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Research

Publications: Prof Angray Kang

Tallantyre EC, Scurr MJ, Vickaryous N, Richards A, Anderson V, Baker D, Chance R, Evangelou N et al. ( 2022 ) . Response to COVID-19 booster vaccinations in seronegative people with multiple sclerosis . Multiple Sclerosis and Related Disorders vol. 64 ,
Baker D, MacDougall A, Kang AS, Schmierer K, Giovannoni G, Dobson R ( 2022 ) . Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals? . Clin Exp Immunol vol. 207 , ( 3 ) 263 - 271 .
Baker D, MacDougall A, Kang AS, Schmierer K, Giovannoni G, Dobson R ( 2022 ) . Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals? . Clinical and Experimental Immunology vol. 207 , ( 3 ) 263 - 271 .
Baker D ( 2021 ) . CD19 B cell repopulation after ocrelizumab, alemtuzumab and cladribine: Implications for SARS-CoV-2 vaccinations in multiple sclerosis . Multiple Sclerosis and Related Disorders
Dobson R, Baker D, Kang A, Schmierer K, Giovannoni G ( 2021 ) . COVID-19 vaccine response in people with multiple sclerosis . Annals of Neurology
Vickaryous N, Asardag AN, Chance R, Jones M, Bestwick J, Shah SN, George K, Schmierer K et al. ( 2021 ) . Seroconversion following vaccination against SARS-CoV-2 in people with MS: impact of disease modifying therapy . MULTIPLE SCLEROSIS JOURNAL vol. 27 , ( 2_SUPPL ) 775 - 776 .
Baker D, Asardag AN, Quinn OA, Efimov A, Kang AS ( 2021 ) . Anti-drug antibodies to antibody-based therapeutics in multiple sclerosis . Hum Antibodies
Patel V, Efimov A, Baker D, Kang AS ( 2021 ) . Immunogenicity of biologics used in the treatment of moderate to severe psoriasis . Human Antibodies vol. 29 , ( 3 ) 171 - 178 .
Bqain M, Efimov A, Baker D, Kang AS ( 2021 ) . Immunogenicity of biologics used in the treatment of inflammatory bowel disease: A review . Human Antibodies
Munger K, Kang A, Baker D, Goodman A, Samkoff L ( 2020 ) . Alemtuzumab depletion failure and neutralizing anti-drug antibodies: a case report and call for monitoring . MULTIPLE SCLEROSIS JOURNAL . vol. 26 , 258 - 258 .
Senusi A, Kang A, Buchanan JAG, Adesanya A, Aloraini G, Stanford M, Fortune F ( 2020 ) . New mouthwash: an efficacious intervention for oral ulceration associated with Behçet's disease . British Journal of Oral and Maxillofacial Surgery vol. 58 , ( 8 ) 1034 - 1039 .
Baker D, Roberts CAK, Pryce G, Kang AS, Marta M, Reyes S, Schmierer K, Giovannoni G et al. ( 2020 ) . COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases . Clinical and Experimental Immunology vol. 202 , ( 2 ) 149 - 161 .
Baker D, Amor S, Kang AS, Schmierer K, Giovannoni G ( 2020 ) . The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic . Multiple Sclerosis and Related Disorders vol. 43 ,
Li J, Wang J, Kang AS, Sacitharan PK ( 2020 ) . Mapping the T cell response to COVID-19 . Signal Transduction and Targeted Therapy vol. 5 , ( 1 )
Saxena G, Moore JM, Jones M, Pryce G, Ali L, Leisegang GR, Vijay V, Loveless S et al. ( 2020 ) . Detecting and predicting neutralization of alemtuzumab responses in MS . Neurology(R) neuroimmunology & neuroinflammation vol. 7 , ( 4 )
Houacine S, Kang A, Parkinson EK, Wan H, Fortune F ( 2020 ) . Induction of p53 in keratinocyte cultures treated with Behçet's patient sera . Journal of Oral Pathology and Medicine vol. 49 , ( 5 ) 435 - 442 .
Jiang Y, Yi C, Yi Y, Jin Q, Kang AS, Li J, Kumar Sacitharan P ( 2020 ) . Adiponectin exacerbates influenza infection in elderly individuals via IL-18 . Signal Transduct Target Ther vol. 5 , ( 1 )
Puentes F, Lombardi V, Lu C-H, Yildiz O, Kang A, Nissim A, Fratta P, Isaacs A et al. ( 2020 ) . Immune reactivity to neurofilaments and dipeptide repeats in ALS progression .
Ali L, SAXENA G, Jones M, Leisegang G, Gammon L, Gnanapavan S, Giovannoni G, Schmierer K et al. ( 2020 ) . A cell-based assay for the detection of neutralizing antibodies against alemtuzumab . BioTechniques: the journal of laboratory technology for bioresearch
Baker D, Ali L, SAXENA G, Pryce G, Jones M, Schmierer K, Giovannoni G, Gnanapavan S et al. ( 2020 ) . The irony of humanization: Alemtuzumab the first, but one of the most immunogenic, humanized monoclonal antibodies . Frontiers in Immunology vol. 11 , ( 124 )
Saxena GK, Theocharopoulos I, Aziz NT, Jones M, Gnanapavan S, Giovannoni G, Schmierer K, Garnett JA et al. ( 2020 ) . GloBody Technology: Detecting Anti-Drug Antibody against VH/VL domains . Scientific Reports vol. 10 , ( 1 ) Article 1860 ,
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R et al. ( 2019 ) . Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and Phospho-YAP in keratinocyte responses to mechanical forces . International Journal of Molecular Sciences vol. 20 , ( 24 )
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly A, Kang A, Soetaert J, Chance R et al. ( 2019 ) . The desmosomal cadherin Desmoglein-3 regulates YAP and phospho-YAP in keratinocyte responses to mechanical forces .
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J et al. ( 2019 ) . The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53 . Cell Death and Disease vol. 10 , ( 10 )
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teh T, Uttagomol J, Kang A et al. ( 2018 ) . The <i>Pemphigus Vulgaris</i> antigen desmoglein-3 suppresses p53 function via the YAP-Hippo pathway .
Dubuisson N, Baker D, Kang AS, Pryce G, Marta M, Visser LH, Hofmann WE, Gnanapavan S et al. ( 2018 ) . Alemtuzumab depletion failure can occur in multiple sclerosis . Immunology vol. 154 , ( 2 ) 253 - 260 .
Baker D, Kang AS, Gnanapavan S, Giovannoni G, Schmierer K ( 2017 ) . A central role of B cells in MS control and causing autoimmunity after alemtuzumab . MULTIPLE SCLEROSIS JOURNAL . vol. 23 , 336 - 336 .
Sylejmani G, Gupta A, Cheng Q, Kang A, Durvasula R, Hurwitz I ( 2014 ) . DEVELOPMENT OF RECOMBINANT ANTIBODIES TO COMBAT CLOSTRIDIUM DIFFICILE INFECTION . JOURNAL OF INVESTIGATIVE MEDICINE . vol. 62 , 229 - 229 .
Tang J, Wang L, Markiv A, Jeffs SA, Dreja H, McKnight A, He M, Kang AS ( 2012 ) . Accessing of recombinant human monoclonal antibodies from patient libraries by eukaryotic ribosome display . Human Antibodies vol. 21 , ( 1-2 ) 1 - 11 .
Ujor VC, Peiris DG, Monti M, Kang AS, Clements MO, Hedger JN ( 2012 ) . Quantitative proteomic analysis of the response of the wood-rot fungus, Schizophyllum commune, to the biocontrol fungus, Trichoderma viride . Lett Appl Microbiol vol. 54 , ( 4 ) 336 - 343 .
Azizi A, Arora A, Markiv A, Lampe DJ, Miller TA, Kang AS ( 2012 ) . Ribosome Display of Combinatorial Antibody Libraries Derived from Mice Immunized with Heat-Killed Xylella fastidiosa and the Selection of MopB-Specific Single-Chain Antibodies . APPLIED AND ENVIRONMENTAL MICROBIOLOGY vol. 78 , ( 8 ) 2638 - 2647 .
Hurwitz I, Fieck A, Klein N, Jose C, Kang A, Durvasula R ( 2012 ) . A paratransgenic strategy for the control of chagas disease . Psyche (London)
Markiv A, Beatson R, Burchell J, Durvasula RV, Kang AS ( 2011 ) . Expression of recombinant multi-coloured fluorescent antibodies in gor -/trxB- E. coli cytoplasm . BMC Biotechnol vol. 11 ,
Jacobs-Lorena M, Wang S, Lampe D, Fang W, Vega-Rodriguez J, Ghosh A, Kang A, Leger RS ( 2011 ) . Fighting malaria with engineered fungi and bacteria . TROPICAL MEDICINE & INTERNATIONAL HEALTH . vol. 16 , 9 - + .
Tsimon M, Kang A, Markiv A, Kousparou C, Epenetos A ( 2011 ) . Abstract 4441: Intracellular delivery of therapeutic siRNA via an antennapedia-RNA-binding domain fusion peptide . Cancer Research vol. 71 , ( 8_Supplement ) 4441 - 4441 .
Fang W, Vega-Rodríguez J, Ghosh AK, Jacobs-Lorena M, Kang A, St Leger RJ ( 2011 ) . Development of transgenic fungi that kill human malaria parasites in mosquitoes . Science vol. 331 , ( 6020 ) 1074 - 1077 .
Markiv A, Anani B, Durvasula RV, Kang AS ( 2011 ) . Module based antibody engineering: a novel synthetic REDantibody . J Immunol Methods vol. 364 , ( 1-2 ) 40 - 49 .
Hurwitz I, Fieck A, Read A, Hillesland H, Klein N, Kang A, Durvasula R ( 2011 ) . Paratransgenic control of vector borne diseases . Int J Biol Sci vol. 7 , ( 9 ) 1334 - 1344 .
Damiani C, Ricci I, Crotti E, Rossi P, Rizzi A, Scuppa P, Capone A, Ulissi U et al. ( 2010 ) . Mosquito-bacteria symbiosis: the case of Anopheles gambiae and Asaia . Microb Ecol vol. 60 , ( 3 ) 644 - 654 .
Fieck A, Hurwitz I, Kang AS, Durvasula R ( 2010 ) . Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts . Exp Parasitol vol. 125 , ( 4 ) 342 - 347 .
Nguyen TV, Sacci JB, de la Vega P, John CC, James AA, Kang AS ( 2009 ) . Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals . Malar J vol. 8 ,
Peterson JW, Comer JE, Noffsinger DM, Wenglikowski A, Walberg KG, Chatuev BM, Chopra AK, Stanberry LR et al. ( 2006 ) . Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax . Infection and Immunity vol. 74 , ( 2 ) 1016 - 1024 .
Stratmann T, Kang AS ( 2005 ) . Cognate peptide-receptor ligand mapping by directed phage display . Proteome Science vol. 3 ,
Cote CK, Rossi CA, Kang AS, Morrow PR, Lee JS, Welkos SL ( 2005 ) . The detection of protective antigen (PA) associated with spores of Bacillus anthracis and the effects of anti-PA antibodies on spore germination and macrophage interactions . Microbial Pathogenesis vol. 38 , ( 5-6 ) 209 - 225 .
Cote CK, Rossi CA, Kang AS, Morrow PR, Lee JS, Welkos SL ( 2005 ) . The Detection of Protective Antigen (PA) Associated with Spores of Bacillus Anthracis and the Effects of Anti-PA Antibodies on Spore Germination and Macrophage Interactions .
Chappel JA, Rogers WO, Hoffman SL, Kang AS ( 2004 ) . Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor . Malaria Journal vol. 3 ,
Sawada-Hirai R, Jiang I, Wang F, Sun SM, Nedellec R, Ruther P, Alvarez A, Millis D et al. ( 2004 ) . Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed . Journal of Immune Based Therapies and Vaccines vol. 2 ,
Wang F, Ruther P, Jiang I, Sawada-Hirai R, Sun SM, Nedellec R, Morrow PR, Kang AS ( 2004 ) . Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly . Human Antibodies vol. 13 , ( 4 ) 105 - 110 .
Chappel JA, Hollingdale MR, Kang AS ( 2004 ) . IgG<inf>4</inf> Pf NPNA-1 a human anti-Plasmodium falciparum sporozoite monoclonal antibody cloned from a protected individual inhibits parasite invasion of hepatocytes . Human Antibodies vol. 13 , ( 3 ) 91 - 96 .
Nguyen TV, Fujioka H, Kang AS, Rogers WO, Fidock DA, James AA ( 2001 ) . Stage-dependent Localization of a Novel Gene Product of the Malaria Parasite, Plasmodium falciparum . Journal of Biological Chemistry vol. 276 , ( 28 ) 26724 - 26731 .
Stratmann T, Apostolopoulos V, Mallet-Designe V, Corper AL, Scott CA, Wilson IA, Kang AS, Teyton L ( 2000 ) . The I-A(g7) MHC class II molecule linked to murine diabetes is a promiscuous peptide binder . Journal of Immunology vol. 165 , ( 6 ) 3214 - 3225 .
Corper AL, Stratmann T, Apostolopoulos V, Scott CA, Garcia KC, Kang AS, Wilson IA, Teyton L ( 2000 ) . A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes . Science vol. 288 , ( 5465 ) 505 - 511 .
Lode HN, Dreier T, Xiang R, Varki NM, Kang AS, Reisfeld RA ( 2000 ) . Erratum: Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma (Proceedings of the National Academy of Sciences of the United States of America (March 3, 1998) 95:5 (2475-2480)) . Proceedings of the National Academy of Sciences of the United States of America vol. 97 , ( 7 )
Durvasula RV, Gumbs A, Panackal A, Kruglov O, Taneja J, Kang AS, Cordon-Rosales C, Richards FF et al. ( 1999 ) . Expression of a functional antibody fragment in the gut of Rhodnius prolixus via transgenic bacterial symbiont Rhodococcus rhodnii . Medical and Veterinary Entomology vol. 13 , ( 2 ) 115 - 119 .
Chappel JA, He M, Kang AS ( 1998 ) . Modulation of antibody display on M13 filamentous phage . Journal of Immunological Methods vol. 221 , ( 1-2 ) 25 - 34 .
Lode HN, Dreier T, Xiang R, Varki NM, Kang AS, Reisfeld RA ( 1998 ) . Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma . Proceedings of the National Academy of Sciences of the United States of America vol. 95 , ( 5 ) 2475 - 2480 .
Dreier T, Lode HN, Xiang R, Dolman CS, Reisfeld RA, Kang AS ( 1998 ) . Recombinant immunocytokines targeting the mouse transferrin receptor: Construction and biological activities . Bioconjugate Chemistry vol. 9 , ( 4 ) 482 - 489 .
Stratmann T, Schmid SR, Harper JF, Kang AS ( 1997 ) . Bacterial expression and purification of recombinant Plasmodium yoelii circumsporozoite protein . Protein Expression and Purification vol. 11 , ( 1 ) 72 - 78 .
Mason P, Berinstein A, Baxt B, Parsells R, Kang A, Rieder E ( 1996 ) . Cloning and expression of a single-chain antibody fragment specific for foot-and-mouth disease virus . Virology vol. 224 , ( 2 ) 548 - 554 .
Rieder E, Berinstein A, Baxt B, Kang A, Mason PW ( 1996 ) . Propagation of an attenuated virus by design: Engineering a novel receptor for a noninfectious foot-and-mouth disease virus . Proceedings of the National Academy of Sciences of the United States of America vol. 93 , ( 19 ) 10428 - 10433 .
He M, Hamon M, Liu H, Kang A, Taussig MJ ( 1995 ) . Functional expression of a single-chain anti-progesterone antibody fragment in the cytoplasm of a mutant Escherichia coil . Nucleic Acids Research vol. 23 , ( 19 ) 4009 - 4010 .
He M, Kang AS, Hamon M, Humphreys AS, Gani M, Taussig MJ ( 1995 ) . Characterization of a progesterone-binding, three-domain antibody fragment (V(H)/K) expressed in Escherichia coli . Immunology vol. 84 , ( 4 ) 662 - 668 .
Stura EA, Kang AS, Stefanko RS, Calvo JC, Kaslow DC, Satterthwait AC ( 1994 ) . Crystallization, sequence and preliminary crystallographic data for transmission-blocking anti-malaria Fab 4B7 with cyclic peptides from the Pfs25 protein of P. falciparum . Acta Crystallogr D Biol Crystallogr vol. 50 , ( Pt 4 ) 535 - 542 .
Lerner RA, Kang AS, Bain JD, Burton DR, Barbas CF ( 1992 ) . Antibodies without immunization . Science vol. 258 , ( 5086 ) 1313 - 1314 .
Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA ( 1992 ) . Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. 1989 . Biotechnology (Reading, Mass.) vol. 24 , 517 - 523 .
Gram H, Marconi LA, Barbas CF, Collet TA, Lerner RA, Kang AS ( 1992 ) . In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library . Proceedings of the National Academy of Sciences of the United States of America vol. 89 , ( 8 ) 3576 - 3580 .
Kang AS, Barbas CF, Janda KD, Benkovic SJ, Lerner RA ( 1991 ) . Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces . Proceedings of the National Academy of Sciences of the United States of America vol. 88 , ( 10 ) 4363 - 4366 .
Kang AS, Jones TM, Burton DR ( 1991 ) . Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries . Proceedings of the National Academy of Sciences of the United States of America vol. 88 , ( 24 ) 11120 - 11123 .
Barbas CF, Kang AS, Lerner RA, Benkovic SJ ( 1991 ) . Assembly of combinatorial antibody libraries on phage surfaces: The gene III site . Proceedings of the National Academy of Sciences of the United States of America vol. 88 , ( 18 ) 7978 - 7982 .
Kang AS, Burton DR, Lerner RA ( 1991 ) . Combinatorial immunoglobulin libraries in phage λ . Methods vol. 2 , ( 2 ) 111 - 118 .
Lerner RA, Barbas CF, Kang AS, Burton DR ( 1991 ) . On the use of combinatorial antibody libraries to clone the 'fossil record' of an individual's immune response . Proceedings of the National Academy of Sciences of the United States of America vol. 88 , ( 21 ) 9705 - 9706 .
Kang AS, Kingsbury GA, Blackburn GM, Burton DR ( 1990 ) . Catalytic antibodies. Designer enzymes . Chemistry in Britain vol. 26 , ( 2 ) 128 - 132 .
Field H, Yeung HLH, Rees AR, Bagshawe KD, Kang AS, Burton DR, Blackburn GM, Hill CR et al. ( 1990 ) . New applications for antibodies . Analytical Proceedings . vol. 27 , 2 - 15 .
Au DMY, Kang AS, Murphy DJ ( 1989 ) . Low-resolution epitope characterisation in a family of seed apolipoproteins using polyclonal antibodies . Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism vol. 1005 , ( 1 ) 97 - 102 .
Au DMY, Kang AS, Murphy DJ ( 1989 ) . An immunologically related family of apolipoproteins associated with triacylglycerol storage in the Cruciferae . Archives of Biochemistry and Biophysics vol. 273 , ( 2 ) 516 - 526 .
Blackburn GM, Kang AS, Kingsbury GA, Burton DR ( 1989 ) . Catalytic antibodies . Biochemical Journal vol. 262 , ( 2 ) 381 - 390 .
Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA ( 1989 ) . Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda . Science vol. 246 , ( 4935 ) 1275 - 1281 .
Murphy DJ, Cummins I, Kang AS ( 1989 ) . Immunocytochemical and biochemical studies of the mobilisation of storage oil‐bodies and proteins in germinating cotyledons of oilseed rape, Brassica napus . Journal of the Science of Food and Agriculture vol. 48 , ( 2 ) 209 - 223 .
Murphy DJ, Cummins I, Kang AS ( 1989 ) . Immunological investigation of lipases in germinating oilseed rape, Brassica napus . Journal of the Science of Food and Agriculture vol. 47 , ( 1 ) 21 - 31 .
Murphy DJ, Cummins I, Kang AS ( 1989 ) . Synthesis of the major oil-body membrane protein in developing rapeseed (Brassica napus) embryos. Integration with storage-lipid and storage-protein synthesis and implications for the mechanism of oil-body formation . The Biochemical journal vol. 258 , ( 1 ) 285 - 293 .
Crop RRD, Evans IM, Yarwood JN, Harris N, Gatehouse JA, Shirsat AH, Kang A, Ellis JR et al. ( 1988 ) . Expression of Pea Legumin Sequences in Pea, Nicotiana and Yeast . Journal of Plant Physiology vol. 183 , ( 2-3 ) 183 - 197 .
Morgan MRA, Kang AS, Chan HW ( 1986 ) . Aflatoxin determination in peanut butter by enzyme‐linked immunosorbent assay . Journal of the Science of Food and Agriculture vol. 37 , ( 9 ) 908 - 914 .
Morgan MRA, Kang AS, Chan HW ( 1986 ) . Production of antisera against sterigmatocystin hemiacetal and its potential for use in an enzyme‐linked immunosorbent assay for sterigmatocystin in barley . Journal of the Science of Food and Agriculture vol. 37 , ( 9 ) 873 - 880 .
Chant SR, Gbaja IS, Kang AS ( 1984 ) . Effect of nutrition on the interaction of Fusarium oxysporum and Sunn-hemp mosaic virus in cowpea seedlings . Tropical agriculture. vol. 61 , ( 2 ) 87 - 91 .