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Research

Publications: Dr Mark Baker

Austerschmidt LJ, Schottler NI, Miller AM, Baker MD ( 2021 ) . Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light . Scientific Reports vol. 11 , ( 1 )
Hawkes CH, Baker MD, Giovannoni G, Lechner-Scott J, Levy M ( 2021 ) . Melatonin and multiple sclerosis . Multiple Sclerosis and Related Disorders vol. 51 ,
Austerschmidt LJ, Khan A, Plant DO, Richards EMB, Knott S, Baker MD ( 2020 ) . The effects of temperature on the biophysical properties of optic nerve F-fibres . Scientific Reports vol. 10 , ( 1 )
Baker MD, Nassar MA ( 2020 ) . Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels . Pflugers Archiv European Journal of Physiology vol. 472 , ( 7 ) 865 - 880 .
Plant DO, Khan A, Baker MD ( 2019 ) . Modification of rat optic nerve axon excitability by blocking I-h using ZD7288 . British Journal of Pharmacology . Conference: British Pharmacological Society vol. 176 , 2979 - 2980 .
Bode DC, Stanyon HF, Hirani T, Baker MD, Nield J, Viles JH ( 2018 ) . Serum Albumin's Protective Inhibition of Amyloid-β Fibre Formation Is Suppressed by Cholesterol, Fatty Acids and Warfarin . J Mol Biol
BAKER D ( 2017 ) . Big conductance calcium-activated potassium channel openers control spasticity without sedation . British Journal of Pharmcology
BAKER MD, Kanagaratnam M, Pendleton C, Souza DA, Pettit J, Howells J ( 2017 ) . Diuretic sensitive electroneutral Na+ movement and temperature effects on central axons . The Journal of Physiology
BAKER MD ( 2016 ) . Ion Channel Formation by Amyloid-β42 Oligomers but not Amyloid-β40 in Cellular Membranes . Journal of Biological Chemistry
Park SB, Baker MD ( 2016 ) . Too fast: rare neuropathic pain state associated with easy activation of NaV1.9 . J Neurol Neurosurg Psychiatry
Hockley JRF, Tranter MM, McGuire C, Bondouki G, Cibert-Goton V, Thaha MA, Blackshaw L, Michael GJ et al. ( 2016 ) . P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors . Journal of Neuroscience vol. 36 , ( 8 ) Article 26911685 , 2364 - 2376 .
Coates TA, Woolnough O, Masters JM, Asadova G, Chandrakumar C, Baker MD ( 2015 ) . Acute temperature sensitivity in optic nerve axons explained by an electrogenic membrane potential . Pflugers Archiv European Journal of Physiology vol. 467 , ( 11 ) 2337 - 2349 .
Bulmer D, Hockley J, Mcguire C, Cibert-Goton V, Tranter M, Knowles C, Baker M, Mcmurray S et al. ( 2015 ) . Differential roles of voltage-gated sodium channels on visceral afferent excitability to mechanical and inflammatory mediators . NEUROGASTROENTEROLOGY AND MOTILITY vol. 27 , 110 - 110 .
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al. ( 2014 ) . Multiple roles for Na<inf>V</inf>1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli . Pain vol. 155 , ( 10 ) 1962 - 1975 .
Hockley JRF, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN et al. ( 2014 ) . Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli . Pain vol. 155 , ( 10 ) 1962 - 1975 .
Hadavi S, Baker MD, Dobson R ( 2014 ) . Sustained-release fampridine in Multiple Sclerosis . Multiple Sclerosis and Related Disorders vol. 3 , ( 1 ) 17 - 21 .
Baker MD ( 2013 ) . Potential therapeutic mechanism of K<sup>+</sup> channel block for MS . Multiple Sclerosis and Related Disorders vol. 2 , ( 4 ) 270 - 280 .
Bubb KJ, Wen H, Panayiotou CM, Finsterbusch M, Khan FJ, Chan MV, Priestley JV, Baker MD et al. ( 2013 ) . Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A . Hypertension vol. 62 , ( 2 ) 426 - 433 .
Pristerà A, Baker MD, Okuse K ( 2013 ) . Correction: Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability (PLoS ONE) . PLoS ONE vol. 8 , ( 5 )
Cibert-Goton V, Hockley JR, Tranter M, Boundouki G, Baker MD, Bulmer DC ( 2013 ) . A1 and A2A Adenosine Receptor Subtype Selective Agonists Activate Splanchnic Colonic Afferents With a Clear Modulatory Role of Nav1.9 . GASTROENTEROLOGY . vol. 144 , S297 - S297 .
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC ( 2013 ) . Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9 . GASTROENTEROLOGY . vol. 144 , S935 - S935 .
Cibert-Goton V, Hockley JR, Tranter M, Boundouki G, Baker MD, Bulmer DC ( 2013 ) . Sa1746 A1 and A2A Adenosine Receptor Subtype Selective Agonists Activate Splanchnic Colonic Afferents With a Clear Modulatory Role of Nav1.9 . Gastroenterology vol. 144 , ( 5 ) s - 297 .
Hockley JR, Cibert-Goton V, Boundouki G, Wood J, Knowles CH, Baker MD, Winchester W, Bulmer DC ( 2013 ) . Tu2121 Mechanotransduction in Mouse Visceral Afferent Fibres Is Modulated by Nav1.9 . Gastroenterology vol. 144 , ( 5 ) s - 935 .
Lidster K, Jackson SJ, Ahmed Z, Munro P, Coffey P, Giovannoni G, Baker MD, Baker D ( 2013 ) . Neuroprotection in a novel mouse model of multiple sclerosis . PLoS One vol. 8 , ( 11 )
Eijkelkamp N, Linley JE, Baker MD, Minett MS, Cregg R, Werdehausen R, Rugiero F, Wood JN ( 2012 ) . Neurological perspectives on voltage-gated sodium channels . Brain vol. 135 , ( Pt 9 ) 2585 - 2612 .
Hockley J, Mcguire C, Boundouki G, Knowles C, Baker M, Winchester W, Bulmer D ( 2012 ) . P2Y mediated activation of mouse and human sensory nerves: Critical role for Nav1.9 . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 17 - 18 .
Boundouki G, Hockley J, Mcguire C, Knowles C, Aziz Q, Baker M, Bulmer D ( 2012 ) . The role of Nav1.9 in the activation of visceral afferent fibres by human inflammatory supernatants . NEUROGASTROENTEROLOGY AND MOTILITY vol. 24 , 41 - 41 .
Pristera A, Baker MD, Okuse K ( 2012 ) . Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability . PLOS ONE vol. 7 , ( 8 ) Article ARTN e40079 ,
Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, Ahluwalia A ( 2012 ) . 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel . J Biol Chem vol. 287 , ( 17 ) 13868 - 13876 .
Baker MD, Waxman SG ( 2012 ) . Sodium channel slow inactivation and adaptation in C-fibres . JOURNAL OF PHYSIOLOGY-LONDON vol. 590 , ( 7 ) 1513 - 1514 .
Baker MD, Chen Y-C, Shah SU, Okuse K ( 2011 ) . In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons . Mol Cell Neurosci vol. 48 , ( 3 ) 258 - 265 .
Lidster K, Jackson S, Coffey P, Baker M, Garthwaite J, Selwood D, Giovannoni G, Baker D ( 2011 ) . Neuroprotection in a novel optic neuritis model . MULTIPLE SCLEROSIS JOURNAL vol. 17 , S435 - S435 .
Peiris M, Bulmer DC, Baker MD, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q et al. ( 2011 ) . Human visceral afferent recordings: preliminary report . Gut vol. 60 , ( 2 ) 204 - 208 .
Boundouki G, Peiris M, Baker MD, Bulmer DC, Aziz Q, Hobson A, Sinha S, Lee K et al. ( 2010 ) . A novel in vitro model of visceral pain using the human appendix . BRITISH JOURNAL OF SURGERY vol. 97 , 31 - 32 .
Zhao J, Lee M-C, Momin A, Cendan C-M, Shepherd ST, Baker MD, Asante C, Bee L et al. ( 2010 ) . Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds . J Neurosci vol. 30 , ( 32 ) 10860 - 10871 .
Baker MD, Wen H ( 2010 ) . Tethered-toxin debut gets cold reception . J Physiol vol. 588 , ( Pt 10 )
Snape A, Pittaway JF, Baker MD ( 2010 ) . Excitability parameters and sensitivity to anemone toxin ATX-II in rat small diameter primary sensory neurones discriminated by Griffonia simplicifolia isolectin IB4 . J Physiol vol. 588 , ( Pt 1 ) 125 - 137 .
Shao D, Baker MD, Abrahamsen B, Rugiero F, Malik-Hall M, Poon WYL, Cheah KSE, Yao KM et al. ( 2009 ) . A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8 . MOL CELL NEUROSCI vol. 42 , ( 3 ) 219 - 225 .
Baker MD ( 2009 ) . Action potential initiation in unmyelinated afferents comes in from the cold . J Physiol vol. 587 , ( Pt 6 )
Ostman JAR, Nassar MA, Wood JN, Baker MD ( 2008 ) . GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9 . J Physiol vol. 586 , ( 4 ) 1077 - 1087 .
Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N et al. ( 2006 ) . SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes . Neuron vol. 52 , ( 5 ) 767 - 774 .
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mouldt J, Drinkwater R, Baker MD et al. ( 2006 ) . mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits . P NATL ACAD SCI USA vol. 103 , ( 45 ) 17030 - 17035 .
Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB, Wood JN ( 2006 ) . Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice . Mol Pain vol. 2 ,
Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH et al. ( 2006 ) . Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior . J Neurosci vol. 26 , ( 41 ) 10499 - 10507 .
Baker MD ( 2005 ) . Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis . Multiple Sclerosis as A Neuronal Disease ,
Baker MD ( 2005 ) . Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones . J Physiol vol. 567 , ( Pt 3 ) 851 - 867 .
Stirling LC, Forlani G, Baker MD, Wood JN, Matthews EA, Dickenson AH, Nassar MA ( 2005 ) . Nociceptor-specific gene deletion using heterozygous Na(v)1.8-Cre recombinase mice . PAIN vol. 113 , ( 1-2 ) 27 - 36 .
Wood JN, Boorman JP, Okuse K, Baker MD ( 2004 ) . Voltage-gated sodium channels and pain pathways . J Neurobiol vol. 61 , ( 1 ) 55 - 71 .
Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, Wood JN ( 2004 ) . Nociceptor-specific gene deletion reveals a major role for Na(v)1.7 (PN1) in acute and inflammatory pain . P NATL ACAD SCI USA vol. 101 , ( 34 ) 12706 - 12711 .
Wood JN, Baker MD, Okuse K, Stirling LC, Nassar M ( 2004 ) . Voltage-gated sodium channels and pain pathways . FUNDAMENTAL & CLINICAL PHARMACOLOGY vol. 18 , 16 - 16 .
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew LJ, Nassar MA, Okuse K et al. ( 2004 ) . Ion channel activities implicated in pathological pain . Novartis Found Symp vol. 261 , 32 - 40 .
Wood JN, Abrahamsen B, Baker MD, Boorman JD, Donier E, Drew L, Nassar MA, Okuse K et al. ( 2004 ) . Mechanisms of hyperalgesia: Regulation of nociceptor activation and excitability . HYPERALGESIA: MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS . Editors: Brune, K, Handwerker, HO , vol. 30 , 19 - 26 .
Baker MD, Chandra SY, Ding YN, Waxman SG, Wood JN ( 2003 ) . GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones . J PHYSIOL-LONDON vol. 548 , ( 2 ) 373 - 382 .
Malik-Hall M, Poon WYL, Baker MD, Wood JN, Okuse K ( 2003 ) . Sensory neuron proteins interact with the intracellular domains of sodium channel Na(v)1.8 . MOL BRAIN RES vol. 110 , ( 2 ) 298 - 304 .
Kiernan MC, Baker MD, Bostock H ( 2003 ) . Characteristics of late Na+ current in adult rat small sensory neurons . NEUROSCIENCE vol. 119 , ( 3 ) 653 - 660 .
Baker MD, Chandra SY, Wood JN ( 2002 ) . Up-regulation of Na+ current attributed to Na(v)1.9 (NaN) changes firing properties of small diameter sensory neurones . JOURNAL OF PHYSIOLOGY-LONDON . vol. 544 , 74P - 74P .
Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Kong H, Chao MV, Wood JN ( 2002 ) . Annexin II light chain regulates sensory neuron-specific sodium channel expression . Nature vol. 417 , ( 6889 ) 653 - 656 .
Baker MD ( 2002 ) . Electrophysiology of mammalian Schwann cells . PROG BIOPHYS MOL BIO vol. 78 , ( 2-3 ) 83 - 103 .
Okuse K, Malik-Hall M, Baker MD, Poon WYL, Kong H, Chao MV, Wood JN ( 2002 ) . Simulation of adaptive robust estimation procedures in problems of verification of linear-angular measuring instruments . Measurement Techniques vol. 45 , ( 11 ) 1132 - 1137 .
Wood JN, Akopian AN, Baker M, Ding Y, Geoghegan F, Nassar M, Malik-Hall M, Okuse K et al. ( 2002 ) . Sodium channels in primary sensory neurons: relationship to pain states . SODIUM CHANNELS AND NEURONAL HYPEREXCITABILITY vol. 241 , 159 - 172 .
Wood JN, Baker M ( 2001 ) . Voltage-gated sodium channels . Curr Opin Pharmacol vol. 1 , ( 1 ) 17 - 21 .
Baker MD, Wood JN ( 2001 ) . Involvement of Na+ channels in pain pathways . Trends Pharmacol Sci vol. 22 , ( 1 ) 27 - 31 .
BAKER MD, Wood JN ( 2001 ) . Voltage-gated sodium channels . Current Opinion in Pharmacology vol. 21 , 1 - 17 .
Baker MD ( 2000 ) . Axonal flip-flops and oscillators . Trends in Neurosciences vol. 23 , ( 11 ) 514 - 519 .
Baker MD ( 2000 ) . Selective block of late Na<sup>+</sup> current by local anaesthetics in rat large sensory neurones . British Journal of Pharmacology vol. 129 , ( 8 ) 1617 - 1626 .
Baker MD, Bostock H ( 1999 ) . The pH dependence of late sodium current in large sensory neurons . Neuroscience vol. 92 , ( 3 ) 1119 - 1130 .
Baker MD, Bostock H ( 1998 ) . Inactivation of macroscopic late Na<sup>+</sup> current and characteristics of unitary late Na<sup>+</sup> currents in sensory neurons . Journal of Neurophysiology vol. 80 , ( 5 ) 2538 - 2549 .
Baker MD, Bostock H ( 1997 ) . Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture . Journal of Neurophysiology vol. 77 , ( 3 ) 1503 - 1513 .
Baker MD, Ritchie JM ( 1996 ) . Characteristics of type I and type II K<sup>+</sup> channels in rabbit cultured Schwann cells . Journal of Physiology vol. 490 , ( 1 ) 79 - 95 .
Baker MD, Ritchie JM ( 1994 ) . The action of capsaicin on type I delayed rectifier K<sup>+</sup> currents in rabbit Schwann cells . Proceedings of the Royal Society B: Biological Sciences vol. 255 , ( 1344 ) 259 - 265 .
Baker M, Howe JR, Ritchie JM ( 1993 ) . Two types of 4‐aminopyridine‐sensitive potassium current in rabbit Schwann cells . The Journal of Physiology vol. 464 , ( 1 ) 321 - 342 .
Baker M, Bostock H ( 1992 ) . Ectopic activity in demyelinated spinal root axons of the rat . The Journal of Physiology vol. 451 , ( 1 ) 539 - 552 .
Howe JR, Baker M, Ritchie JM ( 1992 ) . On the block of outward potassium current in rabbit Schwann cells by internal sodium ions . Proceedings of the Royal Society B: Biological Sciences vol. 249 , ( 1326 ) 309 - 316 .
Bostock H, Baker M, Grafe P, Reid G ( 1991 ) . Changes in excitability and accommodation of human motor axons following brief periods of ischaemia . The Journal of Physiology vol. 441 , ( 1 ) 513 - 535 .
Bostock H, Baker M, Reid G ( 1991 ) . Changes in excitability of human motor axons underlying post‐ischaemic fasciculations: evidence for two stable states . The Journal of Physiology vol. 441 , ( 1 ) 537 - 557 .
Baker M, Bostock H ( 1989 ) . Depolarization changes the mechanism of accommodation in rat and human motor axons . The Journal of Physiology vol. 411 , ( 1 ) 545 - 561 .
Bostock H, Baker M ( 1988 ) . Evidence for two types of potassium channel in human motor axons in vivo . Brain Research vol. 462 , ( 2 ) 354 - 358 .
Baker M, Bostock H, Grafe P, Martius P ( 1987 ) . Function and distribution of three types of rectifying channel in rat spinal root myelinated axons . The Journal of Physiology vol. 383 , ( 1 ) 45 - 67 .