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Research

Publications: Dr Stuart McDonald

Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A et al. ( 2020 ) . Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis . Nature Cancer976 - 989 .
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al. ( 2020 ) . 450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM . Gastroenterology vol. 158 , ( 6 ) s - 1276 .
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al. ( 2020 ) . CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM . GASTROENTEROLOGY . vol. 158 , S1276 - S1276 .
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Passman A, Williams M, Carlotti E, Cereser B, Hoare M, Russo F, Kocher HM, Chin-Aleong J et al. ( 2019 ) . The Cell of Origin of Normal Human Hepatocytes has a Common Ancestor with Biliary Epithelium and Hepatocyte Clonal Expansions Arise from the Portal Tract and Drift to the Central Vein . JOURNAL OF PATHOLOGY . vol. 249 , S16 - S16 .
Baker AM, Cross W, Curtius K, Al Bakir I, Choi CHR, Davis HL, Temko D, Biswas S et al. ( 2019 ) . Evolutionary history of human colitis-associated colorectal cancer . Gut vol. 68 , ( 6 ) 985 - 995 .
Zeki S, Hackett R, Dunn J, Bancil A, Preston S, Chin-Aleong J, Brown J, McDonald S ( 2019 ) . PTU-105 Automated, algorithm based extraction of Barrett’s surveillance metrics from natural language text is reliable . Gut . vol. 68 ,
Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al. ( 2019 ) . Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon . Cell Rep vol. 27 , ( 8 ) 2524 - 2524 .
Baker AM, Gabbutt C, Williams MJ, Cereser B, Jawad N, Rodriguez-Justo M, Jansen M, Barnes CP et al. ( 2019 ) . Crypt fusion as a homeostatic mechanism in the human colon . Gut vol. 68 , ( 11 ) 1986 - 1993 .
Su T, Grady J, Afshar S, MCDONALD SAC, Taylor R, Douglass T, Greaves L ( 2018 ) . Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations . Journal of Pathology vol. 246 , ( 4 ) 427 - 432 .
Cereser B, Jansen M, Austin E, Elia G, McFarlane T, van Deurzen CHM, Sieuwerts AM, Daidone MG et al. ( 2018 ) . Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells . Journal of Pathology vol. 244 , ( 1 ) 61 - 70 .
Walther V, Davis H, Owusu CK, Sivaharan A, Williams M, Rodriguez-Justo M, Jansen M, Leedham S et al. ( 2017 ) . CLONAL INTERACTIONS AS MECHANISMS OF POLYCLONALITY IN COLORECTAL ADENOMAS . GASTROENTEROLOGY . Conference: Digestive Disease Week vol. 152 , S153 - S153 .
Baker A-M, Davis CHRCH, Al-Bakir I, Martinez P, Temko D, Cross W, Williams M, Biswas S et al. ( 2017 ) . MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER . GASTROENTEROLOGY . Conference: Pathological Society vol. 152 , S983 - S984 .
Woodland PJ, Grassi F, Peiris M, Aktar R, Ooi JL, Evans J, Lee C, McDonald SA et al. ( 2017 ) . Sa1150 Innervation Pattern of the Distal Mucosal Squamous Epithelium May Underlie Hyposensitivity to Acid Reflux in Patients with Barrett’s Oesophagus . Gastroenterology . vol. 152 ,
Lavery DL, Baker AM, Van der Wel MJ, McDonald SAC, Quirke P, Novelli MR, Rodriguez-Justo M, Treanor D et al. ( 2017 ) . Adaptive Clonal Heterogeneity During Oesophageal Cancer Progression . JOURNAL OF PATHOLOGY . Conference: Pathological Society vol. 243 , S11 - S11 .
McDonald SA ( 2016 ) . Somatic Evolution of Barrett's/Oesophageal Cancer . JOURNAL OF PATHOLOGY . vol. 240 , 8 - 8 .
Evans JA, McDonald SAC ( 2016 ) . The complex, clonal, and controversial nature of barrett’s esophagus . Advances in Experimental Medicine and Biology vol. 908 , 27 - 40 .
Lavery DL, Martinez P, Gay LJ, Cereser B, Novelli MR, Rodriguez-Justo M, Meijer SL, Graham TA et al. ( 2016 ) . Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus . Gut vol. 65 , ( 6 ) 907 - 913 .
Alison M, Cereser B, Kocher H, McDonald SA ( 2015 ) . Clonal analysis of the human liver reveals adaptable stem cell dynamics . HEPATOLOGY . vol. 62 , 260A - 260A .
Jansen M, McDonald SA, Lavery D, Wright NA, Martinez P, Graham TA, Gay LJ ( 2015 ) . Spatial Sampling in Barrett's Oesophagus Shows Clonal Evolution of Oesophageal Adenocarcinoma from Metaplastic Non-Goblet Columnar Epithelium . JOURNAL OF PATHOLOGY . vol. 237 , S21 - S21 .
Jawad N, Johnson C, Butterworth E, Saeed I, Feakins R, Rodriguez-Justo M, McDonald S, Wright N et al. ( 2015 ) . OC-012 Do inflammatory polyps show features associated with the early stages of malignant progression? . Gut . vol. 64 ,
McDonald SAC, Lavery D, Wright NA, Jansen M ( 2015 ) . Barrett oesophagus: lessons on its origins from the lesion itself . Nat Rev Gastroenterol Hepatol vol. 12 , ( 1 ) 50 - 60 .
Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MRL, Scudamore CL, Cereser B, Crnogorac-Jurcevic T et al. ( 2015 ) . Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread . Cancer Cell vol. 27 , ( 1 ) 123 - 137 .
Wong P-P, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford M, Scudamore C, Cereser B, Crnogorac-Jurcevic T et al. ( 2015 ) . NOVEL DUAL-ACTION COMBINATION THERAPY ENHANCES ANGIOGENESIS WHILST REDUCING TUMOR GROWTH AND SPREAD . JOURNAL OF VASCULAR RESEARCH . vol. 52 , 6 - 6 .
McDonald SAC, Lavery D, Wright NA, Jansen M ( 2015 ) . Opinion : Barrett oesophagus: Lessons on its origins from the lesion itself . Nature Reviews Gastroenterology and Hepatology vol. 12 , ( 1 ) 50 - 60 .
McDonald SAC, Graham TA, Lavery DL, Wright NA, Jansen M ( 2015 ) . The Barrett's Gland in Phenotype Space . Cellular and Molecular Gastroenterology and Hepatology vol. 1 , ( 1 ) 41 - 54 .
Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS et al. ( 2014 ) . The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands . Gut vol. 63 , ( 12 ) 1854 - 1863 .
Baker A-M, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G et al. ( 2014 ) . Quantification of crypt and stem cell evolution in the normal and neoplastic human colon . Cell Rep vol. 8 , ( 4 ) 940 - 947 .
Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE et al. ( 2014 ) . Cell migration leads to spatially distinct but clonally related airway cancer precursors . Thorax vol. 69 , ( 6 ) 548 - 557 .
Jawad N, Crook J, Baker AM, Cereser B, Rodriguez-Justo M, Graham T, Wright N, McDonald S ( 2014 ) . PWE-086 Determining Stem Cell And Crypt Dynamics In Inflammatory Bowel Disease . Gut . vol. 63 Suppl 1 , A161 - A162 .
Zeki SS, Haidry R, Justo-Rodriguez M, Lovat LB, Wright NA, McDonald SA ( 2014 ) . Squamous cell carcinoma after radiofrequency ablation for Barrett's dysplasia . World J Gastroenterol vol. 20 , ( 15 ) 4453 - 4456 .
Jawad N, Graham TA, McDonald SAC, Wright NA ( 2014 ) . Re: Mitochondria and tumor progression in ulcerative colitis . J Natl Cancer Inst vol. 106 , ( 2 )
Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE et al. ( 2014 ) . Cell migration leads to spatially distinct but clonally related airway cancer precursors . Thorax vol. 69 , ( 6 ) 548 - 557 .
Teixeira V, Nadarajan P, Graham TA, Pipinikas CP, Brown JM, Falzon M, Nye E, Poulsom R et al. ( 2013 ) . LINEAGE TRACING IN HUMANS REVEALS STOCHASTIC HOMEOSTASIS OF AIRWAY EPITHELIUM RESULTING FROM NEUTRAL COMPETITION OF BASAL CELL PROGENITORS . THORAX . vol. 68 , A68 - A68 .
Teixera VH, Nadarajan P, Graham TA, Pipinikas CP, Brown TM, Falzon M, Nye E, Poulsom RP et al. ( 2013 ) . Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors . eLife vol. 2 , ( 22 ) e00966 - e00966 .
Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA et al. ( 2013 ) . Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation . American Journal of Gastroenterology vol. 108 , ( 10 ) 1584 - 1592 .
Zeki SS, Haidry R, Graham TA, Rodriguez-Justo M, Novelli M, Hoare J, Dunn J, Wright NA et al. ( 2013 ) . Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation . Am J Gastroenterol vol. 108 , ( 10 ) 1584 - 1592 .
Gabriel JP, Komuta M, Roskams T, Wright NA, McDonald SA, Alison MR ( 2013 ) . Comparison of the Histogenesis of Regenerative Nodules in Patients with Cirrhosis of Different Aetiologies . JOURNAL OF PATHOLOGY . vol. 231 , 17 - 17 .
Khan S, McDonald SAC, Wright NA, Graham TA, Odze RD, Rodriguez-Justo M, Zeki S ( 2013 ) . Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells . JOURNAL OF PATHOLOGY vol. 231 , ( 1 ) 98 - 104 .
Gabriel J, Graham TA, Kocher H, Wright NA, Alison M, McDonald SAC ( 2013 ) . Methylation Patterns of Clonally-Related Hepatocytes Provide Evidence of a Periportal Stem Cell Niche in the Normal Human Liver . JOURNAL OF PATHOLOGY . vol. 231 , 15 - 15 .
Humphries A, Cereser B, Gay LJ, Miller DSJ, Das B, Gutteridge A, Elia G, Nye E et al. ( 2013 ) . Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution . Proc Natl Acad Sci U S A vol. 110 , ( 27 ) E2490 - E2499 .
Lavery D, Nicholson A, Jeffery R, Poulsom R, Barr H, Jankowski J, Novelli M, Shepherd N et al. ( 2013 ) . BARRETT'S EPITHELIUM SHOWS EVIDENCE OF GASTRIC AND INTESTINAL DIFFERENTIATION PROGRAMMES BUT PRESERVES THE PROLIFERATIVE AND STEM CELL ARCHITECTURE OF GASTRIC GLANDS . GUT . vol. 62 , A13 - A13 .
Khan S, McDonald S, Wright NA, Robert OD, Rodriguez-Justo M, Graham TA, Zeki S ( 2013 ) . CRYPT CELL DYSPLASIA WITH MATURATION IN BARRETT'S ESOPHAGUS SHOWS CLONAL IDENTITY BETWEEN THE CRYPT AND SURFACE CELLS . GUT . vol. 62 , A198 - A199 .
Cereser B, Baker A-MC, Tadrous PJ, Humphries A, Novelli M, Rodriguez-Justo M, Graham TA, McDonald SA et al. ( 2013 ) . TWO DIMENSIONAL MAPPING OF MUTANT CLONES IN HUMAN COLONIC CRYPTS REVEAL STEM CELL DYNAMICS AND MIGRATION PATTERNS . GUT . vol. 62 , A194 - A195 .
Zeki SS, Lovat L, Haidry RJ, Wright NA, McDonald SA ( 2013 ) . Senescent Barrett's Epithelium Causes Proliferation of Neighbouring Non Senescent Epithelium by Paracrine Signalling . GASTROENTEROLOGY . vol. 144 , S676 - S677 .
Wright NA, Khan S, McDonald SAC, Galandiuk S, Graham TA, Odze RD, Rodriguez-Justo M, Zeki S ( 2013 ) . Crypt Cell Dysplasia with Maturation in Barrett's Esophagus Shows Clonal Identity between the Crypt and Surface Cells . JOURNAL OF PATHOLOGY . vol. 229 , S6 - S6 .
Lavery D, Nicholson A, McDonald SAC, Jeffrey R, Jansen M, Wright NA ( 2013 ) . Have We Got it Wrong about Barrett's Esophagus? Patterns of Gene Expression and Stem Cell Organisation Show Barrett's Glands to be a Unique Phenotype . JOURNAL OF PATHOLOGY . vol. 229 , S18 - S18 .
Pan Q, Nicholson AM, Barr H, Harrison LA, Wilson GD, Burkert J, Jeffery R, Alison MR et al. ( 2013 ) . Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus . Gastroenterology vol. 144 , ( 4 ) 761 - 770 .
Humphries A, Cereser B, Novelli M, Justo MR, Graham T, McDonald SAC, Wright NA ( 2012 ) . Human Colorectal Adenoma Growth is Characterised by Periods of Quiesence and Rapid Clonal Expansion . JOURNAL OF PATHOLOGY . vol. 228 , S16 - S16 .
Zeki S, Haidry R, Barr H, Shepherd N, Novelli M, Justo MR, Wright N, Lovat L et al. ( 2012 ) . Recurrence After Radiofrequency Ablation for Barrett's Related High Grade Dysplasia is Due to Persistence of Epithelial Mutations . JOURNAL OF PATHOLOGY . vol. 228 , S6 - S6 .
Jawad N, Graham T, Novelli M, Rodriguez-Justo M, Feakins R, Silver A, Wright N, McDonald S ( 2012 ) . ARE PSEUDOPOLYPS THE SOURCE OF TUMORIGENIC MUTATIONS IN ULCERATIVE COLITIS? . GUT vol. 61 , A236 - A236 .
Humphries A, Graham TA, Cereser B, McDonald SA, Wright NA ( 2012 ) . HUMAN COLORECTAL ADENOMA GROWTH IS CHARACTERISED BY PERIODS OF QUIESCENCE AND RAPID CLONAL EXPANSION . GUT vol. 61 , A7 - A8 .
Garcia TV, Rodriguez-Justo M, Graham T, Novelli M, Wright N, McDonald S ( 2012 ) . THE CLONAL ORIGINS OF GASTRIC ADENOCARCINOMA . GUT vol. 61 , A43 - A44 .
Khan S, Zeki S, Mitchell I, Harrison R, Dunn L, Leedham S, Barr H, Shepherd N et al. ( 2012 ) . THE CLONAL PROGRESSION OF BARRETT'S OESOPHAGUS TO OESOPHAGEAL ADENOCARCINOMA . GUT vol. 61 , A36 - A37 .
Zeki SS, Khan S, Graham TA, Leedham S, Barr H, Shepherd NA, Novelli M, Rodriguez-Justo M et al. ( 2012 ) . Barretts Related Adenocarcinomas Arise as a Monoclonal Outgrowth From Polyclonal Dysplasia . GASTROENTEROLOGY . vol. 142 , S643 - S644 .
Zeki SS, Haidry RJ, McDonald SA, Graham TA, Barr H, Shepherd NA, Novelli M, Rodriguez-Justo M et al. ( 2012 ) . Recurrence After Radiofrequency Ablation for Barretts Related High Grade Dysplasia is Due to Persistence of Epithelial Mutations . GASTROENTEROLOGY . vol. 142 , S750 - S750 .
Garcia TV, Rodriguez-Justo M, Graham TA, Novelli M, Wright NA, McDonald SA ( 2012 ) . The Clonal Origins of Gastric Adenocarcinoma . GASTROENTEROLOGY . vol. 142 , S643 - S643 .
McDonald S ( 2012 ) . Bullying at Barts . Lancet vol. 379 , ( 9825 )
Galandiuk S, Rodriguez-Justo M, Jeffery R, Nicholson AM, Cheng Y, Oukrif D, Elia G, Leedham SJ et al. ( 2012 ) . Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis . Gastroenterology vol. 142 , ( 4 ) 855 - 864.e8 .
Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R et al. ( 2012 ) . Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor . Gut vol. 61 , ( 10 ) 1380 - 1389 .
McDonald S ( 2012 ) . Reply: Bullying at Barts . The Lancet vol. 379 , ( 9825 )
Zeki S, Graham TA, McDonald SAC ( 2012 ) . Utilizing DNA mutations to trace epithelial cell lineages in human tissues . Methods Mol Biol vol. 916 , 289 - 301 .
Zeki SS, McDonald SA, Graham TA ( 2011 ) . Field cancerization in Barrett's esophagus . Discov Med vol. 12 , ( 66 ) 371 - 379 .
Gaisa NT, Graham TA, McDonald SA, Poulsom R, Heidenreich A, Jakse G, Knuechel R, Wright NA ( 2011 ) . Clonal architecture of human prostatic epithelium in benign and malignant conditions . J Pathol vol. 225 , ( 2 ) 172 - 180 .
Gaisa NT, Graham TA, McDonald SAC, Cañadillas-Lopez S, Poulsom R, Heidenreich A, Jakse G, Tadrous PJ et al. ( 2011 ) . The human urothelium consists of multiple clonal units, each maintained by a stem cell . J Pathol vol. 225 , ( 2 ) 163 - 171 .
Graham TA, McDonald SA, Wright NA ( 2011 ) . Field cancerization in the GI tract . Future Oncol vol. 7 , ( 8 ) 981 - 993 .
Humphries A, Graham TA, Nicholson AM, McDonald SA, Wright NA ( 2011 ) . Altered Stem Cell Dynamics in Human Colon Adenoma Crypts Allow Rapid Expansion and Fixation of Mutations During Clonal Expansion . GASTROENTEROLOGY . vol. 140 , S13 - S13 .
Graham TA, McDonald SA, Humphries A, Wright NA ( 2011 ) . The Life-Cycle of Human Colon Crypts . Gastroenterology vol. 140 , ( 5 ) s - 15 .
Humphries A, Graham T, McDonald S, Wright N ( 2011 ) . Altered stem cell dynamics in human colon adenoma crypts allow rapid expansion and fixation of mutations during clonal expansion . Gut . vol. 60 ,
Dunn JM, McDonald SA, Oukrif D, Haidry RJ, Butt MA, Lovat E, Lovat LB, Williams GH et al. ( 2011 ) . PLK-1 IS UPREGULATED IN BARRETT'S ADENOCARCINOMA AND IS A SURROGATE MARKER OF ANEUPLOIDY . GUT . vol. 60 ,
Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Leedham SJ, Novelli MR, Gay LJ, Ventayol-Garcia T, Green A et al. ( 2011 ) . The clonal origins of dysplasia from intestinal metaplasia in the human stomach . Gastroenterology vol. 140 , ( 4 )
Graham TA, Humphries A, Sanders T, Rodriguez-Justo M, Tadrous PJ, Preston SL, Novelli MR, Leedham SJ et al. ( 2011 ) . Use of methylation patterns to determine expansion of stem cell clones in human colon tissue . Gastroenterology vol. 140 , ( 4 )
Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R et al. ( 2011 ) . Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor . Gut
Humphries A, Graham TA, McDonald SAC ( 2011 ) . Stem cells and inflammation in the intestine . Recent Results Cancer Res vol. 185 , 51 - 63 .
Nicholson A, Graham T, Simpson A, Humphries A, Wright N, McDonald S, Jankowski J ( 2010 ) . Analysis of the Clonality of Barrett's Oesophagus Glands Reveals They are Clonal Units and Establishes a Common Stem Cell for Glandular and Squamous Epithelium . JOURNAL OF PATHOLOGY . vol. 222 , S17 - S18 .
Graham T, Galandiuk S, McDonald S, Leedham S, Wright N ( 2010 ) . Field Cancerization in Crohn's Disease . JOURNAL OF PATHOLOGY . vol. 222 , S15 - S16 .
Graham T, Khan S, Oukrif D, Green A, Jankowski J, Barr H, Novelli M, Shepherd N et al. ( 2010 ) . Investigating Clonal Dynamics in Barrett's Associated tumorigenesis Using Spatial Maps of Genetic Heterogeneity . JOURNAL OF PATHOLOGY . vol. 222 , S9 - S9 .
Nicholson A, Harrison L, Barr H, Graham T, McDonald S, Wright N, Harrison R, Jankowski J ( 2010 ) . Pulse Chase Experiments Using IUdR Identifies Barrett's Label-Retaining Stem Cells . JOURNAL OF PATHOLOGY . vol. 222 , S16 - S16 .
McDonald S, Jeffery R, Humphries A, Leedham S, Graham T, Segditsas S, Lewis A, Nicholson A et al. ( 2010 ) . Stem Cell Location Throughout the Human Gastrointestinal Tract as Defined by LGR5 mRNA In Situ Hybridisation . JOURNAL OF PATHOLOGY . vol. 222 , S12 - S12 .
Gutierrez-Gonzalez L, Graham TA, Rodriguez-Justo M, Green A, Gay LJ, Ventayol-Garcia T, Novelli M, Hashemi M et al. ( 2010 ) . CLONAL ORIGINS OF DYSPLASIA FROM METAPLASIA IN THE HUMAN STOMACH . GUT . vol. 59 , A17 - A18 .
Thirlwell C, Will OCC, Domingo E, Graham TA, McDonald SAC, Oukrif D, Jeffrey R, Gorman M et al. ( 2010 ) . Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas . Gastroenterology vol. 138 , ( 4 ) 1441 - 1454.e7 .
Graham TA, McDonald SAC ( 2010 ) . Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why? . Biochem Soc Trans vol. 38 , ( 2 ) 374 - 379 .
Graham TA, Khan S, Green A, Oukrif D, Gay L, Barr H, Novelli M, Jankowski J et al. ( 2010 ) . INVESTIGATING CLONAL COMPETITION IN BARRETT'S ASSOCIATED TUMORIGENESIS USING SPATIAL MAPS OF GENETIC HETEROGENEITY . GUT . vol. 59 , A111 - A111 .
Nicholson AM, Graham TA, Simpson AI, Humphries A, Wright NA, McDonald SAC, Jankowski JA ( 2010 ) . PWE-085 Analysis of the clonality of Barrett's oesophagus glands reveals they are clonal and establishes a common stem cell for glandular and squamous epithelium . Gut . vol. 59 ,
Lin W-R, Lim S-N, McDonald SAC, Graham T, Wright VL, Peplow CL, Humphries A, Kocher HM et al. ( 2010 ) . The histogenesis of regenerative nodules in human liver cirrhosis . Hepatology vol. 51 , ( 3 ) 1017 - 1026 .
Alison MR, McDonald SAC, Lin WR, Wright NA ( 2010 ) . Protection of Mitochondrial Genome Integrity: A New Stem Cell Property? . HEPATOLOGY vol. 51 , ( 1 ) 354 - 354 .
Preston S, Simpson A, Leedham S, McDonald S, Graham A, Graham T ( 2009 ) . Transatlantic Barrett's Esophagus: Are We Divided By More Than the 'O'? . AMERICAN JOURNAL OF GASTROENTEROLOGY . vol. 104 , S26 - S26 .
Alison MR, Fellous TG, McDonald SAC, Burkert J, Humphries A, Islam S, Gutierrez-Gonzalez L, Wright NA ( 2009 ) . ECM X: A methodological approach to tracing cell lineage in human tissues . European Cells and Materials vol. 18 , ( SUPPL. 1 )
McDonald SAC, Graham TA, Schier S, Wright NA, Alison MR ( 2009 ) . Stem cells and solid cancers . VIRCHOWS ARCH vol. 455 , ( 1 ) 1 - 13 .
Lanza R, Hogan B, Gaerhart J, Melton D, Pedersen R ( 2009 ) . Stem Cells in the Gastrointestinal Tract . Essentials of stem cell biology , Edition. 2nd , Academic Pr
Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM et al. ( 2009 ) . Locating the Stem Cell Niche and Tracing Hepatocyte Lineages in Human Liver . HEPATOLOGY vol. 49 , ( 5 ) 1655 - 1663 .
Humphries A, McDonald SA, Tadrous PJ, Wright NA ( 2009 ) . Mapping Stem Cell Clones in Human Intestinal Crypts . GASTROENTEROLOGY . vol. 136 , A78 - A79 .
Graham TA, Humphries A, McDonald SA, Leedham S, Wright NA ( 2009 ) . Methylation and Clonality of Human Colonic Crypts . GASTROENTEROLOGY . vol. 136 , A78 - A78 .
Gutierrez-Gonzalez L, Deheragoda M, Leedham SJ, Elia G, Shankar A, Imber C, Turnbull DM, Novelli M et al. ( 2009 ) . HUMAN SMALL INTESTINAL CRYPTS ARE CLONAL, CONTAIN MULTIPLE STEM CELLS AND MUTATED CRYPTS DIVIDE BY FISSION . GUT . vol. 58 , A2 - A2 .
Graham TA, Humphries A, Leedham SJ, McDonald SA, Wright NA ( 2009 ) . METHODS FOR TRACING CRYPT STEM CELLS ANCESTRY AND CLONAL ARCHITECTURE USING CPG ISLAND METHYLATION AND MITOCHONDRIAL DNA MUTATIONS . GUT . vol. 58 , A2 - A2 .
Gutierrez-Gonzalez L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Tumbull DM et al. ( 2009 ) . Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations . J PATHOL vol. 217 , ( 4 ) 489 - 496 .
Leedham SJ, Graham TA, Oukrif D, McDonald SAC, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR et al. ( 2009 ) . Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis-Associated Neoplasia . GASTROENTEROLOGY vol. 136 , ( 2 ) 542 - 550 .
Lovell M, Bhan C, Jankowski J, Mcdonald S ( 2009 ) . Molecular Biology of Gastroesophageal Cancers: The Role of Mutational Analysis in Prognosis . 21 - 30 .
Fellous TG, McDonald SAC, Burkert J, Humphries A, Islam S, De-Alwis NMW, Gutierrez-Gonzalez L, Tadrous PJ et al. ( 2009 ) . A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues . STEM CELLS vol. 27 , ( 6 ) 1410 - 1420 .
McDonald SAC, Graham TA, Humphries A, Wright NA, Preston SL, Brittan M, Direkze NC ( 2009 ) . Chapter 36 Stem Cells in the Gastrointestinal Tract . Essentials of Stem Cell Biology ,
Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, Sieber O, Santander S et al. ( 2008 ) . Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo . CANCER RES vol. 68 , ( 19 ) 7760 - 7768 .
Leedham SJ, Preston SL, McDonald SAC, Elia G, Bhandari P, Poller D, Harrison R, Novelli MR et al. ( 2008 ) . Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus . GUT vol. 57 , ( 8 ) 1041 - 1048 .
Mcdonald SAC, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY et al. ( 2008 ) . Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells . GASTROENTEROLOGY vol. 134 , ( 2 ) 500 - 510 .
Jankowski J, Sampliner R, Kerr D, Fong Y ( 2008 ) . Gastrointestinal Oncology: A Critical Multidisciplinary Approach: A Critical Multidisciplinary Team Approach . Molecular Biology of Gastroesophageal Cancers: the Role of Mutational Analysis in Prognosis , Wiley-Blackwell
McDonald SAC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Leedham SJ, Novelli M, Mitchell I, Stoker D, Jankowski JA et al. ( 2008 ) . The fixation of mutations and clonal expansion in intestinal metaplasia: Field cancerisation in the human stomach . GUT . vol. 57 , A32 - A32 .
Fellous TG, Britian M, Kocher H, Bhattacharya S, Tadrous PJ, Taylor GA, Greaves LC, Mcdonald SA et al. ( 2007 ) . Mitochondrial DNA mutations to investigate cell lineage relations in human liver . GASTROENTEROLOGY . vol. 132 , A830 - A830 .
Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M et al. ( 2007 ) . Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway . CANCER CELL vol. 11 , ( 4 ) 311 - 319 .
McDonald SAC, Leedham SJ, Greaves LC, Oulcrif D, Novelli MR, Deheragoda M, Turnbull DM, Jankowski JAZ et al. ( 2006 ) . Modelling of the expansion of normal human colonic crypts . JOURNAL OF PATHOLOGY . vol. 210 , 15 - 15 .
Leedham SJ, Maia LC, Seiber O, Preston SL, McDonald SAC, Tomlinson IPA, Novelli MR, Wright NA ( 2006 ) . The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different? . JOURNAL OF PATHOLOGY . vol. 210 , 54 - 54 .
Deheragoda MG, Leedham SJ, Brittan M, Direkze NC, Preston SL, Stoker DLS, Novelli MR, McDonald SAC et al. ( 2006 ) . The role of the periglandular myofbroblast sheath in gastric carcinogenesis . JOURNAL OF PATHOLOGY . vol. 210 , 12 - 12 .
McDonald SAC, Preston SL, Lovell MJ, Wright NA, Jankowski JAZ ( 2006 ) . Mechanisms of disease: from stem cells to colorectal cancer . NAT CLIN PRACT GASTR vol. 3 , ( 5 ) 267 - 274 .
McDonald SAC, Preston SL, Greaves LC, Leedham SJ, Lovell MA, Jankowski JAZ, Turnbull DM, Wright NA ( 2006 ) . Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way . CELL CYCLE vol. 5 , ( 8 ) 808 - 811 .
McDonald S, Atherfold PA, Obszynska J, Hardy RG, Sanders S, Harrison R, Rowan A, Tomlinson IP et al. ( 2006 ) . A CPG island within the P-cadherin promoter is hypomethylated early during colorectal tumourigenesis: Biological consequences . GASTROENTEROLOGY . vol. 130 , A716 - A716 .
Leedham SJ, Maia LC, Sieber O, Preston SL, McDonald SAC, Tomlinson IPM, Wright NA ( 2006 ) . Evidence of monoclonal origins in dysplasia in ulcerative colitis . GUT . vol. 55 , A16 - A16 .
McDonald SAC, Greaves LG, Leedham SJ, Yin-Lee C, Deheragoda M, Oukrif D, Novelli MR, Taylor RW et al. ( 2006 ) . Monoclonal conversion of human gastric glands provides insights into stem cell and clonal architecture . GUT . vol. 55 , A28 - A28 .
Leedham SJ, Deheragoda MG, Brittan M, Direkze NC, Preston SL, McDonald SAC, Wright NA ( 2006 ) . The stomach peri-glandular fibroblast sheath expands in inflamed tissue before development of intestinal metaplasia . GUT . vol. 55 , A30 - A30 .
Leedham SJ, Sieber O, Preston SL, McDonald SAC, Tomlinson IPM, Wright NA ( 2006 ) . Evidence of monoclonal origins in dysplasia in ulcerative colitis . JOURNAL OF PATHOLOGY . vol. 208 , 1A - 1A .
McDonald S, Greaves LG, Leedham SJ, Preston SL, Taylor RW, Oukrif D, Deheragoda M, Novelli MR et al. ( 2006 ) . Monoclonal conversion in human gastric glands: Insights into stem cell and clonal architecture . JOURNAL OF PATHOLOGY . vol. 208 , 29A - 29A .
Leedham SJ, Brittan M, Preston SL, McDonald SAC, Deheragoda M, Wright NA ( 2006 ) . The human and mouse gastric glands do possess a periglandular myofibroblastic sheath . JOURNAL OF PATHOLOGY . vol. 208 , 16A - 16A .
Leedham SJ, Brittan M, Preston SL, McDonald SAC, Wright NA ( 2006 ) . The stomach periglandular fibroblast sheath: all present and correct . Gut vol. 55 , ( 2 ) 295 - 296 .
Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M et al. ( 2006 ) . Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission . P NATL ACAD SCI USA vol. 103 , ( 3 ) 714 - 719 .
McDonald SAC, Graham T, Potten CS, Wright NA, Tomlinson IPM, Renehan AG ( 2006 ) . Intestinal stem cells and the development of colorectal neoplasia . Tissue Stem Cells ,
Leedham SJ, Brittan M, Preston SL, MCDONALD S, Wright NA ( 2006 ) . The stomach periglandular sheath: All present and correct . Gut vol. 55 , ( 2 ) 295 - 296 .
Potten CS, Clarke RB, Wilson J ( 2006 ) . Tissue stem cells . Informa HealthCare
Preston SL, McDonald SAC, Oukrif D, Greaves L, Turnbull D, Tadrous P, Sasieni P, Jankowski JA et al. ( 2005 ) . Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis . GUT . vol. 54 , A24 - A24 .
McDonald SAC, Preston SL, Greaves L, Tadrous P, Saseini P, Novelli M, Oukriff D, Jankowski J et al. ( 2005 ) . Clusters of phenotypically-related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis . JOURNAL OF PATHOLOGY . vol. 205 , 2 - 2 .
Leedham SJ, Brittan M, McDonald SAC, Wright NA ( 2005 ) . Intestinal stem cells . J Cell Mol Med vol. 9 , ( 1 ) 11 - 24 .
McDonald SAC, O'Grady JE, Bajaj-Elliott M, Notley CA, Alexander J, Brombacher F, McDonald V ( 2004 ) . Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines . JOURNAL OF INFECTIOUS DISEASES vol. 190 , ( 5 ) 1019 - 1025 .
Irving P, Lean S, Wood AJ, McDonald SA, Seward EM, Rampton DS ( 2004 ) . Poster presentations at national and international gastroenterology conferences are of limited value . GASTROENTEROLOGY . vol. 126 , A436 - A436 .
Lean IS, McDonald SAC, Bajaj-Elliott M, Pollok RCG, Farthing MJG, McDonald V ( 2003 ) . Interleukin-4 and transforming growth factor beta have opposing regulatory effects on gamma interferon-mediated inhibition of Cryptosporidium parvum reproduction . INFECT IMMUN vol. 71 , ( 8 ) 4580 - 4585 .
McDonald SAC, Bajaj-Elliott M, Smith PT, Ballinger AB, McDonald V ( 2003 ) . Immunity to Cryptosporidium parvum: A role for IL-4 in the early adaptive immune response . GUT . vol. 52 , A55 - A56 .
Lean IS, McDonald SAC, McDonald V ( 2003 ) . Tumour necrosis factor alpha mediates resistance to Cryptosporidium parvum infection in enterocyte cell lines but is not required for protection in a mouse model of infection . GUT . vol. 52 , A56 - A56 .
Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT ( 1999 ) . Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein . J Immunol vol. 162 , ( 1 ) 486 - 493 .
Higgins LM, McDonald SAC, Shields JG, Timans J, Whittle N, MacDonald TT ( 1998 ) . An OX40 fusion protein prevents colitis in mice . GASTROENTEROLOGY vol. 114 , ( 4 ) A995 - A995 .
Roy-Chaudhury P, Hillis G, MCDONALD S, Simpson JG, Power DA ( 1997 ) . Importance of the tubulointerstitium in human glomerulonephritis. II. Distribution of integrin chains beta 1, alpha 1 to 6 and alpha V . Kidney Int vol. 52 , ( 1 ) 103 - 110 .
McDonald SA, Palmen MJ, Van Rees EP, MacDonald TT ( 1997 ) . Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis . Immunology vol. 91 , ( 1 ) 73 - 80 .
Palmen MJHJ, McDonald SAC, vanRees EP, MacDonald TT ( 1996 ) . Non-lymphoid and lymphoid cells and their cytokine profiles in IL-2 knock-out mice . GASTROENTEROLOGY vol. 110 , ( 4 ) A986 - A986 .
Roy-Chaudhury P, Wu B, MCDONALD S, Haites NE, Simpson JG, Power DA ( 1995 ) . Phenotypic analysis of the glomerular and periglomerular mononuclear cell infiltrates in the Thy 1.1 model of glomerulonephritis . Lab Invest vol. 72 , ( 5 ) 524 - 531 .