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Research

Publications: Prof Silvia Marino

Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L et al. ( 2022 ) . Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape . Elife vol. 11 ,
Marino S ( 2022 ) . SYNGN: A NOVEL PATIENT-SPECIFIC DRUG-MATCHING STRATEGY IN GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 24 , 3 - 3 .
Badodi S, Pomella N, Lim YM, Brandner S, Morrison G, Pollard SM, Zhang X, Zabet NR et al. ( 2022 ) . Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma . Neuro-Oncology vol. 24 , ( 8 ) 1273 - 1285 .
Badodi S, Pomella N, Zhang X, Zabet NR, Basson MA, Marino S ( 2022 ) . MEDB-23. Targeting epigenetic dysregulation in medulloblastoma with poor prognosis . Neuro-Oncology vol. 24 , ( Suppl 1 ) i109 - i110 .
Marino S ( 2022 ) . Subgroup-specific roles of primary cilia in medulloblastoma . Genes and Development vol. 36 , ( 11-12 ) 650 - 651 .
Badodi S, Pomella N, Zhang X, Zabet NR, Basson MA, Marino S ( 2022 ) . TARGETING EPIGENETIC DYSREGULATION IN MEDULLOBLASTOMA WITH POOR PROGNOSIS . NEURO-ONCOLOGY . vol. 24 , 109 - 109 .
Innes JA, Lowe AS, Fonseca R, Aley N, El-Hassan T, Constantinou M, Lau J, Eddaoudi A et al. ( 2022 ) . Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment . Laboratory Investigation vol. 102 , ( 2 ) 172 - 184 .
Marino S, Badodi S ( 2022 ) . Epigenetic mechanisms in paediatric brain tumours: regulators lose control . Biochemical Society Transactions
Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, Niklison-Chirou MV, Lim YM, Brandner S et al. ( 2021 ) . Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation . Nature Communications vol. 12 , ( 1 )
Marino S ( 2021 ) . Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma . Nature Communications
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B et al. ( 2021 ) . Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections . Science Advances vol. 7 , ( 37 )
Smets I, Marino S, Giovannoni G ( 2021 ) . Amyloidoma mimicking multiple sclerosis . Practical Neurology vol. 21 , ( 4 ) 344 - 345 .
Badodi S, Pomella N, Zhang X, Morrison G, Pollard SM, Bennett CD, Clifford SC, Peet A et al. ( 2021 ) . EMBR-10. INOSITOL TREATMENT INHIBITS MEDULLOBLASTOMA THROUGH SUPPRESSION OF EPIGENETIC-DRIVEN METABOLIC ADAPTATION . Neuro-Oncology vol. 23 , ( Supplement_1 ) i7 - i7 .
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Erratum: Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma (NAR Cancer (2021) 3:1 (zcab009) DOI: 10.1093/narcan/zcab009) . NAR Cancer vol. 3 , ( 2 )
Freire-Beneitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma . NAR Cancer vol. 3 , ( 1 )
Marino S, Gilbertson RJ ( 2021 ) . Harnessing brain development to understand brain tumours . Development (Cambridge) vol. 148 , ( 2 )
Sarić N, Selby M, Ramaswamy V, Kool M, Stockinger B, Hogstrand C, Williamson D, Marino S et al. ( 2020 ) . The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma . Scientific Reports vol. 10 , ( 1 )
Johansson P, Krona C, Kundu S, Doroszko M, Baskaran S, Schmidt L, Vinel C, Almstedt E et al. ( 2020 ) . A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma . Cell Reports vol. 32 , ( 2 ) Article 107897 , 107897 - 107897 .
Thomas R, Yeoh SA, Berkeley R, Woods A, Stevens M, Marino S, Radunovic A ( 2020 ) . Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: Case report . BMC Rheumatology vol. 4 , ( 1 )
Dumas A, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner T, Rees J, Aley N et al. ( 2020 ) . Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment . The EMBO Journal
Ricci B, Millner TO, Pomella N, Zhang X, Guglielmi L, Badodi S, Ceric D, Gemma C et al. ( 2020 ) . Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma . Oncogene . vol. 39 , 2523 - 2538 .
Millner TO, Ricci B, Zhang X, Pomella N, Marino S ( 2020 ) . Pre-clinical therapeutic targeting of a novel BMI1/ephrin connection in human glioblastomas . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 46 , 17 - 17 .
Marino S, Millner T ( 2020 ) . Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma . Oncogene vol. 39 , 2523 - 2538 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Correction to: C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (Acta Neuropathologica Communications (2019) 7:95 DOI: 10.1186/s40478-019-0739-x) . Acta Neuropathologica Communications vol. 7 , ( 1 )
Johansson P, Almstedt E, Doroszko M, Kundu S, Vinel C, Lane D, Nestor M, Marino S et al. ( 2019 ) . COMP-05. A DRUG ASSOCIATION MAP OF GLIOBLASTOMA INFORMS PRECISION TARGETING OF p53-DEPENDENT METABOLIC STATES . Neuro-Oncology vol. 21 , ( Supplement_6 ) vi62 - vi62 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, Rosser G, Li Y et al. ( 2019 ) . Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism . Neuro-Oncology . vol. 21 , iv9 - iv10 .
Innes J, Brandner S, Marino S ( 2019 ) . Multi-colour lineage tracing to asses intra-tumour heterogeneity in glioblastoma multiforme . Neuro-Oncology . vol. 21 , iv1 - iv1 .
Oliver Millner T, Ricci B, Zhang X, Pomella N, Marino S ( 2019 ) . Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma . Neuro-Oncology vol. 21 , ( Supplement_4 ) iv1 - iv2 .
Poole OV, Everett CM, Gandhi S, Marino S, Bugiardini E, Woodward C, Lam A, Quinlivan R et al. ( 2019 ) . Adult-onset Leigh syndrome linked to the novel stop codon mutation m.6579G>A in MT-CO1 . Mitochondrion vol. 47 , 294 - 297 .
Merve A, Zhang X, Pomella N, Acquati S, Hoeck JD, Dumas A, Rosser G, Li Y et al. ( 2019 ) . C-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism . Acta Neuropathologica Communications vol. 7 , ( 1 )
Merve A, Zhang X, Pomella N, Dumas A, Marino S ( 2019 ) . TMOD-05. C-MYC OVEREXPRESSION INDUCES CHOROID PLEXUS PAPILLOMAS THROUGH A T-CELL MEDIATED INFLAMMATORY MECHANISM . Neuro-Oncology vol. 21 , ( Supplement_2 ) ii122 - ii122 .
Merve A, Zhang X, Pomella N, Dumas A, Marino S ( 2019 ) . C-MYC OVEREXPRESSION INDUCES CHOROID PLEXUS PAPILLOMAS THROUGH A T-CELL MEDIATED INFLAMMATORY MECHANISM . NEURO-ONCOLOGY . vol. 21 , 122 - 122 .
Millner T, Ricci B, Zhang X, Pomella N, Rosser G, Marino S ( 2019 ) . A novel BMI1/Ephrin connection in human glioblastomas . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 45 , 42 - 43 .
Badodi S, Marino S, Guglielmi L ( 2019 ) . Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines . vol. 1869 , 23 - 36 .
Merve A, Millner TO, Marino S ( 2019 ) . Integrated phenotype–genotype approach in diagnosis and classification of common central nervous system tumours . Histopathology vol. 75 , ( 3 ) 299 - 311 .
O'Connor E, Vandrovcova J, Bugiardini E, Chelban V, Manole A, Davagnanam I, Wiethoff S, Pittman A et al. ( 2018 ) . Mutations in XRCC1 cause cerebellar ataxia and peripheral neuropathy . Journal of Neurology, Neurosurgery and Psychiatry vol. 89 , ( 11 ) 1230 - 1232 .
Sarkozy A, Torelli S, Mein R, Henderson M, Phadke R, Feng L, Sewry C, Ala P et al. ( 2018 ) . Mobility shift of beta-dystroglycan as a marker of GMPPB gene-related muscular dystrophy . Journal of Neurology, Neurosurgery and Psychiatry vol. 89 , ( 7 ) 762 - 768 .
Kurian KM, Jenkinson MD, Brennan PM, Grant R, Jefferies S, Rooney AG, Bulbeck H, Erridge SC et al. ( 2018 ) . Brain tumor research in the United Kingdom: Current perspective and future challenges. A strategy document from the NCRI brain tumor CSG . Neuro-Oncology Practice vol. 5 , ( 1 ) 10 - 17 .
Millner T, Ricci B, Marino S ( 2018 ) . A 3D intact tissue analysis approach for the cellular and molecular dissection of a novel BMI1/Ephrin connection in human glioblastomas (GBM) . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 44 , 42 - 43 .
Merve A, Zhang X, Dumas A, Acquati S, Jeyapalan J, Sabo A, Amati B, Behrens A et al. ( 2018 ) . c-Myc overexpression induces choroid plexus tumours and modulates inflammatory pathways . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 44 , 20 - 20 .
Ricci B, Guglielmi L, Barnes M, Marino S ( 2018 ) . Dissection of Bmi1-mediated epigenetic regulation of target genes in glioblastoma . Neuro-Oncology . vol. 20 , i3 - i3 .
MARINO S, BADODI S, Dubuc A, ZHANG X, ROSSER G, Da Cunha Jaeger M, Kameda-Smith M, Morrissy AS et al. ( 2017 ) . Convergence of BMI1 and CHD7 on ERK signalling in medulloblastoma . Cell Reports vol. 21 , ( 10 ) 2772 - 2784 .
Guglielmi L, Ricci B, Barnes M, Marino S ( 2017 ) . GENE-27. DIFFERENTIAL LEVELS OF H3K27me3 AT THE EfnA5 PROMOTER ARE CONTROLLED BY Bmi1 THROUGH MODULATION OF JmjD3 IN GLIOBLASTOMA . Neuro-Oncology vol. 19 , ( suppl_6 ) vi98 - vi98 .
Merve A, Marino S ( 2017 ) . TMOD-46. cMyc OVEREXPRESSION INDUCES CHOROID PLEXUS TUMOURS THROUGH MODULATION OF INFLAMMATORY PATHWAYS . Neuro-Oncology vol. 19 , ( suppl_6 ) vi264 - vi264 .
Guglielmi L, Ricci B, Barnes M, Marino S ( 2017 ) . DIFFERENTIAL LEVELS OF H3K27me3 AT THE EfnA5 PROMOTER ARE CONTROLLED BY Bmi1 THROUGH MODULATION OF JmjD3 IN GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 19 , 98 - 98 .
Merve A, Marino S ( 2017 ) . cMyc OVEREXPRESSION INDUCES CHOROID PLEXUS TUMOURS THROUGH MODULATION OF INFLAMMATORY PATHWAYS . NEURO-ONCOLOGY . vol. 19 , 264 - 264 .
Niklison-Chirou MV, Erngren I, Engskog M, Haglöf J, Picard D, Remke M, McPolin P, Selby M et al. ( 2017 ) . TAp73 is a marker of glutamine addiction in medulloblastoma . Genes and Development
MARINO S, Dibenedetto S, Niklison-Chirou M, Cabrera C, Ellis M, Robson LG, Knopp P, Barnes M et al. ( 2017 ) . Enhanced energetic state and protection from oxidative stress in human myoblasts overexpressing BMI1 . Stem Cell Reports
Merve A, Acquati S, Hoeck J, Jeyapalan J, Behrens A, Marino S ( 2017 ) . CMYC OVEREXPRESSION INDUCES CHOROID PLEXUS TUMOURS THROUGH MODULATION OF INFLAMMATORY PATHWAYS . NEURO-ONCOLOGY . vol. 19 , 48 - 48 .
Badodi S, Zhang X, Dubuc A, Taylor MD, Marino S ( 2017 ) . CONVERGENCE OF BMI1 AND CHD7 ON ERK SIGNALLING IN MEDULLOBLASTOMA . NEURO-ONCOLOGY . vol. 19 , 40 - 40 .
Guillotin D, Austin P, Begum R, Freitas MO, Merve A, Brend T, Short S, Marino S et al. ( 2017 ) . Drug-repositioning screens identify triamterene as a selective drug for the treatment of DNA mismatch repair deficient cells . Clinical Cancer Research vol. 23 , ( 11 ) 2880 - 2890 .
Badodi S, Zhang X, Dubuc A, Taylor MD, Marino S ( 2017 ) . MEDU-13. CONVERGENCE OF BMI1 AND CHD7 ON ERK SIGNALLING IN MEDULLOBLASTOMA . Neuro-Oncology vol. 19 , ( suppl_4 ) iv40 - iv40 .
Merve A, Acquati S, Hoeck J, Jeyapalan J, Behrens A, Marino S ( 2017 ) . TMOD-01. CMYC OVEREXPRESSION INDUCES CHOROID PLEXUS TUMOURS THROUGH MODULATION OF INFLAMMATORY PATHWAYS . Neuro-Oncology vol. 19 , ( suppl_4 ) iv48 - iv48 .
MARINO S, Dawes W ( 2017 ) . Moderate-grade germinal matrix haemorrhage activates cell division in the neonatal mouse subventricular zone . Developmental Neuroscience vol. 38 , 430 - 444 .
Merve A, Acquati S, Hoeck J, Jeyapalan J, Behrens A, Marino S ( 2017 ) . Role of Myc in Choroid Plexus Tumour Pathogenesis . JOURNAL OF PATHOLOGY . vol. 241 , S5 - S5 .
Millner TO, Dikou ML, Marino S ( 2017 ) . Tissue Clearing for Brain Tumour Research . JOURNAL OF PATHOLOGY . vol. 241 , S18 - S18 .
Dikou ML, Marino S, Millner TO ( 2017 ) . Optimising tissue clearing for brain tumour research . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 43 , 45 - 45 .
Marino S, Dubuc A, Taylor M, Zhang X ( 2017 ) . MOLECULAR CONVERGENCE OF CHD7 AND BMI1 IN MEDULLOBLASTOMA PATHOGENESIS . NEURO-ONCOLOGY . vol. 19 , 124 - 124 .
Marino S, Dubuc A, Taylor M, Zhang X ( 2017 ) . OP02. MOLECULAR CONVERGENCE OF CHD7 AND BMI1 IN MEDULLOBLASTOMA PATHOGENESIS . Neuro-Oncology vol. 19 , ( suppl_1 ) i24 - i24 .
Sibilia M, Wagner B, Hoebertz A, Elliott C, Marino S, Jochum W, Wagner EF ( 2016 ) . Correction: Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart . Development vol. 143 , ( 24 )
Leto K, Arancillo M, Becker EBE, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I et al. ( 2016 ) . Consensus Paper: Cerebellar Development . Cerebellum vol. 15 , ( 6 ) 789 - 828 .
Marino S, Dubuc A, Jaeger MDC, Morrissy S, Taylor M, Zhang X ( 2016 ) . CONVERGENCE OF BMI1 AND CHD7 ON ERK SIGNALLING IN MEDULLOBLASTOMA . NEURO-ONCOLOGY . vol. 18 , 210 - 210 .
Marino S, Dubuc A, Da Cunha Jaeger M, Morrissy S, Taylor M, Zhang X ( 2016 ) . TMOD-17. CONVERGENCE OF BMI1 AND CHD7 ON ERK SIGNALLING IN MEDULLOBLASTOMA . Neuro-Oncology vol. 18 , ( suppl_6 ) vi210 - vi210 .
Torelli S, Sarkozy A, Mein R, Yau M, Hammans S, Radunovic A, Henderson M, Walker M et al. ( 2016 ) . P.260 Mobility shift of beta-dystroglycan combined with reduced laminin alpha2 expression is a marker of genetic defects in the GMPPB gene . Neuromuscular Disorders . vol. 26 ,
Papadimitriou SA, Robin MP, Ceric D, O'Reilly RK, Marino S, Resmini M ( 2016 ) . Fluorescent polymeric nanovehicles for neural stem cell modulation . Nanoscale vol. 8 , ( 39 ) 17340 - 17349 .
Marino S, Di Foggia V ( 2016 ) . Invited Review: Polycomb group genes in the regeneration of the healthy and pathological skeletal muscle . Neuropathology and Applied Neurobiology vol. 42 , ( 5 ) 407 - 422 .
Shah A, Hersheson J, Novak M, Davis A, Stevens M, Espasandin M, Vaidya S, Marino S et al. ( 2016 ) . Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy: case series and magnetic resonance imaging findings . EUROPEAN JOURNAL OF NEUROLOGY . vol. 23 , 552 - 552 .
Blake SM, Stricker SH, Halavach H, Poetsch AR, Cresswell G, Kelly G, Kanu N, Marino S et al. ( 2016 ) . Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation . eLife vol. 5 , ( MARCH2016 )
Millner TO, Marino S ( 2016 ) . Tissue clearing for brain tumour research . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 42 , 35 - 35 .
Merve A, Acquati S, Hoeck J, Jeyapalan J, Behrens A, Marino S ( 2016 ) . c-Myc in choroid plexus tumourigenesis . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 42 , 21 - 21 .
Hadjiandreou M, Chilima CAP, Marino S, Niklison-Chirou MV ( 2015 ) . PO19TARGETING ASCT2 BLOCKS GROWTH AND MIGRATION IN A MEDULLOBLASTOMA CELL LINE . Neuro-Oncology vol. 17 , ( suppl_8 ) viii3 - viii4 .
Ricci B, Barnes M, Marino S ( 2015 ) . A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA . NEURO-ONCOLOGY . vol. 17 , 8 - 8 .
Hadjiandreou M, Chilima CAP, Marino S, Niklison-Chirou MV ( 2015 ) . TARGETING ASCT2 BLOCKS GROWTH AND MIGRATION IN A MEDULLOBLASTOMA CELL LINE . NEURO-ONCOLOGY . vol. 17 , 3 - 4 .
Merve A, Zhang X, Acquati S, Marino S ( 2015 ) . c-Myc is expressed in a proportion of human choroid plexus tumours and its overexpression in the developing mouse CNS induces choroid plexus tumorigenesis . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 41 , 13 - 14 .
Chapagain A, Marino S, Ashman N ( 2015 ) . The Case . Kidney International vol. 87 , ( 1 ) 247 - 248 .
Di Foggia V, Zhang X, Licastro D, Gerli MFM, Phadke R, Muntoni F, Mourikis P, Tajbakhsh S et al. ( 2014 ) . Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy . Journal of Cell Biology vol. 207 , ( 5 )
Ricci B, Ceric D, Barnes M, Marino S ( 2014 ) . A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . NEURO-ONCOLOGY . vol. 16 ,
Brierley DJ, Locke M, Merve A, Marino S, Martin SA ( 2014 ) . O06TARGETING FOXM1 AS A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF MSH6 DEFICIENT TEMOZOLOMIDE-RESISTANT GLIOBLASTOMA . Neuro-Oncology vol. 16 , ( suppl_6 ) vi14 - vi14 .
Ricci B, Ceric D, Barnes M, Marino S ( 2014 ) . O10A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . Neuro-Oncology vol. 16 , ( suppl_6 ) vi14 - vi14 .
Merve A, Acquati S, Marino S ( 2014 ) . OP10ROLE OF C-MYC IN CHOROID PLEXUS TUMOURS . Neuro-Oncology vol. 16 , ( suppl_6 ) vi17 - vi18 .
Merve A, Acquati S, Marino S ( 2014 ) . ROLE OF C-MYC IN CHOROID PLEXUS TUMOURS . NEURO-ONCOLOGY . vol. 16 ,
Marino S, Di Foggia V ( 2014 ) . Bmi1 protects satellite cells against oxidative stress induced DNA damage . BRAIN PATHOLOGY . vol. 24 , 60 - 60 .
Marino S, Ceric D, Ricci B, Barnes M ( 2014 ) . O4.07A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . Neuro-Oncology vol. 16 , ( suppl_2 ) ii8 - ii8 .
Marino S, Ricci B, Greco A, Acquati S ( 2014 ) . A NOVEL POLYCOMB FEED FORWARD LOOP IN GLIOBLASTOMA MULTIFORME . NEURO-ONCOLOGY . vol. 16 ,
Marino S, Ricci B, Greco A, Acquati S ( 2014 ) . A novel polycomb feed forward loop in glioblastoma multiforme . Neuro Oncol vol. 16 Suppl 3 ,
Marino S, Zhang X, Robson LG, Di Foggia V ( 2014 ) . Bmil protects satellite cells against oxidative stress induced DNA damage . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 40 , 14 - 15 .
Dibenedetto S, East M, Baithun M, Robson LG, Radunovic A, Marino S ( 2014 ) . P67 Characterisation of the expression of Polycomb Group Genes in human neuromuscular diseases . Neuromuscular Disorders vol. 24 , s24 - s25 .
Merve A, Dubuc A, Zhang X, Remke M, Baxter P, Li X, Taylor MD, Marino S ( 2014 ) . Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 40 , 24 - 24 .
Merve A, Dubuc AM, Zhang X, Remke M, Baxter PA, Li X-N, Taylor MD, Marino S ( 2014 ) . Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion . Acta Neuropathol Commun vol. 2 ,
Di Foggia V, Zhang X, Licastro D, Gerli MFM, Phadke R, Muntoni F, Mourikis P, Tajbakhsh S et al. ( 2014 ) . Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy . Journal of Experimental Medicine vol. 211 , ( 13 ) 2617 - 2633 .
Merve A, Marino S ( 2013 ) . Bmi1 controls medulloblastoma invasion through inhibition of BMP-mediated cell adhesion . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . Conference: 114th Meeting of the British-Neuropathological-Society / Symposium on Advances in Motor Neuron Diseases ( Inst Child Hlth, London, ENGLAND ) from: 13/03/2013 to: 15/03/2012 , vol. 39 SI , 21 - 21 .
Di Foggia V, Zhang X, Robson LG, Marino S ( 2013 ) . Bmi1 controls proliferation and maintenance of satellite cells and plays an important role in muscle regeneration . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 39 , 47 - 47 .
Dawes WJ, Marino S ( 2013 ) . The effect of germinal matrix haemorrhage on postnatal oligo/neurogenesis . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . Conference: 114th Meeting of the British-Neuropathological-Society / Symposium on Advances in Motor Neuron Diseases ( Inst Child Hlth, London, ENGLAND ) from: 13/03/2013 to: 15/03/2012 , vol. 39 , 14 - 15 .
Behesti H, Bhagat H, Dubuc AM, Taylor MD, Marino S ( 2013 ) . Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation . Dis Model Mech vol. 6 , ( 1 ) 49 - 63 .
Acquati S, Greco A, Licastro D, Bhagat H, Ceric D, Rossini Z, Grieve J, Shaked-Rabi M et al. ( 2013 ) . Epigenetic regulation of survivin by Bmi1 is cell type specific during corticogenesis and in gliomas . Stem Cells vol. 31 , ( 1 ) 190 - 202 .
Di Foggia V, Zhang X, Marino S, Robson LG ( 2012 ) . Bmi1 controls satellite cells proliferation and maintenance and plays an important role in muscle regeneration . NEUROMUSCULAR DISORDERS . vol. 22 , S5 - S5 .
Marino S ( 2012 ) . Medulloblastoma: From Genomics to Mouse Models . JOURNAL OF PATHOLOGY . vol. 226 , S6 - S6 .
Di Foggia V, Zhang X, Marino S, Robson LG ( 2012 ) . O07 Bmi1 controls satellite cells proliferation and maintenance and plays an important role in muscle regeneration . Neuromuscular Disorders vol. 22 ,
Zhang X, Bhagat H, Di Foggia V, Radunovic A, Robson LG, Marino S ( 2012 ) . P32 Polycomb group genes and the regenerative process in the aged and pathological human muscle . Neuromuscular Disorders vol. 22 ,
Zhang X, Bhagat H, Di Foggia V, Radunovic A, Robson LG, Marino S ( 2012 ) . Polycomb group genes and the regenerative process in the aged and pathological human muscle . NEUROMUSCULAR DISORDERS . vol. 22 , S15 - S15 .
Ahmad H, Radunovic A, Davis A, Marino S, Jungbluth H, Aoyama C, Abbs S, Moore D ( 2012 ) . Novel Choline Kinase Beta Gene Mutation Associated with Exercise Induced Myalgia and Mitochondrial Changes . ANNALS OF NEUROLOGY . vol. 72 , S64 - S64 .
Marshall C, Ahmad H, Parkin N, Abbs S, Marino S, Vaidya S, Jungbluth H, Radunovic A ( 2012 ) . Phenotypic Diversity of Mutations in the Ryanodine Receptor (RYR1): A Series of Six Cases . ANNALS OF NEUROLOGY . vol. 72 , S73 - S73 .
Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, Walklin HJ, Johnstone JV, Ibrahim NI et al. ( 2011 ) . The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles . Biomaterials vol. 32 , ( 33 ) 8538 - 8547 .
Zhang X, Santuccione A, Leung C, Marino S ( 2011 ) . Differentiation of postnatal cerebellar glial progenitors is controlled by Bmi1 through BMP pathway inhibition . Glia vol. 59 , ( 7 ) 1118 - 1131 .
Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, Walklin H, Johnstone J, Ibrahim N et al. ( 2011 ) . CD95 Targetted Microparticles Enhance Intracellular Drug Delivery and Increase the Efficacy of Paclitaxel Therapy in an Orthotopic Ovarian Cancer Model . JOURNAL OF PATHOLOGY . vol. 224 , S3 - S3 .
Yadirgi G, Leinster V, Acquati S, Bhagat H, Shakhova O, Marino S ( 2011 ) . Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo . Stem Cells vol. 29 , ( 4 ) 700 - 712 .
Merve A, Zhang X, Marino S ( 2011 ) . BMI-1 GENE SILENCING INFLUENCES CELL ADHESION AND INVASIVE PROPERTIES OF MEDULLOBLASTOMA CELLS VIA INHIBITION OF BMP PATHWAY . NEURO-ONCOLOGY . vol. 13 , 8 - 8 .
Robson LG, Di Foggia V, Radunovic A, Bird K, Zhang X, Marino S ( 2011 ) . Bmi1 is expressed in postnatal myogenic satellite cells, controls their maintenance and plays an essential role in repeated muscle regeneration . PLoS One vol. 6 , ( 11 )
Greco A, Acquati S, Marino S ( 2011 ) . ROLE OF BMI1 OVEREXPRESSION IN DNA DAMAGE IN NEURAL STEM CELLS AND IN GLIOBLASTOMA INITIATING CELLS . NEURO-ONCOLOGY . vol. 13 , 4 - 4 .
Subkhankulova T, Zhang X, Leung C, Marino S ( 2010 ) . Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors . Mol Cell Neurosci vol. 45 , ( 2 ) 151 - 162 .
Amsen E, Storey K, Marino S ( 2010 ) . An interview with Kate Storey and Silvia Marino . DEVELOPMENT vol. 137 , ( 12 ) 1931 - 1932 .
Belcher R, Chahal HS, Evanson J, Afshar F, Marino S, Grossman AB ( 2010 ) . Recurrent pituitary ependymoma: a complex clinical problem . Pituitary vol. 13 , ( 2 ) 176 - 182 .
Zhang X, Di Foggia V, Robson L, Marino S ( 2010 ) . Analysis of the molecular mechanisms mediating Bmi1 function in satellite cells . NEUROMUSCULAR DISORDERS . vol. 20 , S16 - S16 .
Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S, Santuccione A, Bernays R et al. ( 2010 ) . Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas . ONCOGENE vol. 29 , ( 12 ) 1845 - 1856 .
Di Foggia V, Zhang X, Marino S, Robson L ( 2010 ) . Does Bmi-1 over-expression increase myogenic satellite cells self-renewal capacity in ageing muscle? . NEUROMUSCULAR DISORDERS . vol. 20 , S16 - S16 .
Behesti H, Leung C, Marino S ( 2009 ) . Bmi1 overexpression in cerebellar development and tumourigenesis . MECHANISMS OF DEVELOPMENT . vol. 126 , S63 - S64 .
Sutter R, Shakhova O, Schraml P, Marino S ( 2009 ) . Cerebellar stem cells act as medulloblastoma initiating cells in a mouse model and a neural stem cell signature characterises a subset of human medulloblastoma . MECHANISMS OF DEVELOPMENT . vol. 126 , S65 - S65 .
Zhang XY, Marino S ( 2009 ) . Fate specification of glial progenitors but not proliferation of granule cell progenitors is controlled by Bmi1 through BMP pathway inhibition during cerebellar development . MECHANISMS OF DEVELOPMENT . vol. 126 , S326 - S326 .
King NKK, Joshi SM, Marino S, Yeh JS, Ellamushi H ( 2009 ) . Dorsally located endodermal cyst: case report and review . Br J Neurosurg vol. 23 , ( 3 ) 318 - 320 .
Behesti H, Marino S ( 2009 ) . Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesis . Int J Biochem Cell Biol vol. 41 , ( 3 ) 435 - 445 .
Yadirgi G, Marino S ( 2009 ) . Adult neural stem cells and their role in brain pathology . J Pathol vol. 217 , ( 2 ) 242 - 253 .
Sutter R, Shakhova O, Penkar S, Bernays R, Grotzer M, Schraml P, Marino S ( 2009 ) . Cerebellar stem cells act as medulloblastoma initiating cells in a mouse model and a neural stem cell signature characterises a subset of human medulloblastoma . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 35 , 5 - 5 .
Robson L, Marino S ( 2009 ) . The role of Polycomb gene Bmi1 in the maintenance of the satellite cells in skeletal muscle . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 35 , 7 - 7 .
Perez D, Herrmann T, Jungbluth AA, Samartzis P, Spagnoli G, Demartines N, Clavien PA, Marino S et al. ( 2008 ) . Cancer testis antigen expression in gastrointestinal stromal tumors: New markers for early recurrence . INT J CANCER vol. 123 , ( 7 ) 1551 - 1555 .
Mihic-Probst D, Kuster A, Kilgus S, Bode-Lesniewska B, Ingold-Heppner B, Leung C, Storz M, Seifert B et al. ( 2008 ) . Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma . VIRCHOWS ARCH vol. 452 , S39 - S39 .
Sutter R, Penkar S, Shakhova O, Marino S ( 2008 ) . Role of cerebellar stem cells in medulloblastoma pathogenesis . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 34 , 35 - 35 .
Sutter R, Yadirgi G, Marino S ( 2007 ) . Neural stem cells, tumour stem cells and brain tumours: Dangerous relationships? . BBA-REV CANCER vol. 1776 , ( 2 ) 125 - 137 .
Mihic-Probst D, Kuster A, Kilgus S, Bode-Lesniewska B, Ingold-Heppner B, Leung C, Storz M, Seifert B et al. ( 2007 ) . Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma . INT J CANCER vol. 121 , ( 8 ) 1764 - 1770 .
Perez D, Samartzis N, Jungbluth A, Marino S, Clavien P, Jaeger D ( 2007 ) . Cancer testis antigen expression in gastrointestinal stromal tumor: Risk factor for tumor recurrence . ANNALS OF ONCOLOGY . vol. 18 , VII12 - VII12 .
Shakhova O, Leung C, van Montfort E, Berns A, Marino S ( 2006 ) . Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2 . CANCER RES vol. 66 , ( 10 ) 5190 - 5200 .
Shakhova O, Leung C, Marino S ( 2005 ) . Bmi1 in development and tumorigenesis of the central nervous system . Journal of Molecular Medicine vol. 83 , ( 8 ) 596 - 600 .
Bruggeman SWM, Valk-Lingbeek ME, van der Stoop PPM, Jacobs JJL, Kieboom K, Tanger E, Hulsman D, Leung C et al. ( 2005 ) . Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice . GENE DEV vol. 19 , ( 12 ) 1438 - 1443 .
Marino S ( 2005 ) . Medulloblastoma: developmental mechanisms out of control . TRENDS MOL MED vol. 11 , ( 1 ) 17 - 22 .
Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, van Lohuizen M, Marino S ( 2004 ) . Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas . NATURE vol. 428 , ( 6980 ) 337 - 341 .
Roth JF, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, Wittwer J, Schorle H et al. ( 2003 ) . Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5 . EMBO J vol. 22 , ( 19 ) 5186 - 5196 .
Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, Marino S, Wittwer J, Scheidweiler A et al. ( 2003 ) . Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation . EMBO J vol. 22 , ( 19 ) 5175 - 5185 .
Sibilia M, Wagner B, Hoebertz A, Elliott C, Marino S, Jochum W, Wagner EF ( 2003 ) . Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart . DEVELOPMENT vol. 130 , ( 19 ) 4515 - 4525 .
Marino S, Hoogervoorst D, Brandner S, Berns A ( 2003 ) . Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence . DEVELOPMENT vol. 130 , ( 15 ) 3359 - 3368 .
Voncken JW, Roelen BAJ, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M ( 2003 ) . Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition . P NATL ACAD SCI USA vol. 100 , ( 5 ) 2468 - 2473 .
Marino S, Krimpenfort P, Leung C, van der Korput HAGM, Trapman J, Camenisch I, Berns A, Brandner S ( 2002 ) . PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum . DEVELOPMENT vol. 129 , ( 14 ) 3513 - 3522 .
Schwarz U, Marino S, Hess K ( 2002 ) . Marburg's encephalitis in a young woman . EUR NEUROL vol. 48 , ( 1 ) 42 - 44 .
Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey AI et al. ( 2002 ) . Neuropathology of genetically engineered mice: Consensus report and recommendations from an international forum . Oncogene vol. 21 , ( 49 ) 7453 - 7463 .
Brandner S, Krimpenfort P, Berns A, Marino S ( 2001 ) . The role of PTEN in cerebellar development and differentiation . ACTA NEUROPATHOL vol. 102 , ( 5 ) 520 - 520 .
Marino S, Vooijs M, Van Der Gulden H, Jonkers J, Berns A ( 2000 ) . Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum . Genes and Development vol. 14 , ( 8 ) 994 - 1004 .
Benninger Y, Marino S, Hardegger R, Weissmann C, Aguzzi A, Brandner S ( 2000 ) . Differentiation and histological analysis of embryonic stem cell-derived neural transplants in mice . Brain Pathology vol. 10 , ( 3 ) 330 - 341 .
Berns A, Vooijs M, Marino S, Jonkers J, Meuwissen R, Vink J, Van der Gulden H, Krimpenfort P ( 1999 ) . Knock-out mice in cancer research . European Journal of Cancer vol. 35 ,
Jacobs JL, Kieboom K, Marino S, DePinho RA, Van Lohuizen M ( 1999 ) . The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus . Nature vol. 397 , ( 6715 ) 164 - 168 .
Lichtlen P, Günes Ç, Heuchel R, Georgiev O, Müller K-H, Blüthmann H, Marino S, Aguzzi A et al. ( 1999 ) . Embryonic Liver Degeneration and Increased Sensitivity Towards Heavy Metal and H2O2 in Mice Lacking the Metal-Responsive Transcription Factor MTF-1 . Metals and Genetics ,
Günes Ç, Heuchel R, Georgiev O, Müller K-H, Marino S, Aguzzi A, Blüthmann H, Schaffner W ( 1999 ) . Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1 . Metallothionein IV ,
Günes C, Heuchel R, Georgiev O, Müller KH, Lichtlen P, Blüthmann H, Marino S, Aguzzi A et al. ( 1998 ) . Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1 . EMBO Journal vol. 17 , ( 10 ) 2846 - 2854 .
Lampe J, Marino S, Rethwilm A, Aguzzi A ( 1998 ) . Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus . Neuropathology and Applied Neurobiology vol. 24 , ( 1 ) 36 - 43 .
Hauser V, Marino S, Schwarz U, Aguzzi A, Hess K ( 1997 ) . Acute fatal encephalomyelitis disseminata (marburg type) . Schweizer Archiv fur Neurologie und Psychiatrie vol. 148 , ( 5 )
Aguzzi A, Brandner S, Marino S, Steinbach JP ( 1996 ) . Transgenic and knockout mice in the study of neurodegenerative diseases . Journal of Molecular Medicine vol. 74 , ( 3 ) 111 - 126 .
Tschopp RR, Brandner S, Marino S, Bothe K, Horak I, Rethwilm A, Aguzzi A ( 1996 ) . Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice . Virology vol. 216 , ( 2 ) 338 - 346 .
Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C et al. ( 1996 ) . Normal host prion protein necessary for scrapie-induced neurotoxicity . Nature vol. 379 , ( 6563 ) 339 - 343 .
Aguzzi A, Marino S, Tschopp R, Rethwilm A ( 1996 ) . Regulation of expression and pathogenic potential of human foamy virus in vitro and in transgenic mice . Current Topics in Microbiology and Immunology vol. 206 , 242 - 273 .
Varga Z, Vajtai I, Marino S, Schäuble B, Yonekawa Y, Aguzzi A ( 1996 ) . Tubular adenoma of the choroid plexus: Evidence for glandular differentiation of the neuroepithelium . Pathology Research and Practice vol. 192 , ( 8 ) 840 - 844 .
Schiffer D, Cavalla P, Migheli A, Chiò A, Giordana MT, Marino S, Attanasio A ( 1995 ) . Apoptosis and cell proliferation in human neuroepithelial tumors . Neuroscience Letters vol. 195 , ( 2 ) 81 - 84 .
Giordana MT, Bradac GB, Pagni CA, Marino S, Attanasio A ( 1995 ) . Primary diffuse leptomeningeal gliomatosis with anaplastic features . Acta Neurochirurgica vol. 132 , ( 1-3 ) 154 - 159 .
Marino S, Kretschmer C, Brandner S, Cavard C, Zider A, Briand P, Isenmann S, Wagner EF et al. ( 1995 ) . Activation of HIV transcription by human foamy virus in transgenic mice . Laboratory Investigation vol. 73 , ( 1 ) 103 - 110 .
Giordana MT, Cavalla P, Chio A, Marino S, Soffietti R, Vigliani MC, Schiffer D ( 1995 ) . Prognostic factors in adult medulloblastoma. A clinico-pathologic study . Tumori vol. 81 , ( 5 ) 338 - 346 .
Aguzzi A, Brandner S, Tschopp R, Marino S ( 1995 ) . Transgenic mouse models for human retroviral diseases . Neuropathology and Applied Neurobiology . vol. 21 , 24 - 25 .
Migheli A, Cavalla P, Marino S, Schiffer D ( 1994 ) . A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks . J Neuropathol Exp Neurol vol. 53 , ( 6 ) 606 - 616 .
Schiffer D, Cavalla P, Chiò A, Giordana MT, Marino S, Mauro A, Migheli A ( 1994 ) . Tumor cell proliferation and apoptosis in medulloblastoma . Acta Neuropathologica vol. 87 , ( 4 ) 362 - 370 .
Marino S, Brandner S ( 1994 ) . The knock-out approach in the analysis of development and neoplasia, at Schloss Reisenburg . Brain Pathology . vol. 4 , 285 - 286 .
Giordana MT, Cavalla P, Chió A, Marino S, Viqliani MC, Schiffer D ( 1993 ) . USEFULNESS OF Ki-67, CLONE MIB-1, AS A PROGNOSTIC FACTOR IN EPENDYMOMAS . Journal of Neuropathology & Experimental Neurology vol. 52 , ( 3 )