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Research

Publications: Dr Sadani Cooray

Gobbetti T, Cooray SN ( 2016 ) . Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature . Biological Chemistry vol. 397 , ( 10 ) 981 - 993 .
Gobbetti T, Toller-Kawahisa JE, Cooray SN, Flower RJ, Perretti M ( 2016 ) . New link between the AnxA1/FPR2 system and activation of AMP-activated protein kinase . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION . vol. 46 , 93 - 93 .
Montero-Melendez T, Gobbetti T, Cooray SN, Jonassen TE, Perretti M ( 2015 ) . Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects . J Immunol vol. 194 , ( 7 ) 3381 - 3388 .
Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJL, Flower RJ, Perretti M ( 2013 ) . Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses . Proc Natl Acad Sci U S A vol. 110 , ( 45 ) 18232 - 18237 .
Cooray SN, Clark A, Flower R, Perretti M ( 2013 ) . Agonist-induced conformational change of the Formyl Peptide Receptors . FASEB JOURNAL . vol. 27 ,
Cooray SN, Guasti L, Clark AJL ( 2011 ) . The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor . Endocrinology vol. 152 , ( 11 ) 4224 - 4231 .
Cooray SN, Chung T-T, Mazhar K, Szidonya L, Clark AJL ( 2011 ) . Bioluminescence resonance energy transfer reveals the adrenocorticotropin (ACTH)-induced conformational change of the activated ACTH receptor complex in living cells . Endocrinology vol. 152 , ( 2 ) 495 - 502 .
Cooray SN, Clark AJL ( 2011 ) . Melanocortin receptors and their accessory proteins . Mol Cell Endocrinol vol. 331 , ( 2 ) 215 - 221 .
Metherell LA, Cooray S, Huebner A, Ruschendorf F, Naville D, Begeot M, Clark AJL ( 2004 ) . Mutations in a Novel Gene, Encoding a Single Transmembrane Domain Protein Are Associated with Familial Glucocorticoid Deficiency Type 2 . Endocrine Research . vol. 30 , 889 - 890 .
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M et al. ( 2009 ) . MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family . Proc Natl Acad Sci U S A vol. 106 , ( 15 ) 6146 - 6151 .
Cooray SN, Chan L, Webb TR, Metherell L, Clark AJL ( 2009 ) . Accessory proteins are vital for the functional expression of certain G protein-coupled receptors . Mol Cell Endocrinol vol. 300 , ( 1-2 ) 17 - 24 .
Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP, Clark AJL ( 2009 ) . Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking . Endocrinology vol. 150 , ( 2 ) 720 - 726 .
Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP, Clark AJL ( 2008 ) . The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface . J Clin Endocrinol Metab vol. 93 , ( 12 ) 4948 - 4954 .
Cooray SN, Almiro Do Vale I, Leung K-Y, Webb TR, Chapple JP, Egertová M, Cheetham ME, Elphick MR et al. ( 2008 ) . The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line . Endocrinology vol. 149 , ( 4 ) 1935 - 1941 .
Cooray SN, Chan L, Metherell L, Storr H, Clark AJL ( 2008 ) . Adrenocorticotropin resistance syndromes . Endocr Dev vol. 13 , 99 - 116 .
Khoo B, CLARK AJL, David A, Cooray S, Metherell LA, Becker C, Huebner A, Nurnberg P et al. ( 2005 ) . Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2 . Nature Genetics vol. 37 , ( 2 ) 166 - 170 .