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Research

Publications: Dr Paul Armstrong

Mitchell J, Vinokurova M, Lopes-Pires ME, Shala F, Armstrong P, Ahmetaj-Shala B, Elghazouli Y, Liu B et al. ( 2022 ) . Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic protection .
Grech J, Chan MV, Ochin C, Lachapelle A, Thibord F, Schneider Z, Nkambule BB, Armstrong PCJ et al. ( 2022 ) . Serotonin-affecting antidepressant use in relation to platelet reactivity . Clin Pharmacol Ther
Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C et al. ( 2022 ) . Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity . Arterioscler Thromb Vasc Biol vol. 42 , ( 1 ) 49 - 62 .
Armstrong P, Allan H, Kirkby N, Joshi A, Gutmann C, Crescente M, Mitchell J, Mayr M et al. ( 2021 ) . Temporal in vivo platelet labelling in mice reveals age-dependent receptor expression and conservation of specific mRNAs .
Shih CC, Chan MV, Kirkby NS, Vojnovic I, Mitchell JA, Armstrong PC, Warner TD ( 2021 ) . Platelet inhibition by P2Y<inf>12</inf> antagonists is potentiated by adenosine signalling activators . British Journal of Pharmacology vol. 178 , ( 23 ) 4758 - 4771 .
Allan HE, Hayman MA, Marcone S, Chan MV, Edin ML, Maffucci T, Joshi A, Menke L et al. ( 2021 ) . Proteome and functional decline as platelets age in the circulation . Journal of Thrombosis and Haemostasis vol. 19 , ( 12 ) 3095 - 3112 .
Al Moosawi M, Iding A, Armstrong P, Chiasakul T, Campbell R, Casari C, McLintock C, Brazilek R et al. ( 2021 ) . Impact of the COVID-19 pandemic on education and clinical training . Journal of Thrombosis and Haemostasis vol. 19 , ( 9 ) 2099 - 2100 .
Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R et al. ( 2021 ) . Cyclooxygenases and the cardiovascular system . Pharmacology and Therapeutics vol. 217 ,
Armstrong PC, Ferreira PM, Chan MV, Lundberg Slingsby MH, Crescente M, Shih C-C, Kirkby NS, Hobbs AJ et al. ( 2020 ) . Combination of cyclic nucleotide modulators with P2Y<sub>12</sub> receptor antagonists as anti-platelet therapy . Journal of thrombosis and haemostasis : JTH vol. 18 , ( 7 ) 1705 - 1713 .
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al. ( 2020 ) . Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin . The FASEB Journal
Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE et al. ( 2020 ) . Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients . Blood advances vol. 4 , ( 12 ) 2623 - 2630 .
Chan MV, Chen M-H, Barwari T, Huffman JE, Armstrong PC, Hwang S-J, Santer P, Wierer B et al. ( 2020 ) . Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age . Circulation Research
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al. ( 2019 ) . Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox . Circulation Research vol. 125 , ( 9 ) 847 - 854 .
Vulliamy P, Gillespie S, Armstrong P, Allan H, Warner T, Brohi K ( 2019 ) . Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage . Proceedings of the National Academy of Sciences
Patel D, Warner TD, Armstrong PC ( 2019 ) . ICAM-1 contributes to the preferential binding of platelets to classical and intermediate monocyte subsets over neutrophils . BRITISH JOURNAL OF PHARMACOLOGY . Conference: Pharmacology 2018 from: 20/12/2018 to: 18/12/2018 , vol. 176 , 3038 - 3039 .
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al. ( 2019 ) . Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/ thromboxane A<inf>2</inf> . Journal of Clinical Investigation vol. 129 , ( 5 ) 1845 - 1862 .
Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD ( 2019 ) . Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond) . British Journal of Pharmacology vol. 176 , ( 8 ) 988 - 999 .
Mitchell JA, Shala F, Elghazouli Y, Armstrong PC, Vadgama A, Herschman HR, Kirkby NS ( 2018 ) . Renal or Vascular Deletion of COX-2 Increases Thrombotic Tone: Relevance to Cardiovascular Side Effects of Non-Steroidal Anti-Inflammatory Drugs . CIRCULATION . vol. 138 ,
Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M et al. ( 2018 ) . Inhibition of profibrotic microRNA-21 affects platelets and their releasate . JCI insight vol. 3 , ( 21 )
Barwari T, Eminaga S, Lu R, Armstrong PC, Schulte C, Lynch M, Chan MV, Barallobre-Barreiro J et al. ( 2018 ) . Abstract 300: MicroRNA-21 Affects Platelets and Their Releasate: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition . Circulation Research . vol. 123 ,
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B et al. ( 2018 ) . Abstract 4196: Aspirin inhibits metastasis in the intravascular phase through the blockade of COX-1-TXA 2 pathway in platelets . Conference: Tumor Biology4196 - 4196 .
Barwari T, Eminaga S, Armstrong P, Chan M, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. ( 2018 ) . 82 Microrna-21 regulates transforming growth factor beta-1 release from platelets . Heart . Conference: Basic Science vol. 104 ,
Chan MV, Leadbeater PD, Watson SP, Warner TD ( 2018 ) . Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry . Platelets1 - 4 .
Chan MV, Armstrong PC, Warner TD ( 2018 ) . 96-well plate-based aggregometry . Platelets1 - 6 .
Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, CHAN MV, Armstrong PC, Warner TD et al. ( 2018 ) . Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels . Acta Physiol (Oxf)
Chan MV, Barwari T, Huffman D, Armstrong PC, Santer P, Kiechl S, Willeit J, Mayr M et al. ( 2018 ) . Platelet reactivity in an elderly and healthy population . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 , or25 - or22 .
Crescente M, Armstrong PC, Chan MV, Edin ML, Maffucci T, Kirkby NS, Mitchell JA, Zeldin DC et al. ( 2018 ) . Understanding the cardiovascular effects of low dose aspirin by using a platelet COX-1-/- mouse model . Proceedings for Annual Meeting of The Japanese Pharmacological Society . vol. WCP2018 ,
VULLIAMY P, GILLESPIE S, ARMSTRONG P, CHAN M, DAVENPORT R, WARNER T, BROHI K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . Circulation . Conference: American Heart Association Scientific Sessions ( Anaheim, CA ) from: 11/11/2017 to: 15/11/2017 , vol. e448-467 ,
Vulliamy P, Gillespie S, Armstrong PC, Chan MV, Davenport RA, Warner TD, Brohi K ( 2017 ) . Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones . CIRCULATION . vol. 136 , E464 - E464 .
Barwari T, Eminaga S, Armstrong PC, Chan MV, Lu R, Barallobre-Barreiro J, Yin X, Pechlaner R et al. ( 2017 ) . MicroRNA-21 Regulates Transforming Growth Factor Beta-1 Release From Platelets: A Novel Mechanism for the Anti-Fibrotic Effects of MicroRNA-21 Inhibition . CIRCULATION . vol. 136 ,
Mitchell JA, Shala F, Ahmetaj-Shala B, Jiao J, Armstrong PC, Chan MV, Crescente M, Warner TD et al. ( 2017 ) . Novel Tissue-specific Cyclooxygenase-1 Knockout Mice Demonstrate a Dominant Role for Endothelial Cyclooxygenase-1 in Prostacyclin Production . CIRCULATION . vol. 136 ,
Crescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al. ( 2017 ) . PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEM . HEART . Conference: BCS Annual Conference, ‘Cardiology at the Extremes' vol. 103 , A108 - A109 .
Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD ( 2017 ) . Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies . Arterioscler Thromb Vasc Biol vol. 37 , ( 5 ) 949 - 956 .
Hayman M, Armstrong P, Chan M, Warner T ( 2017 ) . Functional Analyses of Reticulated Platelets . FASEB JOURNAL . vol. 31 ,
Ferreira P, Armstrong P, Chan M, Warner T ( 2016 ) . 169 Soluble Guanylate Cyclase Activators as Combination Anti-Platelet Therapy with P2Y12 Inhibitors and PDE Inhibitors: In vivo and Ex vivo Studies . Heart . vol. 102 ,
Knowles R, D’Silva L, Armstrong P, Chan M, Lawrence M, Standford S, Sabre A, Tucker A et al. ( 2016 ) . 186 Platelets as Key Regulators of Fibrin-Clot Architecture as Assessed by Fractal Analysis of Viscoelastic Properties; Effects of Standard Anti-Platelet Therapies . Heart . vol. 102 ,
Knowles R, D’Silva L, Stanford S, Armstrong P, Chan M, Tucker A, Ferreira P, Sabra A et al. ( 2016 ) . INSIGHTS INTO THE ROLE OF PLATELETS IN FIBRIN CLOT FORMATION AND THE EFFICACY OF ANTI-PLATELET THERAPIES . Journal of the American College of Cardiology . vol. 67 ,
Chan MV, Knowles RBM, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PCJ, Mitchell JA et al. ( 2016 ) . P2Y<inf>12</inf> receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation . British Journal of Clinical Pharmacology vol. 81 , ( 4 ) 621 - 633 .
Warner TD, Armstrong PC, Chan MV, Knowles RB ( 2016 ) . The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy . Expert Review of Hematology vol. 9 , ( 3 ) 223 - 225 .
Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K et al. ( 2016 ) . Association of MicroRNAs and YRNAs with platelet function . Circulation Research vol. 118 , ( 3 ) 420 - 432 .
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS et al. ( 2015 ) . Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: Novel explanation of cardiovascular side effects associated with anti-inflammatory drugs" . Circulation vol. 132 , ( 17 ) e213 - e214 .
Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD ( 2015 ) . Drug-free platelets can act as seeds for aggregate formation during antiplatelet therapy . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 35 , ( 10 ) 2122 - 2133 .
Khanna V, Armstrong PCJ, Warner TD, Curzen N ( 2015 ) . Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography . Platelets vol. 26 , ( 7 ) 689 - 692 .
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD ( 2015 ) . Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction . Blood vol. 126 , ( 10 ) e11 - e18 .
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T ( 2015 ) . 158 The Anti-Platelet Effectiveness of P2Y12 Receptor Blockade is Strongly Influenced by the Endothelium-Derived Mediators Nitric Oxide and Prostacyclin . Heart vol. 101 , ( Suppl 4 )
Knowles R, Chan M, Lundberg M, Kirkby N, Shih C-C, Armstrong P, Hayman M, Vojnovic I et al. ( 2015 ) . 213 Synergy between Endothelial Mediators and P2Y12 Receptor Blockade as a Potential Determinant in Tailoring Anti-Platelet Therapy . Heart . vol. 101 ,
Armstrong PC, Warner TD ( 2015 ) . Characterising cell-type interactions following platelet activation in a novel low volume whole blood assay . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 657 - 657 .
Knowles R, Chan M, Hayman M, Armstrong P, Tucker A, Timmis A, Warner T ( 2015 ) . THE ANTI-PLATELET EFFECTIVENESS OF P2Y12 RECEPTOR BLOCKADE IS STRONGLY INFLUENCED BY THE ENDOTHELIUM- DERIVED MEDIATORS NITRIC OXIDE AND PROSTACYCLIN . HEART . vol. 101 , A90 - A91 .
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. ( 2015 ) . The effectiveness of P2Y12 receptor blockade is strongly determined by the presence of endothelial Mediators prostacyclin and nitric oxide . JOURNAL OF THROMBOSIS AND HAEMOSTASIS . vol. 13 , 784 - 784 .
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al. ( 2015 ) . Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs . CIRCULATION vol. 131 , ( 7 ) 633 - U113 .
Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L et al. ( 2015 ) . Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine novel explanation of cardiovascular side effects associated with anti-inflammatory drugs . Circulation . vol. 131 , 633 - 642 .
Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T et al. ( 2015 ) . Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: Monitoring the nasal and systemic immune response using a network biology approach . BMJ Open vol. 5 , ( 1 )
Knowles RB, Chan MV, Armstrong PC, Shih C-C, Hayman MA, Vojnovic I, Tucker AT, Timmis AD et al. ( 2014 ) . The Effectiveness of P2Y12 Receptor Antagonist Therapy is Strongly Determined by Endothelial Mediators of Platelet Function . CIRCULATION . vol. 130 ,
Armstrong PCJ, Hu H, Rivera J, Rigby S, Chen YC, Howden BP, Gardiner E, Peter K ( 2012 ) . Staphylococcal superantigen-like protein 5 induces thrombotic and bleeding complications in vivo: Inhibition by an anti-SSL5 antibody and the glycan Bimosiamose . Journal of Thrombosis and Haemostasis vol. 10 , ( 12 ) 2607 - 2609 .
Wang X, Hagemeyer CE, Hohmann JD, Leitner E, Armstrong PC, Jia F, Olschewski M, Needles A et al. ( 2012 ) . Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice . Circulation vol. 125 , ( 25 ) 3117 - 3126 .
Armstrong PC, Peter K ( 2012 ) . GPIIb/IIIa inhibitors: From bench to bedside and back to bench again . Thrombosis and Haemostasis vol. 107 , ( 5 ) 808 - 814 .
Topcic D, Kim W, Holien JK, Jia F, Armstrong PC, Hohmann JD, Straub A, Krippner G et al. ( 2011 ) . An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 31 , ( 9 ) 2015 - 2023 .
Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD ( 2011 ) . Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse . PLoS ONE vol. 6 , ( 5 )
Hu H, Armstrong PCJ, Khalil E, Chen YC, Straub A, Li M, Soosairajah J, Hagemeyer CE et al. ( 2011 ) . GPVI and GPIBα mediate Staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors . PLoS ONE vol. 6 , ( 4 )
Armstrong PCJ, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD ( 2011 ) . In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation . J Thromb Haemost vol. 9 , ( 3 ) 552 - 561 .
Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD ( 2011 ) . Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing . Platelets vol. 22 , ( 7 ) 485 - 494 .
Warner TD, Armstrong PCJ, Curzen NP, Mitchell JA ( 2010 ) . Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists? . Heart vol. 96 , ( 21 ) 1693 - 1694 .
Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PCJ, Warner TD et al. ( 2010 ) . Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages . BRIT J PHARMACOL vol. 160 , ( 8 ) 1997 - 2007 .
Shinhmar S, Truss N, Armstrong P, Vojnovic I, Warner T ( 2010 ) . Use of a 96-well plate method for the determination of the anti-platelet effectiveness of a novel NO releasing aspirin molecule . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 70 , 303 - 303 .
Armstrong PCJ, Dhanji ARA, Tucker AT, Mitchell JA, Warner TD ( 2010 ) . Reduction of platelet thromboxane A(2) production ex vivo and in vivo by clopidogrel therapy . J THROMB HAEMOST vol. 8 , ( 3 ) 613 - 615 .
Armstrong P, Hu H, Chen Y, Li M, Bassler N, Fu J, Hagemeyer C, Gardner E et al. ( 2010 ) . Staphylococcal Superantigen-like Protein 5 (SSL5), a Prothrombotic Exotoxin of Staphylococcus aureus Infections and Potential Novel Treatment Strategies . Heart Lung and Circulation vol. 19 , s93 - s94 .
Armstrong PCJ, Dhanji AA, Tucker AT, Mitchell JA, Warner TD ( 2009 ) . URINARY 11-DEHYDRO-THROMBOXANE B2 AS A MARKER OF THE ANTI-PLATELET EFFECTS OF CLOPIDOGREL OR ASPIRIN THERAPY IN HEALTHY MALE VOLUNTEERS . HEART . vol. 95 ,
Truss NJ, Armstrong PCJ, Liverani E, Vojnovic I, Warner TD ( 2009 ) . Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods . J THROMB HAEMOST vol. 7 , ( 11 ) 1897 - 1905 .
Armstrong PCJ, Dhanji AR, Truss NJ, Zain ZNM, Tucker AT, Mitchell JA, Warner TD ( 2009 ) . Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness . THROMB HAEMOSTASIS vol. 102 , ( 4 ) 772 - 778 .
Ali FY, Armstrong PCJ, Dhanji ARA, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD ( 2009 ) . Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs . ARTERIOSCL THROM VAS vol. 29 , ( 5 ) 706 - 711 .
Armstrong PCJ, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZNM, Bishop-Bailey D, Paul-Clark MJ et al. ( 2008 ) . Aspirin and the in vitro linear relationship between thromboxane A(2)-mediated platelet aggregation and platelet production of thromboxane A(2) . J THROMB HAEMOST vol. 6 , ( 11 ) 1933 - 1943 .
Zain ZNM, Armstrong PCJ, Pearson NJ, Mitchell JA, Warner TD ( 2008 ) . Evaluation of aspirin inhibition of platelet aggregation induced by combination of collagen and adrenaline in a 96-well plate format . HEART . vol. 94 ,
Armstrong PCJ, Zain ZNM, Truss NJ, Vojnovic I, Bishop-Bailey D, Mitchell JA, Warner TD ( 2008 ) . Linear relationship between platelet aggregation and thromboxane A(2) production . HEART . vol. 94 ,
Truss NJ, Armstrong PCJ, Zain ZN, Ali FY, Warner TD ( 2008 ) . Platelet aggregation after storage of whole blood at 4 degrees C . HEART . vol. 94 ,
Papalia F, Armstrong PCJ, Pearson NJ, Zain ZNM, Ali FY, Vojnovic I, Warner TD ( 2008 ) . Development of a routine test of platelet reactivity . BRITISH JOURNAL OF CLINICAL PHARMACOLOGY . vol. 65 , 979 - 979 .