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Research

Publications: Dr Steven Harwood

Dreyer G, Kieswich J, Harwood S, Ahluwalia A, Yaqoob MM ( 2019 ) . Ergocalciferol improves endothelial vasodilatory and vasoconstrictor function in an in vivo model of mild uraemia . Bioscience Reports vol. 39 , ( 12 )
Pile T, Raftery M, Thuraisingham R, Kirwan CJ, Harwood S, Yaqoob MM ( 2019 ) . Treating Posttransplant Anemia With Erythropoietin Improves Quality of Life but Does Not Affect Progression of Chronic Kidney Disease . Exp Clin Transplant
Andrikopoulos P, Kieswich J, Pacheco S, Nadarajah L, Harwood SM, O’Riordan CE, Thiemermann C, Yaqoob MM ( 2019 ) . The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling . Journal of the American Society of Nephrology vol. 30 , ( 1 ) 33 - 49 .
Duraisingham SK, Kieswich JE, Harwood SM, Yaqoob MM ( 2018 ) . ACUTE WOUND HEALING IN A RODENT MODEL OF UREMIA .
Duraisingham SK, Kieswich JE, Harwood SM, Yaqoob MM ( 2018 ) . Acute Wound Healing in a Rodent Model of Uremia .
Kieswich J, Sayers SR, Silvestre MF, Harwood SM, Yaqoob MM, Caton PW ( 2016 ) . Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment . Diabetologia1 - 10 .
Chesser AMS, Harwood SM, Raftery MJ, Yaqoob MM ( 2016 ) . Myocardial bioenergetic abnormalities in experimental uremia . International Journal of Nephrology and Renovascular Disease vol. 9 , 129 - 137 .
Kieswich J, Silvestre M, Harwood SM, Yaqoob MM, Caton PW ( 2016 ) . Chronic eNAMPT administration induces a diabetic phenotype in mice . DIABETIC MEDICINE vol. 33 , 45 - 46 .
Kieswich J, Silvestre M, Harwood S, Yaqoob M, Caton P ( 2015 ) . eNAMPT-monomer plays a critical role in pathophysiology of experimental diabetes and represents a novel target for treatment of type 2 diabetes . Endocrine Abstracts
Andrikopoulos P, Kieswich J, Harwood SM, Baba A, Matsuda T, Barbeau O, Jones K, Eccles SA et al. ( 2015 ) . Endothelial angiogenesis and barrier function in response to thrombin require Ca<sup>2+</sup> influx through the Na<sup>+</sup>/Ca<sup>2+</sup>exchanger . Journal of Biological Chemistry vol. 290 , ( 30 ) 18412 - 18428 .
Kieswich J, Silvestre MP, Harwood SM, Yaqoob MM, Caton PW ( 2015 ) . Immuno-neutralisation of extracellular nicotinamide phosphoribosyltransferase as a therapeutic strategy for treatment of Type 2 diabetes . DIABETIC MEDICINE vol. 32 , 47 - 47 .
White WE, Yaqoob MM, Harwood SM ( 2015 ) . Aging and uremia: Is there cellular and molecular crossover? . World J Nephrol vol. 4 , ( 1 ) 19 - 30 .
Gallagher SM, Jones DA, Kapur A, Wragg A, Harwood SM, Mathur R, Archbold RA, Uppal R et al. ( 2015 ) . Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery . Kidney International vol. 87 , ( 2 ) 473 - 481 .
Gallagher SM, Jones DA, Kapur A, Wragg A, Harwood SM, Mathur R, Archbold RA, Uppal R et al. ( 2015 ) . Remote ischemic preconditioning has a neutral effect on the incidence of kidney injury after coronary artery bypass graft surgery . Kidney Int vol. 87 , ( 2 ) 473 - 481 .
Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP et al. ( 2014 ) . Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia . Proc Natl Acad Sci U S A vol. 111 , ( 10 ) 3817 - 3822 .
Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM ( 2014 ) . Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial . PLoS One vol. 9 , ( 7 )
McCafferty K, Byrne CJ, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM ( 2012 ) . Response to letter regarding article, "ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction" . Circulation vol. 126 , ( 13 )
Shah S, Harwood SM, Döhler B, Opelz G, Yaqoob MM ( 2012 ) . Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome . Transplantation vol. 94 , ( 5 ) 486 - 491 .
Byrne CJ, McCafferty K, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM ( 2012 ) . Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction . Circulation vol. 125 , ( 10 ) 1256 - 1265 .
Nandra KK, Patel NS, Harwood S, Collino M, Rogazzo M, Yaqoob M, Thiemermann C ( 2012 ) . THREE DAY PRE-TREATMENT WITH ERYTHROPOIETIN ATTENUATES THE ORGAN INJURY AND DYSFUNCTION INDUCED BY HEMORRHAGIC SHOCK IN THE RAT BY A MECHANISM INDEPENDENT OF ENDOTHELIAL PROGENITOR CELL MOBILISATION . SHOCK . vol. 37 , 96 - 97 .
Pile T, Kieswich J, Harwood S, Yaqoob MM ( 2011 ) . A possible explanation for anemia in patients treated with mycophenolic acid . Transplantation vol. 92 , ( 12 ) 1316 - 1321 .
Qureshi AC, Rampat R, Harwood S, Roughton M, Yaqoob MM, Kapur A ( 2011 ) . Urine NGAL and IL-18 Identify CI-AKI Early in Patients with DM and CKD Undergoing Coronary Angiography/PCI . JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY . vol. 58 , B26 - B27 .
Qureshi A, Rampat R, Harwood SM, Roughton M, Yaqoob MM, Kapur A ( 2011 ) . A combination of urine NGAL and IL-18 identifies contrast induced nephropathy early in patients with diabetes and CKD undergoing coronary angiography and PCI . EUROPEAN HEART JOURNAL vol. 32 , 92 - 92 .
Qureshi AC, Rampat R, Harwood SM, Roughton M, Yaqoob MM, Kapur A ( 2011 ) . SERUM NGAL IDENTIFIES CONTRAST NEPHROPATHY EARLY IN PATIENTS WITH DIABETES MELLITUS AND CHRONIC KIDNEY DISEASE UNDERGOING CORONARY ANGIOGRAPHY AND ANGIOPLASTY . HEART . vol. 97 , A17 - A18 .
Kumar S, Allen DA, Kieswich JE, Patel NSA, Harwood S, Mazzon E, Cuzzocrea S, Raftery MJ et al. ( 2009 ) . Dexamethasone ameliorates renal ischemia-reperfusion injury . J Am Soc Nephrol vol. 20 , ( 11 ) 2412 - 2425 .
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM ( 2007 ) . High glucose initiates calpain-induced necrosis before apoptosis in LLC-PK1 cells . Kidney Int vol. 71 , ( 7 ) 655 - 663 .
Allen DA, Yaqoob MM, Harwood SM ( 2005 ) . Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications . J Nutr Biochem vol. 16 , ( 12 ) 705 - 713 .
Harwood SM, Yaqoob MM, Allen DA ( 2005 ) . Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis . Ann Clin Biochem vol. 42 , ( Pt 6 ) 415 - 431 .
Harwood S, Yaqoob MM ( 2005 ) . Ouabain-induced cell signaling . Front Biosci vol. 10 , 2011 - 2017 .
Ashman N, Harwood SM, Kieswich J, Allen DA, Roberts NB, Mendes-Ribeiro AC, Yaqoob MM ( 2005 ) . Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells . KIDNEY INT vol. 67 , ( 5 ) 1878 - 1889 .
THIEMERMANN C, Yaqoob MM, Raftery M, Harwood S, Allen D, Mota-Philipe H, Brown P, Sharples EJ et al. ( 2004 ) . Erythropoietin Protects the Kidney against the Injury and Dysfunction Caused by Ischemia-Reperfusion . Journal American Society of Nephrology vol. 15 , 2115 - 2124 .
Steddon SJ, Harwood SM, Allen DA, Burrin JM, Cunningham J, Yaqoob MM ( 2003 ) . Calpain activation is concurrent with caspase-3 suppression in IGF-I treated human osteoblastic cells . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 467A - 467A .
Allen DA, Harwood SM, Raftery MJ, Yaqoob MM ( 2003 ) . Calpain: A mediator of high glucose-induced necrosis and apoptosis in proximal tubular epithelial cells . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 387A - 387A .
Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Allen DA, Harwood SM et al. ( 2003 ) . Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion injury by the inhibition of the caspase cascade and apoptosis . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 273A - 273A .
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM ( 2003 ) . Low ouabain concentrations stimulate calpain activity in multiple cell lines . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 339A - 339A .
Ashman N, Harwood SM, Kieskiewicz J, Ribeiro CM, Raftery MJ, Yaqoob MM ( 2003 ) . Recombinant human albumin (rHSA) stimulates cell growth, L-arginine transport and metabolism to polyamines in human proximal tubular cells independent of PI-3 kinase inhibition . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY . vol. 14 , 341A - 341A .
Harwood SM, Allen DA, Raftery MJ, Yaqoob MM ( 2003 ) . Calpain is a mediator of myocardial injury in experimental uremia: is it activated by endogenous ouabain? . Kidney Int Suppl ( 84 ) S177 - S180 .
Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM ( 2003 ) . High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases . FASEB J vol. 17 , ( 8 ) 908 - 910 .
Harwood SM, Allen DA, Chesser AMS, New DI, Raftery MJ, Yaqoob MM ( 2003 ) . Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury? . Kidney Int vol. 63 , ( 3 ) 866 - 877 .
Allen DA, Harwood SM, Varagunam M, Raftery MJ, Yaqoob MM ( 2003 ) . High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases . FASEB J vol. 17 , ( 3 ) 908 - + .
Harwood S, Mullen AM, McMahon AC, Dawnay A ( 2001 ) . Plasma OLC is elevated in mild experimental uremia but is not associated with hypertension . AM J HYPERTENS vol. 14 , ( 11 ) 1112 - 1115 .
THIEMERMANN C, Miller NE, McDonald MC, Cockerill GW, Mota-Filipe H, Cuzzocrea S ( 2001 ) . High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock . FASEB Journal . vol. 15 , 1941 - 1952 .
THIEMERMANN C, Yaqoob MM, McDonald MC, Chatterjee PK, Harwood S, Plevin R, Mota-Filipe H, Paul A et al. ( 2001 ) . Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock . FASEB Journal vol. 15 , ( 1 ) 171 - 186 .
Harwood S, Alfazema L, Perrett D, Dawnay A ( 2000 ) . Analysis of human ouabainlike compound by micellar electrokinetic chromatography . HYPERTENSION RESEARCH . vol. 23 , S29 - S32 .
Hinson JP, Harwood S, Dawnay AB ( 1998 ) . Release of ouabain-like compound (OLC) from the intact perfused rat adrenal gland . Endocr Res vol. 24 , ( 3-4 ) 721 - 724 .
Lipkin GW, Thuraisingham R, Dawnay AB, Harwood SM, Raine AE ( 1997 ) . Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients . Transplantation vol. 64 , ( 7 ) 1007 - 1017 .
Lipkin GW, Dawnay ABS, Harwood SM, Cattell WR, Raine AEG ( 1997 ) . Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure . KIDNEY INTERNATIONAL vol. 52 , ( 3 ) 792 - 801 .
Harwood S, Little JA, Gallacher G, Perrett D, Edwards R, Dawnay A ( 1997 ) . Development of enzyme immunoassay for endogenous ouabain-like compound in human plasma . CLINICAL CHEMISTRY vol. 43 , ( 5 ) 715 - 722 .
LAMB EJ, WORRALL J, BUHLER R, HARWOOD S, CATTELL WR, DAWNAY AB ( 1995 ) . EFFECT OF DIABETES AND PERITONITIS ON THE PERITONEAL EQUILIBRATION TEST . KIDNEY INTERNATIONAL vol. 47 , ( 6 ) 1760 - 1767 .
LIPKIN GW, DAVIES S, HARWOOD SM, TOMSON CRV, DAWNAY ABS, RAINE AEG ( 1994 ) . CHRONIC NEUTRAL ENDOPEPTIDASE (NEP) INHIBITION ACCELERATES THE PROGRESSION OF EXPERIMENTAL CHRONIC-RENAL-FAILURE (CRF) . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 5 , ( 3 ) 949 - 949 .
DAWNAY A, WORRALL J, HARWOOD S, RAINE A ( 1994 ) . EFFECT OF DIABETES AND HYPERGLYCEMIA ON SOLUTE TRANSPORT AND ULTRAFILTRATION IN CAPD . JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY vol. 5 , ( 3 ) 513 - 513 .
LIPKIN GW, DAWNAY ABS, HARWOOD SM, KENDALL RG, CATTELL WR, RAINE AEG ( 1992 ) . RENAL HEMODYNAMIC, HORMONAL AND EXCRETORY EFFECTS OF LOW-DOSE ATRIAL-NATRIURETIC-FACTOR INFUSION IN RENAL-TRANSPLANT RECIPIENTS . CLINICAL SCIENCE vol. 82 , ( 2 ) 119 - 126 .