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  1. Queen Mary University of London
  2. Research
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Publications: Dr Fabian Flores-Borja

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Graham R, Gazinska P, Zhang B, Khiabany A, Sinha S, Alaguthurai T, Flores-Borja F, Vicencio J et al. ( 2023 ) . Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes . Frontiers in Immunology vol. 14 ,
Barber PR, Mustapha R, Flores-Borja F, Alfano G, Ng K, Weitsman G, Dolcetti L, Mohamed AA et al. ( 2022 ) . Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development . eLife vol. 11 ,
Soria-Castro R, Meneses-Preza YG, Rodríguez-López GM, Ibarra-Sánchez A, González-Espinosa C, Pérez-Tapia SM, Flores-Borja F, Estrada-Parra S et al. ( 2022 ) . Valproic acid restricts mast cell activation by Listeria monocytogenes . Scientific Reports vol. 12 , ( 1 )
Flores-Borja F, Blair P ( 2022 ) . Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses . Clinical & Experimental Immunology vol. 209 , ( 1 ) 33 - 45 .
Vicencio JM, Evans R, Green R, An Z, Deng J, Treacy C, Mustapha R, Monypenny J et al. ( 2022 ) . Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans . Cell Death & Disease vol. 13 , ( 3 )
Parkinson EK, Adamski J, Zahn G, Gaumann A, Flores-Borja F, Ziegler C, Mycielska ME ( 2021 ) . Extracellular citrate and metabolic adaptations of cancer cells . Cancer and Metastasis Reviews vol. 40 , ( 4 ) 1073 - 1091 .
Soria-Castro R, Chávez-Blanco AD, García-Pérez BE, Wong-Baeza I, Flores-Mejía R, Flores-Borja F, Estrada-Parra S, Estrada-García I et al. ( 2020 ) . Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection . Scientific Reports vol. 10 , ( 1 )
Gómez V, Eykyn TR, Mustapha R, Flores-Borja F, Male V, Barber PR, Patsialou A, Green R et al. ( 2020 ) . Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells . Science Signaling vol. 13 , ( 652 )
Rodríguez-López GM, Soria-Castro R, Campillo-Navarro M, Pérez-Tapia SM, Flores-Borja F, Wong-Baeza I, Muñoz-Cruz S, López-Santiago R et al. ( 2020 ) . The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE-mediated mast cell activation . Journal of Leukocyte Biology
An Z, Flores-Borja F, Irshad S, Deng J, Ng T ( 2020 ) . Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer . Frontiers in Immunology vol. 10 ,
Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C et al. ( 2019 ) . Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer . Cell Reports vol. 27 , ( 7 ) 1967 - 1978.e4 .
Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A et al. ( 2018 ) . ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation . Cell Reports vol. 24 , ( 3 ) 630 - 641 .
Ng T, Flores-Borja F, Alfano G, Barber P, Weitsman G, Wong F ( 2018 ) . The use of exosome and immune profiling to analyze a phase 2 study on the addition of patritumab or placebo to cetuximab and a platinum agent for recurrent / metastatic head and neck cancer (R/M HNSCC) patients . JOURNAL OF CLINICAL ONCOLOGY . Conference: 2018 American Society of Clinical Oncology vol. 36 ,
Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ et al. ( 2017 ) . Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment . Theranostics vol. 7 , ( 9 ) 2392 - 2401 .
Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, Gordon P, Cheung A et al. ( 2017 ) . RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers . Cancer Res vol. 77 , ( 5 ) 1083 - 1096 .
Flores-Borja F, Irshad S, Gordon P, Wong F, Sheriff I, Tutt A, Ng T ( 2016 ) . Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment . Journal of Immunology Research vol. 2016 , ( 1 )
Becker A, Hokamp NG, Zenker S, Flores-Borja F, Barzcyk K, Varga G, Roth J, Geyer C et al. ( 2015 ) . Optical In Vivo Imaging of the Alarmin S100A9 in Tumor Lesions Allows for Estimation of the Individual Malignant Potential by Evaluation of Tumor–Host Cell Interaction . Journal of Nuclear Medicine vol. 56 , ( 3 ) 450 - 456 .
Irshad S, Lawler K, Flores-Borja F, Monypenny J, Evans R, Grigoriadis A, Fruhwirth G, Cheung A et al. ( 2014 ) . Effect of lymphoid tissue inducer cells on lymphatic tumor cell invasion via activation of the RANKL/RANK axis within triple-negative breast cancers . Journal of Clinical Oncology . vol. 32 , 11082 - 11082 .
Irshad S, Lawler K, Evans R, Flores-Borja F, Monypenny J, Grigoriadis A, Fruhwith G, Poland S et al. ( 2013 ) . Abstract P5-01-01: Lymphoid tissue inducer cells: Identification of a novel immune cell within the breast tumour microenvironment and its role in promoting tumour cell invasion . Cancer Research . vol. 73 ,
Taher TE, Muhammad HA, Bariller E, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA ( 2013 ) . B-Lymphocyte Signalling Abnormalities and Lupus Immunopathology . International Reviews of Immunology vol. 32 , ( 4 ) 428 - 444 .
Taher TE, Muhammad HA, Rahim A, Flores‐Borja F, Renaudineau Y, Isenberg DA, Mageed RA ( 2013 ) . Aberrant B‐lymphocyte responses in lupus: inherent or induced and potential therapeutic targets . European Journal of Clinical Investigation vol. 43 , ( 8 ) 866 - 880 .
Irshad S, Flores-Borja FF, Evans R, Fruhwirth G, Pitmilly JM, Poland S, Ameer-Beg S, Tutt A et al. ( 2013 ) . 89O Use of Live In-Vivo Lymphatic Imaging Techniques to Study the Effects of Immune Cell Interactions in a Syngeneic Mouse Model of Breast Cancer . Annals of Oncology vol. 24 ,
Flores-Borja F, Bosma A, Ng D, Reddy V, Ehrenstein MR, Isenberg DA, Mauri C ( 2013 ) . CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation . Science Translational Medicine vol. 5 , ( 173 )
Taher TE, Parikh K, Flores‐Borja F, Mletzko S, Isenberg DA, Peppelenbosch MP, Mageed RA ( 2010 ) . Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus . Arthritis & Rheumatism vol. 62 , ( 8 ) 2412 - 2423 .
Jury EC, Flores‐Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR ( 2010 ) . Abnormal CTLA‐4 function in T cells from patients with systemic lupus erythematosus . European Journal of Immunology vol. 40 , ( 2 ) 569 - 578 .
Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C ( 2010 ) . CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients . Immunity vol. 32 , ( 1 ) 129 - 140 .
Mauri C, Carter NA, Flores-Borja F, Blair PA ( 2010 ) . More than T regs, the relevance of other lymphocytes . IMMUNOLOGY . vol. 131 , 18 - 18 .
Flores-Borja F, Cambridge G, Ng D, Turi M, Ehrenstein MR, Isenberg D, Mauri C ( 2010 ) . Regulatory B cells prevent the differentiation of naive CD4<SUP>+</SUP>T-cells into TH1 and TH17 but favour FOXP3+Tregs development . IMMUNOLOGY . vol. 131 , 62 - 63 .
Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR ( 2008 ) . Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis . Proceedings of the National Academy of Sciences of the United States of America vol. 105 , ( 49 ) 19396 - 19401 .
Flores‐Borja F, Mauri C, Ehrenstein MR ( 2008 ) . Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis . European Journal of Immunology vol. 38 , ( 4 ) 934 - 937 .
Jury EC, Flores-Borja F, Isenberg DA, Mauri C, Ehrenstein MR ( 2008 ) . Abnormal CTLA-4 function in lupus patients is associated with induction of a defective population of FOXP3+regulatory T cells via TGF . RHEUMATOLOGY . vol. 47 , II64 - II64 .
Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR ( 2008 ) . Abnormal cytotoxic T lymphocyte antigen-4 function in lupus patients is associated with induction of defective Foxp3+Treg . IMMUNOLOGY . vol. 125 , 38 - 38 .
Flores-Borja F, Jury EC, Ehrenstein MR ( 2008 ) . Defective CTLA-4 function in regulatory T cells from patients with rheumatoid arthritis: A potential target for therapy . RHEUMATOLOGY . vol. 47 , II55 - II55 .
Jury EC, Flores-Borja F, Kabouridis PS ( 2007 ) . Lipid rafts in T cell signalling and disease . SEMIN CELL DEV BIOL vol. 18 , ( 5 ) 608 - 615 .
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA ( 2007 ) . Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus . Arthritis Rheum vol. 56 , ( 1 ) 291 - 302 .
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA ( 2006 ) . Lyn deficiency in B cells from patients with systemic lupus erythematosus: comment on the article by Flores-Borja et al - Reply . ARTHRITIS RHEUM vol. 54 , ( 6 ) 2037 - 2038 .
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA ( 2005 ) . Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus . Arthritis Rheum vol. 52 , ( 12 ) 3955 - 3965 .
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA ( 2005 ) . Translocation of CD45 to lipid raft signalling domains and abnormal relocation during B-lymphocyte activation in SLE . RHEUMATOLOGY . vol. 44 , I17 - I17 .
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA ( 2004 ) . Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus . Journal of Clinical Investigation vol. 113 , ( 8 ) 1176 - 1187 .
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA ( 2004 ) . Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus . J CLIN INVEST vol. 113 , ( 8 ) 1176 - 1187 .
Flores-Borja F, Kieszkievicz J, Church V, Francis-West PH, Schofield J, Rademacher TW, Lund T ( 2004 ) . Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D . Biochimie vol. 86 , ( 4-5 ) 275 - 282 .
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA ( 2004 ) . ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) . RHEUMATOLOGY . vol. 43 , 24 - 24 .
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA ( 2004 ) . ATYPICAL CO-LOCALISATION OF CD45 AND LYN TO LIPID RAFT SIGNALLING DOMAINS CORRELATES WITH B-LYMPHOCYTE HYPER RESPONSIVENESS IN PATIENTS WITH LUPUS . RHEUMATOLOGY . vol. 43 , 108 - 108 .
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA ( 2003 ) . Abnormal co-localisation of CD45 and lipid rafts is associated with reduced LCK expression in T cells from patients with SLE . ARTHRITIS AND RHEUMATISM . vol. 48 , S193 - S193 .
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA ( 2003 ) . ANALYSIS OF LIPID RAFT-ASSOCIATED SIGNALLING MOLECULES IN B CELLS FROM NORMAL AND PATIENTS WITH SLE . RHEUMATOLOGY . vol. 42 , 72 - 73 .
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA ( 2003 ) . CD45 IS ABNORMALLY ASSOCIATED WITH LIPID RAFTS IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) . RHEUMATOLOGY . vol. 42 , 5 - 5 .
Monroy-Garcı́a A, Ortı́z-Navarrete VF, de Lourdes Mora-Garcı́a M, Flores-Borja F, Diaz-Quiñonez A, Isibasi-Araujo A, Trejo-Becerril C, Chacón-Salinas R et al. ( 1999 ) . Identification of peptides presented by HLA class I molecules on cervical cancer cells with HPV-18 infection . Immunology Letters vol. 67 , ( 3 ) 167 - 177 .
Flores-Borja F, Santiago E, Weiss-Steider B ( 1998 ) . Fc gamma receptors in health and disease . Revista de Investigación Clínica vol. 50 , ( 6 ) 529 - 540 .
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