Publications: Prof Dave Curtis

Curtis D ( 2024 ) . Assessment of ability of AlphaMissense to identify variants affecting susceptibility to common disease . European Journal of Human Genetics vol. 32 , ( 11 ) 1419 - 1427 .

Heinzer L, Curtis D ( 2024 ) . What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia? . Journal of Translational Genetics and Genomics vol. 8 , ( 1 ) 1 - 12 .

Curtis D ( 2023 ) . Mendel did not study common, naturally occurring phenotypes . Journal of Genetics vol. 102 , ( 2 )

Curtis D ( 2023 ) . Social scientists would do well to steer clear of polygenic scores . Behavioral and Brain Sciences vol. 46 ,

Maury EA, Sherman MA, Genovese G, Gilgenast TG, Kamath T, Burris SJ, Rajarajan P, Flaherty E et al. ( 2023 ) . Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions . Cell Genomics vol. 3 , ( 8 )

Curtis D, Amos W ( 2023 ) . The human genome harbours widespread exclusive yin yang haplotypes . European Journal of Human Genetics vol. 32 , ( 6 ) 691 - 696 .

Curtis D ( 2023 ) . The PREPARE study: benefits of pharmacogenetic testing are unclear . The Lancet vol. 401 , ( 10391 ) 1850 - 1851 .

Hsu Y-HH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W et al. ( 2023 ) . Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia . iScience vol. 26 , ( 5 )

Curtis D ( 2023 ) . Opinion: Increased calorie gain from lactose digestion could contribute to selection for lactase persistence . PLOS Genetics vol. 19 , ( 2 )

Curtis D ( 2022 ) . RE: Extending the vulnerability–stress model of mental disorders: three-dimensional NPSR1 × environment × coping interaction study in anxiety . The British Journal of Psychiatry vol. 222 , ( 1 ) 44 - 45 .

Curtis D ( 2022 ) . Clinical features of UK Biobank subjects carrying loss of function variants in genes implicated in schizophrenia pathogenesis . European Psychiatry vol. 65 , ( Suppl 1 ) s108 - s108 .

Markel KA, Curtis D ( 2022 ) . Study of variants in genes implicated in rare familial migraine syndromes and their association with migraine in 200,000 exome‐sequenced UK Biobank participants . Annals of Human Genetics vol. 86 , ( 6 ) 353 - 360 .

Lencz T, Sabatello M, Docherty A, Peterson RE, Soda T, Austin J, Bierut L, Crepaz-Keay D et al. ( 2022 ) . Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits . The Lancet Psychiatry vol. 9 , ( 10 ) 838 - 844 .

Curtis D ( 2022 ) . Clinical features of UK Biobank subjects carrying protein-truncating variants in genes implicated in schizophrenia pathogenesis . Psychiatric Genetics vol. 32 , ( 4 ) 156 - 161 .

Curtis D ( 2022 ) . Comment on “Evaluation of a Gene–Environment Interaction of PON1 and Low-Level Nerve Agent Exposure with Gulf War Illness: A Prevalence Case–Control Study Drawn from the U.S. Military Health Survey’s National Population Sample” . Environmental Health Perspectives vol. 130 , ( 6 )

Curtis D ( 2022 ) . Identification of specific genes involved in schizophrenia aetiology – what difference does it make? – CORRIGENDUM . The British Journal of Psychiatry vol. 221 , ( 2 ) 495 - 495 .

Palmer DS, Howrigan DP, Chapman SB, Adolfsson R, Bass N, Blackwood D, Boks MPM, Chen C-Y et al. ( 2022 ) . Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia . Nature Genetics vol. 54 , ( 5 ) 541 - 547 .

Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen C-Y et al. ( 2022 ) . Mapping genomic loci implicates genes and synaptic biology in schizophrenia . Nature vol. 604 , ( 7906 ) 502 - 508 .

Singh T, Poterba T, Curtis D, Akil H, Al Eissa M, Barchas JD, Bass N, Bigdeli TB et al. ( 2022 ) . Rare coding variants in ten genes confer substantial risk for schizophrenia . Nature vol. 604 , ( 7906 ) 509 - 516 .

Curtis D ( 2022 ) . Identification of specific genes involved in schizophrenia aetiology – what difference does it make? . The British Journal of Psychiatry vol. 221 , ( 2 ) 437 - 439 .

Curtis D ( 2022 ) . Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on BMI . International Journal of Obesity vol. 46 , ( 4 ) 782 - 792 .

Biesecker LG, Green ED, Manolio T, Solomon BD, Curtis D ( 2021 ) . Should all babies have their genome sequenced at birth? . The BMJ vol. 375 ,

Curtis D ( 2021 ) . Exploration of weighting schemes based on allele frequency and annotation for weighted burden association analysis of complex phenotypes . Gene vol. 809 ,

Curtis D ( 2021 ) . Analysis of rare coding variants in 200,000 exome‐sequenced subjects reveals novel genetic risk factors for type 2 diabetes . Diabetes/Metabolism Research and Reviews vol. 38 , ( 1 )

Curtis D ( 2021 ) . Analysis of 200,000 Exome-Sequenced UK Biobank Subjects Implicates Genes Involved in Increased and Decreased Risk of Hypertension . Pulse vol. 9 , ( 1-2 ) 17 - 29 .

Curtis D ( 2021 ) . Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences . Psychiatric Genetics vol. 31 , ( 4 ) 140 - 142 .

Curtis D ( 2021 ) . Analysis of 200 000 exome-sequenced UK Biobank subjects fails to identify genes influencing probability of developing a mood disorder resulting in psychiatric referral . Psychiatric Genetics vol. 31 , ( 5 ) 194 - 198 .

Mullins N, Forstner AJ, O’Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB et al. ( 2021 ) . Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology . Nature Genetics vol. 53 , ( 6 ) 817 - 829 .

Curtis D, Alzheimer's Disease Neuroimaging Initiative ( 2021 ) . Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles . Journal of Neurogenetics1 - 8 .

Curtis D ( 2021 ) . Analysis of 200 000 exome-sequenced UK Biobank subjects illustrates the contribution of rare genetic variants to hyperlipidaemia . Journal of Medical Genetics vol. 59 , ( 6 ) 597 - 604 .

Curtis D ( 2021 ) . Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants . Alcohol and Alcoholism vol. 57 , ( 4 ) 421 - 428 .

Curtis D ( 2021 ) . Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects . Human Heredity vol. 85 , ( 2 ) 66 - 68 .

Curtis D ( 2021 ) . Corrigendum to “Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia ” [131/1–2 (2020) 277–283] . Molecular Genetics and Metabolism vol. 132 , ( 3 )

Hilton E, Thompson P, Wright C, Curtis D ( 2021 ) . The reality of sex . Irish Journal of Medical Science

Curtis D ( 2021 ) . Concerns about medical abuses against Uighurs in China . The Lancet vol. 397 , ( 10270 ) 193 - 194 .

Curtis D ( 2021 ) . Multiple Linear Regression Allows Weighted Burden Analysis of Rare Coding Variants in an Ethnically Heterogeneous Population . Human Heredity vol. 85 , ( 1 ) 1 - 10 .

Curtis D ( 2021 ) . Effects of Rare, Functional Variants on Risk of Common Phenotypes in 200,000 Exome-sequenced UK Biobank Participants . GENETIC EPIDEMIOLOGY . vol. 45 , 750 - 751 .

Curtis D ( 2020 ) . Analysis of 50,000 exome-sequenced UK Biobank subjects fails to identify genes influencing probability of developing a mood disorder resulting in psychiatric referral . Journal of Affective Disorders vol. 281 , 216 - 219 .

Curtis D, Bandyopadhyay S ( 2020 ) . Mini-review: Role of the PI3K/Akt pathway and tyrosine phosphatases in Alzheimer's disease susceptibility . Annals of Human Genetics

Curtis D ( 2020 ) . Do damaging variants of SLC6A9, the gene for the glycine transporter 1 (GlyT-1), protect against schizophrenia? . Psychiatric Genetics150 - 152 .

Curtis D ( 2020 ) . Analysis of exome-sequenced UK Biobank subjects implicates genes affecting risk of hyperlipidaemia . Molecular Genetics and Metabolism

Curtis D ( 2020 ) . Study of Transgender Patients: Conclusions Are Not Supported by Findings . American Journal of Psychiatry vol. 177 , ( 8 ) 766 - 766 .

Balogha E, Chandlerc JC, Vargaa M, Tahounc M, Menyhárdf DK, Schaya G, Goncalvesi T, Hamard R et al. ( 2020 ) . Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis . Proceedings of the National Academy of Sciences of the United States of America vol. 117 , ( 26 ) 15137 - 15147 .

Arranz MJ, Bakker S, Bender S, Bramon E, Collier DA, Crespo-Facorro B, Hall J, Iyegbe C et al. ( 2020 ) . Complement genes contribute sex-biased vulnerability in diverse disorders . Nature vol. 582 , ( 7813 ) 577 - 581 .

Curtis D, Balloux F ( 2020 ) . Editorial: Topical ethical issues in the publication of human genetics research . Annals of Human Genetics vol. 84 , ( 4 ) 313 - 314 .

Curtis D, Bakaya K, Sharma L, Bandyopadhyay S ( 2020 ) . Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways . Annals of Human Genetics

Alexander M, CURTIS D ( 2020 ) . LD scores are associated with differences in allele frequencies between populations but LD score regression can still distinguish confounding from polygenicity . Annals of Human Genetics

Curtis D ( 2020 ) . Weighted burden analysis of exome-sequenced late onset alzheimer's cases and controls provides further evidence for involvement of psen1 and demonstrates role for pi3k/akt/gsk-3β signalling pathway . EUROPEAN PSYCHIATRY . vol. 63 , S151 - S152 .

Consortium C-DGOTPG, Lee PH, Anttila V, Won H, Feng Y-CA, Rosenthal J, Zhu Z, Tucker-Drob EM et al. ( 2019 ) . Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders . Cell vol. 179 , ( 7 ) 1469 - 1482.e11 .

Alliey-Rodriguez N, Grey TA, Shafee R, Asif H, Lutz O, Bolo NR, Padmanabhan J, Tandon N et al. ( 2019 ) . NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis . Translational Psychiatry vol. 9 , ( 1 )

Curtis D ( 2019 ) . A possible role for sarcosine in the management of schizophrenia . British Journal of Psychiatry vol. 215 , ( 6 ) 697 - 698 .

Hess JL, Tylee DS, Mattheisen M, Børglum AD, Als TD, Grove J, Werge T, Mortensen PB et al. ( 2019 ) . A polygenic resilience score moderates the genetic risk for schizophrenia . Molecular Psychiatry vol. 26 , ( 3 ) 800 - 815 .

Balakrishna T, Curtis D ( 2019 ) . Assessment of Potential Clinical Role for Exome Sequencing in Schizophrenia . Schizophr Bull

Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y et al. ( 2019 ) . Genome-wide association study identifies 30 loci associated with bipolar disorder . Nature Genetics vol. 51 , ( 5 ) 793 - 803 .

Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E et al. ( 2019 ) . Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia . American Journal of Human Genetics vol. 104 , ( 5 ) 948 - 956 .

CURTIS D ( 2019 ) . Clinical relevance of genome‐wide polygenic score may be less than claimed . Annals of Human Genetics

Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD et al. ( 2019 ) . Gene expression imputation across multiple brain regions provides insights into schizophrenia risk . Nature Genetics vol. 51 , ( 4 ) 659 - 674 .

Curtis D, Adlington K, Bhui KS ( 2019 ) . Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service . The British Journal of Psychiatry vol. 214 , ( 5 ) 248 - 250 .

Drange OK, Smeland OB, Shadrin AA, Finseth PI, Witoelar A, Frei O, Group PGCBDW, Wang Y et al. ( 2019 ) . Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes . Frontiers in Neuroscience vol. 13 ,

Al Eissa MM, Sharp SL, O'Brien NL, Fiorentino A, Bass NJ, CURTIS D, McQuillin A ( 2019 ) . Genetic Association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia . Amercian Journal of Medical Genetics Part B Neuropsychiatric Genetics

Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ et al. ( 2019 ) . Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 180 , ( 3 ) 223 - 231 .

CURTIS D, Tsavou A ( 2019 ) . In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia . Psychiatric Genetics

Aleissa M, Sharp S, Fiorentino A, O'Brien N, Bass N, Curtis D, McQuillin A ( 2019 ) . M23 GENETIC ASSOCIATION AND FUNCTIONAL CHARACTERIZATION OF A VARIANT IN THE MCPH1 GENE IN BIPOLAR DISORDER AND SCHIZOPHRENIA . European Neuropsychopharmacology . vol. 29 , s966 - s967 .

Curtis D ( 2019 ) . SU26A WEIGHTED BURDEN TEST USING LOGISTIC REGRESSION FOR INTEGRATED ANALYSIS OF SEQUENCE VARIANTS, COPY NUMBER VARIANTS AND POLYGENIC RISK SCORE . European Neuropsychopharmacology . vol. 29 , s1281 - s1282 .

Curtis D ( 2018 ) . Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia . Psychiatr Genet vol. 28 , ( 5 ) 85 - 89 .

Curtis D ( 2018 ) . A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score . European Journal of Human Genetics vol. 27 , ( 1 ) 114 - 124 .

Ni G, Gratten J, Wray NR, Lee SH, Ripke S, Neale BM, Corvin A, Walters JTR et al. ( 2018 ) . Age at first birth in women is genetically associated with increased risk of schizophrenia . Scientific Reports vol. 8 , ( 1 )

LeBlanc M, Zuber V, Thompson WK, Andreassen OA, Frigessi A, Andreassen BK, Ripke S, Neale BM et al. ( 2018 ) . A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework . BMC Genomics vol. 19 , ( 1 )

Consortium TB, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V et al. ( 2018 ) . Analysis of shared heritability in common disorders of the brain . Science vol. 360 , ( 6395 )

COELEWIJ L, CURTIS D ( 2018 ) . Mini‐review: Update on the genetics of schizophrenia . Annals of Human Genetics

Ruderfer DM, Ripke S, McQuillin A, Boocock J, Stahl EA, Pavlides JMW, Mullins N, Charney AW et al. ( 2018 ) . Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes . Cell

Gupta S, Akyuz E, Baldwin T, CURTIS D ( 2018 ) . Community treatment orders in England: Review of usage from national data . BJPsych Bulletin

Curtis D ( 2018 ) . Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets . Psychiatr Genet

Curtis D, Coelewij L, Liu S-H, Humphrey J, Mott R ( 2018 ) . Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology . Behavior Genetics vol. 48 , ( 3 ) 198 - 208 .

O'Brien NL, Fiorentino A, Curtis D, Rayner C, Petrosellini C, Al Eissa M, Bass NJ, McQuillin A et al. ( 2018 ) . Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder . Schizophrenia Research vol. 199 , 181 - 188 .

Al Eissa MM, Fiorentino A, Sharp SI, O'Brien NL, Wolfe K, Giaroli G, Curtis D, Bass NJ et al. ( 2018 ) . Exome sequence analysis and follow up genotyping implicates rare ULK1 variants to be involved in susceptibility to schizophrenia . Annals of Human Genetics

Bhandari S, Curtis D ( 2018 ) . Semantic priming in schizophrenia . The British Journal of Psychiatry vol. 173 , ( 2 ) 184 - 184 .

Rees E, Walters JTR, Georgieva L, Isles AR, Chambert KD, Richards AL, Mahoney-Davies G, Legge SE et al. ( 2018 ) . Analysis of copy number variations at 15 schizophrenia-associated loci . The British Journal of Psychiatry vol. 204 , ( 2 ) 108 - 114 .

Crossan I, Curtis D, Ong Y-L ( 2018 ) . Audit of psychiatric discharge summaries: completing the cycle . BJPsych Bulletin vol. 28 , ( 9 ) 329 - 331 .

Curtis D, Robertson MM, Gurling HMD ( 2018 ) . Autosomal Dominant Gene Transmission in a Large Kindred with Gilles de la Tourette Syndrome . The British Journal of Psychiatry vol. 160 , ( 6 ) 845 - 849 .

Collinge J, Curtis D ( 2018 ) . Decreased Hippocampal Expression of a Glutamate Receptor Gene in Schizophrenia . The British Journal of Psychiatry vol. 159 , ( 6 ) 857 - 859 .

Kalsi G, Curtis D, Brynjolfsson J, Butler R, Sharma T, Murphy P, Read T, Petursson H et al. ( 2018 ) . Investigation by Linkage Analysis of the XY Pseudoautosomal Region in the Genetic Susceptibility to Schizophrenia . The British Journal of Psychiatry vol. 167 , ( 3 ) 390 - 393 .

Vincent A, Curtis D ( 2018 ) . Link between outcome and service quality is not clear . The British Journal of Psychiatry vol. 202 , ( 4 ) 309 - 309 .

Curtis D, Kerr M ( 2018 ) . NICE recommendations for valproate treatment are unhelpful . The British Journal of Psychiatry vol. 186 , ( 5 ) 447 - 447 .

Holmes D, Brynjolfsson J, Brett P, Curtis D, Petursson H, Sherrington R, Gurling H ( 2018 ) . No Evidence for a Susceptibility Locus Predisposing to Manic Depression in the Region of the Dopamine (D2) Receptor Gene . The British Journal of Psychiatry vol. 158 , ( 5 ) 635 - 641 .

Curtis D ( 2018 ) . OCTET does not demonstrate a lack of effectiveness for community treatment orders . BJPsych Bulletin vol. 38 , ( 1 ) 36 - 39 .

Woodgate M, Curtis D ( 2018 ) . Prenatal exposure to the 1957 influenza epidemic . The British Journal of Psychiatry vol. 168 , ( 6 ) 791 - 791 .

Curtis D, Kalsi G, Gurling HMD ( 2018 ) . Pseudoautosomal linkage in schizophrenia . The British Journal of Psychiatry vol. 165 , ( 1 ) 117 - 118 .

Curtis D ( 2018 ) . Schizophrenia following prenatal exposure to influenza epidemics between 1939 and 1960 . The British Journal of Psychiatry vol. 161 , ( 5 ) 712 - 713 .

Curtis D ( 2018 ) . Schizophrenia genetics moves into the light . The British Journal of Psychiatry vol. 209 , ( 2 ) 93 - 94 .

Curtis D, Gurling H ( 2018 ) . Unsound Methodology in Investigating a Pseudoautosomal Locus in Schizophrenia . The British Journal of Psychiatry vol. 156 , ( 3 ) 415 - 416 .

Aleissa M, Sharp SI, Brien NLO, Fiorentino A, Bass NJ, Curtis D, McQuillin A ( 2018 ) . Genetic association and functional characterization of a variant in the <i>MCPH1</i> gene in bipolar disorder and schizophrenia . EUROPEAN JOURNAL OF HUMAN GENETICS . vol. 26 , 416 - 416 .

Curtis D, Emmett W ( 2017 ) . Association study of schizophrenia with variants in miR-137 binding sites . Schizophrenia Research vol. 197 , 346 - 348 .

Curtis D ( 2017 ) . Construction of an Exome‐Wide Risk Score for Schizophrenia Based on a Weighted Burden Test . Annals of Human Genetics vol. 82 , ( 1 ) 11 - 22 .

Curtis D, Derks EM ( 2017 ) . Letter to the Editor: Schizophrenia does not represent the extreme of a normally distributed trait . Psychol Med1 - 2 .

Curtis D ( 2017 ) . Association between smoking and psychosis may be mediated by maternal smoking during pregnancy . Psychol Med1 - 1 .

Leonenko G, Richards AL, Walters JT, Pocklington A, Chambert K, Al Eissa MM, Sharp SI, O'Brien NL et al. ( 2017 ) . Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 174 , ( 7 ) 724 - 731 .

Hendricks AE, Bochukova EG, Marenne G, Keogh JM, Atanassova N, Bounds R, Wheeler E, Mistry V et al. ( 2017 ) . Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity . Sci Rep vol. 7 , ( 1 ) 4394 - 4394 .

Singh T, Walters JTR, Johnstone M, Curtis D, Suvisaari J, Torniainen M, Rees E, Iyegbe C et al. ( 2017 ) . The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability . Nat Genet

Witt SH, Streit F, Jungkunz M, Frank J, Awasthi S, Reinbold CS, Treutlein J, Degenhardt F et al. ( 2017 ) . Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia . Transl Psychiatry vol. 7 , ( 6 ) e1155 - e1155 .

Curtis D, Emmett W ( 2017 ) . Association study of schizophrenia with variants in miR-137 binding sites .

Curtis D . Construction of an exome-wide risk score for schizophrenia based on a weighted burden test .

McLaughlin RL, Schijven D, Van Rheenen W, Van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A et al. ( 2017 ) . Genetic correlation between amyotrophic lateral sclerosis and schizophrenia . Nature Communications vol. 8 ,

Fiorentino A, O'Brien NL, Sharp SI, Curtis D, Bass NJ, McQuillin A ( 2016 ) . Genetic variation in the miR-708 gene and its binding targets in bipolar disorder . Bipolar Disord vol. 18 , ( 8 ) 650 - 656 .

Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, Wu W, Greer DS, Antaki D, Shetty A et al. ( 2016 ) . Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects . Nature Genetics vol. 49 , ( 1 ) 27 - 35 .

Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Breen G, Borglum A, Cichon S, Degenhardt F et al. ( 2016 ) . No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study . PLoS Genet vol. 12 , ( 10 ) e1006343 - e1006343 .

Curtis D ( 2016 ) . Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia . Psychiatr Genet vol. 26 , ( 5 ) 223 - 227 .

Al Eissa M, Fiorentino A, Sharp S, O'Brien NL, Giaroli G, Wolf K, Bass NJ, McQuillin A et al. ( 2016 ) . Potential involvement of a CLSTN3 variant in susceptibility to schizophrenia . EUROPEAN NEUROPSYCHOPHARMACOLOGY . Conference: EUROPEAN NEUROPSYCHOPHARMACOLOGY vol. 26 , S575 - S576 .

Curtis JA, O'Brien NL, Curtis D, Fiorentino A, McQuillin A ( 2016 ) . Association study of rare nonsynonymous variants of FTO in bipolar disorder . Psychiatr Genet vol. 26 , ( 3 ) 140 - 141 .

Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, Suvisaari J, Chheda H et al. ( 2016 ) . Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders . Nature Neuroscience vol. 19 , ( 4 ) 571 - 577 .

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJE, Arias-Vasquez A, Smoller JW et al. ( 2016 ) . Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept . Nature Neuroscience vol. 19 , ( 3 ) 420 - 431 .

Curtis D, Consortium TU ( 2015 ) . Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia . Annals of Human Genetics vol. 80 , ( 1 ) 38 - 49 .

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh P-R et al. ( 2015 ) . Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores . American Journal of Human Genetics vol. 97 , ( 4 ) 576 - 592 .

Huang J, Howie B, McCarthy S, Memari Y, Walter K, Min JL, Danecek P, Malerba G et al. ( 2015 ) . Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel . Nature Communications vol. 6 , ( 1 )

Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JRB, Xu C et al. ( 2015 ) . The UK10K project identifies rare variants in health and disease . Nature vol. 526 , ( 7571 ) 82 - 90 .

Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T et al. ( 2015 ) . New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis . International Journal of Epidemiology vol. 44 , ( 5 ) 1706 - 1721 .

Curtis D ( 2015 ) . Rare missense variants within a single gene form yin yang haplotypes . European Journal of Human Genetics vol. 24 , ( 1 ) 139 - 141 .

Curtis D ( 2015 ) . Investigation of Recessive Effects in Schizophrenia Using Next‐Generation Exome Sequence Data . Annals of Human Genetics vol. 79 , ( 5 ) 313 - 319 .

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA et al. ( 2015 ) . Whole-genome sequence-based analysis of thyroid function . Nature Communications vol. 6 , ( 1 )

Grigoroiu-Serbanescu M, Curtis D, Noethen MM, Cichon S, McQuillin A ( 2015 ) . Genome-wide Associated Schizophrenia Snps Do Not Predict Age-of-onset in Bipolar I Disorder . European Psychiatry . vol. 30 ,

Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Daly MJ, Price AL et al. ( 2015 ) . LD Score regression distinguishes confounding from polygenicity in genome-wide association studies . Nature Genetics vol. 47 , ( 3 ) 291 - 295 .

O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM et al. ( 2015 ) . Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways . NATURE NEUROSCIENCE vol. 18 , ( 2 ) 199 - 209 .

Maier R, Moser G, Chen G-B, Ripke S, Consortium C-DWGOTPG, Absher D, Agartz I, Akil H et al. ( 2015 ) . Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder . American Journal of Human Genetics vol. 96 , ( 2 ) 283 - 294 .

Nurnberger J, Curtis D, Murray R, Blackwood D, Jarram A, Mors O ( 2014 ) . In memoriam . Psychiatric Genetics vol. 24 , ( 6 ) 285 - 290 .

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S et al. ( 2014 ) . Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases . American Journal of Human Genetics vol. 95 , ( 5 ) 535 - 552 .

O’Brien NL, Way MJ, Kandaswamy R, Fiorentino A, Sharp SI, Quadri G, Alex J, Anjorin A et al. ( 2014 ) . The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder . Psychiatric Genetics vol. 24 , ( 6 ) 277 - 278 .

Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G, Shin S-Y, Chen L, Futema M et al. ( 2014 ) . A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans . Nature Communications vol. 5 , ( 1 )

Sharp SI, McQuillin A, Marks M, Hunt SP, Stanford SC, Lydall GJ, Morgan MY, Asherson P et al. ( 2014 ) . Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome . American Journal of Medical Genetics Part B Neuropsychiatric Genetics vol. 165 , ( 4 ) 373 - 380 .

Quadri G, McQuillin A, Guerrini I, Thomson AD, Cherian R, Saini J, Ruparelia K, Lydall GJ et al. ( 2014 ) . Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3 . Psychiatric Genetics vol. 24 , ( 3 ) 122 - 123 .

Way M, McQuillin A, Saini J, Ruparelia K, Lydall GJ, Guerrini I, Ball D, Smith I et al. ( 2014 ) . Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population . Addiction Biology vol. 20 , ( 3 ) 594 - 604 .

Kandaswamy R, McQuillin A, Curtis D, Gurling H ( 2014 ) . Allelic Association, DNA Resequencing and Copy Number Variation at the Metabotropic Glutamate Receptor <i>GRM7</i> Gene Locus in Bipolar Disorder . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS vol. 165 , ( 4 ) 365 - 372 .

Fiorentino A, O'Brien NL, Locke DP, McQuillin A, Jarram A, Anjorin A, Kandaswamy R, Curtis D et al. ( 2014 ) . Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data . BIPOLAR DISORDERS vol. 16 , ( 6 ) 583 - 591 .

Ripke S, Neale BM, Corvin A, Walters JTR, Farh KH, Holmans PA, Lee P, Bulik-Sullivan B et al. ( 2014 ) . Biological insights from 108 schizophrenia-associated genetic loci . Nature vol. 511 , ( 7510 ) 421 - 427 .

Curtis D ( 2013 ) . Consider factors that are important to patients when quantifying harms . The BMJ vol. 347 , ( nov06 2 )

Curtis D ( 2013 ) . High prevalence and low fecundity of mental disorders may reflect recessive effects . JAMA Psychiatry vol. 70 , ( 10 )

Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ et al. ( 2013 ) . Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs . Nat Genet vol. 45 , ( 9 ) 984 - 994 .

Curtis D ( 2013 ) . Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing . Psychiatr Genet vol. 23 , ( 1 ) 1 - 10 .

Curtis D ( 2013 ) . Approaches to the detection of recessive effects using next generation sequencing data from outbred populations . Adv Appl Bioinform Chem vol. 6 , 29 - 35 .

Kandaswamy R, McQuillin A, Sharp SI, Fiorentino A, Anjorin A, Blizard RA, Curtis D, Gurling HMD ( 2013 ) . Genetic Association, Mutation Screening, and Functional Analysis of a Kozak Sequence Variant in the Metabotropic Glutamate Receptor 3 Gene in Bipolar Disorder . JAMA PSYCHIATRY vol. 70 , ( 6 ) 591 - 598 .

Curtis S, Curtis D ( 2013 ) . Report fails to acknowledge problems with at-home HIV test . The Lancet vol. 381 , ( 9862 ) 203 - 204 .

( 2012 ) . Corrigendum . Annals of Human Genetics vol. 76 , ( 2 ) 192 - 192 .

Curtis D ( 2012 ) . A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway . Adv Appl Bioinform Chem vol. 5 , 1 - 9 .

Kandaswamy R, McQuillin A, Curtis D, Gurling H ( 2012 ) . Tests of linkage and allelic association between markers in the 1p36 PRKCZ (Protein Kinase C Zeta) gene region and bipolar affective disorder . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS vol. 159B , ( 2 ) 201 - 209 .

Curtis D ( 2012 ) . Thrombolysis in acute ischaemic stroke . LANCET vol. 380 , ( 9847 ) 1054 - 1054 .

Lydall GJ, Bass NJ, McQuillin A, Lawrence J, Anjorin A, Kandaswamy R, Pereira A, Guerrini I et al. ( 2011 ) . Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder . Psychiatr Genet vol. 21 , ( 6 ) 294 - 306 .

Curtis D ( 2011 ) . Assessing the contribution family data can make to case-control studies of rare variants . Ann Hum Genet vol. 75 , ( 5 ) 630 - 638 .

Pereira ACP, McQuillin A, Puri V, Anjorin A, Bass N, Kandaswamy R, Lawrence J, Curtis D et al. ( 2011 ) . Genetic Association and Sequencing of the Insulin-Like Growth Factor 1 Gene in Bipolar Affective Disorder . AM J MED GENET B vol. 156B , ( 2 ) 177 - 187 .

Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A et al. ( 2011 ) . Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes . Psychiatr Genet vol. 21 , ( 1 ) 1 - 4 .

Curtis D ( 2011 ) . Patient experience - the ingredient missing from cost-effectiveness calculations . Patient Prefer Adherence vol. 5 , 251 - 254 .

Curtis D ( 2010 ) . Confounding factors may account for the association . The BMJ vol. 341 , ( oct13 2 )

Raychaudhuri S, Korn JM, McCarroll SA, Altshuler D, Sklar P, Purcell S, Daly MJ ( 2010 ) . Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function . PLOS Genetics vol. 6 , ( 9 )

Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, Lawrence J, Bass NJ et al. ( 2010 ) . A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia . Mol Psychiatry vol. 15 , ( 6 ) 615 - 628 .

Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N et al. ( 2010 ) . Support of Association Between BRD1 and Both Schizophrenia and Bipolar Affective Disorder . AM J MED GENET B vol. 153B , ( 2 ) 582 - 591 .

COLEMAN RM, CURTIS D ( 2010 ) . Distribution of Risk Behaviour for HIV Infection Amongst Intravenous Drug Users . Addiction vol. 83 , ( 11 ) 1331 - 1334 .

COLEMAN RM, CURTIS D, FEINMANN C ( 2010 ) . Perception of Risk of HIV Infection by Injecting Drug Users and Effects on Medical Clinic Attendance . Addiction vol. 83 , ( 11 ) 1325 - 1329 .

GURLING HMD, CURTIS D, MURRAY RM ( 2010 ) . Psychological deficit from excessive alcohol consumption: evidence from a co‐twin control study . Addiction vol. 86 , ( 2 ) 151 - 155 .

Lydall G, Bass N, McQuillin A, Anjorin A, Kandaswamy R, Pereira AC, Guerrini I, Curtis D et al. ( 2010 ) . CONNECTIVITY GENES IN COMORBID ALCOHOLISM AND BIPOLAR DISORDER . EUROPEAN PSYCHIATRY vol. 25 ,

Lydall G, Worlley K, McQuillin A, Jauhar S, O'Kane A, Rao H, Anjorin A, Guerrini I et al. ( 2010 ) . SEARCHING FOR ALCOHOLISM VULNERABILITY GENES: UK-COGA PROVISIONAL CLINICAL FINDINGS . EUROPEAN PSYCHIATRY . vol. 25 ,

Curtis D, Vine AE ( 2010 ) . Yin yang haplotypes revisited - long, disparate haplotypes observed in European populations in regions of increased homozygosity . Hum Hered vol. 69 , ( 3 ) 184 - 192 .

Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D et al. ( 2009 ) . DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder . MOL PSYCHIATR vol. 14 , ( 9 ) 865 - 873 .

Ng MYM, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paunio T et al. ( 2009 ) . Meta-analysis of 32 genome-wide linkage studies of schizophrenia . MOL PSYCHIATR vol. 14 , ( 8 ) 774 - 785 .

Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Robinson M, Lawrence J, Anjorin A et al. ( 2009 ) . No evidence for excess runs of homozygosity in bipolar disorder . PSYCHIAT GENET vol. 19 , ( 4 ) 165 - 170 .

Kalsi G, Mankoo BS, Curtis D, Brynjolfsson J, Read T, Sharma T, Murphy P, Petursson H et al. ( 2009 ) . Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites . Psychological Medicine vol. 25 , ( 3 ) 531 - 537 .

Bass NJ, Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Quested D et al. ( 2009 ) . Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia . BEHAV BRAIN FUNCT vol. 5 , Article 28 ,

Raychaudhuri S, Plenge RM, Rossin EJ, Ng ACY, Purcell SM, Sklar P, Scolnick EM, Xavier RJ et al. ( 2009 ) . Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions . PLOS Genetics vol. 5 , ( 6 )

McQuillin A, Bass NJ, Choudhury K, Puri V, Kosmin M, Lawrence J, Curtis D, Gurling HMD ( 2009 ) . Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders . MOL PSYCHIATR vol. 14 , ( 6 ) 614 - 620 .

Vine AE, Curtis D ( 2009 ) . Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium . BMC Res Notes vol. 2 ,

Puri V, McQuillin A, Datta S, Choudhury K, Pimm J, Thirumalai S, Krasucki R, Lawrence J et al. ( 2008 ) . Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3 . EUR J HUM GENET vol. 16 , ( 10 ) 1275 - 1282 .

Curtis D ( 2008 ) . Antipsychotics and stroke risk: Effect of antipsychotics on stroke risk remains unproved . BMJ vol. 337 , ( 7671 )

Curtis D ( 2008 ) . Effect of antipsychotics on stroke risk remains unproved . The BMJ vol. 337 , ( sep16 3 )

Curtis D, Gurling H ( 2008 ) . A Procedure for Combining Two-Point Lod Scores into a Summary Multipoint Map . Human Heredity vol. 43 , ( 3 ) 173 - 185 .

Sherrington R, Mankoo B, Dixon M, Curtis D, Kalsi G, Melmer G, Gurling H ( 2008 ) . Microsatellite Polymorphisms for Chromosome 5 Bands q11.2-q13.3 . Human Heredity vol. 43 , ( 3 ) 197 - 202 .

Knight J, Curtis D, Sham PC ( 2008 ) . CLUMPHAP: A simple tool for performing haplotype-based association analysis . GENET EPIDEMIOL vol. 32 , ( 6 ) 539 - 545 .

Ferreira MAR, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G et al. ( 2008 ) . Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder . Nature Genetics vol. 40 , ( 9 ) 1056 - 1058 .

Stone JL, O’Donovan MC, Gurling H, Kirov GK, Blackwood DHR, Corvin A, Craddock NJ, Gill M et al. ( 2008 ) . Rare chromosomal deletions and duplications increase risk of schizophrenia . Nature vol. 455 , ( 7210 ) 237 - 241 .

Curtis D, Vine AE, Knight J ( 2008 ) . Investigation into the ability of SNP chipsets and microsatellites to detect association with a disease locus . Ann Hum Genet vol. 72 , ( Pt 4 ) 547 - 556 .

Rees M, Curtis D, Parker K, Sundqvist A, Baralle D, Bespalova I, Burmeister M, Chung E et al. ( 2008 ) . Linkage Analysis of Idiopathic Generalised Epilepsy in Families of Probands with Juvenile Myoclonic Epilepsy and Marker Loci in the Region of EPM 1 on Chromosome 21 q: Unverricht-Lundborg Disease and JME are not Allelic Variants . Neuropediatrics vol. 25 , ( 01 ) 20 - 25 .

Sklar P, Smoller JW, Fan J, Ferreira MAR, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB et al. ( 2008 ) . Whole-genome association study of bipolar disorder . Molecular Psychiatry vol. 13 , ( 6 ) 558 - 569 .

Curtis D, Vine AE, Knight J ( 2008 ) . Study of regions of extended homozygosity provides a powerful method to explore haplotype structure of human populations . Ann Hum Genet vol. 72 , ( Pt 2 ) 261 - 278 .

Curtis D, Vine AE, Knight J ( 2008 ) . A simple method for assessing the strength of evidence for association at the level of the whole gene . Advances and Applications in Bioinformatics and Chemistry vol. 1 , ( 1 ) 115 - 120 .

Curtis D, Vine AE, Knight J ( 2008 ) . A simple method for assessing the strength of evidence for association at the level of the whole gene . Adv Appl Bioinform Chem vol. 1 , 115 - 120 .

Curtis D ( 2007 ) . Extended homozygosity is not usually due to cytogenetic abnormality . BMC Genet vol. 8 ,

CURTIS D ( 2007 ) . A program to draw pedigrees using LINKAGE or LINKSYS data files . Annals of Human Genetics vol. 54 , ( 4 ) 365 - 367 .

SHAM PC, CURTIS D ( 2007 ) . An extended transmission/disequilibrium test (TDT) for multi‐allele marker loci . Annals of Human Genetics vol. 59 , ( 3 ) 323 - 336 .

CURTIS D ( 2007 ) . Another procedure for the preliminary ordering of loci based on two point lod scores . Annals of Human Genetics vol. 58 , ( 1 ) 65 - 75 .

COOK CCH, GURLING HMD, CURTIS D ( 2007 ) . DOLINK ‐ a computer program to facilitate management of genetic data and analyses . Annals of Human Genetics vol. 57 , ( 4 ) 307 - 310 .

SHAM PC, CURTIS D ( 2007 ) . Monte Carlo tests for associations between disease and alleles at highly polymorphic loci . Annals of Human Genetics vol. 59 , ( 1 ) 97 - 105 .

CURTIS D, SHAM PC ( 2007 ) . Population stratifications can cause false positive linkage results if founders are untyped . Annals of Human Genetics vol. 60 , ( 3 ) 261 - 263 .

CURTIS D, BRYNJOLFSSON J, PETURSSON H, HOLMES S, SHERRINGTON R, BRETT P, RIFKIN L, MURPHY P et al. ( 2007 ) . Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A) . Annals of Human Genetics vol. 57 , ( 1 ) 27 - 39 .

Curtis D, Gurling HMD ( 2007 ) . Using a dummy quantitative variable to deal with multiple affection categories in genetic linkage analysis . Annals of Human Genetics vol. 55 , ( 4 ) 321 - 327 .

CURTIS D, SHAM PC ( 2007 ) . Using risk calculation to implement an extended relative pair analysis . Annals of Human Genetics vol. 58 , ( 2 ) 151 - 162 .

Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, Lawrence J, Pimm J, Bass N et al. ( 2007 ) . Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia . BEHAV BRAIN FUNCT vol. 3 , Article 50 ,

Vine AE, Curtis D, Knight J ( 2007 ) . A simple approach for assessing the strength of evidence for association at the level of the whole gene . GENETIC EPIDEMIOLOGY . vol. 31 , 648 - 649 .

Gurling HMD, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R et al. ( 2007 ) . Gene–Brain Structure Relationships: Arbitrary Assumptions of Heterogeneity Generate Unfalsifiable Claims—Reply . JAMA Psychiatry vol. 64 , ( 9 ) 1098 - 1099 .

Willis M, Low LCM, Parkar S, Curtis D ( 2007 ) . Psychiatry SHOs should consider psychological treatment for depression . International Journal of Health Governance vol. 12 , ( 3 ) 150 - 154 .

Curtis D ( 2007 ) . Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association . BMC Genet vol. 8 ,

Curtis D, Xu K ( 2007 ) . Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics . BMC Genet vol. 8 ,

Curtis D ( 2007 ) . Allelic association studies of genome wide association data can reveal errors in marker position assignments . BMC Genet vol. 8 ,

Curtis D, Vine AE, Knight J ( 2007 ) . A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies . BMC Genet vol. 8 ,

Choudhury K, McQuillin A, Puri V, Pimm J, Datta S, Thirumalai S, Krasucki R, Lawrence J et al. ( 2007 ) . A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia . AM J HUM GENET vol. 80 , ( 4 ) 664 - 672 .

Puri V, McQuillin A, Choudhury K, Datta S, Pimm J, Thirumalai S, Krasucki R, Lawrence J et al. ( 2007 ) . Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene . BIOL PSYCHIAT vol. 61 , ( 7 ) 873 - 879 .

Knight J, Curtis D, Sham PC ( 2007 ) . CLUMPHAP: A simple tool for performing haplotype based association analysis . GENETIC EPIDEMIOLOGY . vol. 31 , 634 - 634 .

North BV, Sham PC, Knight J, Martin ER, Curtis D ( 2006 ) . Investigation of the ability of haplotype association and logistic regression to identify associated susceptibility loci . ANN HUM GENET vol. 70 , 893 - 906 .

Townsend G, Curtis D ( 2006 ) . Case report: rapidly fatal bowel ischaemia on clozapine treatment . BMC Psychiatry vol. 6 , ( 1 )

Choudhury K, McQuillin A, Puri V, Thirumalai S, Lawrence J, Krasucki R, Datta SR, Bass NJ et al. ( 2006 ) . A genetic association study implicates the chromosome 11q23.3 gene FXYD6 in susceptibility to schizophrenia . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 141B , 804 - 804 .

Bass N, McQuillin A, Lawrence J, Choudhury K, Puri V, Kalsi G, Curtis D, Gurling H ( 2006 ) . Failure to confirm allelic association between COMT and bipolar disorder in a large UK sample . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 141B , 749 - 749 .

Kandaswamy R, Bass N, Choudhury K, Puri V, Mcquillin A, Lawrence J, Curtis D, Gurling H ( 2006 ) . Fine mapping of a new bipolar and unipolar affective disorder locus on chromosome 1p36 . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 141B , 747 - 748 .

Kalsi G, McQuillin A, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri V et al. ( 2006 ) . Identification of the slynar gene (AY070435) and related brain expressed sequences as a candidate gene for susceptibility to affective disorders through allelic and haplotypic association with bipolar disorder on chromosome 12q24 . AM J PSYCHIAT vol. 163 , ( 10 ) 1767 - 1776 .

Curtis D, Gurling H ( 2006 ) . Estimation of Haplotypes at DRD2 May Have Produced Misleading Results . JAMA Psychiatry vol. 63 , ( 8 ) 939 - 939 .

Gurling HMD, Critchley H, Datta SR, McQuillin A, Blaveri E, Thirumalai S, Pimm J, Krasucki R et al. ( 2006 ) . Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia . ARCH GEN PSYCHIAT vol. 63 , ( 8 ) 844 - 854 .

Rizig MA, McQuillin A, Puri V, Choudhury K, Datta S, Thirumalai S, Lawrence J, Quested D et al. ( 2006 ) . Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4) . AM J MED GENET B vol. 141B , ( 3 ) 296 - 300 .

Curtis D, Sham PC ( 2006 ) . Estimated haplotype counts from case-control samples cannot be treated as observed counts . AM J HUM GENET vol. 78 , ( 4 ) 729 - 730 .

McQuillan A, Bass NJ, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh SD, Curtis D et al. ( 2006 ) . Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3 . MOL PSYCHIATR vol. 11 , ( 2 ) 134 - 142 .

Puri V, McQuillin A, Thirumalai S, Lawrence J, Krasucki R, Choudhury K, Datta S, Kerwin S et al. ( 2006 ) . Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample . BIOL PSYCHIAT vol. 59 , ( 2 ) 195 - 197 .

McQuillin A, Kalsi G, Degn B, Lundorf MD, Bass NJ, Lawrence J, Choudhury K, Puri VH et al. ( 2005 ) . Allelic and haplotypic association with bipolar disorder implicates a 300 kilobase region on chromosome 12q24.3 containing novel brain expressed gene sequences . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 138B , 32 - 32 .

Datta SR, McQuillin A, Rizig MA, Puri V, Choudhury KH, Thirumalai S, Lawrence J, Bass N et al. ( 2005 ) . Detection of potential aetiological base pair changes causing genetic susceptibility to schizophrenia in the pericentriolar material 1 (PCM1) gene on chromosome 8p22 supports evidence from allelic association . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 138B , 120 - 120 .

Bass N, McQuillin A, Lawrence J, Choudhury, Puri V, Kalsi G, Curtis D, Gurling HM ( 2005 ) . Evidence of allelic association of bipolar disorder with two genes P2RX7 and AY070435 6 MB apart on 12q24 . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 138B , 74 - 74 .

Choudhury KH, Rizig MA, McQuillin A, Puri V, Datta SR, Thirumalai S, Lawrence J, Bass N et al. ( 2005 ) . Genetic association and gene expression studies implicate the chromosome 11q23.3 gene FXYD2 in susceptibility to schizophrenia . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 138B , 118 - 118 .

Curtis D, Knight J, Sham PC ( 2005 ) . Program Report: GENECOUNTING Support Programs . Annals of Human Genetics vol. 70 , ( 2 ) 277 - 279 .

Curtis D, Knight J, Sham PC ( 2005 ) . A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees . Psychiatr Genet vol. 15 , ( 3 ) 181 - 187 .

Kalsi G, Brynjolfsson J, Butler R, Sherrington R, Curtis D, Sigmundsson T, Read T, Murphy P et al. ( 2005 ) . Linkage analysis of chromosome 22q12–13 in a United Kingdom/Icelandic sample of 23 multiplex schizophrenia families . American Journal of Medical Genetics vol. 60 , ( 4 ) 298 - 301 .

Lim LCC, Gurling H, Curtis D, Brynjolfsson J, Petursson H, Gill M ( 2005 ) . Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees . American Journal of Medical Genetics vol. 48 , ( 4 ) 223 - 228 .

Vincent JB, Melmer G, Bolton PF, Hodgkinson S, Holmes D, Curtis D, Gurling HMD ( 2005 ) . Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region . Psychiatric Genetics vol. 15 , ( 2 ) 83 - 90 .

Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H et al. ( 2005 ) . The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia . AM J HUM GENET vol. 76 , ( 5 ) 902 - 907 .

Guerrini I, Cook CCH, Kest W, Devitgh A, McQuillin A, Curtis D, Gurling HMD ( 2005 ) . Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2 . BMC GENET vol. 6 , Article 11 ,

North BV, Curtis D, Sham PC ( 2005 ) . Application of logistic regression to case-control association studies involving two causative loci . HUM HERED vol. 59 , ( 2 ) 79 - 87 .

Rizig MA, McQuillin A, Datta SR, Pimm J, Thirumalai S, Moorey H, Quested DD, Kalsi G et al. ( 2004 ) . A microarray gene expression and genetic association study of the RGS4 gene in schizophrenia . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 26 - 26 .

Choudhury K, Puri V, McQuillin A, Kalsi G, Bass N, Lawrence J, Curtis D, Gurling HMD ( 2004 ) . Attempted confirmation of the fine mapping of a putative bipolar susceptibility locus on chromosome 4P16.1 at the PPP2R2C gene locus . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 49 - 49 .

Puri V, Rizig MA, Datta SR, McQuillin A, Thirumalai S, Pimm J, Moorey H, Quested D et al. ( 2004 ) . Fine mapping of the chromosome 1q23-24.2 schizophrenia susceptibility region near the RGS4 D1S196 and Capon loci . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 129 - 129 .

Curtis D ( 2004 ) . Re-analysis of collaborative study on the genetics of alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299 . Psychiatr Genet vol. 14 , ( 3 ) 151 - 155 .

Curtis D, Brett P, Dearlove AM, McQuillin A, Kalsi G, Robertson MM, Gurling HMD ( 2004 ) . Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13 . PSYCHIAT GENET vol. 14 , ( 2 ) 83 - 87 .

North BV, Curtis D, Martin ER, Lai EH, Roses AD, Sham PC ( 2004 ) . Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci . Ann Hum Genet vol. 68 , ( Pt 3 ) 240 - 248 .

Sham PC, Rijsdijk FV, Knight J, Makoff A, North B, Curtis D ( 2004 ) . Haplotype association analysis of discrete and continuous traits using mixture of regression models . BEHAV GENET vol. 34 , ( 2 ) 207 - 214 .

Datta SR, Mcqullin A, Rizig MA, Thirumalai S, Pimm J, Moorey H, Quested D, Kalsi G et al. ( 2004 ) . Further genetic analyses of the PCM1 gene association with schizophrenia on chromosome 8p21 and tests of the G72, Dysbindin, RGS4, calcineurin, comt, frizzled 3, MRDS1, AKT1 and CAPON associations . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 86 - 86 .

Kalsi G, McQuillan A, Degn B, Lundforf MD, Lawrence J, Curtis D, Kruse T, Gurling H et al. ( 2004 ) . Identification of a locus increasing genetic susceptibility to bipolar affective disorder on chromosome 12q24.3 in both British/Irish and Danish case-control association samples . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 42 - 42 .

McQuillin A, Bass N, Kalsi G, Lawrence J, Smyth C, Curtis D, Gurling HMD ( 2004 ) . Resequencing of the TRPM2 and TSPEAR genes provides additional SNPs in the 21q22.3 region of chromosome 21 that show strengthened allelic and haploptypic association with bipolar disorder . AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS . vol. 130B , 35 - 35 .

Knight J, North BV, Sham PC, Curtis D ( 2003 ) . Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait . BMC GENETICS . vol. 4 ,

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ciclitira PJ ( 2003 ) . Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region . EUR J IMMUNOGENET vol. 30 , ( 6 ) 427 - 432 .

North BV, Curtis D, Cassell PG, Hitman GA, Sham PC ( 2003 ) . Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes . Ann Hum Genet vol. 67 , ( Pt 4 ) 348 - 356 .

Curtis D, Kalsi G, Brynjolfsson J, McInnis M, O'Neill J, Smyth C, Moloney E, Murphy P et al. ( 2003 ) . Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q . PSYCHIAT GENET vol. 13 , ( 2 ) 77 - 84 .

SHAM PC, ZHAO JH, CURTIS D ( 2003 ) . Optimal weighting scheme for affected sib‐pair analysis of sibship data . Annals of Human Genetics vol. 61 , ( 1 ) 59 - 67 .

Carbonell J, Allen R, Kalsi G, McQuillin A, Livingston G, Katona C, Walker Z, Katz A et al. ( 2003 ) . Variation in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease . Psychiatric Genetics vol. 13 , ( 1 ) 47 - 50 .

North BV, Curtis D, Sham PC ( 2003 ) . A note on the calculation of empirical P values from Monte Carlo procedures . AM J HUM GENET vol. 72 , ( 2 ) 498 - 499 .

Guerrini I, Cook CH, Kest W, Devitgh A, McQuillin A, Curtis D, Gurling HMD ( 2002 ) . Genome scan of alcoholism in multiplex British families supports the presence of susceptibility loci on chromosome 1p and 1q . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 114 , 717 - 718 .

Bass N, McQuillin A, Lawrence J, Darragh N, Kalsi G, Curtis D, Gurling HMD ( 2002 ) . Investigation of the gene encoding tryptophan hydroxylase (TPH) and suicide behaviour in bipolar affective disorder shows allelic association with poor pre-morbid social and work adjustment and with violent suicide . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 114 , 755 - 755 .

McQuillin A, Kalsi G, Lawrence J, Smyth C, Curtis D, Bass N, Gurling HMD ( 2002 ) . Positive allelic association of the marker D21S171 with bipolar disorder identifies TRPC7, a calcium channel protein on chromosome 21 at 21q22.3, as being a candidate gene for increasing susceptibility to bipolar and related unipolar affective disorders . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 114 , 721 - 721 .

McQuillin A, Kalsi G, Lawrence J, Smyth C, Curtis D, Bass NJ, Gurling HMD ( 2002 ) . Positive allelic association of the marker d21sl71 with bipolar disorder identifies TRPC7, a calcium channel protein on chromosome 21 at 21q22.3, as being a candidate gene for increasing genetic susceptibility to bipolar and related unipolar affective disorders . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 488 - 488 .

Hassan Z, Mohan V, Ali L, Allotey R, Barakat K, Faruque MO, Deepa R, McDermott MF et al. ( 2002 ) . SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent . Am J Hum Genet vol. 71 , ( 4 ) 964 - 968 .

North BV, Curtis D, Sham PC ( 2002 ) . A note on the calculation of empirical P values from Monte Carlo procedures . AM J HUM GENET vol. 71 , ( 2 ) 439 - 441 .

McQuillin A, Kalsi G, Moorey H, Lamb G, Mayet S, Quested D, Baker P, Curtis D et al. ( 2002 ) . A novel polymorphism in exon 11 of the WKL1 gene, shows no association with schizophrenia . EUR J HUM GENET vol. 10 , ( 8 ) 491 - 494 .

Moodie SJ, Norman PJ, King AL, Fraser JS, Curtis D, Ellis HJ, Vaughan RW, Ciclitira PJ ( 2002 ) . Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters . EUR J IMMUNOGENET vol. 29 , ( 4 ) 287 - 291 .

Curtis D, North BV, Gurling HMD, Blaveri E, Sham PC ( 2002 ) . A quick and simple method for detecting subjects with abnormal genetic background in case-control samples . ANN HUM GENET vol. 66 , 235 - 244 .

Cassell PG, Jackson AE, North BV, Evans JC, Syndercombe-Court D, Phillips C, Ramachandran A, Snehalatha C et al. ( 2002 ) . Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians . Diabetes vol. 51 , ( 5 ) 1622 - 1628 .

Taske NL, Williamson MP, Makoff A, Bate L, Curtis D, Kerr M, Kjeldsen MJ, Pang KA et al. ( 2002 ) . Evaluation of the positional candidate gene CHRNA7 at the juvenile myoclonic epilepsy locus (EJM2) on chromosome 15q13-14 . EPILEPSY RES vol. 49 , ( 2 ) 157 - 172 .

Curtis D, North BV, Sham PC ( 2002 ) . Extension of conditional model-free likelihood-based linkage analysis to additive and other models . ANN HUM GENET vol. 66 , 157 - 167 .

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ ( 2002 ) . CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families . J MED GENET vol. 39 , ( 1 ) 51 - 54 .

Gurting HMD, Blaveri E, Datta S, Kalsi G, Lawrence J, Quested D, Moorey H, Lamb G et al. ( 2002 ) . Evidence for allelic association between three chromosome 8p21.3-22 markers and schizophrenia points to the brain expressed microtubule associated protein gene, Pericentriolar Material (PCM1) as a candidate for increasing genetic liability to schizophrenia . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 469 - 469 .

Gurling HMD, Blaveri E, Datta S, Kalsi G, McQuillin A, Moorey H, Quested D, Lamb G et al. ( 2002 ) . Genetic markers showing linkage disequilibrium with a chromosome 8p22 schizophrenia susceptibility locus near the pericentriolar material gene (PCM1) are associated with reduced left orbitofrontal cortex grey matter volume and other cerebral morphology changes at MRI compared to non chromosome 8p22 associated schizophrenics . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 114 , 747 - 747 .

Blaveri E, Critchley HD, Gurling HMD, O'Daly O, Kalsi G, Datta SR, McQuillin A, Moorey H et al. ( 2002 ) . Genetic markers showing linkage disequilibrium with a chromosome 8p22 schizophrenia susceptibility locus near the pericentriolar material gene (PCM1) are associated with reduced left orbitofrontal cortex grey matter volume and other cerebral morphology changes at MRI compared to non chromosome 8p22 associated schizophrenics . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 71 , 469 - 469 .

Kalsi G, Lawrence J, Mcquillin A, Curtis D, Bass N, Gurling HMD ( 2002 ) . X linkage in bipolar disorder: Allelic association studies of the Xq26-28 region implicate the G6PD locus and flanking region but not the a3 subunit of the GABA receptor gene (GABRA3) in a UK bipolar case-control sample . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 114 , 764 - 764 .

Guerrini I, Cook CCH, Kest W, Devitgh A, McQuillin A, Kalsi G, Curtis D, Gurling HMD ( 2001 ) . Systematic genome scan of alcoholism using genetic linkage analysis in multiplex British families supports the presence of susceptibility loci on chromosome 1p and 16p . AM J HUM GENET vol. 69 , ( 4 ) 498 - 498 .

Curtis D, North BV, Sham PC ( 2001 ) . A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease . ANN HUM GENET vol. 65 , 473 - 482 .

King AL, Fraser JS, Moodie SJ, Curtis D, Reid E, Dearlove AM, Ciclitira PJ ( 2001 ) . CTLA-4 gene polymorphisms and susceptibility to coeliac disease . J MED GENET vol. 38 , S67 - S67 .

Curtis D ( 2001 ) . Antidepressants and counselling for major depression in primary care. Counselling is not demonstrably as effective as drug treatment for depression . BMJ vol. 323 , ( 7307 ) 282 - 283 .

Blaveri E, Kalsi G, Lawrence J, Quested D, Moorey H, Lamb G, Kohen D, Shiwach R et al. ( 2001 ) . Genetic association studies of schizophrenia using the 8p21-22 genes: prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CHRNA2) and arylamine N-acetyltransferase 1 (NAT1) . European Journal of Human Genetics vol. 9 , ( 6 ) 469 - 472 .

King AL, Fraser JS, Moodle SJ, Curtis D, Dearlove AM, Ellis HJ, Rosen-Bronson S, Ciclitira PJ ( 2001 ) . Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11 . ANN HUM GENET vol. 65 , 377 - 386 .

King AL, Fraser JS, Moodie SJ, Curtis D, Dearlove AM, Ellis HJ, Rosen-Bronson S, Ciclitira PJ ( 2001 ) . Follow-up linkage study of coeliac disease: Further evidence for the existence of a susceptibility locus on chromosome 11p11 . GUT vol. 48 , A77 - A78 .

Gurling HMD, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P et al. ( 2001 ) . Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23 . AM J HUM GENET vol. 68 , ( 3 ) 661 - 673 .

Glazer NB, Cheatham WW ( 2001 ) . Thiazolidinediones for type 2 diabetes . The BMJ vol. 322 , ( 7280 )

Curtis D, North BV, Sham PC ( 2001 ) . A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease . Annals of Human Genetics vol. 65 , ( 5 ) 473 - 482 .

Curtis D, North BV, Sham PC ( 2001 ) . Use of an artificial neural network to detect association between a disease and multiple marker genotypes . ANN HUM GENET vol. 65 , 95 - 107 .

Mynett-Johnson L, Kealey C, Claffey E, Curtis D, Bouchier-Hayes L, Powell C, McKeon P ( 2000 ) . Multimarkerhaplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder . AM J MED GENET vol. 96 , ( 6 ) 845 - 849 .

King AL, Yiannakou JY, Brett PM, Curtis D, Morris MA, Dearlove AM, Rhodes M, Rosen-Bronson S et al. ( 2000 ) . A genome-wide family-based linkage study of coeliac disease . Annals of Human Genetics vol. 64 , ( 6 ) 479 - 490 .

Sham PC, Zhao JH, Waldman I, Curtis D ( 2000 ) . Should ambiguous trios for the TDT be discarded? . Annals of Human Genetics vol. 64 , ( 6 ) 575 - 576 .

Curtis D, Salonen JT, Tuomainen TP, Kontula K ( 2000 ) . C282Y mutation and type 2 diabetes . BMJ vol. 321 , ( 7271 )

King AL, Yiannakou JY, Brett PM, Curtis D, Morris MA, Dearlove AM, Rhodes M, Rosen-Bronson S et al. ( 2000 ) . A genome-wide family-based linkage study of coeliac disease . ANN HUM GENET vol. 64 , 479 - 490 .

Sham PC, Zhao JH, Waldman I, Curtis D ( 2000 ) . Should ambiguous trios for the TDT be discarded? . ANN HUM GENET vol. 64 , 575 - 576 .

Degn B, Lundorf MD, Bruun TG, McQuillin A, Lawrence J, Curtis D, Kalsi G, Chen A et al. ( 2000 ) . A search for the risk allele for bipolar affective disorder on chromosome 12q24.2 . AM J MED GENET vol. 96 , ( 4 ) 545 - 546 .

Gurling HMD, Curtis D, Kalsi G, McQuillan A, Lawrence J, Murphy P, Brynjolfsson J, McInnis M et al. ( 2000 ) . Genome wide linkage anlaysis supports the presence of two separate susceptibility loci on chromosome 1q32 for biopolar disorder and 1q21-22.3 for schizophrenia . AM J MED GENET vol. 96 , ( 4 ) 460 - 460 .

Mynett-Johnson L, Kealey C, Claffey E, Curtis D, McKeon P ( 2000 ) . Multi-marker haplotypes reveal evidence of an association between bipolar disorder and 5-HTT . American Journal of Medical Genetics - Neuropsychiatric Genetics vol. 96 , ( 4 )

Guerrini I, Cook CC, Kest W, Devitgh A, McQuillin A, Holmes D, Turner A, Curtis D et al. ( 2000 ) . Report of a total genome scan for genes increasing susceptibility to alcoholism by genetic linkage analysis in multiplex British families . AM J MED GENET vol. 96 , ( 4 ) 462 - 463 .

Ogunkolade WB, Ramachandran A, McDermott MF, Kumarajeewa TR, Curtis D, Snehalatha C, Mohan V, Cassell PG et al. ( 2000 ) . Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India . DIABETES METAB RES vol. 16 , ( 4 ) 276 - 280 .

Sham PC, Lin M-W, Zhao JH, Curtis D ( 2000 ) . Power Comparison of Parametric and Nonparametric Linkage Tests in Small Pedigrees . American Journal of Human Genetics vol. 66 , ( 5 ) 1661 - 1668 .

Zhao JH, Curtis D, Sham PC ( 2000 ) . Model-free analysis and permutation tests for allelic associations . HUM HERED vol. 50 , ( 2 ) 133 - 139 .

Sham PC, Zhao JH, Curtis D ( 2000 ) . The effect of marker characteristics on the power to detect linkage disequilibrium due to single or multiple ancestral mutations . ANN HUM GENET vol. 64 , 161 - 169 .

Morris MA, Yiannakou JY, King AL, Brett PM, Biagi F, Vaughan R, Curtis D, Ciclitira PJ ( 2000 ) . Coeliac disease and Down syndrome: Associations not due to genetic linkage on chromosome 21 . SCAND J GASTROENTERO vol. 35 , ( 2 ) 177 - 180 .

Kalsi G, Gamble D, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P et al. ( 1999 ) . No evidence for linkage of schizophrenia to DXS7 at chromosome Xp11 . PSYCHIATR GENET vol. 9 , ( 4 ) 197 - 199 .

McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Hannesdottir S, Gurling H ( 1999 ) . Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder . PSYCHOL MED vol. 29 , ( 6 ) 1449 - 1454 .

Curtis D ( 1999 ) . Cognitive therapy is no better than supportive counselling in schizophrenia . The BMJ vol. 319 , ( 7210 )

McQuillin A, Lawrence J, Kalsi G, Smyth C, Curtis D, Gurling HMD ( 1999 ) . An allelic association study of multiple polymorphic markers in the chromosome 21q22.3 region implicated in bipolar affective disorder . MOL PSYCHIATR vol. 4 , S76 - S76 .

Degn B, Bruun TG, McQuillin A, Lawrence J, Curtis D, Kalsi G, Chen A, Kruse TA et al. ( 1999 ) . Association study between patients with bipolar disorder and markers from the candidate region on chromosome 12q24.2-12q24.3 . MOL PSYCHIATR vol. 4 , S71 - S71 .

Curtis D, Kalsi G, McQuillin A, Lawrence J, Murphy P, Brynjolfsson T, McInnis M, Sigmundsson T et al. ( 1999 ) . Genome wide parametric genetic linkage analysis of bipolar and related unipolar affective disorders (manic depression) implicates chromosomes 1 and 12 . MOL PSYCHIATR vol. 4 , S70 - S71 .

Gurling HMD, Kalsi G, Blaveri E, McQuillin A, Read T, Murphy P, Butler R, Brynjolfsson J et al. ( 1999 ) . Initial genome wide parametric genetic linkage analysis of schizophrenia and schizophrenia spectrum disorders finds lod scores above 3.00 on four chromosomes at 1Q22-23, 5Q22-35, 8P21-23 and 11Q14-24. a further lod above 3.00 at 4Q21-31 was found within a single family . MOL PSYCHIATR vol. 4 , S4 - S4 .

Blaveri K, Kalsi G, McQuillin A, Quested D, Read T, Murphy P, Brynjolfsson J, Sigmundsson T et al. ( 1999 ) . Linkage and allelic association studies of the 8p schizophrenia locus . MOL PSYCHIATR vol. 4 , S31 - S31 .

Curtis D ( 1999 ) . Chromosome 21 Workshop . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 88 , 272 - 275 .

Curtis D ( 1999 ) . Chromosome 21 workshop . American Journal of Medical Genetics - Neuropsychiatric Genetics . vol. 88 , 272 - 275 .

Curtis D, Miller MB, Sham PC ( 1999 ) . Combining the sibling disequilibrium test and transmission disequilibrium test for Multiallelic markers . AM J HUM GENET vol. 64 , ( 6 ) 1785 - 1786 .

Zhao JH, Sham PC, Curtis D ( 1999 ) . A program for the Monte Carlo evaluation of significance of the extended transmission/disequilibrium test . AM J HUM GENET vol. 64 , ( 5 ) 1484 - 1485 .

Brett PM, Yiannakou JY, Morris MA, Vaughan R, Curtis D, Ciclitira PJ ( 1999 ) . Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease . ANN HUM GENET vol. 63 , 217 - 225 .

Kalsi G, Mankoo B, Curtis D, Sherrington R, Melmer G, Brynjolfsson J, Sigmundsson T, Read T et al. ( 1999 ) . New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families . ANN HUM GENET vol. 63 , 235 - 247 .

Yiannakou JY, Brett PM, Morris MA, Curtis D, Mathew C, Vaughan R, Rosen-Bronson S, Ciclitira PJ ( 1999 ) . Family linkage study of the T-cell receptor genes in coeliac disease . Digestive and Liver Disease vol. 31 , ( 3 ) 198 - 201 .

Curtis D, Tarrier N ( 1999 ) . Intensive cognitive behaviour therapy for chronic schizophrenia . The BMJ vol. 318 , ( 7179 )

Curtis D, Zhao JH, Sham PC ( 1999 ) . Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data . GENETIC EPIDEMIOLOGY . vol. 17 , S115 - S120 .

McQuillin A, Lawrence J, Kalsi G, Chen A, Gurling H, Curtis D ( 1999 ) . No allelic association between bipolar affective disorder and the tryptophan hydroxylase gene . JAMA Psychiatry vol. 56 , ( 1 ) 99 - 101 .

Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray R, McGuffin P, Nanko S et al. ( 1998 ) . A combined analysis of D22S278 marker alleles in affected sib‐pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12 . American Journal of Medical Genetics vol. 67 , ( 1 ) 40 - 45 .

Wildenauer DB, Schwab SG, Albus M, Hallmayer J, Lerer B, Maier W, Blackwood D, Muir W et al. ( 1998 ) . Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study . American Journal of Medical Genetics vol. 67 , ( 6 ) 580 - 594 .

Goldin LR, Gershon ES, Berrettini WH, Stine OC, DePaulo R, McMahon F, Meyers D, Nothen M et al. ( 1997 ) . Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets . Genetic Epidemiology . vol. 14 , 563 - 568 .

Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P et al. ( 1998 ) . Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5 . American Journal of Medical Genetics vol. 74 , ( 1 ) 50 - 52 .

McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Gurling HMD ( 1998 ) . An allelic association study of candidate genes in the chromosome 21q22.3 region implicated in bipolar affective disorder . AM J MED GENET vol. 81 , ( 6 ) 544 - 544 .

McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Gurling HMD ( 1998 ) . No allelic association between bipolar affective disorder and the tryptophan hydroxylase gene (TPH) . AM J MED GENET vol. 81 , ( 6 ) 513 - 513 .

McQuillin A, Lawrence J, Curtis D, Kalsi G, Smyth C, Gurling HMD ( 1998 ) . No linkage found between chromosome 11p15.5 markers and manic-depressive illness . AM J MED GENET vol. 81 , ( 6 ) 540 - 540 .

Curtis D ( 1998 ) . Genetic epidemiology of binging and vomiting . BRIT J PSYCHIAT vol. 173 , 439 - 439 .

Vallada H, Curtis D, Sham P, Kunugi H, Zhao JH, Murray R, McGuffin P, Nanko S et al. ( 1998 ) . A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q12 . SCHIZOPHR RES vol. 32 , ( 2 ) 115 - 121 .

McDermott MF, McDermott EM, Quane KA, Jones LC, Ogunkolade BW, Curtis D, Waldron-Lynch F, Phelan M et al. ( 1998 ) . Exclusion of the familial Mediterranean fever locus as a susceptibility region for autosomal dominant familial Hibernian fever . J MED GENET vol. 35 , ( 5 ) 432 - 434 .

Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, Cardno A, Asherson P et al. ( 1998 ) . A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia . Molecular Psychiatry vol. 3 , ( 2 ) 141 - 149 .

Brett PM, Yiannakou JY, Morris MA, Bronson SR, Mathew C, Curtis D, Ciclitira PJ ( 1998 ) . A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings . ANN HUM GENET vol. 62 , 25 - 32 .

Curtis D ( 1998 ) . Efficient strategies for genome scanning with affected sib pairs . AM J HUM GENET vol. 62 , ( 1 ) 204 - 205 .

Vallada HP, Vasques L, Curtis D, Zatz M, Kirov G, Lauriano V, Gentil V, Murray RM et al. ( 1998 ) . Linkage analysis between bipolar affective disorder and markers on chromosome X . PSYCHIAT GENET vol. 8 , ( 3 ) 183 - 186 .

Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Petursson H, Butler R, Read T, Murphy P et al. ( 1998 ) . Tests of linkage, allelic and genotypic association between schizophrenia and the gene for the D3 dopamine receptor, DRD3 . PSYCHIAT GENET vol. 8 , ( 3 ) 187 - 189 .

CURTIS D ( 1998 ) . Use of siblings as controls in case-control association studies . Annals of Human Genetics vol. 62 , ( 1 ) 89 - 89 .

Smyth C, Kalsi G, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P et al. ( 1997 ) . Test of Xq26.3-28 linkage In bipolar and unipolar affective disorder in families selected for absence of male to male transmission . BRIT J PSYCHIAT vol. 171 , 578 - 581 .

Brett PM, Curtis D, Robertson MM, Gurling HMD ( 1997 ) . Neuroreceptor subunit genes and the genetic susceptibility to gilles de la tourette syndrome . Biological Psychiatry vol. 42 , ( 10 ) 941 - 947 .

Li T, Vallada H, Curtis D, Arranz M, Xu K, Cai GQ, Deng H, Liu J et al. ( 1997 ) . Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder . PHARMACOGENETICS vol. 7 , ( 5 ) 349 - 353 .

Kalsi G, Smyth C, Brynjolfsson J, Sherrington RS, ONeill J, Curtis D, Rifkin L, Murphy P et al. ( 1997 ) . Linkage analysis of manic depression (bipolar affective disorder) in Icelandic and British kindreds using markers on the short arm of chromosome 18 . HUM HERED vol. 47 , ( 5 ) 268 - 278 .

McDermott MF, Ramachandran A, Ogunkolade BW, Aganna E, Curtis D, Boucher BJ, Snehalatha C, Hitman GA ( 1997 ) . Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians . DIABETOLOGIA vol. 40 , ( 8 ) 971 - 975 .

Elmslie FV, Rees M, Williamson MP, Kerr M, Kjeldsen MJ, Pang KA, Sundqvist A, Friis ML et al. ( 1997 ) . Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q . HUM MOL GENET vol. 6 , ( 8 ) 1329 - 1334 .

Curtis D ( 1997 ) . Use of siblings as controls in case-control association studies . ANN HUM GENET vol. 61 , 319 - 333 .

Kellett JM, Curtis D ( 1997 ) . Suspension of nurse who gave drug on consultant's instructions . The BMJ vol. 314 , ( 7086 )

Curtis D ( 1997 ) . Suspension of nurse who gave drug on consultant's instructions. Patients should be alert to doctors' willingness to use subterfuge to give drugs . The BMJ vol. 314 , ( 7086 ) 1043 - 1044 .

Fleminger S, Curtis D ( 1997 ) . Prion diseases . BRIT J PSYCHIAT vol. 170 , 103 - 105 .

Smyth C, Kalsi G, Curtis D, Brynjolfsson J, ONeill J, Rifkin L, Moloney E, Murphy P et al. ( 1997 ) . Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22 . GENOMICS vol. 39 , ( 3 ) 271 - 278 .

Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P, Petursson H et al. ( 1997 ) . A linkage study between a D3 dopamine receptor (DRD3) gene polymorphism and schizophrenia . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 74 , 626 - 626 .

Goldin LR, Gershon ES, Berrettini WH, Stine OC, DePaulo R, McMahon F, Meyers D, Nothen M et al. ( 1997 ) . Description of the genetic analysis workshop 10 bipolar disorder linkage data sets . Genetic Epidemiology . vol. 14 , 563 - 568 .

Chen AC-H, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P et al. ( 1997 ) . Exclusion of linkage of schizophrenia of the gene for the glutamate GluR5 receptor . Biological Psychiatry vol. 41 , ( 2 ) 243 - 245 .

Lawrence J, Kalsi G, Hannesdottir S, Smyth C, Brynjolfsson J, Curtis D, Petursson H, Gurling HMD ( 1997 ) . Further tests of allelic association and transmission disequilibrium between the tyrosine hydroxylase gene locus on chromosome 11p15 with bipolar and related unipolar affective disorders in familial and case-control samples . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 74 , 669 - 670 .

Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P, Petursson H et al. ( 1997 ) . Linkage analysis of the beta-1 GABAA receptor subunit gene locus in the genetic susceptibility to schizophrenia in British and Icelandic families . AMERICAN JOURNAL OF MEDICAL GENETICS . vol. 74 , 635 - 636 .

Smyth C, Kalsi G, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P et al. ( 1997 ) . Test of Xq26.3-28 linkage in bipolar and unipolar affective disorder in families selected for absence of male to male transmission . British Journal of Psychiatry vol. 171 , ( DEC. ) 578 - 581 .

Chen AC, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P et al. ( 1996 ) . Lack of evidence for close linkage of the glutamate GluR6 receptor gene with schizophrenia . American Journal of Psychiatry vol. 153 , ( 12 ) 1634 - 1636 .

Vallada H, Craddock N, Vasques L, Curtis D, Kirov G, Lauriano V, Gentil V, Passos-Bueno R et al. ( 1996 ) . Linkage studies in bipolar affective disorder with markers on chromosome 21 . Journal of Affective Disorders vol. 41 , ( 3 ) 217 - 221 .

Kunugi H, Curtis D, Vallada HP, Nanko S, Powell JF, Murray RM, McGuffin P, Owen MJ et al. ( 1996 ) . A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families . Schizophrenia Research vol. 22 , ( 1 ) 61 - 68 .

Collier DA, Barrett TG, Curtis D, Macleod A, Arranz JM, Maassen JA, Bundey S ( 1996 ) . Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity . AM J HUM GENET vol. 59 , ( 4 ) 855 - 863 .

Cook CCH, Palsson G, Turner A, Holmes D, Brett P, Curtis D, Petursson H, Gurling HMD ( 1996 ) . A genetic linkage study of the D-2 dopamine receptor locus in heavy drinking and alcoholism . BRIT J PSYCHIAT vol. 169 , ( 2 ) 243 - 248 .

( 1996 ) . Erratum: Schizophrenia susceptibility and chromosome 6p24-22 . Nature Genetics vol. 13 , ( 1 ) 129 - 129 .

Sham PC, Curtis D, MacLean CJ ( 1996 ) . Likelihood ratio tests for linkage and linkage disequilibrium: asymptotic distribution and power . American Journal of Human Genetics vol. 58 , ( 5 ) 1093 - 1096 .

Curtis D ( 1996 ) . Sigmund Freud . The Lancet vol. 347 , ( 9007 ) 1040 - 1041 .

Curtis D ( 1996 ) . Cardiovascular disease risk . Nature Medicine vol. 2 , ( 4 ) 365 - 366 .

Curtis D ( 1996 ) . Genetic dissection of complex traits . NAT GENET vol. 12 , ( 4 ) 356 - 357 .

Pearce JMS, Kaminer H, Hasenöhrl N, Fonagy P, Reed G, Curtis D, Tallis R ( 1996 ) . Sigmund Freud . The Lancet vol. 347 , ( 9007 ) 1039 - 1041 .

Smyth C, Kalsi G, Brynjolfsson J, O'Neill J, Curtis D, Rifkin L, Moloney E, Murphy P et al. ( 1996 ) . Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139] . American Journal of Psychiatry vol. 153 , ( 2 ) 271 - 274 .

Chung E, Curtis D, Chen G, Marsden PA, Twells R, Xu W, Gardiner M ( 1996 ) . Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis . American Journal of Human Genetics vol. 58 , ( 2 ) 363 - 370 .

Curtis D ( 1996 ) . Defending attacks on statistics . Nature Medicine vol. 2 , ( 1 ) 4 - 4 .

Lin MW, Curtis D, Williams N, Arranz M, Nanko S, Collier D, McGuffin P, Murray R et al. ( 1996 ) . Erratum: Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32 (Psychiatric Genetics (1995) 5 (117-126) . Psychiatric Genetics vol. 6 , ( 1 )

Chen AC-H, Kalsi G, Brynjolfsson J, Sigmundsson T, Curtis D, Butler R, Read T, Murphy P et al. ( 1996 ) . Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5 . Psychiatric Genetics vol. 6 , ( 3 )

Kalsi G, Curtis D, Brynjolfsson J, Sigmundsson T, Butler R, Read T, Murphy P, Petursson H et al. ( 1996 ) . Exclusion of linkage between schizophrenia and the putative chromosome 3p24-p26 susceptibility locus . Psychiatric Genetics vol. 6 , ( 3 )

Brett PM, Curtis D, Robertson MM, Dahlitz M, Gurling HMD ( 1996 ) . Linkage analysis and exclusion of regions of chromosomes 3 and 8 in Gilles de la Tourette syndrome following the identification of a balanced reciprocal translocation 46 XY, t(3 . Psychiatric Genetics vol. 6 , ( 3 ) 99 - 106 .

Kalsi G, Sherrington R, Mankoo BS, Brynjolfsson J, Sigmundsson T, Curtis D, Read T, Murphy P et al. ( 1996 ) . Linkage study of the D5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees . American Journal of Psychiatry vol. 153 , ( 1 ) 107 - 109 .

Lin MW, Curtis D, Williams N, Arranz M, Nanko S, Collier D, McGuffin P, Murray R et al. ( 1996 ) . Suggestive evidence for linkage of schizophrenia to markers on chromosome (vol 5, pg 117, 1995) . PSYCHIATRIC GENETICS vol. 6 , ( 1 ) U3 - U3 .

Sodhi MS, Arranz MJ, Curtis D, Ball DM, Sham P, Roberts GW, Price J, Collier DA et al. ( 1995 ) . Association between clozapine response and allelic variation in the 5-HT2C receptor gene . Neuroreport vol. 7 , ( 1 ) 169 - 172 .

Gurling H, Kalsi G, Hui-Sui Chen A, Green M, Butler R, Read T, Murphy P, Curtis D et al. ( 1995 ) . Schizophrenia susceptibility and chromosome 6p24–22 . Nature Genetics vol. 11 , ( 3 ) 234 - 235 .

Curtis D ( 1995 ) . Standardized pedigree nomenclature . American Journal of Human Genetics vol. 57 , ( 4 ) 982 - 984 .

Curtis D ( 1995 ) . Euthanasia . Nature Medicine vol. 1 , ( 9 ) 849 - 850 .

Curtis D, Sham PC ( 1995 ) . Model-free linkage analysis using likelihoods . American Journal of Human Genetics vol. 57 , ( 3 ) 703 - 716 .

Gurling H, Smyth C, Kalsi G, Moloney E, Rifkin L, O'Neill J, Murphy P, Curtis D et al. ( 1995 ) . Linkage findings in bipolar disorder . Nature Genetics vol. 10 , ( 1 ) 8 - 9 .

Brett PM, Curtis D, Robertson MM, Gurling HMD ( 1995 ) . The genetic susceptibility to Gilles de la Tourette Syndrome in a large multiple affected british kindred: Linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase . Biological Psychiatry vol. 37 , ( 8 ) 533 - 540 .

Curtis D, Sham PC ( 1995 ) . A note on the application of the transmission disequilibrium test when a parent is missing . American Journal of Human Genetics vol. 56 , ( 3 ) 811 - 812 .

Brett PM, Curtis D, Robertson MM, Gurling HM ( 1995 ) . Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette's syndrome, chronic motor tics, and obsessive-compulsive behavior . American Journal of Psychiatry vol. 152 , ( 3 ) 437 - 440 .

Vallada H, Curtis D, Sham PC, Murray RM, McGuffin P, Nanko S, Gill M, Owen M et al. ( 1995 ) . Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia . Psychiatric Genetics vol. 5 , ( 3 ) 127 - 130 .

Curtis D, Sham PC, Vallada HP ( 1995 ) . Genetic analysis of complex disease . Nature Genetics vol. 9 , ( 1 ) 13 - 13 .

Dawson E, Gill M, Curtis D, Castle D, Hunt N, Murray R, Powell J ( 1995 ) . Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder . Psychiatric Genetics vol. 5 , ( 4 ) 177 - 180 .

Kalsi G, Curtis D, Brynjolfsson J, Butler R, Sharma T, Murphy P, Read T, Petursson H et al. ( 1995 ) . Investigation by linkage analysis of the XY pseudoautosomal region in the genetic susceptibility to schizophrenia . British Journal of Psychiatry vol. 167 , ( SEPT. ) 390 - 393 .

Lin M-W, Curtis D, Williams N, Arranz M, Nanko S, Collier D, McGuffin P, Murray R et al. ( 1995 ) . Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32 . Psychiatric Genetics vol. 5 , ( 3 ) 117 - 126 .

Sherrington R, Curtis D, Brynjolfsson J, Moloney E, Rifkin L, Petursson H, Gurling H ( 1994 ) . A linkage study of affective disorder with DNA markers for the ABO-AK1-ORM linkage group near the dopamine beta hydroxylase gene . Biological Psychiatry vol. 36 , ( 7 ) 434 - 442 .

Kalsi G, Mankoo BS, Brynjolfsson J, Curtis D, Read T, Murphy P, Sharma T, Petursson H et al. ( 1994 ) . The Marfan syndrome gene locus as a favoured locus for susceptibility to schizophrenia . Psychiatric Genetics vol. 4 , ( 4 ) 219 - 228 .

Curtis D, Brynjolfsson J, Petursson H, Holmes DS, Sherrington R, Brett P, Rifkin L, Murphy P et al. ( 1993 ) . Corrigenda: Segregation and linkage analysis in five manic depression pedigrees excludes the 5HT1a receptor gene (HTR1A) (Annals of Human Genetics (1993) 57 (27-39)) . Annals of Human Genetics vol. 57 , ( 4 )

Sherrington R, Mankoo B, Attwood J, Kalsi G, Curtis D, Buetow K, Povey S, Gurling H ( 1993 ) . Cloning of the Human Dopamine D5 Receptor Gene and Identification of a Highly Polymorphic Microsatellite for the DRD5 Locus That Shows Tight Linkage to the Chromosome 4p Reference Marker RAF1P1 . Genomics vol. 18 , ( 2 ) 423 - 425 .

Curtis D, Sherrington R, Brett P, Holmes DS, Kalsi G, Brynjolfsson J, Petursson H, Rifkin L et al. ( 1993 ) . Genetic linkage analysis of manic depression in Iceland . Journal of the Royal Society of Medicine vol. 86 , ( 9 ) 506 - 510 .

Whitehouse WP, Rees M, Curtis D, Sundqvist A, Parker K, Chung E, Baralle D, Gardiner RM ( 1993 ) . Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region . American Journal of Human Genetics vol. 53 , ( 3 ) 652 - 662 .

Brett P, Robertson M, Gurling H, Curtis D ( 1993 ) . Failure to find linkage and increased homozygosity for the dopamine D3 receptor gene in Tourette's syndrome . The Lancet vol. 341 , ( 8854 )

Sherrington R, Kalsi G, Mankoo BS, Brynjolfsson J, Curtis D, Moloney E, Rifkin L, Petursson H et al. ( 1993 ) . A linkage study with the D5 dopamine receptor in Icelandic pedigrees with multiple cases of manic depression . Psychiatric Genetics vol. 3 , ( 4 ) 241 - 246 .

KALSI G, SHERRINGTON R, MANKOO B, CURTIS D, MELMER G, BRYNJOLFSSON J, SHARMA T, SIGMUNDSSON T et al. ( 1993 ) . GENOMIC CLONING, LOCALIZATION AND IDENTIFICATION OF A HIGHLY POLYMOROHIC MICROSATELLITE SEQUENCE FOR THE D5-DOPAMINE NEURORECEOTOR GENE LOCUS (DRD5) ON CHROMOSOME-4P WHICH SHOWS NO LINKAGE TO SCHIZOPHRENIA, MANIC-DEPRESSION AND TOURETTE SYNDROME . AMERICAN JOURNAL OF HUMAN GENETICS . vol. 53 , 1698 - 1698 .

Bateman JB, Kojis TL, Cantor RM, Heinzmann C, Ngo JT, Spence MA, Inana G, Kivlin JD et al. ( 1993 ) . Linkage analysis of Norrie disease with an X-chromosomal ornithine aminotransferase locus . The Transactions of the American Ophthalmological Society . vol. 91 , 299 - 307 .

CURTIS D, BRYNJOLFSSON J, PETURSSON H, HOLMES DS, SHERRINGTON R, BRETT P, RIFKIN L, MURPHY P et al. ( 1993 ) . SEGREGATION AND LINKAGE ANALYSIS IN 5 MANIC-DEPRESSION PEDIGREES EXCLUDES THE 5HT1A RECEPTOR GENE (HTR1A) (VOL 57, PG 27, 1993) . ANNALS OF HUMAN GENETICS vol. 57 , 311 - 311 .

Hatcher S ( 1992 ) . Postviral fatigue syndrome . The BMJ vol. 304 , ( 6841 )

Melmer G, Sherrington R, Mankoo B, Kalsi G, Curtis D, Gurling HMD ( 1991 ) . A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to DNA loci D5S6, D5S39, and D5S76 . Genomics vol. 11 , ( 3 ) 767 - 769 .

Sherrington R, Melmer G, Dixon M, Curtis D, Mankoo B, Kalsi G, Gurling H ( 1991 ) . Linkage disequilibrium between two highly polymorphic microsatellites . American Journal of Human Genetics vol. 49 , ( 5 ) 966 - 971 .

Mankoo BS, Sherrington R, De La Concha A, Kalsi G, Curtis D, Melmer G, Gurling HMD ( 1991 ) . Two microsatellite polymorphisms at the D5S39 locus . Nucleic Acids Research vol. 19 , ( 8 ) 1963 - 1963 .

Brett P, Schneiden V, Jackson G, Curtis D, Gourdie A, Robertson M, Gurling H ( 1991 ) . Chromosome markers in Tourette's syndrome . The Lancet vol. 337 , ( 8734 ) 184 - 185 .

Brett P, Curtis D, Melmer G, Sherrington R, Holmes D, Robertson M, Gurling H ( 1991 ) . Lindage analysis in a large pedigree multiply affected with gilles de la tourette syndrome . Psychiatric Genetics vol. 1 , ( 2 ) 26 - 28 .

Holmes D, Brynjolfsson J, Brett P, Curtis D, Petursson H, Sherrington R, Gurling H ( 1991 ) . No evidence for a susceptibility locus predisposing to manic depression in the region of the dopamine (D2) receptor gene . British Journal of Psychiatry vol. 158 , ( MAY ) 635 - 641 .

Brett P, Curtis D, Gourdie A, Schnieden V, Jackson G, Holmes D, Robertson M, Gurling H ( 1990 ) . Possible linkage of Tourette syndrome to markers on short arm of chromosome 3 (C3p21-14) . The Lancet vol. 336 , ( 8722 )

Coleman RM, Curtis D ( 1989 ) . Risk behaviours for HIV infection . The BMJ vol. 298 , ( 6686 )

Gurling HMD, Sherrington RP, Brynjolfsson J, Read T, Curtis D, Mankoo BJ, Potter M, Petursson H ( 1989 ) . Recent and Future Molecular Genetic Research Into Schizophrenia . Schizophrenia Bulletin vol. 15 , ( 3 ) 373 - 382 .

Curtis D ( 1985 ) . Recurrent pyoderma in a family with a defect in leucocyte locomotion . The BMJ vol. 290 , ( 6467 )