Skip to main content
Research

Publications: Mr Rayomand Khambata

Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP et al. ( 2022 ) . Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide . British Journal of Pharmacology vol. 179 , ( 20 ) 4757 - 4777 .
Shabbir A, Rathod K, Primus C, Lau C, Chhetri I, Ono M, Khambata R, Massimo G et al. ( 2022 ) . BS37 Leukocytic nitrate reductase activity mitigates systemic inflammation-induced endothelial dysfunction in humans by accelerating resolution . Conference: Basic sciencea167.1 - a1a167 .
Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Montalvo Moreira SA, Rathod K, Chen J et al. ( 2022 ) . 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin . British Journal of Pharmacology vol. 179 , ( 7 ) 1450 - 1469 .
Primus C, Masucci M, Whitear C, Moreira SAM, Kumar NA, Chhetri I, Rathod KS, Khambata R et al. ( 2021 ) . A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate . European Heart Journal vol. 42 , ( Supplement_1 )
Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al. ( 2021 ) . Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers . European Heart Journal vol. 42 , ( Supplement_1 )
Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al. ( 2021 ) . Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers . EUROPEAN HEART JOURNAL . vol. 42 , 3009 - 3009 .
Shabbir A, Rathod KS, Khambata RS, Ahluwalia A ( 2021 ) . Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease . Annual Review of Pharmacology and Toxicology vol. 61 , 333 - 359 .
Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM, Ahluwalia A ( 2020 ) . The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway . Pharmacological reviews vol. 72 , ( 3 ) 692 - 766 .
( 2019 ) . Natural Mutations of the Human Xdh Impact upon the Nitric Oxide-generating Capacity of Xanthine Oxidoreductase . Free Radical Biology and Medicine . vol. 145 ,
Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, S. Watson D, Barnes MR et al. ( 2018 ) . Sex differences in the nitrate-nitrite-NO <sup>•</sup> pathway: Role of oral nitrate-reducing bacteria . Free Radical Biology and Medicine vol. 126 , 113 - 121 .
Yellon DM, He Z, Khambata R, Ahluwalia A, Davidson SM ( 2018 ) . The GTN patch: a simple and effective new approach to cardioprotection? . Basic Research in Cardiology vol. 113 , ( 3 )
Rathod KS, Hamshere S, Khambata RS, Andiapen M, Westwood M, Mathur A, Ahluwalia A, Jones DA ( 2017 ) . Combined analysis of the safety of intra-coronary drug delivery during primary percutaneous coronary intervention for acute myocardial infarction: A study of three clinical trials . JRSM Cardiovasc Dis vol. 6 , 2048004017725988 - 2048004017725988 .
Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, Gee L, Bansal J et al. ( 2017 ) . Sex differences in the inflammatory response and inflammation-induced vascular dysfunction . LANCET . Conference: FASEB vol. 389 , 20 - 20 .
AHLUWALIA A ( 2017 ) . The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque . Proceedings of the National Academy of Sciences of USA
AHLUWALIA A ( 2016 ) . Accelerated resolution underlies sex differences in the inflammatory response in human . Journal of Clinical Investigation vol. 127 , ( 1 ) 169 - 182 .
Jones DA, Khambata RS, Andiapen M, Rathod KS, Mathur A, Ahluwalia A ( 2016 ) . Intracoronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention . Heart
Khambata RS, Ghosh SM, Rathod KS, Thevathasan T, Ahluwalia A ( 2016 ) . Dietary Nitrate Supresses Leukocyte Recruitment and Activation in Apolipoprotein E Knockout Mice . FASEB JOURNAL . vol. 30 ,
Filomena F, Khambata R, Ahluwalia A ( 2016 ) . Dietary nitrate suppresses platelet reactivity in Apolipoprotein E Knockout Mice . FASEB JOURNAL . vol. 30 ,
Rathod KS, Siddiqui U, Hartley A, Khambata RS, Ahluwalia A ( 2016 ) . Investigation of the influence of sex on cantharidin-induced inflammation in healthy volunteers . FASEB JOURNAL . vol. 30 ,
Velmurugan S, Gan JM, Rathod KS, Khambata RS, Ghosh SM, Hartley A, Van Eijl S, Sagi-Kiss V et al. ( 2016 ) . Dietary nitrate improves vascular function in patients with hypercholesterolemia: A randomized, double-blind, placebo-controlled study . American Journal of Clinical Nutrition vol. 103 , ( 1 ) 25 - 38 .
Fernandes D, Khambata R, Ahluwalia A ( 2015 ) . Effects of Inorganic Nitrate on Endothelial Dysfunction Induced by Periodontitis . CIRCULATION . vol. 132 ,
Khambata RS, Ghosh SM, Ahluwalia A ( 2015 ) . "Repurposing" of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension . Antioxidants and Redox Signaling vol. 23 , ( 4 ) 340 - 353 .
Velmurugan S, Ghosh SM, Khambata RS, Van Eijl S, Robertson A, Chowdhury TA, Ahluwalia A ( 2015 ) . Acute administration of dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia . EUROPEAN HEART JOURNAL . vol. 36 , 257 - 257 .
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2015 ) . Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532)) . Free Radical Biology and Medicine vol. 84 ,
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2015 ) . Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study . Hypertension vol. 65 , ( 2 ) 320 - 327 .
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2015 ) . Erratum to "Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex" [Free Radic. Biol. Med. 65 (2013) 1521-1532] . Free Radical Biology and Medicine
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2014 ) . Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients: A Randomized, Phase 2, Double-Blind, Placebo-Controlled Study . Hypertension
Velmurugan S, Ghosh S, Khambata R, Van Eijl S, Robertson A, Chowdhury T, Ahluwalia A ( 2014 ) . Dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia . Nitric Oxide vol. 42C ,
Rathod K, Ghosh S, Khambata R, Ahluwalia A ( 2014 ) . Xanthine oxidoreductase in atherosclerotic mice: Determination of expression and nitrite reductase activity . Nitric Oxide vol. 42C ,
Velmurugan S, Ghosh SM, Khambata RS, Robertson AC, Van Eijl TJA, Chowdhury TA, Ahluwalia A ( 2014 ) . Dietary nitrate improves endothelial function, vascular stiffness and modifies platelet markers of atherogenesis in hypercholesterolemia . EUROPEAN HEART JOURNAL . vol. 35 , 1047 - 1047 .
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin Invest vol. 124 , ( 9 ) 4039 - 4051 .
Ghosh S, Khambata R, Ahluwalia A ( 2014 ) . DIETARY INORGANIC NITRATE REDUCES INFLAMMATORY CELL RECRUITMENT IN MICE . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 17 - 17 .
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2013 ) . Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex . Free Radic Biol Med vol. 65 , 1521 - 1532 .
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al. ( 2013 ) . Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential . Hypertension vol. 61 , ( 5 ) 1091 - 1102 .
Jones DA, Khambata RS, Mathur A, Ahluwalia A ( 2013 ) . P22 Sodium nitrite promotes the viability and proliferation of endothelial cells but inhibits the growth of smooth muscle cells under hypoxia . Nitric Oxide . vol. 31 ,
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2013 ) . Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex . Free Radical Biology and Medicine vol. 65 , 1521 - 1532 .
Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ ( 2012 ) . Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide . CIRCULATION vol. 126 , ( 21 )
Velmurugan S, Pearl V, Ghosh SM, Davies S, Khambata RS, van Eijl S, Kapil V, Ahluwalia A ( 2012 ) . Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP . CIRCULATION vol. 126 , ( 21 )
Bubb KJ, Khambata RS, Ahluwalia A ( 2012 ) . Sexual dimorphism in rodent models of hypertension and atherosclerosis . Br J Pharmacol vol. 167 , ( 2 ) 298 - 312 .
Khambata R, Ghosh S, Ahluwalia A ( 2012 ) . Nitrite superfusion reduces leukocyte-endothelial interactions in the mouse cremaster model . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 27 , S15 - S15 .
Khambata RS, Panayiotou CM, Hobbs AJ ( 2011 ) . Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide . Br J Pharmacol vol. 164 , ( 2b ) 584 - 597 .
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al. ( 2011 ) . Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin . Arterioscler Thromb Vasc Biol vol. 31 , ( 5 ) 1075 - 1083 .
Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target . CURRENT PHARMACEUTICAL DESIGN vol. 16 , ( 37 ) 4080 - 4088 .
Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ ( 2010 ) . The anti‐atherogenic potential of C‐type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor‐C . The FASEB Journal vol. 24 , ( S1 ) 573.4 - 573.4 .
Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target . Curr Pharm Des vol. 16 , ( 37 ) 4080 - 4088 .