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Research

Publications: Mr Jonathan Bestwick

Adams A, Tilden W, Bestwick J, Holden D, Bianchi L, Smets I, Giovannoni G, Gnanapavan S ( 2022 ) . The relationship of cerebrospinal fluid neurofilament levels with magnetic resonance imaging lesion location and disease activity in multiple sclerosis . European Journal of Neurology vol. 29 , ( 9 ) 2754 - 2760 .
Telfer P, Bestwick J, Elander J, Osias A, Khalid N, Skene I, Nzouakou R, Challands J et al. ( 2022 ) . A non-injected opioid analgesia protocol for acute pain crisis in adolescents and adults with sickle cell disease . British Journal of Pain vol. 16 , ( 2 ) 179 - 190 .
Simonet C, Bestwick J, Jitlal M, Waters S, Ben-Joseph A, Marshall CR, Dobson R, Marrium S et al. ( 2022 ) . Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population . JAMA Neurology vol. 79 , ( 4 ) 359 - 369 .
Bothongo PLK, Jitlal M, Parry E, Waters S, Foote IF, Watson CJ, Cuzick J, Giovannoni G et al. ( 2022 ) . Dementia risk in a diverse population: A single-region nested case-control study in the East End of London . The Lancet Regional Health - Europe vol. 15 ,
Noyce A ( 2022 ) . The potential utility of smell testing to screen for neurodegenerative disorders . Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare
Noyce A ( 2022 ) . Developing and Assessing a New Web-based Tapping Test for Measuring Distal Movement in Parkinson’s Disease: a Distal Finger Tapping Test . Scientific Reports
Wald NJ, Bestwick JP, Morris JK ( 2022 ) . Multi-marker risk-based screening for prostate cancer . Journal of Medical Screening
Wald N, Bestwick J, Morris J ( 2022 ) . Risk or chance . Journal of Medical Screening
Wald NJ, Bestwick JP, Morris JK ( 2022 ) . ‘Risk or chance’: Authors’ response . Journal of Medical Screening
Bestwick JP, Auger SD, Simonet C, Rees RN, Rack D, Jitlal M, Giovannoni G, Lees AJ et al. ( 2021 ) . Improving estimation of Parkinson’s disease risk—the enhanced PREDICT-PD algorithm . npj Parkinson's Disease vol. 7 , ( 1 )
Dobson R, Baker D, Kang A, Schmierer K, Giovannoni G ( 2021 ) . COVID-19 vaccine response in people with multiple sclerosis . Annals of Neurology
Bestwick J, Auger S, Schrag A, Grosset DG, Kanavou S, Giovannoni G, Lees AJ, Cuzick J et al. ( 2021 ) . Optimising classification of Parkinson’s disease based on motor, olfactory, neuropsychiatric and sleep features . npj Parkinson's Disease
Simonet C, Gill A, Bestwick J, Lees A, Giovannoni G, Schrag A, Noyce A ( 2021 ) . Emerging parkinsonism in the PREDICT-PD cohort after 6-years of follow-up . MOVEMENT DISORDERS . vol. 36 , S78 - S79 .
Simonet C, Galmes M, Lambert C, Rees R, Haque T, Bestwick J, Lees A, Schrag A et al. ( 2021 ) . Slow Motion Analysis of Repetitive Tapping (SMART) test: measuring of Bradykinesia in Recently Diagnosed Parkinson's disease and Idiopathic Anosmia . MOVEMENT DISORDERS . vol. 36 , S577 - S578 .
Jacobs BM, Noyce AJ, Bestwick J, Belete D, Giovannoni G, Dobson R ( 2021 ) . Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study . Neurology(R) neuroimmunology & neuroinflammation vol. 8 , ( 4 )
Chohan H, Senkevich K, Patel RK, Bestwick JP, Jacobs BM, Bandres Ciga S, Gan-Or Z, Noyce AJ ( 2021 ) . Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression . Movement Disorders vol. 36 , ( 6 ) 1420 - 1429 .
Bestwick JP, Auger SD, Simonet C, Rees RN, Rack D, Jitlal M, Giovannoni G, Lees AJ et al. ( 2021 ) . Improving estimation of Parkinson's disease risk-the enhanced PREDICT-PD algorithm . NPJ Parkinsons Dis vol. 7 , ( 1 )
Stiles CE, Lloyd G, Bhattacharyya S, Steeds RP, Boomla K, Bestwick JP, Drake WM ( 2021 ) . Incidence of Cabergoline-Associated Valvulopathy in Primary Care Patients with Prolactinoma Using Hard Cardiac Endpoints . Journal of Clinical Endocrinology and Metabolism vol. 106 , ( 2 ) E711 - E720 .
Simonet C, Galmes MA, Lambert C, Rees RN, Haque T, Bestwick JP, Lees AJ, Schrag A et al. ( 2021 ) . Slow Motion Analysis of Repetitive Tapping (SMART) Test: Measuring Bradykinesia in Recently Diagnosed Parkinson's Disease and Idiopathic Anosmia . Journal of Parkinson's Disease vol. 11 , ( 4 ) 1901 - 1915 .
Bothongo PL, Jitlal M, Parry E, Foote IF, Waters S, Dobson R, Noyce AJ, Bestwick JP et al. ( 2020 ) . Ethnic and socioeconomic determinants of dementia risk: A nested caseā€control study in the population of East London . Alzheimer's & Dementia vol. 16 , ( S10 )
Jacobs B, Noyce A, Bestwick J, Belete D, Giovannoni G, Dobson R ( 2020 ) . Gene-environment interactions in multiple sclerosis: a uk biobank study . MULTIPLE SCLEROSIS JOURNAL . vol. 26 , 367 - 367 .
Jacobs B, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, International Parkinson’s Disease Genomics Consortium (IPDGC) et al. ( 2020 ) . Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank . Journal of Neurology, Neurosurgery and Psychiatry vol. 91 , 1046 - 1054 .
Goodwin G, Li H, Ismail A, Azevedo H, Giovannoni G, Schrag A, Lees A, Cuzick J et al. ( 2020 ) . Assessing the screening performance of three abbreviated smell tests in Parkinson's disease . MOVEMENT DISORDERS . vol. 35 , S652 - S652 .
Simonet C, Schrag A, Bestwick J, Lees A, Noyce A ( 2020 ) . Emerging motor dysfunction in those at-risk of Parkinson's disease: 5-year follow-up of PREDICT-PD participants . MOVEMENT DISORDERS . vol. 35 , S85 - S85 .
Belete D, Jacobs B, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, Nalls M et al. ( 2020 ) . Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank . MOVEMENT DISORDERS . vol. 35 , S74 - S74 .
Drysdale K, Ntuli Y, Bestwick J, Gelson W, Agarwal K, Forton D, Mutimer D, Elsharkawy AM et al. ( 2020 ) . English hepatitis C registry data show high response rates to directly acting anti-virals, even if treatment is not completed . Alimentary Pharmacology and Therapeutics vol. 52 , ( 1 ) 168 - 181 .
Junejo MH, Bestwick J, Rashid T ( 2020 ) . DEFINING A PATIENT REPORTED OUTCOME MEASURE QUESTIONNAIRE FOR MALE-TO-FEMALE GENITAL RECONSTRUCTION SURGERY . JOURNAL OF SEXUAL MEDICINE . vol. 17 , S158 - S158 .
Struga G, Bianchi L, Ammoscato F, Bestwick J, Giovannoni G, Gnanapavan S ( 2020 ) . Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis . EUROPEAN JOURNAL OF NEUROLOGY . vol. 27 , 1143 - 1143 .
Wald D, Hadyanto S, Bestwick J ( 2020 ) . Should Fractional Flow Reserve follow Angiographic Visual Inspection to guide Preventive PCI in STEMI? . European Heart Journal - Quality of Care and Clinical Outcomes
Pernicova I, Kelly S, Ajodha S, Sahdev A, Bestwick JP, Gabrovska P, Akanle O, Ajjan R et al. ( 2020 ) . Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial . Lancet Diabetes and Endocrinology
Wald DS, Bestwick JP, Kelly P ( 2020 ) . The effect of the Montgomery judgment on settled claims against the National Health Service due to failure to inform before giving consent to treatment . QJM vol. 113 , ( 10 ) 721 - 725 .
Wald DS, Bestwick JP ( 2019 ) . Reaching detection targets in familial hypercholesterolaemia: Comparison of identification strategies . Atherosclerosis vol. 293 , 57 - 61 .
Simonet C, Galmes MA, Bestwick J, Schrag A, Lees A, Noyce AJ ( 2019 ) . Slow-Motion Analysis of Repetitive Tapping (SMART): a pilot study of a new measurement of bradykinesia . MOVEMENT DISORDERS . vol. 34 , S926 - S926 .
Orlev A, Abdel-Gadir A, Tait G, Bestwick JP, Almagor Y, Wald D ( 2019 ) . TCT-789 Comparison of Radial With Femoral Access Coronary Angiography in Patients With Previous Coronary Artery Bypass Surgery . Journal of the American College of Cardiology . vol. 74 ,
Wald D, Chambers J, Bestwick J, Wald N ( 2019 ) . Randomized Crossover Trial of Phosphate-binding Medication on Serum Phosphate Levels in Patients With Aortic Stenosis . Clinical Therapeutics: the international peer-reviewed journal of drug therapy
Wald NJ, Bestwick JP, Lau KW, Huttly WJ, Ke W, Cheng R, Old RW ( 2019 ) . A simple method to allow for guanine-cytosine amplification error in prenatal DNA screening for trisomy 18 . Clinica Chimica Acta vol. 496 , 13 - 17 .
Orlev A, Abdel-Gadir A, Tait G, Bestwick J, Wald D ( 2019 ) . Coronary artery bypass angiography: the exception to the radial access rule? . British Journal of Cardiology vol. 26 , ( 3 ) 114 - 118 .
Bestwick JP, Wald N ( 2019 ) . Cost and efficacy comparison of prenatal recall and reflex DNA screening for trisomy 21, 18 and 13 . PLoS One vol. 14 , ( 7 ) e0220053 - e0220053 .
Mullin S, Beavan M, Bestwick J, McNeill A, Proukakis C, Cox T, Hughes D, Mehta A et al. ( 2019 ) . Evolution and clustering of prodromal parkinsonian features in GBA1 carriers . Movement Disorders vol. 34 , ( 9 ) 1365 - 1373 .
Wald NJ, Bestwick JP, Huttly WJ, Aldis J, Borrell A, Goodburn S, Mills I ( 2019 ) . Corrigendum to: Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies (Prenatal Diagnosis, (2018), 38, 13, (1079-1085), 10.1002/pd.5381) . Prenatal Diagnosis vol. 39 , ( 6 ) 489 - 491 .
WALD DAVID, BESTWICK J ( 2019 ) . Ethnic access to child–parent screening for familial hypercholesterolaemia . European Journal of Preventive Cardiology
Morris JK, Tan J, Fryers P, Bestwick J ( 2018 ) . Evaluation of stability of directly standardized rates for sparse data using simulation methods . Population Health Metrics vol. 16 , ( 1 )
Stiles CE, Tetteh-Wayoe ET, Bestwick JP, Steeds RP, Drake WM ( 2018 ) . A Meta-Analysis of the Prevalence of Cardiac Valvulopathy in Patients with Hyperprolactinemia Treated with Cabergoline . Journal of Clinical Endocrinology and Metabolism vol. 104 , ( 2 ) 523 - 538 .
WALD NJ, BESTWICK J, HUTTLY W, Aldis J, Borrell A, Goodburn S, Mills I ( 2018 ) . Prenatal screening for Down syndrome in twin pregnancies: Estimates of screening performance based on 61 affected and 7302 unaffected twin pregnancies . Prenatal Diagnosis
Bloom B, Thomas S, Ahrensberg JM, Weaver R, Fowler A, Bestwick J, Harris T, Pearse R ( 2018 ) . A systematic review and meta-analysis of return to work after mild Traumatic brain injury . Brain Inj1 - 14 .
Auger S, Rack D, Bestwick J, Giovannoni G, Lees A, Schrag A, Noyce A ( 2018 ) . Risk estimation in the years preceding diagnosis of Parkinson's disease in the PREDICT-PD cohort . MOVEMENT DISORDERS . vol. 33 , S773 - S774 .
WALD NJ, LAU KW, BESTWICK J, Old R, HUTTLY W, CHENG R ( 2018 ) . Specifying a Gold-Standard for the validation of fetal fraction estimation in prenatal screening . Clinical Chemistry vol. 64 , ( 9 ) 1394 - 1399 .
BESTWICK JP, HUTTLY W, WALD N ( 2018 ) . Serum marker truncation limits in first trimester antenatal screening for trisomy 18 . Journal of Medical Screening
Wald DS, Tsolaki E, Bestwick JP, Bertazzo S ( 2018 ) . Scanning electron microscopy for blood micro-crystals in aortic stenosis patients . PLoS One vol. 13 , ( 8 ) e0202282 - e0202282 .
Noyce AJ, Dickson J, Rees RN, Bestwick JP, Isaias IU, Politis M, Giovannoni G, Warner TT et al. ( 2018 ) . Dopamine reuptake transporter–single-photon emission computed tomography and transcranial sonography as imaging markers of prediagnostic Parkinson's disease . Movement Disorders vol. 33 , ( 3 ) 478 - 482 .
Wald NJ, Huttly WJ, Bestwick JP, Old R, Morris JK, Cheng R, Aquilina J, Peregrine E et al. ( 2018 ) . Response to Walker . Genet Med
WALD D, Williams S, Bangash F, bestwick J ( 2018 ) . Watchful waiting in aortic stenosis: the problem of acute decompensation . American Journal of Medicine vol. 131 , ( 2 ) 173 - 177 .
WALD D, BESTWICK J ( 2018 ) . Association between serum calcium, serum phosphate and aortic stenosis with implications for prevention . European Journal of Preventive Cardiology vol. 25 , ( 5 ) 551 - 556 .
WALD NJ, Huttly WJ, Bestwick JP, Old R, Morris JK, Cheng R, Aquilina J, Peregrine E et al. ( 2017 ) . Prenatal reflex DNA screening for trisomy 21, 18, and 13 . Genetics in Medicine
Old RW, Bestwick JP, WALD NJ ( 2017 ) . Prenatal maternal plasma DNA screening for cystic fibrosis: A computer modelling study of screening performance . F1000Research Article Manuscript 12849 ,
Noyce A, Dickson J, Bestwick J, Isaias I, Politis M, Giovannoni G, Warner T, Lees A et al. ( 2017 ) . Associations of DAT SPECT and TCS with prodromal features of Parkinson's disease: Results in PREDICT-PD participants . MOVEMENT DISORDERS . vol. 32 ,
Nagy A, Hardaker E, Bestwick J, Giovannoni G, Warner T, Lees A, Schrag A, Noyce A ( 2017 ) . Cognition in the PREDICT-PD Cohort . MOVEMENT DISORDERS . vol. 32 ,
Noyce AJ, Schrag A, Masters JM, Bestwick JP, Giovannoni G, Lees AJ ( 2017 ) . Subtle motor disturbances in PREDICT-PD participants . J Neurol Neurosurg Psychiatry vol. 88 , ( 3 ) 212 - 217 .
Wald DS, Bestwick JP, Wald NJ ( 2017 ) . The authors reply . New England Journal of Medicine vol. 376 , ( 5 ) 499 - 500 .
Noyce AJ, R'Bibo L, Peress L, Bestwick JP, Adams-Carr KL, Mencacci NE, Hawkes CH, Masters JM et al. ( 2017 ) . PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease . Mov Disord vol. 32 , ( 2 ) 219 - 226 .
Bestwick JP, Huttly WJ, Wald NJ ( 2017 ) . Pregnancy-associated plasma protein-A truncation limits in antenatal screening for trisomy 18 . J Med Screen969141316688499 - 969141316688499 .
Bestwick JP, Wald NJ ( 2016 ) . Antenatal reflex DNA screening for trisomy 18 and trisomy 13 in addition to Down's syndrome . J Med Screen vol. 23 , ( 4 ) 171 - 174 .
WALD D, Bestwick J, Morris J, Whyte K, Jenkins L, Wald N ( 2016 ) . Child-Parent Familial Hypercholesterolemia Screening in Primary Care . New England Journal of Medicine vol. 375 , ( 17 ) 1628 - 1637 .
Allen R, Bestwick J, Thangaratinam S, Aquilina J ( 2016 ) . EP17.20: Maternal blood biomarkers, arteriography and uterine artery Doppler (UAD) for the prediction of hypertensive disease in pregnancy . Ultrasound Obstet Gynecol vol. 48 Suppl 1 ,
Bestwick JP, Wald NJ ( 2016 ) . Sequential integrated antenatal screening for down’s syndrome, trisomy 18 and trisomy 13 . Journal of Medical Screening vol. 23 , ( 3 ) 116 - 123 .
Wald DS, Bestwick JP ( 2016 ) . Preventive percutaneous coronary intervention and aspiration thrombectomy-updates in the management of ST-elevation myocardial infarction . J Thorac Dis vol. 8 , ( 8 ) 1908 - 1912 .
Adams-Carr KL, Bestwick JP, Shribman S, Lees A, Schrag A, Noyce AJ ( 2016 ) . Constipation preceding Parkinson's disease: a systematic review and meta-analysis . J Neurol Neurosurg Psychiatry vol. 87 , ( 7 ) 710 - 716 .
Noyce AJ, Schrag A, Masters J, Bestwick JP, Giovannoni G, Lees AJ ( 2016 ) . Blinded video assessment of subtle Parkinsonian signs in PREDICT-PD participants . MOVEMENT DISORDERS . vol. 31 , S506 - S506 .
R'Bibo L, Mencacci NE, Schrag A, Bestwick JP, Peress L, Masters J, Giovannoni G, Lees AJ et al. ( 2016 ) . Exploring association of GBA variants with pre-diagnostic features of PD in the PREDICT-PD cohort: A nested case-control study . MOVEMENT DISORDERS . vol. 31 , S125 - S125 .
Osborne CW, Bestwick J, Giovannoni G, Lees AJ, Schrag A, Noyce A ( 2016 ) . Participant feedback in the PREDICT-PD study . MOVEMENT DISORDERS . vol. 31 , S594 - S594 .
Wald NJ, Bestwick JP ( 2016 ) . Prenatal reflex DNA screening for Down syndrome: Enhancing the screening performance of the initial first trimester test . Prenatal Diagnosis vol. 36 , ( 4 ) 328 - 331 .
Haddow JE, Craig WY, Neveux LM, Palomaki GE, Lambert-Messerlian G, Malone FD, D'Alton ME, Welch K et al. ( 2016 ) . Free thyroxine during early pregnancy and risk for gestational diabetes . PLoS ONE vol. 11 , ( 2 )
Huttly WJ, Bestwick JP, Wald NJ ( 2016 ) . Insulin dependent diabetes mellitus (IDDM) and first trimester markers in prenatal screening for Down syndrome . Prenatal Diagnosis vol. 36 , ( 2 ) 192 - 193 .
Disanto G, Adiutori R, Dobson R, Martinelli V, Costa GD, Runia T, Evdoshenko E, Thouvenot E et al. ( 2016 ) . Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY vol. 87 , ( 2 ) 126 - 129 .
Wald DS, Butt S, Bestwick JP ( 2016 ) . The Reply . American Journal of Medicine vol. 129 , ( 2 )
Wald NJ, Bestwick JP ( 2016 ) . Antenatal reflex DNA screening for down’s syndrome using total instead of free B-hCG in the combined test . Journal of Medical Screening vol. 23 , ( 1 ) 50 - 51 .
Noyce A, Bestwick J, Mencacci N, Hawkes C, Hardy J, Giovannoni G, Lees A, Schrag A ( 2015 ) . PREDICT-PD: Identifying Risk of Parkinson's disease in the Community . MOVEMENT DISORDERS . vol. 30 , 1989 - 1989 .
Masters JM, Bestwick J, Warner TT, Giovannoni G, Proctor GB, Noyce AJ ( 2015 ) . Systematic review and meta-analysis of salivary protein concentration in Parkinson's disease . Movement Disorders vol. 30 , ( 14 ) 1971 - 1972 .
Wald NJ, Huttly WJ, Bestwick JP, Aquilina J, Peregrine E ( 2015 ) . Reflex antenatal DNA screening for Down syndrome . Prenatal Diagnosis vol. 35 , ( 11 ) 1154 - 1154 .
Adams-Carr K, Schrag A, Shribman S, Bestwick J, Lees A, Noyce A ( 2015 ) . CONSTIPATION PRECEDING PARKINSON'S DISEASE–META-ANALYSIS . Journal of Neurology Neurosurgery & Psychiatry . vol. 86 ,
Wald DS, Butt S, Bestwick JP ( 2015 ) . One-way versus two-way text messaging on improving medication adherence: Meta-analysis of randomized trials . American Journal of Medicine vol. 128 , ( 10 ) 1139.e1 - 1139.e5 .
Wald DS, Butt S, Bestwick JP ( 2015 ) . One-way versus two-way text messaging on improving medication adherence: meta-analysis of randomized trials . The American journal of medicine vol. 128 , ( 10 )
Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick JP, Meier U-C et al. ( 2015 ) . Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study . Mult Scler vol. 21 , ( 8 ) 1013 - 1024 .
Bestwick JP, Wald NJ ( 2015 ) . Antenatal screening for Down’s syndrome, trisomy 18, and trisomy 13: Reporting a single screening result for all three . Journal of Medical Screening vol. 22 , ( 2 ) 100 - 105 .
Adams-Carr KL, Schrag A, Shribman S, Bestwick JP, Lees A, Noyce AJ ( 2015 ) . Constipation preceding Parkinson's disease - Systematic review and meta-analysis . MOVEMENT DISORDERS . vol. 30 , S149 - S149 .
Millward CP, Bhagawati D, Chan HW, Bestwick J, Brecknell JE ( 2015 ) . Retrospective observational comparative study of Hemilaminectomy versus Laminectomy for intraspinal tumour resection; Shorter Stays, Lower Analgesic Usage and Less Kyphotic Deformity . British Journal of Neurosurgery vol. 29 , ( 3 ) 390 - 395 .
Noyce AJ, Mencacci NE, Schrag A, Bestwick JP, Giovannoni G, Lees AJ, Hardy J ( 2015 ) . Web-based assessment of Parkinson's prodromal markers identifies GBA variants . Movement Disorders vol. 30 , ( 7 ) 1002 - 1003 .
( 2015 ) . Corrigendum . J Med Screen vol. 22 , ( 1 ) 52 - 54 .
Wald NJ, Bestwick JP ( 2015 ) . Presentation of meta-analysis plots . Journal of Medical Screening vol. 22 , ( 1 ) 49 - 51 .
Wald DS, Bangash FA, Bestwick JP ( 2015 ) . Prevalence of DNA-confirmed familial hypercholesterolaemia in young patients with myocardial infarction . European Journal of Internal Medicine vol. 26 , ( 2 ) 127 - 130 .
Kuhle J, Gaiottino J, Leppert D, Petzold A, Bestwick JP, Malaspina A, Lu CH, Dobson R et al. ( 2015 ) . Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome . Journal of Neurology, Neurosurgery and Psychiatry vol. 86 , ( 3 ) 273 - 279 .
Kuhle J, Gaiottino J, Leppert D, Petzold A, Bestwick JP, Malaspina A, Lu C-H, Dobson R et al. ( 2015 ) . Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome . J Neurol Neurosurg Psychiatry vol. 86 , ( 3 ) 273 - 279 .
Wald NJ, Bestwick JP ( 2015 ) . Performance of antenatal reflex DNA screening for Down’s syndrome . Journal of Medical Screening vol. 22 , ( 4 ) 168 - 174 .
Wald DS, Bestwick JP ( 2015 ) . Preventive percutaneous coronary intervention in ST-elevation myocardial infarction - the primacy of randomised trials . Interventional Cardiology: Reviews, Research, Resources vol. 10 , ( 1 ) 32 - 34 .
Wald DS, Bestwick JP, Raiman L, Brendell R, Wald NJ ( 2014 ) . Randomised trial of text messaging on adherence to cardiovascular preventive treatment (INTERACT Trial) . PLoS ONE vol. 9 , ( 12 )
Wald NJ, Bestwick JP ( 2014 ) . The area under the ROC curve: Is it a valid measure of screening performance? . Journal of Medical Screening vol. 21 , ( 4 )
Taylor PN, Okosieme OE, Murphy R, Hales C, Chiusano E, Maina A, Joomun M, Bestwick JP et al. ( 2014 ) . Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the Controlled Antenatal Thyroid Study . J Clin Endocrinol Metab vol. 99 , ( 11 ) 4291 - 4298 .
Torsney KM, Noyce AJ, Doherty KM, Bestwick JP, Dobson R, Lees AJ ( 2014 ) . Bone health in Parkinson's disease: a systematic review and meta-analysis . J Neurol Neurosurg Psychiatry vol. 85 , ( 10 ) 1159 - 1166 .
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP ( 2014 ) . Correction: Bradykinesia-akinesia incoordination test: Validating an online keyboard test of upper limb function (PLoS ONE (2014) 9, 4 (e96260) DOI: 10.1371/journal.pone.0096260) . PLoS ONE vol. 9 , ( 8 )
Bestwick JP, Huttly WJ, Wald NJ ( 2014 ) . The estimation of median nuchal translucency values between 10 and 14 weeks of pregnancy . J Med Screen vol. 21 , ( 2 ) 110 - 112 .
Torsney KM, Noyce AJ, Doherty KM, Bestwick JP, Dobson R, Lees AJ ( 2014 ) . A systematic review and meta-analysis of fracture risk in Parkinson's disease . MOVEMENT DISORDERS . vol. 29 , S551 - S551 .
Torsney KM, Noyce AJ, Doherty KM, Bestwick JP, Dobson R, Lees AJ ( 2014 ) . Bone health in Parkinson's disease: A systematic review and meta-analysis . MOVEMENT DISORDERS . vol. 29 , S551 - S551 .
Huttly W, Bestwick J, Wald N ( 2014 ) . Effect of smoking status on inhibin-A in second-trimester prenatal screening for Down syndrome . Prenat Diagn vol. 34 , ( 4 ) 406 - 407 .
Bloom BM, Grundlingh J, Bestwick JP, Harris T ( 2014 ) . The role of venous blood gas in the emergency department: a systematic review and meta-analysis . Eur J Emerg Med vol. 21 , ( 2 ) 81 - 88 .
Bestwick JP, John R, Maina A, Guaraldo V, Joomun M, Wald NJ, Lazarus JH ( 2014 ) . Thyroid stimulating hormone and free thyroxine in pregnancy: expressing concentrations as multiples of the median (MoMs) . Clin Chim Acta vol. 430 , 33 - 37 .
Wald NJ, Bestwick JP ( 2014 ) . Is the area under an ROC curve a valid measure of the performance of a screening or diagnostic test? . J Med Screen vol. 21 , ( 1 ) 51 - 56 .
Nalls MA, Saad M, Noyce AJ, Keller MF, Schrag A, Bestwick JP, Traynor BJ, Gibbs JR et al. ( 2014 ) . Genetic comorbidities in Parkinson's disease . HUMAN MOLECULAR GENETICS vol. 23 , ( 3 ) 831 - 841 .
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G ( 2014 ) . Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function . PLoS One vol. 9 , ( 4 )
Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Knowles CH, Hardy J, Giovannoni G, Nageshwaran S et al. ( 2014 ) . PREDICT-PD: Identifying risk of Parkinson's disease in the community: methods and baseline results . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY vol. 85 , ( 1 ) 31 - 37 .
Bestwick JP, Huttly WJ, Morris JK, Wald NJ ( 2014 ) . Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women . PLoS One vol. 9 , ( 2 )
Kuhle J, Plattner K, Bestwick JP, Lindberg RL, Ramagopalan SV, Norgren N, Nissim A, Malaspina A et al. ( 2013 ) . A comparative study of CSF neurofilament light and heavy chain protein in MS . Mult Scler vol. 19 , ( 12 ) 1597 - 1603 .
Kuhle J, Dobson R, Bestwick JP, Topping J, Dalla Costa G, Khademi M, Sombekke M, Killestein J et al. ( 2013 ) . Multivariate clinically isolated syndrome (CIS) risk factor study: towards individual prognosis and treatment indication in CIS . MULTIPLE SCLEROSIS JOURNAL . vol. 19 , 33 - 34 .
Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G, Noyce AJ ( 2013 ) . Bradykinesia-akinesia incoordination test: Validating an online keyboard test of upper limb function . MOVEMENT DISORDERS . vol. 28 , S114 - S114 .
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Detection of trisomy 18 and trisomy 13 using first and second trimester Down's syndrome screening markers . J Med Screen vol. 20 , ( 2 ) 57 - 65 .
Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Knowles C, Hardy J, Giovannoni G, Nageshwaran S et al. ( 2013 ) . PREDICT-PD study: Online screening algorithm identifying Parkinson's disease risk . MOVEMENT DISORDERS . vol. 28 , S389 - S389 .
Raiman L, Wald D, Bestwick J ( 2013 ) . INTERACT Investigation of Text Message Reminders on Adherence to Cardiac Treatment - Pilot Study . CIRCULATION . vol. 127 ,
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Allowing for ethnic group in antenatal screening for Down's syndrome . J Med Screen vol. 20 , ( 1 ) 52 - 54 .
Wald NJ, Bestwick JP, Huttly WJ ( 2013 ) . Improvements in antenatal screening for Down's syndrome . J Med Screen vol. 20 , ( 1 ) 7 - 14 .
Bestwick JP, Huttly WJ, Wald NJ ( 2013 ) . Allowing for ethnic group in antenatal screening for Down's syndrome . JOURNAL OF MEDICAL SCREENING vol. 20 , ( 1 ) 52 - 54 .
Wald NJ, Bestwick JP ( 2013 ) . Incorporating DNA sequencing into current prenatal screening practice for Down's syndrome . PLoS One vol. 8 , ( 3 )
Gaiottino J, Norgren N, Dobson R, Topping J, Nissim A, Malaspina A, Bestwick JP, Monsch AU et al. ( 2013 ) . Increased neurofilament light chain blood levels in neurodegenerative neurological diseases . PLoS One vol. 8 , ( 9 )
Noyce AJ, Bestwick JP, Silveira-Moriyama L, Hawkes CH, Giovannoni G, Lees AJ, Schrag A ( 2012 ) . Meta-analysis of early nonmotor features and risk factors for Parkinson disease . Ann Neurol vol. 72 , ( 6 ) 893 - 901 .
Wald DS, Bestwick JP, Wald NJ ( 2012 ) . Homocysteine as a cause of ischemic heart disease: the door remains open . Clin Chem vol. 58 , ( 10 ) 1488 - 1490 .
Naderi SH, Bestwick JP, Wald DS ( 2012 ) . Adherence to drugs that prevent cardiovascular disease: meta-analysis on 376,162 patients . Am J Med vol. 125 , ( 9 ) 882 - 7.e1 .
Wald NJ, Bestwick JP, Huttly WJ ( 2012 ) . Effect of interrupting prenatal Down syndrome screening due to a large nuchal translucency . Prenat Diagn vol. 32 , ( 7 ) 655 - 661 .
Bestwick JP, Huttly WJ, Wald NJ ( 2012 ) . Unconjugated estriol values between 14 and 22 weeks of gestation in relation to prenatal screening for Down syndrome . Prenatal Diagnosis vol. 32 , ( 7 )
Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, Chiusano E, John R et al. ( 2012 ) . Antenatal Thyroid Screening and Childhood Cognitive Function . OBSTETRICAL & GYNECOLOGICAL SURVEY vol. 67 , ( 6 ) 337 - 338 .
Wald NJ, Bestwick JP, Morris JK ( 2012 ) . Body weight reduction to avoid the excess risk of type 2 diabetes . Br J Gen Pract vol. 62 , ( 599 ) e411 - e414 .
Noyce AJ, Bestwick J, Silveira-Moriyama L, Hawkes CH, Giovannoni G, Lees AJ, Schrag A ( 2012 ) . Risk factors and early non-motor features for Parkinson's disease: A systematic review and meta-analysis . MOVEMENT DISORDERS . vol. 27 , S4 - S4 .
Wald NJ, Bestwick JP, George LM, Wu T, Morris JK ( 2012 ) . Screening for pre-eclampsia using serum placental growth factor and endoglin with Down's syndrome Quadruple test markers . J Med Screen vol. 19 , ( 2 ) 60 - 67 .
Lazarus JH, Bestwick JP, Wald NJ ( 2012 ) . Antenatal Thyroid Screening and Childhood Cognitive Function REPLY . NEW ENGLAND JOURNAL OF MEDICINE vol. 366 , ( 17 ) 1641 - 1641 .
Lazarus JH, Bestwick JP, Wald NJ ( 2012 ) . The authors reply . New England Journal of Medicine vol. 366 , ( 17 )
Noyce A, Silveira-Moriyama L, Lees AJ, Schrag A, Bestwick J, Hawkes CH, Giovannoni G, Hardy J et al. ( 2012 ) . A PILOT STUDY OF AN ALGORITHM DESIGNED TO IDENTIFY PARKINSON'S DISEASE IN THE EARLY, NON-MOTOR PHASE . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY . vol. 83 ,
Noyce A, Bestwick J, Hawkes CH, Knowles CH, Hardy J, Lees AJ, Silveira-Moriyama L, Giovannoni G et al. ( 2012 ) . AN ALGORITHM TO IDENTIFY INDIVIDUALS AT HIGH-RISK OF PARKINSON'S DISEASE IN THE COMMUNITY . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY . vol. 83 ,
Wald NJ, Bestwick JP, Borrell A ( 2012 ) . Adding ductus venosus blood flow as a categorical variable to the Combined and Integrated tests in Down's syndrome screening . J Med Screen vol. 19 , ( 1 ) 49 - 50 .
Bestwick JP, George LM, Wu T, Morris JK, Wald NJ ( 2012 ) . The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia . J Med Screen vol. 19 , ( 1 ) 51 - 54 .
Bestwick JP, Huttly WJ, Wald NJ ( 2012 ) . Unconjugated estriol values between 14 and 22 weeks of gestation in relation to prenatal screening for Down syndrome . Prenat Diagn vol. 32 , ( 3 ) 299 - 301 .
Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, Chiusano E, John R et al. ( 2012 ) . Antenatal thyroid screening and childhood cognitive function . N Engl J Med vol. 366 , ( 6 ) 493 - 501 .
Wald NJ, Bestwick JP, George LM, Huttly WJ ( 2012 ) . Antenatal screening for Down syndrome using serum placental growth factor with the combined, quadruple, serum integrated and integrated tests . PLoS One vol. 7 , ( 10 )
Lazarus JH, Bestwick JP, Wald NJ ( 2012 ) . Reply . European Thyroid Journal vol. 1 , ( 2 )
Wald DS, Kasturiratne A, Godoy A, Ma L, Bestwick JP, Brewer N, Wald NJ ( 2011 ) . Child-parent screening for familial hypercholesterolemia . J Pediatr vol. 159 , ( 5 ) 865 - 867 .
Noyce AJ, Bestwick J, Hawkes CH, Schrag A, Knowles CH, Hardy J, Lees AJ, Giovannoni G et al. ( 2011 ) . A pilot study of an algorithm designed to identify Parkinson's disease in the early, non-motor phase . MOVEMENT DISORDERS . vol. 26 , S54 - S54 .
Noyce AJ, Bestwick J, Hawkes CH, Knowles CH, Hardy J, Lees AJ, Silveira-Moriyama L, Giovannoni G et al. ( 2011 ) . An algorithm to identify individuals at high-risk of Parkinson's disease in the community . MOVEMENT DISORDERS . vol. 26 , S54 - S55 .
Pearce EN, Lazarus JH, Smyth PPA, He X, Dall'amico D, Parkes AB, Burns R, Smith DF et al. ( 2010 ) . Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women . J Clin Endocrinol Metab vol. 95 , ( 7 ) 3207 - 3215 .
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Erratum: Distribution of nuchal translucency in antenatal screening for Down's syndrome (Journal of Medical Screening (2010) 17 (8-12)) . Journal of Medical Screening vol. 17 , ( 2 )
Wald DS, Bestwick JP ( 2010 ) . C-reactive protein measurement and cardiovascular disease . Lancet vol. 375 , ( 9720 )
Abu-Helalah M, Law MR, Bestwick JP, Monson JP, Wald NJ ( 2010 ) . A randomized double-blind crossover trial to investigate the efficacy of screening for adult hypothyroidism . J Med Screen vol. 17 , ( 4 ) 164 - 169 .
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Distribution of nuchal translucency in antenatal screening for Down's syndrome . J Med Screen vol. 17 , ( 1 ) 8 - 12 .
Bestwick JP, Huttly WJ, Wald NJ ( 2010 ) . Evaluation of a proposed mixture model to specify the distributions of nuchal translucency measurements in antenatal screening for Down's syndrome . J Med Screen vol. 17 , ( 1 ) 13 - 18 .
Murugaesu N, Powles T, Bestwick J, Oliver RTD, Shamash J ( 2009 ) . Long-term follow-up of testicular cancer patients shows no predisposition to osteoporosis . Osteoporos Int vol. 20 , ( 9 ) 1627 - 1630 .
Bestwick JP, Wald NJ, Rudnicka AR ( 2009 ) . Cost of Integrated, sequential and contingent prenatal screening for Down’s syndrome . BMJ: British Medical Journal vol. 338 ,
Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ ( 2009 ) . Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials . Am J Med vol. 122 , ( 3 ) 290 - 300 .
Wald NJ, Huttly WJ, Murphy KW, Ali K, Bestwick JP, Rodeck CH ( 2009 ) . Antenatal screening for Down's syndrome using the Integrated test at two London hospitals . J Med Screen vol. 16 , ( 1 ) 7 - 10 .
Wald DS, Bestwick JP ( 2009 ) . Carotid ultrasound screening for coronary heart disease: results based on a meta-analysis of 18 studies and 44,861 subjects . J Med Screen vol. 16 , ( 3 ) 147 - 154 .
Wald DS, Bestwick JP, Morton G, Drummond L, Jenkins N, Khodabakhsh P, Curzen NP ( 2009 ) . Combining carotid intima-media thickness with carotid plaque on screening for coronary heart disease . J Med Screen vol. 16 , ( 3 ) 155 - 159 .
Borrell A, Borobio V, Bestwick JP, Wald NJ ( 2009 ) . Ductus venosus pulsatility index as an antenatal screening marker for Down's syndrome: use with the Combined and Integrated tests . J Med Screen vol. 16 , ( 3 ) 112 - 118 .
Wald DS, Kasturiratne A, Bestwick JP ( 2009 ) . The value of C-reactive protein in screening for future coronary heart disease events . J Med Screen vol. 16 , ( 4 ) 212 - 214 .
Wald DS, Law M, Mills S, Bestwick JP, Morris JK, Wald NJ ( 2008 ) . A 16-week, randomized, double-blind, placebo-controlled, crossover trial to quantify the combined effect of an angiotensin-converting enzyme inhibitor and a beta-blocker on blood pressure reduction . Clin Ther vol. 30 , ( 11 ) 2030 - 2039 .
Wald NJ, Bestwick JP, Canick JA ( 2008 ) . Contingent screening for Down syndrome . Prenat Diagn vol. 28 , ( 8 )
Wald NJ, Huttly WJ, Bestwick JP ( 2008 ) . Inhibin-A concentrations between 14 and 22 weeks of gestation . Prenat Diagn vol. 28 , ( 4 ) 360 - 361 .
Bestwick JP, Huttly WJ, Wald NJ ( 2008 ) . First trimester Down's syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free beta human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency . J Med Screen vol. 15 , ( 4 ) 204 - 206 .
Morris JK, Bestwick J, Wald NJ ( 2008 ) . Multiple-marker screening for Down's syndrome: a method of assessing the statistical robustness of proposed tests . J Med Screen vol. 15 , ( 2 ) 55 - 61 .
Barnes IM, Bestwick JP, Larsen SO ( 2008 ) . Setting truncation limits for marker values in medical screening (vol 14, pg 103, 2007) . JOURNAL OF MEDICAL SCREENING vol. 15 , ( 3 ) 159 - 159 .
Wald DS, Bestwick JP, Wald NJ ( 2007 ) . Familial hypercholesterolaemia: screening needs a fresh approach . BMJ vol. 335 , ( 7628 ) 1007 - 1008 .
Wald DS, Bestwick JP, Wald NJ ( 2007 ) . Screening needs a fresh approach . BMJ vol. 335 , ( 7628 ) 1007 - 1008 .
Wald DS, Bestwick JP, Wald NJ ( 2007 ) . Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis . BMJ vol. 335 , ( 7620 )
Wald NJ, Bestwick JP, Barnes IM, Kellner LH ( 2007 ) . Anomalous marker patterns in Down syndrome screening . Prenat Diagn vol. 27 , ( 2 ) 185 - 186 .
Wald NJ, Bestwick JP, Morris JK ( 2007 ) . Truncation limits for CT marker ratios in prenatal screening for Down syndrome . Prenat Diagn vol. 27 , ( 2 ) 187 - 188 .
Barnes IM, Bestwick JP, Larsen SO ( 2007 ) . Setting truncation limits for marker values in medical screening . J Med Screen vol. 14 , ( 2 ) 103 - 106 .
Huttly WJ, Morris JK, Bestwick JP, Wald NJ, Murphy K, Pandya PP ( 2006 ) . Three stage contingent screening for Down syndrome . Prenat Diagn vol. 26 , ( 12 )
Choudhury TR, Moosa AA, Cushing A, Bestwick J ( 2006 ) . Patients' attitudes towards the presence of medical students during consultations . Med Teach vol. 28 , ( 7 ) e198 - e203 .
Wald NJ, Bestwick JP, Morris JK ( 2006 ) . Cross trimester marker ratios: parameter estimates valid with no inconsistency . PRENATAL DIAGNOSIS vol. 26 , ( 10 ) 994 - 994 .
Wald NJ, Rudnicka AR, Bestwick JP ( 2006 ) . Sequential and contingent prenatal screening for Down syndrome . Prenat Diagn vol. 26 , ( 9 ) 769 - 777 .
Wald NJ, Bestwick JP, Morris JK ( 2006 ) . Cross-trimester marker ratios in prenatal screening for Down syndrome . Prenat Diagn vol. 26 , ( 6 ) 514 - 523 .
WALD NJ, Rodeck C, Hackshaw AK, Walters J, Chitty L, Mackinson AM, Bestwick JP ( 2006 ) . Erratum to First- and second-trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS) (vol 10, pg 56, 2003) . Journal of Medical Screening vol. 13 , 51 - 52 .
Wald NJ, Bestwick JP, Huttly WJ, Morris JK, George LM ( 2006 ) . Validation plots in antenatal screening for Down's syndrome . J Med Screen vol. 13 , ( 4 ) 166 - 171 .