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Research

Publications: Dr Louisa Chard

Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Miao J, Chard LS, Wang Z, Wang Y ( 2019 ) . Syrian Hamster as an Animal Model for the Study on Infectious Diseases . Frontiers in Immunology vol. 10 ,
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2018 ) . Erratum: Author Correction: Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (Nature communications (2017) 8 1 (1395)) . Nature communications vol. 9 , ( 1 )
Wang P, Li X, Wang J, Gao D, Li Y, Li H, Chu Y, Zhang Z et al. ( 2017 ) . Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent . Nat Commun vol. 8 , ( 1 ) 1395 - 1395 .
Yuan M, Wang P, Chard LS, Lemoine NR, Wang Y ( 2016 ) . A simple and efficient approach to construct mutant vaccinia virus vectors . Journal of Visualized Experiments vol. 2016 , ( 116 )
Ahmed J, Yuan M, Li Y, Chu Y, Zhang Z, Gao D, Chard LS, Alusi G et al. ( 2015 ) . 420. A Promising Neo-Adjuvant Immuno-Therapeutic Agent for Preventing Cancer Recurrence and Metastasis After Surgery . Molecular Therapy . vol. 23 ,
Yuan M, Gao X, Chard LS, Ali Z, Ahmed J, Li Y, Liu P, Lemoine NR et al. ( 2015 ) . A marker-free system for highly efficient construction of vaccinia virus vectors using CRISPR Cas9 . Molecular Therapy - Methods and Clinical Development vol. 2 ,
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Chard LS, Lemoine NR, Wang Y ( 2015 ) . New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer . OncoImmunology vol. 4 , ( 9 ) 1 - 3 .
Ahmed J, Yuan M, Li Y, Chu Y, Shi H, Chard L, Alusi G, Lemoine N et al. ( 2014 ) . A Novel Tumour Selective Oncolytic Vaccinia Virus Lacking the N1L Gene Enhances the Anti-Tumour Immune Response When Used as an Anticancer Therapeutic . MOLECULAR THERAPY . vol. 22 , S248 - S249 .
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .
Wang P, Jiang G, Chard L, Wang J, Gao D, Cao H, Lemoine NR, Wang Y ( 2012 ) . A Rationally Designed Oncolytic Adenovirus, Ad-TD-IL-12, Cures Pancreatic Cancer in the Immunocompetent Syrian Hamster . MOLECULAR THERAPY . vol. 20 , S131 - S131 .
Hiley CT, Chard L, Lemoine N, Wang Y ( 2011 ) . A novel replication-selective vaccinia virus vector to express diagnostic or therapeutic genes in hypoxic environments . HUMAN GENE THERAPY vol. 22 , ( 10 ) A99 - A100 .
Chard LS, Bailey DS, Dash P, Banyard AC, Barrett T ( 2008 ) . Full genome sequences of two virulent strains of peste-des-petits ruminants virus, the Côte d'Ivoire 1989 and Nigeria 1976 strains . Virus Res vol. 136 , ( 1-2 ) 192 - 197 .
Bailey D, Chard LS, Dash P, Barrett T, Banyard AC ( 2007 ) . Reverse genetics for peste-des-petits-ruminants virus (PPRV): promoter and protein specificities . Virus Res vol. 126 , ( 1-2 ) 250 - 255 .
Bordeleau M-E, Mori A, Oberer M, Lindqvist L, Chard LS, Higa T, Belsham GJ, Wagner G et al. ( 2006 ) . Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A . Nat Chem Biol vol. 2 , ( 4 ) 213 - 220 .
Chard LS, Bordeleau M-E, Pelletier J, Tanaka J, Belsham GJ ( 2006 ) . Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae . J Gen Virol vol. 87 , ( Pt 4 ) 927 - 936 .
Chard LS, Kaku Y, Jones B, Nayak A, Belsham GJ ( 2006 ) . Functional analyses of RNA structures shared between the internal ribosome entry sites of hepatitis C virus and the picornavirus porcine teschovirus 1 Talfan . J Virol vol. 80 , ( 3 ) 1271 - 1279 .
Pisarev AV, Chard LS, Kaku Y, Johns HL, Shatsky IN, Belsham GJ ( 2004 ) . Functional and structural similarities between the internal ribosome entry sites of hepatitis C virus and porcine teschovirus, a picornavirus . J Virol vol. 78 , ( 9 ) 4487 - 4497 .
Kaku Y, Chard LS, Inoue T, Belsham GJ ( 2002 ) . Unique characteristics of a picornavirus internal ribosome entry site from the porcine teschovirus-1 talfan . J Virol vol. 76 , ( 22 ) 11721 - 11728 .