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Research

Publications: Dr Pedro Casado-Izquierdo

Nobre LV, Basanta CC, Pedicona SF, Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F et al. ( 2021 ) . Abstract LBA013: Phosphoproteomics reveals active drug targets on pathways of resistance and predicts response to midostaurin plus chemotherapy in FLT3 mutant-positive acute myeloid leukemia . Molecular Cancer Therapeutics . vol. 20 , lba013 - lba013 .
Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue SI, Scagliotti V et al. ( 2021 ) . Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans . Nature Communications vol. 12 , ( 1 )
Gerdes H, Casado P, Dokal A, Hijazi M, Akhtar N, Osuntola R, Rajeeve V, Fitzgibbon J et al. ( 2021 ) . Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs . Nature Communications vol. 12 , ( 1 )
Veiga Nobre LMV, Pedicona SF, Dokal A, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo P et al. ( 2021 ) . Proteomics and Phospho-Proteomics Reveal Predictive Signatures of Response and Mechanisms of Resistance to Midostaurin Plus Chemotherapy in FLT3 Mutant Positive Acute Myeloid Leukemia . Blood vol. 138 , ( Supplement 1 ) 3462 - 3462 .
Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al. ( 2021 ) . Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes . Cell Death and Disease vol. 12 , ( 11 )
Dokal AD, Arruda A, Smith R, Greenhalgh C, Patella F, Casado-Izquierdo PM, Wrench B, Theaker J et al. ( 2021 ) . Predictive phosphoproteomic signatures for midostaurin plus chemotherapy response in FLT3 mutant positive acute myeloid leukaemia . Journal of Clinical Oncology vol. 39 , ( 15_suppl ) 7019 - 7019 .
Martín-Guerrero SM, Alonso P, Iglesias A, Cimadevila M, Brea J, Loza MI, Casado P, Martín-Oliva D et al. ( 2021 ) . His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics . Biochem Pharmacol vol. 185 ,
Martín-Guerrero SM, Casado P, Hijazi M, Rajeeve V, Plaza-Díaz J, Abadía-Molina F, Navascués J, Cuadros MA et al. ( 2020 ) . PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability . Biochem J vol. 477 , ( 23 ) 4491 - 4513 .
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .
Fernández-Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, Oller L, Macías-Muñoz L et al. ( 2020 ) . Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma . Hepatology vol. 72 , ( 4 ) 1267 - 1282 .
Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C et al. ( 2020 ) . A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity . British Journal of Cancer vol. 123 , ( 4 ) 542 - 555 .
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) 1290 - 1290 .
Carvajal S, Perramón M, Casals G, Oró D, Ribera J, Morales-Ruiz M, Casals E, Casado P et al. ( 2019 ) . Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes . Int J Mol Sci vol. 20 , ( 23 )
Grey W, Casado-Izquierdo P, Cutillas P, Bonnet D ( 2019 ) . Combination Therapy Targeting CKS1-Dependent Protein Degradation Reduces AML Burden Whilst Protecting Normal Haematopoietic Stem Cellsfrom Cytarabine Toxicity . Blood vol. 134 , ( Supplement_1 ) 2535 - 2535 .
Martín-Guerrero SM, Casado P, Muñoz-Gámez JA, Carrasco M-C, Navascués J, Cuadros MA, López-Giménez JF, Cutillas PR et al. ( 2019 ) . Poly(ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells . Exp Eye Res vol. 188 ,
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V et al. ( 2018 ) . Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility . Nat Commun vol. 9 , ( 1 )
Álvarez-Teijeiro S, García-Inclán C, Villaronga MÁ, Casado P, Hermida-Prado F, Granda-Díaz R, Rodrigo JP, Calvo F et al. ( 2018 ) . Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets . Cancers (Basel) vol. 10 , ( 9 )
Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S et al. ( 2018 ) . Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells . Leukemia vol. 32 , ( 8 ) 1818 - 1822 .
Corominas MP, Restoy SC, Casals G, Oró D, Ribera J, Casals E, Casado-Izquierdo P, Varo GF et al. ( 2018 ) . THU-028 Cerium oxide nanoparticles protect against oxidant mediated injury and recover kinase activity of multiple pathways in human-derived hepatocellular carcinoma cells . Journal of Hepatology . vol. 68 ,
Warrick N, Miraki-Moud F, Aicher A, McNaughton LA, Casado-Izquierdo P, Nagano A, Carroll R, Bonnet D et al. ( 2017 ) . Adipocyte Induced Antagonism of ALL Growth Highlights a Novel Inhibitory Niche and Potential Therapeutic Opportunity . BLOOD . vol. 130 ,
Wilkes EH, Casado P, Rajeeve V, Cutillas PR ( 2017 ) . Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability . Mol Cell Proteomics vol. 16 , ( 9 ) 1694 - 1704 .
Casado-Izquierdo P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Sameena I et al. ( 2017 ) . PHOSPHOPROTEOMICS AND MASS CYTOMETRY SIGNATURES OF PRIMARY AML CELL DIFFERENTIATION ARE ASSOCIATED WITH SENSITIVITY TO KINASE INHIBITORS . HAEMATOLOGICA . vol. 102 , 203 - 203 .
Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV et al. ( 2016 ) . Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition . Oncogene
Casado P, Hijazi M, Britton D, Cutillas PR ( 2016 ) . Impact of phosphoproteomics in the translation of kinase targeted therapies . Proteomics
Bouchekioua-Bouzaghou K, Lenihan C, Shia A, Wilkes E, Casado-Izquierdo P, Cutillas P, Schmid P ( 2016 ) . Abstract 2819: Characterization of the mechanisms of early and later stages of resistance to the selective CDK4/6 inhibitor palbociclib . Cancer Research . vol. 76 , 2819 - 2819 .
Lenihan C, Bouchekioua-Bouzaghou K, Shia A, Wilkes E, Casado-Izquierdo1 P, Cutillas P, Schmid P ( 2016 ) . Abstract P3-06-02: Characterization of resistance to the selective CDK4/6 inhibitor palbociclib in ER positive breast cancer . Cancer Research . vol. 76 ,
Terfve CDA, Wilkes EH, Casado P, Cutillas PR, Saez-Rodriguez J ( 2015 ) . Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data . Nat Commun vol. 6 ,
Carretero L, Llavona P, López-Hernández A, Casado P, Cutillas PR, de la Peña P, Barros F, Domínguez P ( 2015 ) . ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells . Cell Signal vol. 27 , ( 9 ) 1720 - 1730 .
Wilkes EH, Casado P, Cutillas PR ( 2014 ) . Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies . Biochem Soc Trans vol. 42 , ( 4 ) 791 - 797 .
Casado P, Bilanges B, Rajeeve V, Vanhaesebroeck B, Cutillas PR ( 2014 ) . Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells . Mol Cell Proteomics vol. 13 , ( 3 ) 836 - 848 .
Cabal-Hierro L, Artime N, Iglesias J, Prado MA, Ugarte-Gil L, Casado P, Fernández-García B, Darnay BG et al. ( 2014 ) . A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 . Oncotarget vol. 5 , ( 1 ) 224 - 236 .
Casado P, Alcolea MP, Iorio F, Rodríguez-Prados J-C, Vanhaesebroeck B, Saez-Rodriguez J, Joel S, Cutillas PR ( 2013 ) . Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors . Genome Biol vol. 14 , ( 4 )
Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR ( 2012 ) . Global profiling of protein kinase activities in cancer cells by mass spectrometry . J Proteomics vol. 77 , 492 - 503 .
Alcolea MP, Casado P, Rodríguez-Prados J-C, Vanhaesebroeck B, Cutillas PR ( 2012 ) . Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance . Mol Cell Proteomics vol. 11 , ( 8 ) 453 - 466 .
Montoya A, Beltran L, Casado P, Rodríguez-Prados J-C, Cutillas PR ( 2011 ) . Characterization of a TiO₂ enrichment method for label-free quantitative phosphoproteomics . Methods vol. 54 , ( 4 ) 370 - 378 .
Casado P, Cutillas PR ( 2011 ) . A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments . Mol Cell Proteomics vol. 10 , ( 1 )
Fernandez-Garcia B, Casado P, Prado MA, Ugarte-Gil LJ, Artime N, Cabal-Hierro L, Calvo E, López JA et al. ( 2010 ) . Proteomic analysis of annexin A2 phosphorylation induced by microtubule interfering agents and kinesin spindle protein inhibitors . J Proteome Res vol. 9 , ( 9 ) 4649 - 4660 .
Casado P, Prado MA, Zuazua-Villar P, Del Valle E, Artime N, Cabal-Hierro L, Rupérez P, Burlingame AL et al. ( 2009 ) . Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest . J Proteomics vol. 71 , ( 6 ) 592 - 600 .
Prado MA, Casado P, Zuazua-Villar P, del Valle E, Artime N, Cabal-Hierro L, Martínez-Campa CM, Lazo PS et al. ( 2007 ) . Phosphorylation of human eukaryotic elongation factor 1Bgamma is regulated by paclitaxel . Proteomics vol. 7 , ( 18 ) 3299 - 3304 .
Casado P, Zuazua-Villar P, Prado MA, Valle ED, Iglesias JM, Martínez-Campa C, Lazo PS, Ramos S ( 2007 ) . Characterization of HSP27 phosphorylation induced by microtubule interfering agents: implication of p38 signalling pathway . Arch Biochem Biophys vol. 461 , ( 1 ) 123 - 129 .
Casado P, Zuazua-Villar P, del Valle E, Martínez-Campa C, Lazo PS, Ramos S ( 2007 ) . Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells . Cancer Lett vol. 247 , ( 2 ) 273 - 282 .
Martínez-Campa C, Casado P, Rodríguez R, Zuazua P, García-Pedrero JM, Lazo PS, Ramos S ( 2006 ) . Effect of vinca alkaloids on ERalpha levels and estradiol-induced responses in MCF-7 cells . Breast Cancer Res Treat vol. 98 , ( 1 ) 81 - 89 .