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Research

Publications: Prof David Griffiths

Awais RO, Duncanson P, Mills B, Luckett JC, Griffiths DV, Hill P, Williams P, Perkins AC ( 2014 ) . Tc-99m and In-111 labelled benzyl pyrimidine derivatives for targeting SNAP or CLIP protein sites on a genetically modified Gram positive bacterium . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 41 , S431 - S431 .
Mills B, Luckett J, Awais R, Duncanson P, Griffiths D, Perkins A, Williams P, Hill P ( 2014 ) . Validation and applications for SNAP-tag imaging of bacterial infection . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 41 , S639 - S639 .
Vaughan Griffiths D, Benoit DM, Cheong YK, Duncanson P, Han X ( 2014 ) . Novel ylidic phosphoryl compounds from halogenated furan-2,5-diones with trivalent phosphorus esters: Application of this approach to new trisphosphonates containing a geminal bisphosphonate unit . Phosphorus, Sulfur and Silicon and the Related Elements vol. 189 , 1013 - 1027 .
Awais R, Mills B, Luckett J, Williams P, Hill P, Perkins A, Duncanson P, Griffiths V ( 2014 ) . 99mTc-labelling of surface localised SNAP-tag sites on a Gram positive bacterium . Nuclear Medicine and Biology vol. 41 , ( 7 )
Griffiths DV, Benoit DM, Cheong Y-K, Duncanson P, Han X ( 2014 ) . Novel Ylidic Phosphoryl Compounds from Halogenated Furan-2,5-Diones with Trivalent Phosphorus Esters: Application of this Approach to New Trisphosphonates Containing a Geminal Bisphosphonate Unit . Phosphorus, Sulfur and Silicon and the Related Elements
Awais RO, Mills B, Luckett JCA, Duncanson P, Griffiths V, Williams P, Hill P, Perkins AC ( 2013 ) . Radiosynthesis of 99mTc-HYNIC-NH-BG: A new Tc-99m radiotracer to visualise specific cells in vivo via SNAP-tag . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 40 , S129 - S129 .
Mills B, Steele V, Luckett JCA, Awais RO, Duncanson P, Griffiths V, Cockayne A, Xu M et al. ( 2013 ) . Surface displayed SNAP-tag as a novel tool for study of Grampositive bacterial infections . EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING . vol. 40 , S178 - S178 .
Duncanson P, Cheong YK, Motevalli M, Griffiths DV ( 2012 ) . A novel approach to isoindolo[2,1-a]indol-6-ones . Org Biomol Chem vol. 10 , ( 21 ) 4266 - 4279 .
GRIFFITHS D, Cheong Y-K, Duncanson P, Motevalli M ( 2011 ) . Studies of the reactions of tripodal pyridine-containing ligands with Re(CO)5Br leading to rheniumtricarbonyl complexes with potential biomedical applications . Dalton Transactions vol. 40 , ( 39 ) 10215 - 10228 .
Cheong Y-K, Duncanson P, Griffiths DV, Motevalli M ( 2010 ) . The impact of ligand structure on the rheniumtricarbonyl complexes from tripodal pyridine-containing chelators . Nuclear Medicine and Biology . Conference: International symposium on Technetium and Other Radiometals in Chemistry and Medicine ( Bressanone, Italy ) from: 08/09/2010 to: 11/09/2010 , vol. 37 , 677 - 678 .
Cheong Y-K, Duncanson P, Griffiths DV ( 2010 ) . Isoindolo[2,1a]indol-6-one formation via the reaction of a phthaloylamino-substituted benzoylphosphonates with trialkyl phosphites involving phosphonate group migration and β-ketophosphonate formation . Book of Abstracts . Conference: 18th International Conference on Phosphorus Chemistry ( Wroclaw, Poland ) from: 11/07/2010 to: 15/07/2010 , 164 - 164 .
Cheong Y-K, Duncanson P, Griffiths DV, Awais RO ( 2010 ) . Novel products from the reactions of nitro-substituted benzoylphosphonates with trialkyl phosphites including the formation of reactive ylidic-phosphates . Book of Abstracts . Conference: 18th International Conference on Phosphorus Chemistry ( Wroclaw, Poland ) from: 11/07/2010 to: 15/07/2010 , 158 - 158 .
GRIFFITHS D, Al-Jeboori MJ, Arnold PJ, Cheong Y-K, Duncanson P, Motevalli M ( 2010 ) . Studies of rheniumtricarbonyl complexes of tripodal pyridyl-based ligands . Inorganica Chimica Acta vol. 363 , 1186 - 1194 .
Cheong Y-K, Duncanson P, Griffiths DV, Motevalli M ( 2010 ) . The impact of ligand structure on the rheniumtricarbonyl complexes from tripodal pyridine-containing chelators . Technetium and Other Radiometals in Chemistry and Medicine . Editors: Mazzi, U, Eckelman, WC , Conference: International symposium on Technetium and Other Radiometals in Chemistry and Medicine ( Bressanone, Italy ) from: 08/09/2010 to: 11/09/2010 , 37 - 40 .
Griffiths DV, Cheong Y-K, Duncanson P, Taylor HV ( 2009 ) . Novel products from the reactions of aroyl chlorides with trialkyl phosphites . Book of Abstracts . Conference: IIIrd Aminophosphorus and Phosphapeptide Meeting ( Vitoria-Gasteiz, Spain ) from: 17/09/2009 to: 18/09/2009 , 10 - 10 .
Cheong YK, Duncanson P, Griffiths DV ( 2008 ) . Cyclisation reactions of 2-substituted benzoylphosphonates with trialkyl phosphites via nucleophilic attack on a carbonyl-containing ortho substituent . TETRAHEDRON vol. 64 , ( 10 ) 2329 - 2338 .
Griffiths DV, Al-Jeboori MJ, Cheong Y-K, Duncanson P, Harris JE, Salt MC, Taylor HV ( 2008 ) . Electron-rich heteroaroylphosphonates and their reaction with trimethyl phosphite . Org Biomol Chem vol. 6 , ( 3 ) 577 - 585 .
Griffiths DV, Groombridge HJ, Salt MC ( 2008 ) . Investigations into the oxidative stability of hydroxymethyl- and bis(hydroxymethyl)-phosphines . PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS . vol. 183 , 473 - 478 .
Cheong Y-K, Duncanson P, Han X ( 2008 ) . Synthesis and reactions of phosphorylated maleimides . Conference: 15th International conferences on Chemistry of Phosphorus compounds ( St Petersburg, Russia ) from: 25/05/2008 to: 30/05/2008 , 128 - 128 .
Cheong Y-K, Duncanson P ( 2008 ) . The reaction of trivalent phosphorus compounds with halogenated pyrrole- and furan-2,5-diones . Conference: 15th International conferences on Chemistry of Phosphorus compounds ( St Petersburg, Russia ) from: 25/05/2008 to: 30/05/2010 , 124 - 124 .
GRIFFITHS DV, Groombridge HJ, Salt MC ( 2006 ) . Investigations into the Inherent Oxidative Stability of the Hydroxymethylphosphine Centre in Chelates for 99mTc-Based Radiopharmaceuticals . Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . Conference: 7th International Symposium on Technetium , Rhenium and Other Metals in Chemistry and Nuclear Medicine ( Bresannone, Italy ) from: 05/09/2006 to: 09/09/2006 , vol. 7 , 163 - 164 .
GRIFFITHS DV, Groombridge HJ, Motevalli M, Salt MC ( 2006 ) . Nucleophilic Addition to Vinyl- and Divinyl-Phosphine Sulfides as a Convenient Approach for the Synthesis of Phosphine-Containing Chelates for Rhenium and Technetium . Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . Editors: Mazzi, U , Conference: 7th International Symposium on Technetium , Rhenium and Other Metals in Chemistry and Nuclear Medicine ( Bresannone, Italy ) from: 05/09/2006 to: 09/09/2006 , vol. 7 , 105 - 106 .
GRIFFITHS DV, Duncanson P, Bhalla R, Iveson PB, Powell NA, O'Shea D, Wadsworth H ( 2006 ) . Synthesis of Bifunctional Tetraamine Chelates . Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . Conference: 7th International Symposium on Technetium , Rhenium and Other Metals in Chemistry and Nuclear Medicine ( Bresannone, Italy ) from: 05/09/2006 to: 09/09/2006 , vol. 7 , 161 - 162 .
GRIFFITHS DV, Duncanson P, Arnold PJ, Motevalli M, Bhalla R ( 2006 ) . Tris-Pyridyl Chelates for the Preparation of Lipophilic Cationic Complexes with Potential Radiopharmaceutical Applications . Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine . Conference: 7th International Symposium on Technetium , Rhenium and Other Metals in Chemistry and Nuclear Medicine ( Bresannone, Italy ) from: 05/09/2006 to: 09/09/2006 , vol. 7 , 165 - 166 .
Phillips MJ, Duncanson P, Darr JA, Wilson K, GRIFFITHS DV, Rehman I ( 2005 ) . Surface modification of bioceramics by grafting of tailored allyl phosphonic acid . Advances in Applied Ceramics vol. 104 , ( 5 ) 261 - 267 .
Griffiths DV, Groornbridge HJ, Mahoney PM, Swetnam SP, Walton G, York DC ( 2005 ) . Nucleophilic addition to dimethylvinylphosphine sulfide as a convenient route to polydentate ligands containing the 2-dimethylphosphinoethyl unit . TETRAHEDRON vol. 61 , ( 19 ) 4595 - 4600 .
GRIFFITHS DV, Cheong Y-K, Imirniyaz T, Duncanson P, Salt MJ ( 2004 ) . Cyclisation reaction of aroylphosphonates with trialkyl phosphites via anionic intermediates . Conference: ICPC2004, Birmingham International Conference Centre, July 2004.
GRIFFITHS DV, Duncanson P ( 2004 ) . Novel ylides from the reaction of halogeno-substituted furan-2,5-diones with trivalent phosphorus compounds . Conference: ICPC2004, Birmingham International Conference Centre, July 2004.
GRIFFITHS DV, Groombridge HJ ( 2004 ) . Nucleophilic addition to dimethylvinylphosphine sulfide as a convenient route to polydentate ligands containing the 2-dimethylphosphinoethyl unit . Conference: ICPC2004, Birmingham International Conference Centre, July 2004
GRIFFITHS DV, Taylor HV, Salt M ( 2004 ) . The reaction of heteroaroylphosphonates with trialkyl phosphites . Conference: ICPC2004, Birmingham International Conference Centre, July 2004
Arnold PJ, Davies SC, Durrant MC, Griffiths DV, Hughes DL, Sharpe PC ( 2003 ) . Copper(II) nitrite complexes of tripodal ligands derived from 1,1,1-tris(2-pyridyl)methylamine . INORG CHIM ACTA vol. 348 , 143 - 149 .
Griffiths DV, Duncanson P ( 2002 ) . The reactions of trialkylsilyl-containing phosphites with electrophilic organic compounds . PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS . vol. 177 , 2213 - 2214 .
Scheuermann JEW, Ilyashenko G, Griffiths DV, WATKINSON M ( 2002 ) . Solvent-mediated selective single and double ring-opening of N-tosyl-activated aziridines using benzylamine . Tetrahedron Asymmetry vol. 13 , ( 3 ) 269 - 272 .
GRIFFITHS DV, Mahoney PM, Higley B, Caesar JC, Burke JF, Tonkinson DJ ( 2002 ) . Synthesis and Biodistribution Studies of the 99mTechnetium Oxo-Complexes of a Series of Substituted Bis(aminoethanethiol) Ligands incorporating N-Alkylated-piperidin-4-yl Ring Systems . Editors: Nicolini, M, Mazzi, U , 535 - 537 .
Scheuermann JEW, Ronketti F, Motevalli M, Griffiths DV, Watkinson M ( 2002 ) . The synthesis of C-2-symmetric 1,4,7-triazacyclononane ligands derived from chiral aziridines . NEW J CHEM vol. 26 , ( 8 ) 1054 - 1059 .
Gibson AM, Mendizabal M, Pither R, Pullan SE, Griffiths V, Duncanson P ( 2001 ) . Radiolabelled bisphosphonates and method . no. PCT/EP00/07490 ,
Arnold PJ, Davies SC, Dilworth JR, Durrant MC, Griffiths DV, Hughes DL, Richards RL, Sharpe PC ( 2001 ) . Copper complexes of the functionalised tripodal ligand tris(2-pyridyl)methylamine and its derivatives . J CHEM SOC DALTON ( 5 ) 736 - 746 .
Gooding SR, Winn PJ, Maurer RI, Ferenczy GG, Miller JR, Harris JE, Griffiths DV, Reynolds CA ( 2000 ) . Fully Polarizable QM/MM Calculations: An Application to the Nonbonded Iodine-Oxygen Interaction in Dimethyl-2-Iodobenzoylphosphonate . Journal of Computational Chemistry vol. 21 , ( 6 ) 478 - 482 .
Dilworth JR, Zheng Y, Griffiths DV ( 1999 ) . Binuclear complexes with ligands based on the 2,6-bis(diphenylphosphinomethyl)benzene framework. Syntheses and crystal structures of [Ir<inf>2</inf>Cl<inf>2</inf>(μ-CO){2,6-(Ph<inf>2</inf>PH<inf>2</inf>) <inf>2</inf>C<inf>6</inf>H<inf>3</inf>S}<inf>2</inf>]·2CH <inf>2</inf>Cl<inf>2</inf>, [Ni<inf>2</inf>{2,6-(Ph<inf>2</inf>PCH<inf>2</inf>)<inf>2</inf>C <inf>6</inf>H<inf>4</inf>S} .. . Journal of the Chemical Society - Dalton Transactions ( 11 ) 1877 - 1881 .
Griffiths DV, Caesar JC, Hughes JM, Mahoney PM, Swetnam SP, Walton G, York DC ( 1999 ) . Phosphine-Containing Ligands and the Search for a Tc-99m Based Myocardial Imaging Agent . Phosphorus Sulfur and Silicon and the Related Elements . vol. 144 , 485 - 488 .
Ahmed LS, Clegg W, Davies DA, Dilworth JR, Elsegood MRJ, Griffiths DV, Horsburgh L, Miller JR et al. ( 1998 ) . The preparation and coordination chemistry of substituted benzenethiols. Triphenylphosphine gold(I) complexes of sterically demanding and nondemanding arenethiols. The absence of gold(I)-gold(I) interactions . Polyhedron vol. 18 , ( 3-4 ) 593 - 600 .
Davies HO, Dilworth JR, Griffiths DV, Miller JR, Zheng Y ( 1998 ) . The synthesis and crystal structures of the amide NS<inf>3</inf> macrocycle L<inf>1</inf>, and the silver complexes [Ag(L<inf>1</inf>)] <inf>n</inf>[CF<inf>3</inf>so<inf>3</inf>]<inf>n</inf> and of [Ag(L<inf>2</inf>)] <inf>2</inf>[CF<inf>3</inf>so<inf>3</inf>]<inf>2</inf> (see abstract) . Polyhedron vol. 18 , ( 3-4 ) 459 - 467 .