Publications: Prof Martin Knight

Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM, Gupta HS ( 2024 ) . Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit . Advanced Sciencee2407649 - e2407649 .

Allen O, Knight MM, Verbruggen SW ( 2024 ) . Air Pollution and Osteoporosis . Current Osteoporosis Reports

Gupta H, Snow T, Terrill N, Knight M, Badar W, Fratzl P ( 2024 ) . Data (SAXS and mechanical data) for W. Badar et al "Nonlinear Stress-induced Transformations in Collagen Fibrillar Organisation, Disorder and Strain Mechanisms In The Bone-Cartilage Unit"" .

Gupta H, Badar W, Knight M, Terrill N, Snow T, Fratzl P ( 2024 ) . Data used in the paper "Nonlinear Stress-induced Transformations in Collagen Fibrillar Organisation, Disorder and Strain Mechanisms In The Bone-Cartilage Unit" by W. Badar et al .

Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT et al. ( 2024 ) . A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer . Advanced Healthcare Materials vol. 13 , ( 17 )

Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM ( 2023 ) . A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells . Advanced Science vol. 11 , ( 2 ) 2305842 - 2305842 .

Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT, Knight MM ( 2023 ) . Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment . Biomedical Materials vol. 18 , ( 6 )

Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW ( 2023 ) . Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK . Cancers vol. 15 , ( 3 )

Meng H, Thompson CL, Coveney CR, Wann AK, Knight MM ( 2022 ) . Techniques for Visualization and Quantification of Primary Cilia in Chondrocytes . Cartilage Tissue Engineering , vol. 2598 , Springer Nature

Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM ( 2022 ) . YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression . Osteoarthritis and Cartilage vol. 31 , ( 5 ) 600 - 612 .

Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL ( 2022 ) . Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion . npj Breast Cancer vol. 8 , ( 1 )

Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P et al. ( 2022 ) . Collagen pre-strain discontinuity at the bone—Cartilage interface . PLOS ONE vol. 17 , ( 9 )

Heywood HK, Gardner L, Knight MM, Lee DA ( 2022 ) . Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems . In vitro models1 - 8 .

Gupta H, Badar W, Knight M ( 2022 ) . BCU static scanning data sets .

Inamdar SR, Prévost S, Terrill NJ, Knight MM, Gupta HS ( 2021 ) . Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage . Acta Biomaterialia vol. 136 , 314 - 326 .

Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . Cancer Research . vol. 81 , 2642 - 2642 .

Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM ( 2021 ) . Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype . Cancers vol. 13 , ( 12 )

Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al. ( 2021 ) . A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion . iScience vol. 24 , ( 6 )

Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . iScience vol. 24 , ( 6 )

Thompson C, Mcfie M, Chapple J, BEALES P, Knight M ( 2021 ) . Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation . International Journal of Molecular Sciences

Wu H, Wang Z, Liu S, Meng H, Liu S, Shelton JC, Thompson CL, Fu S et al. ( 2021 ) . Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening . Biochem Biophys Res Commun

Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD ( 2021 ) . Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models . Frontiers in Bioengineering and Biotechnology vol. 9 ,

Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . biorxiv.org

Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson CL, Knight MM ( 2021 ) . Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction . OSTEOARTHRITIS AND CARTILAGE vol. 29 , ( 1 ) 89 - 99 .

Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Using 3-Dimensional <i>in vitro</i> models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . CANCER RESEARCH . vol. 81 ,

Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD ( 2020 ) . Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models . Frontiers in Bioengineering and Biotechnology vol. 8 ,

Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM et al. ( 2020 ) . Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films . ACS nano vol. 14 , ( 9 ) 11029 - 11039 .

Torres-Pérez JV, Naeem H, Thompson CL, Knight MM, Novak P ( 2020 ) . Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia . Cellular Physiology and Biochemistry vol. 54 , ( 1 ) 15 - 26 .

Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM ( 2019 ) . Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β . Clinical Biomechanics vol. 79 ,

Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM et al. ( 2019 ) . Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model . Nature Communications vol. 10 , ( 1 )

Inamdar SR, Barbieri E, Terrill NJ, Knight MM, Gupta HS ( 2019 ) . Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage . Acta Biomaterialia vol. 97 , 437 - 450 .

Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K et al. ( 2019 ) . Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression . Cancers

Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT et al. ( 2019 ) . Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation . Osteoarthritis and Cartilage vol. 27 , ( 7 ) 1064 - 1074 .

Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B et al. ( 2019 ) . An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation . Journal of Biomechanics

O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al. ( 2019 ) . Oncometabolite induced primary cilia loss in pheochromocytoma . Endocrine-Related Cancer vol. 26 , ( 1 ) 165 - 180 .

Delaine-Smith R, Wright N, Hanley CJ, Hanwell R, Bhome R, Bullock M, Drifka CR, Eliceiri KW et al. ( 2019 ) . Transglutaminase-2 mediates stromal biomechanics in colorectal cancer . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 100 , A15 - A16 .

Rowson DT, Shelton JC, Screen HRC, Knight MM ( 2018 ) . Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6 . Scientific Reports vol. 8 , ( 1 )

Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC ( 2018 ) . Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages . European Cells and Materials vol. 36 , 142 - 155 .

Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT ( 2018 ) . Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling . Journal of Cell Science vol. 131 , ( 10 ) Article jcs215780 , 215780 - 215780 .

Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al. ( 2018 ) . Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression . Acta Biomater vol. 72 , 434 - 446 .

Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. ( 2018 ) . Investigating drivers of the tumour matrisome, and their role in disease progression . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 99 , A49 - A49 .

Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov

Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al. ( 2017 ) . Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling . Eur Cell Mater vol. 34 , 128 - 141 .

Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM, Gupta HS ( 2017 ) . The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage . ACS Nano

Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA et al. ( 2017 ) . Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis . Acta Biomater vol. 57 , 487 - 497 .

Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M ( 2017 ) . Abstract 5558: Deconstruction of a human tumor microenvironment . Cancer Research . vol. 77 , 5558 - 5558 .

Bader DL, Lee DA, Knight MM ( 2017 ) . Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2) . The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME vol. 2005.18 , ( 0 ) 2 - 3 .

Harris C, Rushwan S, Wang W, Thorpe S, Thompson C, Peacock J, Knight M, Gooptu B et al. ( 2017 ) . P07 Interleukin response to cyclical mechanical stretch with models of different neonatal ventilation modes . Archives of Disease in Childhood . Conference: Plenary vol. 102 ,

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL et al. ( 2017 ) . Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria . Journal of Cellular Physiology vol. 232 , ( 11 ) 3103 - 3111 .

THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM ( 2017 ) . Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria . Journal of Cellular Physiology

Gooptu B, Rushwan S, Wang W, Harris C, Thorpe S, Knight M, Sethi T ( 2017 ) . A Cd98hc-Dependent Mechanism Mediates Pro-Inflammatory Cytokine Release In Cell And Animal Models Of Lung Injury . AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE . vol. 195 ,

Rowson DT, Knight MM, Screen HRC ( 2017 ) . Cyclic loading leads to primary cilia disassembly in human tenocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A6 - A6 .

Thompson CL, Chapple JP, Beales PL, Mitchison HM, Ramachandran M, Knight MM ( 2017 ) . Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A14 - A14 .

Knight MM ( 2017 ) . Primary cilia mechanobiology . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 98 , A3 - A4 .

Delaine-Smith RM, Burney S, Balkwill FR, Knight MM ( 2016 ) . Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics . Journal of the Mechanical Behavior of Biomedical Materials vol. 60 , 401 - 415 .

Sliogeryte K, Botto L, Lee DA, Knight MM ( 2016 ) . Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion . Osteoarthritis and Cartilage vol. 24 , ( 5 ) 912 - 920 .

Thorpe SD, Gambassi S, Patel R, Santucci A, Knight MM ( 2016 ) . Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria . Osteoarthritis and Cartilage . vol. 24 , s174 - s175 .

Kelly T-AN, Thompson CL, Tan E, Wann AK, Thorpe SD, Chapple JP, Hung CT, Knight MM ( 2016 ) . Chondrocyte dedifferentiation down regulates mechano-responsiveness and hedgehog signalling associated with changes in primary cilia structure . Osteoarthritis and Cartilage . Conference: World Congress of the Osteoarthritis-Research-Society-International (OARSI) on Osteoarthritis from: 31/03/2016 to: 03/04/2016 , vol. 24 , S342 - S343 .

Rowson D, Knight MM, Screen HRC ( 2016 ) . Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon . J Orthop Res vol. 34 , ( 12 ) 2146 - 2153 .

Thompson CL, Wiles A, Poole CA, Knight MM ( 2016 ) . Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling . FASEB Journal vol. 30 , ( 2 ) 716 - 726 .

Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM ( 2016 ) . Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration . Journal of Biomechanics vol. 49 , ( 2 ) 310 - 317 .

Knight M, Buchholz N, Bourdoumis A ( 2016 ) . Physiology of urethral flow . Handbook of Urinary Stents: Basic Science and Clinical Applications , Jaypee Brothers Medical Publishing

Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP, Knight MM ( 2015 ) . Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β . Arthritis Research & Therapy vol. 17 , ( 1 )

Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL et al. ( 2015 ) . Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult . Arthritis Res Ther vol. 17 , 361 - 361 .

Thompson CL, Poole CA, Knight MM ( 2015 ) . Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling . The FASEB Journal vol. 100 , ( 4 ) A39 - A40 .

Wang Z, Wann AKT, Thompson CL, Hassen A, Wang W, Knight MM ( 2015 ) . IFT88 influences chondrocyte actin organization and biomechanics . Osteoarthritis and cartilage vol. 24 , ( 3 ) 544 - 554 .

CHEN J, BADER DL, LEE DA, KNIGHT MM ( 2015 ) . FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD . Journal of Mechanics in Medicine and Biology vol. 15 , ( 05 )

KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A, Poole CA ( 2015 ) . Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties . Journal of Orthopaedic Research

Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM ( 2015 ) . Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation . Stem Cells vol. 33 , ( 6 ) 1952 - 1961 .

Sliogeryte K, Thorpe SD, Lee DA, Botto L, Knight MM ( 2014 ) . Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics . Scientific Reports vol. 4 , ( 1 )

Wang Z, Irianto J, Kazun S, Wang W, Knight MM ( 2014 ) . The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes . Osteoarthritis and Cartilage vol. 23 , ( 2 ) 289 - 299 .

Rowson D, Knight M, Screen H ( 2014 ) . 89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix . British Journal of Sports Medicine vol. 48 , ( Suppl 2 ) a58 - a59 .

Wann AKT, Chapple JP, Knight MM ( 2014 ) . The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity . Cell Signal vol. 26 , ( 8 ) 1735 - 1742 .

Thompson CL, Chapple JP, Knight MM ( 2014 ) . Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes . Osteoarthritis Cartilage vol. 22 , ( 3 ) 490 - 498 .

Irianto J, Lee DA, Knight MM ( 2014 ) . Quantification of chromatin condensation level by image processing . Med Eng Phys vol. 36 , ( 3 ) 412 - 417 .

Irianto J, Ramaswamy G, Serra R, Knight MM ( 2014 ) . Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage . J Biomech vol. 47 , ( 2 ) 579 - 582 .

Shaheen T, Edirisinghe T, Gabriel M, Bourdoumis A, Buchholz N, Knight M ( 2014 ) . In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model . UROLITHIASIS vol. 42 , ( 3 ) 203 - 207 .

Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP ( 2013 ) . Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope . PLOS ONE vol. 8 , ( 12 )

McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM ( 2013 ) . Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells . Sci Rep vol. 3 ,

Wann AK, Thompson CL, Chapple JP, Knight MM ( 2013 ) . Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium . Cilia vol. 2 , ( 1 )

Shafat M, Rajakumar K, Syme H, Buchholz N, Knight MM ( 2013 ) . Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference? . Urolithiasis vol. 41 , ( 6 ) 481 - 486 .

Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA ( 2013 ) . Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes . Biophys J vol. 104 , ( 4 ) 759 - 769 .

Hernandez-Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales PL ( 2013 ) . Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization . HUMAN MOLECULAR GENETICS vol. 22 , ( 19 ) 3858 - 3868 .

Hosny NA, Song M, Knight MM, Wheeler AP ( 2013 ) . Super-resolution imaging strategies for Cell Biologists using a spinning disk microscope . MOLECULAR BIOLOGY OF THE CELL vol. 24 ,

Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP ( 2013 ) . Super-resolution imaging strategies for cell biologists using a spinning disk microscope . PLoS One vol. 8 , ( 10 )

Knight MM ( 2013 ) . THE ROLE OF PRIMARY CILIA IN CARTILAGE HEALTH AND DISEASE . OSTEOARTHRITIS AND CARTILAGE . vol. 21 , S2 - S2 .

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP ( 2012 ) . Heat shock induces rapid resorption of primary cilia . Development vol. 139 , ( 24 ) e2408 - e2408 .

Wann AKT, Thompson C, Knight MM ( 2012 ) . The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading . Mechanically Gated Channels and their Regulation , Springer Nature

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL, Chapple JP ( 2012 ) . Heat shock induces rapid resorption of primary cilia . Journal of Cell Science vol. 125 , ( 18 ) 4297 - 4305 .

Wann A, Knight M ( 2012 ) . A role for IFT88/the primary cilium in the inflammatory response to interleukin-1 . Cilia vol. 1 , ( Suppl 1 )

Hernandez V, Pravincumar P, Diaz-Font A, May-Simera H, Jenkins D, Knight M, Beales P ( 2012 ) . Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation . Cilia vol. 1 , ( Suppl 1 )

Thompson C, Prodromou N, Osborn D, Ashworth R, Knight M, Beales P, Chapple J ( 2012 ) . Heat-shock induces rapid resorption of primary cilia . Cilia vol. 1 , ( Suppl 1 )

Thompson C, Chapple J, Knight M ( 2012 ) . Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes . Cilia vol. 1 , ( Suppl 1 )

Wann A, Zuo N, Haycraft C, Jensen C, Poole C, McGlashan S, Knight M ( 2012 ) . The primary cilium conducts chondrocyte mechanotransduction . Cilia vol. 1 , ( Suppl 1 )

McMurray R, Knight M ( 2012 ) . Topographical regulation of primary cilia orientation and length in mesenchymal stem cells . Cilia vol. 1 , ( Suppl 1 )

Wheeler APS, Morad S, Buchholz N, Knight MM ( 2012 ) . The Shape of the Urine Stream - From Biophysics to Diagnostics . PLoS ONE vol. 7 , ( 10 )

Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL, Knight MM ( 2012 ) . Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment . Biophysical Journal vol. 103 , ( 6 ) 1188 - 1197 .

Pravincumar P, Bader DL, Knight MM ( 2012 ) . Viscoelastic Cell Mechanics and Actin Remodelling Are Dependent on the Rate of Applied Pressure . PLoS ONE vol. 7 , ( 9 )

Wann AKT, Knight MM ( 2012 ) . Primary cilia elongation in response to interleukin-1 mediates the inflammatory response . Cellular and Molecular Life Sciences vol. 69 , ( 17 ) 2967 - 2977 .

Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL, Stevens MM ( 2012 ) . Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: A case study . Journal of the Mechanical Behavior of Biomedical Materials vol. 11 , 72 - 81 .

Pravincumar P, Bader D, Knight M ( 2012 ) . PRESSURE RATE SENSITIVE VISCOELASTIC CELL DEFORMATION INVOLVES ACTIN REMODELLING . Journal of Biomechanics vol. 45 ,

Wann AKT, Zuo N, Haycraft CJ, Jensen CG, Poole CA, McGlashan SR, Knight MM ( 2012 ) . Primary cilia mediate mechanotransduction through control of ATP-induced Ca²⁺ signaling in compressed chondrocytes . FASEB Journal vol. 26 , ( 4 ) 1663 - 1671 .

Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV et al. ( 2012 ) . Improved outcome after peripheral nerve injury in mice with increased levels of endogenous Omega-3 polyunsaturated fatty acids . Journal of Neuroscience vol. 32 , ( 2 ) 563 - 571 .

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA ( 2012 ) . Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading . Biomechanics and Modeling in Mechanobiology vol. 11 , ( 3-4 ) 439 - 447 .

Thompson CL, Prodromou NV, Osborn DP, Ashworth R, Knight MM, Beales PL, Chapple JP ( 2012 ) . Heat-shock induces rapid resorption of primary cilia . Cilia vol. 1 , ( Suppl 1 ) P52 - P52 .

Hosny NA, Lee DA, Knight MM ( 2012 ) . Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations . Journal of Biomedical Optics vol. 17 , ( 1 )

McMurray R, Knight MM ( 2012 ) . Topographical regulation of primary cilia orientation and length in mesenchymal stem cells . Cilia vol. 1 , ( Suppl 1 ) P34 - P34 .

Gladman S, Lim SN, Dyall S, Knight MM, Priestley JV, Michael-Titus AT ( 2011 ) . Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation . OCL - Oleagineux Corps Gras Lipides vol. 18 , ( 6 ) 317 - 323 .

Shafat M, Nedilko T, Syme H, Buchholz N, Knight MM ( 2011 ) . E189 Does the composition of feline urine prevent calcium oxalate encrustation of urethral stents? . European Urology Open Science vol. 10 , ( 7 ) 517 - 518 .

Edirisinghe TY, Knight MM, Buchholz N, Bach C ( 2011 ) . E70 The influence of extracorporeal shock wave lithotripsy on tissue viability around metallic ureteral stents . European Urology Open Science vol. 10 , ( 7 )

Nedilko T, Paulose PA, Buchholz N, Knight MM ( 2011 ) . E75 Comparison of encrustation rates between ureteric metal stents and Double J stents . European Urology Open Science vol. 10 , ( 7 )

Gabriel CEL, Nedilko T, Paulose PA, Bach C, Buchholz N, Knight MM ( 2011 ) . E84 Can Shockwave lithotripsy remove encrustation from ureteric nitinol stents? . European Urology Open Science vol. 10 , ( 7 )

Maeda E, Ye S, Wang W, Bader DL, Knight MM, Lee DA ( 2011 ) . Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading . Biomechanics and Modeling in Mechanobiology1 - 9 .

Lee DA, Knight MM, Campbell JJ, Bader DL ( 2011 ) . Stem cell mechanobiology . Journal of Cellular Biochemistry vol. 112 , ( 1 ) 1 - 9 .

Gladman SJ, Ward RE, Michael-Titus AT, Knight MM, Priestley JV ( 2010 ) . The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro . Neuroscience vol. 171 , ( 2 ) 577 - 587 .

Vaughan NM, Grainger J, Bader DL, Knight MM ( 2010 ) . The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures . Medical and Biological Engineering and Computing vol. 48 , ( 12 ) 1215 - 1222 .

Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM ( 2010 ) . Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation . Arthritis Research and Therapy vol. 12 , ( 6 )

Heywood HK, Knight MM, Lee DA ( 2010 ) . Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates . Journal of Cellular Physiology vol. 223 , ( 3 ) 630 - 639 .

Ye S, Maeda E, Knight M, Lee D, Bader D, Wang W ( 2010 ) . A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles . The FASEB Journal vol. 24 , ( S1 ) 975.9 - 975.9 .

Garcia M, Knight MM ( 2010 ) . Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway . Journal of Orthopaedic Research vol. 28 , ( 4 ) 510 - 515 .

Maeda E, Ye S, Knight M, Wang W, Bader D, Lee D ( 2010 ) . 1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan) . Seibutsu Butsuri vol. 50 , ( supplement2 )

Bader DL, Knight MM ( 2010 ) . 4 Measuring the biomechanical properties of cartilage cells . Regenerative Medicine and Biomaterials for the Repair of Connective Tissues , Elsevier

Archer C, Ralphs J, Säämänen A-M, Arokoski JPA, Jurvelin JS, Kiviranta I, Hinz B, Hunziker EB et al. ( 2010 ) . Contributor contact details . Regenerative Medicine and Biomaterials for the Repair of Connective Tissues , Elsevier

Bader DL, Knight MM ( 2010 ) . Measuring the biomechanical properties of cartilage cells . 106 - 136 .

McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA ( 2010 ) . Mechanical loading modulates chondrocyte primary cilia incidence and length . Cell Biology International vol. 34 , ( 5 ) 441 - 446 .

Knight MM, Mcglashan SR, Garcia M, Jensen CG, Poole CA ( 2009 ) . Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium? . Journal of Anatomy vol. 214 , ( 2 ) 275 - 283 .

Bader DL, Knight MM ( 2008 ) . Biomechanical analysis of structural deformation in living cells . Medical and Biological Engineering and Computing vol. 46 , ( 10 ) 951 - 963 .

Pingguan-Murphy B, Knight MM ( 2008 ) . Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytes . Mechanosensitive Ion Channels , Springer Nature

Campbell JJ, Blain EJ, Chowdhury TT, Knight MM ( 2007 ) . Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes . Biochemical and Biophysical Research Communications vol. 361 , ( 2 ) 329 - 334 .

KNIGHT MM, Chowdhury TT, Campbell JJ, Blain EJ ( 2007 ) . Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes . Biochemical and Biophysical Research Communications vol. 361 , ( 21 ) 329 - 334 .

Campbell JJ, Knight MM ( 2007 ) . An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers . Microscopy Research and Technique vol. 70 , ( 12 ) 1034 - 1040 .

Chowdhury TT, Knight MM ( 2006 ) . Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression . Journal of Cellular Physiology vol. 209 , ( 3 ) 845 - 853 .

Pingguan-Murphy B, El-Azzeh M, Bader DL, Knight MM ( 2006 ) . Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner . Journal of Cellular Physiology vol. 209 , ( 2 ) 389 - 397 .

Bomzon Z, Knight MM, Bader DL, Kimmel E ( 2006 ) . Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm . Journal of Biomechanical Engineering vol. 128 , ( 5 ) 674 - 679 .

Hakimi O, Knight DP, Knight MM, Grahn MF, Vadgama P ( 2006 ) . Ultrastructure of insect and spider cocoon silks . Biomacromolecules vol. 7 , ( 10 ) 2901 - 2908 .

Ohashi T, Hagiwara M, Bader DL, Knight MM ( 2006 ) . Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration . Biorheology vol. 43 , ( 3-4 ) 201 - 214 .

Knight MM, Toyoda T, Lee DA, Bader DL ( 2006 ) . Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . Journal of Biomechanics vol. 39 , ( 8 ) 1547 - 1551 .

Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL ( 2006 ) . Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields . Biomechanics and Modeling in Mechanobiology vol. 5 , ( 2-3 ) 180 - 191 .

Bomzon Z, Knight MM, Bader DL, Kimmel E ( 2006 ) . Probing mechanical heterogeneity in chondrocytes using passive microtheology . Journal of Biomechanics vol. 39 ,

Pingguan-Murphy B, Lee DA, Bader DL, Knight MM ( 2005 ) . Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles . Archives of Biochemistry and Biophysics vol. 444 , ( 1 ) 45 - 51 .

Sawae Y, Shelton JC, Bader DL, Knight MM ( 2004 ) . Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear . Ann Biomed Eng vol. 32 , ( 6 ) 860 - 870 .

Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM ( 2004 ) . Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage . Osteoarthritis Cartilage vol. 12 , ( 1 ) 17 - 24 .

Lee DA, Knight MM ( 2004 ) . Mechanical Loading of Chondrocytes Embedded in 3D Constructs . Cartilage and Osteoarthritis , vol. 100 , Springer Nature

Lee DA, Knight MM ( 2004 ) . Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain . Methods in molecular medicine vol. 100 , 307 - 324 .

Knight MM, Roberts SR, Lee DA, Bader DL ( 2003 ) . Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death . Am J Physiol Cell Physiol vol. 284 , ( 4 ) C1083 - C1089 .

Bader DL, SHELTON JC, Knight MM, Sawae Y ( 2003 ) . Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear . J Biochemical Engineering ASME

Knight MM, Roberts SR, Lee DA, Bader DL ( 2002 ) . Light-induced calcium signalling in chondrocytes . European Cells and Materials . vol. 4 , 7 - 8 .

Knight MM, Toyoda T, Bader DL, Lee DA ( 2002 ) . Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products .

Holloway I, Knight MM, Lee DA, Bader DL, Bentley G ( 2002 ) . Changes in cell morphology and cytoskeletal organisation in osteoarthric cartilage . European Cells and Materials . vol. 4 , 52 - 53 .

Bader DL, Ohashi T, Knight MM, Lee DA, Sato M ( 2002 ) . Deformation properties of articular chondrocytes: A critique of three separate techniques . Biorheology . vol. 39 , 69 - 78 .

Knight MM, Van De Breevaart Bravenboer J, Lee DA, Van Osch GJVM, Weinans H, Bader DL ( 2002 ) . Cell and nucleus deformation in compressed chondrocyte-alginate constructs: Temporal changes and calculation of cell modulus . Biochimica et Biophysica Acta - General Subjects vol. 1570 , ( 1 ) 1 - 8 .

Holloway I, Knight MM, LEE DA, Bader DL, Bentley G ( 2002 ) . Characterisation of cell morphology, cytoskeletal organization and apoptosis in human osteoarthritic cartilage . Trans. Orthop. Res. Soc . Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27 ,

Knight MM, Roberts SR, LEE DA, Bader DL ( 2002 ) . Light-induced calcium signalling in chondrocytes . Eur. Cells Materials . Conference: TCES 2002 Annual meeting of the UK Tissue and Cell Engineering Society ( University of Glasgow, Scotland ) from: 19/09/2002 to: 20/09/2002 , vol. 4 , 7 - 8 .

Knight MM, Toyoda T, LEE DA, Bader DL ( 2002 ) . Mechanical strain and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose . Trans. Orthop. Res. Soc. . Conference: 48th Annual Meeting of the Orthopaedic Research Society vol. 27 , 35 - 35 .

Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA ( 2001 ) . Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose . Biochim Biophys Acta vol. 1526 , ( 2 ) 141 - 146 .

Knight MM, Idowu BD, Lee DA, Bader DL ( 2001 ) . Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique . Med Biol Eng Comput vol. 39 , ( 3 ) 397 - 404 .

Bouten CVC, Knight MM, Lee DA, Bader DL ( 2001 ) . Compressive deformation and damage of muscle cell subpopulations in a model system . ANN BIOMED ENG vol. 29 , ( 2 ) 153 - 163 .

LEE DA, Idowu BD, Knight MM, Bader DL ( 2001 ) . Mechanical compression influences cytoskeletal oragnisation within chondrocytes seeded in agarose constructs . Trans. Orthop. Res. Soc. . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 263 - 263 .

Roberts SR, Knight MM, Lee DA, Bader DL ( 2001 ) . Mechanical compression influences intracellular Ca²⁺ signaling in chondrocytes seeded in agarose constructs . Journal of Applied Physiology vol. 90 , ( 4 ) 1385 - 1391 .

Knight MM, van de Breevaart Brevenboer J, van Osch G, Weinans H, LEE DA, Bader DL ( 2001 ) . Temporal changes in cell and nucleus deformation in isolated chondrocytes compressed in alginate scaffolds . Trans. Orthop. Res. Soc. . Conference: 47th Annual Meeting, Orthopaedic Research Society ( San Francisco, California ) from: 25/02/2001 to: 28/02/2001 , vol. 26 , 611 - 611 .

Knight MM, Van De Breevaart Bravenboer J, Bader DL, Lee DA ( 2000 ) . Compression induced cell and nucleus deformation in chondrocyte-alginate constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling .

Roberts SR, Knight MM, Lee DA, Bader DL ( 2000 ) . Intracellular - CA2+ signalling in compressed chondrocyte agarose constructs . Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling .

Idowu BD, Knight MM, Bader DL, Lee DA ( 2000 ) . Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose . Histochemical Journal vol. 32 , ( 3 ) 165 - 174 .

Roberts SR, Knight MM, Lee DA, Bader DL ( 2000 ) . Intracellular calcium signalling in compressed chondrocyte agarose constructs . J PHYSIOL-LONDON . vol. 523 , 12P - 12P .

Knight DP, KNIGHT MM, Vollrath F ( 2000 ) . Beta transition and stress-induced phase separation in the spinning of spider dragline silk . International Journal of Biological Macromolecules vol. 27 , ( 3 ) 205 - 210 .

Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL ( 2000 ) . Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels . J Biomech vol. 33 , ( 1 ) 81 - 95 .

Hing K, Knight M ( 1998 ) . Prize-winning peeks at the microscopic world .

Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL ( 1998 ) . Response of chondrocyte subpopulations cultured within unloaded and loaded agarose . J Orthop Res vol. 16 , ( 6 ) 726 - 733 .

Knight MM, Lee DA, Bader DL ( 1998 ) . The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose . Biochim Biophys Acta vol. 1405 , ( 1-3 ) 67 - 77 .

Knight MM, Ghori SA, Lee DA, Bader DL ( 1998 ) . Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression . Medical Engineering and Physics vol. 20 , ( 9 ) 684 - 688 .