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  1. Queen Mary University of London
  2. Research
  3. Publications

Publications: Dr Silvana Debernardi

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Tajbakhsh J, Debernardi S, Blyuss O, Bai J, Weng R, Lo S, Pandol SJ, Crnogorac-Jurcevic T et al. ( 2024 ) . A CLIA/CAP Compliant Noninvasive Laboratory Developed Test for Early Detection of Pancreatic Ductal Adenocarcinoma . Journal of Molecular Diagnostics
Ali N, Debernardi S, Kurotova E, Tajbakhsh J, Gupta NK, Pandol SJ, Wilson P, Pereira SP et al. ( 2024 ) . Evaluation of urinary C-reactive protein as an early detection biomarker for pancreatic ductal adenocarcinoma . Frontiers in Oncology vol. 14 ,
Schilling K, Chen H, Glabonjat RA, Debernardi S, Blyuss O, Navas-Acien A, Halliday AN, Crnogorac-Jurcevic T ( 2024 ) . Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states . Frontiers in Endocrinology vol. 15 ,
Debernardi S, Liszka L, Ntala C, Steiger K, Esposito I, Carlotti E, Baker A, McDonald S et al. ( 2024 ) . Molecular characteristics of early‐onset pancreatic ductal adenocarcinoma . Molecular Oncology vol. 18 , ( 3 ) 677 - 690 .
Debernardi S, Blyuss O, Rycyk D, Srivastava K, Jeon CY, Cai H, Cai Q, Shu X et al. ( 2022 ) . Urine biomarkers enable pancreatic cancer detection up to 2 years before diagnosis . International Journal of Cancer vol. 152 , ( 4 ) 769 - 780 .
Debernardi S, O’Brien H, Algahmdi AS, Malats N, Stewart GD, Plješa-Ercegovac M, Costello E, Greenhalf W et al. ( 2020 ) . A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case–control study . PLOS Medicine vol. 17 , ( 12 )
Crnogorac-Jurcevic T, Debernardi S, Jach D, Brezgyte G, Ney A, Pereira SP, Greenhalf W, Wilson P et al. ( 2020 ) . EARLY DETECTION OF PANCREATIC ADENOCARCINOMA IN ‘AT-RISK’ POPULATIONS USING A BIOMARKER PANEL IN URINE (UROPANC) . Pancreatology . vol. 20 ,
Debernardi S, Jach D, Brezgyte G, Blyuss O, Crnogorac-Jurcevic T ( 2020 ) . A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer . Pancreatology . vol. 20 ,
Daulton E, Wicaksono AN, Tiele A, Kocher HM, Debernardi S, Crnogorac-Jurcevic T, Covington JA ( 2020 ) . Volatile organic compounds (VOCs) for the non-invasive detection of pancreatic cancer from urine . Talanta vol. 221 ,
Ntala C, Debernardi S, Feakins RM, Crnogorac-Jurcevic T ( 2018 ) . Demographic, clinical, and pathological features of early onset pancreatic cancer patients . BMC Gastroenterology vol. 18 , ( 1 )
Debernardi S, Massat NJ, Radon TP, Sangaralingam A, Banissi A, Ennis DP, Dowe T, Chelala C et al. ( 2015 ) . Noninvasive urinary miRNA biomarkers for early detection of pancreatic adenocarcinoma . American Journal of Cancer Research vol. 5 , ( 11 ) 3455 - 3466 .
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. ( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia . Blood vol. 123 , ( 13 ) 2066 - 2074 .
Manodoro F, Marzec J, Chaplin T, Miraki-Moud F, Moravcsik E, Jovanovic JV, Wang J, Iqbal S et al. ( 2014 ) . Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukaemia . BRITISH JOURNAL OF HAEMATOLOGY . vol. 165 , 16 - 16 .
Manodoro F, Marzec J, Wang J, Chaplin T, Jovanovic JV, Eva M, Sameena I, Grimwade D et al. ( 2013 ) . Loss of Imprinting at the 14q32 Domain Leads to MicroRNA Overexpression in Acute Promyelocytic Leukemia . Blood . vol. 122 ,
Manodoro F, Marzec J, Wang J, Chaplin T, Young B, Debernardi S ( 2012 ) . DEEP SEQUENCING REVEALS ALLELE-SPECIFIC HYPERMETHYLATION AT 14Q32 IMPRINTED DOMAIN IN ACUTE PROMYELOCITIC LEUKAEMIA (APML) . HAEMATOLOGICA . vol. 97 , 14 - 14 .
Saied MH, Marzec J, Khalid S, Smith P, Down TA, Rakyan VK, Molloy G, Raghavan M et al. ( 2012 ) . Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats . PLoS One vol. 7 , ( 3 )
Szlosarek PW, Luong F, Clear A, Taussig D, Joel S, Calaminici M, Debernardi S, Fitzgibbon J et al. ( 2011 ) . Abstract 4067: Pegylated arginine deiminase (ADI-PEG20) as a potential novel therapy for argininosuccinate synthetase-deficient acute myeloid leukemia . Cancer Research . vol. 71 , 4067 - 4067 .
Szlosarek PW, Luong F, Clear A, Taussig D, Joel S, Calaminici M, Debernardi S, Fitzgibbon J et al. ( 2011 ) . Pegylated arginine deiminase (ADI-PEG20) as a potential novel therapy for argininosuccinate synthetase-deficient acute myeloid leukemia . CANCER RESEARCH . vol. 71 ,
Debernardi S, Marzec J, Manodoro F, Dobson R, Mein C, Curtotti A, Mitchell M, Young BD ( 2010 ) . Discovery and Quantification of Small RNA Molecules In Acute Myeloid Leukaemia Using Solexa High Throughput Clonal Sequencing . BLOOD . vol. 116 , 369 - 369 .
Debernardi S, Marzec J, Manodoro F, Dobson R, Mein C, Curtotti A, Mitchell M, Young BD ( 2010 ) . Discovery and Quantification of Small RNA Molecules In Acute Myeloid Leukaemia Using Solexa High-Throughput Clonal Sequencing . BLOOD . vol. 116 , 369 - 369 .
Saied M, Khaled S, Down T, Marzec J, Smith P, Debernardi S, Young BD ( 2010 ) . Genome Wide Study of DNA Methylation In AML . BLOOD . vol. 116 , 1489 - 1489 .
Lillington DM, Debernardi S, Young BD ( 2010 ) . Molecular Cytogenetics and Array‐Based Genomic Analysis . Molecular Hematology , Wiley
Debernardi S, Dixon-McIver A ( 2010 ) . MicroRNA detection in bone marrow cells by LNA-FISH . vol. 667 ,
Debernardi S, De Bellis G, Mosca A, Paleari R, Luzzana M ( 2009 ) . Characterization of Hb Camperdown [β104(G6)ARG → SER] by Capillary Electrophoresis and Automated Solid Phase DNA Sequencing . Hemoglobin vol. 20 , ( 2 ) 155 - 160 .
Mosca A, Paleari R, Rubino FM, Zecca L, De Bellis G, Debernardi S, Baudo F, Cappellini D et al. ( 2009 ) . HB Abruzzo [β143(H21)HIS→ARG] Identified by Mass Spectrometry and DNA Analysis . Hemoglobin vol. 17 , ( 3 ) 261 - 268 .
Paleari R, Mosca A, Maccaronio A, De Bellis G, Debernardi S, Lang F, Luzi L ( 2009 ) . Hb Agenogi [β90(f6)GLU->LYS] Identified by Dna Analysis . Hemoglobin vol. 18 , ( 4-5 ) 347 - 351 .
di Montemuros FM, Cappellini MD, Dotti C, Tavazzi D, De Bellis G, Debernardi S, Fiorelli G ( 2008 ) . Molecular characterisation of an Italian G6PD variant responsible for chronic non‐spherocytic haemolytic anaemia . Clinical Genetics vol. 46 , ( 5 ) 357 - 359 .
Dixon-McIver A, East P, Mein CA, Cazier J-B, Molloy G, Chaplin T, Andrew Lister T, Young BD et al. ( 2008 ) . Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia . PLoS One vol. 3 , ( 5 )
Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, Chaplin T, Lister TA, Young B et al. ( 2007 ) . Association of MicroRNA expression profiles with karyotype in acute myeloid leukaemias revealed by real-time PCR and in situ hybridisation . BLOOD . vol. 110 , 39A - 39A .
Lillington DM, Debernardi S, Young BD ( 2007 ) . Molecular Cytogenetics . Molecular Hematology , Wiley
Debernardi S, Skoulakis S, Molloy G, Chaplin T, Dixon-McIver A, Young BD ( 2007 ) . MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis . Leukemia vol. 21 , ( 5 ) 912 - 916 .
Dunne J, Cullmann C, Ritter M, Soria NM, Drescher B, Debernardi S, Skoulakis S, Hartmann O et al. ( 2006 ) . siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts . Oncogene vol. 25 , ( 45 ) 6067 - 6078 .
Young BD, Debernardi S, Lillington DM, Skoulakis S, Chaplin T, Foot NJ, Raghavan M ( 2006 ) . A role for mitotic recombination in leukemogenesis . Editors: Weber, G, Weber, CEF, Cocco, L , vol. 46 ,
Fitzgibbon J, Smith LL, Raghavan M, Smith ML, Debernardi S, Skoulakis S, Lillington D, Lister TA et al. ( 2005 ) . Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias . CANCER RES vol. 65 , ( 20 ) 9152 - 9154 .
Lister TA, FITZGIBBON J, Young BD, Skoulakis S, Smith ML, Lillington D, Smith LL, Debernardi S et al. ( 2005 ) . Association between Acquired Uniparental Disomy and Homozygous Gene Mutation in Acute Myeloid Leukemias . vol. 65 , is. 20 , pp. 9152 - 9154 .
Raghavan M, Lillington D, Skoulakis S, Debernardi S, Chaplin T, Foot NJ, Lister TA, Young BD ( 2005 ) . A genome wide array based single nucleotide polymorphism (SNP) analysis shows frequent uniparental disomy (UPD) due to somatic recombination in acute myeloid leukaemia (AML) . BRITISH JOURNAL OF HAEMATOLOGY . vol. 129 , 40 - 40 .
Lister TA, YOUNG B, Debernardi S, Chaplin T, Foot NJ, Raghavan M, Lillington DM, Skoulakis S ( 2005 ) . Genome-Wide Single Nucleotide Polymorphism Analysis Reveals Frequent Partial Uniparental Disomy Due to Somatic Recombination in Acute Myeloid Leukemias . vol. 65 , is. 2 , pp. 375 - 378 .
Last K, Debarnardi S, Lister TA ( 2005 ) . Molecular diagnosis of lymphoma: outcome prediction by gene expression profiling in diffuse large B-cell lymphoma . vol. 115 ,
Woodfine K, Beare DM, Ichimura K, Debernardi S, Mungall AJ, Fiegler H, Collins VP, Carter NP et al. ( 2005 ) . Replication timing of human chromosome 6 . CELL CYCLE vol. 4 , ( 1 ) 172 - 176 .
Raghavan M, Lillington D, Skoulakis S, Debernardi S, Chaplin T, Foot NJ, Lister TA, Young BD ( 2004 ) . Genome Wide SNP Analysis Reveals Frequent Uniparental Disomy (UPD) Due to Somatic Recombination in Acute Myeloid Leukemias . Blood vol. 104 , ( 11 )
Raghavan M, Lillington D, Skoulakis S, Debernardi S, Chaplin T, Foot NJ, Lister TA, Young BD ( 2004 ) . Genome wide SNP analysis reveals frequent uniparental disomy (UPD) due to somatic recombination in acute myeloid leukemias . BLOOD . vol. 104 , 43A - 43A .
Debernardi S, Lillington D, Young BD ( 2004 ) . Understanding cancer at the chromosome level: 40 years of progress . vol. 40 ,
Woodfine K, Fiegler H, Beare DM, Collins JE, McCann OT, Young BD, Debernardi S, Mott R et al. ( 2004 ) . Replication timing of the human genome . HUM MOL GENET vol. 13 , ( 2 ) 191 - 202 .
Woodfine K, Fiegler H, Beare DM, Collins JE, McCann OT, Young BD, Debernardi S, Mott R et al. ( 2004 ) . Replication timing of the human genome . Human Molecular Genetics vol. 13 , ( 5 ) 575 - 575 .
Debernardi S, Smith M, Lillington DM, Chaplin T, Rohatiner A, Lister A, Young BD ( 2003 ) . Expression profiling and mutational analysis identifies a new subgroup of normal karyotype AML . BLOOD . vol. 102 , 364A - 364A .
Debernardi S, Van Delft F, Davies A, Lillington D, Smith M, Lister TA, Saha V, Young BD et al. ( 2003 ) . The Wiskott-Aldrich-Syndrome family member 1 (WASF1) gene on 6q21 is down-regulated in specific AML cytogenetic subtypes . BLOOD . vol. 102 , 582A - 582A .
Chambers AE, Banerjee S, Chaplin T, Dunne J, Debernardi S, Joel SP, Young BD ( 2003 ) . Histone acetylation-mediated regulation of genes in leukaemic cells (vol 39, pg 1165, 2003) . EUR J CANCER . vol. 39 , 2411 - 2411 .
Lillington D, Debernardi S, Sanmugathasan A, Carr P, Onadim Z, Kingston J, Carter N, Young B ( 2003 ) . The analysis of malignant disease using microarrays . JOURNAL OF MEDICAL GENETICS . vol. 40 , S29 - S29 .
Debernardi S, Lillington DM, Chaplin T, Tomlinson S, Amess J, Rohatiner A, Lister TA, Young BD ( 2003 ) . Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events . Genes Chromosomes Cancer vol. 37 , ( 2 ) 149 - 158 .
Chambers AE, Banerjee S, Chaplin T, Dunne J, Debernardi S, Joel SP, Young BD ( 2003 ) . Histone acetylation-mediated regulation of genes in leukaemic cells . EUR J CANCER vol. 39 , ( 8 ) 1165 - 1175 .
Lillington DM, Young BD, Chaplin T, Tomlinson S, Amess JA, Rohatiner AZ, Lister TA, Debernardi S ( 2002 ) . A distinct pattern of gene expression is highly correlated with the major cytogenetic subgroups in AML . vol. 39 , pp. S17 - S17 .
JONES LK, Young BD, de Bruijn DR, Linder B, Chaplin T, Bassini A, Debernardi S, Meese E ( 2002 ) . The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SW1/SNF complex . Blood. vol. 99 , ( 1 ) 275 - 281 .
Jones LK, YOUNG B, Chaplin T, Debernardi S, Bassini A, Meese E, Linder B, de Bruijn DR ( 2002 ) . The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex . Blood vol. 99 , ( 1 ) 275 - 281 .
Jones LK, Chaplin T, Shankar A, Neat M, Patel N, Samuel DP, Hill AS, Debernardi S et al. ( 2001 ) . Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia . LEUKEMIA vol. 15 , ( 6 ) 910 - 914 .
de Bruijn DRH, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, van Kessel AG ( 2001 ) . The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 . ONCOGENE vol. 20 , ( 25 ) 3281 - 3289 .
Chaplin T, Jones L, Debernardi S, Hill AS, Lillington DM, Young BD ( 2001 ) . Molecular analysis of the genomic inversion and insertion of AF10 into MLL suggests a single-step event . Genes Chromosomes Cancer vol. 30 , ( 2 ) 175 - 180 .
Panigone S, Debernardi S, Taya Y, Fontanella E, Airoldi R, Delia D ( 2000 ) . pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide . Oncogene vol. 19 , ( 35 ) 4035 - 4041 .
Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V ( 2000 ) . Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation . J MOL BIOL vol. 299 , ( 2 ) 369 - 378 .
Debernardi S, Jones LK, Chaplin T, Bassini A, Britta L, Meese E, DeBruin D, Young BD ( 2000 ) . AF10 interacts with GAS41 and INI1, a component of the human SWI/SNF complex . BLOOD vol. 96 , ( 11 ) 88A - 89A .
Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D ( 1997 ) . Identification of a Novel Human Kinesin-Related Gene (HK2) by the cDNA Differential Display Technique . Genomics vol. 42 , ( 1 ) 67 - 73 .
Cappellini MD, di Montemuros FM, De Bellis G, Debernardi S, Dotti C, Fiorelli G ( 1996 ) . Multiple G6PD Mutations Are Associated With a Clinical and Biochemical Phenotype Similar to That of G6PD Mediterranean . Blood vol. 87 , ( 9 ) 3953 - 3958 .
Debernardi S, Luzzana M, De Bellis G ( 1996 ) . Solid phase purification and SSCP analysis of amplified genomic DNA by capillary electrophoresis . Frontiers in Bioscience-Landmark vol. 1 , ( 3 ) c1 - c3 .
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