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Research

Publications: Prof Thomas MacDonald

Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby- Bell J, Yang F, Lo JW et al. ( 2022 ) . Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy . Nature Communications vol. 13 , ( 1 )
Omer OS, Hertweck A, Roberts LB, Lo JW, Clough JN, Jackson I, Pantazi ED, Irving PM et al. ( 2022 ) . Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease . Cellular and molecular gastroenterology and hepatology vol. 14 , ( 3 ) 625 - 641 .
Roberts KJ, Cubitt MF, Carlton TM, Rodrigues-Duarte L, Maggiore L, Chai R, Clare S, Harcourt K et al. ( 2021 ) . Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease . Scientific Reports vol. 11 , ( 1 )
Papa-Gobbi R, Muglia CI, Rocca A, Curciarello R, Sambuelli AM, Yantorno M, Correa G, Morosi LG et al. ( 2021 ) . Spatiotemporal regulation of galectin-1-induced T-cell death in lamina propria from Crohn’s disease and ulcerative colitis patients . Apoptosis vol. 26 , ( 5-6 ) 323 - 337 .
Mares A, Miah AH, Smith IED, Rackham M, Thawani AR, Cryan J, Haile PA, Votta BJ et al. ( 2020 ) . Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 . Communications Biology vol. 3 , ( 1 )
MacDonald TT, Di Sabatino A ( 2020 ) . T lymphocyte populations within the lamina propria . Principles of Mucosal Immunology ,
Powell N, Pantazi E, Pavlidis P, Tsakmaki A, Li K, Yang F, Parker A, Pin C et al. ( 2020 ) . Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells . Gut vol. 69 , ( 3 ) 578 - 590 .
Curciarello R, Sobande T, Jones S, Giuffrida P, Di Sabatino A, Docena GH, Macdonald TT, Kok K ( 2020 ) . Human neutrophil elastase proteolytic activity in ulcerative colitis favors the loss of function of therapeutic monoclonal antibodies . Journal of Inflammation Research vol. 13 , 233 - 243 .
De la Fuente M, MacDonald TT, Hermoso MA ( 2019 ) . Editorial: Intestinal Homeostasis and Disease: A Complex Partnership Between Immune Cells, Non-Immune Cells, and the Microbiome . Frontiers in Immunology vol. 10 ,
Nurbhai S, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Ray KP, Reckless J, Mohammed H et al. ( 2019 ) . Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients . Scientific Reports vol. 9 , ( 1 )
Haddow JB, Musbahi O, MacDonald TT, Knowles CH ( 2019 ) . Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn's disease-related perianal fistula . World J Gastrointest Pathophysiol vol. 10 , ( 4 ) 42 - 53 .
Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ et al. ( 2019 ) . Discovery of a first-in-class receptor interacting protein 2 (RIP2) kinase specific clinical candidate, 2-((4-(Benzo[ d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate, for the treatment of inflammatory diseases . Journal of Medicinal Chemistry vol. 62 , ( 14 ) 6482 - 6494 .
Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E et al. ( 2019 ) . IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease . Journal of Clinical Investigation vol. 129 , ( 5 ) 1910 - 1925 .
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X et al. ( 2019 ) . Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation . Cell Reports vol. 27 , ( 5 ) 1461 - 1471.e4 .
Reisdorf WC, Xie Q, Zeng X, Xie W, Rajpal N, Hoang B, Burgert ME, Kumar V et al. ( 2019 ) . Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease . PLoS ONE vol. 14 , ( 4 )
Garrido-Mesa N, Schroeder JH, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V et al. ( 2019 ) . T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function . Mucosal Immunology vol. 12 , ( 1 ) 51 - 63 .
Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A, Ortenzi A et al. ( 2019 ) . The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation . Cellular and Molecular Gastroenterology and Hepatology vol. 7 , ( 2 ) 457 - 473 .
Scott Crowe J, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J et al. ( 2018 ) . Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease . Scientific Reports vol. 8 , ( 1 )
Díaz-Jiménez D, Núñez L, De La Fuente M, Dubois-Camacho K, Sepúlveda H, Montecino M, Torres-Riquelme A, García-González P et al. ( 2017 ) . A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis . Scientific Reports vol. 7 , ( 1 )
Curciarello R, Docena GH, MacDonald TT ( 2017 ) . The Role of Cytokines in the Fibrotic Responses in Crohn's Disease . Frontiers in Medicine vol. 4 , 126 - 126 .
Powell N, MacDonald TT ( 2017 ) . Recent advances in gut immunology . Parasite Immunology vol. 39 , ( 6 )
Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J et al. ( 2017 ) . Homeostasis of the gut barrier and potential biomarkers . American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 312 , ( 3 ) G171 - G193 .
Biancheri P, MacDonald TT ( 2017 ) . Matrix metalloproteinases . Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach: Second Edition ,
Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA et al. ( 2017 ) . Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases . J Med Chem vol. 60 , ( 4 ) 1247 - 1261 .
Foster M, Biancheri P, Fyfe M, MacDonald T, Rowley A, Sirohi S, Solanke Y, Webber S et al. ( 2017 ) . The pharmacological profile of TOP1288, a narrow spectrum kinase inhibitor in clinical development as an anti-inflammatory treatment for ulcerative colitis . JOURNAL OF CROHNS & COLITIS . vol. 11 , S95 - S95 .
Bron PA, Kleerebezem M, Brummer R-J, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM ( 2017 ) . Can probiotics modulate human disease by impacting intestinal barrier function? . Br J Nutr vol. 117 , ( 1 ) 93 - 107 .
Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, Macdonald TT, Lindsay JO, Stagg AJ ( 2017 ) . Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease . Mucosal Immunology vol. 10 , ( 1 ) 184 - 193 .
König J, Wells J, Cani PD, García-Ródenas CL, MacDonald T, Mercenier A, Whyte J, Troost F et al. ( 2016 ) . Human intestinal barrier function in health and disease . Clinical and Translational Gastroenterology vol. 7 , ( 10 )
Muthas D, Reznichenko A, Balendran CA, Böttcher G, Clausen IG, Kärrman Mårdh C, Ottosson T, Uddin M et al. ( 2016 ) . Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications . Scand J Gastroenterol vol. 52 , ( 2 ) 125 - 135 .
Biancheri P, Foster MR, Fyfe MCT, Macdonald TT, Sirohi S, Solanke Y, Wood E, Rowley A et al. ( 2016 ) . Effect of narrow spectrum versus selective kinase inhibitors on the intestinal proinflammatory immune response in ulcerative colitis . Inflammatory Bowel Diseases vol. 22 , ( 6 ) 1306 - 1315 .
Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R, Charnley AK, Lakdawala AS et al. ( 2016 ) . The Identification and Pharmacological Characterization of 6-( tert -Butylsulfonyl)- N -(5-fluoro-1 H -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase . Journal of Medicinal Chemistry vol. 59 , ( 10 ) 4867 - 4880 .
Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E et al. ( 2016 ) . Developing in vitro expanded CD45RA<sup>+</sup> regulatory T cells as an adoptive cell therapy for Crohn's disease . Gut vol. 65 , ( 4 ) 584 - 594 .
Biancheri P, Sabatino AD, Rescigno M, Giuffrida P, Fornasa G, Tsilingiri K, Pender SLF, Papadia C et al. ( 2016 ) . Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with celiac disease . Gut vol. 65 , ( 10 ) 1670 - 1680 .
De la Fuente M, MacDonald TT, Hermoso MA ( 2015 ) . The IL-33/ST2 axis: Role in health and disease . Cytokine and Growth Factor Reviews vol. 26 , ( 6 ) 615 - 623 .
Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L et al. ( 2015 ) . Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients with Inflammatory Bowel Disease . Gastroenterology vol. 149 , ( 6 ) 1564 - 1574.e3 .
Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F et al. ( 2015 ) . Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation . Gastroenterology vol. 149 , ( 2 ) 456 - 467.e15 .
De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P et al. ( 2015 ) . Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth . Oncogene vol. 34 , ( 27 ) 3493 - 3503 .
Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N ( 2015 ) . The unusual suspects - Innate lymphoid cells as novel therapeutic targets in IBD . Nature Reviews Gastroenterology and Hepatology vol. 12 , ( 5 ) 271 - 283 .
Biancheri P, Di Sabatino A, Curciarello R, Ammoscato F, Corazza GR, Lindsay JO, MacDonald TT ( 2015 ) . Mo1724 Interleukin-17A Homodimer Reduces Pro-Inflammatory Cytokine Production by Inflammatory Bowel Disease Mucosa Cultured Ex Vivo . Gastroenterology vol. 148 , ( 4 ) s - 695 .
Di Sabatino A, Giuffrida P, Fornasa G, Salvatore C, Broglia F, Pasini A, Ammoscato F, Rescigno M et al. ( 2015 ) . THYMIC STROMAL LYMPHOPOIETIN MODULATES TISSUE REMODELLING AND REPAIR IN NORMAL AND INFLAMED GUT . DIGESTIVE AND LIVER DISEASE . vol. 47 , E182 - E182 .
de Simone V, Ronchetti G, Franzè E, Colantoni A, Ortenzi A, Fantini MC, Rizzo A, Sica GS et al. ( 2015 ) . Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis . Oncotarget vol. 6 , ( 12 ) 9908 - 9923 .
Caruso R, Marafini I, Franzè E, Stolfi C, Zorzi F, Monteleone I, Caprioli F, Colantoni A et al. ( 2014 ) . Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut . Mucosal Immunol vol. 7 , ( 6 ) 1467 - 1479 .
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al. ( 2014 ) . In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts . Clin Sci (Lond) vol. 127 , ( 5 ) 341 - 350 .
Vossenkämper A, Hundsrucker C, Page K, van Maurik A, Sanders TJ, Stagg AJ, Das L, MacDonald TT ( 2014 ) . A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease . Gastroenterology vol. 147 , ( 1 ) 172 - 183 .
Rizzo A, De Mare V, Rocchi C, Stolfi C, Colantoni A, Neurath MF, Macdonald TT, Pallone F et al. ( 2014 ) . Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells . Carcinogenesis vol. 35 , ( 7 ) 1536 - 1546 .
Cupi ML, Sarra M, Marafini I, Monteleone I, Franzè E, Ortenzi A, Colantoni A, Sica G et al. ( 2014 ) . Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities . J Immunol vol. 192 , ( 12 ) 6083 - 6091 .
Caruso R, Marafini I, Sedda S, Del Vecchio Blanco G, Giuffrida P, MacDonald TT, Corazza GR, Pallone F et al. ( 2014 ) . Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients . CLINICAL SCIENCE vol. 126 , ( 5-6 ) 451 - 458 .
Giuffrida P, Biancheri P, MacDonald TT ( 2014 ) . Proteases and small intestinal barrier function in health and disease . Curr Opin Gastroenterol vol. 30 , ( 2 ) 147 - 153 .
Stolfi C, De Simone V, Colantoni A, Franzè E, Ribichini E, Fantini MC, Caruso R, Monteleone I et al. ( 2014 ) . A functional role for Smad7 in sustaining colon cancer cell growth and survival . Cell Death Dis vol. 5 ,
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A et al. ( 2014 ) . Absence of a role for interleukin-13 in inflammatory bowel disease . Eur J Immunol vol. 44 , ( 2 ) 370 - 385 .
Kok K, Curciarello R, Giuffrida P, Joshi N, Biancheri P, MacDonald T ( 2014 ) . P054 Interactions between neutrophil elastase and biologics in IBD . Journal of Crohn's and Colitis vol. 8 ,
Biancheri P, Giuffrida P, Docena GH, MacDonald TT, Corazza GR, Di Sabatino A ( 2014 ) . The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut . Cytokine Growth Factor Rev vol. 25 , ( 1 ) 45 - 55 .
Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP et al. ( 2014 ) . Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α . Gut vol. 63 , ( 1 ) 96 - 104 .
Curciarello R, Steele A, Cooper D, MacDonald TT, Kruidenier L, Kudo T ( 2014 ) . The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection . PLoS One vol. 9 , ( 9 )
Biancheri P, Powell N, Monteleone G, Lord G, MacDonald TT ( 2013 ) . The challenges of stratifying patients for trials in inflammatory bowel disease . Trends Immunol vol. 34 , ( 11 ) 564 - 571 .
Sarra M, Cupi ML, Bernardini R, Ronchetti G, Monteleone I, Ranalli M, Franzè E, Rizzo A et al. ( 2013 ) . IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism . Hepatology vol. 58 , ( 4 ) 1436 - 1450 .
McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ et al. ( 2013 ) . Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells . J Immunol vol. 191 , ( 5 ) 2752 - 2763 .
Vossenkämper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD et al. ( 2013 ) . A role for gut-associated lymphoid tissue in shaping the human B cell repertoire . J Exp Med vol. 210 , ( 9 ) 1665 - 1674 .
Biancheri P, Pender SL, Ammoscato F, Giuffrida P, Sampietro G, Ardizzone S, Ghanbari A, Curciarello R et al. ( 2013 ) . The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis . Fibrogenesis Tissue Repair vol. 6 , ( 1 )
Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C, Vidali F, MacDonald TT et al. ( 2013 ) . Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx . INTERNAL AND EMERGENCY MEDICINE vol. 8 , ( 4 ) 317 - 325 .
Biancheri P, Di Sabatino A, Fornasa G, Giuffrida P, Rovedatti L, Pasini A, Ammoscato F, MacDonald TT et al. ( 2013 ) . Thymic Stromal Lymphopoietin Is Primarily Reduced in Untreated Celiac Disease Mucosa . GASTROENTEROLOGY . vol. 144 , S242 - S242 .
Franzè E, Caruso R, Stolfi C, Sarra M, Cupi ML, Ascolani M, Sedda S, Antenucci C et al. ( 2013 ) . High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases . Inflamm Bowel Dis vol. 19 , ( 3 ) 501 - 511 .
Biancheri P, Di Sabatino A, Gough P, Votta B, Foley K, Vossenkaemper A, Bertin J, Corazza GR et al. ( 2013 ) . OC.07.2 SELECTIVE INHIBITION OF RIP2 KINASE ACTIVITY REDUCES PRO-INFLAMMATORY CYTOKINE PRODUCTION IN INFLAMMATORY BOWEL DISEASE MUCOSA . Digestive and Liver Disease vol. 45 ,
Biancheri P, Di Sabatino A, Rovedatti L, Giuffrida P, Calarota SA, Vetrano S, Vidali F, Pasini A et al. ( 2013 ) . Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease . Inflamm Bowel Dis vol. 19 , ( 2 ) 259 - 264 .
Kok K, Curciarello R, Biancheri P, Langmead L, MacDonald T ( 2013 ) . P019 The role of human neutrophil elastase and its inhibitor elafin in ulcerative colitis . Journal of Crohn's and Colitis vol. 7 ,
Biancheri P, Nijhuis A, Di Sabatino A, Lai C, Ghosh A, MacDonald TT, Corazza GR, Lindsay J et al. ( 2013 ) . P057 Micro-RNA expression profiling identifies miR-29b as a relevant pro-fibrogenic factor in Crohn's disease intestinal strictures . Journal of Crohn's and Colitis vol. 7 ,
McCarthy N, Hedin C, Bashir Z, Vossenkämper A, Giles E, Sanders T, Whelan K, MacDonald T et al. ( 2013 ) . P066 Human intestinal Vδ2+ T-cells promote mucosal inflammation in Crohn's disease and are selectively ablated by azathioprine therapy . Journal of Crohn's and Colitis vol. 7 , s35 - s36 .
Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT ( 2013 ) . Proteases and the gut barrier . CELL AND TISSUE RESEARCH vol. 351 , ( 2 ) 269 - 280 .
Monteleone I, Federici M, Sarra M, Franze E, Casagrande V, Zorzi F, Cavalera M, Rizzo A et al. ( 2012 ) . Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine . GASTROENTEROLOGY vol. 143 , ( 5 ) 1277 - + .
MacDonald TT, Biancheri P, Sarra M, Monteleone G ( 2012 ) . What's the next best cytokine target in IBD? . Inflamm Bowel Dis vol. 18 , ( 11 ) 2180 - 2189 .
Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A et al. ( 2012 ) . The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells . Immunity vol. 37 , ( 4 ) 674 - 684 .
Monteleone I, MacDonald TT, Pallone F, Monteleone G ( 2012 ) . The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis . CURRENT OPINION IN GASTROENTEROLOGY vol. 28 , ( 4 ) 310 - 313 .
Powell N, Stolarczyk E, Canavan JB, Marks E, MacDonald TT, Lord G ( 2012 ) . T-bet Regulates Cytokine Expression by Intestinal Innate Lymphoid Cells . GASTROENTEROLOGY . vol. 142 , S175 - S176 .
Biancheri P, Ammoscato F, Di Sabatino A, Joe-Njoku I, Rovedatti L, Corazza GR, MacDonald TT ( 2012 ) . Tu1895 Does Interleukin (IL)-13 Have a Role in Sustaining the Mucosal PRO-Inflammatory Immune Response in Ulcerative Colitis and in Promoting Intestinal Fibrogenesis in Crohn's Disease? . Gastroenterology vol. 142 , ( 5 ) s - 872 .
Biancheri P, Nijhuis A, Lai C, Ghosh A, Feakins R, Chan C, Di Sabatino A, Corazza GR et al. ( 2012 ) . Tu1915 Differential MicroRNA Expression Profiles in Crohn's Disease Strictured Versus Non-Strictured Intestine . Gastroenterology vol. 142 , ( 5 ) s - 877 .
Gough P, Votta B, Casillas L, Haile P, Lipshutz D, Desai B, Swift B, Capriotti CA et al. ( 2012 ) . Tu1921 Selective Inhibitors of RIP2 Kinase Activity Reduce PRO-Inflammatory Cytokine Production in IBD Mucosal Biopsy Cultures and Inflammation in Murine TNBS-Induced Colitis . Gastroenterology vol. 142 , ( 5 ) s - 878 .
Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR ( 2012 ) . Recent advances in understanding ulcerative colitis . INTERNAL AND EMERGENCY MEDICINE vol. 7 , ( 2 ) 103 - 111 .
Canavan JB, Afzali B, Scotta C, Fazekasova H, Edozie FC, Macdonald TT, Hernandez-Fuentes MP, Lombardi G et al. ( 2012 ) . A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy . BLOOD vol. 119 , ( 8 ) E57 - E66 .
Di Sabatino A, Biancheri P, Rovedatti L, MacDonald TT, Corazza GR ( 2012 ) . New pathogenic paradigms in inflammatory bowel disease . INFLAMMATORY BOWEL DISEASES vol. 18 , ( 2 ) 368 - 371 .
MacDonald TT, Harper JI, Kelsell DP ( 2012 ) . Inflammatory Bowel Disease and ADAM17 Deletion REPLY . NEW ENGLAND JOURNAL OF MEDICINE vol. 366 , ( 2 ) 190 - 190 .
Stolfi C, Pallone F, Macdonald TT, Monteleone G ( 2012 ) . Interleukin-21 in cancer immunotherapy Friend or foe? . ONCOIMMUNOLOGY vol. 1 , ( 3 ) 351 - 354 .
MacDonald TT, Vossenkaemper A, Fantini M, Monteleone G ( 2012 ) . Reprogramming the immune system in IBD . Dig Dis vol. 30 , ( 4 ) 392 - 395 .
Rizzo A, Waldner MJ, Stolfi C, Sarra M, Fina D, Becker C, Neurath MF, Macdonald TT et al. ( 2011 ) . Smad7 Expression in T cells Prevents Colitis- Associated Cancer . CANCER RESEARCH vol. 71 , ( 24 ) 7423 - 7432 .
Monteleone G, Pallone F, MacDonald TT ( 2011 ) . Emerging immunological targets in inflammatory bowel disease . CURRENT OPINION IN PHARMACOLOGY vol. 11 , ( 6 ) 640 - 645 .
Stolfi C, Rizzo A, Franze E, Rotondi A, Fantini MC, Sarra M, Caruso R, Monteleone I et al. ( 2011 ) . Involvement of interleukin-21 in the regulation of colitis-associated colon cancer . J EXP MED vol. 208 , ( 11 ) 2279 - 2290 .
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F et al. ( 2011 ) . Inflammatory skin and bowel disease linked to ADAM17 deletion . N Engl J Med vol. 365 , ( 16 ) 1502 - 1508 .
Vossenkamper A, Fikree A, Fairclough PD, Aziz Q, MacDonald TT ( 2011 ) . Colonic Lymphoid Nodular Hyperplasia in an Adolescent . Journal of Pediatric Gastroenterology and Nutrition vol. 53 , ( 6 ) 684 - 686 .
Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E et al. ( 2011 ) . The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease . MUCOSAL IMMUNOL vol. 4 , ( 5 ) 574 - 583 .
MacDonald TT, Bell I, Monteleone G ( 2011 ) . The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease . Biochem Soc Trans vol. 39 , ( 4 ) 1061 - 1066 .
Monteleone I, Rizzo A, Sarra M, Sica G, Sileri P, Biancone L, MacDonald TT, Pallone F et al. ( 2011 ) . Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract . GASTROENTEROLOGY vol. 141 , ( 1 ) 237 - U324 .
Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E et al. ( 2011 ) . Erratum: The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease (Mucosal Immunology (2011) DOI: 10.1038 / mi.2011.18)) . Mucosal Immunology vol. 4 , ( 4 )
Macdonald TT ( 2011 ) . New cytokine targets in inflammatory bowel disease . Gastroenterol Hepatol (N Y) vol. 7 , ( 7 ) 474 - 476 .
Vossenkämper A, Macdonald TT, Marchès O ( 2011 ) . Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system . J Inflamm (Lond) vol. 8 ,
Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR, MacDonald TT ( 2011 ) . Fibroblast activation protein expression in Crohn's disease strictures . Inflamm Bowel Dis vol. 17 , ( 5 ) 1251 - 1253 .
Sarra M, Caruso R, Cupi ML, Monteleone I, Stolfi C, Campione E, Diluvio L, Mazzotta A et al. ( 2011 ) . IL-21 Promotes Skin Recruitment of CD4(+) Cells and Drives IFN-gamma-Dependent Epidermal Hyperplasia . J IMMUNOL vol. 186 , ( 9 ) 5435 - 5442 .
MacDonald TT, Monteleone I, Fantini MC, Monteleone G ( 2011 ) . Regulation of homeostasis and inflammation in the intestine . Gastroenterology vol. 140 , ( 6 ) 1768 - 1775 .
Fina D, Franze E, Rovedatti L, Corazza GR, Biancone L, Sileri PP, Sica G, MacDonald TT et al. ( 2011 ) . Interleukin-25 production is differently regulated by TNF-alpha and TGF-beta 1 in the human gut . MUCOSAL IMMUNOL vol. 4 , ( 2 ) 239 - 244 .
Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M, Danese S, MacDonald TT et al. ( 2011 ) . Involvement of CD40-CD40 Ligand in Uncomplicated and Refractory Celiac Disease . AM J GASTROENTEROL vol. 106 , ( 3 ) 519 - 527 .
Di Sabatino A, Calarota SA, Vidali F, MacDonald TT, Corazza GR ( 2011 ) . Role of IL-15 in immune-mediated and infectious diseases . CYTOKINE GROWTH F R vol. 22 , ( 1 ) 19 - 33 .
Monteleone G, Pallone F, MacDonald TT, Chimenti S, Costanzo A ( 2011 ) . Psoriasis: from pathogenesis to novel therapeutic approaches . CLIN SCI vol. 120 , ( 1-2 ) 1 - 11 .
MacDonald TT, Bell I, Monteleone G ( 2010 ) . Cytokine regulation of gut inflammation in IBD . Inflammatory Bowel Disease Monitor vol. 10 , ( 4 ) 111 - 116 .
Monteleone G, Pallone F, MacDonald TT ( 2010 ) . Interleukin-25: A two-edged sword in the control of immune-inflammatory responses . CYTOKINE GROWTH F R vol. 21 , ( 6 ) 471 - 475 .
Macdonald TT ( 2010 ) . Inside the microbial and immune labyrinth: totally gutted . Nat Med vol. 16 , ( 11 ) 1194 - 1195 .
Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L, Ubezio C, Massari A et al. ( 2010 ) . Peripheral Regulatory T Cells and Serum Transforming Growth Factor-beta: Relationship with Clinical Response to Infliximab in Crohn's Disease . INFLAMM BOWEL DIS vol. 16 , ( 11 ) 1891 - 1897 .
Powell N, Canavan JB, MacDonald TT, Lord GM ( 2010 ) . Transcriptional regulation of the mucosal immune system mediated by T-bet . Mucosal Immunol vol. 3 , ( 6 ) 567 - 577 .
Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NAB, Knowles CH, Lee K, Shanahan F et al. ( 2010 ) . Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease . Clin Exp Immunol vol. 162 , ( 1 ) 108 - 115 .
Sarra M, Pallone F, MacDonald TT, Monteleone G ( 2010 ) . IL-23/IL-17 Axis in IBD . INFLAMM BOWEL DIS vol. 16 , ( 10 ) 1808 - 1813 .
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al. ( 2010 ) . Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE . J Immunol vol. 185 , ( 7 ) 4118 - 4127 .
Günther U, Bateman AC, Beattie RM, Bauer M, MacDonald TT, Kaskas BA ( 2010 ) . Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease . Histopathology vol. 57 , ( 3 ) 427 - 435 .
Sarra M, Monteleone I, Stolfi C, Fantini MC, Sileri P, Sica G, Tersigni R, Macdonald TT et al. ( 2010 ) . Interferon-gamma-expressing Cells Are a Major Source of Interleukin-21 in Inflammatory Bowel Diseases . INFLAMM BOWEL DIS vol. 16 , ( 8 ) 1332 - 1339 .
MacDonald TT, Bell I ( 2010 ) . Probiotics and the immune response to vaccines . Proc Nutr Soc vol. 69 , ( 3 ) 442 - 446 .
MacDonald TT ( 2010 ) . Cytokine regulation of intestinal epithelial cell proliferation . Expert Rev Clin Immunol vol. 6 , ( 4 ) 531 - 535 .
Epstein J, Sanderson IR, Macdonald TT ( 2010 ) . Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies . Br J Nutr vol. 103 , ( 11 ) 1545 - 1557 .
Macdonald TT, Monteleone G ( 2010 ) . Adaptive Immunity: Effector and Inhibitory Cytokine Pathways in Gut Inflammation . Inflammatory Bowel Disease: Translating basic science into clinical practice ,
Sarra M, Pallone F, Macdonald TT, Monteleone G ( 2010 ) . Targeting Interleukin-21 in Immune-Mediated Pathologies . CURR DRUG TARGETS vol. 11 , ( 5 ) 645 - 649 .
Epstein J, Docena G, MacDonald TT, Sanderson IR ( 2010 ) . Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease . Br J Nutr vol. 103 , ( 6 ) 824 - 832 .
Monteleone I, Sarra M, Blanco GDV, Paoluzi OA, Franze E, Fina D, Fabrizi A, MacDonald TT et al. ( 2010 ) . Characterization of IL-17A-Producing Cells in Celiac Disease Mucosa . J IMMUNOL vol. 184 , ( 4 ) 2211 - 2218 .
Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR ( 2010 ) . Cancer immunoediting and "spontaneous" tumor regression . Pathol Res Pract vol. 206 , ( 1 ) 1 - 8 .
Stolfi C, Sarra M, Caruso R, Fantini MC, Fina D, Pellegrini R, Palmieri G, MacDonald TT et al. ( 2010 ) . Inhibition of Colon Carcinogenesis by 2-Methoxy-5-Amino-N-Hydroxybenzamide, a Novel Derivative of Mesalamine . GASTROENTEROLOGY vol. 138 , ( 1 ) 221 - 230 .
MacDonald TT ( 2010 ) . News Highlights . Mucosal Immunology vol. 3 , ( 1 ) 2 - 3 .
Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza GR, Monteleone G et al. ( 2009 ) . Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease . Gut vol. 58 , ( 12 ) 1629 - 1636 .
MacDonald TT, Di Sabatino A ( 2009 ) . The immunologic basis for gastrointestinal food allergy . Curr Opin Gastroenterol vol. 25 , ( 6 ) 521 - 526 .
Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM, Pender SL, MacDonald TT ( 2009 ) . CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 production in patients with inflammatory bowel disease . J CROHNS COLITIS vol. 3 , ( 3 ) 175 - 182 .
Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L, Giustizieri ML, Pacciani V et al. ( 2009 ) . Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis . NAT MED vol. 15 , ( 9 ) 1013 - 1015 .
Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P, Rovedatti L, Corazza GR, Macdonald TT et al. ( 2009 ) . Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab . Eur J Gastroenterol Hepatol vol. 21 , ( 9 ) 1049 - 1055 .
Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD, Biancheri P, Leakey NAB et al. ( 2009 ) . Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease . J Immunol vol. 183 , ( 5 ) 3454 - 3462 .
MacDonald TT, Vossenkamper A, Di Sabatino A ( 2009 ) . Antigen presenting cells and T cell interactions in the gastrointestinal tract . Mol Nutr Food Res vol. 53 , ( 8 ) 947 - 951 .
Monteleone G, Pallone F, Macdonald TT ( 2009 ) . Interleukin-21 as a new therapeutic target for immune-mediated diseases . TRENDS PHARMACOL SCI vol. 30 , ( 8 ) 441 - 447 .
Caruso R, Sarra M, Stolfi C, Rio A, Fina D, Fantini MC, Pallone F, MacDonald TT et al. ( 2009 ) . Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut . GASTROENTEROLOGY vol. 136 , ( 7 ) 2270 - 2279 .
Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NAB, Picariello L, Cazzola P et al. ( 2009 ) . Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures . Gut vol. 58 , ( 6 ) 777 - 789 .
Di Sabatino A, Rovedatti L, Rosado MM, Carsetti R, Corazza GR, MacDonald TT ( 2009 ) . Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood . Hum Pathol vol. 40 , ( 5 ) 699 - 704 .
Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G ( 2009 ) . Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3 . Blood vol. 113 , ( 15 ) 3512 - 3519 .
Monteleone G, Pallone F, Macdonald TT ( 2009 ) . Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease . CYTOKINE GROWTH F R vol. 20 , ( 2 ) 185 - 191 .
Fantini MC, Rizzo A, Fina D, Caruso R, Sarra M, Stolfi C, Becker C, Macdonald TT et al. ( 2009 ) . Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression . Gastroenterology vol. 136 , ( 4 ) 1308 - e3 .
Chuang S-L, Hayes PJ, Ogundipe E, Haddad M, MacDonald TT, Fell JM ( 2009 ) . Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis . Pediatr Allergy Immunol vol. 20 , ( 1 ) 45 - 52 .
Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD et al. ( 2008 ) . Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut . Infect Immun vol. 76 , ( 11 ) 4804 - 4813 .
Monteleone G, Boirivant M, Pallone F, MacDonald TT ( 2008 ) . TGF-beta1 and Smad7 in the regulation of IBD . Mucosal Immunol . vol. 1 Suppl 1 , S50 - S53 .
Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S ( 2008 ) . The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium . Infect Immun vol. 76 , ( 11 ) 4978 - 4988 .
Fina D, Pallone F, Macdonald TT, Monteleone G ( 2008 ) . Role of neutrophil recruitment in the amelioration of experimental colitis by genetic ablation of interleukin-21 - Reply . GASTROENTEROLOGY vol. 135 , ( 4 ) 1426 - 1427 .
MacDonald TT ( 2008 ) . Round table discussion: Host immune system and commensal flora as the stimulus to the gut . International Journal of Probiotics and Prebiotics . vol. 3 , 147 - 148 .
Di Sabatino A, Miceli E, Dhaliwal W, Biancheri P, Salerno R, Cantoro L, Vanoli A, De Vincenzi M et al. ( 2008 ) . Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease . Am J Clin Pathol vol. 130 , ( 1 ) 34 - 42 .
Fina D, Sarra M, Caruso R, Del Vecchio Blanco G, Pallone F, MacDonald TT, Monteleone G ( 2008 ) . Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease . Gut vol. 57 , ( 7 ) 887 - 892 .
MacDonald TT ( 2008 ) . The gut is still the biggest lymphoid organ in the body . MUCOSAL IMMUNOL vol. 1 , ( 4 ) 246 - 247 .
Monteleone G, Pallone F, MacDonald TT ( 2008 ) . Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses . Trends Immunol vol. 29 , ( 6 ) 290 - 294 .
Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NAB, Corazza GR, Monteleone G et al. ( 2008 ) . Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa . Gut vol. 57 , ( 5 ) 605 - 612 .
Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al. ( 2008 ) . Autocrine regulation of interleukin-21 production in human peripheral blood and intestinal T lymphocytes . GASTROENTEROLOGY vol. 134 , ( 4 ) A2 - A2 .
Di Sabatino A, Rovedatti L, Biancheri P, Rosado M, Cantoro L, Carsetti R, Corazza GR, MacDonald TT ( 2008 ) . Mucosal addressin cell adhesion molecule-1 in celiac disease . GASTROENTEROLOGY vol. 134 , ( 4 ) A519 - A519 .
Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I et al. ( 2008 ) . Regulation of gut inflammation and th17 cell response by interleukin-21 . Gastroenterology vol. 134 , ( 4 ) 1038 - 1048 .
Fantini MC, Rizzo A, Fina D, Sarra M, Caruso R, Becker C, Pallone F, Macdonald TT et al. ( 2008 ) . T cell-specific Smad7 over-expression reduces regulatory T cell-mediated control of colitis . GASTROENTEROLOGY vol. 134 , ( 4 ) A72 - A73 .
Fantini MC, Monteleone G, MacDonald TT ( 2008 ) . IL-21 comes of age as a regulator of effector T cells in the gut . Mucosal Immunol vol. 1 , ( 2 ) 110 - 115 .
Caprioli F, Sarra M, Caruso R, Stolfi C, Fina D, Sica G, MacDonald TT, Pallone F et al. ( 2008 ) . Autocrine regulation of IL-21 production in human T lymphocytes . J Immunol vol. 180 , ( 3 ) 1800 - 1807 .
Caruso R, Fina D, Paoluzi OA, Del Vecchio Blanco G, Stolfi C, Rizzo A, Caprioli F, Sarra M et al. ( 2008 ) . IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa . Eur J Immunol vol. 38 , ( 2 ) 470 - 478 .
Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SLF, Goggin PM, MacDonald TT ( 2008 ) . Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease . Inflamm Bowel Dis . vol. 14 , 195 - 203 .
Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM, MacDonald T ( 2008 ) . Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease . Inflamm Bowel Dis vol. 14 , ( 2 ) 195 - 203 .
Blumberg RS, MacDonald TT ( 2008 ) . Mucosal immunology: a frontier no longer . MUCOSAL IMMUNOL vol. 1 , ( 1 ) 3 - 3 .
Sengupta N, MacDonald TT ( 2007 ) . The role of matrix metalloproteinases in stromal/epithelial interactions in the gut . Physiology (Bethesda) vol. 22 , 401 - 409 .
Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F et al. ( 2007 ) . IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells . Eur J Immunol vol. 37 , ( 11 ) 3155 - 3163 .
Fantini MC, Monteleone G, Macdonald TT ( 2007 ) . New players in the cytokine orchestra of inflammatory bowel disease . Inflamm Bowel Dis vol. 13 , ( 11 ) 1419 - 1423 .
Macdonald TT, Domizio P ( 2007 ) . Autistic enterocolitis: is it a histopathological entity? . Histopathology vol. 51 , ( 4 ) 552 - 553 .
Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L et al. ( 2007 ) . Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease . Gastroenterology vol. 133 , ( 4 ) 1175 - 1187 .
Di Sabatino A, Pender SLF, Jackson CL, Prothero JD, Gordon JN, Picariello L, Rovedatti L, Docena G et al. ( 2007 ) . Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies . Gastroenterology vol. 133 , ( 1 ) 137 - 149 .
Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F et al. ( 2007 ) . IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis . J Immunol vol. 178 , ( 9 ) 5957 - 5965 .
Lottaz D, Buri C, Monteleone G, Rösmann S, Macdonald TT, Sanderson IR, Sterchi EE ( 2007 ) . Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease . Biol Chem vol. 388 , ( 3 ) 337 - 341 .
MacDonald TT, Domizio P ( 2007 ) . Autistic enterocolitis; is it a histopathological entity? . Histopathology vol. 50 , ( 3 ) 371 - 379 .
Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, Pallone F, Monteleone G ( 2007 ) . IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes . J Immunol vol. 178 , ( 2 ) 732 - 739 .
Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G et al. ( 2007 ) . A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells . Gastroenterology vol. 132 , ( 1 ) 166 - 175 .
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F et al. ( 2006 ) . Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21 . Gut vol. 55 , ( 12 ) 1774 - 1780 .
Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A et al. ( 2006 ) . Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis . Gastroenterology vol. 131 , ( 6 ) 1786 - 1798 .
Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G ( 2006 ) . In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium . Infect Immun vol. 74 , ( 9 ) 5391 - 5396 .
Pender SLF, Li CKF, Di Sabatino A, MacDonald TT, Buckley MG ( 2006 ) . Role of macrophage metalloelastase in gut inflammation . Ann N Y Acad Sci . vol. 1072 , 386 - 388 .
Caruso R, Pallone F, Fina D, Gioia V, Peluso I, Caprioli F, Stolfi C, Perfetti A et al. ( 2006 ) . Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation . Am J Pathol vol. 169 , ( 1 ) 268 - 278 .
MacDonald TT, Di Sabatino A ( 2006 ) . The exposure of infants to Lactobacillus rhamnosus GG in Finland . J Pediatr Gastroenterol Nutr vol. 42 , ( 5 ) 476 - 478 .
MacDonald TT ( 2006 ) . The significance of ileocolonic lymphoid nodular hyperplasia in children with autistic spectrum disorder . Eur J Gastroenterol Hepatol vol. 18 , ( 5 ) 569 - 571 .
Fina D, Peluso I, Caruso R, Valentina G, Stolfi C, MacDonald TT, Pallone F, Monteleone G ( 2006 ) . Regulation of matrix metalloproteinases synthesis by interleukin-21 in human intestinal fibroblasts . INFLAMMATORY BOWEL DISEASES . vol. 12 , S24 - S24 .
MacDonald TT ( 2006 ) . Decoy receptor springs to life and eases fibrosis . Nat Med vol. 12 , ( 1 ) 13 - 14 .
MacDonald TT, Di Sabatino A, Gordon JN ( 2006 ) . Erratum: Immunopathogenesis of Crohn's disease (Journal of Parental and Eternal Nutrition (July-August 2005) 29, Suppl 4 (S118-S124)) . Journal of Parenteral and Enteral Nutrition vol. 30 , ( 1 )
Kruidenier L, MacDonald TT, Collins JE, Pender SLF, Sanderson IR ( 2006 ) . Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells . Gastroenterology vol. 130 , ( 1 ) 127 - 136 .
MacDonald TT, Monteleone G ( 2006 ) . Overview of role of the immune system in the pathogenesis of inflammatory bowel disease . Adv Exp Med Biol vol. 579 , 98 - 107 .
Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S ( 2005 ) . Citrobacter rodentium of mice and man . Cell Microbiol vol. 7 , ( 12 ) 1697 - 1706 .
MacDonald TT, Monteleone G ( 2005 ) . Human gut-associated lymphoid tissues . Mucosal Immunology, Two-Volume Set ,
MacDonald TT, Miller RD ( 2005 ) . Phylogeny of the gut-associated lymphoid tissue (GALT) . Mucosal Immunology, Two-Volume Set ,
Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G et al. ( 2005 ) . Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease . Gastroenterology vol. 129 , ( 5 ) 1420 - 1429 .
MacDonald TT, Gordon JN ( 2005 ) . Bacterial regulation of intestinal immune responses . Gastroenterol Clin North Am vol. 34 , ( 3 ) 401 - viii .
Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE ( 2005 ) . Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells . Lab Invest vol. 85 , ( 9 ) 1139 - 1162 .
Gordon JN, MacDonald TT ( 2005 ) . Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease . GUT vol. 54 , ( 9 ) 1213 - 1215 .
Pender SL-F, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, MacDonald TT ( 2005 ) . Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model . Gut vol. 54 , ( 8 ) 1114 - 1120 .
MacDonald TT, Di Sabatino A, Gordon JN ( 2005 ) . Immunopathogenesis of Crohn's disease . JPEN J Parenter Enteral Nutr vol. 29 , ( 4 Suppl ) S118 - S124 .
Gordon JN, Di Sabatino A, Macdonald TT ( 2005 ) . The pathophysiologic rationale for biological therapies in inflammatory bowel disease . Curr Opin Gastroenterol vol. 21 , ( 4 ) 431 - 437 .
Gunther U, Holloway JA, Knight A, Chance V, Hanley NA, Wilson DI, French R, Spencer J et al. ( 2005 ) . Erratum: Phenotypic characterization of CD3<sup>-</sup>7<sup>+</sup> cells in developing human intestine and an analysis of their ability to differentiate into T cells (Journal of Immunology (2005) 174 (5414-5422)) . Journal of Immunology vol. 174 , ( 12 )
Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA ( 2005 ) . A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts . Gastroenterology vol. 128 , ( 7 ) 1984 - 1995 .
Gunther U, Holloway JA, Gordon JN, Knight A, Chance V, Hanley NA, Wilson DI, French R et al. ( 2005 ) . Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells . J Immunol vol. 174 , ( 9 ) 5414 - 5422 .
Macdonald TT, Monteleone G ( 2005 ) . Immunity, inflammation, and allergy in the gut . Science vol. 307 , ( 5717 ) 1920 - 1925 .
Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Caruso R, Tersigni R, Alessandroni L et al. ( 2005 ) . Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease . Gastroenterology vol. 128 , ( 3 ) 687 - 694 .
Pender SLF, MacDonald TT ( 2004 ) . Matrix metalloproteinases and the gut - new roles for old enzymes . Curr Opin Pharmacol vol. 4 , ( 6 ) 546 - 550 .
Salmela MT, Pender SLF, Karjalainen-Lindsberg M-L, Puolakkainen P, Macdonald TT, Saarialho-Kere U ( 2004 ) . Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing . Scand J Gastroenterol vol. 39 , ( 11 ) 1095 - 1104 .
Li CKF, Pender SLF, Pickard KM, Chance V, Holloway JA, Huett A, Gonçalves NS, Mudgett JS et al. ( 2004 ) . Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice . J Immunol vol. 173 , ( 8 ) 5171 - 5179 .
Monteleone G, Pallone F, MacDonald TT ( 2004 ) . Smad7 in TGF-beta-mediated negative regulation of gut inflammation . Trends Immunol vol. 25 , ( 10 ) 513 - 517 .
Pender SLF, Croucher PJP, Mascheretti S, Prothero JD, Fisher SA, MacDonald TT, Schreiber S, Ye S ( 2004 ) . Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease . J Med Genet vol. 41 , ( 9 )
Monteleone I, Monteleone G, Del Vecchio Blanco G, Vavassori P, Cucchiara S, MacDonald TT, Pallone F ( 2004 ) . Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa . Gut vol. 53 , ( 8 ) 1090 - 1095 .
Pickard KM, Bremner AR, Gordon JN, MacDonald TT ( 2004 ) . Immune responses . BEST PRACT RES CL GA vol. 18 , ( 2 ) 271 - 285 .
Pickard KM, Bremner AR, Gordon JN, MacDonald TT ( 2004 ) . Microbial-gut interactions in health and disease. Immune responses . Best Pract Res Clin Gastroenterol vol. 18 , ( 2 ) 271 - 285 .
Monteleone G, Del Vecchio Blanco G, Palmieri G, Vavassori P, Monteleone I, Colantoni A, Battista S, Spagnoli LG et al. ( 2004 ) . Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection . Gastroenterology vol. 126 , ( 3 ) 674 - 682 .
Mimura T, Bateman AC, Lee RL, Johnson PA, MacDonald TT, Pender SLF, McDonald PJ, Talbot IC et al. ( 2004 ) . Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease - Reply . DIS COLON RECTUM vol. 47 , ( 3 ) 379 - 379 .
Mimura T, Bateman AC, Lee RL, Johnson PA, McDonald PJ, Talbot IC, Kamm MA, MacDonald TT et al. ( 2004 ) . Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease . Dis Colon Rectum . vol. 47 , 371 - 378 .
Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R et al. ( 2004 ) . A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation . J Biol Chem vol. 279 , ( 6 ) 3925 - 3932 .
MacDonald TT, Monteleone G ( 2004 ) . The Smad signalling pathway in Crohn's disease and ulcerative colitis . MECHANISMS OF INTESTINAL INFLAMMATION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION IN IBD . Editors: Duchmann, R, Blumberg, RS, Neurath, MF, Scholmerich, J et al. , vol. 133 , 133 - 136 .
Macdonald TT ( 2003 ) . A mouse model of intestinal fibrosis? . Gastroenterology vol. 125 , ( 6 ) 1889 - 1892 .
Gordon JN, MacDonald TT ( 2003 ) . Biological therapy in Crohn's disease . Hosp Med vol. 64 , ( 12 ) 708 - 712 .
Simmons CP, Clare S, Ghaem-Maghami M, Uren TK, Rankin J, Huett A, Goldin R, Lewis DJ et al. ( 2003 ) . Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium . Infect Immun vol. 71 , ( 9 ) 5077 - 5086 .
Salvati VM, MacDonald TT, del Vecchio Blanco G, Mazzarella G, Monteleone I, Vavassori P, Auricchio S, Pallone F et al. ( 2003 ) . Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease . Pediatr Res vol. 54 , ( 3 ) 312 - 318 .
Pender SLF, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D, Macdonald TT ( 2003 ) . Matrix metalloproteinases in necrotising enterocolitis . Pediatr Res vol. 54 , ( 2 ) 160 - 164 .
Mazzarella G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Auricchio S et al. ( 2003 ) . Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions . Am J Pathol vol. 162 , ( 6 ) 1845 - 1855 .
Veitch AM, Higgins LM, Bajaj-Elliot M, Farthing MJG, MacDonald TT ( 2003 ) . Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor . Int J Exp Pathol vol. 84 , ( 3 ) 107 - 113 .
Gonçalves NS, Hale C, Dougan G, Frankel G, MacDonald TT ( 2003 ) . Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences . Infect Immun vol. 71 , ( 5 ) 2960 - 2965 .
Hauer AC, Riederer M, Griessl A, Rosegger H, MacDonald TT ( 2003 ) . Cytokine production by cord blood mononuclear cells stimulated with cows milk proteins in vitro: interleukin-4 and transforming growth factor beta-secreting cells detected in the CD45RO T cell population in children of atopic mothers . Clin Exp Allergy vol. 33 , ( 5 ) 615 - 623 .
MacDonald TT ( 2003 ) . The mucosal immune system . Parasite Immunol vol. 25 , ( 5 ) 235 - 246 .
MacDonald TT, Frankel G, Dougan G, Goncalves NS, Simmons C ( 2003 ) . Host defences to Citrobacter rodentium . Int J Med Microbiol vol. 293 , ( 1 ) 87 - 93 .
CROFT NM, Pender SL, Salvati M, Monteleone G, Holloway J, Fairclough PD, MacDonald TT ( 2003 ) . Activated STAT4 and a functional role for IL-12 in human Peyer's patches . J. Immunol. vol. 170 , ( 1 ) 300 - 307 .
MacDonald TT, Mazzarella G, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al. ( 2003 ) . Signal transducer and activator of transcription 1 (STAT1) and suppressor of cytokine signalling 1 (SOCS1) in coeliac disease . Coeliac Disease . Editors: CerfBensussan, N, Brousse, N, CaillatZucman, S, Cellier, C et al. , 89 - 96 .
Salmela MT, MacDonald TT, Black D, Irvine B, Zhuma T, Saarialho-Kere U, Pender SLF ( 2002 ) . Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation . Gut vol. 51 , ( 4 ) 540 - 547 .
MacDonald TT ( 2002 ) . Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers . Gut vol. 51 , ( 3 ) 311 - 312 .
MacDonald TT ( 2002 ) . The biochemical basis of immune enteropathy . J Pediatr Gastroenterol Nutr . vol. 34 Suppl 1 , S27 - S30 .
Monteleone G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P, Troncone R et al. ( 2002 ) . Activation of signal transducer and activator of transcription 1 in celiac disease . GASTROENTEROLOGY vol. 122 , ( 4 ) A386 - A386 .
Li CKF, Goncalves NS, Bachler M, Chance V, Mudgett J, Dougan G, Frankel G, Pender SLF et al. ( 2002 ) . Critical role of stromelysin-1 (MMP-3) in mucosal T cell responses during Citrobacter rodentium infection in mice . GASTROENTEROLOGY vol. 122 , ( 4 ) A272 - A272 .
Chance V, Goncalves NS, Li CKF, Frankel G, Dougan G, Pender SLF, MacDonald TT ( 2002 ) . Matrix metalloproteinases in Citrobacter rodentium infected TNF receptor (p55) knockout mice . GASTROENTEROLOGY vol. 122 , ( 4 ) A273 - A273 .
Simmons CP, Goncalves NS, Ghaem-Maghami M, Bajaj-Elliott M, Clare S, Neves B, Frankel G, Dougan G et al. ( 2002 ) . Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma . J Immunol vol. 168 , ( 4 ) 1804 - 1812 .
Salvati VM, MacDonald TT, Bajaj-Elliott M, Borrelli M, Staiano A, Auricchio S, Troncone R, Monteleone G ( 2002 ) . Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease . Gut vol. 50 , ( 2 ) 186 - 190 .
Gonçalves NS, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, Lewis DJ, Simmons CP, MacDonald TT ( 2001 ) . Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis . Infect Immun vol. 69 , ( 11 ) 6651 - 6659 .
Shaida A, Kenyon G, Devalia J, Davies RJ, MacDonald TT, Pender SL ( 2001 ) . Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis . J Allergy Clin Immunol vol. 108 , ( 5 ) 791 - 796 .
Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT ( 2001 ) . Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease . J Clin Invest vol. 108 , ( 4 ) 601 - 609 .
Jones CA, Vance GH, Power LL, Pender SL, Macdonald TT, Warner JO ( 2001 ) . Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming . J Allergy Clin Immunol vol. 108 , ( 2 ) 235 - 241 .
Monteleone G, Pender SL, Wathen NC, MacDonald TT ( 2001 ) . Interferon-alpha drives T cell-mediated immunopathology in the intestine . Eur J Immunol vol. 31 , ( 8 ) 2247 - 2255 .
Salvati VM, Bajaj-Elliott M, Poulsom R, Mazzarella G, Lundin KE, Nilsen EM, Troncone R, MacDonald TT ( 2001 ) . Keratinocyte growth factor and coeliac disease . Gut vol. 49 , ( 2 ) 176 - 181 .
MacDonald TT, Monteleone G ( 2001 ) . IL-12 and Th1 immune responses in human Peyer's patches . Trends Immunol vol. 22 , ( 5 ) 244 - 247 .
Veitch AM, Kelly P, Zulu I, MacDonald TT, Farthing MJ ( 2001 ) . Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy . Dig Dis Sci vol. 46 , ( 5 ) 1133 - 1138 .
Salmela MT, Pender SLF, Reunala T, MacDonald T, Saarialho-Kere U ( 2001 ) . Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis . GUT vol. 48 , ( 4 ) 496 - 502 .
Monteleone G, Pender SLF, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT ( 2001 ) . Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease (vol 48, pg 425, 2001) . GUT vol. 48 , ( 4 ) 584 - 584 .
Goncalves N, Simmons CP, Ghaem-Maghami M, Monteleone G, Frankel G, Dougan G, MacDonald TT ( 2001 ) . Increased susceptibility of TNFRp55 deficient mice to Citrobacter rodentium (mouse EPEC) infection . GUT vol. 48 , A75 - A75 .
Monteleone G, Pender SL, Alstead E, Hauer AC, Lionetti P, McKenzie C, MacDonald TT ( 2001 ) . Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease . Gut vol. 48 , ( 3 ) 425 - 429 .
Kumberova A, CROFT NM, MacDonald TT, Steer HW, Monteleone G, McKenzie C ( 2001 ) . Blocking Smad7 restores TGF-beta1 signalling in chronic inflammatory bowel disease . J. Clin. Invest. vol. 108 , ( 4 ) 601 - 609 .
MacDonald TT, Nagata S, Fairclough PD, McKenzie C ( 2001 ) . Mucosal immunity - A key to tolerance . NEW CONCEPTS IN PATHOLOGY AND TREATMENT OF AUTOIMMUNE DISORDERS . Editors: Pozzilli, C, Pozzilli, P, Kapp, JF , 89 - 99 .
MacDonald T ( 2001 ) . Seminars in immunology: Introduction . Seminars in Immunology vol. 13 , ( 3 ) 159 - 161 .
MacDonald TT ( 2001 ) . Targets for inflammatory bowel disease - biological therapy . IBD AND SALICYLATES - 5 . Editors: Modigliani, R , vol. 24 , 61 - 65 .
Macdonald TT ( 2001 ) . The worm turns on Helicobacter pylori . Gut vol. 48 , ( 1 ) 10 - 11 .
Nagata S, McKenzie C, Pender SLF, Bajaj-Elliott M, Fairclough PD, Walker-Smith JA, Monteleone G, MacDonald TT ( 2000 ) . Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile . Journal of Immunology vol. 165 , ( 9 ) 5315 - 5321 .
Hartland EL, Huter V, Higgins LM, Goncalves NS, Dougan G, Phillips AD, Macdonald TT, Frankel G ( 2000 ) . Expression of intimin γ from enterohemorrhagic Escherichia coli in Citrobacter rodentium . Infection and Immunity vol. 68 , ( 8 ) 4637 - 4646 .
Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JAW, Pender SLF ( 2000 ) . Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease . Gut vol. 47 , ( 1 )
Fell JME, Paintin M, Arnaud-Battandieri F, Beattie RM, Hollis A, Kitching P, Donnet-Hughes A, MacDonald TT et al. ( 2000 ) . Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease . Alimentary Pharmacology and Therapeutics vol. 14 , ( 3 ) 281 - 289 .
Macdonald TT, Monteleone G, Pender SLF ( 2000 ) . Recent developments in the immunology of inflammatory bowel disease . Scandinavian Journal of Immunology vol. 51 , ( 1 ) 2 - 9 .
Pender SLF, Quinn JJ, Sanderson IR, MacDonald TT ( 2000 ) . Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells . American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 279 , ( 5 42-5 )
Egger B, Bajaj-Elliott M, Macdonald TT, Inglin R, Eysselein VE, Büchler MW ( 2000 ) . Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency . Digestion vol. 62 , ( 4 ) 240 - 248 .
Pender SLF, Salmela MT, Monteleone G, Schnapp D, McKenzie C, Spencer J, Fong S, Saarialho-Kere U et al. ( 2000 ) . Ligation of α4β1 integrin on human intestinal mucosal mesenchymal cells selectively up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype . American Journal of Pathology vol. 157 , ( 6 ) 1955 - 1962 .
Monteleone G, MacDonald TT ( 2000 ) . Manipulation of cytokines in the management of patients with inflammatory bowel disease . Annals of Medicine vol. 32 , ( 8 ) 552 - 560 .
Higgins LM, Frankel G, Connerton I, Gonçalves NS, Dougan G, MacDonald TT ( 1999 ) . Role of bacterial intimin in colonic hyperplasia and inflammation . Science vol. 285 , ( 5427 ) 588 - 591 .
Higgins LM, Frankel G, Douce G, Dougan G, MacDonald TT ( 1999 ) . Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease . Infection and Immunity vol. 67 , ( 6 ) 3031 - 3039 .
MacDonald TT ( 1999 ) . Effector and regulatory lymphoid cells and cytokines in mucosal sites . Current Topics in Microbiology and Immunology vol. 236 , 114 - 135 .
Monteleone G, MacDonald TT, Wathen NC, Pallone F, Pender SLF ( 1999 ) . Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury . Gastroenterology vol. 117 , ( 5 ) 1069 - 1077 .
Souza HS, Elia CCS, Spencer J, MacDonald TT ( 1999 ) . Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease . Gut vol. 45 , ( 6 ) 856 - 863 .
Pender SLF, McKenzie C, Shaida A, MacDonald TT ( 1999 ) . Regulation of matrix metalloproteinases in human intestinal mucosa . Annals of the New York Academy of Sciences . vol. 878 , 581 - 582 .
Fell JME, Paintin M, Donnet-Hughes A, Arnaud-Battandier F, MacDonald TT, Walker-Smith JA ( 1999 ) . Remission induced by a new specific oral polymeric diet in children with Crohn's disease . INFLAMMATORY BOWEL DISEASES . Editors: Bistrian, BR, WalkerSmith, JA , vol. 2 , 187 - 198 .
MacDonald TT, Bajaj-Elliott M, Pender SLF ( 1999 ) . T cells orchestrate intestinal mucosal shape and integrity . Immunology Today vol. 20 , ( 11 ) 505 - 510 .
Howie D, Spencer J, DeLord D, Pitzalis C, Wathen NC, Dogan A, Akbar A, MacDonald TT ( 1998 ) . Extrathymic T cell differentiation in the human intestine early in life . Journal of Immunology vol. 161 , ( 11 ) 5862 - 5872 .
Bajaj-Elliott M, Poulsom R, Pender SLF, Wathen NC, MacDonald TT ( 1998 ) . Interactions between stromal cell-derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia . Journal of Clinical Investigation vol. 102 , ( 8 ) 1473 - 1480 .
Lawrence CE, Paterson JCM, Higgins LM, MacDonald TT, Kennedy MW, Garside P ( 1998 ) . IL-4-regulated enteropathy in an intestinal nematode infection . European Journal of Immunology vol. 28 , ( 9 ) 2672 - 2684 .
MacDonald TT, Riecken EO ( 1998 ) . Session summary . Pathobiology . vol. 66 ,
Pender SLF, Fell JME, Chamow SM, Ashkenazi A, MacDonald TT ( 1998 ) . A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production . Journal of Immunology vol. 160 , ( 8 ) 4098 - 4103 .
Elliott M, Pender S, Poulsom R, MacDonald T ( 1998 ) . Keratinocyte growth factor (FGF-7) and its role in mediating the crypt hyperplasia seen during T cell hypersensitivity in the gut . Gastroenterology vol. 114 ,
Beattie RM, Bentsen BS, Macdonald TT ( 1998 ) . Childhood Crohn's disease and the efficacy of enteral diets . Nutrition vol. 14 , ( 4 ) 345 - 350 .
Macdonald TT ( 1998 ) . Depletion of the enteric nervous system by gene targeting results in haemorrhagic necrosis of the ileum . Gut vol. 43 , ( 6 ) 742 - 743 .
Stallmach A, Strober W, MacDonald TT, Lochs H, Zeitz M ( 1998 ) . Induction and modulation of gastrointestinal inflammation . Immunology Today vol. 19 , ( 10 ) 438 - 441 .
MacDonald TT, Pender SLF ( 1998 ) . Lamina propria T cells . Chemical Immunology vol. 71 , 103 - 117 .
MacDonald TT ( 1998 ) . Preface . Chemical Immunology vol. 71 ,
MacDonald TT, Pender SLF ( 1998 ) . Proteolytic enzymes in inflammatory bowel disease . Inflammatory Bowel Diseases vol. 4 , ( 2 ) 157 - 164 .
Pender SLF, Macdonald TT ( 1998 ) . Regulation of matrix metalloproteinase production in human fetal intestinal mesenchymal cells by cytokines and the bacterial superantigen staphylococcus aureus enterotoxin B . Annals of the New York Academy of Sciences . vol. 859 , 188 - 191 .
Pender SLF, Breese EJ, Gunther U, Howie D, Wathen NC, Schuppan D, MacDonald TT ( 1998 ) . Suppression of T cell-mediated injury in human gut by interleukin 10: Role of matrix metalloproteinases . Gastroenterology vol. 115 , ( 3 ) 573 - 583 .
MacDonald TT ( 1998 ) . T cell immunity to oral allergens . Current Opinion in Immunology vol. 10 , ( 6 ) 620 - 627 .
Bajaj-Elliott M, Pender SLF, Poulsom R, Macdonald TT ( 1998 ) . Upregulation of keratinocyte growth factor during T-Cell immunity in the gut mucosa . Annals of the New York Academy of Sciences . vol. 859 , 184 - 187 .
Macdonald TT ( 1998 ) . Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease . Gut vol. 42 , ( 4 ) 460 - 461 .
Bajaj-Elliott M, Breese E, Poulsom R, Fairclough PD, MacDonald TT ( 1997 ) . Keratinocyte growth factor in inflammatory bowel disease: Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts . American Journal of Pathology vol. 151 , ( 5 ) 1469 - 1476 .
Pender SLF, Tickle SP, Docherty AJP, Howie D, Wathen NC, MacDonald TT ( 1997 ) . A Major Role for Matrix Metalloproteinases in T Cell Injury in the Gut . Journal of Immunology vol. 158 , ( 4 ) 1582 - 1590 .
Hauer AC, Finn TM, MacDonald TT, Spencer J, Isaacson PG ( 1997 ) . Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori . Journal of Clinical Pathology vol. 50 , ( 11 ) 957 - 959 .
MacDonald TT ( 1997 ) . Cytokine gene deleted mice in the study of gastrointestinal inflammation . European Journal of Gastroenterology and Hepatology vol. 9 , ( 11 ) 1051 - 1055 .
Trajman A, MacDonald TT, Elia CCS ( 1997 ) . Intestinal immune cells in Strongyloides stercoralis infection . Journal of Clinical Pathology vol. 50 , ( 12 ) 991 - 995 .
MacDonald TT ( 1997 ) . Oxpentifylline, tumour necrosis factor-α and Crohn's disease . Gut vol. 40 , ( 4 )
Braegger CP, Spencer J, MacDonald TT ( 1996 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 26 , ( 3 ) 1 - 4 .
Braegger CP, MacDonald TT ( 1996 ) . The immunologic basis for celiac disease and related disorders . Seminars in Gastrointestinal Disease vol. 7 , ( 3 ) 124 - 133 .
Braegger CP, Spencer J, MacDonald TT ( 1996 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 26 , ( 2 ) 1 - 4 .
Dogan A, Dunn-Walters DK, MacDonald TT, Spencer J ( 1996 ) . Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections . European Journal of Immunology vol. 26 , ( 6 ) 1240 - 1245 .
MacDonald TT ( 1996 ) . Accessory cells in the human gastrointestinal tract . Histopathology vol. 29 , ( 1 ) 89 - 92 .
Murch SH, Costeloe K, Klein NJ, MacDonald TT ( 1996 ) . Early production of macrophage inflammatory protein-1α occurs in respiratory distress syndrome and is associated with poor outcome . Pediatric Research vol. 40 , ( 3 ) 490 - 497 .
Breese EJ, Bajaj-Elliott M, MacDonald TT ( 1996 ) . Expression of matrix metalloproteinase mrna by smooth muscle cells isolated from the mucosa of children with inflammatory bowel disease . Journal of Pediatric Gastroenterology and Nutrition vol. 22 , ( 4 )
Penney L, Kilshaw PJ, Macdonald TT ( 1996 ) . Increased division of αβ TCR<sup>+</sup> and γδ TCR<sup>+</sup> intestinal intraepithelial lymphocytes after oral administration of cholera toxin . Immunology vol. 89 , ( 1 ) 54 - 58 .
Murch SH, Costeloe K, Klein NJ, Rees H, McIntosh N, Keeling JW, MacDonald TT ( 1996 ) . Mucosal tumor necrosis factor-α production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome . Pediatric Research vol. 40 , ( 3 ) 484 - 489 .
Pender SLF, Lionetti P, Murch SH, Wathan N, MacDonald TT ( 1996 ) . Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation . Gut vol. 39 , ( 2 ) 284 - 290 .
Thomas R, Schürmann G, Lionetti P, Pender SLF, MacDonald TT ( 1996 ) . T cell receptor Vβ expression in human intestine: Regional variation in postnatal intestine and biased usage in fetal gut . Gut vol. 38 , ( 2 ) 190 - 195 .
Fell JME, Walker-Smith JA, Spencer J, Macdonald TT ( 1996 ) . The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD) . Clinical and Experimental Immunology vol. 104 , ( 2 ) 280 - 285 .
Braegger CP, Spencer J, MacDonald TT ( 1995 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical and Laboratory Research vol. 25 , ( 4 ) 1 - 4 .
Breese EJ, Michie CA, Nicholls SW, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT ( 1995 ) . The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease . Aliment Pharmacol Ther vol. 9 , ( 5 ) 547 - 552 .
MacDonald TT ( 1995 ) . Evidence for cell-mediated hypersensitivity as an important pathogenetic mechanism in food intolerance . Clinical and Experimental Allergy, Supplement vol. 25 , ( 1 ) 10 - 13 .
Taylor J, MacDonald TT, Spencer J ( 1995 ) . 4D5.4, A monoclonal antibody which recognizes cells in inflamed human intestine . Advances in Experimental Medicine and Biology . vol. 371 , 1331 - 1332 .
MacDonald TT ( 1995 ) . Breakdown of tolerance to the intestinal bacterial flora in inflammatory bowel disease (IBD) . Clinical and Experimental Immunology vol. 102 , ( 3 ) 445 - 447 .
Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT ( 1995 ) . Distribution and density of TNF immunoreactivity in chronic inflammatory bowel disease . Advances in Experimental Medicine and Biology . vol. 371 , 1327 - 1330 .
Dogan A, MacDonald TT, Spencer J ( 1995 ) . Expression of cell adhesion molecules in the fetal gut . Advances in Experimental Medicine and Biology . vol. 371 , 141 - 143 .
Karttunen R, Karttunen T, Ekre HPT, MacDonald TT ( 1995 ) . Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis . Gut vol. 36 , ( 3 ) 341 - 345 .
Lionetti P, Murch SH, Taylor J, MacDonald TT ( 1995 ) . Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine . Advances in Experimental Medicine and Biology vol. 371 , ( A ) 493 - 496 .
Penney L, Kilshaw PJ, MacDonald TT ( 1995 ) . Regional variation in the proliferative rate and lifespan of αβ TCR<sup>+</sup> and γδ TCR<sup>+</sup> intraepithelial lymphocytes in the murine small intestine . Immunology vol. 86 , ( 2 ) 212 - 218 .
Breese E, MacDonald TT ( 1995 ) . TNFα secreting cells in normal and diseases human intestine . Advances in Experimental Medicine and Biology . vol. 371 , 821 - 824 .
Beattie RM, Schiffrin EJ, Donnet-Hughes A, Huggett AC, Domizio P, MacDonald TT, Walker-Smith JA ( 1994 ) . Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease . Aliment Pharmacol Ther vol. 8 , ( 6 ) 609 - 615 .
Breese EJ, Kumar P, Farthing MJ, MacDonald TT ( 1994 ) . Interleukin-2 and interferon-γ producing cells in the lamina propria in celiac disease . Digestive Diseases and Sciences vol. 39 , ( 10 )
Macdonald TT ( 1994 ) . Gastrointestinal Inflammation: Inflammatory bowel disease in knockout mice . Current Biology vol. 4 , ( 3 ) 261 - 263 .
Macdonald TT ( 1994 ) . Oral Tolerance: Eating your way towards immunosuppression . Current Biology vol. 4 , ( 2 ) 178 - 181 .
MacDonald TT, Spencer J, Murch SH, Choy MY, Venugopal S, Bundy DAP, Cooper ES ( 1994 ) . 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery . Transactions of the Royal Society of Tropical Medicine and Hygiene vol. 88 , ( 3 ) 265 - 268 .
Macdonald TT, Murch SH ( 1994 ) . Aetiology and pathogenesis of chronic inflammatory bowel disease . Bailliere's Clinical Gastroenterology vol. 8 , ( 1 ) 1 - 34 .
Nicholls S, Domizio P, Williams CB, Dawnay A, Braegger CP, MacDonald TT, Walker-Smith JA ( 1994 ) . Cyclosporin as initial treatment for Crohn's disease . Archives of Disease in Childhood vol. 71 , ( 3 ) 243 - 247 .
Karttunnen R, Breese EJ, Walker-Smith JA, MacDonald TT ( 1994 ) . Decreased mucosal interleukin-4 (IL-4) production in gut inflammation . Journal of Clinical Pathology vol. 47 , ( 11 ) 1015 - 1018 .
Walker-Smith JA, MacDonald TT ( 1994 ) . Foreward . Bailliere's Clinical Gastroenterology vol. 8 , ( 1 )
Walker-Smith JA, Macdonald TT ( 1994 ) . Foreword . Bailliere's Clinical Gastroenterology vol. 8 , ( 1 )
Batman PA, Fleming SC, Sedgwick PM, MacDonald TT, Griffin GE ( 1994 ) . HIV infection of human fetal intestinal explant cultures induces epithelial cell proliferation . AIDS vol. 8 , ( 2 ) 161 - 167 .
Latthe M, Terry L, Macdonald TT ( 1994 ) . High frequency of CD8αα homodimer‐bearing T cells in human fetal intestine . European Journal of Immunology vol. 24 , ( 7 ) 1703 - 1705 .
Braegger CP, MacDonald TT ( 1994 ) . Immune mechanisms in chronic inflammatory bowel disease . Annals of Allergy vol. 72 , ( 2 ) 135 - 141 .
MacDonald TT ( 1994 ) . Inflammatory bowel disease in children . Current Opinion in Pediatrics vol. 6 , ( 5 ) 547 - 555 .
Murch S, MacDonald T, Costeloe K ( 1994 ) . Macrophage-associated chemokines and cytokines in neonatal respiratory distress syndrome . Early Human Development . vol. 38 ,
MacDonald TT, Spencer J ( 1994 ) . Ontogeny of the gut‐associated lymphoid system in man . Acta Pædiatrica vol. 83 , 3 - 5 .
Murch SH, MacDonald TT, Walker-Smith JA, Lionetti P, Levin M, Klein NJ ( 1993 ) . Disruption of sulphated glycosaminoglycans in intestinal inflammation . The Lancet vol. 341 , ( 8847 ) 711 - 714 .
Lionetti P, Spencer J, Breese EJ, Murch SH, Taylor J, Macdonald TT ( 1993 ) . Activation of mucosal Vβ3<sup>+</sup> T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B . European Journal of Immunology vol. 23 , ( 3 ) 664 - 668 .
MacDonald TT ( 1993 ) . Aetiology of Crohn's disease . Archives of Disease in Childhood vol. 68 , ( 5 ) 623 - 625 .
Doǧan A, MacDonald TT, Spencer J ( 1993 ) . Cyclosporin A enhances T cell‐mediated induction of E‐selectin . European Journal of Immunology vol. 23 , ( 11 ) 2922 - 2926 .
Nicholls S, Stephens S, Braegger CP, Walker-Smith JA, MacDonald TT ( 1993 ) . Cytokines in stools of children with inflammatory bowel disease or infective diarrhea . Journal of Clinical Pathology vol. 46 , ( 8 ) 757 - 760 .
MacDonald TT, Spencer J ( 1993 ) . Development of gastrointestinal immune function and its relationship to intestinal disease . Current Opinion in Gastroenterology vol. 9 , ( 6 ) 946 - 952 .
Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT ( 1993 ) . Interleukin-2- and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa . Immunology vol. 78 , ( 1 ) 127 - 131 .
Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT ( 1993 ) . Location of tumour necrosis factor a by immunohistochemistry in chronic inflammatory bowel disease . Gut vol. 34 , ( 12 ) 1705 - 1709 .
Dogan A, MacDonald TT, Spencer J ( 1993 ) . Ontogeny and induction of adhesion molecule expression in human fetal intestine . Clinical and Experimental Immunology vol. 91 , ( 3 ) 532 - 537 .
MacDonald TT ( 1993 ) . T cell-mediated immunity and tissue damage in the gut . Canadian Journal of Gastroenterology . vol. 7 , 87 - 90 .
Lionetti P, Breese E, Braegger CP, Murch SH, Taylor J, MacDonald TT ( 1993 ) . T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine . Gastroenterology vol. 105 , ( 2 ) 373 - 381 .
Braegger CP, Torresani T, Murch SH, Savage MO, Walker-Smith JA, MacDonald TT ( 1993 ) . Urinary growth hormone in growth-impaired children with chronic inflammatory bowel disease . Journal of Pediatric Gastroenterology and Nutrition vol. 16 , ( 1 ) 49 - 52 .
Braegger CP, Spencer J, MacDonald TT ( 1992 ) . Ontogenetic aspects of the intestinal immune system in man . International Journal of Clinical &amp; Laboratory Research vol. 22 , ( 1-4 ) 1 - 4 .
Murch SH, Braegger CP, MacDonald TT, Sessa WC ( 1992 ) . High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis . The Lancet vol. 339 , ( 8790 ) 381 - 385 .
Braegger CP, Nicholls S, Murch SH, MacDonald TT, Stephens S ( 1992 ) . Tumour necrosis factor alpha in stool as a marker of intestinal inflammation . The Lancet vol. 339 , ( 8785 ) 89 - 91 .
Evans CM, Phillips AD, Walker-Smith JA, MacDonald TT ( 1992 ) . Activation of lamina propria T cells induces crypt epithelial proliferation and goblet cell depletion in cultured human fetal colon . Gut vol. 33 , ( 2 ) 230 - 235 .
MacDonald TT ( 1992 ) . Celiac disease (gluten-sensitive enteropathy) . Clinical Immunology Newsletter vol. 12 , ( 10-11 ) 156 - 161 .
MacDonald TT, Spencer J ( 1992 ) . Cell-mediated immune injury in the intestine . Gastroenterology Clinics of North America vol. 21 , ( 2 ) 367 - 386 .
Savilahti E, Heyman M, MacDonald T, Navarro J, Stern M, Strobel S, Vandenplas Y, Walker-Smith JA ( 1992 ) . Diagnostic criteria for food allergy with predominantly intestinal symptoms . Journal of Pediatric Gastroenterology and Nutrition vol. 14 , ( 1 ) 108 - 112 .
Fleming SC, Kapembwa MS, MacDonald TT, Griffin GE ( 1992 ) . Direct in vitro infection of human intestine with HIV-1 . AIDS vol. 6 , ( 10 ) 1099 - 1104 .
Cooper ES, Whyte-Alleng CAM, Finzi-Smith JS, Macdonald TT ( 1992 ) . Intestinal nematode infections in children the pathophysiological price paid . Parasitology vol. 104 , ( S1 ) S91 - S103 .
Viney JL, MacDonald TT ( 1992 ) . Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine . Immunology vol. 77 , ( 1 ) 19 - 24 .
MacDonald TT ( 1992 ) . The mucosal immune system in human immunodeficiency virus infection . European Journal of Gastroenterology and Hepatology vol. 4 , ( 6 ) 390 - 395 .
Murch SH, MacDonald TT, Wood CBS, Costeloe KL ( 1992 ) . Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment . Thorax vol. 47 , ( 1 ) 44 - 47 .
Cooper ES, Bundy DAP, Whyte-Alleng CAM, Venugopal S, Spencer J, Whitney P, Cromwell O, Haynes B et al. ( 1991 ) . Immediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery . The Lancet vol. 338 , ( 8775 ) 1104 - 1107 .
MacDonald TT, Choy MY, Spencer J, Richman PI, Diss T, Hanchard B, Venugopal S, Bundy DAP et al. ( 1991 ) . Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome . Journal of Clinical Pathology vol. 44 , ( 3 ) 194 - 199 .
Mahida YR, MacDonald TT ( 1991 ) . Interleukin-2 receptor expression [2] . Gut vol. 32 , ( 4 ) 456 - 457 .
Murch SH, Lamkin VA, Savage MO, Walker-Smith JA, MacDonald TT ( 1991 ) . Serum concentrations of tumour necrosis factor in childhood chronic inflammatory bowel disease . Gut vol. 32 , ( 8 ) 913 - 917 .
Spencer J, Choy MY, MacDonald TT ( 1991 ) . T cell receptor Vβ expression by mucosal T cells . Journal of Clinical Pathology vol. 44 , ( 11 ) 915 - 918 .
Murch S, Macdonald T, Goldin RD, Hunt NCA, Riches PG, Gooding R ( 1990 ) . In-vitro production of cytokines in serum . The Lancet vol. 336 , ( 8716 ) 687 - 688 .
Cooper ES, Bundy DAP, MacDonald TT, Golden MHN ( 1990 ) . Growth suppression in the Trichuris dysentery syndrome . European Journal of Clinical Nutrition vol. 44 , ( 4 ) 285 - 291 .
Ferreira RDC, Forsyth LE, Richman PI, Wells C, Spencer J, MacDonald TT ( 1990 ) . Changes in the rate of crypt epithelial cell proliferation and mucosal morphology induced by a T-cell-mediated response in human small intestine . Gastroenterology vol. 98 , ( 5 PART 1 ) 1255 - 1263 .
Viney JL, Kilshaw PJ, MacDonald TT ( 1990 ) . Cytotoxic α/β<sup>+</sup> and γ/δ<sup>+</sup> T cells in murine intestinal epithelium . European Journal of Immunology vol. 20 , ( 7 ) 1623 - 1626 .
Choy MY, Walker-Smith JA, Williams CB, MacDonald TT ( 1990 ) . Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis . Gut vol. 31 , ( 12 ) 1365 - 1370 .
Choy M, Richman PI, Horton MA, Macdonald TT ( 1990 ) . Expression of the VLA family of integrins in human intestine . The Journal of Pathology vol. 160 , ( 1 ) 35 - 40 .
Viney J, MacDonald TT, Spencer J ( 1990 ) . Gamma/delta T cells in the gut epithelium . Gut vol. 31 , ( 8 ) 841 - 844 .
Macdonald TT, Spencer J ( 1990 ) . Gut immunology . Bailliere's Clinical Gastroenterology vol. 4 , ( 2 ) 291 - 313 .
MacDonald TT, Horton MA, Choy MY, Richman PI ( 1990 ) . Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine . Journal of Clinical Pathology vol. 43 , ( 4 ) 313 - 315 .
MacDonald TT, Spencer J ( 1990 ) . Ontogeny of the mucosal immune response . Springer Seminars in Immunopathology vol. 12 , ( 2-3 ) 129 - 137 .
Viney JL, Macdonald TT ( 1990 ) . Selective death of T cell receptor γ/δ<sup>+</sup> intraepithelial lymphocytes by apoptosis . European Journal of Immunology vol. 20 , ( 12 ) 2809 - 2812 .
MacDonald TT, Spencer J ( 1990 ) . The role of activated T cells in transformed intestinal mucosa . Digestion vol. 46 , 290 - 296 .
MACDONALD TT ( 1990 ) . The role of activated T lymphocytes in gastrointestinal disease . Clinical &amp; Experimental Allergy vol. 20 , ( 3 ) 247 - 252 .
Braegger CP, Corrigan CJ, MacDonald TT ( 1990 ) . Toothpaste and Crohn's disease (III) . Lancet vol. 336 , ( 8727 )
MacDonald TT, Hutchings P, Choy MY, Murch S, Cooke A ( 1990 ) . Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine . Clinical and Experimental Immunology vol. 81 , ( 2 ) 301 - 305 .
Spencer JO, Macdonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG ( 1989 ) . Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine) . Gut vol. 30 , ( 3 ) 339 - 346 .
Walker-Smith J, MacDonald T ( 1989 ) . Insights provided by the study of the small intestine in the child and the foetus . Gut vol. 30 , ( SPEC NO ) 11 - 16 .
Viney JL, MacDonald TT, Kilshaw PJ ( 1989 ) . T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice . Immunology vol. 66 , ( 4 ) 583 - 587 .
Viney JL, MacDonald TT, Kilshaw PJ ( 1989 ) . αβ T cell receptor expression in rat intestinal epithelium . Immunology Letters vol. 23 , ( 1 ) 49 - 53 .
MacDonald TT, Spencer J ( 1988 ) . Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine . Journal of Experimental Medicine vol. 167 , ( 4 ) 1341 - 1349 .
MacDonald TT, Weinel A, Spencer J ( 1988 ) . HLA-DR expression in human fetal intestinal epithelium . Gut vol. 29 , ( 10 ) 1342 - 1348 .
Hancock GE, Schaedler RW, MacDonald TT ( 1988 ) . Multigenic control of resistance to Yersinia enterocolitica in inbred strains of mice . Infection and Immunity vol. 56 , ( 2 ) 532 - 533 .
Crane MSJ, Murray PK, Gnozzio MJ, MacDonald TT ( 1988 ) . Passive protection of chickens against Eimeria tenella infection by monoclonal antibody . Infection and Immunity vol. 56 , ( 4 ) 972 - 976 .
Monk T, Spencer J, Cerf-Bensussan N, Macdonald TT ( 1988 ) . Stimulation of mucosal T cells in situ with anti-CD3 antibody: Location of the activated T cells and their distribution within the mucosal micro-environment . Clinical and Experimental Immunology vol. 74 , ( 2 ) 216 - 222 .
Walker-Smith JA, MacDonald TT ( 1987 ) . Intestinal lymphoid cells . Digestive Diseases and Sciences vol. 32 , ( 7 )
Spencer J, MacDonald TT, Isaacson PG ( 1987 ) . Development of human gut-associated lymphoid tissue . Advances in experimental medicine and biology vol. 216 B , 1421 - 1430 .
Spencer J, Macdonald TT, Isaacson PG ( 1987 ) . Heterogeneity of non-lymphoid cells expressing HLA-D region antigens in human fetal gut . Clinical and Experimental Immunology vol. 67 , ( 2 ) 415 - 424 .
MacDonald TT, Spencer J, Viney JL, Williams CB, Walker-Smith JA ( 1987 ) . Selective biopsy of human Peyer's patches during ileal endoscopy . Gastroenterology vol. 93 , ( 6 ) 1356 - 1362 .
Zemcik BA, Murray PK, MacDonald TT ( 1986 ) . Detection of chicken antibody to the protozoan parasite Eimeria tenella by antigen-coated microspheres . Journal of Immunological Methods vol. 91 , ( 2 ) 265 - 269 .
Macdonald TT, Spencer J, Viney J, Williams C, Walker-Smith JA ( 1986 ) . FUNCTIONAL STUDIES ON CELLS FROM HUMAN PEYER'S PATCHES. THEIR PHENOTYPE AND IN VITRO PROLIFERATIVE RESPONSES . Pediatric Research vol. 20 , ( 7 ) 689 - 689 .
Dillon SB, MacDonald TT ( 1986 ) . Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes . Immunology vol. 59 , ( 3 ) 389 - 396 .
DILLON SB, MACDONALD TT ( 1986 ) . Limit dilution analysis of mast cell precursor frequency in the gut epithelium of normal and Trichinella spiralis infected mice . Parasite Immunology vol. 8 , ( 5 ) 503 - 511 .
Dillon SB, Dalton BJ, MacDonald TT ( 1986 ) . Lymphokine production by mitogen and antigen activated mouse intraepithelial lymphocytes . Cellular Immunology vol. 103 , ( 2 ) 326 - 338 .
MacDonald TT, Calkins CE, Rothermel AL ( 1986 ) . Modulation in vivo of Lyt 2 antigen expression on T cells by anti-Lyt 2 antibody: Effects on Con A-induced unresponsiveness . Immunology vol. 59 , ( 2 ) 181 - 186 .
Spencer J, Dillon SB, Isaacson PG, MacDonald TT ( 1986 ) . T cell subclasses in fetal human ileum . Clinical and Experimental Immunology vol. 65 , ( 3 ) 553 - 558 .
Spencer J, MacDonald TT, Finn T, Isaacson PG ( 1986 ) . The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine . Clinical and Experimental Immunology vol. 64 , ( 3 ) 536 - 543 .
Hancock GE, Schaedler RW, MacDonald TT ( 1986 ) . Yersinia enterocolitica infection in resistant and susceptible strains of mice . Infection and Immunity vol. 53 , ( 1 ) 26 - 31 .
Anderson AO, MacDonald TT, Rubin DH ( 1985 ) . Effect of orally administered avridine on enteric antigen uptake and mucosal immunity . International Journal of Immunotherapy vol. 1 , ( 2 ) 107 - 115 .
Dillon SB, MacDonald TT ( 1985 ) . Isolation and function of mucosal lymphocytes in the mouse . Progress in clinical and biological research vol. 181 , 381 - 385 .
Dillon SB, MacDonald TT ( 1985 ) . Lymphokine Production by T Lymphocytes Isolated from Murine Small Intestinal Epithelium . Microenvironments in the Lymphoid System ,
Dillon SB, MacDonald TT ( 1985 ) . Lymphokine production by T lymphocytes isolated from murine small intestinal epithelium . Advances in experimental medicine and biology vol. 186 , 701 - 711 .
Dillon SB, MacDonald TT ( 1985 ) . Lymphokine production by mitogen or antigen activated intraepithelial lymphocytes from mouse small intestine . Federation Proceedings vol. 44 , ( 4 )
Hancock GE, MacDonald TT ( 1985 ) . Natural resistance in murine yersiniosis . Federation Proceedings vol. 44 , ( 3 )
Dillon SB, MacDonald TT ( 1984 ) . Functional properties of lymphocytes isolated from murine small intestinal epithelium . Immunology vol. 52 , ( 3 ) 501 - 509 .
Macdonald TT ( 1983 ) . Immunosuppression caused by antigen feeding II. Suppressor T cells mask Peyer's patch B cell priming to orally administered antigen . European Journal of Immunology vol. 13 , ( 2 ) 138 - 142 .
MacDonald TT ( 1982 ) . Cell-interactions in the splenic suppression caused by antigen-feeding . Advances in experimental medicine and biology vol. 149 , 659 - 668 .
MacDonald TT ( 1982 ) . Enhancement and suppression of the Peyer's patch immune response by systemic priming . Clinical and Experimental Immunology vol. 49 , ( 2 ) 441 - 448 .
Macdonald TT ( 1982 ) . Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen‐fed mice . European Journal of Immunology vol. 12 , ( 9 ) 767 - 773 .
MacDonald TT, Carter PB ( 1982 ) . Isolation and functional characteristics of adherent phagocytic cells from mouse Peyer's patches . Immunology vol. 45 , ( 4 ) 769 - 774 .
MacDonald TT, Bashore M, Carter PB ( 1982 ) . Nonspecific resistance to infection expressed within the Peyer's patches of the small intestine . Infection and Immunity vol. 37 , ( 1 ) 390 - 392 .
Macdonald TT, Carter PB ( 1981 ) . A functional relationship between delayed hypersensitivtiy and antibacterial immunity . Immunological Investigations vol. 10 , ( 7 ) 591 - 599 .
MacDonald TT, Carter PB ( 1980 ) . Cell-mediated immunity to intestinal infection . Infection and Immunity vol. 28 , ( 2 ) 516 - 523 .
Murphy JR, Carter PB, MacDonald TT ( 1980 ) . Host defenses in murine malaria: Failure of vaccination with formolized blood parasites to protect athymic mice from Plasmodium berghei . Infection and Immunity vol. 29 , ( 2 ) 827 - 830 .
Ferguson A, Logan RFA, MacDonald TT ( 1980 ) . Increased mucosal damage during parasite infection in mice fed an elemental diet . Gut vol. 21 , ( 1 ) 37 - 43 .
MacDonald TT, Murray M, Ferguson A ( 1980 ) . Nippostrongylus brasiliensis: Mast cell kinetics at small intestinal sites in infected rats . Experimental Parasitology vol. 49 , ( 1 ) 9 - 14 .
Carter PB, MacDonald TT, Collins FM ( 1979 ) . Host responses to infection with Yersinia enterocolitica . Contributions to microbiology and immunology vol. 5 , 346 - 350 .
MacDonald TT, Carter PB ( 1979 ) . Requirement for a bacterial flora before mice generate cells capable of mediating the delayed hypersensitivity reaction to sheep red blood cells . Journal of Immunology vol. 122 , ( 6 ) 2624 - 2629 .
MacDonald TT, Carter PB, Phillips PG ( 1979 ) . Modulation of cellular immunity by the enteric flora: Delayed type hypersensitivity in the gnotobiotic mouse . Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A vol. 245 , ( Suppl. 7 ) 221 - 226 .
MacDonald TT, Carter PB ( 1978 ) . Contact sensitivity in the germ-free mouse . RES Journal of the Reticuloendothelial Society vol. 24 , ( 3 ) 287 - 293 .
Scott MT, MacDonald TT, Carter PB ( 1978 ) . C. parvum in germ-free mice . Cancer Immunology Immunotherapy vol. 4 , ( 2 ) 135 - 137 .
Ferguson A, Carr KE, Macdonald TT, Watt C ( 1978 ) . Hypersensitivity reactions in the small intestine: Iv. influence of allograft rejection on small intestinal mucosal architecture: A scanning and transmission electron microscope study . Digestion vol. 18 , ( 1-2 ) 56 - 63 .
Ferguson A, Paul G, MacDonald TT ( 1978 ) . Immunodeficiency and fatty liver in mice reared on an elemental diet . Arquivos de Gastroenterologia vol. 15 , ( 1 ) 11 - 15 .
MacDonald TT, Carter P ( 1978 ) . Mouse peyer’s patches contain t cells capable of inducing the graft–versus–host reaction (GVHR) . Transplantation vol. 26 , ( 3 ) 162 - 165 .
MacDonald TT, Ferguson A ( 1978 ) . Small intestinal epithelial cell kinetics and protozoal infection in mice . Gastroenterology vol. 74 , ( 3 ) 496 - 500 .
Ferguson A, MacDonald TT ( 1977 ) . Effects of local delayed hypersensitivity on the small intestine . Ciba Foundation symposium ( 46 ) 305 - 327 .
MacDonald TT, Ferguson A ( 1977 ) . HYPERSENSITIVITY REACTIONS IN THE SMALL INTESTINE: III. THE EFFECTS OF ALLOGRAFT REJECTION AND OF GRAFT‐VERSUS‐HOST DISEASE ON EPITHELIAL CELL KINETICS . Cell Proliferation vol. 10 , ( 4 ) 301 - 312 .
Ferguson A, Sutherland A, MacDonald TT, Allan F ( 1977 ) . Technique for microdissection and measurement in biopsies of human small intestine . Journal of Clinical Pathology vol. 30 , ( 11 ) 1068 - 1073 .
MacDonald TT, Ferguson A ( 1976 ) . Hypersensitivity reactions in the samll intestine. II. Effexts of allograft rejection on mucosal architecture and lymphoid cell infiltrate . Gut vol. 17 , ( 2 ) 81 - 91 .
Ferguson A, Mcclure JP, Macdonald TT, Holden RJ ( 1975 ) . CELL-MEDIATED IMMUNITY TO GLIADIN WITHIN THE SMALL-INTESTINAL MUCOSA IN CŒLIAC DISEASE . The Lancet vol. 305 , ( 7912 ) 895 - 897 .
Ferguson A, MacDonald TT ( 1975 ) . Activated T lymphocytes in clinical and experimental small bowel disease . Acta Paediatrica Scandinavica vol. 64 , ( 1 )
Ferguson A, MacDonald TT ( 1975 ) . Effects of local hypersensitivity reactions on small intestinal morphology . BEHRING INST.MITT. vol. No. 57 , 118 - 121 .