Publications: Prof John Connelly
Anderson CJ, Talmane L, Luft J, Connelly J, Nicholson MD, Verburg JC, Pich O, Campbell S et al.
(
2024
)
.
Strand-resolved mutagenicity of DNA damage and repair
.
Nature
vol.
630
,
(
8017
)
744
-
751
.
Ross R, Guo Y, Walker RN, Bergamaschi D, Shaw TJ, Connelly JT
(
2024
)
.
Biomechanical activation of keloid fibroblasts promotes lysosomal remodelling and exocytosis
.
Journal of Investigative Dermatology
Millar FR, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, Gautier P, Meynert A et al.
(
2022
)
.
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer
.
Cell Reports
vol.
41
,
(
6
)
Jones CFE, Di Cio S, Connelly JT, Gautrot JE
(
2022
)
.
Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model
.
Frontiers in Bioengineering and Biotechnology
vol.
10
,
Sarmin AM, Moussaid NE, Suntornnond R, Tyler EJ, Kim Y-H, Di Cio S, Megone WV, Pearce O et al.
(
2022
)
.
Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models
.
Biomolecules
vol.
12
,
(
6
)
Sarmin AM, Connelly JT
(
2022
)
.
Fabrication of Human Skin Equivalents Using Decellularized Extracellular Matrix
.
Current Protocols
vol.
2
,
(
3
)
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J et al.
(
2022
)
.
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging
.
Materials (Basel)
vol.
15
,
(
5
)
Pundel OJ, Blowes LM, Connelly JT
(
2022
)
.
Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function
.
Advanced Science
vol.
9
,
(
10
)
Hannen R, Connelly J, Myers S, Ojeh N
(
2022
)
.
Skin tissue engineering and keratinocyte stem cell therapy
.
Tissue Engineering, Third Edition
,
Connelly JT, Gavara N, Sliogeryte K, Blowes LM
(
2021
)
.
Research Techniques Made Simple: Analysis of Skin Cell and Tissue Mechanics Using Atomic Force Microscopy
.
Journal of Investigative Dermatology
vol.
141
,
(
8
)
1867
-
1871.e1
.
Singh B, Abdelgawad ME, Ali Z, Bailey J, Budyn E, Civita P, Clift MJD, Connelly JT et al.
(
2021
)
.
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings
.
Alternatives to Laboratory Animals
vol.
49
,
(
3
)
93
-
110
.
Wu Y, Fortunato GM, Okesola BO, Brocchetti FLPD, Suntornnond R, Connelly J, De Maria C, Rodriguez-Cabello JC et al.
(
2021
)
.
An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability
.
Biofabrication
vol.
13
,
(
3
)
Costa P, Blowes LM, Laly AC, Connelly JT
(
2021
)
.
Regulation of collective cell polarity and migration using dynamically adhesive micropatterned substrates
.
Acta Biomaterialia
vol.
126
,
291
-
300
.
Laly AC, Sliogeryte K, Pundel OJ, Ross R, Keeling MC, Avisetti D, Waseem A, Gavara N et al.
(
2021
)
.
The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction
.
Science Advances
vol.
7
,
(
5
)
Di Cio S, Iskratsch T, Connelly JT, Gautrot JE
(
2019
)
.
Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
.
Biomaterials
vol.
232
,
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al.
(
2019
)
.
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces
.
International Journal of Molecular Sciences
vol.
20
,
(
24
)
Blowes LM, Sliogeryte K, Gavara N, Connelly J
(
2019
)
.
268 Geometry-dependent chromatin remodelling in keratinocytes is altered by cell-cell adhesions
.
Journal of Investigative Dermatology
.
vol.
139
,
Almeida FV, Gammon L, Laly AC, Pundel OJ, Bishop CL, Connelly JT
(
2019
)
.
High‐Content Analysis of Cell Migration Dynamics within a Micropatterned Screening Platform
.
Advanced Biosystems1900011
-
1900011
.
Connelly JT
(
2019
)
.
Chapter One Biophysical regulation of epidermal fate and function
.
Epidermal Stem Cell Niche
,
vol.
3
,
Elsevier
Ghetti M, Topouzi H, Theocharidis G, Papa V, Williams G, Bondioli E, Cenacchi G, Connelly JT et al.
(
2018
)
.
Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic
.
British Journal of Dermatology
vol.
179
,
(
2
)
381
-
393
.
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT
(
2018
)
.
Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
.
Journal of Cell Science
vol.
131
,
(
10
)
Article
jcs215780
,
215780
-
215780
.
Li D, Sharili AS, Connelly J, Gautrot JE
(
2018
)
.
Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors
.
Biomacromolecules
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.
(
2017
)
.
Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers
.
Cancer Discov
Theocharidis G, Connelly JT
(
2017
)
.
Minor collagens of the skin with not so minor functions
.
Journal of Anatomy
vol.
235
,
(
2
)
418
-
429
.
GAUTROT JEE, Di Cio S, Boggild T, Connelly J, Sutherland DS
(
2016
)
.
Differential Integrin Expression Regulates Cell Sensing of the Matrix Nanoscale Geometry
.
Acta Biomaterialia
Kanapathy M, Hachach‐Haram N, Bystrzonowski N, Connelly JT, O'Toole EA, Becker DL, Mosahebi A, Richards T
(
2016
)
.
Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing
.
International Wound Journal
vol.
14
,
(
1
)
16
-
23
.
Sharili AS, Kenny FN, Vartiainen MK, Connelly JT
(
2016
)
.
Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes
.
Sci Rep
vol.
6
,
33893
-
33893
.
Kao AP, Connelly JT, Barber AH
(
2016
)
.
3D nanomechanical evaluations of dermal structures in skin
.
Journal of the mechanical behavior of biomedical materials
vol.
57
,
14
-
23
.
Wongkaew N, Connelly JT, Baeumner AJ
(
2016
)
.
Taking advantage of liposomes in microfluidic systems
.
Liposomes in Analytical Methodologies
,
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT
(
2016
)
.
Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility
.
J Invest Dermatol
vol.
136
,
(
1
)
74
-
83
.
Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT
(
2015
)
.
The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes
.
Journal of Cell Science
vol.
128
,
(
24
)
4475
-
4486
.
Dalbay MT, Thorpe SD, Connelly JT, Chapple JP, Knight MM
(
2015
)
.
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation
.
Stem Cells
vol.
33
,
(
6
)
1952
-
1961
.
Kenny FN, Connelly JT
(
2014
)
.
Integrin-mediated adhesion and mechano-sensing in cutaneous wound healing
.
Cell and Tissue Research
vol.
360
,
(
3
)
571
-
582
.
Costa P, Gautrot JE, Connelly JT
(
2014
)
.
Directing cell migration using micropatterned and dynamically adhesive polymer brushes
.
Acta Biomater
vol.
10
,
(
6
)
2415
-
2422
.
Sharili AS, Connelly JT
(
2014
)
.
Nucleocytoplasmic shuttling: a common theme in mechanotransduction
.
Biochem Soc Trans
vol.
42
,
(
3
)
645
-
649
.
McMurray RJ, Wann AKT, Thompson CL, Connelly JT, Knight MM
(
2013
)
.
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells
.
Sci Rep
vol.
3
,
Tan DW, Jensen KB, Trotter MW, Connelly JT, Broad S, Watt FM
(
2013
)
.
Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells
.
Development
vol.
140
,
(
7
)
1433
-
1444
.
Hosny NA, Song M, Connelly JT, Ameer-Beg S, Knight MM, Wheeler AP
(
2013
)
.
Super-resolution imaging strategies for cell biologists using a spinning disk microscope
.
PLoS One
vol.
8
,
(
10
)
Costa P, Almeida FVM, Connelly JT
(
2012
)
.
Biophysical signals controlling cell fate decisions: how do stem cells really feel?
.
Int J Biochem Cell Biol
vol.
44
,
(
12
)
2233
-
2237
.
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.
(
2012
)
.
Extracellular-matrix tethering regulates stem-cell fate
.
Nat Mater
vol.
11
,
(
7
)
642
-
649
.
Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW-M, Watt FM
(
2012
)
.
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo
.
J Invest Dermatol
vol.
132
,
(
4
)
1084
-
1093
.
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.
(
2012
)
.
Erratum: Extracellular-matrix tethering regulates stem-cell fate (Nature Materials (2012) 11 (642-649))
.
Nature Materials
vol.
11
,
(
8
)
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H et al.
(
2012
)
.
Extracellular-matrix tethering regulates stem-cell fate
.
Nature Materials
vol.
11
,
(
7
)
642
-
649
.
Connelly JT
(
2012
)
.
Terminal differentiation of human epidermal stem cells on micro-patterned substrates
.
Methods Mol Biol
vol.
916
,
15
-
22
.
Connelly JT, Petrie TA, García AJ, Levenston ME
(
2011
)
.
Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogels
.
Eur Cell Mater
vol.
22
,
168
-
176
.
Connelly JT, Mishra A, Gautrot JE, Watt FM
(
2011
)
.
Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation
.
PLoS One
vol.
6
,
(
11
)
Connelly JT, Gautrot JE, Trappmann B, Tan DW-M, Donati G, Huck WTS, Watt FM
(
2010
)
.
Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions
.
Nat Cell Biol
vol.
12
,
(
7
)
711
-
718
.
Connelly JT, Vanderploeg EJ, Mouw JK, Wilson CG, Levenston ME
(
2010
)
.
Tensile loading modulates bone marrow stromal cell differentiation and the development of engineered fibrocartilage constructs
.
Tissue Eng Part A
vol.
16
,
(
6
)
1913
-
1923
.
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM, Huck WTS
(
2010
)
.
Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale
.
Biomaterials
vol.
31
,
(
18
)
5030
-
5041
.
Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
(
2009
)
.
On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors
.
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
.
612
-
614
.
Connelly JT, Levenston ME
(
2008
)
.
Integrin ligand density regulates cytoskeletal organization and the differentiation of mesenchymal progenitors in RGD-modified agarose hydrogels
.
8th World Biomaterials Congress 2008
.
vol.
1
,
Connelly JT, García AJ, Levenston ME
(
2008
)
.
Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis
.
J Cell Physiol
vol.
217
,
(
1
)
145
-
154
.
Connelly JT, Wilson CG, Levenston ME
(
2008
)
.
Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs
.
Osteoarthritis Cartilage
vol.
16
,
(
9
)
1092
-
1100
.
Nugen SR, Asiello PJ, Connelly JT, Baeumner AJ
(
2008
)
.
PMMA biosensor for nucleic acids with integrated mixer and electrochemical detection
.
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
.
937
-
939
.
Mouw JK, Connelly JT, Wilson CG, Michael KE, Levenston ME
(
2007
)
.
Dynamic compression regulates the expression and synthesis of chondrocyte-specific matrix molecules in bone marrow stromal cells
.
Stem Cells
vol.
25
,
(
3
)
655
-
663
.
Connelly JT, García AJ, Levenston ME
(
2007
)
.
Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels
.
Biomaterials
vol.
28
,
(
6
)
1071
-
1083
.
Connelly JT, Vanderploeg EJ, Levenston ME
(
2004
)
.
The influence of cyclic tension amplitude on chondrocyte matrix synthesis: experimental and finite element analyses
.
Biorheology
vol.
41
,
(
3-4
)
377
-
387
.