Publications:  Prof Richard Leslie

Mishra R, Åkerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, Hodge KM, Guy VC et al.(2020). Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC. Diabetes Care vol. 43, (2) 418-425.

Ibrahim M, Baker J, Cahn A, Eckel RH, El Sayed NA, Fischl AH, Gaede P, Leslie RD et al.(2020). Hypoglycaemia and its management in primary care setting. Diabetes/Metabolism Research and Reviews

Leslie R, Vartak T(2019). Allostasis and the origins of adult-onset diabetes. Diabetologia vol. 63, (2) 261-265.

Leslie RD, Vartak T(2019). C-peptide persistence in type 1 diabetes: 'Not drowning, but waving'?. BMC Medicine vol. 17, (1)

Cardona A, Day FR, Perry JRB, Loh M, Chu AY, Lehne B, Paul DS, Lotta LA et al.(2019). Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study. Diabetes

Van Rampelbergh J, Boitard C, Achenbach P, Leslie RD, Dayan C, Keymeulen B, Owen KR, Lapauw B et al. (2019). Phase Ib clinical trial of IMCY-0098 in young adults with recent-onsent type 1 diabetes. DIABETOLOGIA. vol. 62, S352-S353.

Leslie RD, Jerram ST(2019). Looking back and looking forward: A brief history of research into type 1 diabetes. Diabetes - Metabolism: Research and Reviews vol. 35, (6)

Xiang Y, Huang G, Zhu Y, Zuo X, Liu X, Feng Q, Li X, Yang T et al.(2019). Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey. Diabetes, Obesity and Metabolism vol. 21, (4) 893-902.

Leslie RD, Grant SFA(2018). The Dynamic Origins of Type 1 Diabetes. Diabetes Care vol. 41, (12) 2441-2443.

Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, Davis A, Hodge KM et al. (2018). First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes. Diabetes Care. vol. 41, 2396-2403.

Mishra R, Bradfield JP, Cousminer DL, Chesi A, Hodge KM, Hakonarson H, Mauricio D, Schloot NC et al. (2018). Genetic discrimination between LADA and type 1 diabetes within the MHC. DIABETOLOGIA. vol. 61, S104-S105.

Niu X, Luo S, Li X, Xie Z, Xiang Y, Huang G, Lin J, Yang L et al.(2018). Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8. Diabetes - Metabolism: Research and Reviews vol. 35, (1) e3068-e3068.

Mishra R, Hodge KM, Cousminer DL, Leslie RD, Grant SFA(2018). A Global Perspective of Latent Autoimmune Diabetes in Adults. Trends in Endocrinology and Metabolism vol. 29, (9) 638-650.

Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK, Bonifacio E, Ziegler AG et al.(2018). Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12. Diabetologia vol. 61, (7) 1644-1649.

Ibrahim M, Tuomilehto J, Aschner P, Beseler L, Cahn A, Eckel RH, Fischl AH, Guthrie G et al.(2018). Global status of diabetes prevention and prospects for action: A consensus statement. Diabetes - Metabolism: Research and Reviews vol. 34, (6)

Pozzilli P, Leslie RD, Peters AL, Buzzetti R, Shankar SS, Milicevic Z, Pavo I, Lebrec J et al.(2018). Dulaglutide treatment results in effective glycaemic control in latent autoimmune diabetes in adults (LADA): A post-hoc analysis of the AWARD-2, -4 and -5 Trials. Diabetes, Obesity and Metabolism vol. 20, (6) 1490-1498.

Napoli N, Strollo R, Defeudis G, Leto G, Moretti C, Zampetti S, D'Onofrio L, Campagna G et al.(2018). Serum Sclerostin and Bone Turnover in Latent Autoimmune Diabetes in Adults. Journal of Clinical Endocrinology and Metabolism vol. 103, (5) 1921-1928.

Leslie RD, Lernmark Å(2018). Genetic risk scores in adult-onset type 1 diabetes. The Lancet Diabetes and Endocrinology vol. 6, (3) 168-169.

Leslie RD, Grant SFA(2018). Teasing Diabetes Apart, One Locus at a Time. Diabetes Care vol. 41, (2) 224-226.

Jerram ST, Dang MN, Leslie RD(2017). The Role of Epigenetics in Type 1 Diabetes. Current Diabetes Reports vol. 17, (10)

Toniolo A, Leslie RD(2017). Diabetes, the TYK2 Gene and the Interferon Response: In Search for Environmental Causes. EBioMedicine vol. 24, 18-19.

Pozzilli P, Leslie RD, Peters A, Buzzetti R, Shankar SS, Milicevic Z, Pavo I, Lebrec J et al. (2017). Reduction of HbA1c with dulaglutide in type 2 diabetes (T2D) patients negative, low positive or high positive for GAD antibodies (GADA): a post hoc analysis of AWARD-2,-4 and-5. DIABETOLOGIA. vol. 60, S68-S68.

Jerram ST, Leslie RD(2017). The Genetic Architecture of Type 1 Diabetes. Genes (Basel) vol. 8, (8)

Hernández M, López C, Real J, Valls J, Ortega-Martinez de Victoria E, Vázquez F, Rubinat E, Granado-Casas M et al.(2017). Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes. Cardiovascular Diabetology vol. 16, (1)

Mishra R, Chesi A, Cousminer DL, Hawa MI, Bradfield JP, Hodge KM, Guy VC, Hakonarson H et al.(2017). Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes. BMC Med vol. 15, (1) 88-88.

Leslie RD, Jerram ST(2017). Stratifying diabetes: Desperately seeking specificity. Diabetes vol. 66, (4) 801-803.

Paul DS, Teschendorff AE, Dang MAN, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S et al.(2016). Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. Nat Commun vol. 7, 13555-13555.

Stunnenberg HG, Abrignani S, Adams D, de Almeida M, Altucci L, Amin V, Amit I, Antonarakis SE et al.(2016). The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell vol. 167, (5) 1145-1149.

Schloot NC, Pham MN, Hawa MI, Pozzilli P, Scherbaum W, Schott M, Kolb H, Hunter S et al.(2016). Inverse relationship between organ-specific autoantibodies and systemic immune mediators in type 1 diabetes and type 2 diabetes: Action LADA 11. Diabetes Care vol. 39, (11) 1932-1939.

Yang Z, Wong A, Kuh D, Paul DS, Rakyan VK, Leslie RD, Zheng SC, Widschwendter M et al.(2016). Correlation of an epigenetic mitotic clock with cancer risk. Genome Biology vol. 17, (1)

Leslie RD, Jerram S(2016). Variation and the spice of life. Am J Clin Nutr vol. 104, (4) 955-956.

Østergaard JA, Laugesen E, Leslie RD(2016). Should There be Concern About Autoimmune Diabetes in Adults? Current Evidence and Controversies. Curr Diab Rep vol. 16, (9) 82-82.

Leslie RD, Palmer J, Schloot NC, Lernmark A(2016). Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia vol. 59, (1) 13-20.

Dang MN, Bradford CM, Pozzilli P, Leslie RD(2016). Methylation analysis in distinct immune cell subsets in type 1 diabetes. Methods in Molecular Biology vol. 1433, 143-151.

Hernandez M, Mollo A, Marsal JR, Esquerda A, Capel I, Puig-Domingo M, Pozzilli P, de Leiva A et al.(2015). Insulin secretion in patients with latent autoimmune diabetes (LADA): Half way between type 1 and type 2 diabetes: Action LADA 9. BMC Endocrine Disorders vol. 15, (1)

Xiang Y, Huang G, Shan Z, Pan L, Luo S, Yang L, Shi L, Li Q et al.(2015). Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5. Acta Diabetologica vol. 52, (6) 1121-1127.

Wang B, Hawa MI, Rijsdijk FV, Fain PR, Paschou SA, Boehm BO, Steck AK, Snieder H et al.(2015). Heritability of thyroid peroxidase autoantibody levels in type 1 diabetes: evidence from discordant twin pairs. Diabetologia vol. 58, (9) 2079-2086.

O'Hare JP, Millar-Jones D, Hanif W, Hicks D, Leslie RD, Bain SC, Barnett AH(2015). The revised NICE draft guideline for type 2 diabetes: Still a long way to go. The Lancet Diabetes and Endocrinology vol. 3, (9) 679-680.

Li X, Liu L, Xiang Y, Huang G, Leslie RD, Zhou Z(2015). Latent autoimmune diabetes in adults with low-titer GAD antibodies: similar disease progression with type 2 diabetes: A Nationwide, multicenter prospective study (LADA China Study 3). Diabetes care 2015;38:16-21. Diabetes Care vol. 38, (3)

Lauria A, Barker A, Schloot N, Hosszufalusi N, Ludvigsson J, Mathieu C, Mauricio D, Nordwall M et al.(2015). BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children. Eur J Endocrinol vol. 172, (2) 107-113.

Migdalis I, Leslie D, Mavrogiannaki A, Papanas N, Valensi P, Vlassara H(2015). Diabetes Mellitus 2014. Int J Endocrinol vol. 2015,

Liu L, Li X, Xiang Y, Huang G, Lin J, Yang L, Zhao Y, Yang Z et al.(2015). Latent autoimmune diabetes in adults with low-titer gad antibodies: Similar disease progression with type 2 diabetes :A nationwide, multicenter prospective study (lada china study 3). Diabetes Care vol. 38, (1) 16-21.

Laugesen E, Østergaard JA, Leslie RDG(2015). Latent autoimmune diabetes of the adult: Current knowledge and uncertainty. Diabetic Medicine vol. 32, (7) 843-852.

O'Hare JP, Hanif W, Millar-Jones D, Bain S, Hicks D, Leslie RD, Barnett AH(2015). NICE guidelines for Type 2 diabetes: Revised but still not fit for purpose. Diabetic Medicine vol. 32, (11) 1398-1403.

Juhl CB, Bradley U, Holst JJ, Leslie RD, Yderstraede KB, Hunter S, Consortium ALADA(2014). Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes: Action LADA 8. DIABETIC MEDICINE vol. 31, (8) 941-945.

Hawa MI, Buchan AP, Ola T, Wun CC, DeMicco DA, Bao W, Betteridge DJ, Durrington PN et al.(2014). LADA and CARDS: a prospective study of clinical outcome in established adult-onset autoimmune diabetes. Diabetes Care vol. 37, (6) 1643-1649.

Zhao Y, Yang L, Xiang Y, Liu L, Huang G, Long Z, Li X, Leslie RD et al.(2014). Dipeptidyl peptidase 4 inhibitor sitagliptin maintains β-cell function in patients with recent-onset latent autoimmune diabetes in adults: one year prospective study. J Clin Endocrinol Metab vol. 99, (5) E876-E880.

Barker A, Lauria A, Schloot N, Hosszufalusi N, Ludvigsson J, Mathieu C, Mauricio D, Nordwall M et al.(2014). Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study. Diabetes Obes Metab vol. 16, (3) 262-267.

Hayes DF, Markus HS, Leslie RD, Topol EJ(2014). Personalized medicine: risk prediction, targeted therapies and mobile health technology. BMC MEDICINE vol. 12, Article ARTN 37,

Hawa MI, Kolb H, Schloot N, Beyan H, Paschou SA, Buzzetti R, Mauricio D, De Leiva A et al.(2014). Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7 (Diabetes Care (2013) 36, (908-913)). Diabetes Care vol. 37, (5)

Leslie RDG, Bradford C(2014). Autoimmune diabetes: Caught in a NET. Diabetes vol. 63, (12) 4018-4020.

Migdalis I, Leslie D, Papanas N, Valensi P, Vlassara H(2014). Diabetes mellitus. Int J Endocrinol vol. 2014,

Bradford CM, Hawa M, Sumaria N, Dang MN, Beyan H, Davies G, Jensen H, Tsang V et al. (2013). Understanding auto-antigen expression and regulation in human medullary thymic epithelial cells (mTECs). IMMUNOLOGY. vol. 140, 187-187.

Hitman GA, Leslie RD, Holt RIG(2013). GLP-1-based diabetes therapies; trial by media. Diabetic Medicine vol. 30, (10) 1147-1147.

Paschou SA, Leslie RD(2013). Personalizing guidelines for diabetes management: twilight or dawn of the expert?. BMC Med vol. 11,

Xiang Y, Zhou Z, Deng C, Leslie RD(2013). Latent autoimmune diabetes in adults in Asians: Similarities and differences between East and West. Journal of Diabetes vol. 5, (2) 118-126.

Gemma C, Ramagopalan SV, Down TA, Beyan H, Hawa MI, Holland ML, Hurd PJ, Giovannoni G et al.(2013). Inactive or moderately active human promoters are enriched for inter-individual epialleles. Genome Biol vol. 14, (5)

Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics : official journal of the DNA Methylation Society vol. 8, (4) 445-454.

Lowe R, Gemma C, Beyan H, Hawa MI, Bazeos A, Leslie RD, Montpetit A, Rakyan VK et al.(2013). Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics vol. 8, (4) 445-454.

Chiu SWY, Leslie RDG, Beyan H(2013). Non-genetic factors in the pathogenesis of type 1 diabetes. Diabetes and Viruses, vol. 9781461440512,

Leslie RDG, Ho-Le L, Beyan H(2013). Viruses and autoimmune diabetes: A history. Diabetes and Viruses, vol. 9781461440512,

Zhou Z, Xiang Y, Ji L, Jia W, Ning G, Huang G, Yang L, Lin J et al.(2013). Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China Study): A nationwide, multicenter, clinic-based cross-sectional study. Diabetes vol. 62, (2) 543-550.

Merger SR, Leslie RD, Boehm BO(2013). The broad clinical phenotype of Type 1 diabetes at presentation. Diabetic Medicine vol. 30, (2) 170-178.

Leslie RDG(2013). Type 1 diabetes reviews series. Diabetic Medicine vol. 30, (2)

Beyan H, Down TA, Ramagopalan SV, Uvebrant K, Nilsson A, Holland ML, Gemma C, Giovannoni G et al.(2012). Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans. Genome Res vol. 22, (11) 2138-2145.

Beyan H, Wen L, Leslie RD(2012). Guts, germs, and meals: the origin of type 1 diabetes. Curr Diab Rep vol. 12, (5) 456-462.

Rajendram R, Fraser-Bell S, Kaines A, Michaelides M, Hamilton RD, Esposti SD, Peto T, Egan C et al.(2012). A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3. Arch Ophthalmol vol. 130, (8) 972-979.

Strom A, Menart B, Simon MC, Pham MN, Kolb H, Roden M, Pozzilli P, Leslie RDG et al.(2012). Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6. Cytokine vol. 58, (2) 148-151.

Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M et al.(2012). Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes vol. 61, (5) 1192-1198.

Pham MN, Hawa MI, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum WA, Seissler J et al.(2012). Increased serum concentrations of adhesion molecules but not of chemokines in patients with Type2 diabetes compared with patients with Type1 diabetes and latent autoimmune diabetes in adult age: Action LADA5. Diabetic Medicine vol. 29, (4) 470-478.

Leslie RD, Ludvigsson J(2012). The viral aetiology of diabetes: A tribute to Keith Taylor (1929-2012). Diabetic Medicine vol. 29, (4)

Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B et al.(2012). BLUEPRINT to decode the epigenetic signature written in blood. NATURE BIOTECHNOLOGY vol. 30, (3) 224-226.

Bizzarri C, Pinto RM, Pitocco D, Astorri E, Cappa M, Hawa M, Giannone G, Palermo A et al.(2012). Diabetes-related autoantibodies in children with acute lymphoblastic leukemia. Diabetes Care vol. 35, (3)

Ludvigsson J, Krisky D, Casas R, Battelino T, Castaño L, Greening J, Kordonouri O, Otonkoski T et al.(2012). GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. New England Journal of Medicine vol. 366, (5) 433-442.

Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum WA et al.(2012). Erratum: Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4 (Diabetologia DOI: 10.1007/s00125-011-2088-6). Diabetologia vol. 55, (2)

Hawa MI, Kolb H, Schloot N, Beyan H, Paschou SA, Buzzetti R, Mauricio D, De Leiva A et al.(2012). Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes Care

Leslie RD, Lansang MC, Coppack S(2012). Diabetes: Clinician's desk reference.

Leslie RD, Beyan H(2011). Metabolomics makes a mark: early changes associated with autoimmune diabetes. Diabetes vol. 60, (11) 2688-2690.

Hadavi S, Noyce AJ, Leslie RD, Giovannoni G(2011). Stiff person syndrome. Pract Neurol vol. 11, (5) 272-282.

Leslie RD(2011). Towards secondary prevention of Type 1 diabetes. DIABETIC MED vol. 28, (10) 1140-1140.

Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al.(2011). Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet vol. 7, (9)

Leslie D (2011). Type 1 Diabetes-Not All in the Genes. JOURNAL OF MEDICAL VIROLOGY. vol. 83, 1670-1670.

Xiang Y, Zhou P, Li X, Huang G, Liu Z, Xu A, Leslie RD, Zhou Z(2011). Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China. Diabetes Care vol. 34, (7) 1639-1641.

Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum W et al.(2011). Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4. Diabetologia vol. 54, (7) 1630-1638.

Beyan H, Rakyan VK, Down TA, Hawa MI, Maslau S, Wallace C, Aden D, Mein CA et al. (2010). Identification of type 1 diabetes-associated methylation variable positions that precede disease diagnosis. DIABETOLOGIA. vol. 53, S145-S146.

Beyan H, Drexhage RC, van der Heul Nieuwenhuijsen L, de Wit H, Padmos RC, Schloot NC, Drexhage HA, Leslie RD(2010). Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins. Diabetes vol. 59, (7) 1751-1755.

Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, Boos CJ, Xing W et al.(2010). A Prospective Randomized Trial of Intravitreal Bevacizumab or Laser Therapy in the Management of Diabetic Macular Edema (BOLT Study) 12-Month Data: Report 2. OPHTHALMOLOGY vol. 117, (6) 1078-U76.

Beyan H, Rakyan VK, Down TA, Maslau S, Hawa MI, Boehm BO, Beck S, Leslie RD (2010). Whole-Genome Identification and Functional Analysis of Type 1 Diabetes-Associated Epigenetic Variation. DIABETES. vol. 59, A56-A56.

Pozzilli P, Leslie RD, Chan J, De Fronzo R, Monnier L, Raz I, Del Prato S(2010). The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach. Diabetes Metab Res Rev vol. 26, (4) 239-244.

Rakyan VK, Down TA, Maslau S, Andrew T, Yang T-P, Beyan H, Whittaker P, McCann OT et al.(2010). Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res vol. 20, (4) 434-439.

Leslie RD(2010). Predicting adult-onset autoimmune diabetes: clarity from complexity. Diabetes vol. 59, (2) 330-331.

Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Alexander Fleming G, Pozzilli P et al.(2009). Challenges in developing endpoints for type 1 diabetes intervention studies. Diabetes/Metabolism Research and Reviews vol. 25, (8) 694-704.

Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Snieder H, Boehm BO et al. (2009). Common and unique environmental events associated with innate and adaptive immunity in type 1 diabetes. DIABETOLOGIA. vol. 52, S197-S198.

Leslie RDG, Cohen RM(2009). Biologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications. J Diabetes Sci Technol vol. 3, (4) 635-643.

Leslie RD, Hawa MI, Schloot N, Sarti C, Williams R, Buzzetti R, Alemanno I, Kolb H et al. (2009). Frequency and Phenotypic Characteristics of Autoimmune Diabetes in Adult European Patients with Diabetes. DIABETES. vol. 58, A258-A258.

Pozzilli P, Leslie RD(2009). New prospects for immunotherapy at diagnosis of type 1 diabetes. DIABETES-METAB RES vol. 25, (4) 299-301.

Beyan H, Buckley LR, Bustin SA, Yousaf N, Pozzilli P, Leslie RD(2009). Altered monocyte cyclo-oxygenase response in non-obese diabetic mice. Clin Exp Immunol vol. 155, (2) 304-310.

Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJT, de Ridder D, Aanstoot HJ, Lam-Tse WK et al.(2009). LADA Consortium: Distinct monocyte gene-expression profiles in autoimmune diabetes. (vol 57, pg 2768, 2008). DIABETES vol. 58, (1) 296-296.

Hawa MI, Thivolet C, Mauricio D, Alemanno I, Cipponeri E, Collier D, Hunter S, Buzzetti R et al.(2009). Metabolic Syndrome and Autoimmune Diabetes: Action LADA 3. DIABETES CARE vol. 32, (1) 160-164.

Allen JS, Pang K, Skowera A, Ellis R, Rackham C, Lozanoska-Ochser B, Tree T, Leslie RDG et al.(2009). Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture. DIABETES vol. 58, (1) 138-145.

Leslie RDG, Kilpatrick ES(2009). Translating the A1C assay into estimated average glucose values: response to Nathan et al. Diabetes Care vol. 32, (1)

Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RDG, Peakman M, Tree TIM(2008). Increased resistance to CD4(+)CD25(hi) regulatory T cell-mediated suppression in patients with type 1 diabetes. CLIN EXP IMMUNOL vol. 154, (3) 353-359.

Leslie RDG, Kolb H, Schloot NC, Buzzetti R, Mauricio D, De Leiva A, Yderstraede K, Sarti C et al.(2008). Diabetes classification: grey zones, sound and smoke: Action LADA 1. DIABETES-METAB RES vol. 24, (7) 511-519.

Padmos RC, Schloot NC, Beyan H, Ruwhof C, Staal FJT, de Ridder D, Aanstoot H-J, Lam-Tse WK et al.(2008). Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes vol. 57, (10) 2768-2773.

Brophy S, Yderstraede K, Mauricio D, Hunter S, Hawa M, Pozzilli P, Schernthaner G, Schloot N et al.(2008). on behalf of the Action LADA Group: Time to insulin initiation cannot be used in defining latent autoimmune diabetes in adults. (vol 31, pg 439, 2008). DIABETES CARE vol. 31, (10) 2077-2077.

Leslie RDG, Beyan H, Drexhage HA, De Witt HJ(2008). Abnormal monocyte-related signatures in type 1 diabetes; a study of identical twins. DIABETOLOGIA vol. 51, S119-S119.

Schloot NC, Hawa MI, Scherbaum WA, Pozzilli P, Leslie R, Seissler J, Action LADA Consortium(2008). Organ specific autoantibodies in patients with type 1 diabetes, LADA and type 2 diabetes. DIABETOLOGIA vol. 51, S235-S235.

Beyan H, Von Hofe E, Leslie RD(2008). Study of T cell response to li-key/MHC class II epitope hybrides in human type 1 diabetes. DIABETOLOGIA vol. 51, S232-S232.

Hitman GA, Hawa MI, Leslie RDG, Ola T, Wun CC, DeMicco D, Betteridge DJ, Durrington PN et al.(2008). The clinical implications of GAD antibody positivity in older patients with established non-insulin requiring diabetes. DIABETOLOGIA vol. 51, S230-S231.

Hawa MI, Cipponeri E, Collier D, Loh Y, Pozzilli P, Brophy S, Hunter S, Thivolet C et al.(2008). The prevalence of metabolic syndrome is much less in LADA and type 1 diabetes than type 2 diabetes: ACTION LADA 3. DIABETOLOGIA vol. 51, S155-S155.

Beyan H, De Witt HJ, Drexhage HA, Leslie RD (2008). Abnormal monocyte-related signatures in type 1 diabetes: A study of identical twins. DIABETES. vol. 57, A89-A90.

Beyan H, Von Hofe E, Leslie RD (2008). Study of T cell response to Ii-Key/MHC class II epitope hybrides in human type 1 diabetes. DIABETES. vol. 57, A18-A18.

Brophy S, Yderstrede K, Mauricio D, Hunter S, Hawa M, Pozzilli P, Schernthaner G, Schoot N et al.(2008). Time to insulin initiation cannot be used in defining latent autoimmune diabetes in adults. DIABETES CARE vol. 31, (3) 439-441.

Mohsin F, Hitman G, Leslie R, Hawa M, Biswas K, Zabeen B, Nahar N, Azad K(2008). Clinical Profile and Autoantibody Status in Younger Onset Diabetes in Bangladesh. HORM RES vol. 70, 14-14.

Bevan H, De Witt HJ, Leslie RDG, Drexhage HA(2007). Abnormal monocyte-related signatures in type 1 diabetes; A study of identical twins. ACTA DIABETOL vol. 44, S4-S4.

Padmos RC, Schloot NC, Beyan H, Leslie RD, Drexhage HA, Act LADA Consortium(2007). Adult onset type 1 diabetes and LADA are discriminated from juvenile onset type 1 diabetes by a characteristic pro-inflammatory gene-expression signature in monocytes. ACTA DIABETOL vol. 44, S37-S38.

Beyan H, De Witt HJ, Leslie RDG, Dreyhage HA (2007). Abnormal monocyte-related biomarkers in type 1 diabetes; a study of identical twins. DIABETOLOGIA. vol. 50, S191-S191.

Zhou Z, Xiang Y, Yang L, Huang G, Yan X, Peng H, Liu Z, Hagopian W et al. (2007). LADA China Study 1: prevalence of latent autoimmune diabetes in adults among Chinese newly diagnosed type 2 diabetics. DIABETOLOGIA. vol. 50, S132-S132.

Xiang Y, Lin Y, Huang G, Yan X, Peng H, Liu Z, Hagopain W, Leslie RDG et al. (2007). Prevalence of metabolic syndrome in latent autoimmune diabetes in adults (LADA): data from a multicenter investigation (LADA China). DIABETOLOGIA. vol. 50, S131-S132.

Zhou ZG, Yang L, Xiang YF, Huang G, Yan X, Peng H, Liu ZQ, Hagopian W et al. (2007). LADA China study 1: Prevalence of latent autoimmune diabetes in adults (LADA) in China. DIABETES. vol. 56, A275-A275.

Beyan H, Humphreys RE, Von Hofe E, Leslie RD (2007). Study of T cell response to Ii-Key/MHC class Ii epitope hybrid peptides in human type 1 diabetes. DIABETES. vol. 56, A96-A96.

Cohen RM, Snieder H, Lindsell CJ, Beyan H, Hawa MI, Blinko S, Edwards R, Leslie RDG(2007). Evidence for independent heritability of the glycation gap (Glycosylation Gap) fraction of HbA<inf>1c</inf> in nondiabetic twins: Response to Nuttall [5]. Diabetes Care vol. 30, (4)

Beyan H, Goodier MR, Nawroly NS, Hawa MI, Bustin SA, Ogunkolade WB, Londei M, Yousaf N et al.(2007). Altered monocyte cyclooxygenase response to lipopolysaccharlde in type 1 diabetes.(vol 55, pg 3439, 2006). DIABETES vol. 56, (2) 549-549.

Beyan H, Goodier MR, Nawroly NS, Hawa MI, Bustin SA, Ogunkolade WB, Londei M, Yousaf N et al.(2007). Erratum: Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes (Diabetes (2006) 55 (3439-3445)). Diabetes vol. 56, (2)

Beyan H, Goodier MR, Nawroly NS, Hawa MI, Bustin SA, Ogunkolade WB, Londei M, Yousaf N et al.(2006). Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes. Diabetes vol. 55, (12) 3439-3445.

Teng J, Leslie RDG(2006). Type 1 diabetes and latent autoimmune diabetes in adults. Zhong Nan Da Xue Xue Bao Yi Xue Ban vol. 31, (6) 809-813.

Beyan H, Ola T, David R, Leslie G (2006). Progression of autoimmune diabetes: slowly progressive insulin-dependent diabetes mellitus or latent autoimmune diabetes of adult. Ann N Y Acad Sci. vol. 1079, 81-89.

Hawa MI, Ola TO, Gigante A, Teng J, Leslie RDG, Action LADA consortium (2006). Action LADA, a multinational European project in latent autoimmune diabetes in adults (LADA). DIABETOLOGIA. vol. 49, 182-182.

Hassan Z, Hawa MI, Faruque MO, Biswas KB, Azad K, Khan AKA, Ali L, Leslie RDG et al. (2006). INSVNTR polymorphism in young onset diabetes subjects of Bangladesh. DIABETOLOGIA. vol. 49, 178-178.

Goodier MR, Nawroly N, Beyan H, Hawa M, Leslie RDG, Londei M(2006). Identical twins discordant for type 1 diabetes show a different pattern of in vitro CD56+ cell activation. Diabetes Metab Res Rev vol. 22, (5) 367-375.

Alper CA, Husain Z, Larsen CE, Dubey DP, Stein R, Day C, Baker A, Beyan H et al.(2006). Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes. J Autoimmun vol. 27, (2) 89-95.

Cohen RM, Snieder H, Lindsell CJ, Beyan H, Hawa MI, Blinko S, Edwards R, Spector TD et al. (2006). Evidence for independent heritability of the glycation gap, (glycosylation gap) fraction of HbA(1c) in nondiabetic twins. DIABETES CARE. vol. 29, 1739-1743.

Beyan H, Rakyana V, Hawa MI, Browne P, Beck S, Leslie DRD (2006). Epigenetic methylation of type 1 diabetes susceptibility genes. DIABETES. vol. 55, A545-A545.

Pozzilli P, Astorri E, Bizzari C, Cappa M, De Rossi G, Leslie RDG, Hawa M, Spoletini ML et al. (2006). GAD, IA2 and insulin autoantibodies in children diagnosed with acute lymphoblastic leukaemia: Relevance for type 1 diabetes. DIABETES. vol. 55, A412-A412.

Leslie RDG, Williams R, Pozzilli P(2006). Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: One end of the rainbow. J CLIN ENDOCR METAB vol. 91, (5) 1654-1659.

Ola TO, Gigante A, Leslie RDG(2006). Latent autoimmune diabetes of adults (LADA). NUTR METAB CARDIOVAS vol. 16, (3) 163-167.

Hawa MI, Picardi A, Costanza F, D'Avola D, Beretta Anguissola G, Guglielmi C, Mottini G, Fezeu L et al.(2006). Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon. Clin Immunol vol. 118, (2-3) 229-232.

Agardh C-D, Cilio CM, Lethagen A, Lynch K, Leslie RDG, Palmér M, Harris RA, Robertson JA et al.(2005). Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications vol. 19, (4) 238-246.

Hawa MI, Bonfanti R, Valeri C, Delli Castelli M, Beyan H, Leslie RDG(2005). No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins. Diabetes Care vol. 28, (6) 1415-1418.

Schmidt KD, Valeri C, Leslie RDG(2005). Autoantibodies in Type 1 diabetes. Clin Chim Acta vol. 354, (1-2) 35-40.

Cohen RM, Snieder H, Lindsell C, Beyan H, Hawa M, Blinko S, Edwards R, Leslie RDG (2005). Heritability of HbA1c (A1c) resides partly in the glycosylation gap. DIABETES. vol. 54, A99-A100.

Redondo MJ, Hawa M, Bugawan TL, Babu S, Yu LP, Fernando M, Beyan H, Yan F et al. (2005). Polymorphisms in the vitamin D receptor, alone and in combination with HLA DQ, improve prediction of T1DM in monozygotic twins of patients. DIABETES. vol. 54, A274-A274.

Valiante S, Barchetta I, Calabria M, Leomanni C, Manfrini S, Hawa M, Leslie D, Pozzilli P et al. (2005). Prevalence of GAD antibodies in diabetic patients with or without the metabolic syndrome. DIABETES. vol. 54, A310-A310.

Hassan Z, Hawa MI, Faruque MO, Ali L, Azad K, Leslie RDG, Khan AKA, Hitman GA (2005). Prevalence of type 1 diabetes in a Bangladeshi population based on the presence of GAD and IA2 antibody. DIABETOLOGIA. vol. 48, A55-A55.

Beyan H, Humphreys RE, Leslie RDG (2005). Study of T cell response to Ii-Key/MHC class II epitope hybrid peptides in human type I diabetes. DIABETOLOGIA. vol. 48, A99-A99.

Leslie RDG, Delli Castelli M(2004). Age-dependent influences on the origins of autoimmune diabetes: evidence and implications. Diabetes vol. 53, (12) 3033-3040.

Valeri C, Pozzilli P, Leslie D(2004). Glucose control in diabetes. Diabetes Metab Res Rev vol. 20 Suppl 2, S1-S8.

Hawa MI, Valorani MG, Buckley LR, Beales PE, Afeltra A, Cacciapaglia F, Leslie RD, Pozzilli P(2004). Lack of effect of vitamin D administration during pregnancy and early life on diabetes incidence in the non-obese diabetic mouse. Horm Metab Res vol. 36, (9) 620-624.

Leslie RDG(2004). Preventing type 1 diabetes mellitus: hype and hope. Clin Med (Lond) vol. 4, (5) 442-446.

(2004). 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia vol. 47, (Suppl 1) A1-A464.

Beyan H, Valorani GM, Imdiab G, Pozzilli P, Leslie RDG (2004). Abnormalities in plasma 1,25-dihydroxyvitamin D3, and cellular 1-alpha hydroxylase and Cyclooxygenase-2 mRNA levels in recent-onset type 1 diabetes. DIABETOLOGIA. vol. 47, A188-A188.

Ola TO, Hawa MI, Beck-Nielsen H, Buzzetti R, Scherbaum W, Kolb H, Tuomilehto J, Thivolet C et al. (2004). Action LADA a multinational European project in latent autoimmune diabetes in adults. DIABETOLOGIA. vol. 47, A113-A113.

Hawa MI, Valeri C, Castelli MD, Bonfante R, Beyan H, Leslie RDG (2004). Responses to intravenous glucose non-diabetic twins and healthy controls: a prospective follow-up study. DIABETOLOGIA. vol. 47, A173-A173.

Beyan H, Buckley LR, Bustin S, Londei M, Leslie RDG (2004). Altered isoform switch in monocyte Cox-1 and Cox-2 response to lipopolysaccharide in type 1 diabetes. DIABETES. vol. 53, A27-A27.

Agardh CD, Cilio CM, Lethagen A, Lynch K, Leslie RDG, Palmer M, Harris RA, Robertson J et al. (2004). Clinical evidence for safety, efficacy, and immunomodulation by a novel therapeutic intended for treatment of autoimmune diabetes. DIABETES. vol. 53, A63-A63.

Beyan H, Valorani MG, Valente L, Pozzilli P, Leslie RDG (2004). Plasma 1,25-dihydroxyvitamin D3,one-alpha hydroxylase and vitamin D receptor mRNA in patients with recent-onset type I diabetes. DIABETES. vol. 53, A296-A296.

Hawa M, Beyan H, Leslie RDG(2004). Principles of autoantibodies as disease-specific markers. Autoimmunity vol. 37, (4) 253-256.

Pozzilli P, Leslie D(2003). Endocrinology and Art. Louise ou la Servante Bretonne. J Endocrinol Invest vol. 26, (10)

Leslie RDG, Beyan H, Sawtell P, Boehm BO, Spector TD, Snieder H(2003). Level of an advanced glycated end product is genetically determined: a study of normal twins. Diabetes vol. 52, (9) 2441-2444.

Beyan H, Goodier MR, Nawroly NS, Hawa MI, Buckley LR, Bustin S, Yousaf N, Londei M et al. (2003). Altered isoform switch in monocyte COX-1 and COX-2 response to lipopolysaccaride in Type 1 diabetes. DIABETOLOGIA. vol. 46, A10-A10.

Buckley LR, Hawa MI, Beyan H, Valorani MG, Pozzilli P, Leslie RDG (2003). Altered monocyte cyclooygenase expression in non-obese diabetic mice. DIABETOLOGIA. vol. 46, A180-A180.

Delli Castelli M, Leslie RDG(2003). Diabetic retinopathy: medical management and assessment. Hosp Med vol. 64, (7) 400-403.

Beyan H, Buckley LR, Yousaf N, Londei M, Leslie RDG(2003). A role for innate immunity in type 1 diabetes?. Diabetes Metab Res Rev vol. 19, (2) 89-100.

Lohmann T, Londei M, Hawa M, Leslie RDG (2003). Humoral and cellular autoimmune responses in stiff person syndrome. MYASTHENIA GRAVIS AND RELATED DISORDERS. Editors: Agius, MA, Richman, DP, Fairclough, RH, Maselli, RA et al., vol. 998, 215-222.

Hawa MI, Pilcher CC, Elliot RB, Leslie RDG (2002). Antibody isotype maturation and restriction occurs early in Type 1 diabetes. DIABETOLOGIA. vol. 45, A157-A157.

Buckley LR, Hawa MI, Beyan H, Pozzilli P, Leslie RDG (2002). Role of monocyte cyclooxygenase-2 in Non-Obese Diabetic mice. DIABETOLOGIA. vol. 45, A116-A116.

Hawa MI, Leslie RDG(2002). GAD antigen and its significance in type I diabetes. J Endocrinol Invest vol. 25, (7)

Bartsocas CS, Leslie RDG(2002). Genetics of diabetes mellitus. Am J Med Genet vol. 115, (1) 1-3.

Hawa MI, Beyan H, Buckley LR, Leslie RDG(2002). Impact of genetic and non-genetic factors in type 1 diabetes. Am J Med Genet vol. 115, (1) 8-17.

Leslie RDG, Pozzilli P (2002). An introduction to new advances in diabetes. DIABETES-METABOLISM RESEARCH AND REVIEWS. vol. 18, S1-S6.

Snieder H, Sawtell PA, Ross L, Walker J, Spector TD, Leslie RD(2001). HbA(1c) levels are genetically determined even in type 1 diabetes: evidence from healthy and diabetic twins. Diabetes vol. 50, (12) 2858-2863.

Leslie D, Lipsky P, Notkins AL(2001). Autoantibodies as predictors of disease. J Clin Invest vol. 108, (10) 1417-1422.

Hawa MI, Leslie RD(2001). Early induction of type 1 diabetes. Clin Exp Immunol vol. 126, (2) 181-183.

Beyan H, Goodier R, Sirwan-Muhamad N, Hawa MI, Buckley L, Sawtell P, Bustin S, Yousaf N et al.(2001). Cyclo-oxygenase expression in identical twins discordant for type 1 diabetes. DIABETOLOGIA vol. 44, A99-A99.

Buckley LR, Beales PE, Hawa MI, Beyan H, Rosignoli G, Yousaf N, Leslie RDG(2001). Increased monocyte cycloxygenase-2 expression in female non obese diabetic mice. DIABETOLOGIA vol. 44, A99-A99.

Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, Leslie RDG(2001). Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States (vol 44, pg 354, 2001). DIABETOLOGIA vol. 44, (7) 927-927.

Leslie RDG, Beyan H, Goodier M, Sirwan-Muhammad N, Buckley LR, Hawa MI, Sawtell PA, Bustin S et al.(2001). Increased cyclo-oxygenase-2 (COX-2) expression in type 1 diabetes: A study of identical twins discordant for diabetes. DIABETES vol. 50, A198-A198.

Metcalfe KA, Hitman GA, Rowe RE, Hawa M, Huang XJ, Stewart T, Leslie RDG(2001). Concordance for type 1 diabetes in identical twins is affected by insulin genotype. DIABETES CARE vol. 24, (5) 838-842.

Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, Leslie RD(2001). Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia vol. 44, (3) 354-362.

Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, Leslie RDG(2001). Erratum: Heterogeneity of Type I diabetes: Analysis of monozygotic twins in Great Britain and the United States (Diabetologia (2001) 44 (345-362)). Diabetologia vol. 44, (7)

Leslie RD(2000). Report on "the 25th anniversary of the discovery of islet cell antibodies". Diabetologia vol. 43, (8) 27-29.

Lo SSS, Medici F, Rowe R, Hawa M, St. John Sutton M, Leslie RDG(2000). Effects of acute hyperglycaemia on cardiac function: An echocardiographic study of monozygotic twins. International Journal of Cardiology vol. 74, (2-3) 139-144.

Salvetti M, Ristori G, Bomprezzi R, Pozzilli P, Leslie RDG(2000). Twins: Mirrors of the immune system. Immunology Today vol. 21, (7) 342-347.

Schulz RM, Hawa M, Leslie RDG, Sinigaglia F, Passini N, Rogge L, Picard JK, Londei M(2000). Proliferative responses to selected peptides of IA-2 in identical twins discordant for Type 1 diabetes. Diabetes/Metabolism Research and Reviews vol. 16, (3) 150-156.

Hawa MI, Fava D, Medici F, Deng YJ, Notkins AL, De Mattia G, Leslie RDG(2000). Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: Isotype restriction and polyclonality. Diabetes Care vol. 23, (2) 228-233.

Lohmann T, Hawa M, Leslie RDG, Lane R, Picard J, Londei M(2000). Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus. Lancet vol. 356, (9223) 31-35.

O'Byrne S, Forte P, Roberts LJ, Morrow JD, Johnston A, Änggård E, Leslie RDG, Benjamin N(2000). Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion. Diabetes vol. 49, (5) 857-862.

Kallmann BA, Lampeter EF, Hanifi-Moghaddam P, Hawa M, Leslie RDG, Kolb H(1999). Cytokine secretion patterns in twins discordant for Type I diabetes. Diabetologia vol. 42, (9) 1080-1085.

Medici F, Hawa MI, Giorgini A, Panelo A, Solfelix CM, Leslie RDG, Pozzilli P(1999). Antibodies to GAD65 and a tyrosine phosphatase-like molecule IA-2ic in Filipino type I diabetic patients. Diabetes Care vol. 22, (9) 1458-1461.

Medici F, Hawa M, Ianari A, Pyke DA, Leslie RDG(1999). Concordance rate for type II diabetes mellitus in monozygotic twins: Actuarial analysis. Diabetologia vol. 42, (2) 146-150.

Leslie RDG, Atkinson MA, Notkins AL(1999). Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes. Diabetologia vol. 42, (1) 3-14.

Pozzilli P, Leslie RDG(1999). Aspirin and diabetes. Practical Diabetes International vol. 16, (8) 259-261.

Pozzilli P, Leslie RDG(1999). Glycaemic outcome in patients with type 2 diabetes referred to a hospital clinic because of poor control. Practical Diabetes International vol. 16, (8) 247-249.

Leslie RDG(1999). United Kingdom Prospective Diabetes Study (UKPDS): What now or so what?. Diabetes/Metabolism Research and Reviews vol. 15, (1) 65-71.

Fava D, Gardner S, Pyke D, Leslie RDG(1998). Evidence that the age at diagnosis of IDDM is genetically determined. Diabetes Care vol. 21, (6) 925-929.

Notkins AL, Lan MS, Leslie RDG(1998). IA-2 and IA-2β: The immune response in IDDM. Diabetes/Metabolism Reviews vol. 14, (1) 85-93.

Boyton RJ, Lohmann T, Londei M, Kalbacher H, Halder T, Frater AJ, Douek DC, Leslie RDG et al.(1998). Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: Analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. International Immunology vol. 10, (12) 1765-1776.

Pozzilli P, Visalli N, Buzzetti R, Cavallo MG, Marietti G, Hawa M, Leslie RDG(1998). Metabolic and immune parameters at clinical onset of insulin-dependent diabetes: A population-based study. Metabolism: Clinical and Experimental vol. 47, (10) 1205-1210.

Leslie RDG, Pyke DA(1997). Insulin dependent diabetes is probably due to environmental effect during childhood [7]. British Medical Journal vol. 315, (7114)

Leslie RDG, Taylor R, Pozzilli P(1997). The role of insulin resistance in the natural history of Type 1 diabetes. Diabetic Medicine vol. 14, (4) 327-331.

Pozzilli P, Leslie RDG(1997). Hyperexpression of GAD in the islets may be relevant but is it sufficient to induce antoimmune insulitis 3. Diabetologia vol. 40, (3) 357-361.

Fava D, Hawa M, Rowe R, Pyke DA, Leslie RDG(1997). Clinical hypoglycemia before diabetes is rare. Diabetes Care vol. 20, (4) 678-679.

Dubrey SW, Beetham R, Miles J, Noble MIM, Rowe R, Leslie RDG(1997). Increased urinary albumin and retinol-binding protein in type I diabetes: A study of identical twins. Diabetes Care vol. 20, (1) 84-89.

Hawa M, Rowe R, Lan MS, Notkins AL, Pozzilli P, Christie MR, Leslie RDG(1997). Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes vol. 46, (8) 1270-1275.

Leslie RDG(1996). Intervention in patients with Type I diabetes masquerading as Type II diabetes. Diabetes, Nutrition and Metabolism - Clinical and Experimental vol. 9, (6) 319-324.

Hussain MJ, Peakman M, Gallati H, Lo SSS, Hawa M, Viberti GC, Watkins PJ, Leslie RDG et al.(1996). Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia vol. 39, (1) 60-69.

Leslie RDG, Pyke DA(1996). Concordance between twins for β-cell autoimmunity. Diabetes vol. 45, (9)

Hardman TC, Dubrey SW, Leslie RDG, Lant AF(1996). Erythrocyte sodium-lithium countertransport activity in non-nephropathic diabetic twins. Diabetes Care vol. 19, (1) 32-38.

Pozzilli P, Lunadei M, Frati L, Leslie RDG, Farthing M(1996). From Erasmus to Socrates: Should mobility move from students to teachers? [13]. Lancet vol. 347, (9017)

Hardman TC, Dubrey SW, Leslie RDG, Lant AF(1996). Kinetic behavior of the erythrocyte sodium-lithium countertransporter in nonnephropathic diabetic twins. Metabolism: Clinical and Experimental vol. 45, (10) 1203-1207.

Peakman M, Leslie RDG, Alviggi L, Hawa M, Vergani D(1996). Persistent activation of CD8⁺ T-cells characterizes prediabetic twins. Diabetes Care vol. 19, (11) 1177-1184.

Lohmann T, Leslie RDG, Londei M (1996). T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. Journal of Autoimmunity. vol. 9, 385-389.

Lo SSS, Leslie RDG, Sutton MSJ(1995). Effects of type 1 diabetes mellitus on cardiac function: A study of monozygotic twins. Heart vol. 73, (5) 450-455.

Pozzilli P, Buzzetti R, Giovannini C, Gragnoli C, Leslie RDG(1995). New and old trends for treating organ-specific autoimmune endocrinopathies. Journal of Endocrinology vol. 145, (2) 195-199.

Rowe RE, Leslie RDG(1995). Twin studies in insulin dependent diabetes and other autoimmune diseases. Diabetes/Metabolism Reviews vol. 11, (2) 121-135.

Orrell RW, Lane RJ, Maitland J, Leslie RD(1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus. Lancet vol. 344, (8917)

Lohmann T, Londei M, Leslie RDG, Hawa M, Geysen M, Rodda S(1994). Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. The Lancet vol. 343, (8913) 1607-1608.

Tun RYM, Peakman M, Alviggi L, Hussain MJ, lo SSS, Shattock M, Pyke DA, Bottazzo GF et al.(1994). Importance of persistent cellular and humoral immune changes before diabetes develops: Prospective study of identical twins. BMJ vol. 308, (6936)

Tun RYM, Smith MD, Lo SSS, Rook GAW, Lydyard P, Leslie RDG(1994). Antibodies to Heat Shock Protein 65 kD in Type 1 Diabetes Mellitus. Diabetic Medicine vol. 11, (1) 66-70.

Smerdon RA, Peakman M, Hussain MJ, Wong FS, Watkins PJ, Leslie RDG, Vergani D(1994). CD5⁺ B-cells at the onset of type I diabetes and in the prediabetic period. Diabetes Care vol. 17, (7) 657-664.

Leslie RDG, Elliott RB(1994). Early environmental events as a cause of IDDM: Evidence and implications. Diabetes vol. 43, (7) 843-850.

Dubrey S, Akhras F, Song GJ, Hardman T, Travill C, Hynd J, Noble MIM, Lo SSS et al.(1994). Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type 1 (insulin dependent) diabetes. British Heart Journal vol. 71, (4) 341-348.

Peakman M, Alviggi L, Hussain MJ, Lo SSS, Hawa M, Leslie RDG, Vergani D(1994). Increased expression of T-cell markers of immunological memory associated with protection from type I diabetes: A study of identical twins. Diabetes vol. 43, (5) 712-717.

Pozzilli P, Leslie RDG(1994). Infections and Diabetes: Mechanisms and Prospects for Prevention. Diabetic Medicine vol. 11, (10) 935-941.

Fava D, Leslie RDG, Pozzilli P(1994). Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care vol. 17, (12) 1488-1490.

Dubrey SW, Reaveley DR, Seed M, Lane DA, Ireland H, O'Donnell M, O'Connor B, Noble MI et al.(1994). Risk factors for cardiovascular disease in IDDM: A study of identical twins. Diabetes vol. 43, (6) 831-835.

Leslie RDG, Hawa M (1994). Twin studies in auto-immune disease. Acta Geneticae Medicae et Gemellologiae. vol. 43, 71-81.

Leslie RD, Pozzilli P(1994). Type I diabetes masquerading as type II diabetes. Possible implications for prevention and treatment. Diabetes care vol. 17, (10) 1214-1219.

Lo SSS, John Sutton MS, Leslie RDG(1993). Information on type 1 diabetes mellitus and QT interval from identical twins. The American Journal of Cardiology vol. 72, (3) 305-309.

Leslie RDG, Pyke DA, Braun MM, Caporaso N, Duffy DL, Macdonald AM(1993). Twin studies in medical research. The Lancet vol. 341, (8857) 1418-1419.

Tun RYM, Leslie RDG(1993). Autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes. Saudi Medical Journal vol. 14, (2) 98-102.

Peakman M, Leslie RDG, Vergani D(1993). Immunological studies on type 1 diabetes in identical twins. Archives of Disease in Childhood vol. 69, (1) 97-99.

Smerdon RA, Peakman M, Hussain MJ, Alviggi L, Watkins PJ, Leslie RDG, Vergani D(1993). Increase in simultaneous coexpression of naive and memory lymphocyte markers at diagnosis of IDDM. Diabetes vol. 42, (1) 127-133.

Leslie RDG(1993). Metabolic changes in diabetes. Eye (Basingstoke) vol. 7, (2) 205-208.

Leslie RDG, Carotenuto P, Pozzilli P (1993). New developments in non‐specific and semi‐specific immunosuppression in type I diabetes. Diabetes/Metabolism Reviews. vol. 9, 257-267.

Lo SS, Hawa M, Pyke DA, Leslie RDG(1992). Erratum: Altered Islet Beta-cell function before the onset of Type 1 (insulin-dependent) diabetes mellitus (Diabetologia, Volume 35, Number 3, March 1992 (pp 277-282)). Diabetologia vol. 35, (11)

Lo SSS, Hawa M, Beer SF, Pyke DA, Leslie RDG(1992). Altered islet Beta-cell function before the onset of Type 1 (insulin-dependent) diabetes mellitus. Diabetologia vol. 35, (3) 277-282.

Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF et al.(1992). Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: Studies with identical twins. Diabetes vol. 41, (7) 782-787.

Leslie RDG, Lo S, Millward BA, Honour J, Pyke DA(1991). Decreased growth velocity before IDDM onset. Diabetes vol. 40, (2) 211-216.

Leslie RDG, Pyke DA(1991). Escaping insulin dependent diabetes. British Medical Journal vol. 302, (6785) 1103-1104.

Lo SSS, Tun RYM, Leslie RDG(1991). Non‐genetic Factors Causing Type 1 Diabetes. Diabetic Medicine vol. 8, (7) 609-618.

Lo SSS, Tun RYM, Hawa M, Leslie RDG(1991). Studies of diabetic twins. Diabetes/Metabolism Reviews vol. 7, (4) 223-238.

Beer SF, Heaton DA, Alberti KGMM, Pyke DA, Leslie RDG(1990). Impaired glucose tolerance precedes but does not predict insulin-dependent diabetes mellitus: a study of identical twins. Diabetologia vol. 33, (8) 497-502.

Johnston C, Millward BA, Leslie RDG, Pyke DA, Bottazzo GF(1990). Are thyrogastric autoantibodies associated with an increased susceptibility to developing type 1 (insulin-dependent) diabetes? a study in identical twins. Autoimmunity vol. 6, (3) 195-201.

Peakman M, Hussain MJ, Millward BA, Leslie RDG, Vergani D(1990). Effect of Initiation of Insulin Therapy on T‐lymphocyte Activation in Type 1 Diabetes. Diabetic Medicine vol. 7, (4) 327-330.

Heaton DA, Lazarus NR, Pyke DA, Leslie RDG(1989). B-cell responses to intravenous glucose and glucagon in non-diabetic twins of patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia vol. 32, (11) 814-817.

Johnston C, Millward BA, Hoskins P, Leslie RDG, Bottazzo GF, Pyke DA(1989). Islet-cell antibodies as predictors of the later development of Type 1 (insulin-dependent) diabetes - A study in identical twins. Diabetologia vol. 32, (6) 382-386.

Leslie RDG, Lazarus NR, Vergani D(1989). Aetiology of insulin-dependent diabetes. British Medical Bulletin vol. 45, (1) 58-72.

Leslie RDG, Lazarus NR, Vergani D(1989). Events leading to insulin-dependent diabetes. Clinical Science vol. 76, (2) 119-124.

Hammer MR, John PN, Flynn MD, Bellingham AJ, Leslie RDG(1989). Glycated fibrinogen: A new index of short-term diabetic control. Annals of Clinical Biochemistry vol. 26, (1) 58-62.

Olmos P, A'Hern R, Heaton DA, Millward BA, Risley D, Pyke DA, Leslie RDG(1988). The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins. Diabetologia vol. 31, (10) 747-750.

Heaton DA, Millward BA, Gray IP, Tun Y, Hales CN, Pyke DA, Leslie RDG(1988). Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients. Diabetologia vol. 31, (3) 182-184.

Johnston C, Alviggi L, Millward BA, Leslie RDG, Pyke DA, Vergani D(1988). Alterations in T-lymphocyte subpopulations in type I diabetes. Exploration of genetic influence in identical twins. Diabetes vol. 37, (11) 1484-1488.

Millward A, Hussain MJ, Peakman M, Pyke DA, Leslie RDG, Vergani D(1988). Characterization of islet cell antibody in insulin dependent diabetes: evidence for IgG1 subclass restriction and polyclonality. Clinical and Experimental Immunology vol. 71, (2) 353-356.

Leslie RDG, Ganash A, Volkmann HP, Hanning I, Alberti KGMM(1988). Insensitivity to insulin in offspring of non-insulin dependent diabetic patients. Diabetes, Nutrition and Metabolism - Clinical and Experimental vol. 1, (3) 235-237.

Senaldi G, Millward BA, Hussain MJ, Pyke DA, Leslie RDG, Vergani D(1988). Low serum haemolytic function of the fourth complement component (C4) in insulin dependent diabetes. Journal of Clinical Pathology vol. 41, (10) 1114-1116.

Hussain MJ, Alviggi L, Millward BA, Leslie RDG, Pyke DA, Vergani D(1987). Evidence that the reduced number of natural killer cells in Type 1 (insulin-dependent) diabetes may be genetically determined. Diabetologia vol. 30, (12) 907-911.

Senaldi G, Millward BA, Hussein MJ, Pyke D, Leslie RDG, Vergani D(1987). Complement in Type 1 (insulin-dependent) diabetes. Diabetologia vol. 30, (10)

Heaton DA, Millward BA, Tun Y, Pyke DA, Leslie RDG, Gray P, Hales CN(1987). Evidence of β cell dysfunction which does not lead on to diabetes: A study of identical twins of insulin dependent diabetics. British Medical Journal (Clinical research ed.) vol. 294, (6565) 145-146.

Millward BA, Welsh KI, Leslie RDG, Pyke DA, Demaine AG(1987). T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes. Clinical and Experimental Immunology vol. 70, (1) 152-157.

Ferner RE, Jarrett RJ, Leslie RDG, O'Rahilly SP, Nugent Z, Rudenski AS, Hosker JP, Turner RC(1986). BETA-CELL FUNCTION IN TYPE II DIABETES. The Lancet vol. 328, (8507) 628-629.

Leslie RD(1986). Metabolic abnormalities in children of non-insulin dependent diabetics. British Medical Journal (Clinical research ed.) vol. 293, (6551) 840-842.

Pyke DA, Hoskins PJ, Leslie RD(1985). Monozygotic twins and genetic aspects of diabetes. Journees annuelles de diabetologie de l"Hotel-Dieu121-133.

Leslie RDG, Pyke DA, Denman AM(1985). IMMUNOSUPPRESSIVE THERAPY IN DIABETES. The Lancet vol. 325, (8427)

Wilkin T, Armitage M, Casey C, Pyke DA, Hoskins PJ, Rodier M, Diaz JL, Leslie RDG(1985). VALUE OF INSULIN AUTOANTIBODIES AS SERUM MARKERS FOR INSULIN-DEPENDENT DIABETES MELLITUS. The Lancet vol. 325, (8427) 480-482.

Hoskins PJ, Leslie RDG, Pyke DA(1985). Height at diagnosis of diabetes in children: A study in identical twins. British Medical Journal (Clinical research ed.) vol. 290, (6464) 278-280.

Alviggi L, Hoskins PJ, Pyke DA, Johnston C, Tee DEH, Leslie RDG, Vergani D(1984). PATHOGENESIS OF INSULIN-DEPENDENT DIABETES: A ROLE FOR ACTIVATED T LYMPHOCYTES. The Lancet vol. 324, (8393) 4-6.

Johnston C, Owerbach D, Leslie RDG, Pyke DA, Nerup J(1984). MASON-TYPE DIABETES AND DNA INSERTION POLYMORPHISM. The Lancet vol. 323, (8371)

Leslie RDG(1984). Clinical significance of chlorpropamide-alcohol flushing in NIDDM vasculopathy. Practical Cardiology vol. 10, (12) 79-90.

Wiles PG, Hoskins P, Leslie RDG, Pyke DA(1984). Prevalence of chlorpropamide alcohol flushing. British Medical Journal vol. 288, (6413) 328-329.

Leslie RDG(1983). Causes of insulin dependent diabetes. British Medical Journal vol. 287, (6384) 5-6.

Leslie RDG, Eff C, Barnett AH, Spiliopoulos AJ, Pyke DA, Stubbs WA, Alberti KG(1982). Opiate receptors and the metabolic response to intravenous glucose. Diabete et Metabolisme vol. 8, (3) 235-239.

Leslie RDG, Pyke DA(1982). Diabetic retinopathy in identical twins. Diabetes vol. 31, (1) 19-21.

Harris M, Leslie RDG(1981). Chlorpropamide-alcohol flushing and diabetes - Report of an International Workshop, 13-14 June 1980, Washington, USA. Diabetologia vol. 21, (4) 422-424.

Barnett AH, Leslie RDG, Pyke DA(1981). Chlorpropamide-alcohol flushing and proteinuria in non-insulin-dependent diabetics. British Medical Journal (Clinical research ed.) vol. 282, (6263) 522-523.

Stubbs SM, Leslie RDG, John PN(1981). Fetal macrosomia and maternal diabetic control in pregnancy. British Medical Journal (Clinical research ed.) vol. 282, (6262) 439-440.

Barnett AH, Eff C, Leslie RDG, Pyke DA(1981). Diabetes in identical twins - A study of 200 pairs. Diabetologia vol. 20, (2) 87-93.

Green IC, Perrin D, Pedley KC, Leslie RDG, Pyke DA(1980). Effect of enkephalins and morphine on insulin secretion from isolated rat islets. Diabetologia vol. 19, (2) 158-161.

Leslie RDG, Bellamy D, Pyke DA(1980). Asthma induced by enkephalin. British Medical Journal vol. 280, (6206) 16-18.

Young BJJ, Clark CJM, Hamblin TJ, Mallya RK, Leslie RDG(1979). Anti-keratin antibodies in rheumatoid arthritis. British Medical Journal vol. 2, (6182) 97-99.

Leslie RDG, Pyke DA, John PN, White JM(1979). How quickly can haemoglobin A<inf>1</inf> increase?. British Medical Journal vol. 2, (6181)

Leslie RDG, Barnett AH, Pyke DA(1979). CHLORPROPAMIDE ALCOHOL FLUSHING AND DIABETIC RETINOPATHY. The Lancet vol. 313, (8124) 997-999.

Leslie RDG, Pyke DA, John PN, White JM(1979). FAST GLYCOSYLATION OF HÆMOGLOBIN. The Lancet vol. 313, (8119) 773-774.

Leslie RDG, Pyke DA, Stubbs WA(1979). SENSITIVITY TO ENKEPHALIN AS A CAUSE OF NON-INSULIN DEPENDENT DIABETES. The Lancet vol. 313, (8112) 341-343.

Leslie RDG, Pyke DA(1979). Letter to the editor. Diabetologia vol. 16, (2)

Pyke DA, Leslie RDG(1978). Chlorpropamide-alcohol flushing: A definition of its relation to non-insulin-dependent diabetes. British Medical Journal vol. 2, (6151) 1521-1522.

Leslie RDG, Pyke DA(1978). Chlorpropamide-alcohol flushing: A dominantly inherited trait associated with diabetes. British Medical Journal vol. 2, (6151) 1519-1521.

Leslie RDG, Mackay JD(1978). Intravenous insulin infusion in diabetic emergencies. British Medical Journal vol. 2, (6148)

Leslie RDG, John PN, Pyke DA, White JM(1978). HÆMOGLOBIN A<inf>1</inf> IN DIABETIC PREGNANCY. The Lancet vol. 312, (8097) 958-959.

Essex NL, Leslie R, Mackay JD, Stubbs SM(1978). Regulating blood glucose concentration in diabetes during labour. British Medical Journal vol. 2, (6142)

Leslie RDG, Pyke DA(1978). Chlorpropamide-alcohol flushing and maturity onset diabetes. Diabetologia vol. 15, (3)

Leslie RDG, Pyke DA(1978). Chlorpropamide-induced flushing after alcohol: A genetic marker for a specific type of early onset diabetes?. Quarterly Journal of Medicine vol. 47, (188) 567-568.