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Research

Publications: Dr Eleni Maniati

D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al. ( 2022 ) . ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning . Development (Cambridge, England) vol. 149 , ( 13 )
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al. ( 2022 ) . Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer . Cancer Research vol. 82 , ( 12_Supplement ) 693 - 693 .
Gopinathan G, Berlato C, Lakhani A, Szabova L, Pegrum C, Pedrosa AR, Laforets F, Maniati E et al. ( 2022 ) . Immune Mechanisms of Resistance to Cediranib in Ovarian Cancer . Molecular Cancer Therapeutics vol. 21 , ( 6 ) 1030 - 1045 .
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C et al. ( 2021 ) . Tgfbi production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer . Cancer Research vol. 81 , ( 22 ) 5706 - 5719 .
Mian S, Philippe C, Maniati E, Bergot T, Piganeau M, Di Bella D, Morales V, Finch A et al. ( 2021 ) . Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia . Blood vol. 138 , ( Supplement 1 ) 324 - 324 .
Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B et al. ( 2021 ) . Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections . Science Advances vol. 7 , ( 37 )
Gopinathan G, Maniati E, Berlato C, Lakhani A, Pergum C, Laforets F, Szabova L, Balkwill F ( 2021 ) . Abstract 1094: Differential responses and mechanisms of resistance to cediranib in high grade serous ovarian cancer mouse models . Cancer Research . vol. 81 , 1094 - 1094 .
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . Cancer Research . vol. 81 , 2642 - 2642 .
Berlato C, Heath O, Maniati E, Gopinathan G, Kotantaki P, Elorbany S, McDermott J, Pegrum C et al. ( 2021 ) . Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy . Cancer Research . vol. 81 , 2745 - 2745 .
Devlin M-J, Kristeleit RS, McDermott J, Maniati E, Laforêts F, Kotantaki P, Miller R, Balkwill F ( 2021 ) . Abstract 2748: Impact of ARID1A mutation on the tumor microenvironment of advanced clear cell ovarian cancer . Cancer Research . vol. 81 , 2748 - 2748 .
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Nikodemus D, van Agtmael T, Maniati E, Kyoung JW et al. ( 2021 ) . Basement membranes: Not just simple barriers . EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS . vol. 50 , 136 - 136 .
Gopinathan G, Maniati E, Berlato C, Lakhani A, Pergum C, Laforets F, Szabova L, Balkwill F ( 2021 ) . Differential responses and mechanisms of resistance to cediranib in high grade serous ovarian cancer mouse models . CANCER RESEARCH . vol. 81 ,
Devlin M-J, Kristeleit RS, McDermott J, Maniati E, Laforets F, Kotantaki P, Miller R, Balkwill F ( 2021 ) . Impact of ARID1A mutation on the tumor microenvironment of advanced clear cell ovarian cancer . CANCER RESEARCH . vol. 81 ,
Berlato C, Heath O, Maniati E, Gopinathan G, Kotantaki P, Elorbany S, McDermott J, Pegrum C et al. ( 2021 ) . Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy . CANCER RESEARCH . vol. 81 ,
Malacrida B, Delaine-Smith R, Nichols S, Maniati E, Jones RL, Knight MM, Pearce OM, Balkwill FR ( 2021 ) . Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer . CANCER RESEARCH . vol. 81 ,
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al. ( 2021 ) . A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion . iScience vol. 24 , ( 6 )
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . iScience vol. 24 , ( 6 )
Anene CA, Khan F, Bewicke-Copley F, Maniati E, Wang J ( 2021 ) . ACSNI: An unsupervised machine-learning tool for prediction of tissue-specific pathway components using gene expression profiles . Patterns vol. 2 , ( 6 ) Article 100270 , 100270 - 100270 .
Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L et al. ( 2021 ) . Basement membrane stiffness determines metastases formation . Nature Materials vol. 20 , ( 6 ) 892 - 903 .
Heath O, Berlato C, Maniati E, Lakhani A, Pegrum C, Kotantaki P, Elorbany S, Bohm S et al. ( 2021 ) . Chemotherapy induces tumor-associated macrophages that aid adaptive immune responses in ovarian cancer . Cancer Immunology Research vol. 9 , ( 6 ) 665 - 681 .
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Erratum: Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma (NAR Cancer (2021) 3:1 (zcab009) DOI: 10.1093/narcan/zcab009) . NAR Cancer vol. 3 , ( 2 )
Freire-Beneitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, Wang J, Rajeeve V et al. ( 2021 ) . Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma . NAR Cancer vol. 3 , ( 1 )
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O et al. ( 2021 ) . Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer . biorxiv.org
Tse WY, Maniati E, Wang J, Lockley M, Martin S ( 2021 ) . Identification of a novel regulator of FANCD2 mediated DNA Repair . Conference: Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al. ( 2020 ) . Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma . Cancer Research
Hoare JI, Hockings H, Saxena J, Silva VL, Maniati E, Mirza HB, Huang W, Wood GE et al. ( 2020 ) . Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancer .
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance . Cancer Research . vol. 80 , a31 - a31 .
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Tumor stroma in the development of acquired cancer therapy resistance . CANCER RESEARCH . vol. 80 , 48 - 48 .
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al. ( 2020 ) . Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment . SSRN Electronic Journal
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease . Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
Heath OM, Maniati E, Belato C, Gopinathan G, Lecker L, Lakhani A, Pegrum C, McDermott J et al. ( 2019 ) . Abstract 1103: The effects of neo-adjuvant chemotherapy on myeloid cells in high-grade serous ovarian cancer metastases . Cancer Research . vol. 79 , 1103 - 1103 .
Spear S, Candido JB, McDermott JR, Ghirelli C, Maniati E, Beers SA, Balkwill FR, Kocher HM et al. ( 2019 ) . Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells . Frontiers in Immunology vol. 10 , ( MAR )
Pearce OMT, Nichols S, Delaine-Smith R, Jones RR, Maniati E, Rootizalab R, Mackerodt J, Knight MM et al. ( 2018 ) . Investigating drivers of the tumour matrisome, and their role in disease progression . INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY . vol. 99 , A49 - A49 .
Lecker LS, Trevisan C, Delaine-Smith R, Maniati E, Pearce O, Meinert C, Iwanicki M, Drapkin R et al. ( 2018 ) . Abstract A31: Mutant p53 increases integrin-ECM interactions in early HGSOC . Clinical Cancer Research . vol. 24 , a31 - a31 .
Lecker LSM, Trevisan C, Delaine-Smith R, Maniati E, Pearce O, Meinert C, Iwanicki M, Drapkin R et al. ( 2018 ) . Mutant p53 increases integrin-ECM interactions in early HGSOC . CLINICAL CANCER RESEARCH . vol. 24 , 54 - 54 .
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M ( 2017 ) . Abstract 5558: Deconstruction of a human tumor microenvironment . Cancer Research . vol. 77 , 5558 - 5558 .
BALKWILL F, Berlato C, Khan MN, Schioppa T, Thompson R, Maniati E, Montfort A, Jangani M et al. ( 2017 ) . A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer . Journal of Clinical Investigation
Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH et al. ( 2016 ) . A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases . Clinical Cancer Research
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Serrels A, Lund T, Serrels B, Byron A, McPherson RC, Von Kriegsheim A, Gómez-Cuadrado L, Canel M et al. ( 2015 ) . Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity . Cell vol. 163 , ( 1 ) 160 - 173 .
Chard LS, Maniati E, Wang P, Zhang Z, Gao D, Wang J, Cao F, Ahmed J et al. ( 2015 ) . A vaccinia virus armed with interleukin-10 Is a promising therapeutic agent for treatment of murine pancreatic cancer . Clinical Cancer Research vol. 21 , ( 2 ) 405 - 416 .
Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O et al. ( 2014 ) . Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis . Nat Commun vol. 5 ,
Berlato C, Kahn MN, Schioppa T, Thompson R, Maniati E, Canosa M, Kulbe H, Sheldon C et al. ( 2014 ) . Abstract 1076: Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer . Conference: Tumor Biology1076 - 1076 .
Popov N, Maniati E, Marzec J, Okosun J, Scott R, Kranz A, Stewart F, Chelala C et al. ( 2013 ) . Investigating The Role Of MLL2 (Mll4) In B Cell Development . Blood . vol. 122 , 343 - 343 .
Maniati E, Hagemann T ( 2013 ) . IL-17 mediates resistance to anti-VEGF therapy . Nat Med vol. 19 , ( 9 ) 1092 - 1094 .
Chard LS, Maniati E, Wang P, Hughes J, Wang J, Denes B, Fodor I, Hagemann T et al. ( 2013 ) . A Vaccinia Virus Armed with Interleukin-10 That Dampens Host Immunity to the Vctor but Not to Tumor Is a Promising Therapeutic Agent for Pancreatic Cancer . MOLECULAR THERAPY . vol. 21 , S196 - S196 .
Neyen C, Plüddemann A, Mukhopadhyay S, Maniati E, Bossard M, Gordon S, Hagemann T ( 2013 ) . Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer . J Immunol vol. 190 , ( 7 ) 3798 - 3805 .
Cappuccini F, Wirsdoerfer F, Maniati E, Hagemann T, Stuschke M, Jendrossek V ( 2012 ) . Potential Role of Lymphocytes During DNA Damage-induced Pneumopathy . EUROPEAN JOURNAL OF CANCER . vol. 48 , S269 - S269 .
Cappuccini F, Wirsdoerfer F, Maniati E, Hagemann T, Westendorf A, Stuschke M, Jendrossek V ( 2012 ) . Lymphocytes play a role in radiation-induced pneumopathy . STRAHLENTHERAPIE UND ONKOLOGIE . vol. 188 , 126 - 127 .
Emami-Shahri N, Maniati E, Bossard M, Hagemann T ( 2012 ) . Abstract 3209: Metformin suppresses the growth and modulates the metabolic profiles of pancreatic cancer cells under hypoxia in an IKKα-dependent manner . Cancer Research vol. 72 , ( 8_Supplement ) 3209 - 3209 .
Maniati E, Bossard M, Cook N, Candido J, Emami-Shahri N, Nedospasov S, Balkwill F, Tuveson D et al. ( 2011 ) . Cross-talk between IKK2 and Notch promotes pancreatic cancer progression in mice through Hes1 mediated PPAR gamma inhibitio . IMMUNOLOGY . vol. 135 , 169 - 169 .
Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA, Balkwill FR, Tuveson DA et al. ( 2011 ) . Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice . J Clin Invest vol. 121 , ( 12 ) 4685 - 4699 .
Hallam SL, Candido J, Coutinho R, Maniati E, Thompson RG, van Rooijen N, Hagemann T, Gribben JG ( 2011 ) . Manipulating Tumor Associated Macrophages (TAM) in a Mouse Model of B-Cell Non-Hodgkin Lymphoma (NHL) . Blood vol. 118 , ( 21 ) 1657 - 1657 .
Maniati E, Soper R, Hagemann T ( 2010 ) . Up for Mischief? IL-17/Th17 in the tumour microenvironment . Oncogene vol. 29 , ( 42 ) 5653 - 5662 .
Maniati E, Rogers N, Morley B ( 2010 ) . Apoptosis in Autoimmunity . Apoptosis ,
Rogers NJ, Lees MJ, Gabriel L, Maniati E, Rose SJ, Potter PK, Morley BJ ( 2009 ) . A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells . J Immunol vol. 182 , ( 4 ) 1982 - 1990 .
Maniati E, Aw D, Palmer DB, Morley BJ, Rogers NJ ( 2008 ) . Alterations of the thymic environment in murine models of SLE . IMMUNOLOGY . vol. 125 , 113 - 113 .
Gabriel L, Maniati E, Morley BJ, Rogers NJ ( 2008 ) . The role of NKT cells in the immunopathology of systemic lupus erythematosus . IMMUNOLOGY . vol. 125 , 111 - 111 .
Maniati E, Gomes MJ, Gabriel L, Morley BJ, Rogers NJ ( 2008 ) . The role of toll-like receptors in the BXSB model of SLE . IMMUNOLOGY . vol. 125 , 112 - 113 .
Maniati E, Potter P, Rogers NJ, Morley BJ ( 2008 ) . Control of apoptosis in autoimmunity . J Pathol vol. 214 , ( 2 ) 190 - 198 .
Maniati E, Rogers NJ, Morley BJ ( 2007 ) . Lymphoid tissue distribution of DC subtypes in a murine model of SLE . IMMUNOLOGY . vol. 120 , 73 - 73 .