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Research

Publications: Dr Caroline Brennan

Evans JR, Torres-Pérez JV, Miletto Petrazzini ME, Riley R, Brennan CH ( 2021 ) . Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio) . Scientific Reports vol. 11 , ( 1 )
Miletto Petrazzini ME, Brennan CH ( 2020 ) . Application of an abstract concept across magnitude dimensions by fish . Scientific Reports vol. 10 , ( 1 )
Ponzoni L, Teh MT, Torres-Perez JV, Brennan CH, Braida D, Sala M ( 2020 ) . Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal . Molecular Neurobiology
García-González J, Ramírez J, Howard DM, Brennan CH, Munroe PB, Keers R ( 2020 ) . The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank . Translational Psychiatry vol. 10 , ( 1 )
Fontana BD, Gibbon AJ, Cleal M, Sudwarts A, Pritchett D, Miletto Petrazzini ME, Brennan CH, Parker MO ( 2020 ) . Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responses . Developmental Psychobiology
Messina A, Potrich D, Schiona I, Sovrano VA, Fraser SE, Brennan CH, Vallortigara G ( 2020 ) . Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular study . Scientific Reports vol. 10 , ( 1 )
Garcia Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, SUDWARTS A, Teh M-T, Busch-Nentwich E et al. ( 2020 ) . Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour . eLife
Miletto Petrazzini ME, Gambaretto L, Dadda M, Brennan C, Agrillo C ( 2020 ) . Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)? . Laterality
Pritchett D, Brennan CH ( 2020 ) . Chapter 7 Classical and operant conditioning in larval zebrafish . Behavioral and Neural Genetics of Zebrafish ,
Garcia-Gonzalez J, De Quadros B, Akkari M, Brennan C ( 2019 ) . BEHAVIOURAL EFFECTS OF DEVELOPMENTAL EXPOSURE TO THE SYNTHETIC CANNABINOID JWH-018 IN WILD TYPE AND DISRUPTED IN SCHIZOPHRENIA 1 (DISC1) MUTANT ZEBRAFISH . EUROPEAN NEUROPSYCHOPHARMACOLOGY . Conference: The XXVIth World Congress of Psychiatric Genetics (WCPG), 11 - 15 October 2018 vol. 29 , 1274 - 1274 .
BRENNAN CH, Brown VJ, Daggett J ( 2018 ) . Food or friends? What motivates zebrafish (Danio rerio) performing a visual discrimination . Behavioural Brain Research vol. 359 ,
Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO, Brennan CH ( 2017 ) . Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential . J Pharmacol Exp Ther vol. 363 , ( 1 ) 66 - 79 .
Brock AJ, Sudwarts A, Parker MO, Brennan CH ( 2017 ) . Zebrafish behavioral models of ageing . The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish ,
Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nat Commun vol. 7 , 12392 - 12392 .
Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A et al. ( 2016 ) . Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes . Nature Communications vol. 7 , 11942 - 11942 .
Raimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T et al. ( 2016 ) . A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion . Scientific Reports vol. 6 , 26142 - 26142 .
Baiamonte M, Parker MO, Vinson GP, Brennan CH ( 2016 ) . Sustained effects of developmental exposure to ethanol on Zebrafish anxiety-like behaviour . PLoS ONE vol. 11 , ( 2 )
Parker MO, Evans AMD, Brock AJ, Combe FJ, Teh MT, Brennan CH ( 2016 ) . Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood . Addiction Biology vol. 21 , ( 1 ) 49 - 60 .
Parker MO, Brock AJ, Sudwarts A, Teh MT, Combe FJ, Brennan CH ( 2015 ) . Developmental role of acetylcholinesterase in impulse control in zebrafish . Frontiers in Behavioral Neuroscience vol. 9 , ( OCTOBER )
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al. ( 2015 ) . Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC . J Natl Cancer Inst vol. 108 , ( 1 )
Wang MY, Brennan CH, Lachlan RF, Chittka L ( 2015 ) . Speed-accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination task . Animal Behaviour vol. 103 , 277 - 283 .
Baiamonte M, Brennan CH, Vinson GP ( 2015 ) . Sustained action of developmental ethanol exposure on the cortisol response to stress in zebrafish larvae and adults . PLoS ONE vol. 10 , ( 4 )
Stewart AM, Ullmann JFP, Norton WHJ, Parker MO, Brennan CH, Gerlai R, Kalueff AV ( 2015 ) . Molecular psychiatry of zebrafish . Mol Psychiatry vol. 20 , ( 1 ) 2 - 17 .
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT, Brennan CH ( 2014 ) . The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development . Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55 , 94 - 100 .
Cicho¿ MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA ( 2014 ) . The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma . Oncogene vol. 33 , ( 32 ) 4185 - 4192 .
Parker MO, Brock AJ, Sudwarts A, Brennan CH ( 2014 ) . Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish . Psychopharmacology (Berl) vol. 231 , ( 13 ) 2671 - 2679 .
Proulx MJ, Parker MO, Tahir Y, Brennan CH ( 2014 ) . Parallel mechanisms for visual search in zebrafish . PLoS One vol. 9 , ( 10 )
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T, Brennan CH ( 2014 ) . The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development . Progress in Neuro-Psychopharmacology and Biological Psychiatry
Parker MO, Brock AJ, Millington ME, Brennan CH ( 2013 ) . Behavioural phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish . Zebrafish vol. 10 , ( 4 ) 466 - 471 .
Vinson GP, Brennan CH ( 2013 ) . Addiction and the adrenal cortex . Endocr Connect vol. 2 , ( 3 ) R1 - R14 .
Parker MO, Brock AJ, Walton RT, Brennan CH ( 2013 ) . The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function . Frontiers in Neural Circuits ( MAR )
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR et al. ( 2013 ) . S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells . Clin Exp Metastasis vol. 30 , ( 3 ) 251 - 264 .
Parker MO, Ife D, Ma J, Pancholi M, Smeraldi F, Straw C, Brennan CH ( 2013 ) . Development and automation of a test of impulse control in zebrafish . Front Syst Neurosci vol. 7 ,
Parker MO, Brennan CH ( 2012 ) . Zebrafish (Danio rerio) models of substance abuse: Harnessing the capabilities . Behaviour vol. 149 , ( 10-12 ) 1037 - 1062 .
PARKER M, BRENNAN CH ( 2012 ) . Low and Moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life . BJOG: an International Journal of Obstetrics and Gynaecology ( 13 ) 1671 - 1672 .
Parker MO, Brennan CH ( 2012 ) . Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life . BJOG vol. 119 , ( 13 ) 1671 - 1672 .
Cogger K, Guasti L, Ashworth R, Brennan C, Beales P, Marion V, King P ( 2012 ) . The role of primary cilia in mouse adrenal and zebrafish interrenal development . Cilia vol. 1 , ( Suppl 1 )
Parker MO, Gaviria J, Haigh A, Millington ME, Brown VJ, Combe FJ, Brennan CH ( 2012 ) . Discrimination reversal and attentional sets in zebrafish (Danio rerio) . Behav Brain Res vol. 232 , ( 1 ) 264 - 268 .
Parker MO, Millington ME, Combe FJ, Brennan CH ( 2012 ) . Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio) . Behav Brain Res vol. 227 , ( 1 ) 73 - 80 .
Parker MO, Millington ME, Combe FJ, Brennan CH ( 2012 ) . Housing conditions differentially affect physiological and behavioural stress responses of zebrafish, as well as the response to anxiolytics . PLoS One vol. 7 , ( 4 )
Wu HH, Brennan C, Ashworth R ( 2011 ) . Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development . BMC Res Notes vol. 4 ,
Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP et al. ( 2011 ) . AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D . Cancer Res vol. 71 , ( 22 ) 7091 - 7102 .
Jobe K, Brennan CH, Motevalli M, Goldup SM, Watkinson M ( 2011 ) . ChemInform Abstract: Modular “Click” Sensors for Zinc and Their Application in vivo . ChemInform vol. 42 , ( 40 ) no - no .
Brock AJ, Takeda A, Brennan C, Walton RT ( 2011 ) . Treatment for tobacco dependence: a potential application for stratified medicine? . PERS MED vol. 8 , ( 5 ) 571 - 579 .
Brennan CH, Parker MO, Millington ME ( 2011 ) . USING ZEBRAFISH TO EXAMINE THE GENETICS OF DRUG SEEKING AND IMPULSIVITY . JOURNAL OF PSYCHOPHARMACOLOGY . vol. 25 , A6 - A6 .
Jobe K, Brennan CH, Motevalli M, Goldup SM, Watkinson M ( 2011 ) . Modular 'click' sensors for zinc and their application in vivo . Chem Commun (Camb) vol. 47 , ( 21 ) 6036 - 6038 .
Brennan CH, Parmar A, Kily LKM, Ananthathevan A, Doshi A, Patel S ( 2011 ) . Conditioned place preference models of drug dependence and relapse to drug seeking: Studies with nicotine and ethanol . Neuromethods vol. 52 , 163 - 179 .
Brennan CH ( 2011 ) . Zebrafish behavioural assays of translational relevance for the study of psychiatric disease . REV NEUROSCIENCE vol. 22 , ( 1 ) 37 - 48 .
Parmar A, Parmar M, Brennan CH ( 2011 ) . Zebrafish conditioned place preference models of drug reinforcement and relapse to drug seeking . Neuromethods vol. 51 , 75 - 84 .
Dumartin L, Whiteman HJ, Weeks ME, Timms JF, Brentnall TA, Bronner MP, Brennan C, Lemoine NR et al. ( 2010 ) . AGR2 Regulates the Invasion of Pancreatic Cancer Cells Through Cathepsins B and D . PANCREAS vol. 39 , ( 8 ) 1318 - 1319 .
Brennan C, Dosch R, Haramis A-P, Luckenbach T, Martinez-Morales J-R, Moro E, Polok B, Ramesh TM et al. ( 2010 ) . Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18–22, 2010 . Zebrafish vol. 7 , ( 3 ) 305 - 310 .
Wu HHT, Brennan C, Ashworth R ( 2009 ) . A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish . JOURNAL OF GENERAL PHYSIOLOGY . vol. 134 , 17A - 17A .
Brennan CH, Chittka A, Barker S, Vinson GP ( 2008 ) . Eph receptors and zonation in the rat adrenal cortex . J Endocrinol vol. 198 , ( 1 ) 185 - 191 .
Kily LJM, Cowe YCM, Hussain O, Patel S, McElwaine S, Cotter FE, Brennan CH ( 2008 ) . Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways . J Exp Biol vol. 211 , ( Pt 10 ) 1623 - 1634 .
Fabes J, Anderson P, Brennan C, Bolsover S ( 2007 ) . Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord . Eur J Neurosci vol. 26 , ( 9 ) 2496 - 2505 .
Fabes J, Anderson P, Yanez-Munoz RJ, Thrasher A, Brennan C, Bolsover S ( 2006 ) . Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion . EUR J NEUROSCI vol. 23 , ( 7 ) 1721 - 1730 .
Brennan C, Mangoli M, Dyer CEF, Ashworth R ( 2005 ) . Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo . J Cell Sci vol. 118 , ( Pt 22 ) 5181 - 5190 .
Ashworth R, Brennan C ( 2005 ) . Use of transgenic zebrafish reporter lines to study calcium signalling in development . Brief Funct Genomic Proteomic vol. 4 , ( 2 ) 186 - 193 .
Auer R, Costagli A, Newland A, Fegan C, Brennan C, Cotter F ( 2005 ) . Zebrafish in vivo modelling of the 11Q23 region of deletion in chronic lymphatic leukaemia . ANNALS OF ONCOLOGY . vol. 16 , 87 - 87 .
Auer RL, Costagli A, Newland AC, Fegan CD, Brennan C, Cotter FE ( 2005 ) . Definition and zebrafish modelling of the 11 q23 critical region of deletion in CLL . BRITISH JOURNAL OF HAEMATOLOGY . vol. 129 , 25 - 26 .
Rodger J, Vitale PN, Tee LBG, King CE, Bartlett CA, Fall A, Brennan C, O'Shea JE et al. ( 2004 ) . EphA/ephrin-A interactions during optic nerve regeneration: restoration of topography and regulation of ephrin-A2 expression . MOL CELL NEUROSCI vol. 25 , ( 1 ) 56 - 68 .
Barrios A, Poole RJ, Durbin L, Brennan C, Holder N, Wilson SW ( 2003 ) . Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis . CURR BIOL vol. 13 , ( 18 ) 1571 - 1582 .
Brennan C, Fabes J ( 2003 ) . Alkaline phosphatase fusion proteins as affinity probes for protein localization studies . Sci STKE vol. 2003 , ( 168 )
Brennan C, Amacher SL, Currie PD ( 2002 ) . Somitogenesis . Results Probl Cell Differ vol. 40 , 271 - 297 .
Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C et al. ( 2001 ) . Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling . DEV BIOL vol. 234 , ( 2 ) 470 - 482 .
Cooke J, Moens C, Roth L, Durbin L, Shiomi K, Brennan C, Kimmel C, Wilson S et al. ( 2001 ) . Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain . Development vol. 128 , ( 4 ) 571 - 580 .
BRENNAN CH ( 2001 ) . Eph Receptor Signalling and Formation of the Somites in Zebrafish . The origin and fate of somites , Editors: Sanders, EJ, Lash, JW, Ordahl, CP , IOS Press. ( Amsterdam ; Oxford ),