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  1. Queen Mary University of London
  2. Research
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Publications: Dr Judith Offman

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Srinivasan S, Kryza T, Bock N, Tse BWC, Sokolowski KA, Janaththani P, Fernando A, Moya L et al. ( 2024 ) . A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer . Nature Communications vol. 15 , ( 1 )
Bancroft EK, Page EC, Brook MN, Pope J, Thomas S, Myhill K, Helfand BT, Talaty P et al. ( 2024 ) . The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers . BJU International vol. 134 , ( 3 ) 484 - 500 .
Tan WK, Maroni R, Offman J, Zamani SA, Team BT, di Pietro M, O’Donovan M, Muldrew B et al. ( 2024 ) . Targeted Screening for Barrett’s Esophagus and Esophageal Cancer: Post Hoc Analysis From the Randomized BEST3 Trial . Gastroenterology vol. 167 , ( 4 ) 798 - 800.e4 .
Tan WK, Maroni R, Offman J, Zamani S, Di Pietro M, O'Donovan M, Sasieni P, Fitzgerald RC ( 2024 ) . 861 MODELLING FROM A MULTICENTRE, PRAGMATIC, RANDOMISED CONTROLLED TRIAL IDENTIFIES THE TARGET SCREENING POPULATION AND EXPECTED YIELD FOR BARRETT'S ESOPHAGUS AND ESOPHAGEAL CANCER DIAGNOSES . Gastroenterology vol. 166 , ( 5 ) s - 196 .
Hill H, Kearns B, Pashayan N, Roadevin C, Sasieni P, Offman J, Duffy S ( 2023 ) . The cost-effectiveness of risk-stratified breast cancer screening in the UK . British Journal of Cancer . vol. 129 , 1801 - 1809 .
Rumgay H, Cabasag CJ, Offman J, de Camargo Cancela M, Barchuk A, Mathur P, Wang S, Wei W et al. ( 2023 ) . International burden of cancer deaths and years of life lost from cancer attributable to four major risk factors: a population-based study in Brazil, Russia, India, China, South Africa, the United Kingdom, and United States . EClinicalMedicine vol. 66 ,
Eastwood M, Sailem H, Marc ST, Gao X, Offman J, Karteris E, Fernandez AM, Jonigk D et al. ( 2023 ) . MesoGraph: Automatic profiling of mesothelioma subtypes from histological images . Cell Reports Medicine vol. 4 , ( 10 )
Ahmad AS, Offman J, Delon C, North BV, Shelton J, Sasieni PD ( 2023 ) . Years of life lost due to cancer in the United Kingdom from 1988 to 2017 . British Journal of Cancer vol. 129 , ( 10 ) 1558 - 1568 .
Dibden A, Offman J, Duffy SW, Gabe R ( 2023 ) . Reply to Yaffe, M.J. Correction for Self-Selection in Breast Cancer Screening. Comment on “Dibden et al. Worldwide Review and Meta-Analysis of Cohort Studies Measuring the Effect of Mammography Screening Programmes on Incidence-Based Breast Cancer Mortality. Cancers 2020, 12, 976” . Cancers vol. 15 , ( 18 )
Eastwood M, Marc ST, Gao X, Sailem H, Offman J, Karteris E, Fernandez AM, Jonigk D et al. ( 2023 ) . Malignant Mesothelioma subtyping via sampling driven multiple instance prediction on tissue image and cell morphology data . Artificial Intelligence in Medicine vol. 143 ,
Ghimire B, Landy R, Maroni R, Smith SG, Debiram-Beecham I, Sasieni PD, Fitzgerald RC, Rubin G et al. ( 2023 ) . Patient reported experiences of the Cytosponge test: Analysis of patient survey data from the BEST3 trial .
Ghimire B, Landy R, Maroni R, Smith SG, Debiram-Beecham I, Sasieni PD, Fitzgerald RC, Rubin G et al. ( 2023 ) . Predictors of the experience of a Cytosponge test: analysis of patient survey data from the BEST3 trial . BMC Gastroenterology vol. 23 , ( 1 )
Eastwood M, Marc ST, Gao X, Sailem H, Offman J, Fernandez AM, Jonigk D, Cookson W et al. ( 2022 ) . EP07.03-005 MesoGraph: Graph Neural Networks for Weakly Supervised Cellular Profiling in the Subtyping of Malignant Mesothelioma Images . Journal of Thoracic Oncology vol. 17 , ( 9 ) s331 - s332 .
Eastwood M, Marc ST, Gao X, Sailem H, Offman J, Karteris E, Fernandez AM, Jonigk D et al. ( 2022 ) . Malignant Mesothelioma Subtyping of Tissue Images via Sampling Driven Multiple Instance Prediction . Artificial Intelligence in Medicine , vol. 13263 , Springer Nature
Keith Tan W, Maroni R, Offman J, Pietro MD, Honing J, O’Donovan M, Sasieni P, Fitzgerald R ( 2022 ) . O6 Ideal age to screen for Barrett’s oesophagus and oesophageal adenocarcinoma: modelling from the cytosponge-BEST3 trial . Conference: Oral presentationsa3.2 - a3a4 .
Maroni R, Barnes J, Offman J, Scheibl F, Smith SG, Debiram-Beecham I, Waller J, Sasieni P et al. ( 2022 ) . Patient-reported experiences and views on the Cytosponge test: a mixed-methods analysis from the BEST3 trial . BMJ Open vol. 12 , ( 4 )
Eastwood M, Marc ST, Gao X, Sailem H, Offman J, Fernandez AM, Jonigk D, Cookson W et al. ( 2022 ) . MesoGraph: Graph Neural Networks for Weakly Supervised Cellular Profiling in the Subtyping of Malignant Mesothelioma Images . JOURNAL OF THORACIC ONCOLOGY . vol. 17 , S331 - S332 .
Offman J, Pesola F, Fitzgerald RC, Hamilton W, Sasieni P ( 2021 ) . Impact of Barrett oesophagus diagnoses and endoscopies on oesophageal cancer survival in the UK: A cohort study . Cancer Medicine vol. 11 , ( 4 ) 1160 - 1171 .
Bancroft EK, Page EC, Brook MN, Thomas S, Taylor N, Pope J, McHugh J, Jones A-B et al. ( 2021 ) . A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study . The Lancet Oncology vol. 22 , ( 11 ) 1618 - 1631 .
Raghallaigh HN, Brook MN, Saunders EJ, Kumar P, Hazell S, Sohaib A, Dias A, Mcgrowder E et al. ( 2021 ) . P0992 The PROFILE study. Targeted screening using germline genetics in men with a family history of prostate cancer . European Urology vol. 79 ,
Ni RH, Brook MN, Saunders EJ, Kumar P, Hazell S, Sohaib A, Dias A, Mcgrowder E et al. ( 2021 ) . The PROFILE study. Targeted screening using germline genetics in men with a family history of prostate cancer . EUROPEAN UROLOGY . vol. 79 , S1395 - S1395 .
Fitzgerald RC, di Pietro M, O'Donovan M, Maroni R, Muldrew B, Debiram-Beecham I, Gehrung M, Offman J et al. ( 2020 ) . Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial . The Lancet vol. 396 , ( 10247 ) 333 - 344 .
Fitzgerald RC, Di Pietro M, O'Donovan M, Muldrew B, Debiram-Beecham I, Offman J, Baseley L, Smith SG et al. ( 2020 ) . 634 RESULTS FROM THE BARRETT'S OESOPHAGUS TRIAL 3 (BEST3): A RANDOMISED CONTROLLED TRIAL COMPARING THE CYTOSPONGE™-TFF3 TEST WITH USUAL CARE TO IDENTIFY OESOPHAGEAL PRECANCER IN PRIMARY CARE PATIENTS WITH CHRONIC GASTROESOPHAGEAL REFLUX . Gastroenterology vol. 158 , ( 6 ) s - 136 .
Dibden A, Offman J, Duffy SW, Gabe R ( 2020 ) . Worldwide review and meta-analysis of cohort studies measuring the effect of mammography screening programmes on incidence-based breast cancer mortality . Cancers vol. 12 , ( 4 )
Fitzgerald RC, Di Pietro M, O'Donovan M, Muldrew B, Debiram-Beecham I, Offman J, Baseley L, Smith SG et al. ( 2020 ) . RESULTS FROM THE BARRETT'S OESOPHAGUS TRIAL 3 (BEST3): A RANDOMISED CONTROLLED TRIAL COMPARING THE CYTOSPONGE™-FF3 TEST WITH USUAL CARE TO IDENTIFY OESOPHAGEAL PRE-CANCER IN PRIMARY CARE PATIENTS WITH CHRONIC GASTROESOPHAGEAL REFLUX . GASTROENTEROLOGY . vol. 158 , S136 - S136 .
Page EC, Bancroft EK, Brook MN, Assel M, Al Battat MH, Thomas S, Taylor N, Chamberlain A et al. ( 2019 ) . Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers . European Urology vol. 76 , ( 6 ) 831 - 842 .
Page E, Bancroft E, Brook M, Assel M, Offman J, Kote-Jarai Z, Vickers A, Lilja H et al. ( 2019 ) . Interim results from the IMPACT study: evidence for PSA screening in <i>BRCA2</i> mutation carriers . BRITISH JOURNAL OF CANCER . vol. 121 , 13 - 13 .
Offman J, Muldrew B, O’Donovan M, Debiram-Beecham I, Pesola F, Kaimi I, Smith SG, Wilson A et al. ( 2018 ) . Barrett’s oESophagus trial 3 (BEST3): study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux . BMC Cancer vol. 18 , ( 1 )
Bancroft EK, Saya S, Page EC, Myhill K, Thomas S, Pope J, Chamberlain A, Hart R et al. ( 2018 ) . Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations . BJU International vol. 123 , ( 2 ) 284 - 292 .
Wilson A, -Beecham ID, Bowers B, Muldrew B, Aigret B, O'Donovan M, Tripathi M, Offman J et al. ( 2018 ) . Sa1643 - Feasibility of the Implementation of Cytosponge as a Triage Test for Reflux Symptoms in Primary Care: Barrett's Esophagus Screening Trial 3 (Best3) . Gastroenterology vol. 154 , ( 6 ) s - 339 .
OFFMAN JM, PESOLA F, SASIENI P ( 2018 ) . Trends and projections in adenocarcinoma and squamous cell carcinoma of the oesophagus in England from 1971 to 2037 . British Journal of Cancer
Wilson A, Debiram-Beecham I, Bowers B, Muldrew B, Aigret B, O'Donovan M, Tripathi M, Offman J et al. ( 2018 ) . FEASIBILITY OF THE IMPLEMENTATION OF CYTOSPONGE AS A TRIAGE TEST FOR REFLUX SYMPTOMS IN PRIMARY CARE: BARRETT'S ESOPHAGUS SCREENING TRIAL 3 (BEST3) . GASTROENTEROLOGY . vol. 154 , S339 - S339 .
Allgood, MARONI R, Hudson S, Offman, Turnbull AE, Peacock L, Steel J, Kirby G et al. ( 2017 ) . The effect of second timed appointments for non-attenders of breast cancer screening in England: a randomised controlled trial . Lancet Oncology
Offman J, Fitzgerald RC ( 2017 ) . Alternatives to Traditional Per-Oral Endoscopy for Screening . Gastrointestinal Endoscopy Clinics of North America vol. 27 , ( 3 ) 379 - 396 .
Freeman M, OFFMAN JM, Walter FM, Sasieni P, Smith SG ( 2017 ) . Acceptability of the Cytosponge procedure for detecting Barrett's oesophagus: a qualitative study . BMJ Open vol. 7 ,
Offman J, Pesola F, Fitzgerald R, Hamilton W, Sasieni P ( 2016 ) . Incidence and progression of Barrett's oesophagus in clinical practice: A cohort analysis for planning of the Barrett's ESophagus Trial 3 (BEST3) comparing the Cytosponge-TFF3 test with usual care . European Journal of Surgical Oncology vol. 42 , ( 11 ) s252 - s253 .
Sheringham J, Sequeira R, Myles J, Hamilton W, McDonnell J, Offman J, Duffy S, Raine R ( 2016 ) . Variations in GPs' decisions to investigate suspected lung cancer: a factorial experiment using multimedia vignettes . BMJ Quality & Safety vol. 26 , ( 6 )
Allgood PC, Maxwell AJ, Hudson S, Offman J, Hutchison G, Beattie C, Tuano-Donnelly R, Threlfall A et al. ( 2016 ) . A randomised trial of the effect of postal reminders on attendance for breast screening . British Journal of Cancer vol. 114 , ( 2 ) 171 - 176 .
Duffy SW, Dibden A, Michalopoulos D, Offman J, Parmar D, Jenkins J, Collins B, Robson T et al. ( 2015 ) . Screen detection of ductal carcinoma in situ and subsequent incidence of invasive interval breast cancers: a retrospective population-based study . The Lancet Oncology vol. 17 , ( 1 ) 109 - 114 .
Gallina I, Colding C, Henriksen P, Beli P, Nakamura K, Offman J, Mathiasen DP, Silva S et al. ( 2015 ) . Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control . Nature Communications vol. 6 , ( 1 )
Gallina I, Colding CS, Henriksen P, Beli P, Nakamura K, Offman J, Mathiasen DP, Silva S et al. ( 2015 ) . Regulation of homologous recombination . YEAST . vol. 32 , S32 - S32 .
Offman J, Sasieni P ( 2015 ) . Trends in adenocarcinoma and squamous cell carcinoma of the oesophagus in England: 1970s to 2012 . EUROPEAN JOURNAL OF CANCER CARE vol. 24 , 13 - 13 .
Offman J, Myles J, Ariyanayagam S, Colorado Z, Sharp M, Cruice M, North BV, Shiel S et al. ( 2014 ) . A telephone reminder intervention to improve breast screening information and access . Public Health vol. 128 , ( 11 ) 1017 - 1022 .
Offman J, Myles J, Ariyanayagam S, Colorado Z, Sharp M, Cruice M, North BV, Shiel S et al. ( 2014 ) . A telephone reminder intervention to improve breast screening information and access . Public Health vol. 128 , ( 11 ) 1017 - 1022 .
Dibden A, Offman J, Parmar D, Jenkins J, Slater J, Binysh K, McSorley J, Scorfield S et al. ( 2013 ) . Reduction in interval cancer rates following the introduction of two-view mammography in the UK breast screening programme . British Journal of Cancer vol. 110 , ( 3 ) 560 - 564 .
Offman J, Wilson M, Lamont M, Birke H, Kutt E, Marriage S, Loughrey Y, Hudson S et al. ( 2013 ) . A randomised trial of weekend and evening breast screening appointments . British Journal of Cancer vol. 109 , ( 3 ) 597 - 602 .
Offman J ( 2013 ) . Confronting Hereditary Breast and Ovarian Cancer: Identify Your Risk, Understand Your Options, Change Your Destiny . BMJ Sexual & Reproductive Health vol. 39 , ( 1 )
Tabar L, Lindhe N, Yen AMF, Chen THH, Chiu SYH, Fann JCY, Chen SLS, Wu GHM et al. ( 2012 ) . Radiotherapy After Surgery for Small Breast Cancers of Stellate Appearance . Imaging of the Breast - Technical Aspects and Clinical Implication , IntechOpen
Wong CS, Lim GH, Gao F, Jakes RW, Offman J, Chia KS, Duffy SW ( 2011 ) . Mammographic density and its interaction with other breast cancer risk factors in an Asian population . British Journal of Cancer vol. 104 , ( 5 ) 871 - 874 .
Duffy SW, Mackay J, Thomas S, Anderson E, Evans DG, Fielder H, Fox R, Gray J et al. ( 2010 ) . Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study . LANCET ONCOL vol. 11 , ( 12 ) 1127 - 1134 .
Clyne M, Offman J, Shanley S, Virgo JD, Radulovic M, Wang Y, Ardern-Jones A, Eeles R et al. ( 2009 ) . The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome . British Journal of Cancer vol. 100 , ( 2 ) 376 - 380 .
Offman J, Jina N, Theron T, Pallas J, Hubank M, Lehmann A ( 2008 ) . Transcriptional changes in trichothiodystrophy cells . DNA Repair vol. 7 , ( 8 ) 1364 - 1371 .
Botta E, Offman J, Nardo T, Ricotti R, Zambruno G, Sansone D, Balestri P, Raams A et al. ( 2006 ) . Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype–phenotype relationships . Human Mutation vol. 28 , ( 1 ) 92 - 96 .
Offman J, Gascoigne K, Bristow F, Macpherson P, Bignami M, Casorelli I, Leone G, Pagano L et al. ( 2005 ) . Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome . Molecular Cancer Research vol. 3 , ( 5 ) 251 - 260 .
Offman J, Opelz G, Doehler B, Cummins D, Halil O, Banner NR, Burke MM, Sullivan D et al. ( 2004 ) . Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation . Blood vol. 104 , ( 3 ) 822 - 828 .
Karran P, Offman J, Bignami M ( 2003 ) . Human mismatch repair, drug-induced DNA damage, and secondary cancer . Biochimie vol. 85 , ( 11 ) 1149 - 1160 .
Casorelli I, Offman J, Mele L, Pagano L, Sica S, D’Errico M, Giannini G, Leone G et al. ( 2003 ) . Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome . DNA Repair vol. 2 , ( 5 ) 547 - 559 .
Massey A, Offman J, Macpherson P, Karran P ( 2003 ) . DNA mismatch repair and acquired cisplatin resistance in E. coli and human ovarian carcinoma cells . DNA Repair vol. 2 , ( 1 ) 73 - 89 .
Casorelli I, Offman J, Mele L, Pagano L, Sica S, Leone G, Karran P, Bignami M ( 2001 ) . Mismatch repair defects among italian cases of secondary acute leukemia and myelodysplastic syndrome . European Journal of Cancer vol. 37 ,
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