Publications: Dr Pedro Rodriguez Cutillas
Martín Guerrero SM, Casado P, Hijazi M, Rajeeve V, Plaza J, Abadía-Molina F, Navascués J, Cuadros MA et al.
(
2020
)
.
PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability
.
Biochem J
Akhtar N, Baig MW, Haq I-U, Rajeeve V, Cutillas PR
(
2020
)
.
Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells
.
Biomedicines
vol.
8
,
(
9
)
Xu R, Jones W, Wilcz-Villega E, Costa ASH, Rajeeve V, Bentham RB, Bryson K, Nagano A et al.
(
2020
)
.
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism
.
EMBO Reports
vol.
21
,
(
9
)
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al.
(
2020
)
.
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer
.
npj Breast Cancer
vol.
6
,
(
1
)
Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C et al.
(
2020
)
.
A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity
.
British Journal of Cancer
vol.
123
,
(
4
)
542
-
555
.
Patani H, Rushton MD, Higham J, Teijeiro SA, Oxley D, Cutillas P, Sproul D, Ficz G
(
2020
)
.
Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
.
Nat Commun
vol.
11
,
(
1
)
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O et al.
(
2020
)
.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
.
Cell
vol.
181
,
(
6
)
1346
-
1363.e21
.
Invergo BM, Petursson B, Akhtar N, Bradley D, Giudice G, Hijazi M, Cutillas P, Petsalaki E et al.
(
2020
)
.
Prediction of Signed Protein Kinase Regulatory Circuits
.
Cell Syst
vol.
10
,
(
5
)
384
-
396.e9
.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.
(
2020
)
.
Cancer associated fibroblast FAK regulates malignant cell metabolism
.
Nature Communications
vol.
11
,
(
1
)
1290
-
1290
.
Huang KW, Reebye V, Czysz K, Ciriello S, Dorman S, Reccia I, Lai HS, Peng L et al.
(
2020
)
.
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
.
Molecular Therapy - Nucleic Acids
vol.
19
,
361
-
370
.
Fernández-Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías-Muñoz L et al.
(
2020
)
.
Bespoken nanoceria: A new effective treatment in experimental hepatocellular carcinoma
.
Hepatology
Hijazi M, Smith R, Rajeeve V, Bessant C, Cutillas PR
(
2020
)
.
Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
.
Nature Biotechnology
Cutillas PR, Hijazi M, Smith R, Bessant C, Britton D
(
2019
)
.
Abstract C088: Chemical phosphoproteomics systematically identifies circuitries of kinase networks in cancer cells and predicts their response to kinase inhibitors
.
c088
-
c088
.
Grey W, Casado-Izquierdo P, Cutillas P, Bonnet D
(
2019
)
.
Combination Therapy Targeting CKS1-Dependent Protein Degradation Reduces AML Burden Whilst Protecting Normal Haematopoietic Stem Cellsfrom Cytarabine Toxicity
.
Blood
vol.
134
,
(
Supplement_1
)
2535
-
2535
.
Edelmann J, Dokal A, Holzmann K, Britton DJ, Vilventhraraja E, Smith RJ, Cragg MS, Braun A et al.
(
2019
)
.
Rituximab and Obinutuzumab Induce Direct B-Cell Death Via B-Cell Receptor (BCR) Signaling, but Rituximab Elicits Stronger BCR-Derived Pro-Survival Signals Diminishing Apoptosis
.
Blood
vol.
134
,
(
Supplement_1
)
1579
-
1579
.
Martín-Guerrero SM, Casado P, Muñoz-Gámez JA, Carrasco M-C, Navascués J, Cuadros MA, López-Giménez JF, Cutillas PR et al.
(
2019
)
.
Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells
.
Exp Eye Res
vol.
188
,
Thomas JR, Moore KM, Sproat C, Mo S, Wolanska KI, Maldonado H, Haider S, Newman D et al.
(
2019
)
.
Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
.
vol.
100
,
A39
-
A39
.
Alrawashdeh W, Jones R, Dumartin L, Radon TP, Cutillas PR, Feakins RM, Dmitrovic B, Demir IE et al.
(
2019
)
.
Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling
.
Mol Oncol
vol.
13
,
(
5
)
1075
-
1091
.
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al.
(
2019
)
.
Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
.
PLoS Biology
vol.
17
,
(
12
)
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR et al.
(
2018
)
.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics
.
Journal of Proteome Research
vol.
16
,
(
8
)
3083
-
3091
.
Ferrandiz N, Barroso C, Telecan O, Shao N, Kim HM, Testori S, Faull P, Cutillas P et al.
(
2018
)
.
Erratum to: Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis (Nature Communications, (2018), 9, 1, (834), 10.1038/s41467-018-03229-5)
.
Nature Communications
vol.
9
,
(
1
)
Ferrandiz N, Barroso C, Telecan O, Shao N, Kim HM, Testori S, Faull P, Cutillas P et al.
(
2018
)
.
Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. Elegans oocyte meiosis
.
Nature Communications
vol.
9
,
(
1
)
Edelmann J, Britton DJ, Vilventhraraja E, Dokal A, Holzmann K, Cragg MC, Braun A, Cutillas P et al.
(
2018
)
.
Anti-CD20 Monoclonal Antibodies Hijack the B-Cell Receptor Signaling Cascade Thereby Activating the NOTCH1 Signaling Pathway
.
Blood
.
vol.
132
,
588
-
588
.
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C et al.
(
2018
)
.
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
.
Developmental Cell
vol.
47
,
(
4
)
409
-
424.e9
.
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V et al.
(
2018
)
.
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
.
Nat Commun
vol.
9
,
(
1
)
Simon T, Pinioti S, Schellenberger P, Rajeeve V, Wendler F, Cutillas PR, King A, Stebbing J et al.
(
2018
)
.
Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma
.
Mol Cancer
vol.
17
,
(
1
)
Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al.
(
2018
)
.
Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells
.
Leukemia
vol.
32
,
(
8
)
1818
-
1822
.
Tummala H, Dokal AD, Walne A, Ellison A, Cardoso S, Amirthasigamanipillai S, Kirwan M, Browne I et al.
(
2018
)
.
Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants
.
Proc Natl Acad Sci U S A
vol.
115
,
(
30
)
7777
-
7782
.
Corominas MP, Restoy SC, Casals G, Oró D, Ribera J, Casals E, Casado-Izquierdo P, Varo GF et al.
(
2018
)
.
THU-028 Cerium oxide nanoparticles protect against oxidant mediated injury and recover kinase activity of multiple pathways in human-derived hepatocellular carcinoma cells
.
Journal of Hepatology
.
vol.
68
,
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al.
(
2018
)
.
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
.
Cell Reports
vol.
22
,
(
9
)
2469
-
2481
.
Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al.
(
2017
)
.
Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells
.
Leukemia
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.
(
2017
)
.
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
.
Cancer Discov
Kyprianou N, Gregory L, Vignola ML, Marinelli E, Gualtieri A, Scagliotti V, Davis S, Casado P et al.
(
2017
)
.
The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF Cause Congenital hypopituitarism
.
Endocrine Abstracts
Dermit M, Dokal A, Cutillas PR
(
2017
)
.
Approaches to identify kinase dependencies in cancer signalling networks
.
FEBS Lett
vol.
591
,
(
17
)
2577
-
2592
.
Wilkes EH, Casado P, Rajeeve V, Cutillas PR
(
2017
)
.
Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability
.
Mol Cell Proteomics
vol.
16
,
(
9
)
1694
-
1704
.
Cutillas PR
(
2017
)
.
Systems Biology of Oncogenic Signaling
.
MOLECULAR & CELLULAR PROTEOMICS
.
vol.
16
,
S15
-
S15
.
Wilkes E, Cutillas PR
(
2017
)
.
Label-Free Phosphoproteomic Approach for Kinase Signaling Analysis
.
Methods Mol Biol
vol.
1636
,
199
-
217
.
Yuzugulen J, Douthwaite JA, Wood EG, Villar IC, Patel NSA, Jegard J, Gaertner H, Rossitto-Borlat I et al.
(
2017
)
.
Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1
.
Sci Rep
vol.
7
,
(
1
)
4956
-
4956
.
Casado-Izquierdo P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Sameena I et al.
(
2017
)
.
PHOSPHOPROTEOMICS AND MASS CYTOMETRY SIGNATURES OF PRIMARY AML CELL DIFFERENTIATION ARE ASSOCIATED WITH SENSITIVITY TO KINASE INHIBITORS
.
HAEMATOLOGICA
.
vol.
102
,
203
-
203
.
Fernandez-Varo G, Oro D, Yudina T, Carvajal S, Marfa S, Boix L, Perramon M, Oller L et al.
(
2017
)
.
Cerium oxide nanoparticles display anti-tumoral activity and improve survival in experimental hepatocellular carcinoma
.
JOURNAL OF HEPATOLOGY
.
Conference:
The International Liver Congress™ EASL 2017 - European Association for the Study of the Live
(
Amsterdam, Holland
)
from:
19/04/2017
to:
23/04/2017
,
vol.
66
,
S229
-
S230
.
Cutillas PR
(
2017
)
.
Targeted In-Depth Quantification of Signaling Using Label-Free Mass Spectrometry
.
Methods Enzymol
vol.
585
,
245
-
268
.
Graupera M, Angulo-Urarte A, Kobialka P, Castel P, Casado PM, Affolter M, Gerhardt H, Belting H-G et al.
(
2017
)
.
The p110alpha/PI3K controls endothelial cell rearrangements during angiogenesis by stimulating MLC2 dephosphorylation
.
JOURNAL OF VASCULAR RESEARCH
.
vol.
54
,
73
-
73
.
Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al.
(
2016
)
.
Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
.
Oncogene
Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E et al.
(
2016
)
.
NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia
.
Journal of the American Heart Association
vol.
5
,
(
12
)
e004629
-
e004629
.
Casado P, Wilkes E, Hadi MM, Rajeeve V, Miraki-Moud F, Pike R, Del Rio-Machin A, Iqbal S et al.
(
2016
)
.
Differentiation Status Revealed By Shotgun Phosphoproteomics Determines Sensitivity of Primary AML Cells to Kinase Inhibitors
.
Blood
.
vol.
128
,
840
-
840
.
Britton DJ, Wilkes E, Casado P, Rajeeve V, Fitzgibbon J, Gribben J, Cutillas PR
(
2016
)
.
Proteomic Analysis Directs Effective Drug Selection in Relapsed AML By Quantifying Drug Targets
.
Blood
.
vol.
128
,
5265
-
5265
.
Villoria MT, Ramos F, Dueñas E, Faull P, Cutillas PR, Clemente-Blanco A
(
2016
)
.
Stabilization of the metaphase spindle by Cdc14 is required for recombinational DNA repair
.
EMBO J
vol.
36
,
(
1
)
79
-
101
.
Prysyazhna O, Scotcher J, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.
(
2016
)
.
348 Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation
.
Free Radical Biology and Medicine
.
vol.
100
,
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O et al.
(
2016
)
.
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response
.
Nature Communications
vol.
7
,
13187
-
13187
.
Casado P, Hijazi M, Britton D, Cutillas PR
(
2016
)
.
Impact of phosphoproteomics in the translation of kinase targeted therapies
.
Proteomics
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa ASH, Gaude E, Drubbel AV, Theobald SJ et al.
(
2016
)
.
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
.
Nature
vol.
537
,
(
7621
)
544
-
547
.
Bouchekioua-Bouzaghou K, Lenihan C, Shia A, Wilkes E, Casado-Izquierdo P, Cutillas P, Schmid P
(
2016
)
.
Abstract 2819: Characterization of the mechanisms of early and later stages of resistance to the selective CDK4/6 inhibitor palbociclib
.
2819
-
2819
.
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH et al.
(
2016
)
.
A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases
.
Clinical Cancer Research
Kulbe H, Iorio F, Chakravarty P, Milagre CS, Moore R, Thompson RG, Everitt G, Canosa M et al.
(
2016
)
.
Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells
.
Oncotarget
vol.
7
,
(
13
)
15648
-
15661
.
Lenihan C, Bouchekioua-Bouzaghou K, Shia A, Wilkes E, Casado-Izquierdo P, Cutillas P, Schmid P
(
2016
)
.
Abstract P3-06-02: Characterization of resistance to the selective CDK4/6 inhibitor palbociclib in ER positive breast cancer
.
Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT et al.
(
2016
)
.
Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion
.
Cell Reports
vol.
14
,
(
3
)
440
-
448
.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, Adachi H, Adams CM et al.
(
2016
)
.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
.
Autophagy
vol.
12
,
(
1
)
1
-
222
.
Cutillas PR, Crnogorac-Jurcevic T
(
2016
)
.
Application of Proteomics in Cancer Biomarker Discovery: GeLC-MS/MS
.
Methods Mol Biol
vol.
1381
,
201
-
209
.
Arnandis T, Rajeeve V, Brennan CH, Cutillas PR, Godinho SA
(
2016
)
.
Paracrine-mediated invasion induced by centrosome amplification
.
MOLECULAR BIOLOGY OF THE CELL
.
vol.
27
,
Terfve CDA, Wilkes EH, Casado P, Cutillas PR, Saez-Rodriguez J
(
2015
)
.
Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data
.
Nat Commun
vol.
6
,
Carretero L, Llavona P, López-Hernández A, Casado P, Cutillas PR, de la Peña P, Barros F, Domínguez P
(
2015
)
.
ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells
.
Cell Signal
vol.
27
,
(
9
)
1720
-
1730
.
Wilkes EH, Terfve C, Gribben JG, Saez-Rodriguez J, Cutillas PR
(
2015
)
.
Empirical inference of circuitry and plasticity in a kinase signaling network
.
Proc Natl Acad Sci U S A
vol.
112
,
(
25
)
7719
-
7724
.
Cutillas PR
(
2015
)
.
Role of phosphoproteomics in the development of personalized cancer therapies
.
Proteomics Clin Appl
vol.
9
,
(
3-4
)
383
-
395
.
Rotival M, Ko J-H, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR et al.
(
2015
)
.
Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation
.
Mol Cell Proteomics
vol.
14
,
(
3
)
484
-
498
.
Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RDS, McFarland R, Schaefer AM et al.
(
2015
)
.
The urinary proteome and metabonome differ from normal in adults with mitochondrial disease
.
Kidney Int
vol.
87
,
(
3
)
610
-
622
.
Wilkes EH, Casado P, Cutillas PR
(
2014
)
.
Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies
.
Biochem Soc Trans
vol.
42
,
(
4
)
791
-
797
.
Rajeeve V, Vendrell I, Wilkes E, Torbett N, Cutillas PR
(
2014
)
.
Cross-species proteomics reveals specific modulation of signaling in cancer and stromal cells by phosphoinositide 3-kinase (PI3K) inhibitors
.
Mol Cell Proteomics
vol.
13
,
(
6
)
1457
-
1470
.
Casado P, Bilanges B, Rajeeve V, Vanhaesebroeck B, Cutillas PR
(
2014
)
.
Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells
.
MOLECULAR & CELLULAR PROTEOMICS
vol.
13
,
(
3
)
836
-
848
.
Yuzugulen J, Wood EG, Villar IC, Douthwaite JA, Patel NSAI, Jegard J, Montoya A, Cutillas P et al.
(
2013
)
.
Characterisation of the “Endothelin-Like Domain Peptide” (ELDP) co-synthesised with Endothelin-1 from the EDN1 gene
.
Life Sciences
vol.
93
,
(
25-26
)
Lumb S, Torbett N, Vendrell I, Turner H, Page M, Hales P, Maloney A, Vanhaesebroeck B et al.
(
2013
)
.
THU0045 Epratuzumab, an Antibody Targeting CD22 on B Cells, Induces Phosphoprotein Changes Following B-Cell Receptor Activation in Vitro
.
Annals of the Rheumatic Diseases
vol.
72
,
(
Suppl 3
)
Casado P, Alcolea MP, Iorio F, Rodríguez-Prados J-C, Vanhaesebroeck B, Saez-Rodriguez J, Joel S, Cutillas PR
(
2013
)
.
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
.
Genome Biol
vol.
14
,
(
4
)
Casado P, Rodriguez-Prados J-C, Cosulich SC, Guichard S, Vanhaesebroeck B, Joel S, Cutillas PR
(
2013
)
.
Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells
.
Sci Signal
vol.
6
,
(
268
)
Rajeeve V, Pearce W, Cascante M, Vanhaesebroeck B, Cutillas PR
(
2013
)
.
Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth
.
Biochem J
vol.
450
,
(
3
)
619
-
628
.
Alrawashdeh W, Jones R, Cutillas P, Wijesuriya N, Crnogorac-Jurcevic T
(
2013
)
.
Proteomic analysis of perineural invasion in pancreatic adenocarcinoma reveals up-regulation of neurosecretory protein VGF in invaded nerves
.
Pancreatology
vol.
13
,
(
2
)
Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR
(
2012
)
.
Global profiling of protein kinase activities in cancer cells by mass spectrometry
.
J Proteomics
vol.
77
,
492
-
503
.
Butler T, Montoya A, Clear AJ, Coutinho R, Taussig DC, Cutillas P, Gribben JG
(
2012
)
.
Anergic Response to B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia: The Differing Roles of IgD and IgM in the Microenvironment and Peripheral Blood
.
Blood
.
vol.
120
,
2889
-
2889
.
Beltran L, Cutillas PR
(
2012
)
.
Advances in phosphopeptide enrichment techniques for phosphoproteomics
.
Amino Acids
vol.
43
,
(
3
)
1009
-
1024
.
Cappadona S, Baker PR, Cutillas PR, Heck AJR, van Breukelen B
(
2012
)
.
Current challenges in software solutions for mass spectrometry-based quantitative proteomics
.
AMINO ACIDS
vol.
43
,
(
3
)
1087
-
1108
.
Alcolea MP, Casado P, Rodríguez-Prados J-C, Vanhaesebroeck B, Cutillas PR
(
2012
)
.
Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance
.
Mol Cell Proteomics
vol.
11
,
(
8
)
453
-
466
.
Kitromilidou C, McDonald D, Cutillas P, Ghazaly E, Perry J, Csaba B, Joel S, Powles T
(
2012
)
.
Abstract 1792: The potential role of targeting HER1-4 in bladder cancer
.
1792
-
1792
.
Kulbe H, Chakravarty P, Moore R, Iorio F, Montoya A, Saez-Rodriguez J, Cutillas P, Balkwill F
(
2012
)
.
Abstract 49: Targeting the TNF network in human ovarian cancer - A systems biology approach
.
49
-
49
.
Burling KA, Cutillas PR, Church D, Lapsley M, Norden AGW
(
2012
)
.
Analysis of molecular forms of urine Retinol-Binding Protein in Fanconi Syndrome and design of an accurate immunoassay
.
CLINICA CHIMICA ACTA
vol.
413
,
(
3-4
)
483
-
489
.
Worthington J, Cutillas PR, Timms JF
(
2011
)
.
IMAC/TiO2 enrich for peptide modifications other than phosphorylation: Implications for chromatographic choice and database searching in phosphoproteomics
.
PROTEOMICS
vol.
11
,
(
23
)
4583
-
4587
.
Beltran L, Chaussade C, Vanhaesebroeck B, Cutillas PR
(
2011
)
.
Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity
.
Proc Natl Acad Sci U S A
vol.
108
,
(
39
)
16217
-
16222
.
Montoya A, Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR
(
2011
)
.
Characterization of a TiO₂ enrichment method for label-free quantitative phosphoproteomics
.
Methods
vol.
54
,
(
4
)
370
-
378
.
Cutillas PR, Jørgensen C
(
2011
)
.
Biological signalling activity measurements using mass spectrometry
.
Biochem J
vol.
434
,
(
2
)
189
-
199
.
Casado P, Cutillas PR
(
2011
)
.
A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments
.
Mol Cell Proteomics
vol.
10
,
(
1
)
Jueliger S, Maharaj L, Iyengar S, Ghazaly E, Cutillas P, Auer R, Rommel C, Li L et al.
(
2010
)
.
Abstract 4489: The activity of novel, potent, selective PI3K/mTOR pathway inhibitors in B-cell malignancies
.
4489
-
4489
.
Cutillas PR
(
2010
)
.
Analysis of peptides in biological fluids by LC-MS/MS
.
Methods Mol Biol
vol.
658
,
311
-
321
.
Cutillas PR, Timms JF
(
2010
)
.
Approaches and applications of quantitative LC-MS for proteomics and activitomics
.
Methods Mol Biol
vol.
658
,
3
-
17
.
Alcolea MP, Cutillas PR
(
2010
)
.
In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry
.
Methods Mol Biol
vol.
658
,
111
-
126
.
Alcolea MP, Cutillas PR
(
2010
)
.
Quantification of protein kinase activities by LC-MS
.
Methods Mol Biol
vol.
658
,
325
-
337
.
Cutillas PR
(
2009
)
.
Quantifying oncogenic signalling by mass spectrometry
.
AMINO ACIDS
vol.
37
,
(
4
)
762
-
762
.
Alcolea MP, Kleiner O, Cutillas PR
(
2009
)
.
Increased confidence in large-scale phosphoproteomics data by complementary mass spectrometric techniques and matching of phosphopeptide data sets
.
J Proteome Res
vol.
8
,
(
8
)
3808
-
3815
.
Quintana LF, Campistol JM, Alcolea MP, Banon-Maneus E, Sole-Gonzalez A, Cutillas PR
(
2009
)
.
Application of Label-free Quantitative Peptidomics for the Identification of Urinary Biomarkers of Kidney Chronic Allograft Dysfunction
.
MOL CELL PROTEOMICS
vol.
8
,
(
7
)
1658
-
1673
.
Vilasi A, Cutillas PR, Unwin RJ
(
2008
)
.
Application of proteomic techniques to the study of urine and renal tissue
.
PROTEOM CLIN APPL
vol.
2
,
(
12
)
1564
-
1574
.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S et al.
(
2008
)
.
Angiogenesis selectively requires the p110 alpha isoform of PI3K to control endothelial cell migration
.
NATURE
vol.
453
,
(
7195
)
662
-
U9
.
Cutillas PR, Vanhaesebroeck B
(
2007
)
.
Quantitative profile of five murine core proteomes using label-free functional proteomics
.
Mol Cell Proteomics
vol.
6
,
(
9
)
1560
-
1573
.
Vilasi A, Cutillas PR, Maher AD, Zirah SFM, Capasso G, Norden AWG, Holmes E, Nicholson JK et al.
(
2007
)
.
Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome
.
Am J Physiol Renal Physiol
vol.
293
,
(
2
)
F456
-
F467
.
Cutillas PR, Vanhaesebroeck B
(
2007
)
.
Profiling protein expression by label-free quantitative mass Spectrometry
.
MOL CELL PROTEOMICS
vol.
6
,
(
8
)
14
-
14
.
Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B
(
2007
)
.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
.
Proc Natl Acad Sci U S A
vol.
104
,
(
19
)
7809
-
7814
.
VANHAESEBROECK BAM, Gharbi SL, Nock G, Geering B, Cutillas PR
(
2007
)
.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
.
Proc Natl Acad Sci U S A
vol.
104
,
7809
-
7814
.
CUTILLAS PR, Vanhaesebroeck BAM, Khwaja A, Waterfield M, Gharbi S, Pearce W, Graupera M
(
2006
)
.
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
.
Proc Natl Acad Sci USA
vol.
103
,
(
24
)
8959
-
8964
.
Cutillas PR, Geering B, Waterfield MD, Vanhaesebroeck B
(
2005
)
.
Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line
.
Mol Cell Proteomics
vol.
4
,
(
8
)
1038
-
1051
.
CUTILLAS PR, Biber J, Marks J, Waterfield M, Cramer R, Stieger B, Jacob R, Burlingame AL et al.
(
2005
)
.
Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex
.
Proteomics
vol.
5
,
(
1
)
101
-
112
.
CUTILLAS PR, Burlingame AL, Waterfield MD, Norden AG, Cramer R, Hansen KC, Chalkley RJ, Unwin RJ
(
2004
)
.
The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells
.
Am J Physiol Renal Physiol
vol.
287
,
(
3
)
F353
-
F364
.