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Research

Publications: Dr Gary Warnes

Chikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al. ( 2022 ) . Retraction: iASPP is a novel autophagy inhibitor in keratinocytes ( J. Cell Sci. (2014) 127 (3079-3093) DOI: 10.1242/jcs.144816) . Journal of Cell Science vol. 135 , ( 14 )
King HW, Orban N, Riches JC, Clear AJ, Warnes G, Teichmann SA, James LK ( 2021 ) . Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics . Science Immunology vol. 6 , ( 56 )
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH et al. ( 2021 ) . Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup> . Autophagy vol. 17 , ( 1 ) 1 - 382 .
Warnes G ( 2020 ) . Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes . Apoptosis vol. 25 , ( 7-8 ) 548 - 557 .
Hannan S, Affandi AHB, Minere M, Jones C, Goh P, Warnes G, Popp B, Trollmann R et al. ( 2020 ) . Differential co-assembly of α1-GABAARs associated with epileptic encephalopathy . The Journal of Neuroscience
King H, Orban N, Riches J, Clear A, Warnes G, Teichmann S, James L ( 2020 ) . Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation .
Gibbons JM, Marno KM, Pike R, Lee WYJ, Jones CE, Ogunkolade BW, Pardieu C, Bryan A et al. ( 2020 ) . HIV-1 accessory protein Vpr interacts with ReaF/RPRD2 to mitigate its antiviral activity . Journal of Virology vol. 94 , ( 4 )
Wan H, Li X, Ahmad U, Huang Y, Uttagomol J, Rehman A, Zhou K, Warnes G et al. ( 2019 ) . Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells . Mechanisms of Ageing and Development
Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N et al. ( 2019 ) . Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) . European Journal of Immunology vol. 49 , ( 10 ) 1457 - 1973 .
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al. ( 2019 ) . The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 . Cell Death and Disease vol. 10 , ( 10 )
Vossenkamper A, Warnes G ( 2019 ) . Flow cytometry reveals the nature of oncotic cells . International Journal of Molecular Sciences vol. 20 , ( 18 )
Popat A, Patel AA, Warnes G ( 2019 ) . A Flow Cytometric Study of ER Stress and Autophagy . Cytometry Part A vol. 95 , ( 6 ) 672 - 682 .
Gibbons J, Marno K, Pike R, Lee J, Jones C, Ogunkolade W, Pardieu C, Warnes G et al. ( 2019 ) . HIV-1 Vpr accessory protein interacts with REAF and mitigates its associated anti-viral activity . Access Microbiology vol. 1 , ( 1A )
Bergamaschi D, Vossenkamper A, Lee WYJ, Wang P, Bochukova E, Warnes G ( 2019 ) . Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death . Apoptosis
Gibbons J, Marno K, Pike R, Lee W-YJ, Jones C, Ogunkolade B, Pardieu C, Bryan A et al. ( 2018 ) . HIV-1 accessory protein Vpr interacts with REAF/RPRD2 to mitigate its antiviral activity .
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teh T, Uttagomol J, Kang A et al. ( 2018 ) . The <i>Pemphigus Vulgaris</i> antigen desmoglein-3 suppresses p53 function via the YAP-Hippo pathway .
Lee HL, Pike R, Chong MHA, Vossenkamper A, Warnes G ( 2018 ) . Simultaneous flow cytometric immunophenotyping of necroptosis, apoptosis and RIP1-dependent apoptosis . Methods vol. 134-135 , 56 - 66 .
PATEL A, WARNES G ( 2018 ) . Cell cycle analysis of ER stress and autophagy . Autophagy Principles, Regulation, and Roles in Disease , Editors: Gorbunov, NV, Schneider, M , Intech ( online ),
James E, Dua P, Warnes G, Meier UC ( 2017 ) . The effect of simvastatin on autophagy in mammalian cells . MULTIPLE SCLEROSIS JOURNAL . vol. 23 , 790 - 790 .
Pantazi E, Gemenetzidis E, Teh MT, Reddy SV, Warnes G, Evagora C, Trigiante G, Philpott MP ( 2017 ) . GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness, and Long-Term Epidermal Regeneration . Journal of Investigative Dermatology vol. 137 , ( 8 ) 1719 - 1730 .
Scott F, Kouassi M-A, Warnes G, Hornsby E, Elahi S, Adedibe M, Goralczyk A, Mannur K et al. ( 2017 ) . Isolation of human gastric interstitial cells of Cajal . NEUROGASTROENTEROLOGY AND MOTILITY . vol. 29 , 127 - 127 .
Sisay S, Lopez L, Mickunas M, Fernández A, Palace J, Warnes G, Lafuente R, Dua P et al. ( 2017 ) . Untreated relapsing remitting multiple sclerosis patients show antibody production against Latent Epstein Barr Virus (EBV) antigens mainly in the periphery and innate immune IL-8 responses preferentially in the CNS . Journal of Neuroimmunology
WARNES G ( 2016 ) . Flow cytometric measurement of autophagy: Get yourself to eat your way out of cancer and neurodegenerative diseases . Science Atals
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, Adachi H, Adams CM et al. ( 2016 ) . Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) . Autophagy vol. 12 , ( 1 ) 1 - 222 .
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, Adachi H, Adams CM et al. ( 2016 ) . Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 . Autophagy vol. 12 , ( 2 )
Warnes G ( 2015 ) . Flow cytometric assays for the study of autophagy . Methods vol. 82 , 21 - 28 .
Sisay S, Rosello A, Henseleit K, Tan M, Marta-caldo M, Dua P, Warnes G, Palace J et al. ( 2014 ) . Unaltered frequency and functionality of CD56bright and CD56dim natural killer cells in untreated relapsing–remitting multiple sclerosis patients . Journal of Neuroimmunology . vol. 275 ,
Chikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al. ( 2014 ) . IASPP is a novel autophagy mudulator in keratinocytes . J Cell Science vol. 127 , ( 14 ) 3079 - 3093 .
( 2014 ) . DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid . Inflammatory Bowel Diseases vol. 20 , ( 4 )
Dua P, Warnes G, Chruch A, Martino D, Baker D, Giovannoni G, Meier UC ( 2014 ) . Functional effects of anti-neuronal antibodies from patients with Tourette's syndrome and disorders associated with streptococcal infection . Neurology Psychiatry and Brain Research vol. 20 , ( 1 ) 17 - 18 .
Chikte S, Panchal N, Warnes G ( 2014 ) . Use of LysoTracker dyes: A flow cytometric study of autophagy . Cytometry Part A vol. 85 , ( 2 ) 169 - 178 .
Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh M-T et al. ( 2014 ) . GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis . Cell Death Dis vol. 5 ,
MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A et al. ( 2014 ) . DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H<inf>2</inf>O<inf>2</inf> in active ulcerative colitis and are modulated by 5-aminosalicylic acid . Inflammatory Bowel Diseases vol. 20 , ( 3 ) 514 - 524 .
Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh MT et al. ( 2014 ) . GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis . Cell death &amp; disease . vol. 5 ,
Warnes G ( 2014 ) . Measurement of autophagy by flow cytometry . Current Protocols in Cytometry ( SUPPL.68 )
Luo J, Lee S, Wu D, Yeh J, Ellamushi H, Wheeler AP, Warnes G, Bo X ( 2013 ) . P2X7 purinoceptors contribute to the death of Schwann cells transplanted into the spinal cord . Cell Death and Disease vol. 4 , ( 10 )
Panchal, N., Chikte, S., Wilbourn, B.R., Meier, U.C., Warnes, G. ( 2013 ) . Flow Cytometric Measurement of Cell Organelle Autophagy . Immunology and Microbiology » "Autophagy - A Double-Edged Sword - Cell Survival or Death?" , Editors: Yannick, B , INTECH
Rosello A, Warnes G, Meier UC ( 2012 ) . Cell death pathways and autophagy in the central nervous system and their involvement in neurodegeneration, immunity and CNS infection: to die or not to die - that is the question . Clin. Exp. Immunol. vol. 168 , ( 1 ) 52 - 57 .
Henseleit KD, Wheeler AP, Warnes G, Braun KM ( 2012 ) . Characterizing the phenotype of murine epidermal progenitor cells: Complementary whole-mount visualization and flow cytometry strategies . Methods in Molecular Biology vol. 916 , 243 - 261 .
Henseleit KD, Wheeler AP, Warnes G, Braun KM ( 2012 ) . Characterizing the phenotype of murine epidermal progenitor cells: complementary whole-mount visualization and flow cytometry strategies . Methods Mol Biol vol. 916 , 243 - 261 .
Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, Walklin HJ, Johnstone JV, Ibrahim NI et al. ( 2011 ) . The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles . Biomaterials vol. 32 , ( 33 ) 8538 - 8547 .
Vossenkämper A, Marchès O, Fairclough PD, Warnes G, Stagg AJ, Lindsay JO, Evans PC, Luong LA et al. ( 2011 ) . Inhibition of NF-kB signaling in human dendritic cells the enterpathogenic Escherichia coli effector protein NIeE . J Immunol vol. 185 , 4118 - 4127 .
Jayasinghe SN, Warnes G, Scotton CJ ( 2011 ) . Bio-electrosprayed living composite matrix implanted into mouse models . Macromolecular Bioscience vol. 11 , ( 10 ) 1364 - 1369 .
WARNES G, Jayasinghe SN, Scotton CJ ( 2011 ) . Bio-electrosprayed living microenvironments implanted into mouse models . Macromolecular Bioscience vol. 11 , ( 10 ) 1364 - 1369 .
WARNES G, Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, Walklin HJ, Johnstone JV et al. ( 2011 ) . The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles . Biomaterials vol. 32 , ( 33 ) 8538 - 8547 .
Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, Walklin H, Johnstone J, Ibrahim N et al. ( 2011 ) . CD95 Targetted Microparticles Enhance Intracellular Drug Delivery and Increase the Efficacy of Paclitaxel Therapy in an Orthotopic Ovarian Cancer Model . JOURNAL OF PATHOLOGY . vol. 224 , S3 - S3 .
Warnes G, Martins S ( 2011 ) . Real-time flow cytometry for the kinetic analysis of oncosis . Cytometry vol. 79A , 181 - 191 .
Pantazi E, Trigiante G, Warnes G, Gemenetzidis E, Teh M-T, Ikram M, Shan L, Lu YJ et al. ( 2010 ) . Overexpression of GLI2 in human keratinocytes results in resistance to ultraviolet B-induced apoptosis and increased chromosomal instability . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 948 - 948 .
Matin RN, Chikh A, Warnes G, Proby CM, Leigh IM, Harwood CA, Bergamaschi D ( 2010 ) . p63 is implicated in apoptotic dysregulation in melanoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 162 , 921 - 921 .
Khoo CP, Valorani MG, Brittan M, Alison MR, Warnes G, Johansson U, Hawa M, Pozzilli P ( 2009 ) . Characterization of endothelial progenitor cells in the NOD mouse as a source for cell therapies . Diabetes/Metabolism Research and Reviews vol. 25 , ( 1 ) 89 - 93 .
Mageed RA, Mletzko S, Varin M, Duchene J, Taher T, Warnes G, Jawad AS, Isenberg DA ( 2009 ) . ALTERED MEMBRANE CD45 ISOFORM EXPRESSION AND INTRACELLULAR SIGNALLING DEFECTS IN B CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(SLE) . RHEUMATOLOGY . vol. 48 , I32 - I32 .
Janes SM, Ofstad TA, Campbell DH, Eddaoudi A, Warnes G, Davies D, Watt FM ( 2009 ) . PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation . Cell Research vol. 19 , ( 3 ) 328 - 339 .
Mletzko S, Varin M-M, Duchene J, Taher T, Warnes G, Isenberg DA, Mageed RA ( 2008 ) . Altered membrane expression levels of distinct CD45RB isoforms are associated with B cell hyperactivity in systemic lupus erythematosus (SLE) . IMMUNOLOGY . vol. 125 , 41 - 41 .
Biggerstaff JP, Weidow B, Dexheimer J, Warnes G, Vidosh J, Patel S, Newman M, Patel P ( 2008 ) . Soluble fibrin inhibits lymphocyte adherence and cytotoxicity against tumor cells: Implications for cancer metastasis and immunotherapy . Clinical and Applied Thrombosis/Hemostasis vol. 14 , ( 2 ) 193 - 202 .
Khoo CP, Valorani MG, Brittan M, Alison MR, Guglielmi C, Warnes G, Johansson U, Hawa MI et al. ( 2007 ) . Isolation, characterisation and prospects of endothelial progenitor cells to aid pancreatic beta cell regeneration . DIABETOLOGIA . vol. 50 , S221 - S222 .
SHEER D, Fisher A, Forshew T, Takousis P, Johonnett P, Azuara V, Warnes G, Williamson J et al. ( 2007 ) . Replication Timing Profile Reflects the Distinct Functional and Genomic Features of the MHC Class II Region . Cell Cycle vol. 6 , 2393 - 2398 .
Martin JE, Jeffries MH, Warnes G, Maula A, Kaler M, Bird MM, Macey M, Ateh DD ( 2007 ) . Immunoprofiling of neurons: mechanisms for the uptake of debris by neurons . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY . vol. 33 , 261 - 261 .
BERGAMASCHI D, Storey A, Akgul B, Ola A, Warnes G, Leverrier S, Garcia-Escudero R, Blight K et al. ( 2007 ) . Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria . Apoptosis vol. 12 , 549 - 60 .
Warnes G, Macey MG ( 2007 ) . Calcium: Cytoplasmic, mitochondria, endoplasmic reticulum, and flux measurements . Flow Cytometry: Principles and Applications ,
Azuara V, Perry P, Sauer S, Spivakov M, Jørgensen HF, John RM, Gouti M, Casanova M et al. ( 2006 ) . Chromatin signatures of pluripotent cell lines . Nature Cell Biology vol. 8 , ( 5 ) 532 - 538 .
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C ( 2004 ) . Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy . Journal of Experimental Medicine vol. 200 , ( 3 ) 277 - 285 .
Allen K, Eddaoudi A, Simpson C, Warnes G, Davies DC ( 2004 ) . The three E's in a ctyometry core facility: Education, education, education . CYTOMETRY PART A . vol. 59A , 157 - 157 .
Perry P, Sauer S, Billon N, Richardson WD, Spivakov M, Warnes G, Livesey FJ, Merkenschlager M et al. ( 2004 ) . A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction . Cell Cycle vol. 3 , ( 12 ) 1619 - 1624 .
Sabbattini P, Lundgren M, Georgiou A, Chow CM, Warnes G, Dillon N ( 2001 ) . Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation . EMBO Journal vol. 20 , ( 11 ) 2812 - 2822 .
Dixon PH, Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C et al. ( 2000 ) . Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: Evidence for a defect in protein trafficking . Human Molecular Genetics vol. 9 , ( 8 ) 1209 - 1217 .
Amirkhosravi A, Meyer T, Warnes G, Amaya M, Malik Z, Biggerstaff JP, Siddiqui FA, Sherman P et al. ( 1998 ) . Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor . Thrombosis and Haemostasis vol. 80 , ( 4 ) 598 - 602 .
Warnes G, Biggerstaff JP, Francis JL ( 1998 ) . Monocyte B7 and Sialyl Lewis X modulates the efficacy of IL-10 down- regulation of LPS-induced monocyte tissue factor in whole blood . British Journal of Haematology vol. 102 , ( 2 ) 588 - 596 .
Amirkhosravi A, Warnes G, Biggerstaff J, Malik Z, May K, Francis JL ( 1997 ) . The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma . Clinical and Experimental Metastasis vol. 15 , ( 4 ) 453 - 461 .
Amirkhosravi A, Biggerstaff JP, Warnes G, Francis DA, Francis JL ( 1996 ) . Determination of tumor cell procoagulant activity by Sonoclot® analysis in whole blood . Thrombosis Research vol. 84 , ( 5 ) 323 - 332 .
Amirkhosravi A, Alexander M, May K, Francis DA, Warnes G, Biggerstaff J, Francis JL ( 1996 ) . The importance of platelets in the expression of monocyte tissue factor antigen measured by a new whole blood flow cytometric assay . Thrombosis and Haemostasis vol. 75 , ( 1 ) 87 - 95 .
Gant VA, Warnes G, Phillips I, Savidge GF ( 1993 ) . The application of flow cytometry to the study of bacterial responses to antibiotics . J Med Microbiol vol. 39 , ( 2 ) 147 - 154 .