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Research

Publications: Dr Upkar Gill

Gill US, McCarthy NE ( 2019 ) . CD4 T cells in hepatitis B virus: "You don't have to be cytotoxic to work here and help" . Journal of Hepatology
Gill US, Golden-Mason L ( 2019 ) . HCMV jogs the ‘memory’ of NK cells in HBV . Journal of Hepatology vol. 70 , ( 3 ) 343 - 345 .
Schurich A, Pallett LJ, Jajbhay D, Wijngaarden J, Otano I, GIll US, Hansi N, Kennedy PT et al. ( 2016 ) . Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host . Cell Reports vol. 16 , ( 5 ) 1243 - 1252 .
Stegmann KA, Robertson F, Hansi N, Gill U, Pallant C, Christophides T, Pallett LJ, Peppa D et al. ( 2016 ) . CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver . Scientific Reports vol. 6 , 26157 - 26157 .
Rivino L, Van Den Berg M, Gill, Le Bert N, Koh S, Hansi N, Newell E, Foster G et al. ( 2015 ) . PTU-103 Characterisation of the immune profile in chronic hepatitis b patients following nucleos(t)ide discontinuation by cytof mass cytometry . Gut . vol. 64 ,
Hansi N, Gill, Banerjee M, Naik S, Tong W, Foster G, Carey I, Kennedy P ( 2015 ) . PTU-106 Identifying true immune-tolerant disease in children and young adults with chb using quantified hepatitis b surface antigen levels . Gut . vol. 64 ,
Hansi N, Gill, Banerjee M, Naik S, Tong W, Foster G, Carey I, Kennedy P ( 2015 ) . PTU-107 Defining the low-risk inactive carrier in chronic hepatitis b with qhbsag: do the same rules apply in children and young adults? . Gut . vol. 64 ,
Gill, Peppa D, Micco L, Singh H, Foster G, Maini M, Kennedy P ( 2015 ) . PTU-116 Functional immune restoration correlates with HBSAG decline and may predict treatment response on sequential NUC therapy in CHB . Gut . vol. 64 ,
Gill, Hansi N, Payaniandy L, Schulz J, Payaniandy D, Alazawi W, Dearden J, Kallis Y et al. ( 2015 ) . PTU-117 Sequential NUC therapy following pegylated interferon provides a greater decline in HBSAG and potentially offers a treatment advantage over current therapies . Gut . vol. 64 ,
KENNEDY PATRICK ( 2015 ) . Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells . Nature Medicine vol. 21 , 591 - 600 .
Rivino L, Van Den Berg M, Le Bert N, Koh S, Gill US, Hansi NK, Foster GR, Bertoletti A et al. ( 2015 ) . P0474 : Characterisation of the immune profiles of chronic hepatitis B patients following NUC discontinuation by cyTOF mass cytometry . Journal of Hepatology . vol. 62 ,
Huang W-C, Peppa D, Easom N, Tang X-Z, Singh H, Fusai G, Rosenberg W, Ghosh I et al. ( 2015 ) . P0478 : NKG2D-dependent cross-talk between NK cells and CD4 T cells in chronic hepatitis B . Journal of Hepatology . vol. 62 ,
Gill US, Peppa D, Micco L, Singh HD, Foster GR, Maini MK, Kennedy PT ( 2015 ) . P0485 : Functional immune restoration correlates with HBsAg decline and may predict treatment response on sequential NUC therapy in chronic hepatitis B . Journal of Hepatology . vol. 62 ,
Pallett L, Gill U, Jover-Cobos M, Schurich A, Singh K, Thomas N, Das A, Chen A et al. ( 2014 ) . Arginase-dependent metabolic regulation of hepatic immunopathology by myeloid-derived suppressor cells . IMMUNOLOGY vol. 143 , 154 - 154 .
GILL US, Zissimopoulos A, Al-Shamma S, Burke K, McPhail MJ, Barr DA, Yallis YN, Marley RT et al. ( 2014 ) . Assessment of bone mineral density in tenofovir-treated patients with chronic hepatitis B: can the fracture risk assessment tool identify those at greatest risk? . The Journal of Infectious Diseases vol. 211 , ( 3 ) 374 - 382 .
Kennedy PTF, Gill US, Bertoletti A, Mason WS ( 2014 ) . O106 CLONAL HEPATOCYTE REPOPULATION IN THE YOUNG ADULT HBV INFECTED LIVER CHALLENGES THE CONCEPT OF A GENERIC IMMUNE TOLERANT DISEASE PHASE . Journal of Hepatology . vol. 60 ,
Pallett LJ, Haniffa M, Schurich A, Gill U, Davies N, Jover-Cobos M, Das A, Gilson R et al. ( 2014 ) . P132 MYELOID-DERIVED SUPPRESSOR CELLS MEDIATE IMMUNOTOLERANCE IN CHRONIC HEPATITIS B (CHB) THROUGH ARGININE DEPRIVATION . Journal of Hepatology . vol. 60 ,
Huang W-C, Peppa D, Easom N, Tan X-Z, Chang C, Trowsdale J, Gill U, Kennedy P et al. ( 2014 ) . P137 THE EXPRESSION OF NKG2D-LIGANDS BY ACTIVATED CD4 T CELLS RENDERS THEM SUSCEPTIBLE TO NK CELL REGULATION IN CHRONIC HEPATITIS B (CHB) . Journal of Hepatology . vol. 60 ,
Gill US, Peppa D, Micco L, Singh HD, Foster GR, Maini MK, Kennedy PTF ( 2014 ) . P152 SEQUENTIAL NUC THERAPY FOLLOWING PEGYLATED INTERFERON-ALPHA EXPOSURE RESTORES INNATE IMMUNE RESPONSES CONFERRING A TREATMENT ADVANTAGE OVER NUC MONOTHERAPY IN CHRONIC HEPATITIS B . Journal of Hepatology . vol. 60 ,
Lubowiecki M, Pallmer K, Jajbhay D, Pallett LJ, Gill U, Kennedy PT, Maini M, Schurich A ( 2014 ) . P159 CO-INHIBITORY RECEPTOR LAG-3 POSITIVE CD8 T CELLS PRODUCE IMMUNOSUPPRESSIVE TGF-β IN CHRONIC HBV . Journal of Hepatology . vol. 60 , s118 - s119 .
Vergis N, Khamri W, Atkinson S, Tidswell R, Gill U, Ryan J, Bernsmeier C, Triantafyllou E et al. ( 2014 ) . P306 MONOCYTE OXIDATIVE BURST DEFECT PREDICTS RISK OF INFECTION IN ALCOHOLIC HEPATITIS . Journal of Hepatology . vol. 60 ,
Gill US, Peppa D, Singh HD, Micco L, Foster GR, Maini MK, Kennedy PT ( 2014 ) . Functional innate immune responses are restored with sequential NUC therapy following Pegylated Interferon-Alpha exposure and not with NUC monotherapy in Chronic Hepatitis B . HEPATOLOGY . vol. 60 , 1020A - 1021A .
Hansi NK, Gill US, Banerjee A, Surendraraj N, Patel C, Naik S, Foster GR, Kennedy PT ( 2014 ) . High levels of Hepatitis B surface antigen (HBsAg) can exclude significant fibrosis and distinguishes true 'immune-tolerance' in children and young adults with Chronic Hepatitis B . HEPATOLOGY . vol. 60 , 985A - 986A .
Jo J, Tan AT, Ussher JE, Sandalova E, Tang XZ, Tan-Garcia A, To N, Hong M et al. ( 2014 ) . Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver . PLoS Pathogens vol. 10 , ( 6 )
Lubowiecki M, Pallmer K, Jajbhay D, Pallett LJ, Gill U, Kennedy PT, Maini MK, Schurich A ( 2013 ) . Co-inhibitory receptor LAG-3 positive CD8 T cells produce immunosuppressive TGF-beta in chronic HBV . IMMUNOLOGY . vol. 140 , 145 - 145 .
Pallett LJ, Haniffa M, Jover-Cobos M, Schurich A, Das A, Gill U, Davies N, Ghosh I et al. ( 2013 ) . Expansion of arginase-expressing myeloid-derived suppressor cells in hepatotropic viral infections . IMMUNOLOGY . vol. 140 , 97 - 97 .
Gill US, Zissimopoulos A, Al-shamma S, Burke K, McPhail M, Barr D, Ross V, Kallis Y et al. ( 2013 ) . FRAX SCORE IN THE ASSESSMENT OF BONE MINERAL DENSITY CHANGES IN TENOFOVIR TREATED CHRONIC HEPATITIS B PATIENTS . GUT . vol. 62 , A190 - A190 .
Gill US, Payaniandy L, Schulz J, Payaniandy D, Ross V, Kallis Y, Kooner P, Marley R et al. ( 2013 ) . SEQUENTIAL ORAL ANTI-VIRAL THERAPY FOLLOWING PEGYLATED-INTERFERON-ALPHA FAILURE SIGNIFICANTLY INCREASES HBSAG DECLINE . GUT . vol. 62 , A189 - A190 .
Schurich A, Pallett LJ, Lubowiecki M, Singh HD, Gill US, Kennedy PT, Nastouli E, Tanwar S et al. ( 2013 ) . The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells . PLoS Pathogens vol. 9 , ( 3 )
Gill US, Payaniandy L, Payaniandy D, Schulz J, Ross VA, Kallis YN, Kooner P, Marley RTC et al. ( 2013 ) . INDUCTION MAINTENANCE THERAPY IN CHRONIC HEPATITIS B; STEP-DOWN FROM COMBINATION LAMIVUDINE AND TENOFOVIR TO LAMIVUDINE MONOTHERAPY - A POTENTIAL NEW TREATMENT STRATEGY . JOURNAL OF HEPATOLOGY . vol. 58 , S302 - S302 .
Chen A, Schurich A, Aleong J-AC, Trivedi K, Gill U, Peppa D, Kennedy P, Bertoletti A et al. ( 2013 ) . PROBING HEPATIC ANTIGEN PRESENTATION IN PATIENTS WITH CHRONIC HBV INFECTION . JOURNAL OF HEPATOLOGY . vol. 58 , S136 - S136 .
Peppa D, Gil US, Reynolds G, Easom NJW, Pallett LJ, Schurich A, Micco L, Nebbia G et al. ( 2013 ) . Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion . Journal of Experimental Medicine vol. 210 , ( 1 ) 99 - 114 .
Das A, Ellis G, Pallant C, Lopes AR, Khanna P, Peppa D, Chen A, Blair P et al. ( 2012 ) . IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection . JOURNAL OF IMMUNOLOGY vol. 189 , ( 8 ) 3925 - 3935 .
Patel C, Gill U, Alazawi W, Shaw P, Alstead EM, Kallis Y, Kooner P, Marley R et al. ( 2012 ) . Benchmarking disease activity and progression in Chronic Hepatitis B infected young adults . HEPATOLOGY . vol. 56 , 362A - 362A .
Gill U, Zissimopoulos A, Al-Shamma S, Burke KB, Ross VA, Kallis Y, Kooner P, Marley R et al. ( 2012 ) . FRAX score in the assessment of Bone Mineral Density changes in Tenofovir treated Chronic Hepatitis B patients: comparison with bone biochemistry and DEXA scanning . HEPATOLOGY . vol. 56 , 201A - 201A .
Kennedy PTF, Sandalova E, Jo J, Gill U, Ushiro-Lumb I, Tan AT, Naik S, Foster GR et al. ( 2012 ) . Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B . Gastroenterology vol. 143 , ( 3 ) 637 - 645 .
Gill US, Payaniandy L, Schulz J, Ross V, Kallis Y, Kooner P, Marley R, Ushiro-Lumb I et al. ( 2012 ) . CAN A 3-MONTH "STOPPING RULE" FOR PEGYLATED-INTERFERON-alpha BE APPLIED TO A UK POPULATION OF CHRONIC HEPATITIS B INFECTED PATIENTS OF MIXED GENOTYPE? . GUT vol. 61 , A145 - A145 .
Patel C, Gill US, Alazawi W, Shaw P, Alstead E, Kallis Y, Kooner P, Marley R et al. ( 2012 ) . EVALUATION OF LIVER FIBROSIS IN YOUNG ADULT PATIENTS WITH CHRONIC HEPATITIS B VIRUS . GUT vol. 61 , A133 - A133 .
Gill US, Payaniandy L, Payaniandy D, Schulz J, Ross V, Kallis Y, Kooner P, Marley R et al. ( 2012 ) . INDUCTION MAINTENANCE TREATMENT IN CHRONIC HEPATITIS B; STEP-DOWN FROM TENOFOVIR AND LAMIVUDINE TO LAMIVUDINE MONOTHERAPY IS EFFECTIVE . GUT vol. 61 , A145 - A145 .
Gill US, Papadaki M, Peppa D, Micco L, Li L, Ushiro-Lumb I, Foster GR, Maini MK et al. ( 2012 ) . MAXIMAL BOOSTING OF INNATE IMMUNITY DURING PEGYLATED INTERFERON-alpha THERAPY IS REACHED AT 48 WEEKS IN E-ANTIGEN POSITIVE CHRONIC HEPATITIS B . GUT vol. 61 , A145 - A146 .
Gill US, Papadaki M, Peppa D, Micco L, Li L, Ushiro-Lumb I, Foster GR, Maini MK et al. ( 2012 ) . MAXIMAL BOOSTING OF INNATE IMMUNITY DURING PEGYLATED INTERFERON-APLHA THERAPY IS REACHED AT 48 WEEKS IN E-ANTIGEN POSITIVE CHRONIC HEPATITIS B . JOURNAL OF HEPATOLOGY . vol. 56 , S175 - S175 .
Peppa D, Gill U, Micco L, Schurich A, Nebbia G, Singh H, Rosenberg W, Gilson R et al. ( 2011 ) . Susceptibility of T cells to death ligand-mediated deletion in the liver of chronic hepatitis B virus (CHB) infected patients . IMMUNOLOGY . vol. 135 , 60 - 60 .
Gill U, Al-Shamma S, Burke KB, Ross VA, Marley R, Kooner P, Foster GR, Kennedy PT ( 2011 ) . BONE MINERAL DENSITY LOSS IN TENOFOVIR TREATED CHRONIC HEPATITIS B VIRUS (HBV) PATIENTS IS A CONSEQUENCE OF VITAMIN D DEFICIENCY AND NOT TENOFOVIR THERAPY . HEPATOLOGY . vol. 54 , 1012A - 1012A .
Kennedy PT, Sandalova E, Jo J, Gill U, Li L, Ushiro-Lumb I, Naik S, Foster GR et al. ( 2011 ) . IMMUNOLOGICAL ANALYSIS AND CLINICAL PROFILE OF CHRONIC HEPATITIS B VIRUS (HBV) INFECTION IN THE YOUNGER PATIENT . HEPATOLOGY . vol. 54 , 1092A - 1093A .
Gill US, Al-shamma S, Burke K, Ross V, Marley RTC, Kooner P, Foster GR, Kennedy PTF ( 2011 ) . P61 Bone mineral density loss in tenofovir treated Chronic Hepatitis B Virus (HBV) patients is a consequence of Vitamin D deficiency and not Tenofovir therapy . Gut vol. 60 , ( Suppl 2 )
Kennedy PTF, Sandalova E, Jo J, Gill US, Li L, Ushiro-Lumb I, Naik S, Foster GR et al. ( 2011 ) . P62 Immunological analysis and clinical profile of Chronic Hepatitis B Virus (HBV) infection in the younger patient . Gut vol. 60 , ( Suppl 2 )
Patel C, Gill US, Glyn F, Naik S, Foster GR, Kennedy PTF ( 2011 ) . CHRONIC HBV INFECTION: ASSESSMENT AND MANAGEMENT OF DISEASE IN A YOUNG ADULT CLINIC . GUT . vol. 60 ,
Glyn F, Gill US, Alazawi W, Ross V, Kooner P, Marley R, Foster GR, Kennedy PTF ( 2011 ) . EFFICACY OF COMBINATION TENOFOVIR PLUS LAMIVUDINE VERSUS TENOFOVIR MONOTHERAPY IN PATIENTS WITH CHRONIC HEPATITIS B VIRUS . GUT . vol. 60 , A231 - A231 .
Gill US, Al-Shamma S, Burke K, Ross V, Marley R, Kooner P, Foster GR, Kennedy PTF ( 2011 ) . FACTORS DETERMINING BONE MINERAL DENSITY LOSS IN CHRONIC HEPATITIS B PATIENTS: IS TENOFOVIR DISOPROXIL FUMARATE THE MAIN CULPRIT? . GUT . vol. 60 ,
Gill U, Micco L, Li L, Peppa D, Ushiro-Lumb I, Foster GR, Maini MK, Kennedy PTF ( 2011 ) . PEGYLATED INTERFERON A MODULATES INNATE IMMUNITY IN EAG POSITIVE CHRONIC HEPATITIS B AND DETERMINES CHANGES IN HBSAG QUANTIFICATION . GUT . vol. 60 , A232 - A232 .
Gunawan A, Gill US, Glyn F, Kooner P, Marley R, Ushiro-Lumb I, Foster GR, Kennedy PTF ( 2011 ) . UTILITY OF HBSAG QUANTIFICATION IN DEVELOPING AN INDIVIDUALISED APPROACH TO THE MANAGEMENT OF CHRONIC HEPATITIS B VIRUS IN CLINICAL PRACTICE . GUT . vol. 60 ,
Gill US, Al-Shamma S, Burke K, Ross V, Kooner P, Marley R, Foster GR, Kennedy PTF ( 2011 ) . FACTORS DETERMINING BONE MINERAL DENSITY LOSS IN CHRONIC HEPATITIS B PATIENTS: IS TENOFOVIR DISOPROXIL FUMARATE THE MAIN CULPRIT? . JOURNAL OF HEPATOLOGY . vol. 54 , S286 - S286 .
Gill US, Micco L, Li L, Peppa D, Ushiro-Lumb I, Foster GR, Maini MK, Kennedy PTF ( 2011 ) . PEGYLATED INTERFERON ALPHA MODULATES INNATE IMMUNITY IN EAG POSITIVE CHRONIC HEPATITIS B AND DETERMINES CHANGES IN HBSAG QUANTIFICATION . JOURNAL OF HEPATOLOGY . vol. 54 , S32 - S32 .