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Research

Publications: Dr Jun Wang

Thomson J, Bewicke-Copley F, Anene CA, Gulati A, Nagano A, Purdie K, Inman GJ, Proby CM et al. ( 2021 ) . THE GENOMIC LANDSCAPE OF ACTINIC KERATOSIS . J Invest Dermatol
Keane L, Antignano I, Riechers SP, Zollinger R, Dumas AA, Offermann N, Bernis ME, Russ J et al. ( 2021 ) . mTOR-dependent translation amplifies microglia priming in aging mice . Journal of Clinical Investigation vol. 131 , ( 1 )
Marzec J, Ross-Adams H, Pirrò S, Wang J, Zhu Y, Mao X, Gadaleta E, Ahmad AS et al. ( 2021 ) . The transcriptomic landscape of prostate cancer development and progression: An integrative analysis . Cancers vol. 13 , ( 2 ) 1 - 24 .
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N et al. ( 2020 ) . The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants . Nature Communications vol. 11 , ( 1 )
Rio-Machin A, Casado-Izquierdo P, Miettinen J, Bewicke-Copley F, Khan N, Demeulemeester J, Krizsán S, Zheng J et al. ( 2020 ) . Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia . Blood vol. 136 , ( Supplement 1 ) 39 - 40 .
Larrea E, Fernandez¿mercado M, Guerra¿assunção JA, Wang J, Goicoechea I, Gaafar A, Ceberio I, Lobo C et al. ( 2020 ) . Identification of recurrent mutations in the microrna‐binding sites of b‐cell lymphoma‐ associated genes in follicular lymphoma . International Journal of Molecular Sciences vol. 21 , ( 22 ) 1 - 12 .
Mcclelland S, Tamura N, Shaikh N, Muliaditan D, Soliman T, McGuinness J, Maniati E, Moralli D et al. ( 2020 ) . Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma . Cancer Research
Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR et al. ( 2020 ) . Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer . npj Breast Cancer vol. 6 , ( 1 )
Iacovazzo D, Thong LC, Quezado R, Drummond J, Antonio DSBF, Cuenco J, Brändle M, Walker E et al. ( 2020 ) . The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators . Endocrine Abstracts
Dokal I, Tummala H, Vulliamy T, Walne A ( 2020 ) . A frameshift variant in the specificity protein 1 triggers superactivation of SP1-mediated transcription in familial bone marrow failure . Proceedings of the National Academy of Sciences of USA Article 32636268 ,
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance . a31 - a31 .
Araf S, Korfi K, Bewicke-Copley F, Wang J, Cogliatti S, Kumar E, Forrer F, Barrington SF et al. ( 2020 ) . Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma . Haematologica vol. 105 , ( 6 ) E318 - E321 .
Gomez-Escudero J, Maniati E, Whiting F, Wang J, Graham T, Hodivala-Dilke K ( 2020 ) . Tumor stroma in the development of acquired cancer therapy resistance . CANCER RESEARCH . vol. 80 , 48 - 48 .
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al. ( 2020 ) . Cancer associated fibroblast FAK regulates malignant cell metabolism . Nature Communications vol. 11 , ( 1 ) 1290 - 1290 .
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Zhang Z et al. ( 2020 ) . A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer . Clinical Cancer Research vol. 26 , ( 2 ) 465 - 476 .
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J et al. ( 2019 ) . Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease . Journal of Pathology vol. 249 , ( 4 ) 523 - 535 .
Bewicke-Copley F, Korfi K, Araf S, Kumar EA, Cummin TEC, Ashton-Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel . Blood vol. 134 , ( Supplement_1 ) 2769 - 2769 .
Martin S ( 2019 ) . MLH1 deficiency leads to deregulated mitochondrial metabolism . Cell Death and Disease vol. 10 , 795 - 795 .
Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al. ( 2019 ) . 423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer . Journal of Investigative Dermatology . vol. 139 ,
Robinson DJ, Patel A, Purdie KJ, Wang J, Rizvi H, Hufbauer M, Ostano P, Akgül B et al. ( 2019 ) . Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma . Journal of Investigative Dermatology vol. 139 , ( 8 ) 1658 - 1671.e8 .
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al. ( 2019 ) . A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing . International Journal of Molecular Sciences vol. 20 , ( 14 )
Korfi K, Araf S, Bewicke¿Copley F, Kumar E, Cummin T, Ashton¿Key M, Barrans S, Van Hoppe S et al. ( 2019 ) . LONGITUDINAL ANALYSES OF DIAGNOSTIC‐RELAPSE BIOPSIES OF DIFFUSE LARGE B CELL LYMPHOMA SUGGEST THAT RELAPSE IS MEDIATED BY DISTINCT MECHANISMS IN ABC AND GCB LYMPHOMA . Hematological Oncology vol. 37 , 142 - 143 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2019 ) . Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y) . Leukemia vol. 33 , ( 6 )
Kumar E, Korfi K, Bewicke-Copley F, Witzig T, Leukam M, Ansell S, Scott J, Rallis K et al. ( 2019 ) . MUTATIONS AFFECTING THE CREBBP HAT DOMAIN PREDICT RESPONSE TO MTOR INHIBITORS EVEROLIMUS AND TEMSIROLIMUS IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA . HemaSphere vol. 3 ,
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . Journal of Investigative Dermatology vol. 139 , ( 5 )
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al. ( 2019 ) . iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus . JOURNAL OF INVESTIGATIVE DERMATOLOGY . vol. 139 , S78 - S78 .
Araf S, Wang J, Ashton-Key M, Korfi K, Di Bella D, Rio-Machin A, Odabashian M, Foria V et al. ( 2019 ) . Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant . Haematologica vol. 104 , ( 4 ) e174 - e177 .
Bewicke-Copley F, Arjun Kumar E, Palladino G, Korfi K, Wang J ( 2019 ) . Applications and analysis of targeted genomic sequencing in cancer studies . Computational and Structural Biotechnology Journal vol. 17 , 1348 - 1359 .
Brown P, Zhou Y, Tan AC, El-Esawi MA, Liehr T, Blanck O, Gladue DP, Almeida GMF et al. ( 2019 ) . Large expert-curated database for benchmarking document similarity detection in biomedical literature search . Database vol. 2019 , 1 - 67 .
Patel MB, Wang J ( 2019 ) . The identification and interpretation of cis-regulatory noncoding mutations in cancer . High-Throughput vol. 8 , ( 1 )
Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA et al. ( 2018 ) . MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma . Scientific Reports vol. 8 , ( 1 )
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J et al. ( 2018 ) . The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature . Nature Communications vol. 9 , ( 1 )
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR, Chelala C ( 2018 ) . SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine . Nucleic Acids Research vol. 46 , ( W1 ) W109 - W113 .
Thomson J, Proby C, Leigh I, Nagano A, Harwood C, Inmann G, Wang J ( 2018 ) . Exome sequencing of a cohort of actinic keratoses to identify significantly mutated genes . BRITISH JOURNAL OF DERMATOLOGY . vol. 178 , E400 - E400 .
Wang J, Dayem Ullah AZ, Chelala C ( 2018 ) . IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome . Nucleic acids research vol. 46 , ( 8 )
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A et al. ( 2018 ) . CSF1R<sup>+</sup> Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype . Cell Reports vol. 23 , ( 5 ) 1448 - 1460 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J et al. ( 2018 ) . Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma . Leukemia vol. 32 , ( 5 ) 1258 - 1263 .
Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S et al. ( 2018 ) . GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML . Leukemia vol. 32 , ( 11 ) 2502 - 2507 .
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y et al. ( 2018 ) . PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer . Cell Reports vol. 22 , ( 9 ) 2469 - 2481 .
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward JA et al. ( 2017 ) . Genomic Profiling Reveals Spatial Intra-Tumor Heterogeneity in Follicular Lymphoma . BLOOD . vol. 130 ,
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al. ( 2017 ) . Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers . Cancer Discov
Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R et al. ( 2017 ) . Splice variants as novel targets in pancreatic ductal adenocarcinoma . Scientific Reports vol. 7 , ( 1 )
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J et al. ( 2017 ) . Lamin B1 regulates somatic mutations and progression of B-cell malignancies . Leukemia vol. 32 , ( 2 ) 364 - 375 .
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR et al. ( 2017 ) . 'Multi-omic' data analysis using O-miner . Brief Bioinform
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A et al. ( 2017 ) . Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree . European Journal of Human Genetics vol. 25 , ( 8 ) 1020 - 1024 .
Balkwill FR, Pearce OM, Delaine-Smith R, Maniati E, Nichols S, Wang J, Bessant C, Knight M ( 2017 ) . Abstract 5558: Deconstruction of a human tumor microenvironment . 5558 - 5558 .
Harwood C, Proby C, Wang J, Nagano A, Alexandrov L, Purdie K, Chelala C, Inman G et al. ( 2017 ) . Chronic azathioprine treatment is causal in cutaneous squamous cell carcinoma development and is associated with a novel mutational signature . BRITISH JOURNAL OF DERMATOLOGY . vol. 177 , 9 - 10 .
Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Wang J, Fischer K, Akylzhanova G, Edelmann J et al. ( 2017 ) . NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES . HAEMATOLOGICA . vol. 102 , 228 - 228 .
Ironside A, Hawkesford K, Gomm J, Haywood L, Goulding I, Wang J, Lamaziere A, Poirot M et al. ( 2017 ) . Molecular mediators of mammographic density . CANCER RESEARCH . Conference: 2016 San Antonio Breast Cancer Symposium from: 06/12/2016 to: 10/12/2016 , vol. 77 ,
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J et al. ( 2016 ) . Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia . LEUKEMIA vol. 30 , ( 11 ) 2179 - 2186 .
Proby CM, Inman G, Wang JA, Nagano A, Purdie KJ, Gulati A, Lambert S, Mladkova N et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma and Identification of a novel mutational signature associated with chronic azathioprine exposure . BRITISH JOURNAL OF DERMATOLOGY . vol. 175 , 58 - 59 .
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D et al. ( 2016 ) . Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma . Nature Communications vol. 7 , 12493 - 12493 .
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J et al. ( 2016 ) . Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1 . Cell Reports vol. 16 , ( 6 ) 1604 - 1613 .
Proby C, Inman G, Wang J, Nagano A, Purdie K, Mladkova N, Lambert S, Gulati A et al. ( 2016 ) . Characterisation of the molecular landscape of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E69 - E69 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Libertini S, Ridgway R, Mchugh A et al. ( 2016 ) . Frequent loss of function mutations in TGF beta R1 and TGF beta R2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma . MELANOMA RESEARCH . vol. 26 , E63 - E64 .
Inman G, Proby CM, Wang JA, Nagano A, Alexandrov L, Purdie K, Rose A, Weir L et al. ( 2016 ) . Identification of a novel mutational signature in cutaneous SCC associated with chronic azathioprine exposure . MELANOMA RESEARCH . vol. 26 , E114 - E115 .
GROSE RP, Dawkins JBN, Wang J, maniati, heward, koniali, kocher, martin et al. ( 2016 ) . Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma . Cancer Research
Araf S, Wang J, Pangault C, Kotsiou E, Hoxha E, Iqbal S, Davies J, Johnson P et al. ( 2016 ) . GENOMIC PROFILING REVEALS SPATIAL HETEROGENEITY IN FOLLICULAR LYMPHOMA: IMPLICATIONS FOR PRECISION MEDICINE . HAEMATOLOGICA . vol. 101 , 270 - 270 .
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H et al. ( 2016 ) . Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease . Leukemia vol. 30 , ( 6 ) 1301 - 1310 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016) . NATURE GENETICS vol. 48 , ( 6 ) 700 - 700 .
Rio-Machin A, Cardoso S, Tawana K, Wang J, Chelala C, Plagnol V, Wallis Y, Ryan G et al. ( 2016 ) . WHOLE EXOME SEQUENCING REVEALS NOVEL CANDIDATE GENES IN FAMILIAL MDS/AML . HAEMATOLOGICA . vol. 101 , 205 - 206 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA et al. ( 2016 ) . Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nat Genet vol. 48 , ( 6 ) 700 - 700 .
Cammareri P, Rose A, Vincent D, Wang J, Nagano A, Coates P, Sapkota G, Purdie K et al. ( 2016 ) . Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E51 - E52 .
Proby C, Inman G, Nagano A, Purdie K, Mladkova N, Alexandrov L, Stratton M, Watt S et al. ( 2016 ) . The molecular landscape of cutaneous squamous cell carcinoma . BRITISH JOURNAL OF DERMATOLOGY . vol. 174 , E50 - E51 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2016 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics vol. 48 , ( 2 ) 183 - 188 .
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF et al. ( 2015 ) . Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma . Nature Genetics .
Rose-Zerilli MJJ, Parker H, Larrayoz M, Clifford R, Blakemore S, Edelmann J, Gibson J, Wang J et al. ( 2015 ) . Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia . Blood vol. 126 , ( 23 ) 365 - 365 .
Parry M, Rose-Zerilli MJJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al. ( 2015 ) . Genetics and prognostication in splenic marginal zone lymphoma: Revelations from deep sequencing . Clinical Cancer Research vol. 21 , ( 18 ) 4174 - 4183 .
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW et al. ( 2015 ) . Disease evolution and outcomes in familial AML with germline CEBPA mutations . Blood vol. 126 , ( 10 ) 1214 - 1223 .
Tawana K, Wang J, Kiraly PA, Kallay K, Benyo G, Krivan G, Csomor J, Fitzgibbon J et al. ( 2015 ) . CONVERGENCE OF SOMATIC MUTATIONS WITHIN THE JAK-STAT SIGNALLING PATHWAY IN A NOVEL RUNX1-MUTATED PEDIGREE . HAEMATOLOGICA . vol. 100 , 9 - 10 .
Koniali L, Heward J, Loveday C, Wilkins L, Ishfaq M, Wang J, Okosun J, Packham G et al. ( 2015 ) . KDM5 INHIBITION LEADS TO INCREASED H3K4ME3 LEVELS AND CELL DEATH IN GERMINAL CENTRE LYMPHOMA CELL LINES INDEPENDENT OF MLL2 MUTATION STATUS . HAEMATOLOGICA . vol. 100 , 104 - 104 .
Nagano A, Purdie K, Pourreyron C, McHugh A, Xue D, Wright S, Dayal J, Watt S et al. ( 2015 ) . Cutaneous squamous cell carcinoma cell lines retain the genetic signature of human cutaneous squamous cell carcinoma and recapitulate the histology of the original human tumour in mouse xenograft models . BRITISH JOURNAL OF DERMATOLOGY . vol. 172 , E43 - E44 .
Yuan M, Zhang W, Wang J, Al Yaghchi C, Ahmed J, Chard L, Lemoine NR, Wang Y ( 2015 ) . Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system . Journal of Virology vol. 89 , ( 9 ) 5176 - 5179 .
Rose-Zerilli MJ, Parry M, Ljungstrom V, Gibson J, Wang J, Walewska R, Parker H, Parker A et al. ( 2014 ) . Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications . Blood . vol. 124 , 76 - 76 .
Rose-Zerilli MJ, Jane G, Wang J, Tapper WJ, Parker H, Parker A, Davis Z, Gardiner AC et al. ( 2014 ) . Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease . Blood . vol. 124 , 1962 - 1962 .
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al. ( 2014 ) . A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma . Genome Medicine vol. 6 , ( 12 )
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. ( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukaemia . BRITISH JOURNAL OF HAEMATOLOGY . vol. 165 , 16 - 16 .
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. ( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia . Blood vol. 123 , ( 13 ) 2066 - 2074 .
Okosun J, Bödör C, Wang J, Araf S, Yang CY, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nature Genetics vol. 46 , ( 2 ) 176 - 181 .
Okosun J, Bödör C, Wang J, Araf S, Yang C-Y, Pan C, Boller S, Cittaro D et al. ( 2014 ) . Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma . Nat Genet vol. 46 , ( 2 ) 176 - 181 .
Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW et al. ( 2013 ) . Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing . Blood . vol. 122 , 740 - 740 .
Manodoro F, Marzec J, Wang J, Chaplin T, Jovanovic JV, Eva M, Sameena I, Grimwade D et al. ( 2013 ) . Loss of Imprinting at the 14q32 Domain Leads to MicroRNA Overexpression in Acute Promyelocytic Leukemia . Blood . vol. 122 , 2494 - 2494 .
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al. ( 2013 ) . Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma . Gastroenterology vol. 145 , ( 5 ) 1121 - 1132 .
Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S et al. ( 2013 ) . EZH2 mutations are frequent and represent an early event in follicular lymphoma . Blood vol. 122 , ( 18 ) 3165 - 3168 .
Okosun J, Bödör C, Wang J, Araf S, Chelala C, Fitzgibbon J ( 2013 ) . Genomic analysis reveals epigenetic ‘addiction’ underpinning follicular lymphoma and its transformation – a rationale for targeted epigenetic therapies . Clinical Epigenetics vol. 5 , ( Suppl 1 )
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M et al. ( 2013 ) . Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes . J Pathol vol. 230 , ( 1 ) 107 - 117 .
Okosun J, Boedoer C, Wang J, Araf S, Marzec J, Iqbal S, Matthews J, Calaminici M et al. ( 2012 ) . Whole Genome Sequencing in Sequential Biopsies Reveals the Genetic Evolution of Follicular Lymphoma to Transformed Follicular Lymphoma . BLOOD . vol. 120 ,
Gilks WR, Welham SJ, Wang J, Clark SJ, King GJ ( 2012 ) . Three-point appraisal of genetic linkage maps . THEORETICAL AND APPLIED GENETICS vol. 125 , ( 7 ) 1393 - 1402 .
Manodoro F, Marzec J, Wang J, Chaplin T, Young B, Debernardi S ( 2012 ) . DEEP SEQUENCING REVEALS ALLELE-SPECIFIC HYPERMETHYLATION AT 14Q32 IMPRINTED DOMAIN IN ACUTE PROMYELOCITIC LEUKAEMIA (APML) . HAEMATOLOGICA . vol. 97 , 14 - 14 .
Kadaba R, Birke H, DiMaggio F, Wang J, Chelala C, Sasieni P, Kocher HM ( 2012 ) . Abstract B100: The proportion of pancreatic stellate cells plays a critical role in modulating pancreatic cancer cell behavior . b100 - b100 .
Love CG, Andongabo AE, Wang J, Carion PWC, Rawlings CJ, King GJ ( 2012 ) . InterStoreDB: a generic integration resource for genetic and genomic data . J Integr Plant Biol vol. 54 , ( 5 ) 345 - 355 .
Wang X, Wang H, Wang J, Sun R, Wu J, Liu S, Bai Y, Mun JH et al. ( 2011 ) . The genome of the mesopolyploid crop species Brassica rapa . Nature Genetics vol. 43 , ( 10 ) 1035 - 1040 .
Hammond JP, Mayes S, Bowen HC, Graham NS, Hayden RM, Love CG, Spracklen WP, Wang J et al. ( 2011 ) . Regulatory Hotspots Are Associated with Plant Gene Expression under Varying Soil Phosphorus Supply in Brassica rapa . PLANT PHYSIOL vol. 156 , ( 3 ) 1230 - 1241 .
Wang J, Lydiate DJ, Parkin IAP, Falentin C, Delourme R, Carion PWC, King GJ ( 2011 ) . Integration of linkage maps for the Amphidiploid Brassica napus and comparative mapping with Arabidopsis and Brassica rapa . BMC GENOMICS vol. 12 , Article 101 ,
Wang J, Keightley PD, Halligan DL ( 2007 ) . Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites . Journal of Molecular Evolution vol. 65 , ( 6 ) 627 - 639 .
Wang J, Keightley PD, Johnson T ( 2006 ) . MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution . BMC Bioinformatics vol. 7 ,