Publications: Dr Fabian Flores-Borja
Graham R, Gazinska P, Zhang B, Khiabany A, Sinha S, Alaguthurai T, Flores-Borja F, Vicencio J et al.
(
2023
)
.
Serum-derived extracellular vesicles from breast cancer patients contribute to differential regulation of T-cell-mediated immune-escape mechanisms in breast cancer subtypes
.
Frontiers in Immunology
vol.
14
,
Barber PR, Mustapha R, Flores-Borja F, Alfano G, Ng K, Weitsman G, Dolcetti L, Mohamed AA et al.
(
2022
)
.
Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development
.
eLife
vol.
11
,
Soria-Castro R, Meneses-Preza YG, Rodríguez-López GM, Ibarra-Sánchez A, González-Espinosa C, Pérez-Tapia SM, Flores-Borja F, Estrada-Parra S et al.
(
2022
)
.
Valproic acid restricts mast cell activation by Listeria monocytogenes
.
Scientific Reports
vol.
12
,
(
1
)
Flores-Borja F, Blair P
(
2022
)
.
Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses
.
Clinical & Experimental Immunology
vol.
209
,
(
1
)
33
-
45
.
Vicencio JM, Evans R, Green R, An Z, Deng J, Treacy C, Mustapha R, Monypenny J et al.
(
2022
)
.
Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans
.
Cell Death & Disease
vol.
13
,
(
3
)
Parkinson EK, Adamski J, Zahn G, Gaumann A, Flores-Borja F, Ziegler C, Mycielska ME
(
2021
)
.
Extracellular citrate and metabolic adaptations of cancer cells
.
Cancer and Metastasis Reviews
vol.
40
,
(
4
)
1073
-
1091
.
Soria-Castro R, Chávez-Blanco AD, García-Pérez BE, Wong-Baeza I, Flores-Mejía R, Flores-Borja F, Estrada-Parra S, Estrada-García I et al.
(
2020
)
.
Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection
.
Scientific Reports
vol.
10
,
(
1
)
Gómez V, Eykyn TR, Mustapha R, Flores-Borja F, Male V, Barber PR, Patsialou A, Green R et al.
(
2020
)
.
Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
.
Science Signaling
vol.
13
,
(
652
)
Rodríguez-López GM, Soria-Castro R, Campillo-Navarro M, Pérez-Tapia SM, Flores-Borja F, Wong-Baeza I, Muñoz-Cruz S, López-Santiago R et al.
(
2020
)
.
The histone deacetylase inhibitor valproic acid attenuates phospholipase Cγ2 and IgE-mediated mast cell activation
.
Journal of Leukocyte Biology
An Z, Flores-Borja F, Irshad S, Deng J, Ng T
(
2020
)
.
Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer
.
Frontiers in Immunology
vol.
10
,
Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C et al.
(
2019
)
.
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer
.
Cell Reports
vol.
27
,
(
7
)
1967
-
1978.e4
.
Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A et al.
(
2018
)
.
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
.
Cell Reports
vol.
24
,
(
3
)
630
-
641
.
Ng T, Flores-Borja F, Alfano G, Barber P, Weitsman G, Wong F
(
2018
)
.
The use of exosome and immune profiling to analyze a phase 2 study on the addition of patritumab or placebo to cetuximab and a platinum agent for recurrent / metastatic head and neck cancer (R/M HNSCC) patients
.
JOURNAL OF CLINICAL ONCOLOGY
.
Conference:
2018 American Society of Clinical Oncology
vol.
36
,
Eisenblaetter M, Flores-Borja F, Lee JJ, Wefers C, Smith H, Hueting R, Cooper MS, Blower PJ et al.
(
2017
)
.
Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment
.
Theranostics
vol.
7
,
(
9
)
2392
-
2401
.
Irshad S, Flores-Borja F, Lawler K, Monypenny J, Evans R, Male V, Gordon P, Cheung A et al.
(
2017
)
.
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers
.
Cancer Res
vol.
77
,
(
5
)
1083
-
1096
.
Flores-Borja F, Irshad S, Gordon P, Wong F, Sheriff I, Tutt A, Ng T
(
2016
)
.
Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment
.
Journal of Immunology Research
vol.
2016
,
Becker A, Hokamp NG, Zenker S, Flores-Borja F, Barzcyk K, Varga G, Roth J, Geyer C et al.
(
2015
)
.
Optical In Vivo Imaging of the Alarmin S100A9 in Tumor Lesions Allows for Estimation of the Individual Malignant Potential by Evaluation of Tumor–Host Cell Interaction
.
Journal of Nuclear Medicine
vol.
56
,
(
3
)
450
-
456
.
Irshad S, Lawler K, Flores-Borja F, Monypenny J, Evans R, Grigoriadis A, Fruhwirth G, Cheung A et al.
(
2014
)
.
Effect of lymphoid tissue inducer cells on lymphatic tumor cell invasion via activation of the RANKL/RANK axis within triple-negative breast cancers
.
Journal of Clinical Oncology
.
vol.
32
,
11082
-
11082
.
Irshad S, Lawler K, Evans R, Flores-Borja F, Monypenny J, Grigoriadis A, Fruhwith G, Poland S et al.
(
2013
)
.
Abstract P5-01-01: Lymphoid tissue inducer cells: Identification of a novel immune cell within the breast tumour microenvironment and its role in promoting tumour cell invasion
.
Cancer Research
.
vol.
73
,
Taher TE, Muhammad HA, Bariller E, Flores-Borja F, Renaudineau Y, Isenberg DA, Mageed RA
(
2013
)
.
B-Lymphocyte Signalling Abnormalities and Lupus Immunopathology
.
International Reviews of Immunology
vol.
32
,
(
4
)
428
-
444
.
Taher TE, Muhammad HA, Rahim A, Flores‐Borja F, Renaudineau Y, Isenberg DA, Mageed RA
(
2013
)
.
Aberrant B‐lymphocyte responses in lupus: inherent or induced and potential therapeutic targets
.
European Journal of Clinical Investigation
vol.
43
,
(
8
)
866
-
880
.
Irshad S, Flores-Borja FF, Evans R, Fruhwirth G, Pitmilly JM, Poland S, Ameer-Beg S, Tutt A et al.
(
2013
)
.
89O Use of Live In-Vivo Lymphatic Imaging Techniques to Study the Effects of Immune Cell Interactions in a Syngeneic Mouse Model of Breast Cancer
.
Annals of Oncology
vol.
24
,
Flores-Borja F, Bosma A, Ng D, Reddy V, Ehrenstein MR, Isenberg DA, Mauri C
(
2013
)
.
CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation
.
Science Translational Medicine
vol.
5
,
(
173
)
Taher TE, Parikh K, Flores‐Borja F, Mletzko S, Isenberg DA, Peppelenbosch MP, Mageed RA
(
2010
)
.
Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus
.
Arthritis & Rheumatism
vol.
62
,
(
8
)
2412
-
2423
.
Jury EC, Flores‐Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR
(
2010
)
.
Abnormal CTLA‐4 function in T cells from patients with systemic lupus erythematosus
.
European Journal of Immunology
vol.
40
,
(
2
)
569
-
578
.
Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
(
2010
)
.
CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
.
Immunity
vol.
32
,
(
1
)
129
-
140
.
Mauri C, Carter NA, Flores-Borja F, Blair PA
(
2010
)
.
More than T regs, the relevance of other lymphocytes
.
IMMUNOLOGY
.
vol.
131
,
18
-
18
.
Flores-Borja F, Cambridge G, Ng D, Turi M, Ehrenstein MR, Isenberg D, Mauri C
(
2010
)
.
Regulatory B cells prevent the differentiation of naive CD4<SUP>+</SUP>T-cells into TH1 and TH17 but favour FOXP3+Tregs development
.
IMMUNOLOGY
.
vol.
131
,
62
-
63
.
Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR
(
2008
)
.
Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
.
Proceedings of the National Academy of Sciences of the United States of America
vol.
105
,
(
49
)
19396
-
19401
.
Flores‐Borja F, Mauri C, Ehrenstein MR
(
2008
)
.
Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis
.
European Journal of Immunology
vol.
38
,
(
4
)
934
-
937
.
Jury EC, Flores-Borja F, Isenberg DA, Mauri C, Ehrenstein MR
(
2008
)
.
Abnormal CTLA-4 function in lupus patients is associated with induction of a defective population of FOXP3+regulatory T cells via TGF
.
RHEUMATOLOGY
.
vol.
47
,
II64
-
II64
.
Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR
(
2008
)
.
Abnormal cytotoxic T lymphocyte antigen-4 function in lupus patients is associated with induction of defective Foxp3+Treg
.
IMMUNOLOGY
.
vol.
125
,
38
-
38
.
Flores-Borja F, Jury EC, Ehrenstein MR
(
2008
)
.
Defective CTLA-4 function in regulatory T cells from patients with rheumatoid arthritis: A potential target for therapy
.
RHEUMATOLOGY
.
vol.
47
,
II55
-
II55
.
Jury EC, Flores-Borja F, Kabouridis PS
(
2007
)
.
Lipid rafts in T cell signalling and disease
.
SEMIN CELL DEV BIOL
vol.
18
,
(
5
)
608
-
615
.
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA
(
2007
)
.
Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus
.
Arthritis Rheum
vol.
56
,
(
1
)
291
-
302
.
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA
(
2006
)
.
Lyn deficiency in B cells from patients with systemic lupus erythematosus: comment on the article by Flores-Borja et al - Reply
.
ARTHRITIS RHEUM
vol.
54
,
(
6
)
2037
-
2038
.
Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA
(
2005
)
.
Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus
.
Arthritis Rheum
vol.
52
,
(
12
)
3955
-
3965
.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA
(
2005
)
.
Translocation of CD45 to lipid raft signalling domains and abnormal relocation during B-lymphocyte activation in SLE
.
RHEUMATOLOGY
.
vol.
44
,
I17
-
I17
.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA
(
2004
)
.
Altered lipid raft–associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
.
Journal of Clinical Investigation
vol.
113
,
(
8
)
1176
-
1187
.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA
(
2004
)
.
Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
.
J CLIN INVEST
vol.
113
,
(
8
)
1176
-
1187
.
Flores-Borja F, Kieszkievicz J, Church V, Francis-West PH, Schofield J, Rademacher TW, Lund T
(
2004
)
.
Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D
.
Biochimie
vol.
86
,
(
4-5
)
275
-
282
.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA
(
2004
)
.
ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
.
RHEUMATOLOGY
.
vol.
43
,
24
-
24
.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA
(
2004
)
.
ATYPICAL CO-LOCALISATION OF CD45 AND LYN TO LIPID RAFT SIGNALLING DOMAINS CORRELATES WITH B-LYMPHOCYTE HYPER RESPONSIVENESS IN PATIENTS WITH LUPUS
.
RHEUMATOLOGY
.
vol.
43
,
108
-
108
.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA
(
2003
)
.
Abnormal co-localisation of CD45 and lipid rafts is associated with reduced LCK expression in T cells from patients with SLE
.
ARTHRITIS AND RHEUMATISM
.
vol.
48
,
S193
-
S193
.
Flores-Borja F, Kabouridis PS, Jury E, Isenberg D, Mageed RA
(
2003
)
.
ANALYSIS OF LIPID RAFT-ASSOCIATED SIGNALLING MOLECULES IN B CELLS FROM NORMAL AND PATIENTS WITH SLE
.
RHEUMATOLOGY
.
vol.
42
,
72
-
73
.
Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA
(
2003
)
.
CD45 IS ABNORMALLY ASSOCIATED WITH LIPID RAFTS IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
.
RHEUMATOLOGY
.
vol.
42
,
5
-
5
.
Monroy-Garcı́a A, Ortı́z-Navarrete VF, de Lourdes Mora-Garcı́a M, Flores-Borja F, Diaz-Quiñonez A, Isibasi-Araujo A, Trejo-Becerril C, Chacón-Salinas R et al.
(
1999
)
.
Identification of peptides presented by HLA class I molecules on cervical cancer cells with HPV-18 infection
.
Immunology Letters
vol.
67
,
(
3
)
167
-
177
.
Flores-Borja F, Santiago E, Weiss-Steider B
(
1998
)
.
Fc gamma receptors in health and disease
.
Revista de Investigación Clínica
vol.
50
,
(
6
)
529
-
540
.