Publications: Mr Rayomand Khambata
Fernandes D, Khambata RS, Massimo G, Ruivo E, Gee LC, Foster J, Goddard A, Curtis M et al.
(
2023
)
.
Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis
.
Pharmacological Research
vol.
188
,
Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP et al.
(
2022
)
.
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide
.
British Journal of Pharmacology
vol.
179
,
(
20
)
4757
-
4777
.
Shabbir A, Rathod K, Primus C, Lau C, Chhetri I, Ono M, Khambata R, Massimo G et al.
(
2022
)
.
BS37 Leukocytic nitrate reductase activity mitigates systemic inflammation-induced endothelial dysfunction in humans by accelerating resolution
.
Conference:
Basic sciencea167.1
-
a1a167
.
Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Montalvo Moreira SA, Rathod K, Chen J et al.
(
2022
)
.
20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin
.
British Journal of Pharmacology
vol.
179
,
(
7
)
1450
-
1469
.
Primus C, Masucci M, Whitear C, Moreira SAM, Kumar NA, Chhetri I, Rathod KS, Khambata R et al.
(
2021
)
.
A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate
.
European Heart Journal
vol.
42
,
(
Supplement_1
)
Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al.
(
2021
)
.
Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers
.
European Heart Journal
vol.
42
,
(
Supplement_1
)
Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al.
(
2021
)
.
Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers
.
EUROPEAN HEART JOURNAL
.
vol.
42
,
3009
-
3009
.
Shabbir A, Rathod KS, Khambata RS, Ahluwalia A
(
2021
)
.
Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease
.
Annual Review of Pharmacology and Toxicology
vol.
61
,
333
-
359
.
Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM, Ahluwalia A
(
2020
)
.
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway
.
Pharmacological reviews
vol.
72
,
(
3
)
692
-
766
.
(
2019
)
.
Natural Mutations of the Human Xdh Impact upon the Nitric Oxide-generating Capacity of Xanthine Oxidoreductase
.
Free Radical Biology and Medicine
.
vol.
145
,
Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, S. Watson D, Barnes MR et al.
(
2018
)
.
Sex differences in the nitrate-nitrite-NO <sup>•</sup> pathway: Role of oral nitrate-reducing bacteria
.
Free Radical Biology and Medicine
vol.
126
,
113
-
121
.
Yellon DM, He Z, Khambata R, Ahluwalia A, Davidson SM
(
2018
)
.
The GTN patch: a simple and effective new approach to cardioprotection?
.
Basic Research in Cardiology
vol.
113
,
(
3
)
Rathod KS, Hamshere S, Khambata RS, Andiapen M, Westwood M, Mathur A, Ahluwalia A, Jones DA
(
2017
)
.
Combined analysis of the safety of intra-coronary drug delivery during primary percutaneous coronary intervention for acute myocardial infarction: A study of three clinical trials
.
JRSM Cardiovasc Dis
vol.
6
,
2048004017725988
-
2048004017725988
.
Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, Gee L, Bansal J et al.
(
2017
)
.
Sex differences in the inflammatory response and inflammation-induced vascular dysfunction
.
LANCET
.
Conference:
FASEB
vol.
389
,
20
-
20
.
AHLUWALIA A
(
2017
)
.
The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque
.
Proceedings of the National Academy of Sciences of USA
AHLUWALIA A
(
2016
)
.
Accelerated resolution underlies sex differences in the inflammatory response in human
.
Journal of Clinical Investigation
vol.
127
,
(
1
)
169
-
182
.
Jones DA, Khambata RS, Andiapen M, Rathod KS, Mathur A, Ahluwalia A
(
2016
)
.
Intracoronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention
.
Heart
Khambata RS, Ghosh SM, Rathod KS, Thevathasan T, Ahluwalia A
(
2016
)
.
Dietary Nitrate Supresses Leukocyte Recruitment and Activation in Apolipoprotein E Knockout Mice
.
FASEB JOURNAL
.
vol.
30
,
Filomena F, Khambata R, Ahluwalia A
(
2016
)
.
Dietary nitrate suppresses platelet reactivity in Apolipoprotein E Knockout Mice
.
FASEB JOURNAL
.
vol.
30
,
Rathod KS, Siddiqui U, Hartley A, Khambata RS, Ahluwalia A
(
2016
)
.
Investigation of the influence of sex on cantharidin-induced inflammation in healthy volunteers
.
FASEB JOURNAL
.
vol.
30
,
Velmurugan S, Gan JM, Rathod KS, Khambata RS, Ghosh SM, Hartley A, Van Eijl S, Sagi-Kiss V et al.
(
2016
)
.
Dietary nitrate improves vascular function in patients with hypercholesterolemia: A randomized, double-blind, placebo-controlled study
.
American Journal of Clinical Nutrition
vol.
103
,
(
1
)
25
-
38
.
Fernandes D, Khambata R, Ahluwalia A
(
2015
)
.
Effects of Inorganic Nitrate on Endothelial Dysfunction Induced by Periodontitis
.
CIRCULATION
.
vol.
132
,
Khambata RS, Ghosh SM, Ahluwalia A
(
2015
)
.
"Repurposing" of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension
.
Antioxidants and Redox Signaling
vol.
23
,
(
4
)
340
-
353
.
Velmurugan S, Ghosh SM, Khambata RS, Van Eijl S, Robertson A, Chowdhury TA, Ahluwalia A
(
2015
)
.
Acute administration of dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia
.
EUROPEAN HEART JOURNAL
.
vol.
36
,
257
-
257
.
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al.
(
2015
)
.
Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532))
.
Free Radical Biology and Medicine
vol.
84
,
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A
(
2015
)
.
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study
.
Hypertension
vol.
65
,
(
2
)
320
-
327
.
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al.
(
2015
)
.
Erratum to "Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex" [Free Radic. Biol. Med. 65 (2013) 1521-1532]
.
Free Radical Biology and Medicine
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A
(
2014
)
.
Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients: A Randomized, Phase 2, Double-Blind, Placebo-Controlled Study
.
Hypertension
Velmurugan S, Ghosh S, Khambata R, Van Eijl S, Robertson A, Chowdhury T, Ahluwalia A
(
2014
)
.
Dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia
.
Nitric Oxide
vol.
42C
,
Rathod K, Ghosh S, Khambata R, Ahluwalia A
(
2014
)
.
Xanthine oxidoreductase in atherosclerotic mice: Determination of expression and nitrite reductase activity
.
Nitric Oxide
vol.
42C
,
Velmurugan S, Ghosh SM, Khambata RS, Robertson AC, Van Eijl TJA, Chowdhury TA, Ahluwalia A
(
2014
)
.
Dietary nitrate improves endothelial function, vascular stiffness and modifies platelet markers of atherogenesis in hypercholesterolemia
.
EUROPEAN HEART JOURNAL
.
vol.
35
,
1047
-
1047
.
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al.
(
2014
)
.
Endothelial C-type natriuretic peptide maintains vascular homeostasis
.
J Clin Invest
vol.
124
,
(
9
)
4039
-
4051
.
Ghosh S, Khambata R, Ahluwalia A
(
2014
)
.
DIETARY INORGANIC NITRATE REDUCES INFLAMMATORY CELL RECRUITMENT IN MICE
.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
.
vol.
115
,
17
-
17
.
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al.
(
2013
)
.
Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex
.
Free Radic Biol Med
vol.
65
,
1521
-
1532
.
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al.
(
2013
)
.
Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential
.
Hypertension
vol.
61
,
(
5
)
1091
-
1102
.
Jones DA, Khambata RS, Mathur A, Ahluwalia A
(
2013
)
.
P22 Sodium nitrite promotes the viability and proliferation of endothelial cells but inhibits the growth of smooth muscle cells under hypoxia
.
Nitric Oxide
.
vol.
31
,
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al.
(
2013
)
.
Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex
.
Free Radical Biology and Medicine
vol.
65
,
1521
-
1532
.
Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ
(
2012
)
.
Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide
.
CIRCULATION
vol.
126
,
(
21
)
Velmurugan S, Pearl V, Ghosh SM, Davies S, Khambata RS, van Eijl S, Kapil V, Ahluwalia A
(
2012
)
.
Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP
.
CIRCULATION
vol.
126
,
(
21
)
Bubb KJ, Khambata RS, Ahluwalia A
(
2012
)
.
Sexual dimorphism in rodent models of hypertension and atherosclerosis
.
Br J Pharmacol
vol.
167
,
(
2
)
298
-
312
.
Khambata R, Ghosh S, Ahluwalia A
(
2012
)
.
Nitrite superfusion reduces leukocyte-endothelial interactions in the mouse cremaster model
.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
.
vol.
27
,
S15
-
S15
.
Khambata RS, Panayiotou CM, Hobbs AJ
(
2011
)
.
Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide
.
Br J Pharmacol
vol.
164
,
(
2b
)
584
-
597
.
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al.
(
2011
)
.
Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin
.
Arterioscler Thromb Vasc Biol
vol.
31
,
(
5
)
1075
-
1083
.
Lumsden NG, Khambata RS, Hobbs AJ
(
2010
)
.
C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target
.
CURRENT PHARMACEUTICAL DESIGN
vol.
16
,
(
37
)
4080
-
4088
.
Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ
(
2010
)
.
The anti‐atherogenic potential of C‐type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor‐C
.
The FASEB Journal
vol.
24
,
(
S1
)
573.4
-
573.4
.
Lumsden NG, Khambata RS, Hobbs AJ
(
2010
)
.
C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target
.
Curr Pharm Des
vol.
16
,
(
37
)
4080
-
4088
.