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Research

Publications: Dr Emanuela Carlotti

Michaeli M, Carlotti E, Hazanov H, Gribben JG, Mehr R ( 2022 ) . Mutational patterns along different evolution paths of follicular lymphoma . Frontiers in Oncology vol. 12 ,
Lin M-L, Hickey JW, Schurch CM, Carlotti E, Passman AM, Hackett RJ, Devkumar S, Evans JA et al. ( 2022 ) . THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS . GASTROENTEROLOGY . vol. 162 , S332 - S332 .
Lin M-L, Hickey JW, Schürch CM, Carlotti E, Passman AM, Hackett RJ, Devkumar S, Evans JA et al. ( 2022 ) . Tu1165: THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS . Gastroenterology vol. 162 , ( 7 ) s - 332 .
Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G et al. ( 2022 ) . Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus . Gastroenterology vol. 162 , ( 4 ) 1197 - 1209.e13 .
Passman A, Haughey M, Carlotti E, Williams M, Cereser B, Lin M, Devkumar S, Gabrield J et al. ( 2021 ) . Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium .
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al. ( 2020 ) . 450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM . Gastroenterology vol. 158 , ( 6 ) s - 1276 .
Passman AM, Haughey MJ, Carlotti E, Williams M, Cereser B, Russo FP, Hoare M, Kocher H et al. ( 2020 ) . CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM . GASTROENTEROLOGY . Conference: AACR vol. 158 , S1276 - S1276 .
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones . Journal of Immunology vol. 204 , ( 9 ) 2374 - 2379 .
Krysov S, Odabashian M, Carlotti E, Araf S, Okosun J, Spada F, Gribben J, Forconi F et al. ( 2020 ) . IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution . Blood vol. 135 , ( 11 ) 834 - 844 .
Passman A, Williams M, Carlotti E, Cereser B, Hoare M, Russo F, Kocher HM, Chin-Aleong J et al. ( 2019 ) . The Cell of Origin of Normal Human Hepatocytes has a Common Ancestor with Biliary Epithelium and Hepatocyte Clonal Expansions Arise from the Portal Tract and Drift to the Central Vein . JOURNAL OF PATHOLOGY . vol. 249 , S16 - S16 .
Odabashian M, Carlotti E, Araf S, Okosun J, Forconi F, Stevenson FK, Gribben JG, Calaminici M et al. ( 2018 ) . Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology . Blood . Conference: Search Results Web results ASH Meeting on Lymphoma Biology vol. 132 , 4101 - 4101 .
Evans J, Carlotti E, Williams M, Preston SL, Rodriguez-Justo M, Wright NA, Graham TA, Jansen M et al. ( 2018 ) . 335 - Lineage Tracing in Barrett's Esophagus Reveals both its Origins and Evolution and Suggests that Gland Diversity may be an Important Biomarker for the Progression to Dysplasia in Patients . Gastroenterology vol. 154 , ( 6 ) s - 84 .
Evans J, Carlotti E, Williams M, Preston SL, Rodriguez-Justo M, Wright NA, Graham TA, Jansen M et al. ( 2018 ) . LINEAGE TRACING IN BARRETT'S ESOPHAGUS REVEALS BOTH ITS ORIGINS AND EVOLUTION AND SUGGESTS THAT GLAND DIVERSITY MAY BE AN IMPORTANT BIOMARKER FOR THE PROGRESSION TO DYSPLASIA IN PATIENTS . GASTROENTEROLOGY . vol. 154 , S84 - S84 .
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2016 ) . Next-generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjogren's syndrome . EUROPEAN JOURNAL OF IMMUNOLOGY . Conference: European League Against Rheumatism vol. 46 , 939 - 940 .
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . The role of somatic hypermutation and N-glycosylation in the anti-NET immunoreactivity of RA synovial monoclonal antibodies . EUROPEAN JOURNAL OF IMMUNOLOGY . vol. 46 , 116 - 117 .
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 ,
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2015 ) . Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs . Annals of the Rheumatic Diseases1866 - 1875 .
Murray-Brown W, Carlotti E, Tappuni A, Sutcliffe N, Pitzalis C, Bombardieri M ( 2015 ) . Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome . ARTHRITIS & RHEUMATOLOGY vol. 67 ,
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY vol. 67 ,
Carlotti E, Wrench D, Rosignoli G, Marzec J, Sangaralingam A, Hazanov L, Michaeli M, Hallam S et al. ( 2015 ) . High throughput sequencing analysis of the immunoglobulin heavy chain gene from flow-sorted B cell sub-populations define the dynamics of follicular lymphoma clonal evolution . PLoS ONE vol. 10 , ( 9 )
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 ,
Carlotti E, Floyd J, Murray-Brown W, Barnes M, Mehr R, Bombardieri M, Pitzalis C ( 2015 ) . FRI0008 Longitudinal Analysis of the IGH-VH Gene by High-Throughput Sequencing in Early Rheumatoid Arthritis Paired Biopsies and its Association with Response to Dmards . Annals of the Rheumatic Diseases . vol. 74 ,
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . FRI0020 Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren's Syndrome . Annals of the Rheumatic Diseases . vol. 74 ,
Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Fortune F, Mehr R et al. ( 2015 ) . Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome . SCANDINAVIAN JOURNAL OF IMMUNOLOGY . vol. 81 , 401 - 402 .
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2014 ) . Citrullinated histones from neutrophil extracellular traps (NETs) fuel ectopic germinal centre responses and ACPA production in rheumatoid joints . IMMUNOLOGY vol. 143 , 43 - 43 .
Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M ( 2014 ) . OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets . Annals of the Rheumatic Diseases . vol. 73 ,
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nat Genet vol. 46 , ( 2 ) 176 - 181 .
Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M ( 2014 ) . A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs . Annals of the Rheumatic Diseases . vol. 73 ,
Corsiero E, Bombardieri M, Carlotti E, Wardemann H, Robinson WH, Pitzalis C ( 2013 ) . Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones . ARTHRITIS AND RHEUMATISM . vol. 65 , S1127 - S1128 .
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al. ( 2012 ) . Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma . BLOOD . vol. 120 ,
Wrench D, Leighton P, Skibola CF, Conde L, Cazier J-B, Matthews J, Iqbal S, Carlotti E et al. ( 2011 ) . SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma . Blood vol. 117 , ( 11 ) 3147 - 3150 .
Wrench D, Sangaralingam A, Tayyib H, Kang MK, Riain C, Gupta M, Carlotti E, Bodor C et al. ( 2010 ) . TNERSF14 and EZH2 Mutations, Chr2p Gain and Copy Number Changes Targeting Genes Whose Proteins Interact with the Microenviroment In Transformed Follicular Lymphoma . BLOOD . Conference: 52nd Annual Meeting of the American-Society-of-Hematology (ASH) ( Orlando, FL ) from: 04/12/2010 to: 07/12/2010 , vol. 116 , 349 - 349 .
Wrench D, Sangaralingam A, Tayyib H, Kang MK, Riain C, Gupta M, Carlotti E, Bodor C et al. ( 2010 ) . TNFRSF14 and EZH2 Mutations, Chr2p Gain and Copy Number Changes Targeting Genes Whose Proteins Interact with the Microenvironment In Transformed Follicular Lymphoma . BLOOD . vol. 116 , 349 - 349 .
Wrench J, Skibola C, Matthews J, Cazier JB, Iqbal S, Carlotti E, Calaminici M, Davies A et al. ( 2010 ) . SNP RS6457327 ON CHROMOSOME 6P PREDICTS TRANSFORMATION OF FOLLICULAR LYMPHOMA . HAEMATOLOGICA . vol. 95 , 170 - 171 .
Wrench J, Skibola C, Matthews J, Cazier JB, Iqbal S, Carlotti E, Calaminici M, Davies A et al. ( 2010 ) . SNP RS6457327 ON CHROMOSOME 6P PREDICTS TRANSFORMATION OF FOLLICULAR LYMPHOMA . HAEMATOLOGICA-THE HEMATOLOGY JOURNAL . vol. 95 , 170 - 171 .
Carlotti E, Gribben JG ( 2009 ) . Stem cell mimicry: key to transformation? . Blood vol. 114 , ( 15 ) 3133 - 3134 .
Carlotti E, Wrench D, Matthews J, Iqbal S, Davies A, Norton A, Hart J, Lai R et al. ( 2009 ) . Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone . Blood vol. 113 , ( 15 ) 3553 - 3557 .
Wrench D, Waters R, Carlotti E, Iqbal S, Matthews J, Calaminici M, Gribben J, Lister TA et al. ( 2009 ) . Clinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma . Haematologica vol. 94 , ( 1 ) 148 - 150 .
O'Shea D, O'Riain C, Taylor C, Waters R, Carlotti E, MacDougall F, Gribben J, Rosenwald A et al. ( 2008 ) . The presence of TP53 mutation at diagnosis of follicular lymphoma identifies a high-risk group of patients with shortened time to disease progression and poorer overall survival . BLOOD vol. 112 , ( 8 ) 3126 - 3129 .
Wrench D, Waters R, Matthews J, Calaminici M, Carlotti E, Iqbal S, Gribben J, Lister A et al. ( 2008 ) . MDM2 309 and TP53 ARG72PRO SNP genotypes do not predict clinical outcome of follicular lymphoma . ANNALS OF ONCOLOGY . vol. 19 , 178 - 178 .
Pulsoni A, Della Starza I, Frattarelli N, Carlotti E, Cavalieri E, Ghia E, Matturro A, De Angelis F et al. ( 2008 ) . PCR for BCL-2/IGH+ cells in stage I/II follicular lymphoma identifies positive cells in bone marrow and peripheral blood of the majority of patients, that can be cleared by lymph node irradiation . ANNALS OF ONCOLOGY . vol. 19 , 179 - 179 .
O'Shea D, O'Riain C, Taylor C, Waters R, Carlotti E, MacDougall F, Gribben J, Rosenwald A et al. ( 2008 ) . TP53 MUTATION IDENTIFIES A HIGH RISK GROUP OF PATIENTS AT DIAGNOSIS OF FOLLICULAR LYMPHOMA AND IS ASSOCIATED WITH SHORTER TIME TO DISEASE PROGRESSION AND OVERALL SURVIVAL . HAEMATOLOGICA-THE HEMATOLOGY JOURNAL . vol. 93 , 356 - 356 .
Pulsoni A, Starza ID, Frattarelli N, Carlotti E, Cavalieri E, Matturro A, De Angelis F, Armiento D et al. ( 2008 ) . Use of PCR for BCL2/IgH + cells in stage I/II follicular lymphoma to identify positive cells in bone marrow and peripheral blood that can be cleared by lymph-node irradiation . Journal of Clinical Oncology . vol. 26 , 8571 - 8571 .
Carlotti E, Wrench D, Iqbal S, O’Shea D, Davies A, Virappane P, Hart J, Lai R et al. ( 2007 ) . Determining the Mechanism of Transformation of Follicular Lymphoma into Diffuse Large B Cell Lymphoma . Blood vol. 110 , ( 11 ) 181 - 181 .
Carlotti E, Wrench D, Iqbal S, O'Shea D, Davies A, Virappane P, Hart J, Lai R et al. ( 2007 ) . Determining the mechanism of transformation of follicular lymphoma into diffuse large B cell lymphoma . BLOOD . vol. 110 , 61A - 61A .
Carlotti E, Salmoiraghi S, Palumbo GA, Oldani E, Tibullo D, Rossi A, Golay J, Pulsoni A et al. ( 2007 ) . Fc alpha RIIIA and Fc Gamma RIIA polymorphisms do not predict the clinical outcome of follicular non Hodgkin's lymphoma patients treated with sequential CHOP and Rituximab . HAEMATOLOGICA-THE HEMATOLOGY JOURNAL . vol. 92 , 49 - 49 .
Carlotti E, Palumbo GA, Oldani E, Tibullo D, Salmoiraghi S, Rossi A, Golay J, Pulsoni A et al. ( 2007 ) . FcgammaRIIIA and FcgammaRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab . Haematologica vol. 92 , ( 8 ) 1127 - 1130 .
Fitzgibbon J, Iqbal S, Davies A, O'shea D, Carlotti E, Chaplin T, Matthews J, Raghavan M et al. ( 2007 ) . Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma . Leukemia vol. 21 , ( 7 ) 1514 - 1520 .
Pulsoni A, Della Starza I, Frattarelli N, Ghia E, Carlotti E, Cavalieri E, Matturro A, Tempera S et al. ( 2007 ) . Localized follicular lymphoma: Spread of BCL-2/IgH+ cells in the blood and bone marrow from the primary site of disease and possibility of clearance after involved field radiotherapy . HAEMATOLOGICA-THE HEMATOLOGY JOURNAL . vol. 92 , 103 - 103 .
O'Shea D, Iqbal S, Carlotti E, Davies A, Chaplin T, Matthews J, Manoj M, Norton A et al. ( 2007 ) . SNP array profiling of follicular lymphoma reveals novel regions of acquired UPD . HAEMATOLOGICA-THE HEMATOLOGY JOURNAL . vol. 92 , 62 - 62 .
Pulsoni A, Della Starza I, Frattarelli N, Ghia E, Carlotti E, Cavalieri E, Matturro A, Tempera S et al. ( 2007 ) . Stage I/II follicular lymphoma: spread of bcl-2/IgH+ cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy . BRIT J HAEMATOL vol. 137 , ( 3 ) 216 - 220 .
O'Shea D, Iqbal S, Carlotti E, Davies A, Chaplin T, Matthews J, Raghavan M, Norton A et al. ( 2006 ) . aUPD in the clonal evolution of follicular lymphoma . BLOOD . vol. 108 , 585A - 585A .
Carlotti E, Palumbo GA, Oldani E, Acerboni S, Di Raimondo F, Cortelazzo S, Pulsoni A, Barbui T et al. ( 2005 ) . Bone Marrow BCL2/IgH+ Cells at Diagnosis and Not FCGRIIIA Polymorphism Predict Response in Follicular Non-Hodgkin’s Lymphoma Patients Treated with Sequential CHOP and Rituximab . Blood vol. 106 , ( 11 ) 985 - 985 .
Carlotti E, Palumbo GA, Oldani E, Acerboni S, Di Raimondo F, Cortelazzo S, Pulsoni A, Barbui T et al. ( 2005 ) . Bone marrow BCL2/IgH+ cells at diagnosis and not FCGRIIIA polymorphism predict response in follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab . BLOOD . vol. 106 , 289A - 290A .
Cortelazzo S, Rossi A, Carlotti E, Viero P, Rambaldi A, Barbui T ( 2005 ) . The addition of Rituximab to high dose sequential chemotherapy (HDS) programs with autologous transplantation significantly improves the outcome of patients with refractory or relapsed B-cell non Hogkin's lymphoma . BLOOD . vol. 106 , 589A - 590A .
Rambaldi A, Carlotti E, Oldani E, Della Starza I, Baccarani M, Cortelazzo S, Lauria F, Arcaini L et al. ( 2005 ) . Quantitative PCR of bone marrow BCL2/IgH+ cells at diagnosis predicts treatment response and long-term outcome in follicular non-Hodgkin lymphoma . Blood vol. 105 , ( 9 ) 3428 - 3433 .
Rambaldi A, Carlotti E, Baccarani M, Barbui T, Lauria F, Lazzarino M, Mandelli F, Morra E et al. ( 2003 ) . Long term improvement of clinical outcome of follicular lymphoma patients achieving a molecular response after sequential CHOP and rituximab treatment: Predictive value of real time quantitative PCR to identify responding patients . BLOOD . vol. 102 , 409A - 409A .
Carlotti E, Pettenella F, Amaru R, Slater S, Lister TA, Barbui T, Basso G, Cazzaniga G et al. ( 2002 ) . Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia . BRIT J HAEMATOL vol. 118 , ( 4 ) 1011 - 1018 .
Rambaldi A, Lazzari M, Manzoni C, Carlotti E, Arcaini L, Baccarani M, Barbui T, Bernasconi C et al. ( 2002 ) . Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma . BLOOD vol. 99 , ( 3 ) 856 - 862 .
Rambaldi A, Carlotti E, Baccarani M, Barbui T, Dastoli G, Lauria F, Lazzarino M, Mandelli F et al. ( 2001 ) . Monitoring of minimal residual disease after CHOP and Rituximab in previously untreated follicular lymphoma patients . BLOOD vol. 98 , ( 11 ) 603A - 603A .