Publications: Prof Charles Knowles
Vollebregt PF, Knowles CH, Scott SM
(
2023
)
.
Letter: opioid usage is associated with rectal hyposensitivity in patients with opioid-induced constipation
.
Alimentary Pharmacology and Therapeutics
vol.
57
,
(
4
)
448
-
449
.
Bharucha AE, Knowles CH, Mack I, Malcolm A, Oblizajek N, Rao S, Scott SM, Shin A et al.
(
2022
)
.
Faecal incontinence in adults
.
Nature Reviews Disease Primers
vol.
8
,
(
1
)
Grossi U, Lacy-Colson J, Brown SR, Cross S, Eldridge S, Jordan M, Mason J, Norton C et al.
(
2022
)
.
Stepped-wedge randomized controlled trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation
.
Techniques in Coloproctology
vol.
26
,
(
12
)
941
-
952
.
Knowles CH
(
2022
)
.
Trials with repeated cross sections: alternatives to parallel group designs in surgery trials
.
Techniques in Coloproctology
vol.
26
,
(
12
)
929
-
930
.
Bharucha AE, Knowles CH
(
2022
)
.
Rectocele: Incidental or important? Observe or operate? Contemporary diagnosis and management in the multidisciplinary era
.
Neurogastroenterology and Motility
vol.
34
,
(
11
)
Chaichanavichkij P, Hartmann M, McLachlan S, Scott SM, Fenton N, Knowles CH
(
2022
)
.
O039 Evaluating the influence of risk factors on the development of defaecatory problems: a Delphi study
.
British Journal of Surgery
vol.
109
,
(
SUPPL 4
)
Vollebregt PF, Wiklendt L, Burgell RE, Chaichanavichkij P, Dinning PG, Knowles CH, Scott SM
(
2022
)
.
Abnormal Perception of Urge to Defecate: An Important Pathophysiological Mechanism in Women With Chronic Constipation
.
American Journal of Gastroenterology
vol.
117
,
(
7
)
1125
-
1136
.
Vollebregt PF, Dinning PG, Knowles CH, Scott SM
(
2022
)
.
Coexistent faecal incontinence and constipation: Common but frequently overlooked
.
United European Gastroenterology Journal
vol.
10
,
(
6
)
601
-
602
.
Kouli O, Murray V, Bhatia S, Cambridge WA, Kawka M, Shafi S, Knight SR, Kamarajah SK et al.
(
2022
)
.
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
.
The Lancet Digital Health
vol.
4
,
(
7
)
e520
-
e531
.
Howell CA, Kemppinen A, Allgar V, Dodd M, Knowles CH, Mclaughlin J, Pandya P, Whorwell P et al.
(
2022
)
.
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D)
.
Gut
vol.
71
,
(
12
)
2430
-
2438
.
Desprez C, Danovi D, Knowles C, Day R
(
2022
)
.
515 CELL SHAPE CHARACTERISTICS OF HUMAN SKELETAL MUSCLE CELLS AS A PREDICTOR OF MYOGENIC COMPETENCY: A NEW PARADIGM TOWARDS PRECISION CELL THERAPY FOR INCONTINENCE
.
Continence
vol.
2
,
Adamina M, Ademuyiwa A, Adisa A, Bhangu AA, Bravo AM, Cunha MF, Emile S, Ghosh D et al.
(
2022
)
.
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
.
Colorectal Disease
vol.
24
,
(
6
)
708
-
726
.
Baidoo N, Crawley E, Knowles CH, Sanger GJ, Belai A
(
2022
)
.
Total collagen content and distribution is increased in human colon during advancing age
.
PLoS ONE
vol.
17
,
(
6 June
)
Vollebregt P, Wiklendt L, Burgell R, Chaichanavichkij P, Dinning P, Knowles C, Scott SM
(
2022
)
.
808: ABNORMAL PERCEPTION OF URGE TO DEFECATE: AN IMPORTANT PATHOPHYSIOLOGICAL MECHANISM IN WOMEN WITH CONSTIPATION
.
Gastroenterology
vol.
162
,
(
7
)
s
-
198
.
Peiris M, Aktar R, Reed D, Cibert-Goton V, Zdanaviciene A, Halder W, Robinow A, Corke S et al.
(
2022
)
.
Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells
.
Gut
vol.
71
,
(
5
)
928
-
937
.
Knowles CH, Dinning P, Mark Scott S, Swash M, de Wachter S
(
2022
)
.
New concepts in the pathophysiology of fecal incontinence
.
Annals of Laparoscopic and Endoscopic Surgery
vol.
7
,
Vollebregt PF, Burgell RE, Knowles CH, Scott SM
(
2022
)
.
Rectal Hyposensitivity Is an Important Pathophysiologic Mechanism in Patients with Constipation: Evidence from Large Observational Studies in Patients Referred for Anorectal Physiology Testing
.
American Journal of Gastroenterology
vol.
117
,
(
4
)
Ang D, Vollebregt P, Carrington EV, Knowles CH, Scott SM
(
2022
)
.
Redundancy in the International Anorectal Physiology Working Group Manometry Protocol: A Diagnostic Accuracy Study in Fecal Incontinence
.
Digestive Diseases and Sciences
vol.
67
,
(
3
)
964
-
970
.
Rasijeff AMP, García-Zermeño K, Di Tanna GL, Remes-Troche J, Knowles CH, Scott MS
(
2022
)
.
Systematic review and meta-analysis of anal motor and rectal sensory dysfunction in male and female patients undergoing anorectal manometry for symptoms of faecal incontinence
.
Colorectal Disease
Knowles CH, Cohen RC
(
2022
)
.
Chronic anal pain: A review of causes, diagnosis, and treatment
.
Cleveland Clinic Journal of Medicine
vol.
89
,
(
6
)
336
-
343
.
Adegbola SO, Sarafian M, Sahnan K, Pechlivanis A, Phillips RKS, Warusavitarne J, Faiz O, Haddow J et al.
(
2022
)
.
Lack of anti-TNF drugs levels in fistula tissue - a reason for nonresponse in Crohn's perianal fistulating disease?
.
European Journal of Gastroenterology and Hepatology
vol.
34
,
(
1
)
18
-
26
.
Ahmed WUR, Bhatia S, McLean KA, Khaw R, Baker D, Kamarajah SK, Bell S, Nepogodiev D et al.
(
2022
)
.
Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
.
BJS Open
vol.
6
,
(
1
)
Knowles CH, Booth L, Brown SR, Cross S, Eldridge S, Emmett C, Grossi U, Jordan M et al.
(
2021
)
.
Non-drug therapies for the management of chronic constipation in adults: the CapaCiTY research programme including three RCTs
.
Glasbey JC, Omar O, Nepogodiev D, Minaya-Bravo A, Bankhead-Kendall BK, Fiore M, Futaba K, Gujjuri RR et al.
(
2021
)
.
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic
.
British Journal of Surgery
vol.
108
,
(
1
)
88
-
96
.
Ng CE, Howell C, Kemppinen A, Forsyth H, Richell G, Markaryan E, McLaughlin J, Knowles C et al.
(
2021
)
.
PWE-61 An early evaluation of participant recruitment and compliance following the virtualisation of RELIEVE IBS-D trial
.
Gut
.
Conference:
Posters
vol.
70
,
a173
-
a174
.
Ng CE, Howell C, Markaryan E, Kemppinen A, Ling J, Newton J, McLaughlin J, Knowles C et al.
(
2021
)
.
PWE-63 Recruitment potential of enhanced IBS trial recruitment strategies in the community
.
Gut
.
Conference:
Posters
vol.
70
,
a175
-
a175
.
Ng CE, Howell C, Markaryan E, Kemppinen A, Ling J, Newton J, McLaughlin J, Knowles C et al.
(
2021
)
.
PWE-64 Understanding factors that affect recruitment to an interventional trial of irritable bowel syndrome
.
Conference:
Postersa175.2
-
a1a176
.
Pinkney TD, Taylor H, Tong C, Schmitz ND, Morton DG, Bhangu A, Blackwell S, Dardanov D et al.
(
2021
)
.
An international assessment of the adoption of enhanced recovery after surgery (ERAS®) principles across colorectal units in 2019–2020
.
Colorectal Disease
vol.
23
,
(
11
)
2980
-
2987
.
Glasbey J, Ademuyiwa A, Adisa A, AlAmeer E, Arnaud AP, Ayasra F, Azevedo J, Minaya-Bravo A et al.
(
2021
)
.
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
.
The Lancet Oncology
vol.
22
,
(
11
)
1507
-
1517
.
Grossi U, Heinrich H, Di Tanna GL, Taylor SA, Vollebregt PF, Knowles CH, Mark Scott S
(
2021
)
.
Systematic Characterization of Defecographic Abnormalities in a Consecutive Series of 827 Patients With Chronic Constipation
.
Diseases of the Colon and Rectum
vol.
64
,
(
11
)
1385
-
1397
.
Heitmann PT, Vollebregt PF, Knowles CH, Lunniss PJ, Dinning PG, Scott SM
(
2021
)
.
Understanding the physiology of human defaecation and disorders of continence and evacuation
.
Nature Reviews Gastroenterology and Hepatology
vol.
18
,
(
11
)
751
-
769
.
Gmel GE, Vollebregt PF, Thijssen MEG, Santos Escapa R, McAlees E, Mugan D, Parker JL, Knowles CH
(
2021
)
.
Electrophysiological Responses in the Human S3 Nerve During Sacral Neuromodulation for Fecal Incontinence
.
Frontiers in Neuroscience
vol.
15
,
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al.
(
2021
)
.
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function
.
Frontiers in Neuroscience
vol.
15
,
747067
-
747067
.
McLean KA, Kamarajah SK, Chaudhry D, Gujjuri RR, Raubenheimer K, Trout I, AlAmeer E, Creagh-Brown B et al.
(
2021
)
.
Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic
.
British Journal of Surgery
vol.
108
,
(
12
)
1448
-
1464
.
Dudding TC, Lehur PA, Sørensen M, Engelberg S, Bertapelle MP, Chartier-Kastler E, Everaert K, Van Kerrebroeck P et al.
(
2021
)
.
Reprogramming Sacral Neuromodulation for Sub-Optimal Outcomes: Evidence and Recommendations for Clinical Practice
.
Neuromodulation
vol.
24
,
(
7
)
1247
-
1257
.
Rabie M, Fowler H, Dudi-Venkata NN, Ayorinde J, Elshami M, Keller DS, Sylla P, Gallo G et al.
(
2021
)
.
Diverticulitis Management, a Snapshot Collaborative Audit Study (DAMASCUS): Protocol for an international, multicentre, prospective observational study
.
Colorectal Disease
vol.
23
,
(
8
)
2182
-
2188
.
Akowuah E, Benson RA, Caruana EJ, Chetty G, Edwards JG, Forlani S, Gradinariu G, Murphy GJ et al.
(
2021
)
.
Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study
.
Journal of Thoracic and Cardiovascular Surgery
vol.
162
,
(
2
)
e355
-
e372
.
ESCP EAGLE Safe Anastomosis Collaborative
(
2021
)
.
ESCP Safe Anastomosis ProGramme in CoLorectal SurgEry (EAGLE): Study protocol for an international cluster randomised trial of a quality improvement intervention to reduce anastomotic leak following right colectomy
.
Colorectal Dis
Scott SM, Simrén M, Farmer AD, Dinning PG, Carrington EV, Benninga MA, Burgell RE, Dimidi E et al.
(
2021
)
.
Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation
.
Neurogastroenterology and Motility
vol.
33
,
(
6
)
Dibley L, Hart A, Duncan J, Knowles CH, Kerry S, Lanz D, Madurasinghe VW, Wade T et al.
(
2021
)
.
Clinician Administered and Self-Report Survey Both Effective for Identifying Fecal Incontinence in Patients with Inflammatory Bowel Disease
.
Digestive Diseases and Sciences
vol.
66
,
(
6
)
2024
-
2031
.
Martin JE, English W, Kendall JV, Sheshappanavar V, Peroos S, West M, Cleeve S, Knowles C
(
2021
)
.
Megarectum: systematic histopathological evaluation of 35 patients and new common pathways in chronic rectal dilatation
.
Journal of Clinical Pathology
vol.
75
,
(
10
)
651
-
657
.
Knowles CH, Walker JA
(
2021
)
.
Caecal volvulus on a background of recurrent caecocolic torsion
.
Annals of the Royal College of Surgeons of England
vol.
103
,
(
5
)
E177
-
E179
.
Chaichanavichkij P, Vollebregt PF, Tee SZY, Scott SM, Knowles CH
(
2021
)
.
Slow-transit constipation and criteria for colectomy: A cross-sectional study of 1568 patients
.
BJS Open
vol.
5
,
(
3
)
Vollebregt PF, Burgell RE, Hooper RL, Knowles CH, Scott SM
(
2021
)
.
Clinical Impact of Rectal Hyposensitivity: A Cross-Sectional Study of 2,876 Patients With Refractory Functional Constipation
.
American Journal of Gastroenterology
.
vol.
116
,
758
-
768
.
Vollebregt PF, Burgell RE, Hooper RL, Knowles CH, Scott SM
(
2021
)
.
Clinical Impact of Rectal Hyposensitivity: A Cross-Sectional Study of 2,876 Patients With Refractory Functional Constipation
.
Am J Gastroenterol
vol.
116
,
(
4
)
758
-
768
.
Glasbey JC, Nepogodiev D, Simoes JFF, Omar OM, Venn ML, Evans JP, Futaba K, Knowles CH et al.
(
2021
)
.
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
.
Colorectal Disease
vol.
23
,
(
3
)
732
-
749
.
Rasijeff AMP, Garcia-Zermeno K, Carrington EV, Knowles C, Scott SM
(
2021
)
.
Systematic evaluation of cough-anorectal pressure responses in health and in fecal incontinence: A high-resolution anorectal manometry study
.
Neurogastroenterology and Motility
vol.
33
,
(
3
)
Knowles CH, de Wachter S, Engelberg S, Lehur P, Matzel KE, Zirpel L, Bertapelle MP, Chartier-Kastler E et al.
(
2021
)
.
The science behind programming algorithms for sacral neuromodulation
.
Colorectal Disease
vol.
23
,
(
3
)
592
-
602
.
Vollebregt PF, Wiklendt L, Ang D, Venn ML, Mekhael M, Christensen P, Dinning PG, Knowles CH et al.
(
2021
)
.
Altered anal slow-wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights
.
Colorectal Disease
vol.
23
,
(
2
)
444
-
450
.
Corsetti M, Brown S, Chiarioni G, Dimidi E, Dudding T, Emmanuel A, Fox M, Ford AC et al.
(
2021
)
.
Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment
.
Neurogastroenterology and Motility
Bravo L, Nepogodiev D, Glasbey JC, Li E, Simoes JFF, Kamarajah SK, Picciochi M, Abbott TEF et al.
(
2021
)
.
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: The COVIDSurg mortality score
.
British Journal of Surgery
vol.
19
,
(
4
)
Fomenko OY, Morozov SV, Scott SM, Knowles CH, Morozov DA, Shelygin YA, Maev IV, Nikityuk DB et al.
(
2021
)
.
Recommendations for the Protocol of functional examination of the anorectal zone and disorders classification: The International Anorectal Physiology Working Group consensus and Russian real-world practice
.
Terapevticheskii Arkhiv
vol.
92
,
(
12
)
105
-
119
.
Chaichanavichkij P, Vollebregt PF, Scott SM, Knowles CH
(
2020
)
.
Botulinum toxin type A for the treatment of dyssynergic defaecation in adults: a systematic review
.
Colorectal Disease
vol.
22
,
(
12
)
1832
-
1841
.
Leo CA, Leeuwenburgh M, Orlando A, Corr A, Scott SM, Murphy J, Knowles CH, Vaizey CJ et al.
(
2020
)
.
Initial experience with SphinKeeper™ intersphincteric implants for faecal incontinence in the UK: a two-centre retrospective clinical audit
.
Colorectal Disease
vol.
22
,
(
12
)
2161
-
2169
.
Lee MJ, Dimairo M, Edwards J, Hawkins DJ, Hind D, Knowles CH, Hooper R, Brown SR et al.
(
2020
)
.
Non-randomized studies should be considered for assessing surgical techniques in rectal prolapse: prospective cohort study
.
Colorectal Disease
vol.
22
,
(
12
)
2170
-
2180
.
Lehur PA, Sørensen M, Dudding TC, Knowles CH, de Wachter S, Engelberg S, Matzel KE
(
2020
)
.
Programming Algorithms for Sacral Neuromodulation: Clinical Practice and Evidence—Recommendations for Day-to-Day Practice
.
Neuromodulation
vol.
23
,
(
8
)
1121
-
1129
.
Glasbey JC, Bibi S, Pata F, Ozkan BB, Van Straten S, Hodson J, Chapman SJ, Blanco-Colino R et al.
(
2020
)
.
Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study
.
Colorectal Disease
vol.
22
,
(
12
)
2288
-
2297
.
Vollebregt PF, Wiklendt L, Dinning PG, Knowles CH, Scott SM
(
2020
)
.
Coexistent faecal incontinence and constipation: A cross-sectional study of 4027 adults undergoing specialist assessment
.
EClinicalMedicine
vol.
27
,
Toth R, Zamora M, Ottaway J, Gillbe T, Martin S, Benjaber M, Lamb G, Noone T et al.
(
2020
)
.
DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology
.
Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
.
vol.
2020-October
,
3433
-
3440
.
Glasbey JC, Nepogodiev D, Simoes J, Omar O, Li E, Venn ML, CovidSurg Collaborative
(
2020
)
.
Elective cancer surgery in COVID-19 free surgical pathways during the SARS-CoV-2 pandemic: An international, multi-centre, comparative cohort study
.
Journal of Clinical Oncology
vol.
38
,
El-Dhuwaib Y, Pandyan A, Knowles CH
(
2020
)
.
Epidemiological trends in surgery for rectal prolapse in England 2001–2012: an adult hospital population-based study
.
Colorectal Disease
vol.
22
,
(
10
)
1359
-
1366
.
Arulampalam T, Bhangu A, Brown SR, Clark SK, Din F, Harji D, Knowles CH, McNamara D et al.
(
2020
)
.
Legacy of COVID-19 – the opportunity to enhance surgical services for patients with colorectal disease
.
Colorectal Disease
vol.
22
,
(
10
)
1219
-
1228
.
Manara J, Sandhu H, Wee M, Odutola A, Wainwright T, Knowles C, Middleton R
(
2020
)
.
Prolonged operative time increases risk of blood loss and transfusion requirements in revision hip surgery
.
European Journal of Orthopaedic Surgery and Traumatology
vol.
30
,
(
7
)
1181
-
1186
.
Glasbey JC, Nepogodiev D, Omar O, Simoes JFF, Ademuyiwa A, Fiore M, Minaya-Bravo A, Shaw R et al.
(
2020
)
.
Delaying surgery for patients with a previous SARS-CoV-2 infection
.
British Journal of Surgery
Sideris M, McCaughey T, Hanrahan JG, Arroyo-Manzano D, Zamora J, Jha S, Knowles CH, Thakar R et al.
(
2020
)
.
Risk of obstetric anal sphincter injuries (OASIS) and anal incontinence: A meta-analysis
.
European Journal of Obstetrics and Gynecology and Reproductive Biology
vol.
252
,
303
-
312
.
Knowles CH
(
2020
)
.
Posterior Tibial Nerve Stimulation
.
Anorectal Physiology
,
Vollebregt PF, Hooper RL, Farmer AD, Miller J, Knowles CH, Scott SM
(
2020
)
.
Association between opioid usage and rectal dysfunction in constipation: A cross-sectional study of 2754 patients
.
Neurogastroenterology and Motility
vol.
32
,
(
7
)
Chapman SJ, Blanco-Colino R, Pérez-Ajates S, Bautista OA, Hodson J, Chapman SJ, Glasbey JC, Pata F et al.
(
2020
)
.
Safety of hospital discharge before return of bowel function after elective colorectal surgery
.
British Journal of Surgery
vol.
107
,
(
5
)
552
-
559
.
Vollebregt PF, Wiklendt L, Ang D, Dinning PG, Knowles CH, Scott SM
(
2020
)
.
Altered slow-wave pressure activity in low anterior resection syndrome: New mechanistic insight into pathophysiology?
.
NEUROGASTROENTEROLOGY AND MOTILITY
.
vol.
32
,
Vollebregt PF, Wiklendt L, Dinning PG, Knowles CH, Scott SM
(
2020
)
.
Coexistence of faecal incontinence with constipation: An underappreciated clinical problem in adults. A phenotyping study of 4027 patients
.
De Wachter S, Knowles CH, Elterman DS, Kennelly MJ, Lehur PA, Matzel KE, Engelberg S, Van Kerrebroeck PEV
(
2020
)
.
New Technologies and Applications in Sacral Neuromodulation: An Update
.
Advances in Therapy
vol.
37
,
(
2
)
637
-
643
.
Kemppinen A, Howell C, Allgar V, Dodd M, Gregson J, Knowles C, McLaughlin J, Pandya P et al.
(
2020
)
.
Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel® in the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults
.
Trials
vol.
21
,
(
1
)
Adegbola S, Sarafian M, Sahnan K, Pechlivanis A, Phillips R, Knowles C, Haddow J, Warusavitarne J et al.
(
2020
)
.
P345 Lack of anti-TNF drugs levels in fistula tissue: A reason for non-response in Crohn’s perianal fistula?
.
Journal of Crohn's and Colitis
vol.
14
,
(
Supplement_1
)
s330
-
s331
.
Chapman SJ, Clerc D, Blanco-Colino R, Otto A, Nepogodiev D, Pagano G, Schaeff V, Soares A et al.
(
2020
)
.
Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
.
British Journal of Surgery
vol.
107
,
(
2
)
e161
-
e169
.
Carrington EV, Heinrich H, Knowles CH, Fox M, Rao S, Altomare DF, Bharucha AE, Burgell R et al.
(
2020
)
.
The international anorectal physiology working group (IAPWG) recommendations: Standardized testing protocol and the London classification for disorders of anorectal function
.
Neurogastroenterology and Motility
vol.
32
,
(
1
)
Cibert-Goton V, Kung VWS, McGuire C, Hockley JRF, Tranter MM, Dogra H, Belai A, Blackshaw LA et al.
(
2019
)
.
Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?
.
Pain
vol.
161
,
(
4
)
773
-
786
.
Haddow JB, Musbahi O, MacDonald TT, Knowles CH
(
2019
)
.
Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn's disease-related perianal fistula
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Conference:
Digestive Disorders Federation 2015
(
London, UK
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from:
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Basic and clinical aspects of gastrointestinal pain
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Rovedatti L, Di Sabatino A, Kudo T, Sarra M, Rampton D, Knowles CH, Sengupta N, Monteleone G et al.
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P294 - Control of interleukin-17 production in inflammatory bowel disease
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Journal of Crohn's and Colitis
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New techniques in the tissue diagnosis of gastrointestinal neuromuscular diseases
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World J Gastroenterol
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The role of humoral autoimmunity in gastrointestinal neuromuscular diseases
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Prog Neurobiol
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Dig Dis Sci
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Karling P, Abrahamsson H, Dolk A, Hallbook O, Hellstrom PM, Knowles CH, Kjellstrom L, Lindberg G et al.
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Function and dysfunction of the colon and anorectum in adults: Working team report of the Swedish Motility Group (SMoG)
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SCAND J GASTROENTERO
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Knowles AM, Knowles CH, Scott SM, Lunniss P
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Effects of age and gender on three-dimensional endoanal ultrasonography measurements: development of normal ranges
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TECH COLOPROCTOL
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British Journal of Sports Medicine
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BRIT J SPORT MED
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Williams NS, Murphy J, Knowles C, Chan C, Ahmed S
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Letter in response to colorectal disease article on intersphincteric resection
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Surgical treatment of patients with constipation and fecal incontinence
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GASTROENTEROL CLIN N
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Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel
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COLORECTAL DIS
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Knowles CH, Veress B, Tornblom H, Wallace S, Paraskeva P, Darzi A, Martin JE, Nyberg B et al.
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Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy
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NEUROGASTROENT MOTIL
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Williams NS, Murphy J, Knowles CH
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Anterior Perineal PlanE for Ultra-low Anterior Resection of the Rectum (the APPEAR technique): a prospective clinical trial of a new procedure
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Ann Surg
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Knowles CH, Aziz Q
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Visceral hypersensitivity in non-erosive reflux disease
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Gut
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Docena GH, Fanning A, Rovedatti L, Di Sabatino A, Leakey NA, Knowles CH, Lee K, Shanahan F et al.
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Activation and modulation of the MAP kinase pathway in IBD
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Matthews PJ, Knowles CH, Chua YC, Delaney C, Hobson AR, Aziz Q
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Effects of the concentration and frequency of acid infusion on the development and maintenance of esophageal hyperalgesia in a human volunteer model
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Am J Physiol Gastrointest Liver Physiol
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Gooneratne ML, Facer P, Knowles CH, Chan CL, Lunniss PJ, Scott SM, Anand P, Williams NS
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Normalization of substance P levels in rectal mucosa of patients with faecal incontinence treated successfully by sacral nerve stimulation
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BRITISH JOURNAL OF SURGERY
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Knowles CH, De Giorgio R
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Observations on a vestigial organ: a potential surrogate for enteric neuromesenchymal disease
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NEUROGASTROENT MOTIL
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Irving PM, Macey MG, Feakins RM, Knowles CH, Frye JN, Liyanage SH, DORUDI S, Williams NS et al.
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Platelet-leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis
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Docena G, Fanning A, Rovedatti L, Di Sabatino A, Leakey N, Knowles C, Lee K, Shanahan F et al.
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OC1.04.3 ACTIVATION AND MODULATION OF THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN INFLAMMATORY BOWEL DISEASE
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Digestive and Liver Disease
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Digestive and Liver Disease
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Zarate N, Knowles CH, Newell M, Garvie NW, Gladman MA, Lunniss PJ, Scott SM
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The phagocytic capacity of neurones
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Does anastomotic technique influence anorectal function after sphincter-saving rectal cancer resection? A systematic review of evidence from randomized trials
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J AM COLL SURGEONS
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Donaldson J, Knowles CH, Clark SK, Renfrew I, Lobo MD
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Rectus sheath haematoma associated with low molecular weight heparin: a case series
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ANN ROY COLL SURG
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Tornblom H, Lang B, Clover L, Knowles CH, Vincent A, Lindberg G
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Autoantibodies in patients with gut motility disorders and enteric neuropathy
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SCAND J GASTROENTERO
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Combined abdominal and perineal approach for delayed restoration of bowel continuity after low anterior resection in females
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The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis
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Stabbing: data support public perception
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BMJ
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The Snug Seton: short and medium term results of slow fistulotomy for idiopathic anal fistulae
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Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series
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Deranged smooth muscle alpha-actin: A bio-marker of intestinal pseudo-obstruction. A controlled multinational case series and ontological study
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Anal sphincter morphology in patients with full-thickness rectal prolapse
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Anal sphincter morphology in patients with full-thickness rectal prolapse
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Diseases of the Colon and Rectum.
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Intraoperative culture in appendicitis: historical practice challenged
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Idiopathic Slow-Transit Constipation: An Almost Exclusively Female Disorder
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Diseases of the Colon & Rectum
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Evaluation of intraoperative bacterial cultures in 721 patients with acute appendicitis
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Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation
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Rectal heat thresholds: a novel test of the sensory afferent pathway
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A systematic analysis of polyglucosan bodies in the human gastrointestinal tract in health and disease
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Acta Neuropathol
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Gladman MA, Scott SM, Khela M, Newell M, Miller M, Knowles CH, Williams NS, Lunniss PJ
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Creation of a treatment protocol for nurse-led management of anal fissure
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Lunniss PJ, KNOWLES CH, Scott SM, Allison ME, Legg PE
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Mukherjee D, Khela MK, Castillo FD, Scott SM, Knowles CH, Yazaki E, Evans DF, Kadirkamanathan SS
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Estimation of bolus transport and clearance in an oesophageal model using multichannel intraluminal impedance (MII): Validation study with gamma scintigraphy (GS)
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GASTROENTEROLOGY
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A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility
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Scand J Gastroenterol
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Facer P, Knowles CH, Tam PKH, Ford AP, Dyer N, Baecker PA, Anand P
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Novel capsaicin (VR1) and purinergic (P2X(3)) receptors in Hirschsprung's intestine
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JOURNAL OF PEDIATRIC SURGERY
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Williams NS, KNOWLES CH, Anand P, Birch R, Smith JA, Yiangou Y, Facer P, Sangameswaran L et al.
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Increased acid-sensing ion channel ASIC-3 in inflamed human intestine
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KNOWLES CH, Sampietre SN, de Souza LJ, Machado MC, Monteiro Cunha JE, Leite KR, Assis RS, Jancar S
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Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis
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Chan CLH, Yiangou Y, Facer P, Dyer NHC, Knowles CH, Williams NS, Anand P
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Increased capsaicin receptor VR1-immunoreactivity in acute inflammatory bowel disease
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Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation
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Vanilloid receptor 1 immunoreactivity in inflamed human bowel
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CLH C, Scott SM, Knowles CH, Lunniss PJ
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Scintigraphic assessment of colonic transit in women with slow-transit constipation arising de novo and following pelvic surgery or childbirth
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Br J Surg
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Smooth muscle inclusion bodies in slow transit constipation
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ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease
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Knowles CH, Eccersley AJ, Scott SM, Walker SM, Reeves B, Lunniss PJ
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Linear discriminant analysis of symptoms in patients with chronic constipation: validation of a new scoring system (KESS)
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Idiopathic slow-transit constipation is not associated with mutations of the RET proto-oncogene or GDNF
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Simple radio-opaque marker studies versus scintigraphy in slow colonic transit — a comparison
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Wellmer A, Sharief MK, Knowles CH, Misra VP, Kopelman P, Ralph D, Anand P
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Quantitative sensory and autonomic testing in male diabetic patients with erectile dysfunction
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Knowles CH, Scott SM, Wellmer A, Misra VP, Pilot MA, Williams NS, Anand P
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Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation
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