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Research

Publications: Dr Neil McCarthy

Ngan SFC, McCarthy NE, Sze SK ( 2023 ) . pSILAC-Based Determination of Cellular Protein Sorting into Extracellular Vesicles . Methods in molecular biology (Clifton, N.J.) vol. 2603 , 43 - 58 .
Mathew L, Savage M, Pardieu C, O’Brien M, Sze SK, Eberl M, Stagg A, Gasparetto M et al. ( 2022 ) . OP37 Bacterial suppression of intestinal fungi via activation of human gut Vδ2+ T-cells . Journal of Crohn's and Colitis vol. 16 , ( Supplement_1 ) i043 - i044 .
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Stagg AJ, Lindsay JO, Whelan K ( 2021 ) . Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel disease . Clinical Nutrition vol. 40 , ( 8 ) 5009 - 5019 .
Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SFC, Liou KCK, Lynn SES, Ng SS et al. ( 2021 ) . Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis . Atherosclerosis vol. 324 , 58 - 68 .
Panoskaltsis N, McCarthy NE, Stagg AJ, Mummery CJ, Husni M, Arebi N, Greenstein D, Price CL et al. ( 2021 ) . Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm . Cancer Immunology, Immunotherapy vol. 70 , ( 4 ) 1127 - 1142 .
Panoskaltsis N, McCarthy NE, Knight SC ( 2021 ) . Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm . Cancer Immunology, Immunotherapy vol. 70 , ( 4 ) 1155 - 1160 .
McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC, Panoskaltsis N ( 2020 ) . Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells . Cancer Immunology Immunotherapy
Tse SW, Tan CF, Park JE, Gnanasekaran J, Gupta N, Low JK, Yeoh KW, Chng WJ et al. ( 2020 ) . Microenvironmental hypoxia induces dynamic changes in lung cancer synthesis and secretion of extracellular vesicles . Cancers vol. 12 , ( 10 ) 1 - 25 .
Ng SS, Park JE, Meng W, Chen CP, Kalaria RN, Mccarthy NE, Sze SK ( 2020 ) . Pulsed SILAM Reveals in Vivo Dynamics of Murine Brain Protein Translation . ACS Omega vol. 5 , ( 23 ) 13528 - 13540 .
Gill US, McCarthy NE ( 2019 ) . CD4 T cells in hepatitis B virus: "You don't have to be cytotoxic to work here and help" . Journal of Hepatology
Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N, Sze SK ( 2019 ) . ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer . Oncotarget vol. 10 , ( 57 ) 5970 - 5982 .
Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H et al. ( 2019 ) . Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial . Gastroenterology
Hoti I, McCarthy N, Giles E, Ayada I, Harrow P, Gordon H, Stagg A, Lindsay J ( 2019 ) . P092 Circulating classical monocytes and intestinal macrophages exhibit reduced response to IL-10 in IBD . Journal of Crohn's and Colitis . vol. 13 , s131 - s132 .
Cox S, Stagg A, Fromentin S, Ehrlich D, McCarthy N, Galleron N, Levenez F, Lomer M et al. ( 2018 ) . ADWE-09 Low fodmap diet improves functional-like gastrointestinal symptoms but reduces bifidobacteria in quiescent inflammatory bowel disease . Gut . Conference: Small Bowel & Nutrition vol. 67 ,
McCarthy NE, Eberl M ( 2018 ) . Human γδ T-Cell Control of Mucosal Immunity and Inflammation . Front Immunol vol. 9 , 985 - 985 .
Cox SR, Stagg AJ, Fromentin S, Ehrlich SD, McCarthy NE, Galleron N, Levenez F, Lomer M et al. ( 2018 ) . 902 - Low Fodmap Diet Improves Functional-Like Gastrointestinal Symptoms but Reduces Bifidobacteria and Faecalibacterium Prausnitzii in Quiescent Inflammatory Bowel Disease: A Randomised Controlled Trial and Metagenomic Analysis . Gastroenterology vol. 154 , ( 6 ) s - 177 .
Harrow P, McCarthy N, Stagg A, Lindsay J ( 2018 ) . DOP017 Increased intestinal aryl hydrocarbon receptor expression and pathway sensitivity in Crohn’s disease . Journal of Crohn's and Colitis vol. 12 , ( supplement_1 ) s041 - s041 .
Cox S, Stagg A, Fromentin S, Ehrlich D, McCarthy N, Galleron N, Levenez F, Lomer M et al. ( 2018 ) . DOP086 Low FODMAP diet improves functional-like gastrointestinal symptoms but reduces bifidobacteria and faecalibacterium prausnitzii in Quiescent inflammatory bowel disease: a randomised controlled trial and metagenomic analysis . Journal of Crohn's and Colitis vol. 12 , ( supplement_1 ) s087 - s087 .
MCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B, Eberl M ( 2017 ) . Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin . Journal of Immunology
McCarthy N, Gordon H, Rahman S, Harrow P, Stagg A, Lindsay J ( 2017 ) . P059 Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's disease . J Crohns Colitis . vol. 11 ,
Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, Macdonald TT, Lindsay JO, Stagg AJ ( 2017 ) . Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease . Mucosal Immunology vol. 10 , ( 1 ) 184 - 193 .
Petty RD, McCarthy NE, Dieu RL, Kerr JR ( 2016 ) . MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential diagnostic biomarkers in natural killer (NK) cells of patients with Chronic Fatigue Syndrome (CFS)/myalgic encephalomyelitis (ME) . PLoS ONE vol. 11 , ( 3 )
McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM et al. ( 2015 ) . Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease . Journal of Clinical Investigation vol. 125 , ( 8 ) 3215 - 3225 .
Brugha R, Mushtaq N, McCarthy NE, Stagg AJ, Grigg J ( 2015 ) . Respiratory tract dendritic cells in paediatric asthma . Clin Exp Allergy vol. 45 , ( 3 ) 624 - 631 .
Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO, Stagg AJ ( 2014 ) . Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease . Gastroenterology vol. 146 , ( 5 )
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T et al. ( 2014 ) . Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings . Gut
McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al. ( 2013 ) . Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells . J Immunol vol. 191 , ( 5 ) 2752 - 2763 .
Hedin C, McCarthy NE, Louis P, Farquharson F, McCartney S, Taylor K, Prescott NJ, Murrells T et al. ( 2013 ) . 260 Siblings of Patients With Crohn's Disease Have a Distinct Microbiological and Immune Phenotype Compared to Healthy Controls: Insights Into Disease Pathogenesis . Gastroenterology vol. 144 , ( 5 )
Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J et al. ( 2012 ) . Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease . Clin Exp Immunol vol. 170 , ( 2 ) 122 - 130 .
Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA et al. ( 2012 ) . Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment . Inflamm Bowel Dis vol. 18 , ( 7 ) 1275 - 1286 .
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG et al. ( 2012 ) . Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota . INFLAMMATORY BOWEL DISEASES vol. 18 , ( 6 ) 1092 - 1100 .
Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al. ( 2011 ) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease . Inflamm Bowel Dis vol. 17 , ( 10 ) 2027 - 2037 .
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD et al. ( 2011 ) . Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease . Gut vol. 60 , ( 7 ) 923 - 929 .
Hedin CR, McCarthy NE, Bhattacharjee S, James G, Whelan K, Lindsay JO, Stagg AJ ( 2011 ) . Expansion of Vδ2+T-Cells Occurs in Crohn's Disease Patients and Their Siblings: Impact of Therapy and Implications for Pathogenesis . Gastroenterology vol. 140 , ( 5 ) s - 489 .
Ng SC, Benjamin JL, McCarthy NE, Hedin CR, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al. ( 2010 ) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease . Inflamm Bowel Dis .
Mann ER, Ordiz DB, Al-Hassi HO, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart A et al. ( 2010 ) . W1813 Human Dendritic Cell Migration Markers and Function Determine T-Cell Migration Patterns and Properties . Gastroenterology vol. 138 , ( 5 ) s - 745 .
Mann ER, Al-Hassi HO, Clark SK, McCarthy NE, Cochrane SA, Hart A, Stagg AJ, Knight SC ( 2009 ) . M1677 Imprinting of Lymphocyte Homing to Skin and Gut By Human Tissue DC . Gastroenterology vol. 136 , ( 5 ) a - 408 .
Mann ER, McCarthy NE, Milestone AN, Cochrane SA, Stagg AJ, Hart A, Knight SC ( 2009 ) . S1700 The Role of Human γδ T-Cells in Inflammatory Bowel Disease . Gastroenterology vol. 136 , ( 5 ) a - 252 .
Ng SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ, Knight SC ( 2009 ) . S1750 Distinct Cytokine Patterns from Multiplex Profiles of Patients with Inflammatory Bowel Disease, Functional Bowel Disorder and Healthy Controls . Gastroenterology vol. 136 , ( 5 ) a - 262 .
Ng SC, Rigby R, Hart AL, Plamondon S, Gellatly N, McCarthy NE, Al-Hassi HO, Kamm MA et al. ( 2009 ) . P309 - Altered imprinting of lymphocyte homing by colonic dendritic cells in human ulcerative colitis . Journal of Crohn's and Colitis vol. 3 , ( 1 )
Ng SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ, Knight SC ( 2009 ) . P316 - TNF-α production and differential release of Th1/Th2 cytokines detected in colonic tissues of inflammatory bowel disease patients but not controls . Journal of Crohn's and Colitis vol. 3 , ( 1 ) s134 - s135 .
Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA, Knight SC ( 2008 ) . Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity . Clin Exp Allergy vol. 38 , ( 7 ) 1148 - 1159 .
Ng SC, Koutsoumpas A, Hedin CR, McCarthy NE, Plamondon S, Kamm MA, Knight SC, Forbes A et al. ( 2008 ) . W1201 Production of IL-10 By Colonic Dendritic Cells Is Associated with Higher Concentrations of Faecal Microbiota in Patients with Active Crohn's Disease . Gastroenterology vol. 134 , ( 4 )
Ng SC, Koutsoumpas A, Hedin CRH, McCarthy N, Plamondon S, Kamm MA, Knight SC, Forbes A et al. ( 2008 ) . P302 PRODUCTION OF IL-10 BY COLONIC DENDRITIC CELLS IS ASSOCIATED WITH HIGHER CONCENTRATIONS OF FAECAL MICROBIOTA IN PATIENTS WITH ACTIVE CROHN'S DISEASE . Journal of Crohn's and Colitis vol. 2 , ( 1 )
McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM et al. ( 2007 ) . Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma . Clin Exp Allergy vol. 37 , ( 1 ) 72 - 82 .