , ( 1 )
Young WJ, Srinivasan N, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Comparisons of the Spatial QRS-T Angle with Intra-cardiac Markers of Depolarization and Repolarization . Computing in Cardiology . vol. 2020-September ,
Van Duijvenboden S, Ramirez J, Young WJ, Tinker A, Munroe PB, Lambiase PD, Orini M ( 2020 ) . Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate . Computing in Cardiology . vol. 2020-September ,
Aung N, Young WJ, Van Duijvenboden S, Ramirez J, Petersen SE, Munroe PB ( 2020 ) . Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes . Computing in Cardiology . vol. 2020-September ,
Ramirez J, Van Duijvenboden S, Young WJ, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Interaction between ECG and Genetic Markers of Coronary Artery Disease . Computing in Cardiology . Conference: CinC 2020 from: 13/09/2020 to: 16/09/2020 , vol. 2020-September ,
Ramirez J, Van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Sex Differences in the Morphology of RR-Matched T-waves . Computing in Cardiology . vol. 2020-September ,
Young WJ, Ramirez J, Van Duijvenboden S, Tinker A, Lambiase PD, Munroe PB, Orini M ( 2020 ) . Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice? . Computing in Cardiology . vol. 2020-September ,
Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B, Cheng X ( 2020 ) . Machine learning-based classification and diagnosis of clinical cardiomyopathies . Physiol Genomics vol. 52 , ( 9 ) 391 - 400 .
Patel V, Asatryan B, Siripanthong B, Munroe PB, Tiku-Owens A, Lopes LR, Khanji MY, Protonotarios A et al. ( 2020 ) . State of the art review on genetics and precision medicine in arrhythmogenic cardiomyopathy . International Journal of Molecular Sciences vol. 21 , ( 18 ) 1 - 47 .
Cheng X, Alimadadi A, Manandhar I, Aryal S, Munroe PB, Joe B ( 2020 ) . Abstract P051: Application Of Artificial Intelligence In Transcriptome-based Diagnosis Of Cardiomyopathies . Hypertension vol. 76 , ( Suppl_1 )
Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC et al. ( 2020 ) . Greater risk of severe COVID-19 in black, asian and minority ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: Study of 1326 cases from the UK biobank . Journal of Public Health (United Kingdom) vol. 42 , ( 3 ) 451 - 460 .
Weng LC, Hall AW, Choi SH, Jurgens SJ, Haessler J, Bihlmeyer NA, Grarup N, Lin H et al. ( 2020 ) . Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation . Circulation: Genomic and Precision Medicine389 - 395 .
Van Duijvenboden S, Ramírez J, Young WJ, Mifsud B, Orini M, Tinker A, Munroe PB, Lambiase PD ( 2020 ) . Genetic Basis and Prognostic Value of Exercise QT Dynamics . Circulation: Genomic and Precision Medicine vol. 13 , ( 4 )
Ramírez J, van Duijvenboden S, Young WJ, Orini M, Lambiase PD, Munroe PB, Tinker A ( 2020 ) . Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval . American Journal of Human Genetics vol. 106 , ( 6 ) 764 - 778 .
Raisi-Estabragh Z, McCracken C, Bethell M, Cooper J, Cooper C, Caulfield M, Munroe P, Harvey N et al. ( 2020 ) . Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank .
Wang H, Noordam R, Cade B, Schwander K, Winkler T, Lee J, Sung YJ, Bentley A et al. ( 2020 ) . Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure .
Raisi-Estabragh Z, Cooper J, Judge R, Khanji M, Munroe P, Cooper C, Harvey NC, Petersen S ( 2020 ) . Age, sex and disease-specific associations between resting heart rate and cardiovascular mortality in the UK BIOBANK . PLoS One
de las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR et al. ( 2020 ) . Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci . Molecular Psychiatry
Nicholls HL, John CR, Watson DS, Munroe PB, Barnes MR, Cabrera CP ( 2020 ) . Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci . Frontiers in Genetics vol. 11 ,
Alimadadi A, Aryal S, Manandhar I, Munroe PB, Joe B, Cheng X ( 2020 ) . Artificial intelligence and machine learning to fight covid-19 . Physiological Genomics vol. 52 , ( 4 ) 200 - 202 .
Alimadadi A, Munroe PB, Joe B, Cheng X ( 2020 ) . Meta-analysis of dilated cardiomyopathy using cardiac rna-seq transcriptomic datasets . Genes vol. 11 , ( 1 )
Fung K, Biasiolli L, Hann E, Ramirez J, Lukaschuk E, Aung N, Paiva J, Werys K et al. ( 2020 ) . 3.2 First Genome-Wide Association Study of Cardiovascular Magnetic Resonance Derived Aortic Distensibility Reveals 7 Loci . Artery Research . vol. 25 ,
Aung N, Doimo S, Ricci F, Sanghvi MM, Pedrosa C, Woodbridge SP, Al-Balah A, Zemrak F et al. ( 2020 ) . Prognostic significance of left ventricular noncompaction: Systematic review and meta-analysis of observational studies . Circulation: Cardiovascular Imaging
García-González J, Ramírez J, Howard D, Brennan C, Munroe P, Keers R ( 2019 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank .
Fung K, Ramírez J, Warren HR, Aung N, Lee AM, Tzanis E, Petersen SE, Munroe PB ( 2019 ) . Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants . Scientific Reports vol. 9 , ( 1 )
Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, de Vries PS, Sung YJ et al. ( 2019 ) . Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration . Nature Communications vol. 10 , ( 1 )
Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI et al. ( 2019 ) . Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity . Nature Communications vol. 10 , ( 1 )
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al. ( 2019 ) . Associations of autozygosity with a broad range of human phenotypes . Nature Communications vol. 10 , ( 1 ) 4957 - 4957 .
Munroe PB, Ramírez J, van Duijvenboden S ( 2019 ) . Resting Heart Rate and Type 2 Diabetes: A Complex Relationship in Need of Greater Understanding . Journal of the American College of Cardiology vol. 74 , ( 17 ) 2175 - 2177 .
Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, Nelson CP, Bastiaenen R et al. ( 2019 ) . KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern . JCI insight
Ng N, Willems S, Fernandez J, Fine R, Wheeler E, Wessel J, Kitajima H, Marenne G et al. ( 2019 ) . Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation .
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Escamilla MA, Batki S, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T et al. ( 2002 ) . Comorbidity of bipolar disorder and substance abuse in Costa Rica: Pedigree- and population-based studies . Journal of Affective Disorders vol. 71 , ( 1-3 ) 71 - 83 .
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Couto E, Harrison DAH, Duffy SW, Myles J, Sala E, Warren RML, Day NE, Luben R et al. ( 2001 ) . Estimation of disease progression parameters from case-control data: Application to mammographic patterns and breast cancer natural history . Journal of Epidemiology and Biostatistics vol. 6 , ( 2 ) 235 - 242 .
Titan SMO, Bingham S, Welch A, Luben R, Oakes S, Day N, Khaw KT ( 2001 ) . Frequency of eating and concentrations of serum cholesterol in the Norfolk population of the European prospective investigation into cancer (EPIC-Norfolk): Cross sectional study . British Medical Journal vol. 323 , ( 7324 ) 1286 - 1288 .
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Faham M, Baharloo S, Tomitaka S, Deyoung J, Freimer NB ( 2001 ) . Mismatch repair detection (MRD): High-throughput scanning for DNA variations . Human Molecular Genetics vol. 10 , ( 16 ) 1657 - 1664 .
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Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Identification of a transactivation motif in the CLN3 protein . IUBMB Life vol. 51 , ( 5 ) 295 - 298 .
Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB ( 2001 ) . Screening a large reference sample to identify very low frequency sequence variants: Comparisons between two genes . Nature Genetics vol. 27 , ( 4 ) 435 - 438 .
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Leung KY, Greene ND, Munroe PB, Mole SE ( 2001 ) . Analysis of CLN3-protein interactions using the yeast two-hybrid system . Eur J Paediatr Neurol vol. 5 Suppl A , 89 - 93 .
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Mathews CA, Herrera Amighetti LD, Lowe TL, Van De Wetering BJM, Freimer NB, Reus VI ( 2001 ) . Cultural influences on diagnosis and perception of Tourette syndrome in Costa Rica . Journal of the American Academy of Child and Adolescent Psychiatry vol. 40 , ( 4 ) 456 - 463 .
Welch AA, McTaggart A, Mulligan AA, Luben R, Walker N, Khaw KT, Day NE, Bingham SA ( 2001 ) . DINER (Data Into Nutrients for Epidemiological Research) - A new data-entry program for nutritional analysis in the EPIC-Norfolk cohort and the 7-day diary method . Public Health Nutrition vol. 4 , ( 6 ) 1253 - 1265 .
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Ophoff RA, De Young J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J et al. ( 2001 ) . Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3 . American Journal of Human Genetics vol. 69 , ( 2 ) 447 - 453 .
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Crouau-Roy B, Service S, Slatkin M, Freimer N ( 1996 ) . A fine-scale comparison of the human and chimpanzee genomes: Linkage, linkage disequilibrium and sequence analysis . Human Molecular Genetics vol. 5 , ( 8 ) 1131 - 1137 .
Di Rienzo A, Peterson AC, Freimer NB ( 1996 ) . Amplification with arbitrary primers . Methods in molecular biology (Clifton, N.J.) vol. 54 , 123 - 129 .
Smith LB, Sapers B, Reus VI, Freimer NB ( 1996 ) . Attitudes towards bipolar disorder and predictive genetic testing among patients and providers . Journal of Medical Genetics vol. 33 , ( 7 ) 544 - 549 .
Knisely AS, Kocoshis S, O'Connell N, Setchell KD, Bull LN, Freimer NB ( 1996 ) . Deficiency of chenodeoxycholic acid in bile: Byler disease and byler syndrome . Journal of Pediatric Gastroenterology and Nutrition vol. 23 , ( 3 )
Garza JC, Freimer NB ( 1996 ) . Homoplasy for size at microsatellite loci in humans and chimpanzees . Genome Research vol. 6 , ( 3 ) 211 - 217 .
Sela-Herman S, Bull L, Lomri N, Rahmaoui C, Luther T, Hammerman P, Genant J, Freimer N et al. ( 1996 ) . In search of a gene for hereditary cholestasis . Biochemical and Molecular Medicine vol. 59 , ( 2 ) 98 - 103 .
Houwen RHJ, Sinke R, Juyn J, Freimer N, Berger R ( 1996 ) . Mapping of the gene for bric and byler disease . Journal of Pediatric Gastroenterology and Nutrition vol. 22 , ( 4 )
Freimer NB, Blower S, Slatkin M ( 1996 ) . Pathogens &amp; strain diversity: Is sex disruptive? . Nature Medicine vol. 2 , ( 4 ) 401 - 403 .
Järvelä I, Mitchison HM, Munroe PB, O'Rawe AM, Mole SE, Syvänen AC ( 1996 ) . Rapid diagnostic test for the major mutation underlying Batten disease . Journal of Medical Genetics vol. 33 , ( 12 ) 1041 - 1042 .
Carlton VEH, Knisely AS, Freimer NB ( 1995 ) . Mapping of a locus for progressive familial intrahepatic cholestasis (byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region . Human Molecular Genetics vol. 4 , ( 6 ) 1049 - 1053 .
Peterson AC, Di Rienzo A, Lehesjokl AE, De La Chaelle A, Slatkin M, Frelmer NB ( 1995 ) . The distribution of linkage disequilibrium over anonymous genome regions . Human Molecular Genetics vol. 4 , ( 5 ) 887 - 894 .
Munroe PB, Daniel HI, Farrall M, Lawson M, Bouloux PM, Caulfield MJ ( 1995 ) . Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension . Journal of Human Hypertension . vol. 9 , 669 - 670 .
Munroe PB, Mitchison HM, Dooley TP, Gardiner RM, Mole SE ( 1995 ) . Analysis of Batten disease candidate genes STP and STM . American Journal of Medical Genetics . vol. 57 , 324 - 326 .
McInnes LA, Freimer NB ( 1995 ) . Mapping genes for psychiatric disorders and behavioral traits . Current Opinion in Genetics and Development vol. 5 , ( 3 ) 376 - 381 .
Garza JC, Slatkin M, Freimer NB ( 1995 ) . Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size . Molecular Biology and Evolution vol. 12 , ( 4 ) 594 - 603 .
JäRvelä IE, Mitchison HM, O’Rawe AM, Munroe PB, Taschner PEM, Devos N, Lerner TJ, D’Arigo KL et al. ( 1995 ) . YAC and cosmid contigs spanning the batten disease (CLN3) region at 16p12.1-p11.2 . Genomics vol. 29 , ( 2 ) 478 - 489 .
Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark AJL ( 1994 ) . Linkage of the angiotensinogen gene to essential hypertension . New England Journal of Medicine vol. 330 , ( 23 ) 1629 - 1633 .
Di Rienzo A, Peterson AC, Garza JC, Valdes AM, Slatkin M, Freimer NB ( 1994 ) . Mutational processes of simple-sequence repeat loci in human populations . Proceedings of the National Academy of Sciences of the United States of America vol. 91 , ( 8 ) 3166 - 3170 .
Kamdar S, Daniel H, Fogarty P, Lawson M, Munroe P, Caulfield M ( 1994 ) . ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension . Journal of Human Hypertension . vol. 8 ,
Houwen RHJ, Baharloo S, Blankenship K, Raeymaekers P, Juyn J, Sandkuijl LA, Freimer NB ( 1994 ) . Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis . Nature Genetics vol. 8 , ( 4 ) 380 - 386 .
Dooley TP, Probst P, Munroe PB, Mole SE, Liu Z, Doggett NA ( 1994 ) . Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene (STM) . Biochemical and Biophysical Research Communications vol. 205 , ( 2 ) 1325 - 1332 .
Munroe PB, Johnston A, Duke VM, Daniel HI, Bouloux PM, Lawson M, Caulfield MJ ( 1994 ) . Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension . Journal of Human Hypertension . vol. 8 , 613 - 614 .
Daniel HI, Munroe PB, Lawson M, Fogarty P, Kamdar SM, Caulfield MJ ( 1994 ) . Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans . Journal of Human Hypertension . vol. 8 , 609 - 610 .
Dooley TP, Mitchison HM, Munroe PB, Probst P, Neal M, Siciliano MJ, Deng ZM, Doggett NA et al. ( 1994 ) . Mapping of Two Phenol Sulfotransferase Genes, STP and STM, to 16p: Candidate Genes for Batten Disease . Biochemical and Biophysical Research Communications vol. 205 , ( 1 ) 482 - 489 .
Di Rienzo A, Peterson A, Das S, Freimer NB ( 1993 ) . Genome mapping by arbitrary amplification of yeast artificial chromosomes . Mammalian Genome vol. 4 , ( 7 ) 359 - 363 .
Valdes AM, Slatkin M, Freimer NB ( 1993 ) . Allele frequencies at microsatellite loci: The stepwise mutation model revisited . Genetics vol. 133 , ( 3 ) 737 - 749 .
Munroe PB, Caulfield M, Daniel H, Lawson M, Bouloux PMG, Turner P ( 1993 ) . Analysis of the insulin receptor RsaI polymorphism in essential hypertension . British Journal of Clinical Pharmacology . vol. 35 ,
Bouloux PG, Kirk J, Munroe P, Duke V, Meindl A, Hilson A, Grant D, Carter N et al. ( 1993 ) . Deletion analysis maps ocular albinism proximal to the steroid sulphatase locus . Clinical Genetics vol. 43 , ( 4 ) 169 - 173 .
Freimer NB, Sandkuijl LA, Blower SM ( 1993 ) . Incorrect specification of marker allele frequencies: Effects on linkage analysis . American Journal of Human Genetics vol. 52 , ( 6 ) 1102 - 1110 .
Scanlon TJ, Luben RN, Scanlon FL, Singleton N ( 1993 ) . Is Friday the 13th bad for your health? . British Medical Journal vol. 307 , ( 6919 ) 1584 - 1586 .
Consalez GG, Stayton CL, Freimer NB, Goonewardena P, Brown WT, Gilliam TC, Warren ST ( 1992 ) . Isolation and characterization of a highly polymorphic human locus (DXS455) in proximal Xq28 . Genomics vol. 12 , ( 4 ) 710 - 714 .
Bouloux PMG, Munroe P, Kirk J, Besser GM ( 1992 ) . Sex and smell - An enigma resolved . Journal of Endocrinology vol. 133 , ( 3 ) 323 - 326 .
Bouloux PMG, Hardelin JP, Munroe P, Kirk JMW, Legouis R, Levilliers J, Hazan J, Weissenbach J et al. ( 1991 ) . A dinucleotide repeat polymorphism at the kallmann locus (Xp22.3) . Nucleic Acids Research vol. 19 , ( 19 )
Kleyn PW, Brzustowicz LM, Wilhelmsen KA, Freimer NB, Miller JM, Munsat TL, Gilliam TC ( 1991 ) . Spinal muscular atrophy is not the result of mutations at the beta–hexosaminidase or GM<inf>2</inf>–activator locus . Neurology vol. 41 , ( 9 ) 1418 - 1422 .
Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ ( 1989 ) . Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia . Genomics vol. 5 , ( 4 ) 940 - 944 .
Freimer N, Lu F, Chen J ( 1989 ) . Posttraumatic stress and conversion disorders in a Laotian Refugee veteran: Use of Amobarbital interviews . Journal of Nervous and Mental Disease vol. 177 , ( 7 ) 432 - 433 .