Publications: Dr Christopher Bell

Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A et al. ( 2024 ) . Fine mapping of candidate effector genes for heart rate . Human Genetics vol. 143 , ( 9-10 ) 1207 - 1221 .

Bell CG ( 2024 ) . Quantifying stochasticity in the aging DNA methylome . Nature Aging vol. 4 , ( 6 ) 755 - 758 .

Bell CG ( 2024 ) . Epigenomic insights into common human disease pathology . Cellular and Molecular Life Sciences vol. 81 , ( 1 )

Maiarù M, Acton RJ, Woźniak EL, Mein CA, Bell CG, Géranton SM ( 2023 ) . A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain . Clinical Epigenetics vol. 15 , ( 1 )

van Duijvenboden S, Ramírez J, Young WJ, Olczak KJ, Ahmed F, Alhammadi MJAY, Pressure ICOB, Bell CG et al. ( 2023 ) . Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension . American Journal of Human Genetics vol. 110 , ( 10 ) 1718 - 1734 .

Saunderson EA, Encabo HH, Devis J, Rouault-Pierre K, Piganeau M, Bell CG, Gribben JG, Bonnet D et al. ( 2023 ) . CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny . Proceedings of the National Academy of Sciences of the United States of America vol. 120 , ( 34 )

McErlean P, Bell CG, Hewitt RJ, Busharat Z, Ogger PP, Ghai P, Albers GJ, Calamita E et al. ( 2021 ) . DNA Methylome Alterations are Associated with Airway Macrophage Differentiation and Phenotype During Lung Fibrosis . Am J Respir Crit Care Med

Acton R, Yuan W, Gao F, Xia Y, Bourne E, Wozniak E, Bell J, Lillycrop K et al. ( 2021 ) . The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation . Nature Communications

Berjawi M, Bell CG ( 2021 ) . The Therapeutic Potential of Epigenome-Modifying Drugs in Cardiometabolic Disease . Current Genetic Medicine Reports1 - 15 .

Lechner M, Schartinger VH, Steele CD, Nei WL, Ooft ML, Schreiber LM, Pipinikas CP, Chung GTY et al. ( 2021 ) . Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy . Nature Communications vol. 12 , ( 1 )

McErlean P, Bell C, Hewitt R, Busharat Z, Ogger P, Ghai P, Albers G, Kingston S et al. ( 2020 ) . Epigenetic alterations underlie airway macrophage differentiation and phenotype during lung fibrosis . Abstract: java.sql.Clob org.hibernate.engine.jdbc.WrappedClob java.io.Serializable ,

Acton R, Yuan W, Gao F, Xia Y, Bourne E, Wozniak E, Bell J, Lillycrop K et al. ( 2019 ) . The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation .

Bell C, Lowe R, Adams P, Baccarelli A, Beck S, Bell J, Christensen B, Gladyshev V et al. ( 2019 ) . DNA methylation aging clocks: challenges and recommendations . Genome Biology Article 249 (2019) ,

Bowler EH, Smith-Vidal A, Lester A, Bell J, Wang Z, Bell CG, Wang Y, Divecha N et al. ( 2019 ) . Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin . Epigenetics1 - 15 .

Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E et al. ( 2019 ) . Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial . Journal of Bone and Mineral Research vol. 34 , ( 2 ) 231 - 240 .

Curtis EM, Titcombe P, Edwards M, Barton S, Tsai P-C, Dennison EM, Bell J, Spector T et al. ( 2018 ) . 090 DNA methylation and its relationship with musculoskeletal health in older adults from the Hertfordshire Cohort Study: findings from an epigenome-wide association study . Rheumatology vol. 57 , ( suppl_3 )

Thurner M, van de Bunt M, Torres JM, Mahajan A, Nylander V, Bennett AJ, Gaulton KJ, Barrett A et al. ( 2018 ) . Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci . eLife vol. 7 ,

Bell CG, Gao F, Yuan W, Roos L, Acton RJ, Xia Y, Bell J, Ward K et al. ( 2018 ) . Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci . Nature Communications vol. 9 , ( 1 )

Curtis EM, Titcombe P, Edwards M, Barton S, Tsai P-C, Dennison EM, Bell J, Spector T et al. ( 2018 ) . DNA METHYLATION AND ITS RELATIONSHIP WITH MUSCULOSKELETAL HEALTH IN OLDER ADULTS FROM THE HERTFORDSHIRE COHORT STUDY: FINDINGS FROM AN EPIGENOME-WIDE ASSOCIATION STUDY . RHEUMATOLOGY . vol. 57 ,

Simner C, Novakovic B, Lillycrop KA, Bell CG, Harvey NC, Cooper C, Saffery R, Lewis RM et al. ( 2017 ) . DNA methylation of amino acid transporter genes in the human placenta . Placenta vol. 60 , 64 - 73 .

Bell CG ( 2017 ) . The Epigenomic Analysis of Human Obesity . Obesity vol. 25 , ( 9 ) 1471 - 1481 .

Acton RJ, Bell CG ( 2017 ) . Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA . AME Medical Journal vol. 2 , ( 8 ) 110 - 110 .

Curtis EM, Murray R, Titcombe P, Cook E, Clarke-Harris R, Costello P, Garratt E, Holbrook JD et al. ( 2017 ) . Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey . Journal of Bone and Mineral Research vol. 32 , ( 10 ) 2030 - 2040 .

Cook E, Curtis EM, Krstic N, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E et al. ( 2017 ) . 157. PERINATAL DNA METHYLATION AT THE RXRA PROMOTER IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL . Rheumatology vol. 56 , ( suppl_2 )

Curtis E, Cook E, Krstic N, D'Angelo S, Crozier S, Moon R, Murray R, Garratt E et al. ( 2017 ) . DNA METHYLATION AT THE RXRA PROMOTER AT BIRTH IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL . OSTEOPOROSIS INTERNATIONAL . vol. 28 , S72 - S73 .

Curtis E, Krstic N, Cook E, D'Angelo S, Crozier S, Moon R, Murray R, Garratt E et al. ( 2017 ) . Maternal gestational vitamin D supplementation alters perinatal <i>RXRA</i> DNA methylation: findings from the MAVIDOS trial . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 32 , S61 - S61 .

Cook E, Curtis EM, Krstic N, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E et al. ( 2017 ) . PERINATAL DNA METHYLATION AT THE RXRA PROMOTER IS ASSOCIATED WITH GESTATIONAL VITAMIN D SUPPLEMENTATION: RESULTS FROM THE MAVIDOS TRIAL . RHEUMATOLOGY . vol. 56 , 112 - 112 .

Curtis E, Titcombe P, Edwards M, Barton S, Tsai P, Dennison E, Bell J, Spector T et al. ( 2017 ) . RELATIONSHIPS BETWEEN DNA METHYLATION AND MUSCULOSKELETAL HEALTH FROM AN EPIGENOME WIDE ASSOCIATION STUDY: THE HERTFORDSHIRE COHORT . OSTEOPOROSIS INTERNATIONAL . vol. 28 , S478 - S479 .

Roos L, Sandling JK, Bell CG, Glass D, Mangino M, Spector TD, Deloukas P, Bataille V et al. ( 2016 ) . Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma . Journal of Investigative Dermatology vol. 137 , ( 4 ) 910 - 920 .

Bell CG ( 2016 ) . Insights in human epigenomic dynamics through comparative primate analysis . Genomics vol. 108 , ( 3-4 ) 115 - 125 .

Bell CG, Xia Y, Yuan W, Gao F, Ward K, Roos L, Mangino M, Hysi PG et al. ( 2016 ) . Novel regional age-associated DNA methylation changes within human common disease-associated loci . Genome Biology vol. 17 , ( 1 )

Livshits G, Gao F, Malkin I, Needhamsen M, Xia Y, Yuan W, Bell CG, Ward K et al. ( 2016 ) . Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins . Journal of Clinical Endocrinology and Metabolism vol. 101 , ( 6 ) 2450 - 2459 .

Maiarù M, Tochiki KK, Cox MB, Annan LV, Bell CG, Feng X, Hausch F, Géranton SM ( 2016 ) . The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling . Science Translational Medicine vol. 8 , ( 325 )

Roos L, van Dongen J, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD, Bell JT ( 2016 ) . Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs . Clinical Epigenetics vol. 8 , ( 1 )

Bell CG ( 2016 ) . Chapter 17 The Emerging Potential for Epigenetic Therapeutics in Noncancer Disorders . Drug Discovery in Cancer Epigenetics , Elsevier

Willemsen G, Ward KJ, Bell CG, Christensen K, Bowden J, Dalgård C, Harris JR, Kaprio J et al. ( 2015 ) . The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium . Twin Research and Human Genetics vol. 18 , ( 6 ) 762 - 771 .

Pipinikas CP, Dibra H, Karpathakis A, Feber A, Novelli M, Oukrif D, Fusai G, Valente R et al. ( 2015 ) . Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours . Endocrine Related Cancer vol. 22 , ( 3 ) l13 - l18 .

Bell CG ( 2015 ) . The emerging potential for epigenetic therapeutics in noncancer disorders . Drug Discovery in Cancer Epigenetics ,

Yuan W, Xia Y, Bell CG, Yet I, Ferreira T, Ward KJ, Gao F, Loomis AK et al. ( 2014 ) . An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins . Nature Communications vol. 5 , ( 1 )

Bell CG, Wilson GA, Butcher LM, Roos C, Walter L, Beck S ( 2014 ) . Human-specific CpG “beacons” identify loci associated with human-specific traits and disease . Epigenetics vol. 7 , ( 10 ) 1188 - 1199 .

Roos L, Spector TD, Bell CG ( 2014 ) . Using epigenomic studies in monozygotic twins to improve our understanding ofcancer . Epigenomics vol. 6 , ( 3 ) 299 - 309 .

Wilson GA, Butcher LM, Foster HR, Feber A, Roos C, Walter L, Woszczek G, Beck S et al. ( 2014 ) . Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases . Genome Medicine vol. 6 , ( 3 )

Bell CG, Wilson GA, Beck S ( 2014 ) . Human-specific CpG beacons identify human-specific prefrontal cortex H3K4me3 chromatin peaks . Epigenomics vol. 6 , ( 1 ) 21 - 31 .

Bell CG ( 2013 ) . Epigenome-Wide Association Studies: Potential Insights into Human Disease . Epigenetics and Complex Traits , Springer Nature

Bell CG ( 2012 ) . Chapter 14 Epigenomic Factors in Human Obesity . Epigenetics in Human Disease , Elsevier

Bell CG ( 2012 ) . Epigenomic Factors in Human Obesity . Epigenetics in Human Disease ,

Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al. ( 2011 ) . Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis . PLOS Genetics . vol. 7 ,

Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, Daunay A, Busato F et al. ( 2011 ) . Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis . PLoS Genet vol. 7 , ( 9 )

Bell CG ( 2011 ) . Accessing and Selecting Genetic Markers from Available Resources . Methods in Molecular Biology vol. 760 , 1 - 17 .

Bell CG ( 2011 ) . Integration of genomic and epigenomic DNA methylation data in common complex diseases by haplotype-specific methylation analysis . Personalized Medicine vol. 8 , ( 3 ) 243 - 251 .

Bell CG, Beck S ( 2010 ) . The epigenomic interface between genome and environment in common complex diseases . Briefings in Functional Genomics vol. 9 , ( 5-6 ) 477 - 485 .

Bell CG, Teschendorff AE, Rakyan VK, Maxwell AP, Beck S, Savage DA ( 2010 ) . Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus . BMC Medical Genomics vol. 3 , ( 1 )

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H et al. ( 2010 ) . Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer . Genome Research vol. 20 , ( 4 ) 440 - 446 .

Bell CG ( 2010 ) . Epigenomic analysis in common complex disease . MUTAGENESIS . vol. 25 , 638 - 638 .

Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendoff AE, Akan P, Stupka E et al. ( 2010 ) . Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus . PLOS One

Bell CG, Beck S ( 2009 ) . Advances in the identification and analysis of allele-specific expression . Genome Medicine vol. 1 , ( 5 )

Bell CG, Wood DR, Cheong SJH, Kwan E, Sinosich M, Delprado W, Baumgart KW ( 2009 ) . Molecular confirmation of pathological specimen integrity in Australasia . Pathology vol. 41 , ( 3 ) 280 - 283 .

Bell CG, Kwan E, Nolan RC, Baumgart KW ( 2008 ) . First molecular confirmation of an Australian case of type III hereditary angioedema . Pathology vol. 40 , ( 1 ) 82 - 83 .

Bell CG, Meyre D, Petretto E, Levy-Marchal C, Hercberg S, Charles MA, Boyle C, Weill J et al. ( 2007 ) . No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases . EUR J HUM GENET vol. 15 , ( 3 ) 320 - 327 .

Taylor PJ, Maroulis S, Mullan GL, Pedersen RL, Baumli A, Elakis G, Piras S, Walsh C et al. ( 2007 ) . Measurement of the clinical utility of a combined mutation detection protocol in carriers of Duchenne and Becker muscular dystrophy . Journal of Medical Genetics vol. 44 , ( 6 ) 368 - 372 .

Roscioli T, Cliffe ST, Bloch DB, Bell CG, Mullan G, Taylor PJ, Sarris M, Wang J et al. ( 2006 ) . Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease . Nature Genetics vol. 38 , ( 6 ) 620 - 622 .

Bell CG, Meyre D, Samson C, Boyle C, Lecoeur C, Tauber M, Jouret BA, Jaquet D et al. ( 2005 ) . Association of melanin-concentrating hormone receptor 15' polymorphism with early-onset extreme obesity . DIABETES vol. 54 , ( 10 ) 3049 - 3055 .

Guérardel A, Barat-Houari M, Vasseur F, Dina C, Vatin V, Clément K, Eberlé D, Vasseur-Delannoy V et al. ( 2005 ) . Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population . BMC Genomic Data vol. 6 , ( 1 )

Bell CG, Walley AJ, Froguel P ( 2005 ) . The genetics of human obesity . Nature Reviews Genetics vol. 6 , ( 3 ) 221 - 234 .

Bell CG, Benzinou M, Siddiq A, Lecoeur C, Dina C, Lemainque A, Clement K, Basdevant A et al. ( 2004 ) . Genome-wide linkage analysis for severe obesity in French Caucasians finds significant susceptibility locus on chromosome 19q . DIABETES vol. 53 , ( 7 ) 1857 - 1865 .