Publications: Dr Neil McCarthy

Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Stagg AJ, Lindsay JO, Whelan K ( 2021 ) . Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel disease . Clinical Nutrition vol. 40 , ( 8 ) 5009 - 5019 .

Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS et al. ( 2021 ) . Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis . Atherosclerosis vol. 324 , 58 - 68 .

Panoskaltsis N, McCarthy NE, Stagg AJ, Mummery CJ, Husni M, Arebi N, Greenstein D, Price CL et al. ( 2021 ) . Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm . Cancer Immunology, Immunotherapy vol. 70 , ( 4 ) 1127 - 1142 .

Panoskaltsis N, McCarthy NE, Knight SC ( 2021 ) . Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm . Cancer Immunol Immunother vol. 70 , ( 4 ) 1155 - 1160 .

McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC, Panoskaltsis N ( 2020 ) . Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells . Cancer Immunology Immunotherapy

Tse SW, Tan CF, Park JE, Gnanasekaran J, Gupta N, Low JK, Yeoh KW, Chng WJ et al. ( 2020 ) . Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles . Cancers (Basel) vol. 12 , ( 10 )

Ng SS, Park JE, Meng W, Chen CP, Kalaria RN, Mccarthy NE, Sze SK ( 2020 ) . Pulsed SILAM Reveals in Vivo Dynamics of Murine Brain Protein Translation . ACS Omega vol. 5 , ( 23 ) 13528 - 13540 .

Gill US, McCarthy NE ( 2019 ) . CD4 T cells in hepatitis B virus: "You don't have to be cytotoxic to work here and help" . Journal of Hepatology

Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N, Sze SK ( 2019 ) . ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer . Oncotarget vol. 10 , ( 57 ) 5970 - 5982 .

Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H et al. ( 2019 ) . Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial . Gastroenterology

Hoti I, McCarthy N, Giles E, Ayada I, Harrow P, Gordon H, Stagg A, Lindsay J ( 2019 ) . P092 Circulating classical monocytes and intestinal macrophages exhibit reduced response to IL-10 in IBD . Journal of Crohn's and Colitis . vol. 13 , s131 - s132 .

Cox S, Stagg A, Fromentin S, Ehrlich D, McCarthy N, Galleron N, Levenez F, Lomer M et al. ( 2018 ) . ADWE-09 Low fodmap diet improves functional-like gastrointestinal symptoms but reduces bifidobacteria in quiescent inflammatory bowel disease . Gut . vol. 67 ,

McCarthy NE, Eberl M ( 2018 ) . Human γδ T-Cell Control of Mucosal Immunity and Inflammation . Front Immunol vol. 9 , 985 - 985 .

MCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B, Eberl M ( 2017 ) . Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin . Journal of Immunology

McCarthy N, Gordon H, Rahman S, Harrow P, Stagg A, Lindsay J ( 2017 ) . P059 Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's disease . J Crohns Colitis . vol. 11 ,

Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, Macdonald TT, Lindsay JO, Stagg AJ ( 2017 ) . Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease . Mucosal Immunology vol. 10 , ( 1 ) 184 - 193 .

Petty RD, McCarthy NE, Dieu RL, Kerr JR ( 2016 ) . MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential diagnostic biomarkers in natural killer (NK) cells of patients with Chronic Fatigue Syndrome (CFS)/myalgic encephalomyelitis (ME) . PLoS ONE vol. 11 , ( 3 )

McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM et al. ( 2015 ) . Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease . Journal of Clinical Investigation vol. 125 , ( 8 ) 3215 - 3225 .

Brugha R, Mushtaq N, McCarthy NE, Stagg AJ, Grigg J ( 2015 ) . Respiratory tract dendritic cells in paediatric asthma . Clin Exp Allergy vol. 45 , ( 3 ) 624 - 631 .

Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO, Stagg AJ ( 2014 ) . Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease . Gastroenterology vol. 146 , ( 5 )

Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T et al. ( 2014 ) . Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings . Gut

McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al. ( 2013 ) . Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells . J Immunol vol. 191 , ( 5 ) 2752 - 2763 .

Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J et al. ( 2012 ) . Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease . Clin Exp Immunol vol. 170 , ( 2 ) 122 - 130 .

Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA et al. ( 2012 ) . Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment . Inflamm Bowel Dis vol. 18 , ( 7 ) 1275 - 1286 .

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG et al. ( 2012 ) . Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota . INFLAMMATORY BOWEL DISEASES vol. 18 , ( 6 ) 1092 - 1100 .

Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al. ( 2011 ) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease . Inflamm Bowel Dis vol. 17 , ( 10 ) 2027 - 2037 .

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD et al. ( 2011 ) . Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease . Gut vol. 60 , ( 7 ) 923 - 929 .

Ng SC, Benjamin JL, McCarthy NE, Hedin CR, Koutsoumpas A, Plamondon S, Price CL, Hart AL et al. ( 2010 ) . Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease . Inflamm Bowel Dis .

Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA, Knight SC ( 2008 ) . Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity . Clin Exp Allergy vol. 38 , ( 7 ) 1148 - 1159 .

McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM et al. ( 2007 ) . Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma . Clin Exp Allergy vol. 37 , ( 1 ) 72 - 82 .