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Research

Publications: Mr Wayne Huttly

Vale SH, Huttly WJ, Wald NJ ( 2021 ) . Antenatal screening for Down's syndrome: Revised nuchal translucency upper truncation limit due to improved precision of measurement . J Med Screen vol. 28 , ( 2 ) 88 - 92 .
Wald NJ, Bestwick JP, Lau KW, Huttly WJ, Ke W, Cheng R, Old RW ( 2019 ) . A simple method to allow for guanine-cytosine amplification error in prenatal DNA screening for trisomy 18 . Clinica Chimica Acta vol. 496 , 13 - 17 .
Wald NJ, Bestwick JP, Huttly WJ, Aldis J, Borrell A, Goodburn S, Mills I ( 2019 ) . Corrigendum to: Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies (Prenatal Diagnosis, (2018), 38, 13, (1079-1085), 10.1002/pd.5381) . Prenatal Diagnosis vol. 39 , ( 6 ) 489 - 491 .
WALD NJ, BESTWICK J, HUTTLY W, Aldis J, Borrell A, Goodburn S, Mills I ( 2018 ) . Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies . Prenatal Diagnosis
WALD NJ, LAU KW, BESTWICK J, Old R, HUTTLY W, CHENG R ( 2018 ) . Specifying a Gold-Standard for the validation of fetal fraction estimation in prenatal screening . Clinical Chemistry vol. 64 , ( 9 ) 1394 - 1399 .
BESTWICK JP, HUTTLY W, WALD N ( 2018 ) . Serum marker truncation limits in first trimester antenatal screening for trisomy 18 . Journal of Medical Screening
Wald NJ, Huttly WJ, Bestwick JP, Old R, Morris JK, Cheng R, Aquilina J, Peregrine E et al. ( 2018 ) . Response to Walker . Genet Med
WALD NJ, Huttly WJ, Bestwick JP, Old R, Morris JK, Cheng R, Aquilina J, Peregrine E et al. ( 2017 ) . Prenatal reflex DNA screening for trisomy 21, 18, and 13 . Genetics in Medicine
Bestwick JP, Huttly WJ, Wald NJ ( 2017 ) . Pregnancy-associated plasma protein-A truncation limits in antenatal screening for trisomy 18 . J Med Screen969141316688499 - 969141316688499 .
Huttly WJ, Bestwick JP, Wald NJ ( 2016 ) . Insulin dependent diabetes mellitus (IDDM) and first trimester markers in prenatal screening for Down syndrome . Prenatal Diagnosis vol. 36 , ( 2 ) 192 - 193 .
Wald NJ, Huttly WJ, Bestwick JP, Aquilina J, Peregrine E ( 2015 ) . Reflex antenatal DNA screening for Down syndrome . Prenatal Diagnosis vol. 35 , ( 11 ) 1154 - 1154 .
( 2015 ) . Corrigendum . J Med Screen vol. 22 , ( 1 ) 52 - 54 .
Bestwick JP, Huttly WJ, Wald NJ ( 2014 ) . The estimation of median nuchal translucency values between 10 and 14 weeks of pregnancy . J Med Screen vol. 21 , ( 2 ) 110 - 112 .
Huttly W, Bestwick J, Wald N ( 2014 ) . Effect of smoking status on inhibin-A in second-trimester prenatal screening for Down syndrome . Prenat Diagn vol. 34 , ( 4 ) 406 - 407 .
Bestwick JP, Huttly WJ, Morris JK, Wald NJ ( 2014 ) . Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women . PLoS One vol. 9 , ( 2 )
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Detection of trisomy 18 and trisomy 13 using first and second trimester Down's syndrome screening markers . J Med Screen vol. 20 , ( 2 ) 57 - 65 .
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Allowing for ethnic group in antenatal screening for Down's syndrome . J Med Screen vol. 20 , ( 1 ) 52 - 54 .
Wald NJ, Bestwick JP, Huttly WJ ( 2013 ) . Improvements in antenatal screening for Down's syndrome . J Med Screen vol. 20 , ( 1 ) 7 - 14 .
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Allowing for ethnic group in antenatal screening for Down's syndrome . JOURNAL OF MEDICAL SCREENING vol. 20 , ( 1 ) 52 - 54 .
Huttly WJ, Wald NJ ( 2012 ) . The estimation of gestational age of pregnancy for use in screening for Down syndrome using ultrasound measurements and embryo transfer date . Prenat Diagn vol. 32 , ( 10 ) 1008 - 1009 .
Wald NJ, Bestwick JP, Huttly WJ ( 2012 ) . Effect of interrupting prenatal Down syndrome screening due to a large nuchal translucency . Prenat Diagn vol. 32 , ( 7 ) 655 - 661 .
Bestwick JP, Huttly WJ, Wald NJ ( 2012 ) . Unconjugated estriol values between 14 and 22 weeks of gestation in relation to prenatal screening for Down syndrome . Prenatal Diagnosis vol. 32 , ( 7 )
Bestwick JP, Huttly WJ, Wald NJ ( 2012 ) . Unconjugated estriol values between 14 and 22 weeks of gestation in relation to prenatal screening for Down syndrome . Prenat Diagn vol. 32 , ( 3 ) 299 - 301 .
Wald NJ, Bestwick JP, George LM, Huttly WJ ( 2012 ) . Antenatal screening for Down syndrome using serum placental growth factor with the combined, quadruple, serum integrated and integrated tests . PLoS One vol. 7 , ( 10 )
Huttly WJ, Wald NJ ( 2011 ) . An audit of the detection of trisomy 18 in prenatal screening for Down syndrome using the Combined test . Prenat Diagn vol. 31 , ( 13 )
Filippi E, Staughton J, Peregrine E, Jones P, Huttly W, Peebles DM, Pandya P, David AL ( 2011 ) . Uterine artery Doppler and adverse pregnancy outcome in women with extreme levels of fetoplacental proteins used for Down syndrome screening . Ultrasound Obstet Gynecol vol. 37 , ( 5 ) 520 - 527 .
Filippi E, Staughton J, Peregrine E, Jones P, Huttly W, Peebles D, Pandya P, David A ( 2010 ) . Uterine artery Doppler and adverse pregnancy outcome in women with extreme levels of feto-placental proteins used for Down's syndrome screening . Ultrasound Obstet Gynecol
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Distribution of nuchal translucency in antenatal screening for Down's syndrome (vol 17, pg 8, 2010) . J MED SCREEN vol. 17 , ( 2 ) 106 - 106 .
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Distribution of nuchal translucency in antenatal screening for Down's syndrome . J Med Screen vol. 17 , ( 1 ) 8 - 12 .
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Evaluation of a proposed mixture model to specify the distributions of nuchal translucency measurements in antenatal screening for Down's syndrome . J Med Screen vol. 17 , ( 1 ) 13 - 18 .
Wald NJ, Huttly WJ, Murphy KW, Ali K, Bestwick JP, Rodeck CH ( 2009 ) . Antenatal screening for Down's syndrome using the Integrated test at two London hospitals . J Med Screen vol. 16 , ( 1 ) 7 - 10 .
Wald NJ, Huttly WJ, Bestwick JP ( 2008 ) . Inhibin-A concentrations between 14 and 22 weeks of gestation . Prenat Diagn vol. 28 , ( 4 ) 360 - 361 .
Bestwick JP, Huttly WJ, Wald NJ ( 2008 ) . First trimester Down's syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free beta human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency . J Med Screen vol. 15 , ( 4 ) 204 - 206 .
Weisz B, Pandya PP, David AL, Huttly W, Jones P, Rodeck CH ( 2007 ) . Ultrasound findings after screening for Down syndrome using the integrated test . Obstet Gynecol vol. 109 , ( 5 ) 1046 - 1052 .
Weisz B, Pandya P, Chitty L, Jones P, Huttly W, Rodeck C ( 2007 ) . Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice . BJOG vol. 114 , ( 4 ) 493 - 497 .
Huttly WJ, Morris JK, Bestwick JP, Wald NJ, Murphy K, Pandya PP ( 2006 ) . Three stage contingent screening for Down syndrome . Prenat Diagn vol. 26 , ( 12 )
Wald NJ, Barnes IM, Birger R, Huttly W ( 2006 ) . Effect on Down syndrome screening performance of adjusting for marker levels in a previous pregnancy (vol 26, pg 539, 2006) . PRENATAL DIAGNOSIS vol. 26 , ( 6 ) 589 - 589 .
Wald NJ, Barnes IM, Birger R, Huttly W ( 2006 ) . Effect on Down syndrome screening performance of adjusting for marker levels in a previous pregnancy . Prenat Diagn vol. 26 , ( 6 ) 539 - 544 .
Wald NJ, Bestwick JP, Huttly WJ, Morris JK, George LM ( 2006 ) . Validation plots in antenatal screening for Down's syndrome . J Med Screen vol. 13 , ( 4 ) 166 - 171 .
Wald NJ, Huttly WJ, Rudnicka AR ( 2004 ) . Recurrent false-positives in AFP screening for open neural tube defects . Prenat Diagn vol. 24 , ( 12 ) 1018 - 1019 .
Huttly W, Rudnicka A, Wald NJ ( 2004 ) . Second-trimester prenatal screening markers for Down syndrome in women with insulin-dependent diabetes mellitus . Prenat Diagn vol. 24 , ( 10 ) 804 - 807 .
RUDNICKA AR, Wald NJ, Huttly WJ ( 2004 ) . Parental screening for Downs syndrome: the problem of recurrent false-positives . Prenatal Diagnosis. vol. 24 , 389 - 392 .
Rudnicka AR, WALD NJ, Huttly W ( 2004 ) . Prenatal screening for Down syndrome: the problem of recurrent false-positives . Prenatal Diagnosis. vol. 24 , ( 5 ) 389 - 392 .
Alberman E, Huttly W, Hennessy E, McIntosh A ( 2003 ) . The use of record linkage for auditing the uptake and outcome of prenatal serum screening and prenatal diagnostic tests for Down syndrome . Prenat Diagn vol. 23 , ( 10 ) 801 - 806 .
Wald NJ, Huttly WJ, Hackshaw AK ( 2003 ) . Antenatal screening for Down's syndrome with the quadruple test . Lancet vol. 361 , ( 9360 ) 835 - 836 .
Wald NJ, Huttly W, Hackshaw AK, Christiansen M, Larsen SO, Nørgaard-Pedersen B, Howe D, Wellesley D ( 2002 ) . Antenatal screening policies for Down's syndrome [3] (multiple letters) . British Medical Journal vol. 325 , ( 7371 ) 1034 - 1035 .
Wald NJ, Huttly W, Hackshaw AK ( 2002 ) . Antenatal screening policies for Down's syndrome. Audit of Down's syndrome screening is not valid . BMJ vol. 325 , ( 7371 )
Rudnicka AR, Wald NJ, Huttly W, Hackshaw AK ( 2002 ) . Influence of maternal smoking on the birth prevalence of Down syndrome and on second trimester screening performance . Prenat Diagn vol. 22 , ( 10 ) 893 - 897 .