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Research

Publications: Dr Tania Maffucci

Branco M, Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, Cleal J et al. ( 2022 ) . Regulation of human trophoblast gene expression by endogenous retroviruses .
Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, Cleal J, Caley M et al. ( 2022 ) . Regulation of human trophoblast gene expression by endogenous retroviruses .
Heng EYZ, Maffucci T ( 2022 ) . An Overview of Class II Phosphoinositide 3-Kinases . vol. 436 , 51 - 68 .
Allan HE, Hayman MA, Marcone S, Chan MV, Edin ML, Maffucci T, Joshi A, Menke L et al. ( 2021 ) . Proteome and functional decline as platelets age in the circulation . Journal of Thrombosis and Haemostasis vol. 19 , ( 12 ) 3095 - 3112 .
Mannella V, Boehm K, Celik S, Ali T, Mirza AN, Hasnaouy ME, Kaffa A, Lyu Y et al. ( 2021 ) . Growth and viability of cutaneous squamous cell carcinoma cell lines display different sensitivities to isoform-specific phosphoinositide 3-kinase inhibitors . International Journal of Molecular Sciences vol. 22 , ( 7 )
Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A et al. ( 2021 ) . A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis . American Journal of Hematology vol. 96 , ( 3 ) E83 - E88 .
Maffucci T, Falasca M ( 2020 ) . Signalling Properties of Inositol Polyphosphates . Molecules vol. 25 , ( 22 )
Maffucci T, Falasca M ( 2020 ) . Inositol polyphosphate-based compounds as inhibitors of phosphoinositide 3-kinase-dependent signaling . International Journal of Molecular Sciences vol. 21 , ( 19 ) 1 - 15 .
Emmanouilidi A, Casari I, Akkaya BG, Maffucci T, Furic L, Guffanti F, Broggini M, Chen X et al. ( 2020 ) . Inhibition of the lysophosphatidylinositol transporter abcc1 reduces prostate cancer cell growth and sensitizes to chemotherapy . Cancers vol. 12 , ( 8 ) 1 - 19 .
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al. ( 2020 ) . Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin . The FASEB Journal
Patel A, Garcia LF, Mannella V, Gammon L, Borg TM, Maffucci T, Scatolini M, Chiorino G et al. ( 2020 ) . Targeting p63 upregulation abrogates resistance to MAPK inhibitors in melanoma . Cancer Research vol. 80 , ( 12 ) 2676 - 2688 .
Cisse O, Quraishi M, Gulluni F, Guffanti F, Mavrommati I, Suthanthirakumaran M, Oh LCR, Schlatter JN et al. ( 2019 ) . Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth . Journal of Experimental and Clinical Cancer Research vol. 38 , ( 1 )
Mannella V, Bergamaschi D, Harwood C, Maffucci T ( 2019 ) . Targeting selective phosphoinositide-3-kinase isoforms as a novel strategy in cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 180 , E213 - E213 .
Emmanouilidi A, Fyffe CA, Ferro R, Edling CE, Capone E, Sestito S, Rapposelli S, Lattanzio R et al. ( 2019 ) . Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer . Journal of Experimental and Clinical Cancer Research vol. 38 , ( 1 )
Ferro R, Adamska A, Lattanzio R, Mavrommati I, Edling CE, Arifin SA, Fyffe CA, Sala G et al. ( 2018 ) . GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine . Oncogene vol. 37 , ( 49 ) 6368 - 6382 .
Arifin SA, Paternoster S, Carlessi R, Casari I, Ekberg JH, Maffucci T, Newsholme P, Rosenkilde MM et al. ( 2018 ) . Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119 . Biochim Biophys Acta vol. 1863 , ( 9 ) 1132 - 1141 .
Crescente M, Armstrong PC, Chan MV, Edin ML, Maffucci T, Kirkby NS, Mitchell JA, Zeldin DC et al. ( 2018 ) . Understanding the cardiovascular effects of low dose aspirin by using a platelet COX-1-/- mouse model . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 ,
Janus JM, O’Shaughnessy RFL, Harwood CA, Maffucci T ( 2017 ) . Phosphoinositide 3-kinase-dependent signalling pathways in cutaneous squamous cell carcinomas . Cancers vol. 9 , ( 7 )
Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M ( 2017 ) . Correction: A novel regulatory mechanism links PLCγ1 to PDK1 [J. Cell Sci. 125, (3153-3163)] . Journal of Cell Science vol. 130 , ( 5 )
Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T et al. ( 2016 ) . A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion . Scientific Reports vol. 6 , 26142 - 26142 .
Mavrommati I, Cisse O, Falasca M, Maffucci T ( 2016 ) . Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion . Scientific Reports vol. 6 ,
Chikh A, Ferro R, Abbott JJ, Piñeiro R, Buus R, Iezzi M, Ricci F, Bergamaschi D et al. ( 2016 ) . Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression . Oncotarget vol. 7 , ( 14 ) 18325 - 18345 .
Maffucci T, Falasca M ( 2014 ) . New insight into the intracellular roles of class II phosphoinositide 3-kinases . Biochem Soc Trans vol. 42 , ( 5 ) 1378 - 1382 .
Falasca M, Casari I, Maffucci T ( 2014 ) . Cancer chemoprevention with nuts . J Natl Cancer Inst vol. 106 , ( 9 )
Edling CE, Selvaggi F, Ghonaim R, Maffucci T, Falasca M ( 2014 ) . Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway . Cancer Biol Ther vol. 15 , ( 5 ) 524 - 532 .
Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D et al. ( 2014 ) . PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function . Dev Cell vol. 28 , ( 6 ) 647 - 658 .
Maffucci T, Falasca M ( 2014 ) . Analysis, regulation, and roles of endosomal phosphoinositides . Methods Enzymol vol. 535 , 75 - 91 .
Mazza S, Maffucci T ( 2014 ) . Autophagy and pancreatic β-cells . Vitam Horm vol. 95 , 145 - 164 .
Falasca M, Maffucci T ( 2014 ) . Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts . Front Physiol vol. 5 ,
Mazza S, Maffucci T, Falasca M ( 2013 ) . Investigating the mechanisms of activation and action of phosphoinositide 3-kinase C2 alpha in pancreatic beta cells . DIABETIC MEDICINE vol. 30 , 32 - 32 .
Tibolla G, Piñeiro R, Chiozzotto D, Mavrommati I, Wheeler AP, Norata GD, Catapano AL, Maffucci T et al. ( 2013 ) . Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis . PLoS One vol. 8 , ( 1 )
Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M ( 2012 ) . A novel regulatory mechanism links PLCγ1 to PDK1 . J Cell Sci vol. 125 , ( Pt 13 ) 3153 - 3163 .
Falasca M, Maffucci T ( 2012 ) . Regulation and cellular functions of class II phosphoinositide 3-kinases . Biochem J vol. 443 , ( 3 ) 587 - 601 .
Maffucci T ( 2012 ) . An introduction to phosphoinositides . Curr Top Microbiol Immunol vol. 362 , 1 - 42 .
Mavrommati I, Maffucci T ( 2011 ) . mTOR Inhibitors: Facing New Challenges Ahead . Curr Med Chem
Dominguez V, Raimondi C, Somanath S, Bugliani M, Loder MK, Edling CE, Divecha N, da Silva-Xavier G et al. ( 2011 ) . Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells . J Biol Chem vol. 286 , ( 6 ) 4216 - 4225 .
Piñeiro R, Maffucci T, Falasca M ( 2011 ) . The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation . Oncogene vol. 30 , ( 2 ) 142 - 152 .
Falasca M, Raimondi C, Maffucci T ( 2011 ) . Boyden chamber . Methods Mol Biol vol. 769 , 87 - 95 .
Mazza S, Maffucci T ( 2011 ) . Class II phosphoinositide 3-kinase C2alpha: what we learned so far . Int J Biochem Mol Biol vol. 2 , ( 2 ) 168 - 182 .
Mavrommati I, Maffucci T ( 2011 ) . mTOR inhibitors: facing new challenges ahead . Curr Med Chem vol. 18 , ( 18 ) 2743 - 2762 .
Edling CE, Selvaggi F, Buus R, Maffucci T, Di Sebastiano P, Friess H, Innocenti P, Kocher HM et al. ( 2010 ) . Key role of phosphoinositide 3-kinase class IB in pancreatic cancer . Clin Cancer Res vol. 16 , ( 20 ) 4928 - 4937 .
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A et al. ( 2010 ) . Pseudoislets as primary islet replacements for research . Islets report no. Islets 2(4) ,
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A et al. ( 2010 ) . Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK . Islets vol. 2 , ( 4 ) 236 - 239 .
Falasca M, Chiozzotto D, Godage HY, Mazzoletti M, Riley AM, Previdi S, Potter BVL, Broggini M et al. ( 2010 ) . A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate . Br J Cancer vol. 102 , ( 1 ) 104 - 114 .
Raimondi C, Maffucci T, Potter BVI, Falasca M ( 2010 ) . A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth . BREAST CANCER RESEARCH . vol. 12 , S3 - S3 .
Abbott J, Pineiro R, Oliviero MA, Lattanzio R, Piantelli M, Bilancio A, Maffucci T, Falasca M ( 2010 ) . Phosphoinositide 3-kinase class II beta is a novel target in breast cancer therapy . BREAST CANCER RESEARCH . vol. 12 , S5 - S5 .
Maffucci T, Raimondi C, Abu-Hayyeh S, Dominguez V, Sala G, Zachary I, Falasca M ( 2009 ) . A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation . PLoS One vol. 4 , ( 12 )
Falasca M, Maffucci T ( 2009 ) . Rethinking phosphatidylinositol 3-monophosphate . Biochim Biophys Acta vol. 1793 , ( 12 ) 1795 - 1803 .
Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M et al. ( 2008 ) . Phospholipase Cgamma1 is required for metastasis development and progression . Cancer Res vol. 68 , ( 24 ) 10187 - 10196 .
Tibolla G, Norata GD, Pineiro R, Maffucci T, Falasca M, Catapano AL ( 2008 ) . 124 PRO-ANGIOGENIC ACTIVITY OF HDL3 AND SPHINGOSINE 1-PHOSPHATE REQUIRES THE SYNERGIC ACTIVATION OF CLASS IB AND CLASS II PHOSPHATIDYLINOSITOL 3-KINASES . Nutrition Metabolism and Cardiovascular Diseases vol. 18 ,
Falasca M, Hughes WE, James DE, Shepherd PR, Dominguez V, Maffucci T ( 2008 ) . Class II phosphoinositide 3-kinase in insulin resistance . DIABETIC MEDICINE . vol. 25 ,
Falasca M, Hughes WE, Dominguez V, Sala G, Fostira F, Fang MQ, Cazzolli R, Shepherd PR et al. ( 2007 ) . The role of phosphoinositide 3-kinase C2alpha in insulin signaling . J Biol Chem vol. 282 , ( 38 ) 28226 - 28236 .
Falasca M, MAFFUCCI T, Fostira F, Sala G, Dominguez V, Hughes WE, James DE, Fang MQ et al. ( 2007 ) . The role of phosphoinositide 3-kinase C2alpha in insulin signaling . Journal of Biological Chemistry vol. 282 , ( 38 ) 28226 - 28236 .
Maffucci T, Falasca M ( 2007 ) . Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma . Biochem Soc Trans . vol. 35 , 229 - 230 .
Falasca M, Maffucci T ( 2007 ) . Role of class II phosphoinositide 3-kinase in cell signalling . Biochem Soc Trans . vol. 35 , 211 - 214 .
Falasca M, Maffucci T ( 2006 ) . Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger . Arch Physiol Biochem vol. 112 , ( 4-5 ) 274 - 284 .
Maffucci T, Piccolo E, Cumashi A, Iezzi M, Riley AM, Saiardi A, Godage HY, Rossi C et al. ( 2005 ) . Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects . Cancer Res vol. 65 , ( 18 ) 8339 - 8349 .
Maffucci T, Cooke FT, Foster FM, Traer CJ, Fry MJ, Falasca M ( 2005 ) . Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration . J Cell Biol vol. 169 , ( 5 ) 789 - 799 .
( 2004 ) . 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 . Diabetologia . vol. 47 , A1 - A464 .
Falasca M, Maffucci T ( 2004 ) . Phosphatidylinositol-3-phosphate, a new crucial player in insulin signalling, is generated via a TC10-mediated phosphoinositide 3-kinase C2alpha activation . DIABETOLOGIA . vol. 47 , A68 - A69 .
Piccolo E, Vignati S, Maffucci T, Innominato PF, Riley AM, Potter BVL, Pandolfi PP, Broggini M et al. ( 2004 ) . Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway . Oncogene vol. 23 , ( 9 ) 1754 - 1765 .
Maffucci T, Brancaccio A, Piccolo E, Stein RC, Falasca M ( 2003 ) . Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation . EMBO J vol. 22 , ( 16 ) 4178 - 4189 .
Maffucci T, Razzini G, Ingrosso A, Chen H, Iacobelli S, Sciacchitano S, Quon MJ, Falasca M ( 2003 ) . Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3 . Mol Endocrinol vol. 17 , ( 8 ) 1568 - 1579 .
Piccolo E, Innominato PF, Mariggio MA, Maffucci T, Iacobelli S, Falasca M ( 2002 ) . The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration . Oncogene vol. 21 , ( 42 ) 6520 - 6529 .
Marra P, Maffucci T, Daniele T, Tullio GD, Ikehara Y, Chan EK, Luini A, Beznoussenko G et al. ( 2001 ) . The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment . Nat Cell Biol vol. 3 , ( 12 ) 1101 - 1113 .
Marra P, Maffucci T, Daniele T, Di Tullio G, Ikehara Y, Chan EKL, Luini A, Mironov A et al. ( 2001 ) . The Golgi matrix proteins GM130 and GRASP65 cycle through a novel subdomain of the intermediate compartment . MOL BIOL CELL vol. 12 , 208A - 208A .
Innominato PF, Mariggio' MA, Piccolo E, Maffucci T, Iacobelli S, Falasca M ( 2001 ) . The mechanism involved in the regulation of PLC gamma 1 activity in cell migration . CLIN CANCER RES vol. 7 , ( 11 ) 3780S - 3780S .
Maffucci T, Falasca M ( 2001 ) . Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism . FEBS Lett vol. 506 , ( 3 ) 173 - 179 .