Publications: Mr Rayomand Khambata

Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod K et al. ( 2023 ) . Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864] . Redox Biology vol. 67 ,

Shabbir A, Chhetri I, Khambata RS, Parakaw T, Lau C, Aubdool MABN, Massimo G, Dyson N et al. ( 2023 ) . A double-blind, randomised, placebo-controlled parallel study to investigate the effect of sex and dietary nitrate on COVID-19 vaccine-induced vascular dysfunction in healthy men and women: protocol of the DiNOVasc-COVID-19 study . Trials vol. 24 , ( 1 )

Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod KS et al. ( 2023 ) . Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? . Redox Biology vol. 67 ,

Rathod K, Warren H, Tufaro V, Jain A, Ono M, Chhetri I, Garcia-Garcia H, Bourantas C et al. ( 2023 ) . 34 Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (nitrate-oct study) . Conference: Acute coronary syndromes & Interventional Cardiologya37 - a38 .

Rathod KS, Shabbir A, Jones DA, Khambata RS, Lau C, Beirne A-M, Ono M, Chhetri I et al. ( 2023 ) . D Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (NITRATE-OCT study) . Conference: Young investigators awarda314 - a315 .

Bosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale TD et al. ( 2023 ) . Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow . Science Signaling vol. 16 , ( 786 )

Rathod KS, Kapil V, Velmurugan S, Khambata RS, Siddique U, Khan S, Van Eijl S, Gee LC et al. ( 2023 ) . Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans . Journal of Clinical Investigation vol. 133 , ( 2 )

Rathod KS, Shabbir A, Khambata R, Lau C, Beirne A-M, Chhetri I, Ono M, Belgaid D et al. ( 2023 ) . Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in stable angina (NITRATE-OCT Sub-Study) . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 221 - 222 .

Khambata R, Fernandes D, Massimo G, Ruivo E, Gee LC, Foster J, Goddard A, Curtis M et al. ( 2023 ) . Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 15 - 16 .

Massimo G, Khambata R, Chapman T, Birchall K, Borghi C, Ahluwalia A ( 2023 ) . Natural Mutations Of Human Xdh Promote The Nitirte (No2-)-Reductase Capacity Of Xanthine Oxidoreductase: A Novel Mechanism To Promote Redox Health? . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 51 - 52 .

Dyson N, Khambata R, Massimo G, Parakaw T, Rathod K, Ahluwalia A ( 2023 ) . Nitrite reductase activity of liver-derived Xanthine Oxidoreductase maintains cardiovascular homeostasis . BRITISH JOURNAL OF PHARMACOLOGY . vol. 180 , 186 - 187 .

Fernandes D, Khambata RS, Massimo G, Ruivo E, Gee LC, Foster J, Goddard A, Curtis M et al. ( 2022 ) . Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis . Pharmacological Research vol. 188 ,

Shabbir A, Rathod K, Primus C, Lau C, Chhetri I, Ono M, Khambata R, Massimo G et al. ( 2022 ) . BS37 Leukocytic nitrate reductase activity mitigates systemic inflammation-induced endothelial dysfunction in humans by accelerating resolution . Conference: Basic sciencea167.1 - a1a167 .

Hamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Moreira SAM, Rathod K, Chen J et al. ( 2022 ) . 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin . British Journal of Pharmacology vol. 179 , ( 7 ) 1450 - 1469 .

Primus C, Masucci M, Whitear C, Moreira SAM, Kumar NA, Chhetri I, Rathod KS, Khambata R et al. ( 2021 ) . A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate . European Heart Journal vol. 42 , ( Supplement_1 )

Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al. ( 2021 ) . Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers . European Heart Journal vol. 42 , ( Supplement_1 )

Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP et al. ( 2021 ) . Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide . British Journal of Pharmacology vol. 179 , ( 20 ) 4757 - 4777 .

Shabbir A, Lau C, Rathod KS, Chhetri I, Haque A, Godec T, Khambata RS, Kapil V et al. ( 2021 ) . Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers . EUROPEAN HEART JOURNAL . vol. 42 , 3009 - 3009 .

Shabbir A, Rathod KS, Khambata RS, Ahluwalia A ( 2020 ) . Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease . The Annual Review of Pharmacology and Toxicology vol. 61 , ( 1 ) 1 - 27 .

Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM, Ahluwalia A ( 2020 ) . The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway . Pharmacological reviews vol. 72 , ( 3 ) 692 - 766 .

( 2019 ) . Natural Mutations of the Human Xdh Impact upon the Nitric Oxide-generating Capacity of Xanthine Oxidoreductase . Free Radical Biology and Medicine . vol. 145 ,

Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, Watson DS, Barnes MR et al. ( 2018 ) . Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria . Free Radical Biology and Medicine vol. 126 , 113 - 121 .

Yellon DM, He Z, Khambata R, Ahluwalia A, Davidson SM ( 2018 ) . The GTN patch: a simple and effective new approach to cardioprotection? . Basic Research in Cardiology vol. 113 , ( 3 )

Rathod KS, Hamshere S, Khambata RS, Andiapen M, Westwood M, Mathur A, Ahluwalia A, Jones DA ( 2017 ) . Combined analysis of the safety of intra-coronary drug delivery during primary percutaneous coronary intervention for acute myocardial infarction: A study of three clinical trials . JRSM Cardiovasc Dis vol. 6 , 2048004017725988 - 2048004017725988 .

Rathod K, Kapil V, Velmurugan S, Khambata R, Siddique U, Khan S, Gee L, Bansal J et al. ( 2017 ) . Sex differences in the inflammatory response and inflammation-induced vascular dysfunction . LANCET . Conference: FASEB vol. 389 , 20 - 20 .

AHLUWALIA A ( 2017 ) . The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque . Proceedings of the National Academy of Sciences of USA

AHLUWALIA A ( 2016 ) . Accelerated resolution underlies sex differences in the inflammatory response in human . Journal of Clinical Investigation vol. 127 , ( 1 ) 169 - 182 .

Jones DA, Khambata RS, Andiapen M, Rathod KS, Mathur A, Ahluwalia A ( 2016 ) . Intracoronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention . Heart

Khambata RS, Ghosh SM, Rathod KS, Thevathasan T, Ahluwalia A ( 2016 ) . Dietary Nitrate Supresses Leukocyte Recruitment and Activation in Apolipoprotein E Knockout Mice . The FASEB Journal . vol. 30 ,

Filomena F, Khambata R, Ahluwalia A ( 2016 ) . Dietary nitrate suppresses platelet reactivity in Apolipoprotein E Knockout Mice . The FASEB Journal . vol. 30 ,

Rathod KS, Siddiqui U, Hartley A, Khambata RS, Ahluwalia A ( 2016 ) . Investigation of the influence of sex on cantharidin‐induced inflammation in healthy volunteers . The FASEB Journal . vol. 30 ,

Velmurugan S, Gan JM, Rathod KS, Khambata RS, Ghosh SM, Hartley A, Van Eijl S, Sagi-Kiss V et al. ( 2015 ) . Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study 1–3 . American Journal of Clinical Nutrition vol. 103 , ( 1 ) 25 - 38 .

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2015 ) . Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532)) . Free Radical Biology and Medicine vol. 84 ,

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2015 ) . Erratum to “Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex” [Free Radic. Biol. Med. 65 (2013) 1521–1532] . Free Radical Biology and Medicine vol. 84 ,

Khambata RS, Ghosh SM, Ahluwalia A ( 2015 ) . “Repurposing” of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension . Antioxidants & Redox Signaling vol. 23 , ( 4 ) 340 - 353 .

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2015 ) . Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study . Hypertension vol. 65 , ( 2 ) 320 - 327 .

Velmurugan S, Ghosh SM, Khambata RS, Van Eijl S, Robertson A, Chowdhury TA, Ahluwalia A ( 2015 ) . Acute administration of dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia . EUROPEAN HEART JOURNAL . vol. 36 , 257 - 257 .

Fernandes D, Khambata R, Ahluwalia A ( 2015 ) . Effects of Inorganic Nitrate on Endothelial Dysfunction Induced by Periodontitis . CIRCULATION . vol. 132 ,

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A ( 2014 ) . Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients . Hypertension vol. 65 , ( 2 ) 320 - 327 .

Rathod K, Ghosh S, Khambata R, Ahluwalia A ( 2014 ) . P175 Xanthine oxidoreductase in atherosclerotic mice: Determination of expression and nitrite reductase activity . Nitric Oxide vol. 42 ,

Velmurugan S, Ghosh S, Khambata R, Van Eijl S, Robertson A, Chowdhury T, Ahluwalia A ( 2014 ) . P200 Dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia . Nitric Oxide vol. 42 ,

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ et al. ( 2014 ) . Endothelial C-type natriuretic peptide maintains vascular homeostasis . J Clin Invest vol. 124 , ( 9 ) 4039 - 4051 .

Ghosh S, Khambata R, Ahluwalia A ( 2014 ) . DIETARY INORGANIC NITRATE REDUCES INFLAMMATORY CELL RECRUITMENT IN MICE . BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY . vol. 115 , 17 - 17 .

Velmurugan S, Ghosh SM, Khambata RS, Robertson AC, Van Eijl TJA, Chowdhury TA, Ahluwalia A ( 2014 ) . Dietary nitrate improves endothelial function, vascular stiffness and modifies platelet markers of atherogenesis in hypercholesterolemia . EUROPEAN HEART JOURNAL . vol. 35 , 1047 - 1047 .

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2013 ) . Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex . Free Radic Biol Med vol. 65 , 1521 - 1532 .

Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S et al. ( 2013 ) . Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential . Hypertension vol. 61 , ( 5 ) 1091 - 1102 .

Jones DA, Khambata RS, Mathur A, Ahluwalia A ( 2013 ) . P22 Sodium nitrite promotes the viability and proliferation of endothelial cells but inhibits the growth of smooth muscle cells under hypoxia . Nitric Oxide . vol. 31 ,

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ et al. ( 2013 ) . Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex . Free Radical Biology and Medicine vol. 65 , 1521 - 1532 .

Bubb KJ, Khambata RS, Ahluwalia A ( 2012 ) . Sexual dimorphism in rodent models of hypertension and atherosclerosis . Br J Pharmacol vol. 167 , ( 2 ) 298 - 312 .

Moyes AJ, Khambata RS, Ahluwalia A, Hobbs AJ ( 2012 ) . Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide . CIRCULATION vol. 126 , ( 21 )

Velmurugan S, Pearl V, Ghosh SM, Davies S, Khambata RS, van Eijl S, Kapil V, Ahluwalia A ( 2012 ) . Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP . CIRCULATION vol. 126 , ( 21 )

Khambata R, Ghosh S, Ahluwalia A ( 2012 ) . Nitrite superfusion reduces leukocyte-endothelial interactions in the mouse cremaster model . NITRIC OXIDE-BIOLOGY AND CHEMISTRY . vol. 27 , S15 - S15 .

Khambata RS, Panayiotou CM, Hobbs AJ ( 2011 ) . Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide . Br J Pharmacol vol. 164 , ( 2b ) 584 - 597 .

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ et al. ( 2011 ) . Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin . Arterioscler Thromb Vasc Biol vol. 31 , ( 5 ) 1075 - 1083 .

Khambata RS, Panayiotou CM, Xiao F, Hobbs AJ ( 2010 ) . The anti‐atherogenic potential of C‐type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor‐C . The FASEB Journal vol. 24 , ( S1 ) 573.4 - 573.4 .

Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target . CURRENT PHARMACEUTICAL DESIGN vol. 16 , ( 37 ) 4080 - 4088 .

Lumsden NG, Khambata RS, Hobbs AJ ( 2010 ) . C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target . Curr Pharm Des vol. 16 , ( 37 ) 4080 - 4088 .