Publications: Dr Sarah Martin
Brooksbank K, Martin SA
(
2023
)
.
DNA mismatch repair deficient cancer – Emerging biomarkers of resistance to immune checkpoint inhibition
.
The International Journal of Biochemistry & Cell Biology
vol.
164
,
Dullovi A, Ozgencil M, Rajvee V, Tse WY, Cutillas PR, Martin SA, Hořejší Z
(
2023
)
.
Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
.
iScience
vol.
26
,
(
3
)
Carpentier J, Szlosarek P, Martin SA
(
2022
)
.
179 (PB059) The combination of the metabolism-based targeted therapies ADI-PEG20 and GC7 are a promising strategy for the treatment of malignant pleural mesothelioma
.
European Journal of Cancer
vol.
174
,
Shailes H, Tse WY, Freitas MO, Silver A, Martin SA
(
2022
)
.
Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer
.
Frontiers in Oncology
vol.
12
,
Dell’Anno I, Melani A, Martin SA, Barbarino M, Silvestri R, Cipollini M, Giordano A, Mutti L et al.
(
2022
)
.
A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma
.
Cancers
vol.
14
,
(
10
)
Hoare JI, Osmani B, O’Sullivan EA, Browne A, Campbell N, Metcalf S, Nicolini F, Saxena J et al.
(
2022
)
.
Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy
.
Communications Biology
vol.
5
,
(
1
)
Davidson K, Grevitt P, Contreras-Gerenas MF, Bridge KS, Hermida M, Shah KM, Mardakheh FK, Stubbs M et al.
(
2021
)
.
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
.
Cell Death & Disease
vol.
12
,
(
11
)
Cucchi D, Gibson A, Martin SA
(
2021
)
.
The emerging relationship between metabolism and DNA repair
.
Cell Cycle
vol.
20
,
(
10
)
943
-
959
.
Silva VL, Saxena J, Nicolini F, Hoare JI, Metcalf S, Martin SA, Lockley M
(
2021
)
.
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
.
Cell Death & Disease
vol.
12
,
(
4
)
Dell'Anno I, Martin SA, Barbarino M, Melani A, Silvestri R, Bottaro M, Paolicchi E, Corrado A et al.
(
2020
)
.
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma
.
Invest New Drugs
vol.
39
,
(
1
)
1
-
14
.
Martin S
(
2019
)
.
MLH1 deficiency leads to deregulated mitochondrial metabolism
.
Cell Death and Disease
vol.
10
,
795
-
795
.
Guillotin D, Austin P, Begum R, Freitas MO, Merve A, Brend T, Short S, Marino S et al.
(
2017
)
.
Drug-Repositioning Screens Identify Triamterene as a Selective Drug for the Treatment of DNA Mismatch Repair Deficient Cells
.
Clinical Cancer Research
vol.
23
,
(
11
)
2880
-
2890
.
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al.
(
2016
)
.
Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
.
Cell Reports
vol.
16
,
(
6
)
1604
-
1613
.
Begum R, Martin S
(
2016
)
.
373 Targeting mismatch repair deficiency in endometrial cancer
.
European Journal of Cancer
vol.
61
,
s76
-
s77
.
Tookman L, Ashley B, Connell C, Bridge G, Ingemarsdotter C, Dowson S, Shibata A, Michelle L et al.
(
2016
)
.
570 RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer
.
European Journal of Cancer
vol.
61
,
Martin SA
(
2016
)
.
The DNA mismatch repair pathway
.
DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition
,
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al.
(
2016
)
.
Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma
.
Cancer Research
Rashid S, Bridge G, Yao Z, Szabadkai G, Martin SA
(
2016
)
.
Targeting the mitochondria for the treatment of MLH1-deficient disease
.
Journal of Clinical Oncology
.
vol.
34
,
e23182
-
e23182
.
Begum R, Martin SA
(
2016
)
.
Targeting Mismatch Repair defects: A novel strategy for personalized cancer treatment
.
DNA Repair
vol.
38
,
135
-
139
.
Tookman LA, Browne AK, Connell CM, Bridge G, Ingemarsdotter CK, Dowson S, Shibata A, Lockley M et al.
(
2016
)
.
RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer
.
Molecular Cancer Research
vol.
14
,
(
1
)
44
-
55
.
Martin SA
(
2016
)
.
Chapter 6 The DNA mismatch repair pathway
.
DNA Repair in Cancer Therapy
,
Elsevier
Tookman L, Ashley B, Connell C, Bridge G, Ingemarsdotter C, Dowson S, Shibata A, Michelle L et al.
(
2016
)
.
RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer
.
EUROPEAN JOURNAL OF CANCER
.
vol.
61
,
S124
-
S124
.
Begum R, Martin S
(
2016
)
.
Targeting mismatch repair deficiency in endometrial cancer
.
EUROPEAN JOURNAL OF CANCER
.
vol.
61
,
S76
-
S77
.
Guillotin D, Martin SA
(
2014
)
.
Exploiting DNA mismatch repair deficiency as a therapeutic strategy
.
Exp Cell Res
vol.
329
,
(
1
)
110
-
115
.
Stewart GD, O'Mahony FC, Laird A, Rashid S, Martin SA, Eory L, Lubbock ALR, Nanda J et al.
(
2014
)
.
Carbonic anhydrase 9 expression increases with vascular endothelial growth factor-targeted therapy and is predictive of outcome in metastatic clear cell renal cancer
.
Eur Urol
vol.
66
,
(
5
)
956
-
963
.
Payne HL, Martin S-A, Short SC
(
2014
)
.
OP01MISMATCH REPAIR DEFICIENCY CONFERS INCREASED SENSITIVITY TO IONISING RADIATION (XR) IN GLIOBLASTOMA
.
Neuro-Oncology
vol.
16
,
(
suppl_6
)
vi16
-
vi16
.
Swampillai A, Brierley D, Galavotti S, Lampada A, Shaked-Rabi M, McEvoy A, Brandner S, Martin S-A et al.
(
2014
)
.
P53THE METABOLIC AUTOPHAGY PATHWAY REGULATES THE RESPONSE TO TEMOZOLOMIDE IN GLIOBLASTOMA MULTIFORME-INITIATING STEM CELLS
.
Neuro-Oncology
vol.
16
,
(
suppl_6
)
vi9
-
vi9
.
Hewish M, Fontebasso Y, Martin SA, Elliott R, Perks KL, Konde A, Bajrami I, Weverwijk AV et al.
(
2014
)
.
Abstract 2931: Cancer cells deficient in DNA mismatch repair (MMR) are selectively sensitive to inhibition of the DNA dependent protein kinase (DNA-PK)
.
Conference:
Experimental and Molecular Therapeutics2931
-
2931
.
Bridge G, Rashid S, Martin SA
(
2014
)
.
DNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatment
.
Cancers (Basel)
vol.
6
,
(
3
)
1597
-
1614
.
Brierley DJ, Martin SA
(
2013
)
.
Oxidative stress and the DNA mismatch repair pathway
.
Antioxid Redox Signal
vol.
18
,
(
18
)
2420
-
2428
.
Hewish M, Martin SA, Elliott R, Cunningham D, Lord CJ, Ashworth A
(
2013
)
.
Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress
.
Br J Cancer
vol.
108
,
(
4
)
983
-
992
.
Hewish M, Lord CJ, Martin SA, Cunningham D, Ashworth A
(
2011
)
.
Abstract 350: High-throughput drug screens identify novel synthetic lethal interactions with MLH1-deficient cancers
.
Cancer Research
vol.
71
,
(
8_Supplement
)
350
-
350
.
Martin SA, Hewish M, Sims D, Lord CJ, Ashworth A
(
2011
)
.
Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers
.
Cancer Res
vol.
71
,
(
5
)
1836
-
1848
.
MARTIN S
(
2011
)
.
Mitochondrial DNA repair
.
DNA Repair - On the pathways to fixing DNA damage and errors
,
INTECH
Martin SA, Lord CJ, Ashworth A
(
2010
)
.
Therapeutic targeting of the DNA mismatch repair pathway
.
Clin Cancer Res
vol.
16
,
(
21
)
5107
-
5113
.
Hewish M, Lord CJ, Martin SA, Cunningham D, Ashworth A
(
2010
)
.
Mismatch repair deficient colorectal cancer in the era of personalized treatment
.
Nat Rev Clin Oncol
vol.
7
,
(
4
)
197
-
208
.
Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E et al.
(
2010
)
.
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1
.
Cancer Cell
vol.
17
,
(
3
)
235
-
248
.
Martin SA, Hewish M, Lord CJ, Ashworth A
(
2010
)
.
Genomic instability and the selection of treatments for cancer
.
J Pathol
vol.
220
,
(
2
)
281
-
289
.
Martin SA, McCarthy A, Barber LJ, Burgess DJ, Parry S, Lord CJ, Ashworth A
(
2009
)
.
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
.
EMBO Mol Med
vol.
1
,
(
6-7
)
323
-
337
.
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim J-S, Waldman T, Lord CJ et al.
(
2009
)
.
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
.
EMBO Mol Med
vol.
1
,
(
6-7
)
315
-
322
.
Lord CJ, Martin SA, Ashworth A
(
2009
)
.
RNA interference screening demystified
.
J Clin Pathol
vol.
62
,
(
3
)
195
-
200
.
Martin SA, Ouchi T
(
2008
)
.
Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN
.
Mol Cancer Ther
vol.
7
,
(
8
)
2509
-
2516
.
Martin SA, Lord CJ, Ashworth A
(
2008
)
.
DNA repair deficiency as a therapeutic target in cancer
.
Curr Opin Genet Dev
vol.
18
,
(
1
)
80
-
86
.
Tawara H, Fujiuchi N, Sironi J, Martin S, Aglipay J, Ouchi M, Taga M, Chen P-L et al.
(
2008
)
.
Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37
.
Front Biosci
vol.
13
,
240
-
248
.
Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T
(
2006
)
.
ATM activation by ionizing radiation requires BRCA1-associated BAAT1
.
J Biol Chem
vol.
281
,
(
14
)
9710
-
9718
.
Martin SA, Ouchi T
(
2005
)
.
BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis
.
Cancer Res
vol.
65
,
(
23
)
10657
-
10662
.
Martin SA, Caplice NC, Davey GC, Powell R
(
2003
)
.
Identification of genes expressed in the liver of the Atlantic salmon (Salmo salar)
.
Marine Biotechnology : An Overview of Leading Field
.
Editors:
ColliecJouault, S
,
90
-
94
.
Martin SA, Caplice NC, Davey GC, Powell R
(
2002
)
.
EST-based identification of genes expressed in the liver of adult Atlantic salmon (Salmo salar)
.
Biochem Biophys Res Commun
vol.
293
,
(
1
)
578
-
585
.
Davey GC, Caplice NC, Martin SA, Powell R
(
2001
)
.
Erratum to: “A survey of genes in the Atlantic salmon (Salmo salar) as identified by expressed sequence tags” [Gene 263 (2001) 121–130]
.
Gene
vol.
269
,
(
1-2
)
Davey GC, Caplice NC, Martin SA, Powell R
(
2001
)
.
A survey of genes in the Atlantic salmon (Salmo salar) as identified by expressed sequence tags
.
Gene
vol.
263
,
(
1-2
)
121
-
130
.