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Research

Publications: Dr Alistair Symonds

Symonds ALJ, Busharat Z, Du M, Miao T, Li S, Hou X, Wang P ( 2024 ) . Memory Phenotype Tfh Cells Develop Without Overt Infection and Support Germinal Center Formation and B Cell Responses to Viral Infection . European Journal of Immunology
Wang X, Zha H, Wu W, Yuan T, Xie S, Jin Z, Long H, Yang F et al. ( 2023 ) . CD200+ cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti–PD-1/PD-L1 therapy . Science Translational Medicine vol. 15 , ( 679 )
Symonds ALJ, Miao T, Busharat Z, Li S, Wang P ( 2022 ) . Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells . Cancer Immunology, Immunotherapy vol. 72 , ( 5 ) 1139 - 1151 .
Symonds AL, Zheng W, Miao T, Wang H, Wang T, Kiome R, Hou X, Li S et al. ( 2020 ) . Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells . Life Science Alliance vol. 3 , ( 9 )
Zhou J, Huang S, Wang Z, Huang J, Xu L, Tang X, Wan YY, Li Q-J et al. ( 2019 ) . Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation . Nature Communications vol. 10 , ( 1 )
Zhao L, He R, Long H, Guo B, Jia Q, Qin D, Liu S-Q, Wang Z et al. ( 2018 ) . Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells . Nature Medicine vol. 24 , ( 10 ) 1536 - 1544 .
Omodho B, Miao T, Symonds ALJ, Singh R, Li S, Wang P ( 2018 ) . Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells . Immunity Inflammation and Disease vol. 6 , ( 2 ) 221 - 233 .
Singh R, Miao T, Symonds ALJ, Omodho B, Li S, Wang P ( 2017 ) . Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells . J Immunol vol. 198 , ( 11 ) 4394 - 4402 .
Ogbe A, Miao T, Symonds ALJ, Omodho B, Singh R, Bhullar P, Li S, Wang P ( 2015 ) . Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells* . Journal of Biological Chemistry vol. 290 , ( 33 ) 20455 - 20465 .
Li S, Symonds ALJ, Miao T, Sanderson I, Wang P ( 2014 ) . Modulation of Antigen-Specific T-Cells as Immune Therapy for Chronic Infectious Diseases and Cancer . Frontiers in Immunology vol. 5 ,
Miao T, Raymond M, Bhullar P, Ghaffari E, Symonds ALJ, Meier UC, Giovannoni G, Li S et al. ( 2013 ) . Early growth response gene-2 controls IL-17 expression and Th17 differentiation by negatively regulating Batf . J Immunol vol. 190 , ( 1 ) 58 - 65 .
Li S, Miao T, Sebastian M, Bhullar P, Ghaffari E, Liu M, Symonds ALJ, Wang P ( 2012 ) . The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells . Immunity vol. 37 , ( 4 ) 685 - 696 .
Liu M, Miao T, Zhu H, Symonds ALJ, Li L, Schurich A, Maini MK, Zhang J et al. ( 2012 ) . IL-2-Engineered nano-APC Effectively Activates Viral Antigen-Mediated T Cell Responses from Chronic Hepatitis B Virus-Infected Patients . JOURNAL OF IMMUNOLOGY vol. 188 , ( 3 ) 1534 - 1543 .
Li SL, Symonds ALJ, Zhu B, Liu MY, Raymond MV, Miao TZ, Wang P ( 2011 ) . Early Growth Response Gene-2 (Egr-2) Regulates the Development of B and T Cells . PLOS ONE vol. 6 , ( 4 ) Article e18498 ,
Zhu B, Symonds ALJ, Martin JE, Kioussis D, Wraith DC, Li SL, Wang P ( 2008 ) . Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease . J EXP MED vol. 205 , ( 10 ) 2295 - 2307 .
WANG P, odriguez-Cabezas ME, Li S, Sundstedt A, Nicolson K, Khalid S, Symonds A, Minaee S et al. ( 2006 ) . Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance . Eur J Immunol. vol. 36 , 1374 - 1385 .
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