Publications: Prof Qingzhong Xiao

Sun X, Wu J, Zhang X, Xie C, Wei H, Li P, Yang Y, Yuan H et al. ( 2024 ) . Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats . Hypertension

Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q et al. ( 2023 ) . Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and transdifferentiation of vascular smooth muscle cells to foam cells . Advanced Science

Liu S, Fang C, Zhong C, Li J, Xiao Q ( 2023 ) . Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity . Cell Biology and Toxicology vol. 39 , ( 6 ) 2527 - 2549 .

Yang M, Zhou X, Pearce SWA, Yang Z, Chen Q, Niu K, Liu C, Luo J et al. ( 2023 ) . Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice . Arteriosclerosis Thrombosis and Vascular Biology vol. 43 , ( 10 ) 1900 - 1920 .

Sun X, Lu Y, Wu J, Wen Q, Li Z, Tang Y, Shi Y, He T et al. ( 2023 ) . Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease . Arteriosclerosis Thrombosis and Vascular Biology vol. 43 , ( 10 ) 1867 - 1886 .

Liu S-S, Maguire EM, Bai Y-S, Huang L, Liu Y, Xu L, Fauzi I, Zhang S-Q et al. ( 2023 ) . A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties . Molecular and Cellular Biology vol. 39 , ( 4 ) e00357 - e00318 .

Swiatlowska P, Sit B, Feng Z, Zhou X, Xiao Q, Shanahan C, Yu C, Iskratsch T ( 2023 ) . Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching . MOLECULAR BIOLOGY OF THE CELL . vol. 34 , 740 - 741 .

Sellahewa SG, Li JY, Xiao Q ( 2022 ) . Updated Perspectives on Direct Vascular Cellular Reprogramming and Their Potential Applications in Tissue Engineered Vascular Grafts . Journal of Functional Biomaterials vol. 14 , ( 1 )

Meng X, Wu T, Lou Q, Niu K, Jiang L, Xiao Q, Xu T, Zhang L ( 2022 ) . Optimization of CRISPR–Cas system for clinical cancer therapy . Bioengineering & Translational Medicine vol. 8 , ( 2 )

Efovi D, Xiao Q ( 2022 ) . Noncoding RNAs in Vascular Cell Biology and Restenosis . Biology vol. 12 , ( 1 )

Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, Hu Y, Hu X et al. ( 2022 ) . The Effect of Lymphangiogenesis in Transplant Arteriosclerosis . Circulation vol. 147 , ( 6 ) 482 - 497 .

Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H et al. ( 2022 ) . Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis . Journal of Molecular and Cellular Cardiology vol. 173 , 41 - 42 .

Karamanavi E, McVey DG, van der Laan SW, Stanczyk PJ, Morris GE, Wang Y, Yang W, Chan K et al. ( 2022 ) . The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis . Circulation Research vol. 131 , ( 12 ) 1004 - 1017 .

Zhang C, Niu K, Ren M, Zhou X, Yang Z, Yang M, Wang X, Luo J et al. ( 2022 ) . Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model . Cells vol. 11 , ( 20 )

Zhou K, Chen H, Wang X-Y, Xu Y-M, Liao Y-F, Qin Y-Y, Ge X-W, Zhang T-T et al. ( 2022 ) . Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury . Biomedicine & Pharmacotherapy vol. 155 ,

Yang S, Wang C, Ruan C, Chen M, Cao R, Sheng L, Chang N, Xu T et al. ( 2022 ) . Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction . Cells vol. 11 , ( 10 )

Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al. ( 2022 ) . Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching . Science Advances

Yan Y, Xu Y, Yang X, Li Z, Niu K, Liu C, Zhao M, Xiao Q et al. ( 2022 ) . Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption . Oxidative Medicine and Cellular Longevity vol. 2022 ,

Pan M, Cheng Z-W, Huang C-G, Ye Z-Q, Sun L-J, Chen H, Fu B-B, Zhou K et al. ( 2022 ) . Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts . Ecotoxicology and Environmental Safety vol. 234 ,

Yao L, Hao Y, Wen G, Xiao Q, Wu P, Wang J, Liu J ( 2022 ) . Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice . Frontiers in Pharmacology vol. 13 ,

Yang M, Chen Q, Mei L, Wen G, An W, Zhou X, Niu K, Liu C et al. ( 2021 ) . Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling . British Journal of Pharmacology vol. 178 , ( 20 ) 4048 - 4068 .

Zhang C, Niu K, Lian P, Hu Y, Shuai Z, Gao S, Ge S, Xu T et al. ( 2021 ) . Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases . Hypertension (Dallas, Tex. : 1979) vol. 78 , ( 1 ) 16 - 29 .

Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS et al. ( 2021 ) . Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation . Molecular Medicine Reports vol. 23 , ( 5 )

An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K et al. ( 2021 ) . Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling . Cardiovascular Research vol. 118 , ( 2 ) 638 - 653 .

Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al. ( 2020 ) . Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching .

Chen D, Zhang C, Chen J, Yang M, Afzal TA, An W, Maguire EM, He S et al. ( 2020 ) . miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts . The Journal of Pathology vol. 253 , ( 2 ) 209 - 224 .

He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W et al. ( 2020 ) . miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia . Stem Cell Research & Therapy vol. 11 , ( 1 )

Liu C, Niu K, Xiao Q ( 2020 ) . Updated Perspectives On Vascular Cell Specification And Pluripotent Stem Cell-Derived Vascular Organoids For Studying Vasculopathies . Cardiovascular Research

Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y et al. ( 2020 ) . Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis . Circulation Research

Maguire EM, Xiao Q ( 2020 ) . Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia . The FEBS Journal vol. 287 , ( 24 ) 5260 - 5283 .

Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR et al. ( 2020 ) . Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis . Atherosclerosis vol. 296 , 11 - 17 .

Maguire EM, Pearce SWA, Xiao R, Oo AY, Xiao Q ( 2019 ) . Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection . Pharmaceuticals vol. 12 , ( 3 )

Pearce S, Xiao Q, Wu W, An W, Yang M ( 2019 ) . BS38 Role of neutrophil elastase in abdominal aortic aneurysms and thoracic aortic dissection . Heart . Conference: Basic Science vol. 105 ,

Yang F, Chen Q, Yang M, Maguire EM, Yu X, He S, Xiao R, Wang CS et al. ( 2019 ) . Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia . Cardiovasc Res

Maguire EM, Pearce SWA, Xiao Q ( 2018 ) . Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease . Vascular Pharmacology vol. 112 , 54 - 71 .

Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P et al. ( 2018 ) . Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation . Nature Communications vol. 9 , ( 1 )

Xiao Q ( 2018 ) . 119 Macrophage-derived MMP-8 determines vascular smooth muscle cell differentiation from adventitia stem cells and promotes neointima hyperplasia . Heart . Conference: Basic Science vol. 104 ,

Xiao Q, He S ( 2018 ) . 139 Microrna-214 is a novel player in inflammatory smooth muscle cell differentiation and angioplasty restenosis . Heart . Conference: Basic Science vol. 104 ,

Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M et al. ( 2018 ) . Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis . J Am Heart Assoc vol. 7 , ( 4 )

Yang F, Chen Q, He S, Yang M, Maguire EM, An W, Afzal TA, Luong LA et al. ( 2017 ) . miR-22 Is a Novel Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation and Neointima Formation . Circulation vol. 137 , ( 17 ) 1824 - 1841 .

Zhang C, Chen D, Margaret Maguire E, He S, Chen J, An W, Yang M, Adeel Afzal T et al. ( 2017 ) . Cbx3 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration and Neointima Formation . Cardiovascular Research

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R et al. ( 2017 ) . The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle . Human Molecular Genetics vol. 27 , ( 1 ) 199 - 210 .

Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G et al. ( 2017 ) . Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia . Arterioscler Thromb Vasc Biol vol. 37 , ( 11 ) 2182 - 2194 .

Maguire EM, Xiao Q, Xu Q ( 2017 ) . Differentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells . Arteriosclerosis Thrombosis and Vascular Biology vol. 37 , ( 11 ) 2026 - 2037 .

Xiao Q ( 2017 ) . A novel pathological role of hnRNPA1 in vascular smooth muscle cell functions and neointima hyperplasia . Atherosclerosis . vol. 263 ,

Chen Q, Wang Q, Zhu J, Xiao Q, Zhang L ( 2017 ) . Reactive oxygen species: key regulators in vascular health and diseases . British Journal of Pharmacology vol. 175 , ( 8 ) 1279 - 1292 .

AHLUWALIA A ( 2017 ) . The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque . Proceedings of the National Academy of Sciences of USA

Xiao Q ( 2017 ) . Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Prevents Experimental Atherosclerosis by Inhibiting Foam Cell Formation . JOURNAL OF VASCULAR RESEARCH . vol. 54 , 9 - 9 .

Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E et al. ( 2016 ) . NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia . Journal of the American Heart Association vol. 5 , ( 12 ) e004629 - e004629 .

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2016 ) . [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II . vol. 34 , is. &NA; , Wolters Kluwer

Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R et al. ( 2016 ) . Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction . PLoS Genetics vol. 12 , ( 7 ) e1006127 - e1006127 .

Afzal TA, Xiao Q ( 2016 ) . 173 Functional Role of microRNA-214 in Modulating Vascular Smooth Muscle Cell Functions and Neointima Formation . Heart . vol. 102 ,

Weiwei A, Xiao Q ( 2016 ) . 174 hnRNPA1 is A Critical Regulator in Vascular Smooth Muscle Cell Functions and Neointima Hyperplasia . Heart . vol. 102 ,

Yang F, Xiao Q ( 2016 ) . 197 miRNA-22 Regulates Vascular Smooth Muscle Cell Functions and Prevents Neointima Formation by Targeting EVI-1 . Heart . vol. 102 ,

Yang F, Chen Q, Wen G, Zhang C, Luong LA, Zhu J, Zhang L, Xiao Q ( 2016 ) . Functional role of miRNA-34A in smooth muscle cell functions and neointima formation . Atherosclerosis vol. 244 , e3 - e4 .

Chen Q, Yang F, Guo M, Wen G, Zhang C, Luong LA, Zhu J, Xiao Q et al. ( 2015 ) . miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration . Journal of Molecular and Cellular Cardiology vol. 89 , ( Pt A ) 75 - 86 .

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II . Hypertension vol. 66 , ( suppl_1 )

Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X et al. ( 2015 ) . XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling . Arteriosclerosis Thrombosis and Vascular Biology vol. 35 , ( 10 ) 2134 - 2144 .

Zhao H, Wen G, Huang Y, Yu X, Chen Q, Luong L, Zhu J, Ye S et al. ( 2015 ) . Methyl CPG binding protein 2 inhibition by microRNA-22 is required for stem cell differentiation towards smooth muscle cells . Atherosclerosis . vol. 241 , e18 - e19 .

Wen G, Chen Q, Luong L, Mustafa A, Ye S, Xiao Q ( 2015 ) . Unexpected role of matrix metalloproteinase-8 (MMP8) in macrophage polarization . Atherosclerosis . vol. 241 ,

Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J et al. ( 2015 ) . Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells . Cell Death and Differentiation vol. 22 , ( 7 ) 1170 - 1180 .

Wen G, Zhang C, Chen Q, Luong LA, Mustafa A, Ye S, Xiao Q ( 2015 ) . A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization* . Journal of Biological Chemistry vol. 290 , ( 31 ) 19158 - 19172 .

Xiao Q, Chen Q, Yang F ( 2015 ) . 211 Mirna-34a Reduces Neointima fommation through Inhibiting Smooth Muscle Cell Proliferation and Migration . Heart . vol. 101 ,

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . PP.LB03.07 . Journal of Hypertension . vol. 33 , e518 - e519 .

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S et al. ( 2015 ) . Blood-pressure associated variants in <i>NPR3</i> affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II . vol. 29 , is. 10 , pp. 624 - 624 .

Chen Q, Wen G, Huang Y, Luong L, Zhu J, Zhang L, Xiao Q ( 2015 ) . Hnrnpa1 is a critical regulator in vascular smooth muscle cell functions and neointima hyperplasia . EUROPEAN HEART JOURNAL . vol. 36 , 1025 - 1025 .

Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J et al. ( 2015 ) . MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG-Binding Protein 2 . ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY vol. 35 , ( 4 ) 918 - 929 .

Wen G, Chen Q, Le Anh Luong, Mustafa A, Shu Y, Xiao Q ( 2014 ) . Matrix metalloproteinase-8 (MMP8) modulates M2 macrophage polarization and molecular mechanisms involved . Atherosclerosis vol. 237 , ( 2 )

Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Le Anh Luong, Zhu J et al. ( 2014 ) . MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG binding protein 2 . Atherosclerosis vol. 237 , ( 2 )

Zhao H, Huang Y, Yu X, Wen G, Ye S, Zhang L, Xiao Q ( 2014 ) . MICRORNA-22 REGULATES SMOOTH MUSCLE CELL DIFFERENTIATION FROM STEM CELLS BY TARGETING METHYL CPG BINDING PROTEIN 2 . ATHEROSCLEROSIS . vol. 235 , E130 - E131 .

Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M et al. ( 2014 ) . Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation . Arterioscler Thromb Vasc Biol vol. 34 , ( 1 ) 90 - 98 .

Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z et al. ( 2013 ) . Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2 . J Biol Chem vol. 288 , ( 44 ) 31853 - 31866 .

Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W, Xiao Q ( 2013 ) . MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1 . Stem Cells vol. 31 , ( 9 ) 1749 - 1762 .

Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S, Xiao Q ( 2013 ) . Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2 . Circulation Research vol. 113 , ( suppl_1 )

Chen Q, Jin M, Yang F, Zhu J, Xiao Q, Zhang L ( 2013 ) . Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling . Mediators of Inflammation vol. 2013 ,

Fang C, Wen G, Zhang L, Lin L, Moore A, Wu S, Ye S, Xiao Q ( 2013 ) . An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo . Cardiovasc Res vol. 99 , ( 1 ) 146 - 155 .

Huang Y, Lin L, Yu X, Wen G, Pu X, Zhao H, Fang C, Zhu J et al. ( 2013 ) . Functional involvements of heterogeneous nuclear ribonucleoprotein A1 in smooth muscle differentiation from stem cells in vitro and in vivo . Stem Cells vol. 31 , ( 5 ) 906 - 917 .

Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J et al. ( 2013 ) . Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis . Circulation vol. 127 , ( 16 ) 1712 - 1722 .

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant . American Journal of Human Genetics vol. 92 , ( 3 ) 366 - 374 .

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant . Am J Hum Genet vol. 92 , ( 3 ) 366 - 374 .

Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q et al. ( 2013 ) . XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation . Journal of Biological Chemistry vol. 288 , ( 2 ) 859 - 872 .

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D et al. ( 2013 ) . Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions . Circ Res vol. 112 , ( 1 ) 35 - 47 .

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C et al. ( 2013 ) . ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT . HEART . vol. 99 , A5 - U20 .

Zheng X, Wu Y, Zhu L, Chen Q, Zhou Y, Yan H, Chen T, Xiao Q et al. ( 2013 ) . Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB . Differentiation vol. 85 , ( 1-2 ) 41 - 54 .

Chen Q, Jin M, Zhu J, Xiao Q, Zhang L ( 2013 ) . Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation . BIOMED RESEARCH INTERNATIONAL vol. 2013 , Article ARTN 623978 ,

Yu X, Zhang L, Wen G, Zhao H, Huang Y, Zhu J, Xu Q, Ye S et al. ( 2013 ) . MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells . CIRCULATION . vol. 128 ,

Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S, Xiao Q ( 2013 ) . Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2 . CIRCULATION RESEARCH . vol. 113 ,

Zhou Y, Yan H, Guo M, Zhu J, Xiao Q, Zhang L ( 2013 ) . Reactive Oxygen Species in Vascular Formation and Development . OXIDATIVE MEDICINE AND CELLULAR LONGEVITY vol. 2013 , Article ARTN 374963 ,

Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C et al. ( 2013 ) . Tetrahydrobiopterin Determines Vascular Remodeling Through Enhanced Endothelial Cell Survival and Regeneration . CIRCULATION . vol. 128 , S50 - S58 .

Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F et al. ( 2012 ) . Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells . Hum Mol Genet vol. 21 , ( 18 ) 4021 - 4029 .

Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y et al. ( 2012 ) . Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model . American Journal of Pathology vol. 181 , ( 1 ) 362 - 373 .

Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y et al. ( 2012 ) . Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells . Arteriosclerosis, Thrombosis, and Vascular Biology vol. 32 , ( 3 ) 730 - 744 .

Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y et al. ( 2012 ) . Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells . Arterioscler Thromb Vasc Biol vol. 32 , ( 3 ) 730 - 744 .

Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ, Ye S ( 2012 ) . Influence of matrix metalloproteinase-12 on fibrinogen level . Atherosclerosis vol. 220 , ( 2 ) 351 - 354 .

Wang G, Xiao Q, Luo Z, Ye S, Xu Q ( 2012 ) . Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis . J Biol Chem. vol. 287 , ( 4 ) Article 9505 , 2896 - 2906 .

Wang G, Xiao Q, Luo Z, Ye S, Xu Q ( 2012 ) . Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis . J Biol Chem vol. 287 , ( 4 ) 2896 - 2906 .

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D et al. ( 2012 ) . A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions . CIRCULATION vol. 126 , ( 21 )

Liang Q-L, Liang X-P, Wang Y-M, Xie Y-Y, Zhang R-L, Chen X, Gao R, Cheng Y-J et al. ( 2012 ) . Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode . JOURNAL OF TRANSLATIONAL MEDICINE vol. 10 , Article ARTN 26 ,

Huang Y, Lin L, Yu X, Pu X, Zhu J, Zhang L, Ye S, Xiao Q ( 2012 ) . Functional Involvements of Heterogeneous Nuclear Ribonucleoprotein A1 in Smooth Muscle Differentiation from Stem Cells in vitro and in vivo . CIRCULATION vol. 126 , ( 21 )

Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M et al. ( 2012 ) . Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation . CIRCULATION vol. 126 , ( 21 )

Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q, Xiao Q ( 2012 ) . Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi . CIRCULATION vol. 126 , ( 21 )

Zhang L, Zheng X, Wu Y, Chen Q, Zhu J, Xiao Q ( 2012 ) . Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by 'Targeting Sirtnin 1 . CIRCULATION vol. 126 , ( 21 )

Knoflach M, Kiechl S, Mantovani A, Cuccovillo I, Bottazzi B, Xu Q, Xiao Q, Gasperi A et al. ( 2012 ) . Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies . PLOS ONE vol. 7 , ( 2 ) Article ARTN e31474 ,

Zeng L, Xiao Q, Li H, Margariti A, Hu Y, Xu Q ( 2012 ) . XBP1 regulates endothelial growth and angiogenesis in ischemic tissues . VASCULAR PHARMACOLOGY . vol. 56 , 309 - 309 .

Sims D, Xiao Q ( 2011 ) . Smooth Muscle Cell Differentiation from Embryonic Stem Cells: Role of HDAC7 and PDGF-BB . Stem Cells and Cancer Stem Cells, Volume 4 , Springer Nature

Kiechl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC et al. ( 2011 ) . Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis . Circ Cardiovasc Genet vol. 4 , ( 6 ) 681 - 686 .

Zhou B, Margariti A, Zeng L, Habi O, Xiao Q, Martin D, Wang G, Hu Y et al. ( 2011 ) . Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation . Arterioscler Thromb Vasc Biol vol. 31 , ( 11 ) 2676 - 2684 .

Xiao Q, Pepe A, Wang G, Luo Z, Zeng L, Ye S, Xu Q ( 2011 ) . 51 PLA2g7 mediates smooth muscle cell differentiation from stem cells . Heart . vol. 97 ,

Luo Z, Xiao Q, Wang W, Xu Q ( 2011 ) . DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS . HEART vol. 97 , ( 20 ) 4 - 4 .

Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S et al. ( 2011 ) . Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis . Arterioscler Thromb Vasc Biol vol. 31 , ( 8 ) 1842 - 1852 .

Kane NM, Xiao Q, Baker AH, Luo Z, Xu Q, Emanueli C ( 2011 ) . Pluripotent Stem Cell Differentiation into Vascular Cells: A Novel Technology with Promises for Vascular Re(Generation) . Pharmacol Ther. vol. 129 , ( 1 ) 29 - 49 .

Wang G, Xiao Q, Xu Q ( 2011 ) . STEM CELL DIFFERENTIATION TO SMOOTH MUSCLE CELLS IS REGULATED BY HNRNP A2/B1 . HEART vol. 97 , ( 20 ) 3 - 4 .

Luo ZL, Wang G, Wang W, Xiao QZ, Xu QB ( 2011 ) . Signalling pathways that regulate endothelial differentiation from stem cells . FRONT BIOSCI-LANDMRK vol. 16 , 472 - 485 .

Xiao Q, Ye S ( 2011 ) . The genetics of epigenetics: is there a link with cardiovascular disease . Heart vol. 97 , ( 2 ) 96 - 97 .

Zhang L, Jin M, Margariti A, Wang G, Luo Z, Zampetaki A, Zeng L, Ye S et al. ( 2010 ) . Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells . J Biol Chem vol. 285 , ( 49 ) 38463 - 38472 .

Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A et al. ( 2010 ) . Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis . Arterioscler Thromb Vasc Biol vol. 30 , ( 12 ) 2678 - 2683 .

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