Publications: Dr Egle Solito

Shah SN, Knausenberger TB-A, Pontifex MG, Connell E, Le Gall G, Hardy TAJ, Randall DW, McCafferty K et al. ( 2024 ) . Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor . Gut Microbes vol. 16 , ( 1 ) 2431651 - 2431651 .

Stolp HB, Solito E ( 2024 ) . Developmental priming of early cerebrovascular ageing: Implications across a lifetime . International Journal of Geriatric Psychiatry vol. 39 , ( 4 )

Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al. ( 2023 ) . The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing . Nature Metabolism

Cortese P, Amato F, Davino A, De Franchis R, Esposito S, Zollo I, Di Domenico M, Solito E et al. ( 2023 ) . The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy . Cells vol. 12 , ( 11 )

De Vitis C, Battaglia AM, Pallocca M, Santamaria G, Mimmi MC, Sacco A, De Nicola F, Gaspari M et al. ( 2023 ) . ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis . Journal of Experimental & Clinical Cancer Research vol. 42 , ( 1 )

Wickstead ES, Solito E, Mcarthur S ( 2022 ) . Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class . Life vol. 12 , ( 12 ) Article 2009 ,

Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al. ( 2022 ) . Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity . Circulation vol. 146 , ( 25 ) 1930 - 1945 .

Robbins JP, Solito E ( 2022 ) . Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions? . Frontiers in Neuroscience vol. 16 ,

Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD et al. ( 2021 ) . Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues . The FASEB Journal vol. 36 , ( 1 )

Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al. ( 2021 ) . Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide . Microbiome

Chee SEJ, Solito E ( 2021 ) . The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease . Frontiers in Immunology vol. 12 ,

Mohammad S, Zoubi SA, Collotta D, Krieg N, Wissuwa B, Alves GF, Purvis GSD, Norata GD et al. ( 2021 ) . A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice . Frontiers in Immunology vol. 12 , 701275 - 701275 .

Reis M, Watts H, Mota B, Yanez-lopez M, Donat C, Baxan N, Pickering J, Chaw T et al. ( 2021 ) . Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology . Brain: a journal of neurology

Mohammad S, Al Zoubi S, Krieg N, Wissuwa B, Baragetti A, Solito E, Brandenburg K, Collino M et al. ( 2021 ) . A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice . BRITISH JOURNAL OF PHARMACOLOGY . vol. 178 , 4998 - 4999 .

Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H et al. ( 2020 ) . Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming . Nature Communications vol. 11 ,

Majkowska A, Redondo-Gómez C, Rice A, Gonzalez M, Inostroza-Brito KE, Collin EC, Rodriguez-Cabello JC, Del Rio Hernandez AE et al. ( 2020 ) . Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures . Frontiers in Materials vol. 7 ,

Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S et al. ( 2020 ) . Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier . Journal of Neuroinflammation

Callender L, Carroll E, BOBER E, Akbar A, Solito E, Henson S ( 2019 ) . Mitochondrial mass governs the extent of human T cell senescence . Aging Cell vol. 19 , ( 2 )

Solito E, Montague-Cardoso, K, Pitcher T, Chisolm K, Salera G, Lindstrom E, Hewitt E, Malcangio M ( 2019 ) . Changes in vascular permeability in the spinal cord contribute to chemotherapy- induced neuropathic pain . Brain Behaviour and Immunity

Solito E, Zub E, Canet G, Garbelli R, Blaquiere M, Rossini L, Pastori C, Sheikh M et al. ( 2019 ) . The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy . The FASEB Journal

Solito E, Colamatteo A, Maggioli E, Azevedo Loiola R, Sheikh M, Cali G, Bruzzese D, Maniscalco T et al. ( 2019 ) . Reduced Annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients . Journal of Immunology

da Rocha GHO, Loiola RA, Pantaleão LDN, Reutelingsperger C, Solito E, Farsky SHP ( 2019 ) . Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis . Cell Biochemistry and Function

Loiola RA, Wickstead ES, Solito E, Mcarthur S ( 2019 ) . Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1 . Frontiers in Endocrinology

SOLITO EGLE, PURVIS G, THIEMERMANN C ( 2019 ) . Annexin-A1: therapeutic potential in microvascular disease . Frontiers in Immunology

Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D et al. ( 2019 ) . Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes . Frontiers in Immunology vol. 10 ,

Pickering J, Ries M, Solito E, Semmler A, Sastre M ( 2019 ) . Administration of annexin-A1 reduces tau phosphorylation in the tau-P301L mouse model . BRITISH JOURNAL OF PHARMACOLOGY . vol. 176 , 3024 - 3024 .

SOLITO E ( 2018 ) . Connections of Annexin A1 and Translocator Protein-18 KDa on Toll Like Receptor Stimulated BV-2 Cells . Exp Cell Res.

SOLITO E, SHEIKH M ( 2018 ) . Annexin A1: Uncovering the Many Talents of an Old Protein . International Journal of Molecular Sciences vol. 19 ,

S. D. Purvis G, Solito E ( 2018 ) . Is AnnexinA1 The Miracle Drug For Diabetes? . Science Trends

Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M et al. ( 2017 ) . Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes . Diabetologia

Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF et al. ( 2017 ) . The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1 . Journal of Biological Chemistry vol. 292 , ( 33 ) 13758 - 13773 .

Purvis GSD, Chiazza F, Collino M, Solito E, Thiemermann C ( 2017 ) . Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy . FASEB JOURNAL . Conference: FASEB vol. 31 ,

Purvis GSD, Chiazza F, Solito E, Collino M, Thiemermann C ( 2017 ) . Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy . DIABETIC MEDICINE . Conference: European Shock Society vol. 34 , 26 - 26 .

Purvis GSD, Loiola RA, Keswich J, Theimermann C, Solito E ( 2017 ) . Role of annexin-A1 on blood-brain barrier functionality . DIABETIC MEDICINE . vol. 34 , 64 - 64 .

McArthur S, Loiola RA, Maggioli, E, Errede M, Virgintino D, SOLITO E ( 2016 ) . The restorative role of annexin A1 at the blood–brain barrier . Fluids and Barriers of the CNS vol. 13 , ( 17 )

SOLITO E, Loiola R, Ries M, Shah U, Gentleamn S, Sastre M ( 2016 ) . The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide . Journal of Neuroinflammation vol. 13 ,

Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ ( 2016 ) . The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil . International Immunopharmacology vol. 32 , 87 - 95 .

Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M, Solito E ( 2015 ) . Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking . Brain Behavior and Immunity vol. 51 , 212 - 222 .

Yazid S, Gardner PJ, Carvalho L, Chu CJ, Flower RJ, Solito E, Lee RWJ, Ali RR et al. ( 2015 ) . Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease . Journal of Autoimmunity vol. 58 , 1 - 11 .

Mauro C, De Rosa V, Marelli-Berg F, Solito E ( 2015 ) . Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier . Frontiers in Immunology vol. 5 ,

Farsky SHP, Santin JR, Takahama C, Machado ID, Teixeira S, Muscara MN, Pitta IR, Solito E et al. ( 2014 ) . ANNEXIN A1 AND PPARγ ON RESOLUTION OF INFLAMMATION . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 286 - 286 .

dos Santos Queiroz CJ, de Amorim Gomes Nakata CM, Solito E, Damazo AS ( 2014 ) . Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer . Pathology vol. 46 ,

Queiroz CJDS, Nakata CMDAG, Solito E, Damazo AS ( 2014 ) . Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer . Infect Agent Cancer vol. 9 ,

Girol AP, Mimura KKO, Drewes CC, Bolonheis SM, Solito E, Farsky SHP, Gil CD, Oliani SM ( 2013 ) . Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro . J Immunol vol. 190 , ( 11 ) 5689 - 5701 .

Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al. ( 2013 ) . Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications . Proc Natl Acad Sci U S A vol. 110 , ( 3 ) 832 - 841 .

Yazid S, Sinniah A, Solito E, Calder V, Flower RJ ( 2013 ) . Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1 . PLoS One vol. 8 , ( 3 )

Mehet DK, Philip J, Solito E, Buckingham JC, John CD ( 2012 ) . Evidence from in vitro and in vivo studies showing that nuclear factor-κB within the pituitary folliculostellate cells and corticotrophs regulates adrenocorticotrophic hormone secretion in experimental endotoxaemia . J Neuroendocrinol vol. 24 , ( 6 ) 862 - 873 .

Solito E, Sastre M ( 2012 ) . Microglia function in Alzheimer's disease . Front Pharmacol vol. 3 ,

McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E ( 2010 ) . Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia . J Immunol vol. 185 , ( 10 ) 6317 - 6328 .

Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M, Flower RJ ( 2010 ) . Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization . Arterioscler Thromb Vasc Biol vol. 30 , ( 9 ) 1718 - 1724 .

Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ ( 2010 ) . Anti-allergic drugs and the Annexin-A1 system . Pharmacol Rep vol. 62 , ( 3 ) 511 - 517 .

McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, Solito E ( 2009 ) . Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization . FASEB J vol. 23 , ( 11 ) 4000 - 4010 .

Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R ( 2009 ) . Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1 . Biochem Pharmacol vol. 77 , ( 12 ) 1814 - 1826 .

McArthur S, Prasongchean W, Gillies G, Solito E ( 2008 ) . A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis . FUND CLIN PHARMACOL vol. 22 , 23 - 23 .

Yazid S, Solito E, Christian H, Goulding N, Flower R ( 2008 ) . Further studies on the rapid glucocorticoid effects in the U937 monocytic cell line and its potentiation by cromoglycate-like drugs . FUND CLIN PHARMACOL vol. 22 , 47 - 47 .

Solito E, McArthur S, Christian H, Gavins F, Buckingham JC, Gillies GE ( 2008 ) . Annexin A1 in the brain--undiscovered roles? . Trends Pharmacol Sci vol. 29 , ( 3 ) 135 - 142 .

Damazo AS, Flower RJ, Solito E, Oliani SM ( 2008 ) . Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia . INFLAMM RES vol. 57 , ( 3 ) 97 - 103 .

Hu NJ, Bradshaw J, Lauter H, Buckingham J, Solito E, Hofmann A ( 2008 ) . Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: Implications for annexin-induced membrane aggregation . BIOPHYS J vol. 94 , ( 5 ) 1773 - 1781 .

John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E et al. ( 2007 ) . Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides . FASEB J vol. 21 , ( 4 ) 1037 - 1046 .

Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE et al. ( 2006 ) . Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue . AM J PHYSIOL-ENDOC M vol. 291 , ( 6 ) E1264 - E1273 .

Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E, Perretti M ( 2006 ) . Antiflammin-2 activates the human formyl-peptide receptor like 1 . ScientificWorldJournal vol. 6 , 1375 - 1384 .

Buckingham J, John C, Solito E, Flower R, Christian H, Morris J ( 2006 ) . Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface . ACTA PHARMACOL SIN vol. 27 , 1 - 1 .

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, Parente L ( 2006 ) . Down-regulation of annexin-1 expression in thyroid cancers is associated with tumour aggressiveness . ACTA PHARMACOL SIN vol. 27 , 65 - 65 .

FLOWER RJ, Buckingham JC, Tierney T, Festa M, Christian HC, Solito E, Mulla A ( 2006 ) . Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface . Faseb J vol. 20 , ( 9 ) 1498 - 1500 .

Solito E, Christian HC, Festa M, Mulla A, Tierney T, Flower RJ, Buckingham JC ( 2006 ) . Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface . FASEB J vol. 20 , ( 9 ) 1498 - 1500 .

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, Parente L ( 2006 ) . Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation . Cancer Biol Ther vol. 5 , ( 6 ) 643 - 647 .

Buckingham JC, Sahni V, Morris JF, Christian HC, Solito E, John CD ( 2006 ) . Annexin 1 dependent actions of glucocorticoids in the anterior pituitary gland - role of the formyl peptide receptor family . FRONTIERS IN NEUROENDOCRINOLOGY . vol. 27 , 53 - 54 .

Buckingham JC, Mulla A, Tierney T, Morris J, Christian HC, Solito E ( 2006 ) . The cellular exportation of annexin 1 requires post-translational modification . FRONTIERS IN NEUROENDOCRINOLOGY . vol. 27 , 85 - 85 .

Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva WA, Tajara E, Buckingham JC, Solito E ( 2006 ) . In vitro and in vivo studies on CCR10 regulation by Annexin A1 (vol 580, pg 1431, 2006) . FEBS LETT vol. 580 , ( 7 ) 1908 - 1908 .

Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M ( 2006 ) . Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement . BLOOD vol. 107 , ( 5 ) 2123 - 2130 .

Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva Júnior WA, Tajara E, Buckingham JC, Solito E ( 2006 ) . In vitro and in vivo studies on CCR10 regulation by Annexin A1 . FEBS Lett vol. 580 , ( 5 ) 1431 - 1438 .

Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Christian H, Morris J ( 2006 ) . Annexin 1, glucocorticoids, and the neuroendocrine-immune interface . NEUROENDOCRINE AND IMMUNE CROSSTALK . Editors: Chrousos, GP, Kaltsas, GA, Mastorakos, G , vol. 1088 , 396 - 409 .

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, Parente L ( 2005 ) . Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells . Cell Death Differ vol. 12 , ( 10 ) 1358 - 1360 .

Rodrigues-Lisoni FC, Oliani S, Buckingham J, Solito E, Tajara EH ( 2005 ) . Annexin A1: From gene organization to physiology . Annexins vol. 2 , ( 2 )

Mulla A, Leroux C, Solito E, Buckingham JC ( 2005 ) . Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function . J Clin Endocrinol Metab vol. 90 , ( 1 ) 557 - 562 .

Perretti M, Solito E ( 2004 ) . Annexin 1 and neutrophil apoptosis . BIOCHEMICAL SOCIETY TRANSACTIONS vol. 32 , 507 - 510 .

John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JC ( 2004 ) . Annexin 1 and the regulation of endocrine function . TRENDS ENDOCRIN MET vol. 15 , ( 3 ) 103 - 109 .

Parente L, Solito E ( 2004 ) . Annexin 1: more than an anti-phospholipase protein . Inflamm Res vol. 53 , ( 4 ) 125 - 132 .

Mulla A, Christian HC, Solito E, Mendoza N, Morris JF, Buckingham JC ( 2004 ) . Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma . Clin Endocrinol (Oxf) vol. 60 , ( 1 ) 107 - 119 .

Tierney T, Christian HC, Morris JF, Solito E, Buckingham JC ( 2003 ) . Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release . J Neuroendocrinol vol. 15 , ( 12 ) 1134 - 1143 .

John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JC ( 2003 ) . Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides . J Neuroendocrinol vol. 15 , ( 10 ) 946 - 957 .

Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H, Morris J ( 2003 ) . Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system . Cell Biochem Funct vol. 21 , ( 3 ) 217 - 221 .

Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H, Morris J ( 2003 ) . Annexin 1: a paracrine/juxtacrine mediator of glucorticoid in the action in the neuroendocrine system . CELL BIOCHEMISTRY AND FUNCTION . vol. 21 , 217 - 221 .

de Coupade C, Solito E, Levine JD ( 2003 ) . Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937 . Br J Pharmacol vol. 140 , ( 1 ) 133 - 145 .

Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M ( 2003 ) . A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils . FASEB J vol. 17 , ( 9 ) 1544 - + .

Croxtall JD, Gilroy DW, Solito E, Choudhury Q, Ward BJ, Buckingham JC, Flower RJ ( 2003 ) . Attenuation of glucocorticoid functions in an Anx-A1-/- cell line . Biochem J vol. 371 , ( Pt 3 ) 927 - 935 .

Solito E, Mulla A, Morris JF, Christian HC, Flower RJ, Buckingham JC ( 2003 ) . Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase . ENDOCRINOLOGY vol. 144 , ( 4 ) 1164 - 1174 .

Solito E, Perretti M ( 2003 ) . Exogenous annexin 1 promotes human neutrophil apoptosis . BRITISH JOURNAL OF PHARMACOLOGY . vol. 138 , U7 - U7 .

PERRETTI M, Marullo S, Buckingham JC, Russo-Marie F, Solito E, Kamal A ( 2003 ) . A novel calcium-dependent pro-apoptotic effect of annexin 1 on human neutrophils . FASEB J . vol. 17 , 1544 - 1546 .

FLOWER RJ, John C, Solito E, Morris J, Tierney T, Taylor A, Christian H, Buckingham JC ( 2003 ) . Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system . Cell Biochemistry and Function. vol. 21 , ( 3 ) 217 - 221 .

FLOWER RJ, Morris JF, Christian HC, Buckingham JC, Solito E, John CD ( 2003 ) . Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides . J Neuroendocrinol. vol. 15 , ( 10 ) 946 - 957 .

Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN ( 2002 ) . Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor . Nat Med vol. 8 , ( 11 ) 1296 - 1302 .

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C ( 2002 ) . Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model . J Immunol vol. 169 , ( 4 ) 2085 - 2092 .

Perretti M, La M, Solito E ( 2002 ) . Annexin 1 interacts with L-selectin following neutrophil adhesion to endothelial cells . FASEB J . vol. 16 , A1049 - A1049 .

Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C ( 2002 ) . Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo . FASEB J . vol. 16 , A598 - A598 .

Solito E, Mulla A, Buckingham JC ( 2002 ) . Dexamethasone induces serine phosphorylation of annexin 1: Involvement of PKC and PI3-kinase . BRIT J PHARMACOL vol. 135 ,

Mulla A, Buckingham JC, Solito E ( 2002 ) . LPS acts via IL-6 and IL-1 to modulate the expression and phosphorylation of annexin 1 in cell lines derived from the putative microglia of the neuroendocrine system . BRIT J PHARMACOL vol. 135 ,

Solito E, Mulla A, Flower RJ, Buckingham JC ( 2002 ) . Lipocortin 1 (Annexin 1) . Wiley Encyclopedia of Molecular Medicine , Wiley

FLOWER RJ, Buckingham J, Christian H, Solito E, John C, Cover P, Morris J ( 2002 ) . Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C . Endocrinology. vol. 143 , ( 8 ) 3060 - 3070 .

de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M, Solito E ( 2001 ) . Cytokine modulation of liver annexin 1 expression during experimental endotoxemia . AM J PATHOL vol. 159 , ( 4 ) 1435 - 1443 .

Kamal AM, Smith SF, De Silva Wijayasinghe M, Solito E, Corrigan CJ ( 2001 ) . An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro . Clin Exp Allergy vol. 31 , ( 7 ) 1116 - 1125 .

Perretti M, Getting SJ, Solito E, Murphy PM, Gao JL ( 2001 ) . Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics . AM J PATHOL vol. 158 , ( 6 ) 1969 - 1973 .

John CD, Solito E, Mulla A, Morris JF, Flower RJ, Buckingham JC ( 2001 ) . Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism . BRIT J PHARMACOL vol. 133 , U20 - U20 .

Solito E, de Coupade C, Canaider S, Goulding NJ, Perretti M ( 2001 ) . Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation . BRIT J PHARMACOL vol. 133 , ( 2 ) 217 - 228 .

Solito E, Tissot M, Russo-Marie F, Marullo S ( 2000 ) . Extracellular annexin-1 accelerates apoptosis of human polymorphonuclears neutrophils . MOL BIOL CELL vol. 11 , 462A - 463A .

D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM, Perretti M ( 2000 ) . Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment . FASEB J vol. 14 , ( 13 ) 1867 - 1869 .

Solito E, Romero IA, Marullo S, Russo-Marie F, Weksler BB ( 2000 ) . Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin . J Immunol vol. 165 , ( 3 ) 1573 - 1581 .

Mulla A, Christian H, Morris J, Mendoza N, Solito E, Buckingham J ( 2000 ) . Expression of annexins 1 and 5 in human pituitary tumours . J PHYSIOL-LONDON vol. 525 , 53P - 54P .

Solito E, Tissot M, Russo-Marie F, Marullo S ( 2000 ) . Extracellular Annexin 1 induces apoptosis of human polymorphonuclear neutrophils . FASEB J vol. 14 , ( 8 ) A1357 - A1357 .

Le Maire V, Solito E, Russo-Marie F, Hernvann A, Le Marechal H, Ekindjian OG, Aussel C ( 2000 ) . System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger . J Cell Physiol vol. 183 , ( 1 ) 65 - 73 .

Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ, Perretti M ( 2000 ) . Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I) . Life Sci vol. 66 , ( 18 ) PL265 - PL270 .

Perretti M, Solito E, La M, Russo-Marie F, Marullo S, D'Amico M, Flower RJ ( 2000 ) . Annexin 1 activates human neutrophils: A mechanism for its anti-inflammatory in vivo effect . FASEB J vol. 14 , ( 4 ) A8 - A8 .

de Coupade C, Gillet R, Bennoun M, Briand P, Russo-Marie F, Solito E ( 2000 ) . Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice . Hepatology vol. 31 , ( 2 ) 371 - 380 .

D'Amico M, Di Filippo C, Solito E, Flower RJ, Perretti M ( 2000 ) . Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration . BRIT J PHARMACOL vol. 129 , U56 - U56 .

Gidon-Jeangirard C, Solito E, Hofmann A, Russo-Marie F, Freyssinet JM, Martínez MC ( 1999 ) . Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells . Biochem Biophys Res Commun vol. 265 , ( 3 ) 709 - 715 .

Young KA, Hirst WD, Solito E, Wilkin GP ( 1999 ) . De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum . Glia vol. 26 , ( 4 ) 333 - 343 .

John CD, Cover PO, Taylor AD, Morris JF, Flower RJ, Solito E, Buckingham JC ( 1999 ) . Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26 . BRIT J PHARMACOL vol. 126 , U74 - U74 .

Canaider S, Solito E, Goulding NJ, Flower RJ, Perretti M ( 1999 ) . Increased apoptosis in cells overexpressing lipocortin 1 . BRIT J PHARMACOL vol. 126 , U26 - U26 .

Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL, Streichenberger G ( 1999 ) . Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway . Biochem Pharmacol vol. 57 , ( 4 ) 433 - 443 .

Raugei G, Degl'Innocenti D, Chiarugi P, Solito E, Modesti A, Ramponi G ( 1999 ) . Preferential accumulation of muscle type acylphosphatase in the nucleus during differentiation . Biochem Mol Biol Int vol. 47 , ( 1 ) 127 - 136 .

Lim LH, Solito E, Russo-Marie F, Flower RJ, Perretti M ( 1998 ) . Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 . Proc Natl Acad Sci U S A vol. 95 , ( 24 ) 14535 - 14539 .

Solito E, Raguenes-Nicol C, de Coupade C, Bisagni-Faure A, Russo-Marie F ( 1998 ) . U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity . Br J Pharmacol vol. 124 , ( 8 ) 1675 - 1683 .

Solito E, de Coupade C, Parente L, Flower RJ, Russo-Marie F ( 1998 ) . IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein . Cytokine vol. 10 , ( 7 ) 514 - 521 .

Solito E, de Coupade C, Parente L, Flower RJ, Russo-Marie F ( 1998 ) . Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1 . Cell Growth Differ vol. 9 , ( 4 ) 327 - 336 .

Dubois T, Mira JP, Feliers D, Solito E, Russo-Marie F, Oudinet JP ( 1998 ) . Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration . Biochem J vol. 330 ( Pt 3) , ( Pt 3 ) 1277 - 1282 .

Lim LHK, Getting SJ, Das AM, Solito E, Flower RJ, Perretti M ( 1997 ) . Inhibition of neutrophil : endothelium interaction in murine post-capillary venules by lipocortin 1 . BRIT J PHARMACOL vol. 122 , U54 - U54 .

Voermans PH, Go KG, Horst GJT, Ruiters MHJ, Solito E, Parente L ( 1997 ) . P-3-325 Steroid-induced expression of annexinin brain . Clinical Neurology and Neurosurgery vol. 99 , s145 - s146 .

Voermans PH, Go KG, ter Horst GJ, Ruiters MHJ, Solito E, Parente L ( 1997 ) . Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs . Brain Edema X , vol. 70 , Springer Nature

Voermans PH, Go KG, ter Horst GJ, Ruiters MH, Solito E, Parente L ( 1997 ) . Expression of annexin and annexin-mRNA in rat brain under influence of steroid drugs . Acta Neurochir Suppl vol. 70 , 222 - 224 .

Cifone MG, Cironi L, Roncaioli P, Martinotti S, Toniato E, Cilenti L, Botti D, Solito E et al. ( 1996 ) . Phospholipase A(2) activity and calpactin I levels in rat lymphokine-activated killer cells: Correlation with the cytotoxic activity . CELL IMMUNOL vol. 170 , ( 2 ) 274 - 282 .

Ambrosetti DC, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L, Melli M ( 1996 ) . Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta . Eur J Biochem vol. 238 , ( 2 ) 308 - 316 .

Voermans PH, Go KG, Horst GJ, Ruiters MH, Solito E, Parente L ( 1996 ) . Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F . Mediators Inflamm vol. 5 , ( 5 ) 370 - 378 .

Parente L, Ambrosetti D, Palla E, Mirtella A, Galeotti CL, Solito E, Navarra P, Melli M ( 1995 ) . A new functional binding site for interleukin-1beta? . Pharmacological Research vol. 31 ,

Parente L, Solito E ( 1994 ) . Association between glucocorticosteroids and lipocortin 1 . Trends Pharmacol Sci vol. 15 , ( 10 )

Solito E, Nuti S, Parente L ( 1994 ) . Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells . Br J Pharmacol vol. 112 , ( 2 ) 347 - 348 .

PARENTE L, NUTI S, SOLITO E ( 1994 ) . DEXAMETHASONE INDUCES THE TRANSLOCATION OF LIPOCORTIN-1 TO THE MEMBRANE OF HUMAN MONOCYTIC U-937 CELLS . BRIT J PHARMACOL vol. 111 , P72 - P72 .

GO KG, ZUIDERVEEN F, DELEY L, TERHAAR JG, PARENTE L, SOLITO E, MOLENAAR WM ( 1994 ) . EFFECT OF STEROIDS ON BRAIN LIPOCORTIN IMMUNOREACTIVITY . ACTA NEUROCHIR101 - 103 .

Go KG, Zuiderveen F, De Ley L, Ter Haar JG, Parente L, Solito E, Molenaar WM ( 1994 ) . Effect of steroids on brain lipocortin immunoreactivity . Acta Neurochir Suppl (Wien) vol. 60 , 101 - 103 .

SOLITO E, PALLA E, BENSI G, FASSINA G, MELLI M, PARENTE L ( 1994 ) . IDENTIFICATION OF ACTIVE-SITES OF INTERLEUKIN-1-BETA BY LOOP SUBSTITUTION AND SITE-DIRECTED MUTAGENESIS . BRIT J PHARMACOL vol. 111 , P31 - P31 .

Go KG, Ter Haar JG, de Ley L, Zuiderveen F, Parente L, Solito E, Molenaar WM ( 1994 ) . The effect of steroid treatment on lipocortin immunoreactivity of rat brain . Mediators Inflamm vol. 3 , ( 3 ) 177 - 180 .

De Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E et al. ( 1993 ) . Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids . J Appl Physiol (1985) vol. 75 , ( 6 ) 2368 - 2375 .

Palla E, Bensi G, Solito E, Buonamassa DT, Fassina G, Raugei G, Spano F, Galeotti C et al. ( 1993 ) . Loop substitution as a tool to identify active sites of interleukin-1 beta . J Biol Chem vol. 268 , ( 18 ) 13486 - 13492 .

BECHERUCCI C, PERRETTI M, SOLITO E, GALEOTTI CL, PARENTE L ( 1993 ) . CONCEIVABLE DIFFERENCE IN THE ANTIINFLAMMATORY MECHANISMS OF LIPOCORTIN-1 AND LIPOCORTIN-5 . MEDIAT INFLAMM vol. 2 , ( 2 ) 109 - 113 .

RUBARTELLI A, BAJETTO A, BONIFACI N, DIBLAS E, SOLITO E, SITIA R ( 1993 ) . A NOVEL WAY TO GET OUT OF THE CELL . CYTOTECHNOLOGY . vol. 11 , 37 - 40 .

Rubartelli A, Bajetto A, Bonifaci N, Di Blas E, Solito E, Sitia R ( 1993 ) . A novel way to get out of the cell . Cytotechnology vol. 11 Suppl 1 , S37 - S40 .

Becherucci C, Perretti M, Solito E, Galeotti CL, Parente L ( 1993 ) . Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5 . Mediators Inflamm vol. 2 , ( 2 ) 109 - 113 .

Solito E, De Caterina R, Giannessi D, Paggiaro PL, Sicari R, Parente L ( 1993 ) . Studies on the induction of lipocortin-1 by glucocorticoids . Ann Ist Super Sanita vol. 29 , ( 3 ) 391 - 394 .

Parente L, Solito E, Giannessi P, Paggiari P, Sicari R, De Caterina R ( 1992 ) . Inhibition of eicosanoid formation and lipocortin induction by glucocorticoids in human cell lines and in patients with inflammatory lung disease . Pharmacol Res vol. 26 Suppl 2 , 44 - 45 .

Parente L, Galeotti CL, Ghiara P, Melli M, Mugridge KG, Solito E ( 1992 ) . Mechanisms of IL-1 different biological activities. Studies using IL-1 muteins and IL-1 receptor antibodies . Pharmacological Research vol. 26 ,

Perretti M, Solito E, Parente L ( 1992 ) . Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice . Agents Actions vol. 35 , ( 1-2 ) 71 - 78 .

Solito E, Raugei G, Melli M, Parente L ( 1992 ) . Glucocorticoid effect on lipocortin mRNA expression in U-937 cells . Pharmacol Res vol. 25 Suppl 1 , 13 - 14 .

de Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E et al. ( 1992 ) . Induction of synthesis of lipocortin-I and inhibition of eicosanoid production in inflammatory cells: Evidence for a cell selectivity in glucocorticoid action . Thrombosis Research vol. 65 ,

SOLITO E, RAUGEI G, MELLI M, PARENTE L ( 1991 ) . DEXAMETHASONE INDUCES THE EXPRESSION OF THE MESSENGER-RNA OF LIPOCORTIN-1 AND LIPOCORTIN-2 AND THE RELEASE OF LIPOCORTIN-1 AND LIPOCORTIN-5 IN DIFFERENTIATED, BUT NOT UNDIFFERENTIATED U-937 CELLS . FEBS LETT vol. 291 , ( 2 ) 238 - 244 .

Solito E, Raugei G, Melli M, Parente L ( 1991 ) . Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells . FEBS Lett vol. 291 , ( 2 ) 238 - 244 .

Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S, Parente L ( 1991 ) . A novel anti-inflammatory peptide from human lipocortin 5 . Br J Pharmacol vol. 103 , ( 2 ) 1327 - 1332 .

SOLITO E, RAUGEI G, MELLI M, PARENTE L ( 1991 ) . EFFECT OF DEXAMETHASONE AND PHORBOL-MYRISTATE ACETATE ON LIPOCORTIN-1, LIPOCORTIN-2 AND LIPOCORTIN-5 MESSENGER-RNA AND PROTEIN-SYNTHESIS . ADV PROSTAG THROMB L vol. 21 , 291 - 294 .

Solito E, Raugei G, Melli M, Parente L ( 1991 ) . Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis . Adv Prostaglandin Thromboxane Leukot Res vol. 21A , 291 - 294 .

Boraschi D, Villa L, Ghiara P, Tagliabue A, Mengozzi M, Solito E, Parente L, Silvestri S et al. ( 1991 ) . Mechanism of acute toxicity of IL-1 beta in mice . Eur Cytokine Netw vol. 2 , ( 1 ) 61 - 67 .

Parente L, Mugridge KG, Perretti M, Solito E ( 1990 ) . In vitro and in vivo activation of phospholipase A2 by interleukin-1 . Pharmacological Research vol. 22 ,

Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M et al. ( 1990 ) . Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? . Prog Clin Biol Res vol. 349 , 55 - 68 .

Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL, Parente L ( 1990 ) . Purification and biological activity of human lipocortin 2 . Pharmacol Res vol. 22 Suppl 1 , 29 - 30 .

Solito E, Parente L ( 1989 ) . Modulation of phospholipase A2 activity in human fibroblasts . Br J Pharmacol vol. 96 , ( 3 ) 656 - 660 .

SOLITO E, PARENTE L ( 1988 ) . ACTIVATION OF PHOSPHOLIPASE-A2 BY INTERLEUKIN-1 IN HUMAN-FIBROBLASTS . LYMPHOKINE RES vol. 7 , ( 3 ) 261 - 261 .

Solito E, Busoni P, Bini L ( 1985 ) . [Relational perspective in a district service for the substance-dependent] . Minerva Psichiatr vol. 26 , ( 3 ) 267 - 269 .