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Research

Publications: Prof Cleo Bishop

Bishop C ( 2022 ) . Current Understanding of the Role of Senescent Melanocytes in Skin Ageing . Biomedicines vol. 10 , ( 12 ) 3111 - 3111 .
Wallis R, Milligan D, Hughes B, Mizen H, López-Domínguez JA, Eduputa U, Tyler EJ, Serrano M et al. ( 2022 ) . Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence . Aging vol. 14 , ( 10 ) 4220 - 4246 .
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S et al. ( 2021 ) . Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function . Frontiers in Neuroscience vol. 15 , 747067 - 747067 .
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al. ( 2021 ) . Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage . Immunity vol. 54 , ( 7 ) 1494 - 1510.e7 .
Tyler EJ, Gutierrez del Arroyo A, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R et al. ( 2021 ) . Early growth response 2 (EGR2) is a novel regulator of the senescence programme . Aging Cell vol. 20 , ( 3 )
Wallis R, Josipovic N, Mizen H, Robles‐Tenorio A, Tyler EJ, Papantonis A, Bishop CL ( 2021 ) . Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype . Journal of Extracellular Vesicles vol. 10 , ( 4 )
Milligan DA, Tyler EJ, Bishop CL ( 2020 ) . Tissue engineering to better understand senescence: Organotypics come of age . Mechanisms of Ageing and Development vol. 190 ,
Wallis R, Mizen H, Bishop CL ( 2020 ) . The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype . Mechanisms of Ageing and Development vol. 189 ,
Avelar RA, Ortega JG, Tacutu R, Tyler EJ, Bennett D, Binetti P, Budovsky A, Chatsirisupachai K et al. ( 2020 ) . A multidimensional systems biology analysis of cellular senescence in aging and disease . Genome Biology vol. 21 , ( 1 )
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M et al. ( 2019 ) . Cellular Senescence: Defining a Path Forward . Cell vol. 179 , ( 4 ) 813 - 827 .
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT ( 2019 ) . Cell Migration Dynamics: High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform (Adv. Biosys. 8/2019) . Advanced Biosystems vol. 3 , ( 8 ) 1970083 - 1970083 .
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT ( 2019 ) . High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform . Advanced Biosystems1900011 - 1900011 .
Lewis A, Nijhuis A, Berti G, Bishop CL, Feakins R, Lindsay JO, Silver A ( 2019 ) . P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease . Journal of Crohn's and Colitis . vol. 13 , s103 - s104 .
Bolland H, McIntyre A, Shams-Nateri A, Bishop C, Silver A ( 2018 ) . eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival . BRITISH JOURNAL OF CANCER . vol. 119 , 23 - 23 .
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C ( 2017 ) . 682 Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotype . Journal of Investigative Dermatology . vol. 137 ,
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al. ( 2017 ) . Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling . Eur Cell Mater vol. 34 , 128 - 141 .
Nijhuis A, Thompson H, Adam J, Parker A, Gammon L, Lewis A, Bundy JG, Tomoyoshi S et al. ( 2017 ) . Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance . Human Molecular Genetics
Nijhuis A, Curciarello R, Mehta S, Feakins R, Bishop CL, Lindsay JO, Silver A ( 2017 ) . MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8 . Cell Tissue Res
Clarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K et al. ( 2016 ) . Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness . Soft Matter vol. 12 , ( 38 ) 7953 - 7958 .
Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK et al. ( 2015 ) . The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans . Genome Biology vol. 16 , ( 1 )
Moore M, Philpott M, Bishop C ( 2015 ) . 52PA siRNA screen to re-activate senescence in basal-like breast cancer . Annals of Oncology vol. 26 , ( suppl_3 ) iii18 - iii18 .
Lewis A, Mehta S, Hanna LN, Rogalski LA, Jeffery R, Nijhuis A, Kumagai T, Biancheri P et al. ( 2015 ) . Low serum levels of microRNA-19 are associated with a stricturing Crohn's disease phenotype . Inflammatory Bowel Diseases vol. 21 , ( 8 ) 1926 - 1934 .
Murray A, Letourneau A, Canzonetta C, Stathaki E, Gimelli S, Sloan-Bena F, Abrehart R, Goh P et al. ( 2015 ) . Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration . STEM CELLS vol. 33 , ( 6 ) 2077 - 2084 .
Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R et al. ( 2014 ) . In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts . Clin Sci (Lond) vol. 127 , ( 5 ) 341 - 350 .
Overhoff MG, Garbe JC, Koh J, Stampfer MR, Beach DH, Bishop CL ( 2014 ) . Cellular senescence mediated by p16INK4A-coupled miRNA pathways . Nucleic acids research vol. 42 , ( 3 ) 1606 - 1618 .
Liu L, Oliveira NMM, Cheney KM, Pade C, Dreja H, Bergin A-MH, Borgdorff V, Beach DH et al. ( 2011 ) . A whole genome screen for HIV restriction factors . Retrovirology vol. 8 ,
Borgdorff V, Lleonart ME, Bishop CL, Fessart D, Bergin AH, Overhoff MG, Beach DH ( 2010 ) . Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1) . Oncogene vol. 29 , ( 15 ) 2262 - 2271 .
Bishop CL, Bergin A-M, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J et al. ( 2010 ) . Primary cilium dependent and independent Hedgehog signaling inhibits p16INK4A . Mol Cell vol. 40 , ( 4 ) 533 - 547 .
Bishop CL, Ulas S, Baena-Gonzalez E, Aro EM, Purton S, Nugent JHA, Maenpaa P ( 2007 ) . The PsbZ subunit of photosystem II in Synechocystis sp PCC 6803 modulates electron flow through the photosynthetic electron transfer chain . PHOTOSYNTH RES vol. 93 , ( 1-3 ) 139 - 147 .
Bishop CL, Ramalho M, Nadkarni N, Kong WM, Higgins CF, Krauzewicz N ( 2006 ) . Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA (vol 26, pg 2583, 2006) . MOL CELL BIOL vol. 26 , ( 10 ) 3997 - 3997 .
Bishop CL, Ramalho M, Nadkarni N, May Kong W, Higgins CF, Krauzewicz N ( 2006 ) . Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA . Mol Cell Biol vol. 26 , ( 7 ) 2583 - 2594 .
Ramalho M, Bishop C, Higgins CF, Krauzewicz J ( 2004 ) . PML nuclear bodies: A site for HDAC repression of VLP mediated gene expression? . JOURNAL OF GENE MEDICINE . vol. 6 , S9 - S10 .
Bishop CL, Purton S, Nugent JHA ( 2003 ) . Molecular analysis of the Chlamydomonas nuclear gene encoding PsbW and demonstration that PsbW is a subunit of photosystem II, but not photosystem I . PLANT MOL BIOL vol. 52 , ( 2 ) 285 - 289 .
Bishop CL, Ramalho M, McBride AA, Higgins CF, Krauzewicz N ( 2003 ) . Understanding transcriptional regulation of exogenously delivered DNA . MOLECULAR THERAPY . vol. 7 , S443 - S443 .
Ramalho M, Bishop CL, Higgins CF, Krauzewicz N ( 2003 ) . Virus-like particles as a model for studying gene delivery . MOLECULAR THERAPY . vol. 7 , S370 - S371 .