Skip to main content
Research

Publications: Dr Richard Grose

Carter E, Yoneten K, Gavara N, Tyler E, Gauthier V, Murray E, Cameron A, Pearce O et al. ( 2022 ) . Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function .
Roozitalab R, Allen M, Grose RP ( 2022 ) . A 3d In Vitro Model To Unravel Myoepithelial-Macrophage Interactions In Breast Cancer Progression . TISSUE ENGINEERING PART A . vol. 28 , 113 - 113 .
Yu Z, Zhang J, Zhang Q, Wei S, Shi R, Zhao R, An L, Grose R et al. ( 2022 ) . Single-cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer . Cell Proliferation vol. 55 , ( 6 )
Jomrich G, Kollmann D, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A, Preusser M, Fassnacht C et al. ( 2022 ) . Expression of programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand (PD-L1) in adenocarcinomas of the gastroesophageal junction change significantly after neoadjuvant treatment . European Journal of Surgical Oncology vol. 48 , ( 2 ) 383 - 390 .
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al. ( 2022 ) . Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion . Cell Reports vol. 38 , ( 4 )
Zardab M, Stasinos K, Grose RP, Kocher HM ( 2022 ) . The Obscure Potential of AHNAK2 . Cancers (Basel) vol. 14 , ( 3 )
Mahmood HTNA, Tomas Bort E, Walker AJ, Grose RP, Chioni AM ( 2022 ) . FGF signalling facilitates cervical cancer progression . The Federation of European Biochemical Societies (FEBS) Journal
Coetzee AS, Carter EP, Rodríguez-Fernández L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C et al. ( 2022 ) . Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1 . Oncogene
Jomrich G, Kollmann D, Wilfing L, Radosavljevic S, Ramazanova D, Ristl R, Grose RP, Ilhan-Mutlu A et al. ( 2021 ) . Programmed death ligand 2 expression plays a limited role in adenocarcinomas of the gastroesophageal junction after preoperative chemotherapy . European Surgery - Acta Chirurgica Austriaca vol. 53 , ( 6 ) 287 - 293 .
Chioni AM, Grose RP ( 2021 ) . Biological significance and targeting of the fgfr axis in cancer . Cancers vol. 13 , ( 22 )
Carter EP, Roozitalab R, Gibson SV, Grose RP ( 2021 ) . Tumour microenvironment 3D-modelling: simplicity to complexity and back again . Trends in Cancer vol. 7 , ( 11 ) 1033 - 1046 .
Joseph MD, Bort ET, Grose RP, McCormick PJ, Simoncelli S ( 2021 ) . Quantitative super‐resolution imaging for the analysis of GPCR oligomerization . Biomolecules vol. 11 , ( 10 )
Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM et al. ( 2021 ) . Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption . Current Biology vol. 31 , ( 7 ) 1403 - 1416.e7 .
Carter EP, Coetzee AS, Bort ET, Wang Q, Kocher HM, Grose RP ( 2021 ) . Dissecting fgf signalling to target cellular crosstalk in pancreatic cancer . Cells vol. 10 , ( 4 )
Senga SS, Grose RP ( 2021 ) . Hallmarks of cancer—the new testament . Open Biology vol. 11 , ( 1 )
Coetzee A, Grose R, Kocher H ( 2021 ) . Pancreatic Cancer Organotypic Models . vol. 430 , 183 - 198 .
Coetzee AS, Carter EP, Milton CI, Heward JA, Uluyur F, Miao J, Mardakheh FK, Wang Y et al. ( 2020 ) . Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer . Pancreatology vol. 20 , ( 8 ) e19 - e19 .
Adams S, Csere J, D’angelo G, Carter E, Arnandis T, Dodel M, Kocher H, Grose R et al. ( 2020 ) . Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption .
Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R et al. ( 2020 ) . Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway . EMBO Molecular Medicine vol. 12 , ( 2 )
Coetzee A, Carter E, Heward J, Mardakheh F, Grose R, Kocher H ( 2019 ) . Abstract 5170: Targeting FGFR signaling to disrupt cellular cross-talk in pancreatic cancer . Cancer Research . vol. 79 , 5170 - 5170 .
Clayton NS, Grose RP ( 2018 ) . Emerging Roles of Fibroblast Growth Factor 10 in Cancer . Front Genet vol. 9 , 499 - 499 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
Clayton NS, Wilson AS, Laurent EP, Grose RP, Carter EP ( 2017 ) . Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment . Dev Dyn vol. 246 , ( 7 ) 493 - 501 .
Carter EP, Gopsill JA, Gomm JJ, Jones JL, Grose RP ( 2017 ) . A 3D in vitro model of the human breast duct: A method to unravel myoepithelial-luminal interactions in the progression of breast cancer . Breast Cancer Research vol. 19 , ( 1 )
Chioni A-M, Bajwa RT, Grose R ( 2016 ) . 3D Organotypic Culture Model to Study Components of ERK Signaling . Methods Mol Biol vol. 1487 , 255 - 267 .
Carter E, Gomm JJ, Jones LJ, Grose RP ( 2016 ) . A 3D in vitro model of the human breast duct: unravelling myoepithelial-luminal interactions in breast cancer . Breast Cancer Research and Treatment . Conference: UK Breast Cancer Research Symposium 2016 vol. 159 , 187 - 188 .
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al. ( 2016 ) . Developing drug combinations to co-target pancreatic cancer and its supporting stroma . Pancreatology vol. 16 , ( 3 )
Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P et al. ( 2016 ) . Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma . Journal of Pathology vol. 239 , ( 3 ) 286 - 296 .
Tanner Y, Grose RP ( 2016 ) . Dysregulated FGF signalling in neoplastic disorders . Seminars in Cell and Developmental Biology vol. 53 , Article C , 126 - 135 .
Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R et al. ( 2015 ) . Adaptive upregulation of EGFR limits attenuation of tumor growth by neutralizing IL6 antibodies, with implications for combined therapy in ovarian cancer . Cancer Research vol. 75 , ( 7 ) 1255 - 1264 .
Carter EP, Fearon AE, Grose RP ( 2015 ) . Careless talk costs lives: Fibroblast growth factor receptor signalling and the consequences of pathway malfunction . Trends in Cell Biology vol. 25 , ( 4 ) 221 - 233 .
Fearon AE, Chioni AM, Grose RP ( 2015 ) . The FGFR receptor family . Receptor Tyrosine Kinases: Family and Subfamilies ,
Coleman SJ, Bruce C, Chioni A-M, Kocher HM, Grose RP ( 2014 ) . The ins and outs of fibroblast growth factor receptor signalling . Clin Sci (Lond) vol. 127 , ( 4 ) 217 - 231 .
Coleman SJ, Watt J, Arumugam P, Solaini L, Carapuca E, Ghallab M, Grose RP, Kocher HM ( 2014 ) . Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation . World J Gastroenterol vol. 20 , ( 26 ) 8471 - 8481 .
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T et al. ( 2014 ) . Identification of ZDHHC14 as a novel human tumour suppressor gene . J Pathol vol. 232 , ( 5 ) 566 - 577 .
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose RP ( 2014 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion . EMBO Mol Med vol. 6 , ( 4 ) 467 - 481 .
Coleman S, Chioni A-M, Ghallab M, Anderson R, Lemoine N, Kocher H, Grose R ( 2014 ) . Nuclear FGFR signalling as a driving force in pancreatic cancer . Pancreatology vol. 14 , ( 2 )
Fearon AE, Grose RP ( 2014 ) . Grb-ing receptor activation by the tail . Nat Struct Mol Biol vol. 21 , ( 2 ) 113 - 114 .
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T et al. ( 2014 ) . Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)) . Journal of Pathology vol. 234 , ( 1 )
Coleman SJ, Grose RP, Kocher HM ( 2014 ) . Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma . J Hepatocell Carcinoma vol. 1 , 43 - 54 .
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM et al. ( 2014 ) . Identification of ZDHHC14 as a novel human tumour suppressor: gene . INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE vol. 34 , S90 - S90 .
Fearon AE, Gould CR, Grose RP ( 2013 ) . FGFR signalling in women's cancers . Int J Biochem Cell Biol vol. 45 , ( 12 ) 2832 - 2842 .
Guasti L, Candy Sze WC, McKay T, Grose R, King PJ ( 2013 ) . FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development . Mol Cell Endocrinol vol. 371 , ( 1-2 ) 182 - 188 .
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . 538 Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . Gastroenterology vol. 144 , ( 5 ) s - 98 .
Coleman S, Chioni A-M, Ghallab M, Lemoine N, Grose RP, Kocher H ( 2013 ) . Nuclear Translocation of FGFR1 and FGF2 in Pancreatic Stellate Cells Is Necessary for Pancreatic Cancer Cell Invasion . GASTROENTEROLOGY . vol. 144 , S98 - S98 .
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F et al. ( 2013 ) . The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells . Oncogene vol. 32 , ( 6 ) 699 - 712 .
Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR, Grose RP ( 2013 ) . Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing . PLoS One vol. 8 , ( 11 )
Coleman SJ, Chioni A-M, Ghallab M, Anderson RK, Lemoine NR, Grose RP, Kocher HM ( 2013 ) . Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion . Pancreatology vol. 13 , ( 1 ) e10 - e11 .
Meyer M, Müller A-K, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R, Werner S ( 2012 ) . FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin . J Cell Sci vol. 125 , ( Pt 23 ) 5690 - 5701 .
Coleman S, Kocher H, Grose R ( 2012 ) . Abstract B65: Investigating the role of nuclear FGF2 signaling in pancreatic cancer . Conference: Tumor Biologyb65 - b65 .
Chioni A-M, Grose R ( 2012 ) . FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior . J Cell Biol vol. 197 , ( 6 ) 801 - 817 .
Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR et al. ( 2012 ) . Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris . J Pathol vol. 227 , ( 1 ) 81 - 93 .
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M et al. ( 2012 ) . Abstract 4858: Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers . Cancer Research vol. 72 , ( 8_Supplement ) 4858 - 4858 .
Jarosz M, Robbez-Masson L, Chioni A-M, Cross B, Rosewell I, Grose R ( 2012 ) . Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis . PLoS One vol. 7 , ( 6 )
Coleman SJ, Myrto-Chioni A, Grose RP, Kocher H ( 2011 ) . Investigating the Role of FGF Signaling in Pancreatic Cancer . Gastroenterology vol. 140 , ( 5 ) s - 714 .
Chioni A-M, Jones LJ, Grose RP ( 2011 ) . Abstract 1101: A novel role for FGFR in breast cancer . Cancer Research vol. 71 , ( 8_Supplement ) 1101 - 1101 .
Tsang S, Liu L, Teh M, Wheeler A, Piper K, Grose R, Hart I, Garrod D et al. ( 2010 ) . Novel role for human desmoglein 3 in regulating E-cadherin mediated adherens junctions through Src family kinase activation . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 130 , S33 - S33 .
Yang J, Meyer M, Müller A-K, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M et al. ( 2010 ) . Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis . J Cell Biol vol. 188 , ( 6 ) 935 - 952 .
Turner N, Grose R ( 2010 ) . Fibroblast growth factor signalling: from development to cancer . Nat Rev Cancer vol. 10 , ( 2 ) 116 - 129 .
Chioni A-M, Shao D, Grose R, Djamgoz MBA ( 2010 ) . Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration . Int J Biochem Cell Biol vol. 42 , ( 2 ) 346 - 358 .
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V et al. ( 2010 ) . Erratum: Regulation of lymphatic-blood vessel separation by endothelial Rac1 (Development vol. 136 (4043-4053)) . Development vol. 137 , ( 2 )
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F et al. ( 2010 ) . Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src . PloS ONE vol. 5 , ( 12 )
D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V et al. ( 2009 ) . Regulation of lymphatic-blood vessel separation by endothelial Rac1 . Development vol. 136 , ( 23 ) 4043 - 4053 .
Muller A, Yang J, Meyer M, Bohm F, Grose R, Partanen J, Ornitz D, Werner S ( 2009 ) . Control of epidermal barrier function and cutaneous homeostasis by FGF receptors 1 and 2 . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 129 , S85 - S85 .
Chioni A-M, Grose R ( 2009 ) . Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3) . Eur J Cell Biol vol. 88 , ( 7 ) 371 - 384 .
Chioni A-M, Grose R ( 2008 ) . Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis . Fibrogenesis Tissue Repair vol. 1 , ( 1 )
Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR et al. ( 2007 ) . The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development . EMBO J vol. 26 , ( 5 ) 1268 - 1278 .
Grose R ( 2006 ) . Fibroblast growth factor receptor 2-IIIb is a critical mediator of intercellular signalling in development and disease . J INVEST DERM SYMP P vol. 11 , ( 1 ) 142 - 142 .
Grose R, Dickson C ( 2005 ) . Fibroblast growth factor signaling in tumorigenesis . Cytokine Growth Factor Rev vol. 16 , ( 2 ) 179 - 186 .
Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C et al. ( 2005 ) . Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling . Nat Med vol. 11 , ( 2 ) 167 - 174 .
Grose R, Werner S ( 2004 ) . Wound-healing studies in transgenic and knockout mice . Mol Biotechnol vol. 28 , ( 2 ) 147 - 166 .
Zhang HB, Dessimoz J, Beyer TA, Krampert M, Williams LT, Werner S, Grose R ( 2004 ) . Fibroblast growth factor receptor 1-lllb is dispensable for skin morphogenesis and wound healing . EUR J CELL BIOL vol. 83 , ( 1 ) 3 - 11 .
Grose R ( 2004 ) . Common ground in the transcriptional profiles of wounds and tumors . Genome Biol vol. 5 , ( 6 )
Young P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P et al. ( 2003 ) . E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles . EMBO J vol. 22 , ( 21 ) 5723 - 5733 .
Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM, Dickson C ( 2003 ) . A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning . Development vol. 130 , ( 22 ) 5493 - 5501 .
Grose R ( 2003 ) . Epithelial migration: open your eyes to c-Jun . Curr Biol vol. 13 , ( 17 ) R678 - R680 .
Beyer TA, Werner S, Dickson C, Grose R ( 2003 ) . Fibroblast growth factor 22 and its potential role during skin development and repair . EXP CELL RES vol. 287 , ( 2 ) 228 - 236 .
Werner S, Grose R ( 2003 ) . Regulation of wound healing by growth factors and cytokines . Physiol Rev vol. 83 , ( 3 ) 835 - 870 .
Martin P, D'Souza D, Martin J, Grose R, Cooper L, Maki R, McKercher SR ( 2003 ) . Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells . Curr Biol vol. 13 , ( 13 ) 1122 - 1128 .
Grose R, Werner S ( 2003 ) . Wound Healing Studies in Transgenic and Knockout Mice . Wound Healing , vol. 78 ,
Grose R, Werner S ( 2003 ) . Wound healing studies in transgenic and knockout mice. A review . Methods Mol Med vol. 78 , 191 - 216 .
Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C, Martin P ( 2002 ) . Wound healing recapitulates morphogenesis in Drosophila embryos . NAT CELL BIOL vol. 4 , ( 11 ) 907 - 912 .
Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, Durka S, Reichardt HM, Werner S ( 2002 ) . A role for endogenous glucocorticoids in wound repair . EMBO Rep vol. 3 , ( 6 ) 575 - 582 .
Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fässler R, Brakebusch C, Werner S ( 2002 ) . A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair . Development vol. 129 , ( 9 ) 2303 - 2315 .
Grose R, Werner S ( 2002 ) . An aPPARently protective mechanism for keratinocytes in wounded skin . TRENDS MOL MED vol. 8 , ( 4 ) 149 - 151 .
Grose R, Harris BS, Cooper L, Topilko P, Martin P ( 2002 ) . Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse . Dev Dyn vol. 223 , ( 3 ) 371 - 378 .
Brakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, Svensson M, Herken R et al. ( 2000 ) . Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes . EMBO Journal vol. 19 , ( 15 ) 3990 - 4003 .
Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R, Werner S ( 2000 ) . The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 14 , ( 15 ) 2373 - 2376 .
Grose R, Martin P ( 1999 ) . Parallels between wound repair and morphogenesis in the embryo . Seminars in Cell and Developmental Biology vol. 10 , ( 4 ) 395 - 404 .