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Research

Publications: Dr Elisa Corsiero

Prediletto E, Cubuk C, Pontarini E, Rivellese F, Nerviani A, Lucchesi D, Caliste M, Corsiero E et al. ( 2022 ) . POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 296.1 - 29296 .
Corsiero E, Caliste M, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2022 ) . POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 456.1 - 45456 .
Caliste M, Prediletto E, Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2022 ) . POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS . Annals of the Rheumatic Diseases vol. 81 , ( Suppl 1 ) 474.2 - 47475 .
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2022 ) . Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression . Cell Reports vol. 39 , ( 5 )
Vomero M, Caliste M, Barbati C, Speziali M, Celia AI, Ucci F, Ciancarella C, Putro E et al. ( 2022 ) . Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients . Frontiers in Pharmacology vol. 13 ,
Colombo F, Corsiero E, Lewis MJ, Pitzalis C ( 2021 ) . Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution . Scientific Reports vol. 11 , ( 1 )
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S et al. ( 2021 ) . Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression .
Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E et al. ( 2020 ) . Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma . Annals of the Rheumatic Diseases vol. 79 , ( 12 ) 1588 - 1599 .
Meednu N, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, Bombardieri M, DiCarlo E, Orange D et al. ( 2020 ) . Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling . ARTHRITIS & RHEUMATOLOGY . vol. 72 ,
Corsiero E, Carlotti E, Jagemann L, Perretti M, Pitzalis C, Bombardieri M ( 2020 ) . H and L chain affinity maturation and/or Fab N-glycosylation influence immunoreactivity toward neutrophil extracellular trap antigens in rheumatoid arthritis synovial b cell clones . Journal of Immunology vol. 204 , ( 9 ) 2374 - 2379 .
Pontarini E, Brown WM, Croia C, Lucchesi D, Rivellese F, Fossati-Jimack L, Ruscitti P, Prediletto E et al. ( 2019 ) . OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA . Conference: Oral Presentations221.1 - 22221 .
PITZALIS C, CORSIERO E, DELVECCHIO F, BOMBARDIERI M ( 2019 ) . B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis . Current Opinion in Immunology vol. 57 , 46 - 52 .
Corsiero E, Jagemann L, Bombardieri M, Pitzalis C ( 2018 ) . Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients . Methods Mol Biol vol. 1845 , 159 - 187 .
PITZALIS C, CORSIERO E, JAGEMANN L, PERRETTI M, BOMBARDIERI M ( 2018 ) . Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints . Journal of Immunology
Corsiero E, Jagemann L, Pontarini E, Fossati-Jimack L, Pitzalis C, Bombardieri M ( 2018 ) . Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma . CLINICAL AND EXPERIMENTAL RHEUMATOLOGY . vol. 36 , S249 - S249 .
Corsiero E, Jagemann L, Pitzalis C, Bombardieri M ( 2017 ) . Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Pontarini E, Brown WM, Croia C, Corsiero E, Lucchesi D, Astorri E, Sutcliffe N, Tappuni A et al. ( 2017 ) . T Follicular- Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren's Syndrome Patients . ARTHRITIS & RHEUMATOLOGY . vol. 69 ,
Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . Conference: Oral Presentations vol. 76 ,
Corsiero E, Jagemann L, Prediletto E, Pitzalis C, Bombardieri M ( 2017 ) . 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin . Annals of the Rheumatic Diseases . Conference: Autoimmune inflammation vol. 76 ,
Corsiero E, Pratesi F, Prediletto E, Bombardieri M, Migliorini P ( 2016 ) . NETosis as Source of Autoantigens in Rheumatoid Arthritis . Front Immunol vol. 7 , 485 - 485 .
Corsiero E, Nerviani A, Bombardieri M, Pitzalis C ( 2016 ) . Ectopic Lymphoid Structures: Powerhouse of Autoimmunity . Front Immunol vol. 7 , Article 00430 , 430 - 430 .
Corsiero E, Carlotti E, Prediletto E, Jagemann L, Pitzalis C, Bombardieri M ( 2016 ) . A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies . Annals of the Rheumatic Diseases . vol. 75 ,
Corsiero E, Bombardieri M, Carlotti E, Pratesi F, Robinson W, Migliorini P, Pitzalis C ( 2015 ) . Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs . Annals of the Rheumatic Diseases1866 - 1875 .
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al. ( 2015 ) . Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis . Science Translational Medicine vol. 7 , ( 315 )
Corsiero E, Carlotti E, Pitzalis C, Bombardieri M ( 2015 ) . FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies . Annals of the Rheumatic Diseases . vol. 74 ,
Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M, Reddy J ( 2014 ) . Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's Syndrome . PLoS ONE vol. 9 , ( 12 )
Corsiero E, Pitzalis C, Bombardieri M ( 2014 ) . Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis . Drug Discovery Today vol. 19 , ( 8 ) 1161 - 1165 .
Corsiero E, Carlotti E, Pratesi F, Wardemann H, Robinson W, Migliorini P, Pitzalis C, Bombardieri M ( 2014 ) . OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets . Annals of the Rheumatic Diseases . vol. 73 ,
Corsiero E, Carlotti E, Wardemann H, Robinson W, Migliorini P, Pratesi F, Pitzalis C, Bombardieri M ( 2014 ) . A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs . Annals of the Rheumatic Diseases . vol. 73 ,
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome . Annals of the Rheumatic Diseases vol. 72 , ( Suppl 3 )
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome . Annals of the Rheumatic Diseases vol. 71 , ( Suppl 3 )
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME . RHEUMATOLOGY . vol. 52 , 159 - 159 .
Corsiero E, Sutcliffe N, Wardemann H, Pitzalis C, Bombardieri M ( 2013 ) . A5.2 Accumulation of Circulating Autoreactive Naïve B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjögren’s Syndrome . Annals of the Rheumatic Diseases . vol. 72 ,
Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C ( 2012 ) . Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases . Immunology Letters vol. 145 , ( 1-2 ) 62 - 67 .
Bombardieri M, Astorri E, Corsiero E, Gabba S, Barone F, Proctor G, Pitzalis C ( 2010 ) . Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice . Annals of the Rheumatic Diseases . vol. 69 ,