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Research

Publications: Prof Maurice Elphick

Yañez-Guerra LA, Zhong X, Moghul I, Butts T, Zampronio CG, Jones AM, Mirabeau O, Elphick MR ( 2020 ) . Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling . eLife vol. 9 ,
Odekunle EA, Elphick MR ( 2020 ) . Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates . Frontiers in Endocrinology vol. 11 ,
Yanez-Guerra L, Elphick M ( 2020 ) . Evolution and comparative physiology of luqin-type neuropeptide signalling . Frontiers in Neuroscience
Sobrido-Cameán D, Yáñez-Guerra LA, Robledo D, López-Varela E, Rodicio MC, Elphick MR, Anadón R, Barreiro-Iglesias A ( 2019 ) . Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems . Brain Structure and Function
Mita M, Elphick M, Katayama H ( 2019 ) . Effect of chimeric relaxin-like gonad-stimulating peptides on oocyte maturation and ovulation in the starfish Asterias rubens and Aphelasterias japonica . General and Comparative Endocrinology
Peacey L, Elphick MR, Jones CE ( 2019 ) . Roles of copper in neurokinin B and gonadotropin-releasing hormone structure and function and the endocrinology of reproduction . General and Comparative Endocrinology113342 - 113342 .
Satake H, Larhammar D, Elphick MR ( 2019 ) . Editorial: Endocrine and Neuroendocrine Systems of Invertebrate Deuterostomes . Frontiers in Endocrinology vol. 10 ,
Sobrido-Cameán D, Yáñez-Guerra LA, Lamanna F, Conde-Fernández C, Kaessmann H, Elphick MR, Anadón R, Rodicio MC et al. ( 2019 ) . Galanin in an Agnathan: Precursor Identification and Localisation of Expression in the Brain of the Sea Lamprey Petromyzon marinus . Frontiers in Neuroanatomy vol. 13 ,
ODEKUNLE EA, SEMMENS DC, Martynyuk N, Tinoco AB, Garewal AK, Patel RR, BLOWES LM, Zandawala M et al. ( 2019 ) . Ancient role of vasopressin/oxytocin-type neuropeptides as regulators of feeding revealed in an echinoderm . BMC Biology vol. 17 , ( 1 ) Article 60 ,
Chen M, Talarovicova A, Zheng Y, Storey KB, Elphick MR ( 2019 ) . Neuropeptide precursors and neuropeptides in the sea cucumber Apostichopus japonicus: a genomic, transcriptomic and proteomic analysis . Scientific Reports vol. 9 , ( 1 ) Article 8829 ,
Philippe H, Poustka AJ, Chiodin M, Hoff KJ, Dessimoz C, Tomiczek B, Schiffer PH, Müller S et al. ( 2019 ) . Mitigating Anticipated Effects of Systematic Errors Supports Sister-Group Relationship between Xenacoelomorpha and Ambulacraria . Current Biology vol. 29 , ( 11 ) 1818 - 1826.e6 .
Byrne M, Mazzone F, Elphick MR, Thorndyke MC, Cisternas P ( 2019 ) . Expression of the neuropeptide SALMFamide-1 during regeneration of the seastar radial nerve cord following arm autotomy . Proc Biol Sci vol. 286 , ( 1901 ) 20182701 - 20182701 .
Tran KK, Jayawardena BM, Elphick MR, Jones CE ( 2018 ) . A gonadotropin-releasing hormone type neuropeptide with a high affinity binding site for copper(ii) and nickel(ii) . Metallomics
Wood NJ, Mattiello T, Rowe ML, Ward L, Perillo M, Arnone MI, Elphick MR, Oliveri P ( 2018 ) . Neuropeptidergic Systems in Pluteus Larvae of the Sea Urchin Strongylocentrotus purpuratus: Neurochemical Complexity in a "Simple" Nervous System . FRONTIERS IN ENDOCRINOLOGY vol. 9 , Article ARTN 628 ,
Elphick MR, Mirabeau O, Larhammar D ( 2018 ) . Correction: Evolution of neuropeptide signalling systems (doi:10.1242/jeb.151092) . J Exp Biol vol. 221 , ( Pt 19 )
Tinoco AB, Semmens DC, Patching EC, Gunner EF, Egertová M, Elphick MR ( 2018 ) . Characterization of NGFFYamide signaling in starfish reveals roles in regulation of feeding behavior and locomotory systems . Frontiers in Endocrinology vol. 9 , ( SEP )
Cai W, Kim CH, Go HJ, Egertová M, Zampronio CG, Jones AM, Park NG, Elphick MR ( 2018 ) . Biochemical, anatomical, and pharmacological characterization of Calcitonin-type neuropeptides in Starfish: Discovery of an ancient role as muscle relaxants . Frontiers in Neuroscience vol. 12 , ( JUN )
Yañez-Guerra LA, DELROISSE J, Barreiro-Iglesias A, Slade S, Scrivens J, ELPHICK MR ( 2018 ) . Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome . Scientific Reports
Kim C-H, Go H-J, Oh HY, Park JB, Lee TK, Seo J-K, ELPHICK MR, Park NG ( 2018 ) . Identification of a novel antimicrobial peptide from the sea star Patiria pectinifera . Developmental & Comparative Immunology
Kim C-H, Go H-J, Oh HY, ELPHICK MR, Park NG ( 2018 ) . Identification of evolutionarily conserved residues required for the bioactivity of a pedal peptide/orcokinin-type neuropeptide . Peptides
Dylus D, Czarkwiani A, BLOWES L, ELPHICK MR, Oliveri P ( 2018 ) . Developmental transcriptomics of the brittle star Amphiura filiformis reveals gene regulatory network rewiring in echinoderm larval skeleton evolution . Genome Biology vol. 19 ,
ELPHICK MR, Mirabeau O, Larhammar D ( 2018 ) . Evolution of neuropeptide signalling systems . Journal of Experimental Biology
Gupta HS, Szulgit G, Elphick MR, Mo J ( 2018 ) . Unlocking the secrets of mutable collagenous tissue . Biochemist vol. 40 , ( 1 ) 8 - 11 .
Li L, Su S, Perry CJ, Elphick MR, Chittka L, Søvik E ( 2018 ) . Large-scale transcriptome changes in the process of long-term visual memory formation in the bumblebee, Bombus terrestris . Sci Rep vol. 8 , ( 1 ) 534 - 534 .
LIN M, EGERTOVA M, Zampronio C, Jones A, ELPHICK MR ( 2017 ) . Functional characterization of a second pedal peptide/orcokinin-type neuropeptide signaling system in the starfish Asterias rubens . Journal of Comparative Neurology
Suwansa-Ard S, Chaiyamoon A, Talarovicova A, Tinikul R, Tinikul Y, Poomtong T, Elphick MR, Cummins SF et al. ( 2017 ) . Transcriptomic discovery and comparative analysis of neuropeptide precursors in sea cucumbers (Holothuroidea) . Peptides
Li L, MaBouDi HD, Egertová M, Elphick MR, Chittka L, Perry CJ ( 2017 ) . A possible structural correlate of learning performance on a colour discrimination task in the brain of the bumblebee . Proceedings of the Royal Society B: Biological Sciences vol. 284 , ( 1864 )
Tian S, Egertova M, Elphick MR ( 2017 ) . Functional Characterization of Paralogous Gonadotropin-Releasing Hormone-Type and Corazonin-Type Neuropeptides in an Echinoderm . Frontiers in Endocrinology vol. 8 , Article 259 , 1 - 24 .
Kim CH, Go HJ, Oh HY, Jo YH, Elphick MR, Park NG ( 2017 ) . Transcriptomics reveals tissue/organ-specific differences in gene expression in the starfish Patiria pectinifera . Marine Genomics
Zandawala M, Moghul I, Yanez Guerra LA, Delroisse J, Abylkassimova N, Hugall AF, O'Hara TD, Elphick MR ( 2017 ) . Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms . Open Biology vol. 7 , Article 170129 , 1 - 20 .
Lin M, Egertová M, Zampronio CG, Jones AM, Elphick MR ( 2017 ) . Pedal peptide/orcokinin-type neuropeptide signaling in a deuterostome: The anatomy and pharmacology of starfish myorelaxant peptide in Asterias rubens . Journal of Comparative Neurology
Blowes LM, Egertova M, Liu Y, Davis GR, Terrill NJ, Gupta HS, ELPHICK MR ( 2017 ) . Body wall structure in the starfish Asterias rubens . Journal of Anatomy Article JOA12646 ,
ELPHICK MR, Tian S, Zandawala M ( 2017 ) . The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems . General and Comparative Endocrinology
Smith MK, Wang T, Suwansa-Ard S, Motti CA, Elizur A, Zhao M, Rowe ML, Hall MR et al. ( 2017 ) . The neuropeptidome of the Crown-of-Thorns Starfish, Acanthaster planci . J Proteomics
ELPHICK MR, Semmens ( 2017 ) . The evolution of neuropeptide signalling: insights from echinoderms . Briefings in Functional Genomics
Mayorova TD, Tian S, Cai W, Semmens DC, Odekunle EA, Zandawala M, Badi Y, Rowe ML et al. ( 2016 ) . Localization of Neuropeptide Gene Expression in Larvae of an Echinoderm, the Starfish Asterias rubens . Front Neurosci vol. 10 , 553 - 553 .
Lin M, Mita M, Egertová M, Zampronio CG, Jones AM, Elphick MR ( 2016 ) . Cellular localization of relaxin-like gonad-stimulating peptide expression in Asterias rubens: New insights into neurohormonal control of spawning in starfish . J Comp Neurol
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR, Gupta HS ( 2016 ) . Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale . Proc Natl Acad Sci U S A
Tian S, Zandawala M, Beets I, Baytemur E, Slade SE, Scrivens JH, ELPHICK MR ( 2016 ) . Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways . Scientific Reports vol. 6 , Article 28788 ,
Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M et al. ( 2016 ) . Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus . Brain Structure and Function vol. 221 , ( 4 ) 2061 - 2074 .
Kim CH, Kim EJ, Go HJ, Oh HY, Lin M, Elphick MR, Park NG ( 2016 ) . Identification of a novel starfish neuropeptide that acts as a muscle relaxant . Journal of Neurochemistry vol. 137 , ( 1 ) 33 - 45 .
Semmens DC, Mirabeau O, Moghul I, Pancholi MR, Wurm Y, Elphick MR ( 2016 ) . Transcriptomic identification of Starfish Neuropeptide precursors yields new insights into neuropeptide evolution . Open Biology vol. 6 , ( 2 )
Jones CE, Zandawala M, Semmens DC, Anderson S, Hanson GR, Janies DA, Elphick MR ( 2016 ) . Identification of a neuropeptide precursor protein that gives rise to a "cocktail" of peptides that bind Cu(II) and generate metal-linked dimers . Biochimica et Biophysica Acta - General Subjects vol. 1860 , ( 1 ) 57 - 66 .
D'Aniello S, Delroisse J, Valero-Gracia A, Lowe EK, Byrne M, Cannon JT, Halanych KM, Elphick MR et al. ( 2015 ) . Opsin evolution in the Ambulacraria . Marine Genomics vol. 24 , 177 - 183 .
Christensen AB, Herman JL, Elphick MR, Kober KM, Janies D, Linchangco G, Semmens DC, Bailly X et al. ( 2015 ) . Phylogeny of echinoderm hemoglobins . PLoS ONE vol. 10 , ( 8 )
D'Aniello S, Delroisse J, Valero-Gracia A, Lowe EK, Byrne M, Cannon JT, Halanych KM, Elphick MR et al. ( 2015 ) . Opsin evolution in the Ambulacraria . Marine Genomics
Semmens DC, Beets I, Rowe ML, Blowes LM, Oliveri P, Elphick MR ( 2015 ) . Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family . Open Biology vol. 5 , ( 4 )
Smith TH, Blume LC, Straiker A, Cox JO, David BG, Secor McVoy JR, Sayers KW, Poklis JL et al. ( 2015 ) . Cannabinoid receptor-interacting protein 1a modulates CB<inf>1</inf> receptor signaling and regulation . Molecular Pharmacology vol. 87 , ( 4 ) 747 - 765 .
Elphick MR, Semmens DC, Blowes LM, Levine J, Lowe CJ, Arnone MI, Clark MS ( 2015 ) . Reconstructing SALMFamide Neuropeptide Precursor Evolution in the Phylum Echinodermata: Ophiuroid and Crinoid Sequence Data Provide New Insights . Front Endocrinol (Lausanne) vol. 6 ,
Jones CE, Otara CB, Younan ND, Viles JH, Elphick MR ( 2014 ) . Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2 . Biochim Biophys Acta vol. 1844 , ( 10 ) 1842 - 1850 .
Elphick MR ( 2014 ) . SALMFamide salmagundi: the biology of a neuropeptide family in echinoderms . Gen Comp Endocrinol vol. 205 , 23 - 35 .
Rowe ML, Achhala S, Elphick MR ( 2014 ) . Neuropeptides and polypeptide hormones in echinoderms: new insights from analysis of the transcriptome of the sea cucumber Apostichopus japonicus . Gen Comp Endocrinol vol. 197 , 43 - 55 .
Otara CB, Jones CE, Younan ND, Viles JH, Elphick MR ( 2014 ) . Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: the N-terminal region of S2 facilitates self-association . Biochim Biophys Acta vol. 1844 , ( 2 ) 358 - 365 .
Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, Laferla FM, Vendemiale G et al. ( 2014 ) . Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease . J Alzheimers Dis vol. 40 , ( 3 ) 701 - 712 .
Elphick MR, Mirabeau O ( 2014 ) . The Evolution and Variety of RFamide-Type Neuropeptides: Insights from Deuterostomian Invertebrates . Front Endocrinol (Lausanne) vol. 5 ,
Semmens DC, Dane RE, Pancholi MR, Slade SE, Scrivens JH, Elphick MR ( 2013 ) . Discovery of a novel neurophysin-associated neuropeptide that triggers cardiac stomach contraction and retraction in starfish . J Exp Biol vol. 216 , ( Pt 21 ) 4047 - 4053 .
Elphick MR ( 2013 ) . From gonadotropin-inhibitory hormone to SIFamides: are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes? . Gen Comp Endocrinol vol. 193 , 229 - 233 .
ELPHICK MR, Achhala S, Martynyuk N ( 2013 ) . The evolution and diversity of SALMFamide neuropeptides . PLoS One vol. 8 , ( 3 )
Elphick MR ( 2012 ) . The evolution and comparative neurobiology of endocannabinoid signalling . Philos Trans R Soc Lond B Biol Sci vol. 367 , ( 1607 ) 3201 - 3215 .
Rowe ML, Elphick MR ( 2012 ) . The neuropeptide transcriptome of a model echinoderm, the sea urchin Strongylocentrotus purpuratus . Gen Comp Endocrinol vol. 179 , ( 3 ) 331 - 344 .
Schneider M, Elphick MR ( 2012 ) . Neuropharmacology of cannabinoids . Encyclopedia of Addictive Behaviours , Editors: Miller, PM , Academic Press
Elphick MR ( 2012 ) . The protein precursors of peptides that affect the mechanics of connective tissue and/or muscle in the echinoderm Apostichopus japonicus . PLoS One vol. 7 , ( 8 )
Stauffer B, Wallis KT, Wilson SP, Egertova M, Elphick MR, Lewis DL, Hardy LR ( 2011 ) . CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity . NEUROSCI LETT vol. 503 , ( 3 ) 224 - 228 .
Pertwee RG, Howlett AC, Abood ME, Alexander SPH, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS et al. ( 2010 ) . International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 . PHARMACOL REV vol. 62 , ( 4 ) 588 - 631 .
Elphick MR ( 2010 ) . NG peptides: a novel family of neurophysin-associated neuropeptides . Gene vol. 458 , ( 1-2 ) 20 - 26 .
Rowe ML, Elphick MR ( 2010 ) . Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm species . MAR GENOM vol. 3 , ( 2 ) 91 - 97 .
Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ ( 2009 ) . Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy . NEUROPHARMACOLOGY vol. 57 , ( 3 ) 208 - 218 .
Guasti L, Richardson D, Jhaveri M, Eldeeb K, Barrett D, Elphick MR, Alexander SPH, Kendall D et al. ( 2009 ) . Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain . Mol Pain vol. 5 ,
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M et al. ( 2009 ) . MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family . Proc Natl Acad Sci U S A vol. 106 , ( 15 ) 6146 - 6151 .
Hardt TA, Elphick M, Lewis DL, Selley DE ( 2009 ) . Cannabinoid Receptor Interacting Protein (CRIP1a) attenuates CB1 signalling . FASEB JOURNAL vol. 23 ,
Elphick MR, Rowe ML ( 2009 ) . NGFFFamide and echinotocin: structurally unrelated myoactive neuropeptides derived from neurophysin-containing precursors in sea urchins . J Exp Biol vol. 212 , ( Pt 8 ) 1067 - 1077 .
Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF et al. ( 2009 ) . Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury . J NEUROSCI vol. 29 , ( 12 ) 3766 - 3780 .
Cooray SN, Almiro Do Vale I, Leung K-Y, Webb TR, Chapple JP, Egertová M, Cheetham ME, Elphick MR et al. ( 2008 ) . The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line . Endocrinology vol. 149 , ( 4 ) 1935 - 1941 .
Egertová M, Simon GM, Cravatt BF, Elphick MR ( 2008 ) . Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules . J Comp Neurol vol. 506 , ( 4 ) 604 - 615 .
Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H et al. ( 2007 ) . CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a . Mol Pharmacol vol. 72 , ( 6 ) 1557 - 1566 .
Elphick MR ( 2007 ) . BfCBR: A cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus) . GENE vol. 399 , ( 1 ) 65 - 71 .
Yun SS, Thorndyke MC, Elphick MR ( 2007 ) . Identification of novel SALMFamide neuropeptides in the starfish Marthasterias glacialis . COMP BIOCHEM PHYS A vol. 147 , ( 2 ) 536 - 542 .
Egertova M, Elphick MR ( 2007 ) . Localization of CiCBR in the invertebrate chordate Ciona intestinalis: Evidence of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling . J COMP NEUROL vol. 502 , ( 4 ) 660 - 672 .
Ott SR, Aonuma H, Newland PL, Elphick MR ( 2007 ) . Nitric oxide synthase in crayfish walking leg ganglia: Segmental differences in chemo-tactile centers argue against a generic role in sensory integration . J COMP NEUROL vol. 501 , ( 3 ) 381 - 399 .
Ott SR, Philippides A, Elphick MR, O'Shea M ( 2007 ) . Enhanced fidelity of diffusive nitric oxide signalling by the spatial segregation of source and target neurones in the memory centre of an insect brain . Eur J Neurosci vol. 25 , ( 1 ) 181 - 190 .
Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X et al. ( 2006 ) . A genomic view of the sea urchin nervous system . DEV BIOL vol. 300 , ( 1 ) 434 - 460 .
Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Weinstock GM, Angerer RC, Angerer LM et al. ( 2006 ) . Research article - The genome of the sea urchin Strongylocentrotus purpuratus . SCIENCE vol. 314 , ( 5801 ) 941 - 952 .
Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI et al. ( 2006 ) . The genome of the sea urchin Strongylocentrotus purpuratus . Science vol. 314 , ( 5801 ) 941 - 952 .
Monory K, Massa F, Egertova M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W et al. ( 2006 ) . The endocannabinoid system controls key epileptogenic circuits in the hippocampus . NEURON vol. 51 , ( 4 ) 455 - 466 .
Elphick MR, Thorndyke MC ( 2005 ) . Molecular characterisation of SALMFamide neuropeptides in sea urchins . J Exp Biol vol. 208 , ( Pt 22 ) 4273 - 4282 .
Elphick MR ( 2005 ) . Neuropeptide structure and function in echinoderms . COMP BIOCHEM PHYS A vol. 141 , ( 3 ) S160 - S161 .
Otara CB, Jones CE, Melarange R, Viles JH, Elphick MR ( 2005 ) . Tertiary structure and activity of SALMFamide neuropeptides . COMP BIOCHEM PHYS A vol. 141 , ( 3 ) S161 - S161 .
Kurylas AE, Ott SR, Schachtner J, ELPHICK MR, Williams L, Homberg U ( 2005 ) . Localization of nitric oxide synthase in the central complex and surrounding midbrain neuropils of the locust Schistocerca gregaria . J. Comp. Neurol vol. 484 , ( 2 ) 206 - 223 .
Elphick MR, Egertová M ( 2005 ) . The phylogenetic distribution and evolutionary origins of endocannabinoid signalling . Handb Exp Pharmacol ( 168 ) 283 - 297 .
Egertová M, Michael GJ, Cravatt BF, Elphick MR ( 2004 ) . Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat . J Chem Neuroanat vol. 28 , ( 3 ) 171 - 181 .
Ott SR, Delago A, Elphick MR ( 2004 ) . An evolutionarily conserved mechanism for sensitization of soluble guanylyl cyclase reveals extensive nitric oxide-mediated upregulation of cyclic GMP in insect brain . Eur J Neurosci vol. 20 , ( 5 ) 1231 - 1244 .
Ott SR, Elphick MR ( 2003 ) . New techniques for whole-mount NADPH-diaphorase histochemistry demonstrated in insect ganglia . J Histochem Cytochem vol. 51 , ( 4 ) 523 - 532 .
Melarange R, Elphick MR ( 2003 ) . Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish . J EXP BIOL vol. 206 , ( 5 ) 893 - 899 .
Elphick MR, Satou Y, Satoh N ( 2003 ) . The invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate Ciona intestinalis . GENE vol. 302 , ( 1-2 ) 95 - 101 .
Egertova M, Cravatt BF, Elphick MR ( 2003 ) . Comparative analysis of fatty acid amide hydrolase and CB1 cannabinoid receptor expression in the mouse brain: Evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling . NEUROSCIENCE vol. 119 , ( 2 ) 481 - 496 .
Bridges D, Rice ASC, Egertova M, Elphick MR, Winter J, Michael GJ ( 2003 ) . Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry . NEUROSCIENCE . vol. 119 , 803 - 812 .
Ott SR, Elphick MR ( 2002 ) . Nitric oxide synthase histochemistry in insect nervous systems: Methanol/formalin fixation reveals the neuroarchitecture of formaldehyde-sensitive NADPH diaphorase in the cockroach Periplaneta americana . J Comp Neurol vol. 448 , ( 2 ) 165 - 185 .
Elphick MR ( 2002 ) . Evolution of cannabinoid receptors in vertebrates: Identification of a CB2 gene in the puffer fish Fugu rubripes . BIOL BULL vol. 202 , ( 2 ) 104 - 107 .
Elphick MR, Melarange R ( 2001 ) . Neural control of muscle relaxation in echinoderms . Journal of Experimental Biology vol. 204 , ( 5 ) 875 - 885 .
Ott SR, Burrows M, Elphick MR ( 2001 ) . The neuroanatomy of nitric oxide-cyclic GMP signaling in the locust: Functional implications for sensory systems . AMERICAN ZOOLOGIST . vol. 41 , 321 - 331 .
Elphick MR, Egertová M ( 2001 ) . The neurobiology and evolution of cannabinoid signalling . Philos Trans R Soc Lond B Biol Sci vol. 356 , ( 1407 ) 381 - 408 .
Elphick MR, Melarange R ( 2001 ) . Neural control of muscle relaxation in echinoderms . J Exp Biol vol. 204 , ( Pt 5 ) 875 - 885 .
Ott SR, Jones IW, Burrows M, Elphick MR ( 2000 ) . Sensory afferents and motor neurons as targets for nitric oxide in the locust . Journal of Comparative Neurology vol. 422 , ( 4 ) 521 - 532 .
Egertová M, Elphick MR ( 2000 ) . Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB . J Comp Neurol vol. 422 , ( 2 ) 159 - 171 .
Egertová M, Elphick MR ( 2000 ) . Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB<inf>1</inf> . Journal of Comparative Neurology vol. 422 , ( 2 ) 159 - 171 .
Egertová M, Cravatt BF, Elphick MR ( 2000 ) . Fatty acid amide hydrolase expression in rat choroid plexus: Possible role in regulation of the sleep-inducing action of oleamide . Neuroscience Letters vol. 282 , ( 1-2 ) 13 - 16 .
Farquhar-Smith WP, Egertová M, Bradbury EJ, McMahon SB, Rice ASC, Elphick MR ( 2000 ) . Cannabinoid CB<inf>1</inf> receptor expression in rat spinal cord . Molecular and Cellular Neurosciences vol. 15 , ( 6 ) 510 - 521 .
Melarange R, Potton DJ, Thorndyke MC, Elphick MR ( 1999 ) . SALMFamide neuropeptides cause relaxation and eversion of the cardiac stomach in starfish . Proceedings of the Royal Society B: Biological Sciences vol. 266 , ( 1430 ) 1785 - 1789 .
Jones IW, Elphick MR ( 1999 ) . Dark-dependent soluble guanylyl cyclase activity in locust photoreceptor cells . Proceedings of the Royal Society B: Biological Sciences vol. 266 , ( 1417 ) 413 - 419 .
Egertova M, Giang DK, Cravatt BF, Elphick MR ( 1998 ) . A new perspective on cannabinoid signalling: Complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain . Proceedings of the Royal Society B: Biological Sciences vol. 265 , ( 1410 ) 2081 - 2085 .
Elphick MR, Jones IW ( 1998 ) . Localization of soluble guanylyl cyclase α-subunit in identified insect neurons . Brain Research vol. 800 , ( 1 ) 174 - 179 .
Elphick MR ( 1998 ) . An invertebrate G-protein coupled receptor is a chimeric cannabinoid/melanocortin receptor . Brain Research vol. 780 , ( 1 ) 170 - 173 .
Elphick MR, Melarange R ( 1998 ) . Nitric oxide function in an echinoderm . Biological Bulletin vol. 194 , ( 3 ) 260 - 266 .
Elphick MR, Schleiffer R ( 1997 ) . Comparative physiology of the L-arginine-nitric oxide pathway: An overview of a symposium at the 4th International Congress of Comparative Physiology and Biochemistry, 1995 . Comparative Biochemistry and Physiology - A Physiology vol. 118 , ( 4 ) 921 - 923 .
Elphick MR ( 1997 ) . Localization of nitric oxide synthase using NADPH diaphorase histochemistry . Methods in molecular biology (Clifton, N.J.) vol. 72 , 153 - 158 .
Elphick MR, Williams L, O'Shea M ( 1996 ) . New features of the locust optic lobe: Evidence of a role for nitric oxide in insect vision . Journal of Experimental Biology vol. 199 , ( 11 ) 2395 - 2407 .
Elphick M, Williams L, Shea M ( 1996 ) . New features of the locust optic lobe: evidence of a role for nitric oxide in insect vision . J Exp Biol vol. 199 , ( Pt 11 ) 2395 - 2407 .
Elphick MR, Newman SJ, Thorndyke MC ( 1995 ) . Distribution and action of SALMFamide neuropeptides in the starfish Asterias rubens . J Exp Biol vol. 198 , ( Pt 12 ) 2519 - 2525 .
Elphick MR, Newman SJ, Thorndyke MC ( 1995 ) . Distribution and action of SLAMFamide neuropeptides in the starfish Asterias rubens . Journal of Experimental Biology vol. 198 , ( 12 ) 2519 - 2525 .
Elphick MR, Kemenes G, Staras K, O'Shea M ( 1995 ) . Behavioral role for nitric oxide in chemosensory activation of feeding in a mollusc . Journal of Neuroscience vol. 15 , ( 11 ) 7653 - 7664 .
Elphick M, Rayne R, Riveros-Moreno V, Moncada S, Shea M ( 1995 ) . Nitric oxide synthesis in locust olfactory interneurones . J Exp Biol vol. 198 , ( Pt 3 ) 821 - 829 .
Newman SJ, Elphick MR, Thorndyke MC ( 1995 ) . Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish Asterias rubens using novel monoclonal and polyclonal antibodies. II. Digestive system . Proceedings of the Royal Society B: Biological Sciences vol. 261 , ( 1361 ) 187 - 192 .
Newman SJ, Elphick MR, Thorndyke MC ( 1995 ) . Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish asterias rubens using novel monoclonal and polyclonal antibodies. I. Nervous and locomotory systems . Proceedings of the Royal Society B: Biological Sciences vol. 261 , ( 1360 ) 139 - 145 .
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