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Research

Publications: Dr Jonas Bystrom

Bystrom J, Taher TE, Henson SM, Gould DJ, Mageed RA ( 2022 ) . Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases . Frontiers in Immunology vol. 13 ,
Clanchy FIL, Borghese F, Bystrom J, Balog A, Penn H, Taylor PC, Stone TW, Mageed RA et al. ( 2022 ) . Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression . Journal of Autoimmunity vol. 128 , 102810 - 102810 .
Callender L, Carroll E, Ketchley-Garrod C, Schroth J, BYSTROM J, Berryman V, Pattrick M, Campbell-Richards D et al. ( 2021 ) . Altered nutrient uptake causes mitochondrial dysfunction in senescent CD8+ EMRA T cells during type 2 diabetes . Frontiers in Aging
Clanchy FIL, Borghese F, Bystrom J, Balog A, Penn H, Hull DN, Wells GMA, Kiriakidis S et al. ( 2021 ) . TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis . Journal of Autoimmunity vol. 118 ,
Al-Bogami M, Bystrom J, Clanchy F, Taher TE, Mangat P, Williams RO, Jawad AS, Mageed RA ( 2021 ) . TNFα inhibitors reduce bone loss in rheumatoid arthritis independent of clinical response by reducing osteoclast precursors and IL-20 . Rheumatology (United Kingdom) vol. 60 , ( 2 ) 947 - 957 .
Taher TE, Bystrom J, Mignen O, Pers JO, Renaudineau Y, Mageed RA ( 2020 ) . CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels . Cellular and Molecular Immunology vol. 17 , ( 11 ) 1201 - 1203 .
Zhuang X, Maione F, Robinson J, Bentley M, Kaul B, Whitworth K, Jumbu N, Jinks E et al. ( 2020 ) . CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth . JCI Insight vol. 5 , ( 19 )
Bystrom J, Taher TE, Mageed RA ( 2020 ) . Metabolic Pathways Underpinning Lymphocyte Differentiation and Responses in Health and Disease . Immunometabolism vol. 2 , ( 3 )
Al-Adhoubi NK, Bystrom J ( 2020 ) . Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies . Lupus961203320903798 - 961203320903798 .
Amin K, Issa SM, Ali KM, Aziz MI, Hama Amieen HM, Bystrom J, Janson C ( 2020 ) . Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis . Clin Mol Allergy vol. 18 ,
Bystrom J, Clanchy FIL, Taher TE, Al-Bogami M, Ong VH, Abraham DJ, Williams RO, Mageed RA ( 2019 ) . Functional and phenotypic heterogeneity of Th17 cells in health and disease . European Journal of Clinical Investigation vol. 49 , ( 1 )
Amin K, Ali K, Saeed A, Rahman H, Bystrom J ( 2018 ) . Hepatic immune response to environmental carcinogens . Pharmacognosy Magazine vol. 14 , ( 58 ) 548 - 548 .
Bystrom J, Clanchy FI, Taher TE, Mangat P, Jawad AS, Williams RO, Mageed RA ( 2018 ) . TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases . Cytokine vol. 101 , 4 - 13 .
Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers J-O, Abraham DJ et al. ( 2017 ) . Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis . Arthritis Rheumatol
Taher TE, Bystrom J, Ong VH, Isenberg DA, Renaudineau Y, Abraham DJ, Mageed RA ( 2017 ) . Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity . Clin Rev Allergy Immunol vol. 53 , ( 2 ) 237 - 264 .
Bystrom J, Clanchy FI, Taher TE, Al-Bogami MM, Muhammad HA, Alzabin S, Mangat P, Jawad AS et al. ( 2017 ) . Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes . Clin Rev Allergy Immunol vol. 53 , ( 2 ) 265 - 276 .
Amin K, Rasool AH, Hattem A, Al-Karboly TA, Taher TE, Bystrom J ( 2017 ) . Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease . World J Gastroenterol vol. 23 , ( 8 ) 1345 - 1352 .
Amin K, Janson C, Bystrom J ( 2016 ) . Role of Eosinophil Granulocytes in Allergic Airway Inflammation Endotypes . Scandinavian Journal of Immunology vol. 84 , ( 2 ) 75 - 85 .
Gilroy DW, Edin ML, De Maeyer RPH, Bystrom J, Newson J, Lih FB, Stables M, Zeldin DC et al. ( 2016 ) . CYP450-derived oxylipins mediate inflammatory resolution . Proceedings of the National Academy of Sciences of USA vol. 113 , ( 23 ) E3240 - E3249 .
Al-Bogami MM, Alkhorayef MA, Bystrom J, Akanle OA, Al-Adhoubi NK, Jawad AS, Mageed RA ( 2015 ) . Favorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate . Saudi Medical Journal vol. 36 , ( 11 ) 1305 - 1311 .
Bystrom J, Taher TE, Muhyaddin MS, Clanchy FI, Mangat P, Jawad AS, Williams RO, Mageed RA ( 2015 ) . Harnessing the Therapeutic Potential of Th17 Cells . Mediators of Inflammation vol. 2015 ,
Bystrom J, Taher T, Al-Bogami M, Alzabin S, Kelly S, Mangat P, Williams R, Jawad A et al. ( 2014 ) . THU0500 Cytokine Production Identifies A Subset of Rheumatoid Arthritis Patients T Lymphocytes That is Associated with Responsiveness to Biologic Anti-TNF-Alpha Agents . Annals of the Rheumatic Diseases . vol. 73 ,
Bystrom J, O'Shea NR ( 2014 ) . Eosinophilic oesophagitis: clinical presentation and pathogenesis . Postgrad Med J vol. 90 , ( 1063 ) 282 - 289 .
Bystrom J, Al-Adhoubi N, Al-Bogami M, Jawad AS, Mageed RA ( 2013 ) . Th17 lymphocytes in respiratory syncytial virus infection . Viruses vol. 5 , ( 3 ) 777 - 791 .
Bystrom J, Thomson SJ, Johansson J, Edin ML, Zeldin DC, Gilroy DW, Smith AM, Bishop-Bailey D ( 2013 ) . Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease? . PLoS One vol. 8 , ( 9 )
Bystrom J, Patel SY, Amin K, Bishop-Bailey D ( 2012 ) . Dissecting the role of eosinophil cationic protein in upper airway disease . Curr Opin Allergy Clin Immunol vol. 12 , ( 1 ) 18 - 23 .
Stables MJ, Shah S, Camon EB, Lovering RC, Newson J, Bystrom J, Farrow S, Gilroy DW ( 2011 ) . Transcriptomic analyses of murine resolution-phase macrophages . Blood vol. 118 , ( 26 ) e192 - e208 .
Bystrom J, Amin K, Bishop-Bailey D ( 2011 ) . Analysing the eosinophil cationic protein--a clue to the function of the eosinophil granulocyte . Respir Res vol. 12 ,
Bystrom J, Wray JA, Sugden MC, Holness MJ, Swales KE, Warner TD, Edin ML, Zeldin DC et al. ( 2011 ) . Endogenous epoxygenases are modulators of monocyte/macrophage activity . PLoS One vol. 6 , ( 10 )
Hou TZ, Bystrom J, Sherlock JP, Qureshi O, Parnell SM, Anderson G, Gilroy DW, Buckley CD ( 2010 ) . A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis . FEBS Lett vol. 584 , ( 18 ) 3955 - 3961 .
Navarro-Xavier RA, Newson J, Silveira VLF, Farrow SN, Gilroy DW, Bystrom J ( 2010 ) . A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties . J Immunol vol. 184 , ( 3 ) 1516 - 1525 .
Bishop-Bailey D, Bystrom J ( 2009 ) . Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation . Pharmacol Ther vol. 124 , ( 2 ) 141 - 150 .
Bystrom J, Evans I, Newson J, Stables M, Toor I, van Rooijen N, Crawford M, Colville-Nash P et al. ( 2008 ) . Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP . Blood vol. 112 , ( 10 ) 4117 - 4127 .
Stables MJ, Newson JS, Bystrom J, Ayoub SS, Gilroy DW ( 2008 ) . COX-1 modulates the inflammatory macrophage phenotype and the host's ability to fight infection . FUND CLIN PHARMACOL vol. 22 , 47 - 47 .
Newson J, Stables M, Bystrom J, Colville-Nash P, Bellingan G, Gilroy D ( 2008 ) . Lymphocyte trafficking at resolution is mediated by PGD2, via iNOS nitroslyation of COX-2 . FUND CLIN PHARMACOL vol. 22 , 23 - 23 .
Bystrom J, Evans I, Newson J, Stables M, Toor I, Crawford M, Colville-Nash P, Farrow S et al. ( 2008 ) . Resolution-phase macrophages possess a unique inflammatory and bactericidal phenotype that is controlled by CAMP . FUND CLIN PHARMACOL vol. 22 , 47 - 47 .
Rajakariar R, Lawrence T, Bystrom J, Hilliard M, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob MM et al. ( 2008 ) . Novel biphasic role for lymphocytes revealed during resolving inflammation . Blood vol. 111 , ( 8 ) 4184 - 4192 .
Trulson A, Byström J, Engström A, Larsson R, Venge P ( 2007 ) . The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications . Clin Exp Allergy vol. 37 , ( 2 ) 208 - 218 .
Byström J, Dyer KD, Ting-De Ravin SS, Naumann N, Stephany DA, Foster PS, Wynn TA, Rosenberg HF ( 2006 ) . Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo . Eur J Haematol vol. 77 , ( 3 ) 181 - 190 .
Jönsson U-B, Byström J, Stålenheim G, Venge P ( 2006 ) . A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP . J Leukoc Biol vol. 79 , ( 4 ) 846 - 851 .
Nitto T, Dyer KD, Mejia RA, Byström J, Wynn TA, Rosenberg HF ( 2004 ) . Characterization of the divergent eosinophil ribonuclease, mEar 6, and its expression in response to Schistosoma mansoni infection in vivo . Genes Immun vol. 5 , ( 8 ) 668 - 674 .
Swartz JM, Byström J, Dyer KD, Nitto T, Wynn TA, Rosenberg HF ( 2004 ) . Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes . J Leukoc Biol vol. 76 , ( 4 ) 812 - 819 .
Nitto T, Dyer KD, Bystrom J, Mejia RA, Wynn TA, Rosenberg HF ( 2004 ) . IL-5 dependent regulation of eosinophil ribonuclease gene expression . FASEB JOURNAL . vol. 18 , A416 - A416 .
Byström J, Wynn TA, Domachowske JB, Rosenberg HF ( 2004 ) . Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow . Blood vol. 103 , ( 3 ) 868 - 877 .
Bystrom J, Swartz JM, Wynn TA, Domachowske JB, Rosenberg HF ( 2004 ) . Interleukin-5 and gene transcription in mouse bone marrow in vivo . IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY . 9 - 14 .
Nitto T, Mejia RA, Bystrom J, Dyer KD, Wynn TA, Rosenberg HF ( 2003 ) . IL-5 dependent regulation of eosinophil ribonuclease gene expression . BLOOD . vol. 102 , 524A - 524A .
Byström J, Garcia RC, Håkansson L, Karawajczyk M, Moberg L, Soukka J, Venge P ( 2002 ) . Eosinophil cationic protein is stored in, but not produced by, peripheral blood neutrophils . Clin Exp Allergy vol. 32 , ( 7 ) 1082 - 1091 .
Jönsson U-B, Byström J, Stålenheim G, Venge P ( 2002 ) . Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms . Clin Exp Allergy vol. 32 , ( 7 ) 1092 - 1095 .
Byström J, Tenno T, Håkansson L, Amin K, Trulson A, Högbom E, Venge P ( 2001 ) . Monocytes, but not macrophages, produce the eosinophil cationic protein . APMIS vol. 109 , ( 7-8 ) 507 - 516 .
Bystrom J, Garcia RC, Hakansson L, Karawajczyk M, Moberg L, Soukka J, Venge P ( 2000 ) . Eosinophil cationic protein (ECP) is stored in, but not produced by neutrophils . BLOOD vol. 96 , ( 11 ) 27B - 27B .