Publications: Prof Leonardo Guasti

Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG et al. ( 2023 ) . Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study . The Lancet Diabetes and Endocrinology vol. 11 , ( 8 ) 545 - 554 .

Williams JL, Smith C, Hall C, Khaled Z, Maharaj A, Kwong R, Pittaway J, Casas J et al. ( 2023 ) . Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma . European Journal of Endocrinology vol. 188 , ( 1 )

Mistry JN, Silvennoinen S, Zaman F, Sävendahl L, Mariniello K, Hall C, Howard SR, Dunkel L et al. ( 2023 ) . The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants . Frontiers in Endocrinology vol. 14 ,

Guasti L, Pittaway JFH ( 2022 ) . A new recipe for TARTs? One step closer in identifying the origin of testicular adrenal rest tumours . European Journal of Endocrinology vol. 187 , ( 6 ) C3 - C4 .

Hasan S, Delicata F, Guasti L, Duranti C, Haidar FM, Arcangeli A, Imbrici P, Pessia M et al. ( 2022 ) . Locus Coeruleus Neurons’ Firing Pattern Is Regulated by ERG Voltage-Gated K⁺ Channels . International Journal of Molecular Sciences vol. 23 , ( 23 )

Canton A, Tinano F, Guasti L, Montenegro L, Argente J, Ryan F, Shears D, Melo ME et al. ( 2022 ) . RF14 | PSAT120 X-Linked Central Precocious Puberty Associated with MECP2 Defects . Journal of the Endocrine Society vol. 6 , ( Suppl 1 ) a643 - a644 .

Pittaway J, Mariniello K, Altieri B, Sbiera I, Sbiera S, Chung T-T, Abdel-Azziz T, DiMarco A et al. ( 2022 ) . Delta-like non-canonical Notch ligand 1 (DLK1) - a novel biomarker in adrenocortical carcinoma . Endocrine Abstracts

Mariniello K, Pittaway J, Hadjidemetriou I, Borges K, Doroszko M, Doghman M, Lalli E, Rahman N et al. ( 2022 ) . Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice . Endocrine Abstracts

E RJ, Pinheiro-Machado CA, Tinano F, Guasti L, Ribeiro ML, Ryan F, Shears D, Paganoni A et al. ( 2022 ) . Variants in Methyl-CpG-binding protein 2 (MECP2) are associated with X-Linked Central Precocious Puberty . Endocrine Abstracts

T S, G R-B, A D, A M, K M, CP C, MR B, L D et al. ( 2022 ) . Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty .

Mariniello K, Guasti L, Rognoni E ( 2022 ) . DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland . Endocrine Abstracts

Williams J, Smith C, Hall C, Khaled Z, Maharaj A, Kwong R, Pittaway J, Casas J et al. ( 2022 ) . Elevated SGPL1 expression is associated with increased metabolic rate in cells and reduced survival in individuals with adrenocortical carcinoma . Endocrine Abstracts

van der Grinten HLC, Speiser PW, Faisal Ahmed S, Arlt W, Auchus RJ, Falhammar H, Flück CE, Guasti L et al. ( 2022 ) . Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management . Endocrine Reviews vol. 43 , ( 1 ) 91 - 159 .

Guasti L ( 2022 ) . Novel therapeutic models for adrenal disorders . SEXUAL DEVELOPMENT . vol. 16 , 11 - 12 .

Canton A, Tinano F, Guasti L, Montenegro L, Ryan F, Shears D, Melo ME, Gomes L et al. ( 2022 ) . X-Linked Central Precocious Puberty Associated with MECP2 defects . HORMONE RESEARCH IN PAEDIATRICS . vol. 95 , 363 - 364 .

Pittaway JFH, Lipsos C, Mariniello K, Guasti L ( 2021 ) . The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer . Endocrine-Related Cancer vol. 28 , ( 12 ) R271 - R287 .

Saengkaew T, Ruiz-Babot G, David A, Mancini A, Mariniello K, Cabrera CP, Barnes MR, Dunkel L et al. ( 2021 ) . Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty . npj Genomic Medicine vol. 6 , ( 1 )

Howard S, Saengkaew T, Dunkel L, Guasti L ( 2021 ) . Dominant mutations in CCDC141 are found by ehole rxome dequencing to be a common cause of self-limited delayed puberty . Endocrine Abstracts

Saengkaew T, Mancini A, Ruiz-Babot G, Cabrera CP, Barnes MR, Dunkel L, Guasti L, Howard S ( 2021 ) . Defects in the GnRH Neuronal Migration factor, CCDC141, Lead to Self-Limited Delayed Puberty . Journal of the Endocrine Society vol. 5 , ( Supplement_1 ) a665 - a666 .

Mariniello K, Guasti L ( 2021 ) . Towards novel treatments for adrenal diseases: Cell- and gene therapy-based approaches . Molecular and Cellular Endocrinology vol. 524 ,

Mancini A, Howard SR, Marelli F, Cabrera CP, Barnes MR, Sternberg MJE, Leprovots M, Hadjidemetriou I et al. ( 2020 ) . LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling . JCI Insight vol. 5 , ( 11 )

Mariniello K, Rognoni E, Guasti L ( 2020 ) . SUN-LB43 DLK1 Expressing Cells Contribute to the Zonation of the Adrenal Gland . Journal of the Endocrine Society vol. 4 , ( Suppl 1 ) sun - lb43 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Vassert G, Cariboni A et al. ( 2019 ) . Defects in LGR4 Wnt-[beta]-catenin signalling impair GnRH network development, leading to delayed puberty . Endocrine Abstracts

Mariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC, Guasti L ( 2019 ) . Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System . Frontiers in Endocrinology vol. 10 ,

Gualtieri A, Nicholson J, Tan R, Jimenez F, Dattani M, Guasti L, Gaston-Massuet C ( 2019 ) . Efnb2 controls pituitary gland development by regulating proliferation of the pituitary stem/progenitor cells and EMT within the pituitary stem cell niche . Endocrine Abstracts

Liew SY, Akker SA, Guasti L, Pittaway JFH ( 2019 ) . Glucocorticoid replacement therapies: past, present and future . Current Opinion in Endocrine and Metabolic Research vol. 8 , 152 - 159 .

A M, SR H, CP C, MR B, A D, K W, S H, A L et al. ( 2019 ) . EAP1 regulation of GnRH promoter activity is important for human pubertal timing .

SR H, R O, A P, V C, A F, G R-B, LA M, CP C et al. ( 2019 ) . HS6ST1 insufficiency causes self-limited delayed puberty in contrast with other GnRH deficiency genes .

Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL, Chan LF ( 2019 ) . ACTH signalling and adrenal development: Lessons from mouse models . Endocrine Connections vol. 8 , ( 7 ) R122 - R130 .

Hadjidemetriou I, Mariniello K, Ruiz-Babot G, Pittaway J, Mancini A, Mariannis D, Gomez-Sanchez CE, Parvanta L et al. ( 2019 ) . DLK1/PREF1 marks a novel cell population in the human adrenal cortex . The Journal of Steroid Biochemistry and Molecular Biology vol. 193 ,

Maharaj A, Maudhoo A, Chan LF, Novoselova T, Prasad R, Metherell LA, Guasti L ( 2019 ) . Isolated glucocorticoid deficiency: Genetic causes and animal models . Journal of Steroid Biochemistry and Molecular Biology vol. 189 , 73 - 80 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A et al. ( 2019 ) . EAP1 regulation of GnRH promoter activity is important for human pubertal timing . Human Molecular Genetics vol. 28 , ( 8 ) 1357 - 1368 .

Papathomas TG, Sun N, Chortis V, Taylor AE, Arlt W, Richter S, Eisenhofer G, Ruiz-Babot G et al. ( 2019 ) . Novel methods in adrenal research: a metabolomics approach . Histochemistry and Cell Biology vol. 151 , ( 3 ) 201 - 216 .

Saengkaew T, Mancini A, Ruiz-Babot G, Cabrera C, Barnes M, Dunkel L, Guasti L, Howard S ( 2019 ) . Defects in the GnRH Neuroendocrine Network Affect the Timing of Puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 91 , 67 - 67 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Vassart G, Cariboni A et al. ( 2019 ) . LGR 4-Wnt beta-catenin signalling directs GnRH network development, with defects leading to self-limited delayed puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 91 , 46 - 46 .

Guasti L ( 2019 ) . Novel interventions to treat adrenal insufficiency . HORMONE RESEARCH IN PAEDIATRICS . vol. 91 , 8 - 9 .

Pittaway JFH, Guasti L ( 2019 ) . Pathobiology and genetics of adrenocortical carcinoma . Journal of Molecular Endocrinology vol. 62 , ( 2 ) R105 - R119 .

Maharaj A, Buonocore F, Meimaridou E, Ruiz-Babot G, Guasti L, Peng HM, Capper CP, Burgos-Tirado N et al. ( 2019 ) . Predicted benign and synonymous variants in CYP11A1 cause primary adrenal insufficiency through missplicing . Journal of the Endocrine Society vol. 3 , ( 1 ) 201 - 221 .

Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF ( 2018 ) . MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation . FASEB Journal vol. 32 , ( 11 ) 6186 - 6196 .

G R-B, M B, I H, SJ A, DR T, L G, NF T, U S et al. ( 2018 ) . Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells .

Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP et al. ( 2018 ) . HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast with Other GnRH Deficiency Genes . Journal of Clinical Endocrinology and Metabolism vol. 103 , ( 9 ) 3420 - 3429 .

Guasti L, New SE, Hadjidemetriou I, Palmiero M, Ferretti P ( 2018 ) . Plasticity of human adipose-derived stem cells - relevance to tissue repair . Int J Dev Biol vol. 62 , ( 6-7-8 ) 431 - 439 .

Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G, Guasti L, Werdermann M, Ludwig B et al. ( 2018 ) . Expression of progenitor markers is associated with the functionality of a bioartificial adrenal cortex . PLoS One vol. 13 , ( 3 ) e0194643 - e0194643 .

Howard SR, Guasti L, Poliandri A, David A, Cabrera CP, Barnes MR, Wehkalampi K, O'Rahilly S et al. ( 2018 ) . Contributions of function-Altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty . Journal of Clinical Endocrinology and Metabolism vol. 103 , ( 2 ) 649 - 659 .

Ruiz-Babot G, Balyura M, Hadjidemetriou I, Ajodha SJ, Taylor DR, Ghataore L, Taylor NF, Schubert U et al. ( 2018 ) . Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells . Cell Reports vol. 22 , ( 5 ) 1236 - 1249 .

Mancini A, Howard SR, Cabrera CP, Barnes MR, Heger S, Guasti L, Ojeda S, Dunkel L ( 2018 ) . EAP1 Mutations Cause an Impaired Transcriptional Activity on GnRH Promoter That Leads to Self-Limited Delayed Puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 90 , 20 - 20 .

Howard S, Oleari R, Mancini A, Poliandri A, Saengkaew T, Guasti L, Cariboni A, Dunkel L ( 2018 ) . Role of GnRH Neuronal Migration and Development in Self-Limited Delayed Puberty . HORMONE RESEARCH IN PAEDIATRICS . vol. 90 , 68 - 68 .

Howard S, Andre V, Guasti L, Cabrera C, Barnes M, Cariboni A, Dunkel L ( 2017 ) . Patients with self-limited delayed puberty harbour mutations in multiple genes controlling GnRH neuronal development . Endocrine Abstracts

Maharaj A, Buonocore F, Meimaridou E, Ruiz-Babot G, Guasti L, Peng H-M, Capper C, Prasad R et al. ( 2017 ) . Predicted benign and silent SNPs in CYP11A1 cause primary adrenal insufficiency through missplicing . Endocrine Abstracts

Katugampola H, King PJ, Chatterjee S, Meso M, Duncan AJ, Achermann JC, Guasti L, Ghataore L et al. ( 2017 ) . Kisspeptin is a novel regulator of human fetal adrenocortical development and function – a finding with important implications for the human feto-placental unit . The Journal of Clinical Endocrinology & Metabolism

Poliandri A, Miller D, Howard S, Nobles M, Ruiz-Babot G, Harmer S, Tinker A, McKay T et al. ( 2017 ) . Generation of kisspeptin-responsive GnRH neurons from human pluripotent stem cells . Molecular and Cellular Endocrinology vol. 447 , 12 - 22 .

Tufton N, Roncaroli F, Hadjudemetriou I, Dang MN, Denes J, Guasti L, Thom M, Powell M et al. ( 2017 ) . Metastatic pituitary carcinoma in an SDHB mutation positive patient . Endocrine Abstracts

Tufton N, Roncaroli F, Hadjidemetriou I, Dang MN, Dénes J, Guasti L, Thom M, Powell M et al. ( 2017 ) . Pituitary Carcinoma in a Patient with an SDHB Mutation . Endocr Pathol vol. 28 , ( 4 ) 320 - 325 .

METHERELL LA, Prasad R, Storr HL, Guasti L, Maharaj A, Meimaridou E, Hadjidemetriou I ( 2017 ) . Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome . Journal of Clinical Investigation

Roncaroli F, Tufton N, Hadjidemetriou I, Dang MD, Guasti L, Powell M, Baldeweg E, Fersht N et al. ( 2017 ) . Pituitary carcinoma in a patient with germline Succinate Dehydrogenase B mutation . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . Conference: 118th Meeting of the British-Neuropathological-Society vol. 43 , 46 - 46 .

Howard SR, Andre V, Guasti L, Cabrera CP, Barnes MR, Cariboni A, Dunkel L ( 2017 ) . DISCOVERY OF MUTATIONS IN MULTIPLE GENES CONTROLLING GNRH NEURONAL MIGRATION AND DEVELOPMENT IN PATIENTS WITH SELF-LIMITED DELAYED PUBERTY . HORMONE RESEARCH IN PAEDIATRICS . vol. 88 , 59 - 59 .

Mistry JN, Ruiz-Babot G, Zaman F, Savendahl L, Guasti L, Dunkel L ( 2017 ) . MECHANISMS OF FIBROBLAST GROWTH FACTOR 21 (FGF21) MEDIATED GROWTH HORMONE RESISTANCE IN HUMAN GROWTH PLATE IN CHRONIC CHILDHOOD CONDITIONS . HORMONE RESEARCH IN PAEDIATRICS . vol. 88 , 4 - 4 .

GUASTI L ( 2016 ) . Towards reconstruction of epithelialized cartilages from autologous adipose tissue-derived stem cells . Journal of Tissue Engineering and Regenerative Medicine

Ruiz-Babot G, Hadjidemetriou I, Ajodha SJ, Ghataore L, Taylor D, Taylor N, Balyura M, Bornstein SR et al. ( 2016 ) . Generation of human urine-derived steroidogenic cells through lineage conversion: A new technology to study the adrenal gland . Endocrine Abstracts

Mancini A, Howard SR, Ruiz-Babot G, Cabrera CP, Barnes MR, Guasti L, Dunkel L . LGR4 and EAP1 mutations are implicated in the phenotype of self-limited delayed puberty . Endocrine Abstracts .

METHERELL LA ( 2016 ) . Mutations in SGPL1, encoding sphingosine-1-phosphate lyase, cause a novel form of primary adrenal insufficiency with steroid resistant nephrotic syndrome . Conference: Society for Endocrinology BES 2016 ( Brighton )

Narendra MJ, Ruiz-Babot G, Guasti L, Dunkel L . The mechanistic role of fibroblast growth factor 21 in growth hormone resistance secondary to chronic childhood conditions . Endocrine Abstracts .

Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn E, Gorrigan RJ, Tate P, Guasti L et al. ( 2016 ) . Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol . Journal of EndocrinologyJOE-16-0057 - JOE-16-0057 .

HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE et al. ( 2016 ) . IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty . EMBO Molecular Medicine vol. 8 , ( 6 ) 626 - 42 .

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2016 ) . Role of IGSF10 mutations in self-limited delayed puberty . The Lancet . vol. 387 ,

Howard S, Poliandre A, Storr HL, Metherell LA, Cabrera C, Warren H, Barnes M, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 cause self-limited delayed puberty (DP) in addition to idiopathic hypogonadotropic hypogonadism (IHH) . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Cabrera C et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty . Endocrine Abstracts

Babot GR, Hadjidemetriou I, Ajodha SJ, Taylor D, Taylor N, Guasti L ( 2015 ) . Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland . Endocrine Abstracts

Howard S, Poliandri A, Storr H, Metherell L, Cabrera C, Barnes M, Warren H, Wehkalampi K et al. ( 2015 ) . Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism . Endocrine Abstracts

Howard S, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell L, Sternberg M et al. ( 2015 ) . Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration . Endocrine Abstracts

Hadjidemetriou I, Ruiz-Babot G, Gomez-Sanchez C, King P, Guasti L ( 2015 ) . Unveiling the complexity of the undifferentiated zone in the human adrenal cortex . Endocrine Abstracts

Dentali F, Sironi AP, Gianni M, Orlandini F, Guasti L, Grandi AM, Franchini M, Ageno W et al. ( 2015 ) . Gender Difference in Efficacy and Safety of Nonvitamin K Antagonist Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation or Venous Thromboembolism: A Systematic Review and a Meta-Analysis of the Literature . Semin Thromb Hemost vol. 41 , ( 7 ) 774 - 787 .

Tamborini Permunian E, Riva N, Guasti L, Squizzato A ( 2015 ) . Cangrelor for the treatment of arterial thrombosis: pharmacokinetics/pharmacodynamics and clinical data . Expert Opin Drug Metab Toxicol vol. 11 , ( 4 ) 625 - 637 .

Ruiz-Babot G, Hadjidemetriou I, King PJ, Guasti L ( 2015 ) . New directions for the treatment of adrenal insufficiency . Frontiers in Endocrinology vol. 6 , ( MAY )

Galli L, Gerdes VEA, Guasti L, Squizzato A ( 2014 ) . Thrombosis Associated with Viral Hepatitis . J Clin Transl Hepatol vol. 2 , ( 4 ) 234 - 239 .

Guasti L, Silvennoinen S, Bulstrode NW, Ferretti P, Sankilampi U, Dunkel L ( 2014 ) . Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes . J Clin Endocrinol Metab vol. 99 , ( 11 ) E2198 - E2206 .

Katugampola H, Halder W, Ganatra R, Dunkel L, Storr H, Guasti L, King P ( 2014 ) . Expression of Sonic hedgehog signalling components in the developing human adrenal cortex . Endocrine Abstracts

Donadini MP, Dentali F, Squizzato A, Guasti L, Ageno W ( 2014 ) . Unsuspected pulmonary embolism in cancer patients: a narrative review with pooled data . Intern Emerg Med vol. 9 , ( 4 ) 375 - 384 .

Ferrari M, Guasti L, Maresca A, Mirabile M, Contini S, Grandi AM, Marino F, Cosentino M ( 2014 ) . Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2 . Eur J Clin Pharmacol vol. 70 , ( 5 ) 539 - 547 .

Dentali F, Gianni M, Mumoli N, Cei M, Bertolini A, Guasti L, Ageno W ( 2014 ) . Efficacy and safety of patent foramen ovale closure in patients with a cryptogenic stroke: Systematic review and meta-analysis . Thromb Haemost vol. 111 , ( 4 ) 773 - 776 .

Marino F, Maresca AM, Castiglioni L, Cosentino M, Maio RC, Schembri L, Klersy C, Mongiardi C et al. ( 2014 ) . Simvastatin down-regulates the production of interleukin-8 by neutrophil leukocytes from dyslipidemic patients . BMC Cardiovasc Disord vol. 14 ,

Howard S, Guasti L, Storr H, Metherell L, Cariboni A, Barnes M, Cabrera C, Wehkalampi K et al. ( 2014 ) . A novel gene affecting the timing of puberty . Endocrine Abstracts

Campiotti L, Maresca A, Guasti L, Grandi AM ( 2014 ) . Tirosine kinase inhibitors adverse events . Oncologist vol. 19 , ( 3 ) 306 - 307 .

Guasti L, Vagaska B, Bulstrode NW, Seifalian AM, Ferretti P ( 2014 ) . Chondrogenic differentiation of adipose tissue-derived stem cells within nanocaged POSS-PCU scaffolds: a new tool for nanomedicine . Nanomedicine vol. 10 , ( 2 ) 279 - 289 .

Grandi AM, Nicolini E, Rizzi L, Caputo S, Annoni F, Cremona AM, Marchesi C, Guasti L et al. ( 2014 ) . Dyslipidemia in HIV-positive patients: a randomized, controlled, prospective study on ezetimibe+fenofibrate versus pravastatin monotherapy . J Int AIDS Soc vol. 17 , ( 1 )

Falcone C, Matrone B, Bozzini S, Guasti L, Falcone R, Benzi A, Colonna A, Savulescu I et al. ( 2014 ) . Time-domain heart rate variability in coronary artery disease patients affected by thyroid dysfunction . Int Heart J vol. 55 , ( 1 ) 33 - 38 .

Bozzato S, Squizzato A, Donadini MP, Guasti L, Dentali F, Ageno W ( 2013 ) . Patient selection for thromboprophylaxis in medical inpatients . Expert Rev Cardiovasc Ther vol. 11 , ( 12 ) 1639 - 1647 .

Dentali F, Riva N, Turato S, Grazioli S, Squizzato A, Steidl L, Guasti L, Grandi AM et al. ( 2013 ) . Pulmonary embolism severity index accurately predicts long-term mortality rate in patients hospitalized for acute pulmonary embolism . J Thromb Haemost vol. 11 , ( 12 ) 2103 - 2110 .

Guasti L, Cavlan D, Cogger K, Banu Z, Shakur A, Latif S, King PJ ( 2013 ) . Dlk1 upregulates Gli1 expression in male rat adrenal capsule cells through the activation of β1 integrin and ERK1-2 . Endocrinology vol. 154 , ( 12 ) 4675 - 4684 .

Nicolini E, Martegani G, Maresca AM, Marchesi C, Dentali F, Lazzarini A, Speroni S, Guasti L et al. ( 2013 ) . Left ventricular remodeling in patients with metabolic syndrome: influence of gender . Nutr Metab Cardiovasc Dis vol. 23 , ( 8 ) 771 - 775 .

Donadini MP, Ageno W, Guasti L, Squizzato A ( 2013 ) . Certoparin for the treatment and prevention of thrombosis: pharmacological profile and results from clinical studies . Expert Opin Drug Metab Toxicol vol. 9 , ( 7 ) 901 - 909 .

Riva N, Ageno W, Guasti L, Squizzato A ( 2013 ) . Commentary . J Neurosci Rural Pract vol. 4 , ( 3 ) 367 - 369 .

Squizzato A, Rancan E, Dentali F, Bonzini M, Guasti L, Steidl L, Mathis G, Ageno W ( 2013 ) . Diagnostic accuracy of lung ultrasound for pulmonary embolism: a systematic review and meta-analysis . J Thromb Haemost vol. 11 , ( 7 ) 1269 - 1278 .

Guasti L, Candy Sze WC, McKay T, Grose R, King PJ ( 2013 ) . FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development . Mol Cell Endocrinol vol. 371 , ( 1-2 ) 182 - 188 .

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al. ( 2013 ) . Familial glucocorticoid deficiency: New genes and mechanisms . Molecular and Cellular Endocrinology vol. 371 , ( 1-2 ) 195 - 200 .

Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL et al. ( 2013 ) . Familial glucocorticoid deficiency: New genes and mechanisms . Mol Cell Endocrinol vol. 371 , ( 1-2 ) 195 - 200 .

Yates R, Katugampola H, Cavlan D, Cogger K, Meimaridou E, Hughes C, Metherell L, Guasti L et al. ( 2013 ) . Adrenocortical development, maintenance, and disease . Curr Top Dev Biol vol. 106 , 239 - 312 .

Marino F, Guasti L, Tozzi M, Schembri L, Castiglioni L, Molteni E, Piffaretti G, Castelli P et al. ( 2013 ) . Gene expression of adhesion molecules in endothelial cells from patients with peripheral arterial disease is reduced after surgical revascularization and pharmacological treatment . Int J Vasc Med vol. 2013 ,

Falcone C, Bozzini S, Guasti L, D'Angelo A, Capettini AC, Paganini EM, Falcone R, Moia R et al. ( 2013 ) . Soluble RAGE plasma levels in patients with coronary artery disease and peripheral artery disease . ScientificWorldJournal vol. 2013 ,

Marino F, Maresca AM, Cosentino M, Castiglioni L, Rasini E, Mongiardi C, Maio RC, Legnaro M et al. ( 2012 ) . Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment . Cardiovasc Diabetol vol. 11 ,

Squizzato A, Guasti L, Ageno W ( 2012 ) . Statins are better than fibrates in patients with a previous venous thromboembolism . Thromb Res vol. 130 , ( 6 ) 831 - 832 .

Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V, King P ( 2012 ) . The role of primary cilia in mouse adrenal and zebrafish interrenal development . Cilia vol. 1 , ( Suppl 1 )

Grandi AM, Nicolini E, Giola M, Gianni M, Maresca AM, Marchesi C, Guasti L, Balsamo ML et al. ( 2012 ) . Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection . J Hum Hypertens vol. 26 , ( 10 ) 570 - 576 .

Kowalczyk⁎ J, Meimaridou E, Guasti L, Lei XG, Clark AJL, Metherell et al LA ( 2012 ) . A homozygous glutathione peroxidase 1 mutation, p. Arg130-Leu133del, in a patient with familial glucocorticoid deficiency . Free Radical Biology and Medicine . vol. 53 , s220 - s221 .

Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, Nürnberg P, Mann NP et al. ( 2012 ) . Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency . Nat Genet vol. 44 , ( 7 ) 740 - 742 .

Guasti L, Prasongchean W, Kleftouris G, Mukherjee S, Thrasher A, Bulstrode N, Ferretti P ( 2012 ) . High plasticity of pediatric adipose-derived stem cells: too much for selective skeletogenic differentiation? . Stem Cells Trans Med vol. 1 , ( 5 ) Article sctm.2012-0009 , 384 - 395 .

Hughes CR, Guasti L, Meimaridou E, Chuang C-H, Schimenti JC, King PJ, Costigan C, Clark AJL et al. ( 2012 ) . MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans . JOURNAL OF CLINICAL INVESTIGATION vol. 122 , ( 3 ) 814 - 820 .

Grandi AM, Laurita E, Marchesi C, Maresca AM, Solbiati F, Bernasconi A, Marogna M, Salina C et al. ( 2012 ) . OSA, metabolic syndrome and CPAP: effect on cardiac remodeling in subjects with abdominal obesity . Respir Med vol. 106 , ( 1 ) 145 - 152 .

Marchesi C, Dentali F, Nicolini E, Maresca AM, Tayebjee MH, Franz M, Guasti L, Venco A et al. ( 2012 ) . Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis . J Hypertens vol. 30 , ( 1 ) 3 - 16 .

Maroni L, Guasti L, Castiglioni L, Marino F, Contini S, Macchi V, De Leo A, Gaudio G et al. ( 2011 ) . Lipid targets during statin treatment in dyslipidemic patients affected by nonalcoholic fatty liver disease . Am J Med Sci vol. 342 , ( 5 ) 383 - 387 .

Cooray SN, Guasti L, Clark AJL ( 2011 ) . The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor . Endocrinology vol. 152 , ( 11 ) 4224 - 4231 .

Guasti L, Dentali F, Castiglioni L, Maroni L, Marino F, Squizzato A, Ageno W, Gianni M et al. ( 2011 ) . Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjects . Thromb Haemost vol. 106 , ( 4 ) 591 - 599 .

Dentali F, Gianni M, Squizzato A, Ageno W, Castiglioni L, Maroni L, Hylek EM, Grandi AM et al. ( 2011 ) . Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. A systematic review and meta-analysis . Thromb Haemost vol. 106 , ( 2 ) 363 - 370 .

Gorrigan RJ, Guasti L, King P, Clark AJ, Chan LF ( 2011 ) . Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland . J Mol Endocrinol vol. 46 , ( 3 ) 227 - 232 .

Guasti L, Paul A, Laufer E, King P ( 2011 ) . Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex . Mol Cell Endocrinol vol. 336 , ( 1-2 ) 117 - 122 .

Guasti L, Marino F, Cosentino M, Maroni L, Maresca AM, Colombo F, Maio RC, Castiglioni L et al. ( 2011 ) . Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea . Sleep Breath vol. 15 , ( 1 ) 3 - 11 .

Dentali F, Guasti L ( 2010 ) . Are statins effective in high-risk primary prevention? . Arch Intern Med vol. 170 , ( 22 ) 2042 - 2043 .

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G et al. ( 2010 ) . Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families . Hum Mutat vol. 31 , ( 8 ) 950 - 960 .

Congiu T, Schembri L, Tozzi M, Guasti L, Maio RC, Cosentino M, Marino F ( 2010 ) . Scanning electron microscopy examination of endothelium morphology in human carotid plaques . Micron vol. 41 , ( 5 ) 532 - 536 .

Guasti L, Mainardi LT, Baselli G, Simoni C, Cimpanelli M, Braga SS, Pedretti R, Castiglioni L et al. ( 2010 ) . Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control . J Hum Hypertens vol. 24 , ( 6 ) 417 - 426 .

Guasti L, Marino F, Congiu T, Tozzi M, Schembri L, Maio RC, Castiglioni L, Maroni L et al. ( 2010 ) . Laminar pattern of mineral calcium-phosphorus deposits in a human carotid plaque: nanoscale ultrastructure and elemental analysis . Circulation vol. 121 , ( 17 ) 1971 - 1973 .

Squizzato A, Galli M, Romualdi E, Dentali F, Kamphuisen PW, Guasti L, Venco A, Ageno W ( 2010 ) . Statins, fibrates, and venous thromboembolism: a meta-analysis . Eur Heart J vol. 31 , ( 10 ) 1248 - 1256 .

Marino F, Guasti L, Tozzi M, Consuelo Maio R, Castiglioni L, Rasini E, Schembri L, Maroni L et al. ( 2009 ) . Angiotensin type 1 receptor expression and interleukin-8 production in polymorphonuclear leukocytes of patients with peripheral arterial disease . J Cardiovasc Pharmacol vol. 54 , ( 6 ) 520 - 525 .

Guasti L, Richardson D, Jhaveri M, Eldeeb K, Barrett D, Elphick MR, Alexander SPH, Kendall D et al. ( 2009 ) . Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain . Mol Pain vol. 5 ,

Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M et al. ( 2009 ) . MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family . Proc Natl Acad Sci U S A vol. 106 , ( 15 ) 6146 - 6151 .

Guasti L, Simoni C, Mainardi L, Crespi C, Cimpanelli MG, Klersy C, Gaudio G, Codari R et al. ( 2009 ) . Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects . Int J Psychophysiol vol. 71 , ( 3 ) 258 - 263 .

Pessia M, Servettini I, Panichi R, Guasti L, Grassi S, Arcangeli A, Wanke E, Pettorossi VE ( 2008 ) . ERG voltage-gated K⁺ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones . Journal of Physiology vol. 586 , ( 20 ) 4877 - 4890 .

King PJ, Guasti L, Laufer E ( 2008 ) . Hedgehog signalling in endocrine development and disease . J ENDOCRINOL vol. 198 , ( 3 ) 439 - 450 .

Guasti L, Crociani O, Redaelli E, Pillozzi S, Polvani S, Masselli M, Mello T, Galli A et al. ( 2008 ) . Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells . Mol Cell Biol vol. 28 , ( 16 ) 5043 - 5060 .

Schembri L, Congiu T, Tozzi M, Guasti L, Cosentino M, Marino F ( 2008 ) . Images in cardiovascular medicine. Scanning electron microscopy examination and elemental analysis of atherosclerotic calcifications in a human carotid plaque . Circulation vol. 117 , ( 23 ) e479 - e480 .

Marino F, Guasti L, Cosentino M, Rasini E, Ferrari M, Maio RC, Loraschi A, Cimpanelli MG et al. ( 2008 ) . Simvastatin treatment in subjects at high cardiovascular risk modulates AT1R expression on circulating monocytes and T lymphocytes . J Hypertens vol. 26 , ( 6 ) 1147 - 1155 .

Guasti L, Marino F, Cosentino M, Maio RC, Rasini E, Ferrari M, Castiglioni L, Klersy C et al. ( 2008 ) . Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up . Eur Heart J vol. 29 , ( 9 ) 1118 - 1126 .

Grandi AM, Solbiati F, Laurita E, Maresca AM, Nicolini E, Marchesi C, Gianni M, Guasti L et al. ( 2008 ) . Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study . Am J Hypertens vol. 21 , ( 2 ) 231 - 237 .

Marchesi C, Maresca AM, Solbiati F, Franzetti I, Laurita E, Nicolini E, Gianni M, Guasti L et al. ( 2007 ) . Masked hypertension in type 2 diabetes mellitus. Relationship with left-ventricular structure and function . Am J Hypertens vol. 20 , ( 10 ) 1079 - 1084 .

Marino F, Guasti L, Cosentino M, Ferrari M, Rasini E, Maio RC, Cimpanelli MG, Cereda E et al. ( 2007 ) . Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin . J Cardiovasc Pharmacol vol. 49 , ( 5 ) 299 - 305 .

Grandi AM, Laurita E, Marchesi C, Maresca A, Solbiati F, Nicolini E, Gianni M, Guasti L et al. ( 2007 ) . Family history of hypertension influences left ventricular diastolic function during chronic antihypertensive therapy . Am J Hypertens vol. 20 , ( 4 ) 410 - 415 .

Guasti L, Simoni C, Scamoni C, Sarzi Braga S, Crespi C, Cimpanelli M, Grandi AM, Pedretti R et al. ( 2007 ) . An unusual case presenting with hypertensive crisis . Intern Emerg Med vol. 2 , ( 1 ) 29 - 32 .

Furlan F, Taccola G, Grandolfo M, Guasti L, Arcangeli A, Nistri A, Ballerini L ( 2007 ) . ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord . Journal of Neuroscience vol. 27 , ( 4 ) 919 - 928 .

Guasti L, Marino F, Cosentino M, Cimpanelli M, Piantanida E, Mainardi LT, Vanoli P, De Palma D et al. ( 2007 ) . Changes in autonomic modulation to the heart and intracellular catecholamines. A longitudinal study in differentiated thyroid carcinoma during short-term hypothyroidism and thyroid hormone replacement . Horm Res vol. 67 , ( 4 ) 171 - 178 .

Guasti L, Marino F, Cosentino M, Cimpanelli M, Rasini E, Piantanida E, Vanoli P, De Palma D et al. ( 2007 ) . Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: a longitudinal study in hypothyroidism and during hormone treatment . Clin J Pain vol. 23 , ( 6 ) 518 - 523 .

Guasti L, Simoni C, Scamoni C, Sarzi Braga S, Crespi C, Cimpanelli M, Gaudio G, Pedretti R et al. ( 2006 ) . Mixed cranial nerve neuroma revealing itself as baroreflex failure . Auton Neurosci vol. 130 , ( 1-2 ) 57 - 60 .

Guasti L, Marino F, Cosentino M, Cimpanelli M, Maio RC, Klersy C, Crespi C, Restelli D et al. ( 2006 ) . Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study . J Hypertens vol. 24 , ( 12 ) 2423 - 2430 .

Grandi AM, Laurita E, Solbiati F, Marchesi C, Maresca AM, Nicolini E, Guasti L, Venco A ( 2006 ) . Angiotensin-converting enzyme inhibitors influence left ventricular mass and function independently of the antihypertensive effect . J Cardiovasc Pharmacol vol. 48 , ( 5 ) 207 - 211 .

Rasini E, Cosentino M, Marino F, Legnaro M, Ferrari M, Guasti L, Venco A, Lecchini S ( 2006 ) . Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study . Regul Pept vol. 134 , ( 2-3 ) 69 - 74 .

Restano R, Korolkova Y, Diochot S, Gurrola G, Guasti L, Possani L, Lazdunski E, Arcangeli A et al. ( 2006 ) . Species diversity and peptide toxin blocking selectively of ERG subfamily K+ channels in the central nervous system . Mol Pharm vol. 69 , ( 5 ) 1673 - 83 .

Marino F, Guasti L, Cosentino M, De Piazza D, Simoni C, Piantanida E, Cimpanelli M, Klersy C et al. ( 2006 ) . Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy . Life Sci vol. 78 , ( 10 ) 1071 - 1077 .

Grandi AM, Maresca AM, Giudici E, Laurita E, Marchesi C, Solbiati F, Nicolini E, Guasti L et al. ( 2006 ) . Metabolic syndrome and morphofunctional characteristics of the left ventricle in clinically hypertensive nondiabetic subjects . Am J Hypertens vol. 19 , ( 2 ) 199 - 205 .

Grandi AM, Piantanida E, Franzetti I, Bernasconi M, Maresca A, Marnini P, Guasti L, Venco A ( 2006 ) . Effect of glycemic control on left ventricular diastolic function in type 1 diabetes mellitus . Am J Cardiol vol. 97 , ( 1 ) 71 - 76 .

Marino F, Guasti L, Cosentino M, De Piazza D, Simoni C, Bianchi V, Piantanida E, Saporiti F et al. ( 2006 ) . Thyroid hormone and thyrotropin regulate intracellular free calcium concentrations in human polymorphonuclear leukocytes: in vivo and in vitro studies . Int J Immunopathol Pharmacol vol. 19 , ( 1 ) 149 - 160 .

Guasti L, Cilia E, Crociani O, Hofmann G, Polvani S, Becchetti A, Wanke E, Tempia F et al. ( 2005 ) . Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits . J Comp Neurol vol. 491 , ( 2 ) 157 - 174 .

Guasti L, Simoni C, Mainardi L, Crespi C, Cimpanelli M, Klersy C, Gaudio G, Grandi AM et al. ( 2005 ) . Global link between heart rate and blood pressure oscillations at rest and during mental arousal in normotensive and hypertensive subjects . Auton Neurosci vol. 120 , ( 1-2 ) 80 - 87 .

Guasti L, Simoni C, Mainardi LT, Cimpanelli M, Crespi C, Gaudio G, Clersy C, Grandi AM et al. ( 2005 ) . Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node . Acta Cardiol vol. 60 , ( 3 ) 319 - 324 .

Cherubini A, Hofmann G, Pillozzi S, Guasti L, Crociani O, Cilia E, Di Stefano P, Degani S et al. ( 2005 ) . Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling . Mol Biol Cell vol. 16 , ( 6 ) 2972 - 2983 .

Gaudio G, Guasti L, Schizzarotto A, Simoni C, Crespi C, Cimpanelli M, Klersy C, Grandi AM et al. ( 2005 ) . Changes in plasma lipids during renin-angiotensin system blockade by combination therapy (enalapril plus valsartan) in patients with diabetes and hypertension . J Cardiovasc Pharmacol vol. 45 , ( 4 ) 362 - 366 .

Furlan* F, Guasti* L, Avossa D, Becchetti A, Cilia E, Ballerini L, Arcangeli A ( 2005 ) . Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro . Neuroscience vol. 135 , ( 4 ) 1179 - 1192 .

Grandi AM, Solbiati F, Laurita E, Cassinerio E, Marchesi C, Piperno F, Maresca A, Guasti L et al. ( 2005 ) . Isolated office hypertension: a 3-year follow-up study . Blood Press vol. 14 , ( 5 ) 298 - 305 .

Arcangeli A, Becchetti A, Cherubini A, Crociani O, Defilippi P, Guasti L, Hofmann G, Pillozzi S et al. ( 2004 ) . Physical and functional interaction between integrins and hERG potassium channels . Biochemical Society Transactions vol. 32 , ( 5 ) 826 - 827 .

Arcangeli A, Becchetti A, Cherubini A, Crociani O, Defilippi P, Guasti L, Hofmann G, Pillozzi S et al. ( 2004 ) . Physical and functional interaction between integrins and hERG potassium channels . Biochem Soc Trans vol. 32 , ( Pt 5 ) 826 - 827 .

Grandi AM, Laurita E, Selva E, Piantanida E, Imperiale D, Giovanella L, Guasti L, Venco A ( 2004 ) . Natriuretic peptides as markers of preclinical cardiac disease in obesity . Eur J Clin Invest vol. 34 , ( 5 ) 342 - 348 .

Lastraioli* E, Guasti* L, Crociani O, Polvani S, Hofmann G, Witchel H, Bencini L, Calistri M et al. ( 2004 ) . herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells . Cancer Res vol. 64 , ( 2 ) 606 - 611 .

Crociani O, Guasti L, Balzi M, Becchetti A, Wanke E, Olivotto M, Wymore RS, Arcangeli A ( 2003 ) . Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells . J Biol Chem vol. 278 , ( 5 ) 2947 - 2955 .

Gullo F, Ales E, Rosati B, Lecchi M, Masi A, Guasti L, Cano-Abad MF, Arcangeli A et al. ( 2003 ) . ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 17 , ( 2 ) 330 - 332 .

Grandi AM, Imperiale D, Santillo R, Barlocco E, Bertolini A, Guasti L, Venco A ( 2002 ) . Aldosterone antagonist improves diastolic function in essential hypertension . Hypertension vol. 40 , ( 5 ) 647 - 652 .

Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A et al. ( 2002 ) . HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors . Leukemia vol. 16 , ( 9 ) 1791 - 1798 .

Guasti L, Zanotta D, Mainardi LT, Petrozzino MR, Grimoldi P, Garganico D, Diolisi A, Gaudio G et al. ( 2002 ) . Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity . Auton Neurosci vol. 99 , ( 2 ) 127 - 133 .

Grandi AM, Broggi R, Jessula A, Laurita E, Cassinerio E, Piperno F, Bertolini A, Guasti L et al. ( 2002 ) . Relation of extent of nocturnal blood pressure decrease to cardiovascular remodeling in never-treated patients with essential hypertension . Am J Cardiol vol. 89 , ( 10 ) 1193 - 1196 .

Guasti L, Zanotta D, Diolisi A, Garganico D, Simoni C, Gaudio G, Grandi AM, Venco A ( 2002 ) . Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade . J Hypertens vol. 20 , ( 3 ) 485 - 491 .

Cherubini A, Pillozzi S, Hofmann G, Crociani O, Guasti L, Lastraioli E, Polvani S, Masi A et al. ( 2002 ) . HERG K⁺ channels and β1 integrins interact through the assembly of a macromolecular complex . Annals of the New York Academy of Sciences vol. 973 , 559 - 561 .

Grandi AM, Broggi R, Colombo S, Santillo R, Imperiale D, Bertolini A, Guasti L, Venco A ( 2001 ) . Left ventricular changes in isolated office hypertension: a blood pressure-matched comparison with normotension and sustained hypertension . Arch Intern Med vol. 161 , ( 22 ) 2677 - 2681 .

Guasti L, Petrozzino MR, Mainardi LT, Grimoldi P, Zanotta D, Garganico D, Diolisi A, Simoni C et al. ( 2001 ) . Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertensive patients . Acta Cardiol vol. 56 , ( 5 ) 289 - 295 .

Grandi AM, Zanzi P, Broggi R, Fachinetti A, Guasti L, Ceriani L, Venco A ( 2001 ) . Longitudinal changes of insulin sensitivity in essential hypertension: influence of blood pressure control and familial predisposition to hypertension . J Clin Endocrinol Metab vol. 86 , ( 7 ) 3027 - 3031 .

Grandi AM, Santillo R, Bertolini A, Imperiale D, Broggi R, Colombo S, Selva E, Jessula A et al. ( 2001 ) . Microalbuminuria as a marker of preclinical diastolic dysfunction in never-treated essential hypertensives . Am J Hypertens vol. 14 , ( 7 Pt 1 ) 644 - 648 .

Hofmann G, Bernabei PA, Crociani O, Cherubini A, Guasti L, Pillozzi S, Lastraioli E, Polvani S et al. ( 2001 ) . HERG K⁺ Channels Activation during β<inf>1</inf> Integrin-mediated Adhesion to Fibronectin Induces an Up-regulation of αvβ<inf>3</inf> Integrin in the Preosteoclastic Leukemia Cell Line FLG 29.1 . Journal of Biological Chemistry vol. 276 , ( 7 ) 4923 - 4931 .

Hofmann G, Bernabei PA, Crociani O, Cherubini A, Guasti L, Lastraioli E, Polvani S, Bartolozzi B et al. ( 2001 ) . HERG K channels activation during β1 integrin-mediated adhesion to fibronectin induces an up regulation of αvβ3 integrin in the preosteoclastic leukemia cell line . J Biol Chem4923 - 31 .

Grandi AM, Zanzi P, Piantanida E, Gaudio G, Bertolini A, Guasti L, Venco A ( 2000 ) . Obesity and left ventricular diastolic function: noninvasive study in normotensives and newly diagnosed never-treated hypertensives . Int J Obes Relat Metab Disord vol. 24 , ( 8 ) 954 - 958 .

Grandi AM, Santillo R, Zanzi P, Broggi R, Imperiale D, Colombo S, Bertolini A, Jessula A et al. ( 2000 ) . Microalbuminuria in never-treated hypertensives: lack of relationship to hyperinsulinemia and genetic predisposition to hypertension . Am J Hypertens vol. 13 , ( 4 Pt 1 ) 353 - 358 .

Grandi AM, Zanzi P, Fachinetti A, Gaudio G, Ceriani L, Bertolini A, Guasti L, Venco A ( 1999 ) . Insulin and diastolic dysfunction in lean and obese hypertensives: genetic influence . Hypertension vol. 34 , ( 6 ) 1208 - 1214 .

Guasti L, Zanotta D, Petrozzino MR, Grimoldi P, Diolisi A, Garganico D, Gaudio G, Grandi AM et al. ( 1999 ) . Relationship between dental pain perception and 24 hour ambulatory blood pressure: a study on 181 subjects . J Hypertens vol. 17 , ( 12 Pt 2 ) 1799 - 1804 .

Guasti L, Gaudio G, Zanotta D, Grimoldi P, Petrozzino MR, Tanzi F, Bertolini A, Grandi AM et al. ( 1999 ) . Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity . Pain vol. 82 , ( 3 ) 311 - 317 .

Guasti L, Grimoldi P, Mainardi LT, Petrozzino MR, Piantanida E, Garganico D, Diolisi A, Zanotta D et al. ( 1999 ) . Autonomic function and baroreflex sensitivity during a normal ovulatory cycle in humans . Acta Cardiol vol. 54 , ( 4 ) 209 - 213 .

Grandi AM, Broggi R, Zanzi P, Gaudio G, Santillo R, Lamponi M, Bertolini A, Guasti L et al. ( 1999 ) . Individualized versus standardized analysis of ambulatory blood pressure profile: relationship with left ventricular characteristics . Blood Press Monit vol. 4 , ( 1 ) 7 - 11 .

Guasti L, Diolisi A, Gaudio G, Grimoldi P, Petrozzino R, Uslenghi S, Bertolini A, Grandi AM et al. ( 1998 ) . Reactivity of blood pressure to mental arithmetic stress test, stress-test recovery time, and ambulatory blood pressure in hypertensive and normotensive subjects . Blood Press Monit vol. 3 , ( 5 ) 275 - 280 .

Grandi AM, Gaudio G, Fachinetti A, Piantanida E, Zanzi P, Ceriani L, Guasti L, Venco A ( 1998 ) . Insulin sensitivity in obese normotensive adults: influence of family history of hypertension . Int J Obes Relat Metab Disord vol. 22 , ( 9 ) 910 - 914 .

Guasti L, Grimoldi P, Diolisi A, Petrozzino MR, Gaudio G, Grandi AM, Rossi MG, Venco A ( 1998 ) . Treatment with enalapril modifies the pain perception pattern in hypertensive patients . Hypertension vol. 31 , ( 5 ) 1146 - 1150 .

Grandi AM, Gaudio G, Fachinetti A, Zanzi P, Bianchi L, Ceriani L, Guasti L, Venco A ( 1997 ) . Influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects . Eur J Clin Invest vol. 27 , ( 9 ) 774 - 779 .

Grandi AM, Zanzi P, Ceriani L, Gaudio G, Bertolini A, Giovanella L, Guasti L, Roncari G et al. ( 1997 ) . Relationship between left ventricular diastolic function and atrial natriuretic factor in never-treated mild hypertensives . Am J Hypertens vol. 10 , ( 8 ) 946 - 950 .

Grandi AM, Pinotti G, Morandi E, Zanzi P, Bulgheroni P, Guasti L, Bertolini A, Venco A ( 1997 ) . Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic acid: a one-year follow-up study . Ann Oncol vol. 8 , ( 7 ) 705 - 708 .

Guasti L, Grimoldi P, Ceriani L, Gaudio G, Bertolini A, Giovanella L, Grandi AM, Roncari G et al. ( 1997 ) . Atrial natriuretic peptide and 24 h blood pressure . Blood Press Monit vol. 2 , ( 2 ) 89 - 92 .

Guasti L, Marino F, Gaudio G, Cosentino M, Diolisi A, Bertolini A, Grandi AM, Lecchini S et al. ( 1997 ) . Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines . Acta Cardiol vol. 52 , ( 6 ) 485 - 494 .

Grandi AM, Bignotti M, Bertolini A, Gaudio G, Zanzi P, Guasti L, Nardo B, Venco A ( 1997 ) . Clinical feasibility of echocardiographic automated border detection in monitoring left ventricular response to acute changes of preload in normal subjects . Cardiology vol. 88 , ( 4 ) 393 - 396 .

Guasti L, Cattaneo R, Daneri A, Bianchi L, Gaudio G, Regazzi MB, Grandi AM, Bertolini A et al. ( 1996 ) . Endogenous beta-endorphins in hypertension: correlation with 24-hour ambulatory blood pressure . J Am Coll Cardiol vol. 28 , ( 5 ) 1243 - 1248 .

Grandi AM, Gaudio G, Fachinetti A, Bianchi L, Nardo B, Zanzi P, Ceriani L, Guasti L et al. ( 1996 ) . Hyperinsulinemia, family history of hypertension, and essential hypertension . Am J Hypertens vol. 9 , ( 8 ) 732 - 738 .

Guasti L, Merlo B, Verga R, Cattaneo R, Gaudio G, Bianchi L, Zanzi P, Grandi AM et al. ( 1995 ) . Effects of arithmetic mental stress test on hypertension-related hypalgesia . J Hypertens vol. 13 , ( 12 Pt 2 ) 1631 - 1635 .

Grandi AM, Bignotti M, Gaudio G, Zanzi P, Guasti L, Venco A ( 1995 ) . Ambulatory blood pressure and left ventricular changes during antihypertensive treatment: perindopril versus isradipine . J Cardiovasc Pharmacol vol. 26 , ( 5 ) 737 - 741 .

Guasti L, Cattaneo R, Rinaldi O, Rossi MG, Bianchi L, Gaudio G, Grandi AM, Gorini G et al. ( 1995 ) . Twenty-four-hour noninvasive blood pressure monitoring and pain perception . Hypertension vol. 25 , ( 6 ) 1301 - 1305 .

Bignotti M, Grandi AM, Gaudio G, Guasti L, Venco A ( 1995 ) . One-year antihypertensive treatment with amlodipine: effects on 24-hour blood pressure and left ventricular anatomy and function . Acta Cardiol vol. 50 , ( 2 ) 135 - 142 .

Falcone C, Guasti L, Ochan M, Codega S, Tortorici M, Angoli L, Bergamaschi R, Montemartini C ( 1993 ) . Beta-endorphins during coronary angioplasty in patients with silent or symptomatic myocardial ischemia . J Am Coll Cardiol vol. 22 , ( 6 ) 1614 - 1620 .

Specchia G, Falcone C, Traversi E, La Rovere MT, Guasti L, De Micheli G, Ardissino D, De Servi S ( 1991 ) . Mental stress as a provocative test in patients with various clinical syndromes of coronary heart disease . Circulation vol. 83 , ( 4 Suppl ) II108 - II114 .

Specchia G, Falcone C, Tortorici M, Cioffi P, Ghio S, Ciardelli L, Guasti L, Rondanelli R ( 1990 ) . Silent ischemia during PTCA: its relationship with exercise-induced silent ischemia and the possible role for beta-endorphins . Adv Cardiol vol. 37 , 165 - 175 .

Salerno JA, Guasti L, Panciroli C, Chimienti M, Previtali M, Bobba P ( 1990 ) . Syncope and sudden death due to vasospastic myocardial ischemia in young sportmen . Cardiologia vol. 35 , ( 1 Suppl ) 69 - 72 .

Costantini M, Chimienti M, Zardini M, Klersy C, Guasti L, Salerno JA ( 1989 ) . [An electrophysiologic and electropharmacological study of functional properties of the bundle of Kent in Wolff-Parkinson-White syndrome] . Cardiologia vol. 34 , ( 4 ) 365 - 374 .

Falcone C, Sconocchia R, Guasti L, Codega S, Montemartini C, Specchia G ( 1988 ) . Dental pain threshold and angina pectoris in patients with coronary artery disease . J Am Coll Cardiol vol. 12 , ( 2 ) 348 - 352 .

Klersy C, Marangoni E, Salerno JA, Guasti L, Chimienti M, Morellini MC, li Bergolis M, Moizi M et al. ( 1988 ) . [Intravenous flecainide in Wolff-Parkinson-White syndrome: a test for evaluation of the refractory period of the anomalous pathway. Comparison with ajmaline] . Cardiologia vol. 33 , ( 5 ) 531 - 535 .

Falcone C, Specchia G, Rondanelli R, Guasti L, Corsico G, Codega S, Montemartini C ( 1988 ) . Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease . J Am Coll Cardiol vol. 11 , ( 4 ) 719 - 723 .

Salerno JA, Klersy C, Minzioni G, Guasti L, Chimienti M, Zardini M, Viganò M ( 1988 ) . [Therapy of arrhythmia by ablation technics with catheters and with surgical technics] . Cardiologia vol. 33 , ( 3 ) 237 - 241 .

Salerno JA, Klersy C, Chimienti M, Zardini M, Guasti L, Marangoni E, Previtali M ( 1987 ) . [Paroxysmal ventricular tachycardias] . Cardiologia vol. 32 , ( 12 ) 1675 - 1683 .

Chimienti M, Moizi M, Salerno JA, Klersy C, Guasti L, Previtali M, Marangoni E, Montemartini C et al. ( 1987 ) . Electrophysiologic and clinical effects of intravenous and oral encainide in patients with Wolff-Parkinson-White syndrome and paroxysmal atrial fibrillation . Eur Heart J vol. 8 , ( 3 ) 282 - 290 .

Chimienti M, Moizi M, Klersy C, Guasti L, Salerno JA ( 1987 ) . A modified ajmaline test for prediction of the effective refractory period of the accessory pathway in the Wolff-Parkinson-White syndrome . Am J Cardiol vol. 59 , ( 1 ) 164 - 165 .

Salerno JA, Previtali M, Panciroli C, Klersy C, Chimienti M, Regazzi Bonora M, Marangoni E, Falcone C et al. ( 1986 ) . Ventricular arrhythmias during acute myocardial ischaemia in man. The role and significance of R-ST-T alternans and the prevention of ischaemic sudden death by medical treatment . Eur Heart J vol. 7 Suppl A , 63 - 75 .