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Research
  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Rathithevy Gangeswaran

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Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2022 ) . Modification of the Early Gene Enhancer-promoter Improves the Oncolytic Potency of Adenovirus 11 . Molecular Therapy vol. 31 , ( 1 )
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B et al. ( 2022 ) . ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning . Development vol. 149 , ( 13 )
Baleeiro RB, Bouwens CJ, Liu P, Di Gioia C, Dunmall LSC, Nagano A, Gangeswaran R, Chelala C et al. ( 2022 ) . MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy . OncoImmunology vol. 11 , ( 1 )
Marelli G, Dunmall LSC, Yuan M, Di Gioia C, Miao J, Cheng Z, Zhang Z, Liu P et al. ( 2021 ) . A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer . Journal for ImmunoTherapy of Cancer vol. 9 , ( 1 )
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al. ( 2020 ) . Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus . Molecular Therapy vol. 28 , ( 5 ) 1263 - 1275 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2017 ) . Correction for Spurrell et al., “STAT1 Interaction with E3-14.7K in Monocytes Affects the Efficacy of Oncolytic Adenovirus” . Journal of Virology vol. 91 , ( 20 ) 10.1128/jvi.00670 - 10.1128/jvi.00617 .
Spurrell E, Gangeswaran R, Wang P, Cao F, Gao D, Feng B, Wold W, Tollefson A et al. ( 2014 ) . STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus . J Virol vol. 88 , ( 4 ) 2291 - 2300 .
Hiley CT, Chard LS, Gangeswaran R, Tysome JR, Briat A, Lemoine NR, Wang Y ( 2013 ) . Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway . J Virol vol. 87 , ( 5 ) 2781 - 2790 .
Tysome JR, Li X, Wang S, Wang P, Gao D, Du P, Chen D, Gangeswaran R et al. ( 2012 ) . A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity . Clin Cancer Res vol. 18 , ( 24 ) 6679 - 6689 .
Wong HH, Jiang G, Gangeswaran R, Wang P, Wang J, Yuan M, Wang H, Bhakta V et al. ( 2012 ) . Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11 . Mol Ther vol. 20 , ( 2 ) 306 - 316 .
Tysome JR, Wang P, Alusi G, Briat A, Gangeswaran R, Wang J, Bhakta V, Fodor I et al. ( 2011 ) . Lister vaccine strain of vaccinia virus armed with the endostatin-angiostatin fusion gene: an oncolytic virus superior to dl1520 (ONYX-015) for human head and neck cancer . Hum Gene Ther vol. 22 , ( 9 ) 1101 - 1108 .
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP et al. ( 2009 ) . CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells . J Clin Invest vol. 119 , ( 6 ) 1604 - 1615 .
Tysome JR, Briat A, Hiley C, Gangeswaran R, Chikkanna-Gowda CP, Bhakta V, Alusi G, Trivedi K et al. ( 2009 ) . Systemic Delivery of Lister Strain Vaccinia Virus to Tumors Is Facilitated by the Depletion of Macrophages in Immuno-Competent Mice . MOLECULAR THERAPY . vol. 17 , S247 - S247 .
( 2009 ) . BSGT 2009 Oral Presentations . Human Gene Therapy . vol. 20 , 389 - 395 .
Wong HH, Gangeswaran R, Francis J, Lemoine NR, Wang Y ( 2009 ) . Adenovirus 11 is an Alternative Oncolytic Virus Targeting Adenovirus 5-Insensitive Cancer and Shows Distinct E1A Gene Transcriptional Activity . MOLECULAR THERAPY . vol. 17 , S235 - S236 .
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C et al. ( 2008 ) . Yes-associated protein (YAP) functions as a tumor suppressor in breast . Cell Death Differ vol. 15 , ( 11 ) 1752 - 1759 .
Lopes RB, Gangeswaran R, McNeish IA, Wang Y, Lemoine NR ( 2007 ) . Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy . Int J Cancer vol. 120 , ( 11 ) 2344 - 2352 .
Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H et al. ( 2007 ) . Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway . Oncogene vol. 26 , ( 14 ) 2082 - 2094 .
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2007 ) . Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . Oncogene vol. 26 , ( 11 ) 1533 - 1545 .
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC et al. ( 2007 ) . Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation . Br J Cancer vol. 96 , ( 2 ) 373 - 382 .
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T ( 2006 ) . Sperm associated antigen 1 (spag1) is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells . PANCREAS vol. 33 , ( 4 ) 485 - 486 .
Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W et al. ( 2005 ) . Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma . Gastroenterology vol. 129 , ( 5 ) 1454 - 1463 .
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Lüttges J et al. ( 2005 ) . Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer . Am J Pathol vol. 166 , ( 1 ) 81 - 92 .
Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos JP et al. ( 2003 ) . Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent . J Pathol vol. 201 , ( 1 ) 63 - 74 .
Santibáñez Koref MF, Gangeswaran R, Santibáñez Koref IP, Shanahan N, Hancock JM ( 2003 ) . A phylogenetic approach to assessing the significance of missense mutations in disease genes . Hum Mutat vol. 22 , ( 1 ) 51 - 58 .
LEMOINE N, Crnogorac-Jurcevic T, Costello E, Jones M, Blaveri E, Missaglia E, Neoptolemos JP, Gangeswaran R et al. ( 2003 ) . Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent . J. Pathol. vol. 201 , 63 - 74 .
Santibáñez-Koref MF, Gangeswaran R, Hancock JM ( 2001 ) . A relationship between lengths of microsatellites and nearby substitution rates in mammalian genomes . Mol Biol Evol vol. 18 , ( 11 ) 2119 - 2123 .
Santibanez MF, Gangeswaran R, Hancock JM ( 1999 ) . CA repeat stimulated recombination: The role of mismatch repair in an E-coli model . AM J HUM GENET vol. 65 , ( 4 ) A320 - A320 .
Parrington J, Brind S, De Smedt H, Gangeswaran R, Lai FA, Wojcikiewicz R, Carroll J ( 1998 ) . Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization . Dev Biol vol. 203 , ( 2 ) 451 - 461 .
Gangeswaran R, Jones KT ( 1997 ) . Unique protein kinase C profile in mouse oocytes: lack of calcium-dependent conventional isoforms suggested by rtPCR and Western blotting . FEBS Lett vol. 412 , ( 2 ) 309 - 312 .
Gangeswaran R, Eady RR ( 1996 ) . Flavodoxin 1 of Azotobacter vinelandii: characterization and role in electron donation to purified assimilatory nitrate reductase . Biochem J vol. 317 ( Pt 1) , ( Pt 1 ) 103 - 108 .
Gangeswaran R, Lowe DJ, Eady RR ( 1993 ) . Purification and characterization of the assimilatory nitrate reductase of Azotobacter vinelandii . Biochem J vol. 289 ( Pt 2) , ( Pt 2 ) 335 - 342 .
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