Publications: Prof David Lee

Brookes O, Thorpe SD, Rigby Evans O, Keeling MC, Lee DA ( 2022 ) . Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells . Frontiers in Cell and Developmental Biology vol. 10 ,

Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD, del Río Hernández AE ( 2021 ) . G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization . Frontiers in Cell and Developmental Biology vol. 8 , 592628 - 592628 .

Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H et al. ( 2020 ) . GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA . Cancers vol. 12 , ( 2 )

Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D et al. ( 2020 ) . Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway . Nature Materials

Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, del Río Hernández AE ( 2019 ) . GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment . EMBO Reports vol. 20 , ( 1 )

Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K et al. ( 2019 ) . Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival . EMBO Reports vol. 20 , ( 1 )

Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L et al. ( 2018 ) . Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor . Oncogene

Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA et al. ( 2018 ) . RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells . Hepatology

Heywood HK, Thorpe SD, Jeropoulos RM, Lee DA ( 2017 ) . Small molecule activators of SIRT1 augment the regenerative potential of chondrocytes for cell-based cartilage repair techniques . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A14 - A14 .

Panesar KS, Thorpe SD, Lee DA ( 2017 ) . Uniaxial tensile strain modulates mesenchymal stem cell nuclear structure and histone methylation in a differentiation dependent manner . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A11 - A12 .

Elyasigomari V, Lee DA, Screen HRC, SHAHEED MH ( 2017 ) . Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification . Journal of Biomedical Informatics vol. 67 , ( 2017 ) 11 - 20 .

THORPE SD, Lee DA ( 2017 ) . Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity . Nucleus vol. 8 , ( 3 ) 287 - 300 .

Eraifej J, Thorpe SD, Martins RP, Lee DA ( 2017 ) . Does lamin A/C play a role in neuronal differentiation? . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A12 - A12 .

Thorpe SD, Oti A, Mauck RL, Lee DA ( 2017 ) . Stem cell differentiation state modulates Lamin AC localization and phosphorylation in response to cyclic tensile strain . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A13 - A14 .

Heywood HK, Caton PW, Lee DA ( 2016 ) . SIRT1, an enzyme vital to cartilage homeostasis, is regulated by osmolarity and glucose levels . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 97 , A2 - A2 .

Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA et al. ( 2016 ) . Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity . eLife vol. 5 ,

Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL, Chowdhury TT ( 2016 ) . Oxygen tension modulates the effects of TNFα in compressed chondrocytes . Inflamm Res

Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL ( 2016 ) . Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells . Biophysical Journal vol. 111 , ( 4 ) 864 - 874 .

Heywood HK, Lee DA ( 2016 ) . Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen . Journal of Tissue Engineering and Regenerative Medicine vol. 11 , ( 8 ) 2286 - 2294 .

Sliogeryte K, Botto L, Lee DA, Knight MM ( 2016 ) . Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion . Osteoarthritis and Cartilage vol. 24 , ( 5 ) 912 - 920 .

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT ( 2016 ) . Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility . J Invest Dermatol vol. 136 , ( 1 ) 74 - 83 .

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT ( 2016 ) . Type VI collagen regulates dermal matrix assembly and fibroblast motility . Journal of Investigative Dermatology vol. 136 , ( 1 ) 74 - 83 .

Heo SJ, Thorpe SD, Driscoll TP, Duncan RL, Lee DA, Mauck RL ( 2015 ) . Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells . Scientific Reports vol. 5 ,

Chen J, Bader DL, Lee DA, Knight MM ( 2015 ) . FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD . Journal of Mechanics in Medicine and Biology vol. 15 , ( 5 )

Tilwani RK, Lee DA, Pingguan-Murphy B, Abas WABW, Chowdhury TT ( 2014 ) . Hypoxia amplified catabolic effects induced by TNF alpha in chondrocytes - response reduced with biomechanical signals . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A33 - A34 .

Thorpe SD, Lee DA ( 2014 ) . Mesenchymal stem cell nuclear architecture is differentially regulated by lineage commitment and mechanical stimulation . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A33 - A33 .

Heywood HK, Lee DA ( 2014 ) . Reactive oxygen species drive the transformation to an oxidative energy metabolism in cultured articular chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 95 , A15 - A16 .

Irianto J, Lee DA, Knight MM ( 2014 ) . Quantification of chromatin condensation level by image processing . Med Eng Phys vol. 36 , ( 3 ) 412 - 417 .

Heywood HK, Nalesso G, Lee DA, Dell'accio F ( 2014 ) . Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture . Biores Open Access vol. 3 , ( 1 ) 9 - 18 .

Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM ( 2014 ) . Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics . Scientific Reports vol. 4 ,

Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA ( 2013 ) . Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes . Biophys J vol. 104 , ( 4 ) 759 - 769 .

Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD, Lee DA ( 2013 ) . Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells . TISSUE ENGINEERING PART C-METHODS vol. 19 , ( 1 )

Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM ( 2012 ) . Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment . Biophys J vol. 103 , ( 6 ) 1188 - 1197 .

Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM ( 2012 ) . Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study . J Mech Behav Biomed Mater vol. 11 , 72 - 81 .

Branford OA, Lee DA, Rolfe KJ, Grobbelaar AO ( 2012 ) . The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin . Journal of Hand Surgery: European Volume vol. 37 , ( 6 ) 564 - 572 .

Branford OA, Lee DA, Bader DL, Grobbelaar AO ( 2012 ) . The mechanics of flexor tendon adhesions . Journal of Hand Surgery: European Volume vol. 37 , ( 6 ) 555 - 563 .

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA ( 2012 ) . Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading . Biomechanics and Modeling in Mechanobiology vol. 11 , ( 3-4 ) 439 - 447 .

Martins RP, Finan JD, Guilak F, Lee DA ( 2012 ) . Mechanical regulation of nuclear structure and function . Annu Rev Biomed Eng vol. 14 , 431 - 455 .

Hosny NA, Lee DA, Knight MM ( 2012 ) . Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations . J Biomed Opt vol. 17 , ( 1 )

Pattappa G, Heywood HK, de Bruijn JD, Lee DA ( 2011 ) . The metabolism of human mesenchymal stem cells during proliferation and differentiation . J Cell Physiol vol. 226 , ( 10 ) 2562 - 2570 .

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC ( 2011 ) . Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment . Proc Inst Mech Eng H vol. 225 , ( 8 ) 821 - 830 .

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH, Screen HRC ( 2011 ) . Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment . P I MECH ENG H vol. 225 , ( H8 ) 821 - 830 .

Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al. ( 2011 ) . Electrospray deposited fibronectin retains the ability to promote cell adhesion . Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B , ( 1 ) 110 - 118 .

Chen J, Bader DL, Lee DA, Knight MM ( 2011 ) . Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression . 8TH INTERNATIONAL CONFERENCE ON CELL & STEM CELL ENGINEERING (ICCE) . vol. 30 , 17 - 20 .

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA ( 2011 ) . Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading . Biomechanics and Modeling in Mechanobiology1 - 9 .

Lee DA, Brand J, Salter D, Akanji O-O, Chowdhury TT ( 2011 ) . Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs . Methods Mol Biol vol. 695 , 77 - 97 .

Lee DA, Knight MM, Campbell JJ, Bader DL ( 2011 ) . Stem cell mechanobiology . J Cell Biochem vol. 112 , ( 1 ) 1 - 9 .

Pattappa G, Heywood HK, de Bruijn JD, Lee DA ( 2010 ) . The metabolism of human mesenchymal stem cells during proliferation and differentiation . J Cell Physiol

Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA ( 2010 ) . Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain . Connective Tissue Research vol. 51 , ( 6 ) 434 - 444 .

Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA et al. ( 2010 ) . Electrospray deposited fibronectin retains the ability to promote cell adhesion . Journal of Biomedical Materials Research Part B Applied Biomaterials vol. 96B , ( 1 ) 110 - 118 .

Heywood HK, Knight MM, Lee DA ( 2010 ) . Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates . Journal of Cellular Physiology vol. 223 , ( 3 ) 630 - 639 .

Ye S, Maeda E, Knight M, Lee D, Bader D, Wang W ( 2010 ) . A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles . The FASEB Journal vol. 24 , ( S1 ) 975.9 - 975.9 .

Hosny NA, Lee DA, Knight MM ( 2010 ) . Extracellular oxygen concentration mapping with confocal multiphoton laser scanning microscope and TCSPC card . MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES X . Editors: Periasamy, A, So, PTC, Konig, K , vol. 7569 ,

Heywood HK, Lee DA ( 2010 ) . Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes . J Cell Physiol vol. 222 , ( 1 ) 248 - 253 .

Maeda E, Shelton JC, Bader DL, Lee DA ( 2009 ) . Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles . Journal of Biomechanical Science and Engineering vol. 4 , ( 4 ) 510 - 517 .

Pattappa G, Jegard NC, Lee DA, de Bruijn JD ( 2009 ) . The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells . European Cells and Materials vol. 18 , ( SUPPL. 1 )

Mcleod R, Pattappa G, Irianto J, Awan M, Knight MM, Lee DA ( 2009 ) . Graded hydrogel constructs for cartilage tissue engineering . European Cells and Materials . vol. 18 ,

Campbell JJ, Maeda E, Ye SJ, Wang W, Lee DA ( 2009 ) . Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system . European Cells and Materials vol. 18 , ( SUPPL. 2 )

Pattappa G, Jegard NC, de Bruijn JD, Lee DA ( 2009 ) . The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells . European Cells and Materials vol. 18 , ( SUPPL. 2 )

Maeda E, Shelton JC, Bader DL, Lee DA ( 2009 ) . Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro . Journal of Applied Physiology vol. 106 , ( 2 ) 506 - 512 .

Berry CC, Shelton JC, Lee DA ( 2009 ) . Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs . J Tissue Eng Regen Med vol. 3 , ( 1 ) 43 - 53 .

Eniwumide JO, Lee DA, Bader DL ( 2009 ) . The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties . Biorheology vol. 46 , ( 5 ) 417 - 437 .

Heywood HK, Lee DA ( 2008 ) . Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes . Biochem Biophys Res Commun vol. 373 , ( 2 ) 224 - 229 .

Maeda E, Shelton JC, Bader DL, Lee DA ( 2008 ) . Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain . European Cells and Materials vol. 16 , ( SUPPL. 3 )

Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2008 ) . Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression . INFLAMM RES vol. 57 , ( 7 ) 306 - 313 .

Heywood HK, Lee DA ( 2008 ) . The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture . European Cells and Materials vol. 16 , ( SUPPL. 3 )

Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM, Lee DA ( 2008 ) . Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs . Arthritis Res Ther vol. 10 , ( 2 )

Chowdhury TT, Akanji OO, Salter DM, Bader DL, Lee DA ( 2008 ) . Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression . BIORHEOLOGY vol. 45 , ( 3-4 ) 257 - 274 .

Campbell JJ, Bader DL, Lee DA ( 2008 ) . Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells . J APPL BIOMATER BIOM vol. 6 , ( 1 ) 9 - 15 .

Akanji OO, Lee DA, Bader DA ( 2008 ) . The effects of direct current stimulation on isolated chondrocytes seeded in 3D agarose constructs . BIORHEOLOGY . vol. 45 , 229 - 243 .

Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL, Lee DA ( 2007 ) . 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION . Osteoarthritis and Cartilage vol. 15 , c42 - c43 .

Maeda E, Shelton JC, Bader DL, Lee DA ( 2007 ) . Time dependence of cyclic tensile strain on collagen production in tendon fascicles . BIOCHEM BIOPH RES CO vol. 362 , ( 2 ) 399 - 404 .

Bonzani IC, Knight MM, Lee DA, Bader DL, Williams A, Stevens MM ( 2007 ) . A model for studying the influence of mechanical loading on human periosteal stem cells . TISSUE ENGINEERING . vol. 13 , 1636 - 1636 .

Heywood HK, Lee DA ( 2007 ) . Development of an immunoassay for determination of adsorbed fibronectin levels on bio-functionalised substrates . TISSUE ENGINEERING . vol. 13 , 1669 - 1670 .

Chowdhury TT, Akanji OO, Arghandawi, Salter DM, Bader DL, Lee DA ( 2007 ) . Dynamic compression counteracts IL-1 beta b induced iNOS and COX-2 expression in chondrocytes cultured in agarose constructs . TISSUE ENGINEERING . vol. 13 , 1677 - 1677 .

Maeda E, Shelton JC, Bader DL, Lee DA ( 2007 ) . Gene expressions in tendon fascicles subjected to cyclic tensile strain . TISSUE ENGINEERING . vol. 13 , 1701 - 1701 .

Campbell JJ, Bader DL, Lee DA ( 2007 ) . Mechanical loading modulates calcium signalling within mesenchymal stem cells . TISSUE ENGINEERING . vol. 13 , 1722 - 1723 .

Pattappa G, De Bruijn JD, Lee DA ( 2007 ) . Mesenchymal stem cells maintain a glycolytic metabolism under normoxic conditions . TISSUE ENGINEERING . vol. 13 , 1725 - 1725 .

Mcleod R, Pattappa G, Irianto J, Knight MM, Lee DA ( 2007 ) . The development and characterisation of chondrocyte-seeded gradient hydrogel constructs for cartilage tissue engineering . TISSUE ENGINEERING . vol. 13 , 1763 - 1763 .

Heywood HK, Bader DL, Lee DA ( 2006 ) . Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs . Tissue Eng . vol. 12 , 3487 - 3496 .

Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC ( 2006 ) . The influence of swelling and matrix degradation on the microstructural integrity of tendon . Acta Biomater vol. 2 , ( 5 ) 505 - 513 .

Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL ( 2006 ) . Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields . BIOMECH MODEL MECHAN vol. 5 , ( 2-3 ) 180 - 191 .

Akanji OO, Bader DL, Lee DA ( 2006 ) . Direct current influences Ca ²⁺ signalling in chondrocytes . European Cells and Materials vol. 11 , ( SUPPL.2 )

Chowdhury TT, Appleby RN, Salter DM, Bader DA, Lee DA ( 2006 ) . Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes . Biomech Model Mechanobiol vol. 5 , ( 2-3 ) 192 - 201 .

Enobakhare B, Bader DL, Lee DA ( 2006 ) . Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering . J Appl Biomater Biomech vol. 4 , ( 2 ) 87 - 96 .

Heywood HK, Bader DL, Lee DA ( 2006 ) . Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration . Journal of Cellular Physiology vol. 206 , ( 2 ) 402 - 410 .

Chowdhury TT, Bader DL, Lee DA ( 2006 ) . Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes . Biochem Biophys Res Commun vol. 339 , ( 1 ) 241 - 247 .

Bader DL, Lee DA, Knight MM ( 2006 ) . Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2) . The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME vol. 2005.18 , ( 0 ) 2 - 3 .

Chowdhury TT, Bader DL, Lee DA ( 2006 ) . Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs . Biorheology vol. 43 , ( 3,4 ) 413 - 429 .

Campbell JJ, Lee DA, Bader DL ( 2006 ) . Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells . BIORHEOLOGY . vol. 43 , 455 - 470 .

Knight MM, Toyoda T, Lee DA, Bader DL ( 2006 ) . Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . J Biomech vol. 39 , ( 8 ) 1547 - 1551 .

Chowdhury TT, Raveenthiran SP, Bader DL, Lee DA ( 2006 ) . P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE . Osteoarthritis and Cartilage vol. 14 ,

Pingguan-Murphy B, Lee DA, Bader DL, Knight MM ( 2005 ) . Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles . Arch Biochem Biophys vol. 444 , ( 1 ) 45 - 51 .

Screen HRC, Bader DL, Shelton JC, Lee DA ( 2005 ) . Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 193 - 194 .

Pingguan B, Lee DA, Bader DL, Knight MM ( 2005 ) . Dynamic compression activates chondrocyte calcium signaling in a cycle dependent manner involving the release of ATP . Proceedings of the 2005 Summer Bioengineering Conference . vol. 2005 , 223 - 224 .

Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 251 - 252 .

Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW, Lee DA ( 2005 ) . Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 439 - 440 .

Chowdhury TT, Appleby RN, Salter DA, Bader DL, Lee DA ( 2005 ) . Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs . Proceedings of the 2005 Summer Bioengineering Conference vol. 2005 , 545 - 546 .

Bader DL, Lee DA ( 2005 ) . Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible? . 165 - 192 .

Screen HRC, Shelton JC, Bader DL, Lee DA ( 2005 ) . Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles . Biochem Biophys Res Commun vol. 336 , ( 2 ) 424 - 429 .

Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL ( 2005 ) . Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach . J Biomech Eng vol. 127 , ( 5 ) 758 - 766 .

Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA ( 2005 ) . The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles . Ann Biomed Eng vol. 33 , ( 8 ) 1090 - 1099 .

Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs . European Cells and Materials vol. 10 , ( SUPPL.2 )

Catuogno C, Chowdhury TT, Bader DL, Lee DA ( 2005 ) . Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs . European Cells and Materials vol. 10 , ( SUPPL.2 )

Pingguna B, Lee DA, Bader DL, Knight MM ( 2005 ) . Mechanical compression activates chondrocyte Calcium signalling in a cycle dependent Manner Involving the release of ATP . European Cells and Materials . vol. 10 ,

Eniwumide JO, Lee DA, Bader DL ( 2005 ) . Perfusion-Enhancement of molecular transport within 3D scaffolds . European Cells and Materials vol. 10 , ( SUPPL.2 )

Heywood HK, Bader DL, Lee DA ( 2005 ) . Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate . European Cells and Materials vol. 10 , ( SUPPL.2 )

Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S et al. ( 2005 ) . British society for matrix biology autumn meeting . International Journal of Experimental Pathology vol. 86 , ( 3 )

Sharma A, Bomzon Z, Lee DA, Kimmel E, Bader DL, Knight MM ( 2005 ) . Compression-induced reorganization of cytoplasmic networks in bovine chondrocytes using mitochondria as markers . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A34 - A34 .

Screen HRC, Shelton JC, Bader DL, Lee DA ( 2005 ) . Cyclic tensile strain upregulates collagen production in isolated tendon fascicles . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A8 - A9 .

Heywood HK, Bader DL, Lee DA ( 2005 ) . Glucose metabolism of chondrocytes in tissue-engineered alginate constructs . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A13 - A14 .

Appleby RN, Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2005 ) . Integrin-mediated mechanotransduction in IL-1 beta-stimulated chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A38 - A39 .

Baria KE, Bader DL, Screen HRC, Lee DA ( 2005 ) . The effect of substrate and medium composition on the response of human dermal fibroblasts to cyclic tensile strain in vitro . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 86 , A32 - A33 .

Rugg EL, Al-Rawi H, Lee D, McNeill AM ( 2005 ) . Trimethylamine N-oxide reduces the effects of osmotic stress in EBS keratinocytes . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 124 , A76 - A76 .

Goldberg AJ, Lee DA, Bader DL, Bentley G ( 2005 ) . Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture . J Bone Joint Surg Br vol. 87 , ( 1 ) 128 - 134 .

Wang Y-N, Bouten CVC, Lee DA, Bader DL ( 2005 ) . Compression-induced damage in a muscle cell model in vitro . Proc Inst Mech Eng H vol. 219 , ( 1 ) 1 - 12 .

Screen HRC, Bader DL, Lee DA, Shelton JC ( 2004 ) . Local strain measurement within tendon . STRAIN vol. 40 , ( 4 ) 157 - 163 .

Heywood HK, Sembi PK, Lee DA, Bader DL ( 2004 ) . Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs . Tissue Eng vol. 10 , ( 9-10 ) 1467 - 1479 .

Bryant SJ, Anseth KS, Lee DA, Bader DL ( 2004 ) . Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain . J Orthop Res vol. 22 , ( 5 ) 1143 - 1149 .

Lee DA, Knight MM ( 2004 ) . Mechanical Loading of Chondrocytes Embedded in 3D Constructs . Cartilage and Osteoarthritis , vol. 100 ,

Chowdhury TT, Salter DM, Bader DL, Lee DA ( 2004 ) . Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes . Biochem Biophys Res Commun vol. 318 , ( 4 ) 873 - 881 .

Bryant SJ, Chowdhury TT, Lee DA, Bader DL, Anseth KS ( 2004 ) . Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels . Ann Biomed Eng vol. 32 , ( 3 ) 407 - 417 .

Screen HRC, Lee DA, Bader DL, Shelton JC ( 2004 ) . An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties . Proc Inst Mech Eng H vol. 218 , ( 2 ) 109 - 119 .

Chowdhury TT, Bader DL, LEE DA ( 2004 ) . Combined anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated bovine chondrocytes cultured in agarose constructs . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 144 - 144 .

Knight MM, Hibbs K, Roberts SR, LEE DA, Bader DL ( 2004 ) . Cyclic preconditioning mediates chondrocytes calcium signaling in unstrained and compressed agarose constructs . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 829 - 829 .

Chowdhury TT, Bader DL, Lee DA ( 2004 ) . Dynamic compression counteracts IL-1 beta-induced iNOS and COX-2 activity in human chondrocytes cultured in agarose constructs . OSTEOARTHRITIS AND CARTILAGE . vol. 12 , S19 - S19 .

LEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J, Weinans H ( 2004 ) . Extracellular matrix influences the response of chondrocytes to dynamic compression . Trans. Orthop.Rev. Soc vol. 29 , 839 - 839 .

Heywood HK, Bader DL, Bongers M, LEE DA ( 2004 ) . Glucose depletion induces an upregulation of oxygen utilisation by chondrocytes . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 261 - 261 .

Knight MM, Bonzom Z, Sharma AM, LEE DA, Kimmel E, Bader DL ( 2004 ) . Heterogeneity of deformation of cytoplasmic networks in compressed chondrocytes . Trans. Orthops. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 544 - 544 .

Bader DL, KNIGHT MM, Bentley G, Kayser M, Holloway I ( 2004 ) . Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage . Osteoarthritis Cartilage vol. 12 , ( 1 ) 17 - 24 .

Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM ( 2004 ) . Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage . Osteoarthritis Cartilage vol. 12 , ( 1 ) 17 - 24 .

Chowdhury TT, Appleby RN, Salter DM, Bader DL, Lee DA ( 2004 ) . Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes . OSTEOARTHRITIS AND CARTILAGE . vol. 12 , S102 - S102 .

Lee DA, Knight MM ( 2004 ) . Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain . Methods Mol Med vol. 100 , 307 - 324 .

Heywood HK, DeRosa E, LEE DA, Bader DL, Netti P ( 2004 ) . Non-invasive monitoring of molecular diffusion in neo-cartilage using FRAP technique . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 531 - 531 .

Wiseman M, Bader DL, Reisler T, Lee DA ( 2004 ) . Passage in monolayer influences the response of chondrocytes to dynamic compression . Biorheology vol. 41 , ( 3-4 ) 283 - 298 .

Chowdhry TT, Salter DM, Bader DL, LEE DA ( 2004 ) . alpha 5 beta 1 integrin mediates mechanotransduction processes in TGF-beta stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression . Trans. Orthop. Res. Soc. . Conference: 50th Annual Meeting of the Orthopaedic Research Society vol. 29 , 338 - 338 .

Chowdhury TT, Bader DL, Lee DA ( 2003 ) . Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs . Osteoarthritis Cartilage vol. 11 , ( 9 ) 688 - 696 .

Chowdhury TT, Bader DL, Shelton JC, Lee DA ( 2003 ) . Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression . Arch Biochem Biophys vol. 417 , ( 1 ) 105 - 111 .

Berry CC, Shelton JC, Bader DL, Lee DA ( 2003 ) . Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels . Tissue Eng vol. 9 , ( 4 ) 613 - 624 .

Wiseman M, Henson F, Lee DA, Bader DL ( 2003 ) . Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface . Equine Vet J vol. 35 , ( 5 ) 451 - 456 .

Knight MM, Roberts SR, Lee DA, Bader DL ( 2003 ) . Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death . American Journal of Physiology - Cell Physiology . vol. 284 ,

Knight MM, Roberts SR, Lee DA, Bader DL ( 2003 ) . Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death . Am J Physiol Cell Physiol vol. 284 , ( 4 ) C1083 - C1089 .

Lee DA, Reisler T, Bader DL ( 2003 ) . Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques . Acta Orthop Scand vol. 74 , ( 1 ) 6 - 15 .

Chowdhury TT, Shelton JC, Bader DL, LEE DA ( 2003 ) . Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs . Internat. J. Artificial Organs vol. 26 , ( 9 ) 858 - 858 .

Berry CC, Cacou C, Lee DA, Bader DL, Shelton JC ( 2003 ) . Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner . Biorheology vol. 40 , ( 1-3 ) 337 - 345 .

Screen HRC, Lee DA, Bader DL, Shelton JC ( 2003 ) . Development of a technique to determine strains in tendons using the cell nuclei . Biorheology vol. 40 , ( 1-3 ) 361 - 368 .

LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ, Sengers BG ( 2003 ) . Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes . Internat. J. Artificial Organs vol. 26 , 875 - 875 .

Shelton JC, Bader DL, Lee DA ( 2003 ) . Mechanical conditioning influences the metabolic response of cell-seeded constructs . Cells Tissues Organs vol. 175 , ( 3 ) 140 - 150 .

SCREEN HRC, Shelton JC, Bader DL, Lee DA ( 2003 ) . The effects on non-collagenous matrix components on tendon fascicle micromechanics . Trans. Orthop. Res. Soc. . Conference: 49th Annual Meeting of the Orthopaedic Research Society vol. 28 , 806 - 806 .

Hernandez D, Addou S, Lee D, Orengo C, Shephard EA, Phillips IR ( 2003 ) . Trimethylaminuria and a human FMO3 mutation database . HUM MUTAT vol. 22 , ( 3 ) 209 - 213 .

Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL ( 2003 ) . alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression . Osteoarthritis Cartilage vol. 11 , ( Suppl 1 ) S2 - S3 .

Chowdhury TT, LEE DA, Salter DM, Shelton JC, Bader DL ( 2003 ) . alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta3-stimulated human chondrocytes seeded in agarose constructs and subjected to dynamic compression . Tissue Engineering . Conference: ETES vol. 9 , 792 - 792 .

Knight MM, Roberts SR, Lee DA, Bader DL ( 2002 ) . Light-induced calcium signalling in chondrocytes . European Cells and Materials . vol. 4 , 7 - 8 .

Knight MM, Toyoda T, Bader DL, Lee DA ( 2002 ) . Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products .

Lee DA ( 2002 ) . The design of bioreactor systems for cartilage tissue engineering . Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Berry CC, Shelton JC, Bader DL, Lee DA ( 2002 ) . The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels . Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Lee DA, Chowdhury TT, Roberts SR, Knight MM, Bader DL ( 2002 ) . An in vitro investigation of cartilage mechanotransduction . INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS . vol. 25 , 617 - 618 .

Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H, Bader DL ( 2002 ) . Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus . Biochim Biophys Acta vol. 1570 , ( 1 ) 1 - 8 .

Holloway I, Knight MM, LEE DA, Bader DL, Bentley G ( 2002 ) . Changes in cell morphology and cytoskeletal organisation in osteoarthritic cartilage . Eur Cell Mater . Conference: ECM III Cartilage & Joint repair Tutorials, Basic Research & Clinical Methods ( Davos, Switzerland ) from: 01/07/2002 to: 03/07/2002 , vol. 4 suppl 1 , 52 - 53 .

Holloway I, Knight MM, LEE DA, Bader DL, Bentley G ( 2002 ) . Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage . Trans. Orthop. Res. Soc . Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27 ,

Bader DL, Ohashi T, Knight MM, Lee DA, Sato M ( 2002 ) . Deformation properties of articular chondrocytes: a critique of three separate techniques . Biorheology . vol. 39 , 69 - 78 .

BADER DL, Shelton JC, Lee DA, Screen HRC ( 2002 ) . Development of a technique to determine strains in tendons using the cell nuclei . Biorheology vol. 40 , 361 - 368 .

Knight MM, Roberts SR, LEE DA, Bader DL ( 2002 ) . Light-induced calcium signalling in chondrocytes . Eur. Cells Materials . Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society ( University of Glasgow, Scotland ) from: 19/09/2002 to: 20/09/2002 , vol. 4 , 7 - 8 .

Knight MM, Toyoda T, LEE DA, Bader DL ( 2002 ) . Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . Trans. Orthop. Res. Soc. . Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27 , 35 - 35 .

Heywood HK, LEE DA, Bader DL ( 2002 ) . Monitoring neo-cartilage formation in cell seeded alginate constructs of clinically relevant dimensions . Eur. Cells Materials . Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society ( Glasgow, Scotland ) from: 19/09/2002 to: 20/09/2002 , vol. 4 suppl 2 , 1 - 2 .

Bader DL, Shelton JC, Lee DA, SCREEN HRC ( 2002 ) . Non-collagenous matrix components influence the micromechanical environment of tenocytes within tendon fascicles subjected to tensile strain . Eur. Cells Mat. vol. 4:S1 , 41 - 42 .

SCREEN HRC, Lee DA, Bader DL, Shelton JC ( 2002 ) . The strain behaviour of tendon under tensile load, using cell nuclei as strain markers . Trans. Orthop. Res. Soc. . Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27 , 604 - 604 .

Chowdhury TT, Bader DL, Lee DA ( 2001 ) . Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs . Biochem Biophys Res Commun vol. 285 , ( 5 ) 1168 - 1174 .

Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA ( 2001 ) . Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose . Biochim Biophys Acta vol. 1526 , ( 2 ) 141 - 146 .

Knight MM, Idowu BD, Lee DA, Bader DL ( 2001 ) . Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique . Med Biol Eng Comput vol. 39 , ( 3 ) 397 - 404 .

Roberts SR, Knight MM, Lee DA, Bader DL ( 2001 ) . Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs . J Appl Physiol (1985) vol. 90 , ( 4 ) 1385 - 1391 .

Bouten CV, Knight MM, Lee DA, Bade DL ( 2001 ) . Compressive deformation and damage of muscle cell subpopulations in a model system . Ann Biomed Eng vol. 29 , ( 2 ) 153 - 163 .

Bader DL, KNIGHT MM, Lee DA, Bouten CV ( 2001 ) . Compressive deformation and damage of muscle cell subpopulaltions in a model system . Ann. Biomed. Eng. vol. 29 , ( 2 ) 153 - 163 .

Chowdhury T, Bader DL, LEE DA ( 2001 ) . Dynamic compression influences the synthesis of nitric oxide by IL-1beta stimulated chondrocyte sub-populations cultured in agarose constructs . Trans. Orthop. Res. Soc . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 604 - 604 .

Lee DA ( 2001 ) . Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK . INTERDISCIPL SCI REV vol. 26 , ( 2 ) 112 - 124 .

LEE DA, Idowu BD, Knight MM, Bader DL ( 2001 ) . Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs . Trans. Orthop. Res. Soc. . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 263 - 263 .

Enobakhare B, Bader DL, LEE DA ( 2001 ) . Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs . Trans. Orthop. Res. Soc . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 638 - 638 .

Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL ( 2001 ) . Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds . Trans. Orthop. Res. Soc. . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 611 - 611 .

Berry CC, Cacou C, Shelton JC, Bader DL, Lee DA ( 2000 ) . Biological response of cyclic strain on developed cell seeded collagen gel model . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Knight MM, Van De Breevaart Bravenboer J, Bader DL, Lee DA ( 2000 ) . Compression induced cell and nucleus deformation in chondrocyte-alginate constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling .

Chowdhury TT, Bader DL, Lee DA ( 2000 ) . Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Roberts SR, Knight MM, Lee DA, Bader DL ( 2000 ) . Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling .

Enobakhare BO, Bader DL, Lee DA ( 2000 ) . Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling

Cacou C, Palmer D, Lee DA, Bader DL, Shelton JC ( 2000 ) . A system for monitoring the response of uniaxial strain on cell seeded collagen gels . MED ENG PHYS vol. 22 , ( 5 ) 327 - 333 .

Idowu BD, Knight MM, Bader DL, Lee DA ( 2000 ) . Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose . Histochem J vol. 32 , ( 3 ) 165 - 174 .

Roberts SR, Knight MM, Lee DA, Bader DL ( 2000 ) . Intracellular calcium signalling in compressed chondrocyte agarose constructs . J PHYSIOL-LONDON . vol. 523 , 12P - 12P .

Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL ( 2000 ) . Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels . J Biomech vol. 33 , ( 1 ) 81 - 95 .

Lee DA, Noguchi T, Frean SP, Lees P, Bader DL ( 2000 ) . The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs . Biorheology vol. 37 , ( 1-2 ) 149 - 161 .

Huang J, Hing KA, Best SM, Lee DA, Silvio LD, Bonfield W ( 1999 ) . A COMPARATIVE STUDY OF VARIOUS ASSAYS FOR IN VITRO BIOCOMPATIBILITY ASSESSMENT OF EXPERIMENTAL ZIRCONIA . Conference: Bioceramics199 - 202 .

White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB, Lee DA ( 1999 ) . The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage . KNEE vol. 6 , ( 3 ) 197 - 205 .

Knight MM, Ghori SA, Lee DA, Bader DL ( 1998 ) . Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression . Med Eng Phys vol. 20 , ( 9 ) 684 - 688 .

Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL ( 1998 ) . Response of chondrocyte subpopulations cultured within unloaded and loaded agarose . J Orthop Res vol. 16 , ( 6 ) 726 - 733 .

Knight MM, Lee DA, Bader DL ( 1998 ) . The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose . Biochim Biophys Acta vol. 1405 , ( 1-3 ) 67 - 77 .

Lee DA, Frean SP, Lees P, Bader DL ( 1998 ) . Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose . BIOCHEM BIOPH RES CO vol. 251 , ( 2 ) 580 - 585 .

Lee DA, Assoku E, Doyle V ( 1998 ) . A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation . J MATER SCI-MATER M vol. 9 , ( 1 ) 47 - 51 .

Lee DA, Bader DL ( 1997 ) . Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose . J ORTHOP RES vol. 15 , ( 2 ) 181 - 188 .

Enobakhare BO, Bader DL, Lee DA ( 1996 ) . Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue . ANAL BIOCHEM vol. 243 , ( 1 ) 189 - 191 .

Doyle V, Pearson R, Lee D, Wolowacz S, Mc Taggart S ( 1996 ) . An investigation of the growth of human dermal fibroblasts on poly-L-lactic acid in vitro . Journal of Materials Science: Materials in Medicine vol. 7 , ( 6 ) 381 - 385 .

Lee DA, Bader DL ( 1995 ) . The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes . IN VITRO CELL DEV-AN vol. 31 , ( 11 ) 828 - 835 .