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Research

Publications: Dr Moheyeldin Elshikh

El Shikh MEM, El Sayed R, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ et al. ( 2022 ) . Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis . Front Med (Lausanne) vol. 9 ,
Elsayed R, Kurago Z, Cutler CW, Arce RM, Gerber J, Celis E, Sultan H, Elashiry M et al. ( 2020 ) . Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw . FASEB Journal vol. 34 , ( 2 ) 2595 - 2608 .
El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ et al. ( 2019 ) . Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis . Journal of Autoimmunity
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM et al. ( 2018 ) . Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production . Annals of the Rheumatic Diseases vol. 77 , ( 12 ) 1773 - 1781 .
Elsayed R, Celis E, Sultan H, Cutler C, Elashiry M, Meghil M, Kurago Z, Awad M et al. ( 2018 ) . Impaired Dendritic Cell Function and Bacterial Load Increase in the Oral Microenvironment as Contributing Factors to the Induction of MRONJ . JOURNAL OF BONE AND MINERAL RESEARCH . vol. 33 , 22 - 22 .
Shikh ME, Sayed RE, Fossati-Jimack L, Pitzalis C ( 2018 ) . O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis . Annals of the Rheumatic Diseases . Conference: Oral presentations vol. 77 ,
Altamimi A-MS, Alafeefy AM, Balode A, Vozny I, Pustenko A, Shikh MEE, Alasmary FAS, Abdel-Gawad SA et al. ( 2017 ) . Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A . Journal of Enzyme Inhibition and Medicinal Chemistry vol. 33 , Article 1 , 147 - 150 .
Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK et al. ( 2017 ) . ADAM10-mediated ICOS ligand shedding on b cells is necessary for proper T Cell ICOS regulation and T follicular helper responses . Journal of Immunology vol. 199 , ( 7 ) 2305 - 2315 .
El Shikh MEM, El Sayed R, Pitzalis C ( 2017 ) . Isolation and Characterization of Mouse and Human Follicular Dendritic Cells . Methods Mol Biol vol. 1623 , 113 - 123 .
Rivellese F, Humby F, Kelly S, Nerviani A, Mauro D, Rocher-Ros V, El Shikh ME, de Paulis A et al. ( 2016 ) . SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS . Presented at: EULAR 2016 ,
Cooley LF, El Shikh ME, Li W, Keim RC, Zhang Z, Strauss JF, Zhang Z, Conrad DH ( 2016 ) . Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice . Sci Rep vol. 6 , 25840 - 25840 .
Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD et al. ( 2016 ) . LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation . J Immunol vol. 196 , ( 5 ) 2085 - 2094 .
Cooley LF, Martin RK, Zellner HB, Irani A-M, Uram-Tuculescu C, El Shikh ME, Conrad DH ( 2015 ) . Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice . PLoS One vol. 10 , ( 5 ) e0124331 - e0124331 .
Shikh MEME ( 2014 ) . SP0011 Follicular Dendritic Cells in Immunity and Autoimmunity . Annals of the Rheumatic Diseases . vol. 73 ,
Al-Mousawi AZ, El Shikh MEM, Pitzalis C ( 2014 ) . IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS . RHEUMATOLOGY . vol. 53 , 84 - 84 .
Folgosa L, Zellner HB, El Shikh ME, Conrad DH ( 2013 ) . Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding . J Immunol vol. 191 , ( 12 ) 5951 - 5958 .
El Shikh ME, Kmieciak M, Manjili MH, Szakal AK, Pitzalis C, Tew JG ( 2013 ) . Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells . Hum Vaccin Immunother vol. 9 , ( 11 ) 2434 - 2444 .
El Shikh ME, Biggioggero M, El Sayed R, Kmieciak M, Manjili M, Szakal A, Meroni PL, Pitzalis C et al. ( 2013 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES vol. 71 , 129 - 129 .
Folgosa L, El Shikh M, Conrad D ( 2013 ) . New implications of ADAMs in TNF{alpha} related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNF{alpha} (P4388) . The Journal of Immunology vol. 190 , ( Meeting Abstracts 1 )
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, DRAKE DIII, MOSQUERA L, LI C, KACHURIN AM et al. ( 2012 ) . Methods of evaluating an immune response to an antigen . no. 13167115 ,
El Shikh MEM, Biggioggero M, El Sayed RM, Kmieciak M, Manjili MH, Szakal AK, Meroni PL, Pitzalis C et al. ( 2012 ) . REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 71 , A38 - A38 .
TEW J, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE DIII, SONG H, WARREN W ( 2012 ) . MODELS FOR VACCINE ASSESSMENT . no. 07872536.3 ,
El Shikh MEM, El Sayed R, Szakal AK, Tew JG, Drake III DR, Wittman V, Eatrides J, Warren WL ( 2012 ) . Rapid generation of T cell-independent antibody responses to T cell-dependent antigens . no. EP20110185845 ,
Tew JG, El Shikh, Mohey, Edin, M., Singh I, Mishkin E, Drake D, Song H, Warren WL ( 2012 ) . Models for vaccine assessment . no. EP20110165211 ,
Tew JG, El Shikh ME, El Sayed RM, Schenkein HA ( 2012 ) . Dendritic cells, antibodies reactive with oxLDL, and inflammation . J Dent Res vol. 91 , ( 1 ) 8 - 16 .
El Shikh MEM, Pitzalis C ( 2012 ) . Follicular dendritic cells in health and disease . Front Immunol vol. 3 ,
SUKUMAR S, EL SHIKH MEM, TEW JG, SANCHEZ-SCHMITZ G, DRAKE, III, Donald, MOSQUERA L, MISHKIN E, KACHURIN AM et al. ( 2011 ) . In vitro germinal centers . no. 11642938 ,
El Shikh ME, El Sayed R, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . RHEUMATOLOGY . vol. 50 , 51 - 51 .
Ciurtin C, Majeed Y, Naylor J, Sukumar P, English A, Emery P, Beech D, Malik N et al. ( 2011 ) . Cell receptor-ligand interaction, signalling, activation and apoptosis21. Pregnenolone Sulphate is Similar to Dexamethasone in Supressing the Unfettered Secretion of Hyaluronan: In Vitro Study on Cultured Synovial Fibroblasts from Patients with Longstanding Rheumatoid Arthritis . Rheumatology vol. 50 , ( suppl_3 ) iii50 - iii52 .
El Shikh ME, El Sayed RM, Kmieciak M, Manjili M, Szakal A, Pitzalis C, Tew J ( 2011 ) . BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS . ANNALS OF THE RHEUMATIC DISEASES . vol. 70 ,
Kikuchi T, El Shikh MM, El Sayed RM, Purkall DB, Elaasser MM, Sarraf A, Barbour SE, Schenkein HA et al. ( 2010 ) . Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells . Journal of Periodontal Research vol. 45 , ( 6 ) 720 - 730 .
Hanaa YA, El Shikh HH, Eglal AG, Ragab AM, Saad AA, Hashem AM, El Sayed RM, El Shikh ME ( 2010 ) . Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs . Current Cancer Therapy Reviews vol. 6 , ( 3 ) 222 - 228 .
El Shikh MEM, El Sayed RM, Sukumar S, Szakal AK, Tew JG ( 2010 ) . Activation of B cells by antigens on follicular dendritic cells . Trends Immunol vol. 31 , ( 6 ) 205 - 211 .
TEW JG, EL SHIKH MEM, SINGH I, MISHKIN E, DRAKE, III, Donald, SONG H, WARREN WL ( 2010 ) . Models for vaccine assessment . no. 11819335 ,
El Shikh ME, El Sayed R, Szakal A, Tew J ( 2010 ) . Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells . The Journal of Immunology vol. 184 , ( Meeting Abstract Supplement )
El Sayed R, El Shikh ME, Schenkein H, Tew J ( 2010 ) . Dominance of macrophage derived IFN-{gamma} in atheromatous lesions . The Journal of Immunology vol. 184 , ( Meeting Abstract Supplement )
Gibb DR, El Shikh M, Kang D, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG et al. ( 2010 ) . ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo . The Journal of Experimental Medicine vol. 207 , ( 3 ) 623 - 635 .
Gibb DR, El Shikh M, Kang D-J, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG et al. ( 2010 ) . ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo . Journal of Cell Biology vol. 188 , ( 4 ) i8 - i8 .
El Shikh ME, Sayed RM, Tew JG, Burton GF ( 2010 ) . Follicular Dendritic Cells (B Lymphocyte Stimulating) . Encyclopedia of Life Sciences, 32 Volume Set , Editors: Ltd, JWS , Wiley
Wu Y, El Shikh MEM, El Sayed RM, Best AM, Szakal AK, Tew JG ( 2009 ) . IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation . Int Immunol vol. 21 , ( 6 ) 745 - 756 .
TEW JG, EL SHIKH, Mohey, Edin, M., SINGH I, MISHKIN E, DRAKE D, SONG H, WARREN WL ( 2009 ) . MODELS FOR VACCINE ASSESSMENT . no. EP20070872536 200706 ,
Gibb DR, El Shikh M, Kang D, El Sayed R, Crawford H, Tew JG, Conrad DH ( 2009 ) . ADAM10 regulates B cell development and immunoglobulin production . The Journal of Immunology vol. 182 , ( 1_MeetingAbstracts )
El Shikh MEM, El Sayed RM, Szakal AK, Tew JG ( 2009 ) . T-independent antibody responses to T-dependent antigens: a novel follicular dendritic cell-dependent activity . J Immunol vol. 182 , ( 6 ) 3482 - 3491 .
Abu Seadah AA, El Shikh ME ( 2008 ) . RAPD typing of Aspergillus chevalieri, Aspergillus nidulans, Aspergillus tetrazonus (quadrilineatus) and their teleomorphs using 5'-d[AACGCGCAAC]-3' and 5'-d[CCCGTCAGCA]-3' primers . Mol Biol Rep vol. 35 , ( 2 ) 89 - 95 .
Shikh MEE, Sayed RE, Szakal AK, Tew JG ( 2008 ) . Conversion of T-dependent (TD) antigens to T-independent (TI) antigens: A novel follicular dendritic cell (FDC)-dependent activity . The FASEB Journal vol. 22 , ( 2_MeetingAbstracts )
John DV, Crisa L, Cauvi G, El Shikh ME, Tew JG, Torbett BE ( 2008 ) . Primary human immune response to dendritic cell inoculation in humanized mice . The FASEB Journal vol. 22 , ( 2_MeetingAbstracts )
Sukumar S, El Shikh ME, Tew JG, Szakal AK ( 2008 ) . Ultrastructural study of highly enriched follicular dendritic cells reveals their morphology and the periodicity of immune complex binding . Cell Tissue Res vol. 332 , ( 1 ) 89 - 99 .
Tew JG, El Shikh MEM, Singh I, Mishkin E, Drake D, Song H, Warren WL ( 2008 ) . Models for vaccine assessment . no. US 11/819,335 ,
Wu YZ, Sukumar S, El Shikh ME, Best AM, Szakal AK, Tew JG ( 2008 ) . Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation . J IMMUNOL vol. 180 , ( 1 ) 281 - 290 .
El Shikh MEM, El Sayed RM, Wu Y, Szakal AK, Tew JG ( 2007 ) . TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity . J Immunol vol. 179 , ( 7 ) 4444 - 4450 .
Sukumar S, El Shikh MEM, Warren WL, Fahlenkamp H, Tew JG, Sanchez-Schmitz G, Drake D, Mosquera L et al. ( 2007 ) . In Vitro germinal centers . no. US 11/642,938 ,
El Shikh ME, El Sayed RM, Tew JG, Szakal AK ( 2007 ) . Follicular dendritic cells stimulated by collagen type I develop dendrites and networks in vitro . Cell Tissue Res vol. 329 , ( 1 ) 81 - 89 .
Shikh MEME, Sayed RME, Wu Y, Szakal AK, Tew JG ( 2007 ) . Induction of human primary antibody responses in vitro by ovalbumin (OVA) or anthrax (rPA) on dendritic cells (DCs) and follicular dendritic cells (FDCs) in temporally controlled germinal center reactions (GCRs) . The Journal of Immunology vol. 178 , ( MeetingAbstracts )
El Shikh ME, El Sayed R, Szakal AK, Tew JG ( 2006 ) . Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development . Eur J Immunol vol. 36 , ( 10 ) 2715 - 2724 .
Szakal AK, El Shikh ME, Elsayed R, Tew JG ( 2006 ) . Influence of collagen on follicular dendritic cells to develop dendrites and reticula in vitro . JOURNAL OF IMMUNOLOGY . vol. 176 , S213 - S213 .
El Shikh ME, Elsayed R, Szakal AK, Tew JG ( 2006 ) . Interaction of immune complexes with Fc gamma RIIB on follicular dendritic cells upregulates Fc gamma RIIB expression as well as VCAM-1, ICAM-1 and CD320 . JOURNAL OF IMMUNOLOGY . vol. 176 , S75 - S75 .
El Shikh ME, Wu YZ, Elsayed R, Szakal AK, Tew JG ( 2006 ) . Interaction of poly(I : C) and LPS with toll receptors upregulates CR1/2, Fc gamma RIIB and VCAM-1 expression on follicular dendritic cells via NF-kappa B . JOURNAL OF IMMUNOLOGY . vol. 176 , S96 - S96 .